CR2Cancer

Summary
Symbol	CBX8
Name	chromobox 8
Aliases	RC1; HPC3; polycomb 3; Pc class 3 homolog (Drosophila); chromobox homolog 8 (Drosophila Pc class); Pc class ......
Location	17q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

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Domain

PF17218 CBX family C-terminal motif
PF00385 Chromo (CHRromatin Organisation MOdifier) domain

Function

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification read	#	H3K9me3, H3K27me3	#	21047797

> Gene Ontology [ TOP ]
Biological Process	GO:0000302 response to reactive oxygen species GO:0006282 regulation of DNA repair GO:0006979 response to oxidative stress GO:0010035 response to inorganic substance GO:0010712 regulation of collagen metabolic process GO:0010714 positive regulation of collagen metabolic process GO:0016570 histone modification GO:0016574 histone ubiquitination GO:0016925 protein sumoylation GO:0018205 peptidyl-lysine modification GO:0032963 collagen metabolic process GO:0032964 collagen biosynthetic process GO:0032965 regulation of collagen biosynthetic process GO:0032967 positive regulation of collagen biosynthetic process GO:0034599 cellular response to oxidative stress GO:0034614 cellular response to reactive oxygen species GO:0042542 response to hydrogen peroxide GO:0044236 multicellular organism metabolic process GO:0044246 regulation of multicellular organismal metabolic process GO:0044253 positive regulation of multicellular organismal metabolic process GO:0044259 multicellular organismal macromolecule metabolic process GO:0045739 positive regulation of DNA repair GO:0051052 regulation of DNA metabolic process GO:0051054 positive regulation of DNA metabolic process GO:0070301 cellular response to hydrogen peroxide GO:2001020 regulation of response to DNA damage stimulus GO:2001022 positive regulation of response to DNA damage stimulus
Molecular Function	GO:0003727 single-stranded RNA binding GO:0035064 methylated histone binding GO:0042393 histone binding GO:0055103 ligase regulator activity GO:0055106 ubiquitin-protein transferase regulator activity GO:0097027 ubiquitin-protein transferase activator activity
Cellular Component	GO:0000151 ubiquitin ligase complex GO:0000152 nuclear ubiquitin ligase complex GO:0000785 chromatin GO:0000790 nuclear chromatin GO:0000792 heterochromatin GO:0031519 PcG protein complex GO:0035102 PRC1 complex GO:0044454 nuclear chromosome part

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-2559583: Cellular Senescence R-HSA-2262752: Cellular responses to stress R-HSA-392499: Metabolism of proteins R-HSA-2559580: Oxidative Stress Induced Senescence R-HSA-597592: Post-translational protein modification R-HSA-3108232: SUMO E3 ligases SUMOylate target proteins R-HSA-2990846: SUMOylation R-HSA-3108214: SUMOylation of DNA damage response and repair proteins R-HSA-4570464: SUMOylation of RNA binding proteins

> KEGG and Reactome Pathway

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KEGG

Reactome

R-HSA-2559583: Cellular Senescence
R-HSA-2262752: Cellular responses to stress
R-HSA-392499: Metabolism of proteins
R-HSA-2559580: Oxidative Stress Induced Senescence
R-HSA-597592: Post-translational protein modification
R-HSA-3108232: SUMO E3 ligases SUMOylate target proteins
R-HSA-2990846: SUMOylation
R-HSA-3108214: SUMOylation of DNA damage response and repair proteins
R-HSA-4570464: SUMOylation of RNA binding proteins

Summary
Symbol	CBX8
Name	chromobox 8
Aliases	RC1; HPC3; polycomb 3; Pc class 3 homolog (Drosophila); chromobox homolog 8 (Drosophila Pc class); Pc class ......
Location	17q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

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COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM4480327	c.240C>T	p.L80L	Substitution - coding silent	Skin
COSM5594358	c.873C>T	p.F291F	Substitution - coding silent	Skin
COSM1386948	c.956_957insG	p.L320fs*38	Insertion - Frameshift	Large_intestine
COSM297939	c.942_943insC	p.S315fs*43	Insertion - Frameshift	Large_intestine
COSM3665219	c.463G>C	p.D155H	Substitution - Missense	Oesophagus
COSM1386949	c.956delG	p.G319fs*37	Deletion - Frameshift	Large_intestine
COSM4070312	c.106T>C	p.S36P	Substitution - Missense	Stomach
COSM4617823	c.398C>T	p.A133V	Substitution - Missense	Large_intestine
COSM5564273	c.362G>T	p.R121L	Substitution - Missense	Prostate
COSM6002785	c.679A>G	p.K227E	Substitution - Missense	Prostate
COSM985405	c.661G>A	p.G221S	Substitution - Missense	Endometrium
COSM3717734	c.431C>T	p.A144V	Substitution - Missense	Liver
COSM5722704	c.433G>A	p.E145K	Substitution - Missense	Skin
COSM5603084	c.629C>T	p.P210L	Substitution - Missense	Skin
COSM1303438	c.164C>T	p.A55V	Substitution - Missense	Urinary_tract
COSM3378381	c.843G>A	p.P281P	Substitution - coding silent	Pancreas
COSM4512487	c.904C>T	p.P302S	Substitution - Missense	Skin
COSM4648094	c.874C>A	p.L292M	Substitution - Missense	Large_intestine
COSM5722704	c.433G>A	p.E145K	Substitution - Missense	Skin
COSM3820849	c.146T>C	p.L49P	Substitution - Missense	Breast
COSM437708	c.950G>T	p.G317V	Substitution - Missense	Large_intestine
COSM3820847	c.1081G>C	p.V361L	Substitution - Missense	Breast
COSM707741	c.964C>G	p.R322G	Substitution - Missense	Lung
COSM437708	c.950G>T	p.G317V	Substitution - Missense	Thyroid
COSM4139919	c.85C>G	p.L29V	Substitution - Missense	Ovary
COSM1180856	c.942delC	p.S315fs*41	Deletion - Frameshift	Large_intestine
COSM2802804	c.570C>T	p.S190S	Substitution - coding silent	Large_intestine
COSM196271	c.1155delT	p.F385fs*>5	Deletion - Frameshift	Large_intestine
COSM115757	c.796C>T	p.P266S	Substitution - Missense	Ovary
COSM985404	c.696C>T	p.D232D	Substitution - coding silent	Endometrium
COSM985403	c.901G>T	p.D301Y	Substitution - Missense	Endometrium
COSM4669585	c.202G>T	p.G68C	Substitution - Missense	Large_intestine
COSM4545662	c.382G>A	p.G128S	Substitution - Missense	Skin
COSM4558628	c.774G>T	p.L258L	Substitution - coding silent	Skin
COSM1386952	c.657C>T	p.S219S	Substitution - coding silent	Large_intestine
COSM1386955	c.60C>T	p.R20R	Substitution - coding silent	Large_intestine
COSM1238436	c.1055G>C	p.S352T	Substitution - Missense	Oesophagus
COSM4070311	c.172G>C	p.E58Q	Substitution - Missense	Stomach
COSM226804	c.383G>A	p.G128D	Substitution - Missense	Skin
COSM5722704	c.433G>A	p.E145K	Substitution - Missense	Skin
COSM1386953	c.215G>A	p.R72H	Substitution - Missense	Skin
COSM196271	c.1155delT	p.F385fs*>5	Deletion - Frameshift	Large_intestine
COSM3523237	c.625G>A	p.D209N	Substitution - Missense	Skin
COSM2802812	c.162C>T	p.L54L	Substitution - coding silent	Large_intestine
COSM3796180	c.1144C>T	p.Q382*	Substitution - Nonsense	Urinary_tract
COSM3717734	c.431C>T	p.A144V	Substitution - Missense	Liver
COSM5722703	c.1004C>T	p.A335V	Substitution - Missense	Skin
COSM3403340	c.329C>T	p.S110L	Substitution - Missense	Central_nervous_system
COSM5951268	c.955_956insG	p.L320fs*38	Insertion - Frameshift	Oesophagus
COSM985407	c.209A>G	p.K70R	Substitution - Missense	Endometrium
COSM3523238	c.574C>T	p.P192S	Substitution - Missense	Skin
COSM5722704	c.433G>A	p.E145K	Substitution - Missense	Skin
COSM215730	c.539G>A	p.R180Q	Substitution - Missense	Prostate
COSM3820848	c.913A>C	p.T305P	Substitution - Missense	Breast
COSM3958885	c.761A>G	p.Q254R	Substitution - Missense	Lung
COSM4070310	c.295G>C	p.A99P	Substitution - Missense	Stomach
COSM1710870	c.860A>T	p.H287L	Substitution - Missense	Skin
COSM4515041	c.996C>A	p.S332S	Substitution - coding silent	Skin
COSM3820846	c.1161G>T	p.E387D	Substitution - Missense	Breast
COSM6008328	c.1139C>T	p.T380M	Substitution - Missense	Prostate
COSM215730	c.539G>A	p.R180Q	Substitution - Missense	Central_nervous_system
COSM5722703	c.1004C>T	p.A335V	Substitution - Missense	Skin
COSM4602290	c.916C>T	p.R306W	Substitution - Missense	Upper_aerodigestive_tract
COSM5429068	c.648C>T	p.G216G	Substitution - coding silent	Oesophagus
COSM3523236	c.995C>T	p.S332F	Substitution - Missense	Skin
COSM437707	c.986G>A	p.G329E	Substitution - Missense	Breast
COSM1386948	c.956_957insG	p.L320fs*38	Insertion - Frameshift	Large_intestine
COSM1130128	c.768G>A	p.S256S	Substitution - coding silent	Prostate
COSM4497724	c.502C>T	p.R168*	Substitution - Nonsense	Skin
COSM5387551	c.1042G>A	p.E348K	Substitution - Missense	Skin
COSM1386948	c.956_957insG	p.L320fs*38	Insertion - Frameshift	Large_intestine
COSM5603085	c.1011C>T	p.I337I	Substitution - coding silent	Skin
COSM4545074	c.36G>A	p.A12A	Substitution - coding silent	Skin
COSM4456917	c.1027C>T	p.L343L	Substitution - coding silent	Skin
COSM1386950	c.953G>A	p.G318E	Substitution - Missense	Large_intestine
COSM1386949	c.956delG	p.G319fs*37	Deletion - Frameshift	Soft_tissue
COSM5571321	c.1084G>T	p.V362L	Substitution - Missense	Prostate
COSM437708	c.950G>T	p.G317V	Substitution - Missense	Liver
COSM1386951	c.949G>A	p.G317R	Substitution - Missense	Large_intestine
COSM2802798	c.699C>T	p.D233D	Substitution - coding silent	Large_intestine
COSM4130753	c.553G>A	p.V185M	Substitution - Missense	Thyroid
COSM3523235	c.1100C>T	p.T367I	Substitution - Missense	Skin
COSM437709	c.944G>A	p.S315N	Substitution - Missense	Breast
COSM1610926	c.486A>C	p.R162R	Substitution - coding silent	Liver
COSM985408	c.119G>T	p.S40I	Substitution - Missense	Endometrium
COSM1386953	c.215G>A	p.R72H	Substitution - Missense	Large_intestine
COSM985406	c.520C>T	p.R174C	Substitution - Missense	Endometrium
COSM1386954	c.214C>T	p.R72C	Substitution - Missense	Large_intestine
COSM1386947	c.1077G>A	p.E359E	Substitution - coding silent	Large_intestine
COSM4487506	c.319C>T	p.P107S	Substitution - Missense	Skin
COSM3523234	c.1116C>T	p.T372T	Substitution - coding silent	Skin
COSM1610926	c.486A>C	p.R162R	Substitution - coding silent	Liver
COSM3523239	c.144C>T	p.I48I	Substitution - coding silent	Skin
COSM5722703	c.1004C>T	p.A335V	Substitution - Missense	Skin
COSM5722703	c.1004C>T	p.A335V	Substitution - Missense	Skin
COSM4437308	c.878A>C	p.E293A	Substitution - Missense	Oesophagus
COSM1199740	c.965G>A	p.R322Q	Substitution - Missense	Large_intestine
COSM1386949	c.956delG	p.G319fs*37	Deletion - Frameshift	Large_intestine
COSM1386949	c.956delG	p.G319fs*37	Deletion - Frameshift	Stomach
COSM150871	c.1143_1156del14	p.D381fs*>5	Deletion - Frameshift	Stomach
COSM1180856	c.942delC	p.S315fs*41	Deletion - Frameshift	Large_intestine
COSM5004624	c.662G>A	p.G221D	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1386954	c.214C>T	p.R72C	Substitution - Missense	Stomach
COSM2802801	c.611G>A	p.R204Q	Substitution - Missense	Large_intestine
COSM4652932	c.166G>A	p.A56T	Substitution - Missense	Large_intestine
COSM708778	c.899T>C	p.L300P	Substitution - Missense	Lung
COSM4426909	c.111G>A	p.Q37Q	Substitution - coding silent	Oesophagus
COSM279596	c.1166G>T	p.R389I	Substitution - Missense	Large_intestine
COSM5808624	c.1072C>T	p.L358L	Substitution - coding silent	Liver
COSM4437309	c.877G>T	p.E293*	Substitution - Nonsense	Oesophagus
COSM3890608	c.370C>T	p.L124F	Substitution - Missense	Skin

> Text Mining based Variations [ TOP ]
There is no record for CBX8.

Summary
Symbol	CBX8
Name	chromobox 8
Aliases	RC1; HPC3; polycomb 3; Pc class 3 homolog (Drosophila); chromobox homolog 8 (Drosophila Pc class); Pc class ......
Location	17q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

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Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
Q9HC52	130	S	Phosphoserine	-	No	None detected
Q9HC52	191	S	Phosphoserine	-	No	None detected
Q9HC52	256	S	Phosphoserine	-	No	None detected
Q9HC52	265	S	Phosphoserine	-	No	None detected
Q9HC52	311	S	Phosphoserine	-	No	None detected
Q9HC52	332	S	Phosphoserine	-	Yes	p.SL332fs (cancer: STAD)
Q9HC52	352	S	Phosphoserine	-	No	None detected

Summary
Symbol	CBX8
Name	chromobox 8
Aliases	RC1; HPC3; polycomb 3; Pc class 3 homolog (Drosophila); chromobox homolog 8 (Drosophila Pc class); Pc class ......
Location	17q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

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Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	1.939	3.189	1.52	2.32e-17	Over
BRCA	Breast invasive carcinoma	112	1100	1.696	3.022	1.458	1.09e-56	Over
CESC	Cervical and endocervical cancers	3	306	1.558	3.281	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	2.072	3.772	1.684	7.13e-55	Over
ESCA	Esophageal carcinoma	11	185	1.162	2.274	1.262	2.38e-07	Over
GBM	Glioblastoma multiforme	5	166	1.822	3.043	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	1.939	2.609	0.897	5.25e-16	Over
KIRC	Kidney renal clear cell carcinoma	72	534	1.987	2.257	0.186	0.042	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	2.322	2.961	0.615	3.44e-07	Over
LAML	Acute Myeloid Leukemia	0	173	NA	1.81	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	2.888	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	1.902	2.941	1.247	1.14e-22	Over
LUAD	Lung adenocarcinoma	59	517	1.971	3.33	1.424	1.25e-41	Over
LUSC	Lung squamous cell carcinoma	51	501	1.814	3.175	1.477	4.99e-41	Over
OV	Ovarian serous cystadenocarcinoma	0	307	NA	3.215	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	2.93	2.633	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	2.697	2.814	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	2.06	2.805	0.715	2.41e-16	Over
READ	Rectum adenocarcinoma	10	167	1.882	3.673	1.905	7.41e-22	Over
SARC	Sarcoma	2	263	2.464	2.977	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	3.753	3.792	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	1.867	2.598	0.952	5.98e-10	Over
TGCT	Testicular Germ Cell Tumors	0	156	NA	3.228	NA	NA	NA
THCA	Thyroid carcinoma	59	509	2.206	2.614	0.403	4.93e-07	NS
THYM	Thymoma	2	120	2.789	2.915	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	2.326	3.529	1.223	4.16e-21	Over

> Cancer Cell Line Encyclopedia (CCLE)

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Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	5.9
Autonomic ganglia	CHP212	6.4
Autonomic ganglia	IMR32	6.8
Autonomic ganglia	KELLY	6.7
Autonomic ganglia	KPNRTBM1	5.5
Autonomic ganglia	KPNSI9S	5.6
Autonomic ganglia	KPNYN	5.4
Autonomic ganglia	MHHNB11	7.5
Autonomic ganglia	NB1	6.4
Autonomic ganglia	NH6	5.8
Autonomic ganglia	SHSY5Y	6.1
Autonomic ganglia	SIMA	5.9
Autonomic ganglia	SKNAS	5.9
Autonomic ganglia	SKNBE2	6
Autonomic ganglia	SKNDZ	6.3
Autonomic ganglia	SKNFI	5.8
Autonomic ganglia	SKNSH	5.6
Biliary tract	HUCCT1	5.9
Biliary tract	HUH28	5.4
Biliary tract	SNU1079	5.7
Biliary tract	SNU1196	5.9
Biliary tract	SNU245	6.1
Biliary tract	SNU308	5.7
Biliary tract	SNU478	6
Bone	143B	6.1
Bone	A673	6.7
Bone	CADOES1	5.8
Bone	CAL78	5.3
Bone	G292CLONEA141B1	5.6
Bone	HOS	5.7
Bone	HS706T	5.8
Bone	HS737T	5.6
Bone	HS819T	5.5
Bone	HS821T	5.5
Bone	HS822T	5.5
Bone	HS863T	5.5
Bone	HS870T	5.5
Bone	HS888T	5.9
Bone	MG63	6.2
Bone	MHHES1	6.6
Bone	OUMS27	5.3
Bone	RDES	6.7
Bone	SJSA1	6.4
Bone	SKES1	6.3
Bone	SKNMC	7.1
Bone	SW1353	5.3
Bone	T173	5.6
Bone	TC71	6.4
Bone	U2OS	6.5
Breast	AU565	6.8
Breast	BT20	6.5
Breast	BT474	5.7
Breast	BT483	5.6
Breast	BT549	6.4
Breast	CAL120	5.6
Breast	CAL148	5.2
Breast	CAL51	6.1
Breast	CAL851	5.9
Breast	CAMA1	5.6
Breast	DU4475	6.8
Breast	EFM192A	6.2
Breast	EFM19	6
Breast	EVSAT	6.4
Breast	HCC1143	6.4
Breast	HCC1187	6.1
Breast	HCC1395	6.1
Breast	HCC1419	6.4
Breast	HCC1428	6.3
Breast	HCC1500	6.1
Breast	HCC1569	5.5
Breast	HCC1599	5.8
Breast	HCC1806	6.3
Breast	HCC1937	5.5
Breast	HCC1954	5.7
Breast	HCC202	6
Breast	HCC2157	5.9
Breast	HCC2218	5.9
Breast	HCC38	5.7
Breast	HCC70	5.5
Breast	HDQP1	5.8
Breast	HMC18	5.8
Breast	HS274T	5.4
Breast	HS281T	5.5
Breast	HS343T	5.4
Breast	HS578T	5.9
Breast	HS606T	5.6
Breast	HS739T	5.4
Breast	HS742T	5.5
Breast	JIMT1	6
Breast	KPL1	5.9
Breast	MCF7	6
Breast	MDAMB134VI	5.3
Breast	MDAMB157	5.7
Breast	MDAMB175VII	5.4
Breast	MDAMB231	5.7
Breast	MDAMB361	5.9
Breast	MDAMB415	5.4
Breast	MDAMB436	6.1
Breast	MDAMB453	6.2
Breast	MDAMB468	6.2
Breast	SKBR3	6.9
Breast	T47D	5.7
Breast	UACC812	6.3
Breast	UACC893	6.1
Breast	YMB1	5.8
Breast	ZR751	5.6
Breast	ZR7530	5.7
Central nervous system	1321N1	6.1
Central nervous system	42MGBA	6.3
Central nervous system	8MGBA	5.6
Central nervous system	A172	5.8
Central nervous system	AM38	5.6
Central nervous system	BECKER	6.1
Central nervous system	CAS1	5.4
Central nervous system	CCFSTTG1	5.8
Central nervous system	D283MED	6.8
Central nervous system	D341MED	5.7
Central nervous system	DAOY	5.3
Central nervous system	DBTRG05MG	5.6
Central nervous system	DKMG	5.8
Central nervous system	GAMG	5.6
Central nervous system	GB1	6.4
Central nervous system	GI1	6.2
Central nervous system	GMS10	5.9
Central nervous system	GOS3	6.1
Central nervous system	H4	6.4
Central nervous system	HS683	5.5
Central nervous system	KALS1	5.5
Central nervous system	KG1C	5.2
Central nervous system	KNS42	5.9
Central nervous system	KNS60	5.7
Central nervous system	KNS81	5.3
Central nervous system	KS1	5.8
Central nervous system	LN18	6.6
Central nervous system	LN229	5.8
Central nervous system	M059K	6
Central nervous system	MOGGCCM	5.6
Central nervous system	MOGGUVW	5.7
Central nervous system	NMCG1	5.5
Central nervous system	ONS76	5.8
Central nervous system	SF126	6
Central nervous system	SF295	5.8
Central nervous system	SNB19	5.8
Central nervous system	SNU1105	5.6
Central nervous system	SNU201	5.8
Central nervous system	SNU466	5.8
Central nervous system	SNU489	5.8
Central nervous system	SNU626	6.1
Central nervous system	SNU738	5.8
Central nervous system	SW1088	6
Central nervous system	SW1783	5.8
Central nervous system	T98G	6.7
Central nervous system	TM31	5.4
Central nervous system	U118MG	6.2
Central nervous system	U138MG	5.7
Central nervous system	U251MG	5.6
Central nervous system	U87MG	6.1
Central nervous system	YH13	5.9
Central nervous system	YKG1	5.8
Endometrium	AN3CA	6.6
Endometrium	COLO684	7
Endometrium	EFE184	5.6
Endometrium	EN	6.2
Endometrium	ESS1	5.6
Endometrium	HEC108	6.1
Endometrium	HEC151	6.3
Endometrium	HEC1A	5.7
Endometrium	HEC1B	5.7
Endometrium	HEC251	6.2
Endometrium	HEC265	5.4
Endometrium	HEC50B	5.7
Endometrium	HEC59	5.9
Endometrium	HEC6	5.4
Endometrium	ISHIKAWAHERAKLIO02ER	5.7
Endometrium	JHUEM1	6
Endometrium	JHUEM2	5.9
Endometrium	JHUEM3	5
Endometrium	KLE	5.6
Endometrium	MFE280	5.7
Endometrium	MFE296	6.2
Endometrium	MFE319	5.6
Endometrium	RL952	6.1
Endometrium	SNGM	5.7
Endometrium	SNU1077	5.5
Endometrium	SNU685	5.9
Endometrium	TEN	5.9
Haematopoietic and lymphoid	697	5.8
Haematopoietic and lymphoid	A3KAW	5.5
Haematopoietic and lymphoid	A4FUK	5.8
Haematopoietic and lymphoid	ALLSIL	6.2
Haematopoietic and lymphoid	AML193	5.5
Haematopoietic and lymphoid	AMO1	5.9
Haematopoietic and lymphoid	BCP1	6.3
Haematopoietic and lymphoid	BDCM	5.5
Haematopoietic and lymphoid	BL41	5.8
Haematopoietic and lymphoid	BL70	5.6
Haematopoietic and lymphoid	BV173	6.4
Haematopoietic and lymphoid	CA46	5.8
Haematopoietic and lymphoid	CI1	5.7
Haematopoietic and lymphoid	CMK115	5.4
Haematopoietic and lymphoid	CMK86	6.1
Haematopoietic and lymphoid	CMK	5.8
Haematopoietic and lymphoid	CMLT1	6.1
Haematopoietic and lymphoid	COLO775	6.5
Haematopoietic and lymphoid	DAUDI	5.7
Haematopoietic and lymphoid	DB	5.8
Haematopoietic and lymphoid	DEL	5.3
Haematopoietic and lymphoid	DND41	6.5
Haematopoietic and lymphoid	DOHH2	6.1
Haematopoietic and lymphoid	EB1	6.1
Haematopoietic and lymphoid	EB2	5.6
Haematopoietic and lymphoid	EHEB	5.5
Haematopoietic and lymphoid	EJM	5.1
Haematopoietic and lymphoid	EM2	6.1
Haematopoietic and lymphoid	EOL1	5.8
Haematopoietic and lymphoid	F36P	5.9
Haematopoietic and lymphoid	GA10	6
Haematopoietic and lymphoid	GDM1	5.5
Haematopoietic and lymphoid	GRANTA519	5.9
Haematopoietic and lymphoid	HDLM2	5.7
Haematopoietic and lymphoid	HDMYZ	5.6
Haematopoietic and lymphoid	HEL9217	5.4
Haematopoietic and lymphoid	HEL	5.2
Haematopoietic and lymphoid	HH	6.6
Haematopoietic and lymphoid	HL60	6
Haematopoietic and lymphoid	HPBALL	5.8
Haematopoietic and lymphoid	HS604T	5.7
Haematopoietic and lymphoid	HS611T	5.8
Haematopoietic and lymphoid	HS616T	5.4
Haematopoietic and lymphoid	HS751T	5.8
Haematopoietic and lymphoid	HT	5.7
Haematopoietic and lymphoid	HTK	6.3
Haematopoietic and lymphoid	HUNS1	6.3
Haematopoietic and lymphoid	HUT102	5.8
Haematopoietic and lymphoid	HUT78	6.2
Haematopoietic and lymphoid	JEKO1	6.2
Haematopoietic and lymphoid	JK1	5.3
Haematopoietic and lymphoid	JM1	6
Haematopoietic and lymphoid	JURKAT	5.5
Haematopoietic and lymphoid	JURLMK1	5.5
Haematopoietic and lymphoid	JVM2	5.7
Haematopoietic and lymphoid	JVM3	6.4
Haematopoietic and lymphoid	K562	6.1
Haematopoietic and lymphoid	KARPAS299	5.6
Haematopoietic and lymphoid	KARPAS422	6.5
Haematopoietic and lymphoid	KARPAS620	6
Haematopoietic and lymphoid	KASUMI1	6
Haematopoietic and lymphoid	KASUMI2	5.4
Haematopoietic and lymphoid	KASUMI6	5.8
Haematopoietic and lymphoid	KCL22	5.6
Haematopoietic and lymphoid	KE37	5.5
Haematopoietic and lymphoid	KE97	6
Haematopoietic and lymphoid	KG1	5.4
Haematopoietic and lymphoid	KHM1B	5.9
Haematopoietic and lymphoid	KIJK	5.9
Haematopoietic and lymphoid	KMH2	5.5
Haematopoietic and lymphoid	KMM1	5.7
Haematopoietic and lymphoid	KMS11	5.9
Haematopoietic and lymphoid	KMS12BM	5.9
Haematopoietic and lymphoid	KMS18	6.3
Haematopoietic and lymphoid	KMS20	5.4
Haematopoietic and lymphoid	KMS21BM	6
Haematopoietic and lymphoid	KMS26	5.5
Haematopoietic and lymphoid	KMS27	6.4
Haematopoietic and lymphoid	KMS28BM	5.4
Haematopoietic and lymphoid	KMS34	5.4
Haematopoietic and lymphoid	KO52	5.1
Haematopoietic and lymphoid	KOPN8	6.5
Haematopoietic and lymphoid	KU812	5.5
Haematopoietic and lymphoid	KYO1	6.4
Haematopoietic and lymphoid	L1236	5.8
Haematopoietic and lymphoid	L363	6.1
Haematopoietic and lymphoid	L428	5.5
Haematopoietic and lymphoid	L540	5.4
Haematopoietic and lymphoid	LAMA84	5.9
Haematopoietic and lymphoid	LOUCY	6.5
Haematopoietic and lymphoid	LP1	5.6
Haematopoietic and lymphoid	M07E	5.3
Haematopoietic and lymphoid	MC116	6.3
Haematopoietic and lymphoid	ME1	6.1
Haematopoietic and lymphoid	MEC1	5.2
Haematopoietic and lymphoid	MEC2	5.6
Haematopoietic and lymphoid	MEG01	5.8
Haematopoietic and lymphoid	MHHCALL2	5.6
Haematopoietic and lymphoid	MHHCALL3	6
Haematopoietic and lymphoid	MHHCALL4	5.6
Haematopoietic and lymphoid	MINO	6.2
Haematopoietic and lymphoid	MJ	5.9
Haematopoietic and lymphoid	MM1S	5.8
Haematopoietic and lymphoid	MOLM13	6.4
Haematopoietic and lymphoid	MOLM16	5.3
Haematopoietic and lymphoid	MOLM6	6
Haematopoietic and lymphoid	MOLP2	6.3
Haematopoietic and lymphoid	MOLP8	5.9
Haematopoietic and lymphoid	MOLT13	5.9
Haematopoietic and lymphoid	MOLT16	5.8
Haematopoietic and lymphoid	MOLT4	6.1
Haematopoietic and lymphoid	MONOMAC1	5.7
Haematopoietic and lymphoid	MONOMAC6	5.7
Haematopoietic and lymphoid	MOTN1	6
Haematopoietic and lymphoid	MUTZ5	5.8
Haematopoietic and lymphoid	MV411	6.4
Haematopoietic and lymphoid	NALM19	5.6
Haematopoietic and lymphoid	NALM1	5.6
Haematopoietic and lymphoid	NALM6	5.6
Haematopoietic and lymphoid	NAMALWA	6.5
Haematopoietic and lymphoid	NB4	5.9
Haematopoietic and lymphoid	NCIH929	6.4
Haematopoietic and lymphoid	NCO2	5.6
Haematopoietic and lymphoid	NOMO1	5.4
Haematopoietic and lymphoid	NUDHL1	5.9
Haematopoietic and lymphoid	NUDUL1	5.7
Haematopoietic and lymphoid	OCIAML2	5.8
Haematopoietic and lymphoid	OCIAML3	6.4
Haematopoietic and lymphoid	OCIAML5	5.7
Haematopoietic and lymphoid	OCILY10	6.1
Haematopoietic and lymphoid	OCILY19	6.2
Haematopoietic and lymphoid	OCILY3	5.9
Haematopoietic and lymphoid	OCIM1	5.5
Haematopoietic and lymphoid	OPM2	5.4
Haematopoietic and lymphoid	P12ICHIKAWA	6
Haematopoietic and lymphoid	P31FUJ	6.2
Haematopoietic and lymphoid	P3HR1	6.2
Haematopoietic and lymphoid	PCM6	6
Haematopoietic and lymphoid	PEER	6
Haematopoietic and lymphoid	PF382	5.8
Haematopoietic and lymphoid	PFEIFFER	5.9
Haematopoietic and lymphoid	PL21	5.6
Haematopoietic and lymphoid	RAJI	6.1
Haematopoietic and lymphoid	RCHACV	5.1
Haematopoietic and lymphoid	REC1	6.1
Haematopoietic and lymphoid	REH	6
Haematopoietic and lymphoid	RI1	6.2
Haematopoietic and lymphoid	RL	6
Haematopoietic and lymphoid	RPMI8226	5.7
Haematopoietic and lymphoid	RPMI8402	5.9
Haematopoietic and lymphoid	RS411	5.9
Haematopoietic and lymphoid	SEM	5.7
Haematopoietic and lymphoid	SET2	5.3
Haematopoietic and lymphoid	SIGM5	6
Haematopoietic and lymphoid	SKM1	5.6
Haematopoietic and lymphoid	SKMM2	5.8
Haematopoietic and lymphoid	SR786	5.7
Haematopoietic and lymphoid	ST486	5.7
Haematopoietic and lymphoid	SUDHL10	6.5
Haematopoietic and lymphoid	SUDHL1	5.8
Haematopoietic and lymphoid	SUDHL4	6.4
Haematopoietic and lymphoid	SUDHL5	5.8
Haematopoietic and lymphoid	SUDHL6	6.2
Haematopoietic and lymphoid	SUDHL8	6.2
Haematopoietic and lymphoid	SUPB15	5.6
Haematopoietic and lymphoid	SUPHD1	5.7
Haematopoietic and lymphoid	SUPM2	5.7
Haematopoietic and lymphoid	SUPT11	6.4
Haematopoietic and lymphoid	SUPT1	5.9
Haematopoietic and lymphoid	TALL1	5.8
Haematopoietic and lymphoid	TF1	5.6
Haematopoietic and lymphoid	THP1	5.8
Haematopoietic and lymphoid	TO175T	5.5
Haematopoietic and lymphoid	TOLEDO	5.9
Haematopoietic and lymphoid	U266B1	5.8
Haematopoietic and lymphoid	U937	5.6
Haematopoietic and lymphoid	UT7	5.3
Haematopoietic and lymphoid	WSUDLCL2	6.4
Kidney	769P	5.6
Kidney	786O	5.7
Kidney	A498	5.7
Kidney	A704	6
Kidney	ACHN	5.4
Kidney	BFTC909	5.3
Kidney	CAKI1	5.8
Kidney	CAKI2	6.4
Kidney	CAL54	5.7
Kidney	KMRC1	5.9
Kidney	KMRC20	5
Kidney	KMRC2	5.5
Kidney	KMRC3	5.5
Kidney	OSRC2	5.8
Kidney	RCC10RGB	5.1
Kidney	SNU1272	5.3
Kidney	SNU349	5.2
Kidney	TUHR10TKB	5.3
Kidney	TUHR14TKB	5.3
Kidney	TUHR4TKB	5.5
Kidney	VMRCRCW	5.7
Kidney	VMRCRCZ	5.4
Large intestine	C2BBE1	6
Large intestine	CCK81	5.8
Large intestine	CL11	5.4
Large intestine	CL14	6
Large intestine	CL34	5.8
Large intestine	CL40	6.1
Large intestine	COLO205	5.7
Large intestine	COLO320	5.9
Large intestine	COLO678	6.2
Large intestine	CW2	6.5
Large intestine	DLD1	6.2
Large intestine	GP2D	5.9
Large intestine	HCC56	6.1
Large intestine	HCT116	6.7
Large intestine	HCT15	6.2
Large intestine	HS675T	5.3
Large intestine	HS698T	5.5
Large intestine	HT115	6.1
Large intestine	HT29	6.9
Large intestine	HT55	5.7
Large intestine	KM12	6.1
Large intestine	LOVO	6.1
Large intestine	LS1034	6.2
Large intestine	LS123	5.8
Large intestine	LS180	6.3
Large intestine	LS411N	6.1
Large intestine	LS513	6
Large intestine	MDST8	6.1
Large intestine	NCIH508	6
Large intestine	NCIH716	5.5
Large intestine	NCIH747	5.8
Large intestine	OUMS23	6
Large intestine	RCM1	5.6
Large intestine	RKO	6.1
Large intestine	SKCO1	6.4
Large intestine	SNU1040	6.1
Large intestine	SNU1197	6
Large intestine	SNU175	5.9
Large intestine	SNU283	6.3
Large intestine	SNU407	6.1
Large intestine	SNU503	6
Large intestine	SNU61	5.8
Large intestine	SNU81	6.3
Large intestine	SNUC1	6.5
Large intestine	SNUC2A	5.8
Large intestine	SNUC4	5.7
Large intestine	SNUC5	6
Large intestine	SW1116	5.7
Large intestine	SW1417	5.7
Large intestine	SW1463	5.6
Large intestine	SW403	6
Large intestine	SW480	5.9
Large intestine	SW48	6.5
Large intestine	SW620	6.2
Large intestine	SW837	6.2
Large intestine	SW948	6.2
Large intestine	T84	6
Liver	ALEXANDERCELLS	6.5
Liver	C3A	5.9
Liver	HEP3B217	6
Liver	HEPG2	6.7
Liver	HLE	6.1
Liver	HLF	6
Liver	HUH1	6.2
Liver	HUH6	5.8
Liver	HUH7	5.5
Liver	JHH1	6.6
Liver	JHH2	5.9
Liver	JHH4	5.9
Liver	JHH5	6.5
Liver	JHH6	5.9
Liver	JHH7	6.1
Liver	LI7	6.2
Liver	PLCPRF5	6.6
Liver	SKHEP1	5.8
Liver	SNU182	6.5
Liver	SNU387	6.2
Liver	SNU398	6.7
Liver	SNU423	5.9
Liver	SNU449	6
Liver	SNU475	6.2
Liver	SNU761	5.6
Liver	SNU878	5.7
Liver	SNU886	6.3
Lung	A549	6.7
Lung	ABC1	5.5
Lung	BEN	6.2
Lung	CAL12T	5.7
Lung	CALU1	6
Lung	CALU3	5.5
Lung	CALU6	6.3
Lung	CHAGOK1	5.8
Lung	COLO668	5.7
Lung	COLO699	6.2
Lung	CORL105	5.8
Lung	CORL23	6.6
Lung	CORL24	5.7
Lung	CORL279	7
Lung	CORL311	5.7
Lung	CORL47	5.8
Lung	CORL51	5.6
Lung	CORL88	5.9
Lung	CORL95	5.8
Lung	CPCN	6
Lung	DMS114	6.9
Lung	DMS153	5.6
Lung	DMS273	5.6
Lung	DMS454	6.1
Lung	DMS53	5.5
Lung	DMS79	5.5
Lung	DV90	6.8
Lung	EBC1	6.1
Lung	EPLC272H	5.7
Lung	HARA	6.4
Lung	HCC1171	5.4
Lung	HCC1195	6
Lung	HCC15	5.6
Lung	HCC2279	5.8
Lung	HCC2935	6.2
Lung	HCC33	5.6
Lung	HCC366	6
Lung	HCC4006	5.9
Lung	HCC44	5.9
Lung	HCC78	5.8
Lung	HCC827	5.9
Lung	HCC95	5.8
Lung	HLC1	6
Lung	HLFA	5.5
Lung	HS229T	5.5
Lung	HS618T	5.8
Lung	IALM	5.6
Lung	KNS62	6
Lung	LC1F	6.2
Lung	LC1SQSF	5.9
Lung	LCLC103H	5.5
Lung	LCLC97TM1	5.5
Lung	LK2	6.2
Lung	LOUNH91	5.9
Lung	LU65	5.7
Lung	LU99	5.5
Lung	LUDLU1	6
Lung	LXF289	6
Lung	MORCPR	6.1
Lung	NCIH1048	5.5
Lung	NCIH1092	5.9
Lung	NCIH1105	5.7
Lung	NCIH1155	5.7
Lung	NCIH1184	6.3
Lung	NCIH1299	6.2
Lung	NCIH1339	5.9
Lung	NCIH1341	5.5
Lung	NCIH1355	6.2
Lung	NCIH1373	6
Lung	NCIH1385	6.2
Lung	NCIH1395	6.3
Lung	NCIH1435	6.3
Lung	NCIH1436	5.3
Lung	NCIH1437	6.4
Lung	NCIH146	5.7
Lung	NCIH1563	5.8
Lung	NCIH1568	6.4
Lung	NCIH1573	6.1
Lung	NCIH1581	6.2
Lung	NCIH1618	6.1
Lung	NCIH1623	6.5
Lung	NCIH1648	5.6
Lung	NCIH1650	5.9
Lung	NCIH1651	5.8
Lung	NCIH1666	5.8
Lung	NCIH1693	5.6
Lung	NCIH1694	6
Lung	NCIH1703	5.6
Lung	NCIH1734	5.8
Lung	NCIH1755	6.3
Lung	NCIH1781	5.7
Lung	NCIH1792	5.9
Lung	NCIH1793	5.9
Lung	NCIH1836	5.4
Lung	NCIH1838	6.1
Lung	NCIH1869	6
Lung	NCIH1876	5.5
Lung	NCIH1915	5.8
Lung	NCIH1930	5.6
Lung	NCIH1944	6.1
Lung	NCIH1963	6.1
Lung	NCIH196	5.9
Lung	NCIH1975	5.8
Lung	NCIH2009	6.2
Lung	NCIH2023	6.1
Lung	NCIH2029	5.7
Lung	NCIH2030	5.9
Lung	NCIH2066	5.6
Lung	NCIH2081	5.7
Lung	NCIH2085	5.5
Lung	NCIH2087	5.9
Lung	NCIH209	6.2
Lung	NCIH2106	5.6
Lung	NCIH2110	5.7
Lung	NCIH211	5.8
Lung	NCIH2122	6.4
Lung	NCIH2126	6.1
Lung	NCIH2141	5.7
Lung	NCIH2170	6.3
Lung	NCIH2171	6.2
Lung	NCIH2172	5.9
Lung	NCIH2196	6.5
Lung	NCIH2227	6.7
Lung	NCIH2228	5.7
Lung	NCIH226	5.6
Lung	NCIH2286	5.8
Lung	NCIH2291	5.9
Lung	NCIH2342	5.9
Lung	NCIH2347	5.7
Lung	NCIH23	6
Lung	NCIH2405	5.7
Lung	NCIH2444	5.7
Lung	NCIH292	5.6
Lung	NCIH322	6.1
Lung	NCIH3255	6.4
Lung	NCIH358	6.4
Lung	NCIH441	5.8
Lung	NCIH446	6.8
Lung	NCIH460	5.9
Lung	NCIH510	5.9
Lung	NCIH520	6.2
Lung	NCIH522	6.2
Lung	NCIH524	6.6
Lung	NCIH526	6.5
Lung	NCIH596	5.4
Lung	NCIH647	5.5
Lung	NCIH650	5.6
Lung	NCIH661	6.1
Lung	NCIH69	6
Lung	NCIH727	5.7
Lung	NCIH810	6
Lung	NCIH82	6.1
Lung	NCIH838	6.3
Lung	NCIH841	6.4
Lung	NCIH854	6.7
Lung	NCIH889	6.3
Lung	PC14	5.9
Lung	RERFLCAD1	5.4
Lung	RERFLCAD2	6
Lung	RERFLCAI	5.8
Lung	RERFLCKJ	5.9
Lung	RERFLCMS	6
Lung	RERFLCSQ1	5.8
Lung	SBC5	6.8
Lung	SCLC21H	6.2
Lung	SHP77	5.7
Lung	SKLU1	5.7
Lung	SKMES1	5.7
Lung	SQ1	5.9
Lung	SW1271	5.8
Lung	SW1573	5.6
Lung	SW900	6.4
Lung	VMRCLCD	6.4
Lung	VMRCLCP	5.7
Oesophagus	COLO680N	5.5
Oesophagus	ECGI10	5.5
Oesophagus	KYSE140	5.7
Oesophagus	KYSE150	6.2
Oesophagus	KYSE180	6
Oesophagus	KYSE270	6.2
Oesophagus	KYSE30	5.9
Oesophagus	KYSE410	5.3
Oesophagus	KYSE450	5.8
Oesophagus	KYSE510	5.8
Oesophagus	KYSE520	5.7
Oesophagus	KYSE70	5.8
Oesophagus	OE19	6.8
Oesophagus	OE33	5.6
Oesophagus	TE10	5.7
Oesophagus	TE11	5.7
Oesophagus	TE14	5.2
Oesophagus	TE15	6.5
Oesophagus	TE1	5.6
Oesophagus	TE4	5.7
Oesophagus	TE5	5.5
Oesophagus	TE6	5.7
Oesophagus	TE8	5.6
Oesophagus	TE9	6.3
Oesophagus	TT	6.1
Ovary	59M	6.2
Ovary	A2780	7.3
Ovary	CAOV3	5.7
Ovary	CAOV4	5.6
Ovary	COLO704	6.3
Ovary	COV318	5.7
Ovary	COV362	5.7
Ovary	COV434	6.7
Ovary	COV504	5.2
Ovary	COV644	5.8
Ovary	EFO21	7
Ovary	EFO27	5.7
Ovary	ES2	5.4
Ovary	FUOV1	5.8
Ovary	HEYA8	5.7
Ovary	HS571T	5.5
Ovary	IGROV1	6.6
Ovary	JHOC5	5.3
Ovary	JHOM1	5.5
Ovary	JHOM2B	5.9
Ovary	JHOS2	5.7
Ovary	JHOS4	6
Ovary	KURAMOCHI	5.9
Ovary	MCAS	6.3
Ovary	NIHOVCAR3	5.7
Ovary	OAW28	6
Ovary	OAW42	6.4
Ovary	OC314	5.2
Ovary	OC316	5.7
Ovary	ONCODG1	5.6
Ovary	OV56	5.5
Ovary	OV7	5.8
Ovary	OV90	5.9
Ovary	OVCAR4	6.4
Ovary	OVCAR8	5.9
Ovary	OVISE	5.5
Ovary	OVK18	6.7
Ovary	OVKATE	6
Ovary	OVMANA	6.2
Ovary	OVSAHO	6.9
Ovary	OVTOKO	5.7
Ovary	RMGI	6.2
Ovary	RMUGS	5.6
Ovary	SKOV3	5.6
Ovary	SNU119	4.7
Ovary	SNU840	5.8
Ovary	SNU8	5.6
Ovary	TOV112D	6.8
Ovary	TOV21G	5.7
Ovary	TYKNU	5.9
Pancreas	ASPC1	5.9
Pancreas	BXPC3	5.7
Pancreas	CAPAN1	5.7
Pancreas	CAPAN2	5.4
Pancreas	CFPAC1	5.4
Pancreas	DANG	5.2
Pancreas	HPAC	5.9
Pancreas	HPAFII	5.5
Pancreas	HS766T	5.8
Pancreas	HUPT3	5.7
Pancreas	HUPT4	5.7
Pancreas	KCIMOH1	6.3
Pancreas	KLM1	7
Pancreas	KP2	6.1
Pancreas	KP3	5.5
Pancreas	KP4	5.9
Pancreas	L33	5.8
Pancreas	MIAPACA2	5.6
Pancreas	PANC0203	5.6
Pancreas	PANC0213	5.7
Pancreas	PANC0327	5.6
Pancreas	PANC0403	5.3
Pancreas	PANC0504	5.4
Pancreas	PANC0813	5.5
Pancreas	PANC1005	5.9
Pancreas	PANC1	6.1
Pancreas	PATU8902	6.2
Pancreas	PATU8988S	5.4
Pancreas	PATU8988T	5.9
Pancreas	PK1	5.9
Pancreas	PK45H	5.7
Pancreas	PK59	5.4
Pancreas	PL45	5.8
Pancreas	PSN1	6.3
Pancreas	QGP1	5.9
Pancreas	SNU213	5.7
Pancreas	SNU324	6
Pancreas	SNU410	5.6
Pancreas	SU8686	5.3
Pancreas	SUIT2	5.7
Pancreas	SW1990	5.9
Pancreas	T3M4	6.8
Pancreas	TCCPAN2	6
Pancreas	YAPC	5.9
Pleura	ACCMESO1	6.1
Pleura	DM3	5.7
Pleura	ISTMES1	5.2
Pleura	ISTMES2	5.7
Pleura	JL1	5.6
Pleura	MPP89	6
Pleura	MSTO211H	5.7
Pleura	NCIH2052	5.9
Pleura	NCIH2452	5.6
Pleura	NCIH28	5.9
Prostate	22RV1	6
Prostate	DU145	5.9
Prostate	LNCAPCLONEFGC	5.8
Prostate	MDAPCA2B	6.2
Prostate	NCIH660	6
Prostate	PC3	6.1
Prostate	VCAP	5.7
Salivary gland	A253	5.7
Salivary gland	YD15	6.2
Skin	A101D	5.9
Skin	A2058	7
Skin	A375	6.2
Skin	C32	5.6
Skin	CHL1	5.6
Skin	CJM	6.6
Skin	COLO679	6.5
Skin	COLO741	5.6
Skin	COLO783	5.7
Skin	COLO792	6
Skin	COLO800	6.1
Skin	COLO818	5.8
Skin	COLO829	6.5
Skin	COLO849	6.9
Skin	G361	6.1
Skin	GRM	6.5
Skin	HMCB	6.1
Skin	HS294T	6.3
Skin	HS600T	5.4
Skin	HS688AT	5.7
Skin	HS695T	6
Skin	HS839T	5.4
Skin	HS852T	5.6
Skin	HS895T	5.8
Skin	HS934T	5.6
Skin	HS936T	6.1
Skin	HS939T	6.2
Skin	HS940T	5.7
Skin	HS944T	6.7
Skin	HT144	5.8
Skin	IGR1	6
Skin	IGR37	6.7
Skin	IGR39	5.8
Skin	IPC298	5.8
Skin	K029AX	6
Skin	LOXIMVI	6
Skin	MALME3M	6.1
Skin	MDAMB435S	5.7
Skin	MELHO	6
Skin	MELJUSO	6.1
Skin	MEWO	6.3
Skin	RPMI7951	5.3
Skin	RVH421	6
Skin	SH4	6.1
Skin	SKMEL1	5.8
Skin	SKMEL24	5.9
Skin	SKMEL28	5.8
Skin	SKMEL2	6.1
Skin	SKMEL30	6
Skin	SKMEL31	5.7
Skin	SKMEL3	6.9
Skin	SKMEL5	6.7
Skin	UACC257	6.6
Skin	UACC62	5.9
Skin	WM115	5.6
Skin	WM1799	6.4
Skin	WM2664	5.6
Skin	WM793	5.6
Skin	WM88	5.7
Skin	WM983B	5.8
Small intestine	HUTU80	5.9
Soft tissue	A204	6.1
Soft tissue	G401	6.3
Soft tissue	G402	6.6
Soft tissue	GCT	5.8
Soft tissue	HS729	5.5
Soft tissue	HT1080	6.1
Soft tissue	KYM1	6.5
Soft tissue	MESSA	7.1
Soft tissue	RD	5.6
Soft tissue	RH30	6.3
Soft tissue	RH41	6.1
Soft tissue	RKN	5.4
Soft tissue	S117	5.4
Soft tissue	SJRH30	5.7
Soft tissue	SKLMS1	6.3
Soft tissue	SKUT1	5.8
Soft tissue	TE125T	5.6
Soft tissue	TE159T	5.7
Soft tissue	TE441T	5.8
Soft tissue	TE617T	6.3
Stomach	2313287	6.4
Stomach	AGS	5.9
Stomach	AZ521	6
Stomach	ECC10	6.1
Stomach	ECC12	5.8
Stomach	FU97	6.6
Stomach	GCIY	5.6
Stomach	GSS	6.1
Stomach	GSU	6.3
Stomach	HGC27	6.2
Stomach	HS746T	6.2
Stomach	HUG1N	5.9
Stomach	IM95	7
Stomach	KATOIII	6.3
Stomach	KE39	5.7
Stomach	LMSU	5.6
Stomach	MKN1	5.4
Stomach	MKN45	5.8
Stomach	MKN74	5.8
Stomach	MKN7	5.7
Stomach	NCCSTCK140	7.6
Stomach	NCIN87	5.9
Stomach	NUGC2	5.9
Stomach	NUGC3	5.8
Stomach	NUGC4	6.3
Stomach	OCUM1	6.4
Stomach	RERFGC1B	6
Stomach	SH10TC	5.6
Stomach	SNU16	6
Stomach	SNU1	5.8
Stomach	SNU216	5.7
Stomach	SNU520	6
Stomach	SNU5	6.2
Stomach	SNU601	6.3
Stomach	SNU620	5.5
Stomach	SNU668	7.1
Stomach	SNU719	6.4
Stomach	TGBC11TKB	6.2
Thyroid	8305C	5.4
Thyroid	8505C	5.6
Thyroid	BCPAP	5.7
Thyroid	BHT101	5.7
Thyroid	CAL62	5.7
Thyroid	CGTHW1	5.5
Thyroid	FTC133	5.3
Thyroid	FTC238	5.8
Thyroid	ML1	5.7
Thyroid	SW579	5.8
Thyroid	TT2609C02	5.5
Thyroid	TT	5.7
Upper aerodigestive tract	BHY	5.1
Upper aerodigestive tract	BICR16	5.8
Upper aerodigestive tract	BICR18	5.8
Upper aerodigestive tract	BICR22	5.5
Upper aerodigestive tract	BICR31	6
Upper aerodigestive tract	BICR56	5.6
Upper aerodigestive tract	BICR6	5.8
Upper aerodigestive tract	CAL27	5.5
Upper aerodigestive tract	CAL33	5.4
Upper aerodigestive tract	DETROIT562	5.7
Upper aerodigestive tract	FADU	6.6
Upper aerodigestive tract	HS840T	5.7
Upper aerodigestive tract	HSC2	5.7
Upper aerodigestive tract	HSC3	5.5
Upper aerodigestive tract	HSC4	5.7
Upper aerodigestive tract	PECAPJ15	5.1
Upper aerodigestive tract	PECAPJ34CLONEC12	5.7
Upper aerodigestive tract	PECAPJ41CLONED2	5.9
Upper aerodigestive tract	PECAPJ49	5.3
Upper aerodigestive tract	SCC15	5.5
Upper aerodigestive tract	SCC25	5.8
Upper aerodigestive tract	SCC4	5.8
Upper aerodigestive tract	SCC9	5.9
Upper aerodigestive tract	SNU1076	5.7
Upper aerodigestive tract	SNU1214	5.8
Upper aerodigestive tract	SNU46	6.3
Upper aerodigestive tract	SNU899	5.8
Upper aerodigestive tract	YD10B	5.4
Upper aerodigestive tract	YD38	5.7
Upper aerodigestive tract	YD8	5.7
Urinary tract	5637	6.1
Urinary tract	639V	5.9
Urinary tract	647V	5.8
Urinary tract	BC3C	5.5
Urinary tract	BFTC905	5.6
Urinary tract	CAL29	5.6
Urinary tract	HS172T	5.7
Urinary tract	HT1197	6.1
Urinary tract	HT1376	5.5
Urinary tract	J82	5.5
Urinary tract	JMSU1	5.7
Urinary tract	KMBC2	5.1
Urinary tract	KU1919	5.2
Urinary tract	RT11284	5.6
Urinary tract	RT112	5.8
Urinary tract	RT4	5.3
Urinary tract	SCABER	5.9
Urinary tract	SW1710	5.6
Urinary tract	SW780	5.6
Urinary tract	T24	5.9
Urinary tract	TCCSUP	6.9
Urinary tract	UMUC1	5.8
Urinary tract	UMUC3	5.7
Urinary tract	VMCUB1	5.5

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	1.8
Adrenal gland	2.3
Appendix	3.5
Bone marrow	1.4
Breast	1.4
Cerebral cortex	5.5
Cervix, uterine	1.7
Colon	1.7
Duodenum	3
Endometrium	2.5
Epididymis	13.5
Esophagus	1.2
Fallopian tube	4.7
Gallbladder	2.9
Heart muscle	1.2
Kidney	1.7
Liver	0.7
Lung	2.7
Lymph node	3.5
Ovary	1.3
Pancreas	0.3
Parathyroid gland	8.2
Placenta	3.6
Prostate	2.6
Rectum	0.9
Salivary gland	1.1
Seminal vesicle	2.8
Skeletal muscle	0.8
Skin	2.7
Small intestine	2.5
Smooth muscle	1.5
Spleen	2.4
Stomach	2.8
Testis	8.3
Thyroid gland	3.3
Tonsil	1.9
Urinary bladder	1.6

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
27346354	overexpression	Breast Carcinoma	Accordingly, Cbx8 is overexpressed in human breast cancer andcorrelates with poor survival.
25360999	aberrant expression	Colorectal Carcinoma	Here, we found that high CBX8 expression was associated with a low rate of distant metastasis and good prognosis in CRC patients, even though CBX8 was up-regulated in CRC cell lines and clinical samples.
25197352	overexpression	Esophageal Squamous Cell Carcinoma	In this study, we found that CBX8 was up-regulated in esophageal carcinoma tissues compared with adjacent non-cancerous tissues (P<0.01) and correlated with TNM stage in esophageal squamous cell carcinoma patients.
24260522	aberrant expression	Glioblastoma	The most striking differences were upregulation of EZH2, PHF19, CBX8 and PHC2 and downregulation of CBX7, CBX6, EZH1 and RYBP.
26693053	overexpression	Hepatocellular Carcinoma	Furthermore, Immunohistochemical staining revealed that the expression levels of CBX8 (in 53/123 samples) and BMI1 (in 60/130 samples) were markedly increased in human HCC specimens.
28161066	overexpression	Gestational Choriocarcinoma	Gains of CBX2, CBX4 and CBX8 were frequently found in high risk prognostic score in GC.

Summary
Symbol	CBX8
Name	chromobox 8
Aliases	RC1; HPC3; polycomb 3; Pc class 3 homolog (Drosophila); chromobox homolog 8 (Drosophila Pc class); Pc class ......
Location	17q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.339	2.39e-12	4.7	47.8	47.5	Gain
BRCA	Breast invasive carcinoma	1075	0.419	5.05e-47	14.9	47.5	37.6	Gain
CESC	Cervical and endocervical cancers	292	0.36	2.43e-10	14.4	63	22.6	Neutral
COAD	Colon adenocarcinoma	449	0.353	1.2e-14	12	63.9	24.1	Neutral
ESCA	Esophageal carcinoma	183	0.338	2.8e-06	17.5	49.7	32.8	Neutral
GBM	Glioblastoma multiforme	147	0.162	0.0503	12.2	74.8	12.9	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.351	2.58e-16	9.9	69.1	21	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.052	0.238	5.1	86.7	8.2	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.236	5.39e-05	0.3	30.2	69.4	Gain
LAML	Acute Myeloid Leukemia	166	0.097	0.216	3	94.6	2.4	Neutral
LGG	Brain Lower Grade Glioma	513	0.249	1.16e-08	2.3	88.9	8.8	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.457	3.19e-20	6.3	55.8	37.9	Gain
LUAD	Lung adenocarcinoma	512	0.324	5.92e-14	5.5	42.8	51.8	Gain
LUSC	Lung squamous cell carcinoma	498	0.448	5.42e-26	14.9	40.8	44.4	Gain
OV	Ovarian serous cystadenocarcinoma	300	0.467	1.21e-17	32.7	29.3	38	Gain
PAAD	Pancreatic adenocarcinoma	177	0.379	2.02e-07	20.3	67.2	12.4	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.211	0.00712	8	85.2	6.8	Neutral
PRAD	Prostate adenocarcinoma	491	0.23	2.49e-07	5.9	90.4	3.7	Neutral
READ	Rectum adenocarcinoma	164	0.422	1.84e-08	14	64.6	21.3	Neutral
SARC	Sarcoma	255	0.174	0.00533	19.6	52.9	27.5	Neutral
SKCM	Skin Cutaneous Melanoma	367	0.354	2.65e-12	12	54.2	33.8	Gain
STAD	Stomach adenocarcinoma	413	0.238	9.98e-07	17.7	62.5	19.9	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.105	0.203	6.7	54.7	38.7	Gain
THCA	Thyroid carcinoma	497	0.197	9.52e-06	0.2	95.6	4.2	Neutral
THYM	Thymoma	119	-0.061	0.509	3.4	88.2	8.4	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.306	3.88e-13	9.7	72.8	17.5	Neutral

Summary
Symbol	CBX8
Name	chromobox 8
Aliases	RC1; HPC3; polycomb 3; Pc class 3 homolog (Drosophila); chromobox homolog 8 (Drosophila Pc class); Pc class ......
Location	17q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.129	0.00771	17	408	-0.003	0.00336	NS/NA
BRCA	Breast invasive carcinoma	-0.177	1.68e-07	83	785	-0.004	0.00893	NS/NA
CESC	Cervical and endocervical cancers	-0.116	0.0421	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.118	0.0369	19	297	0.001	0.0536	NS/NA
ESCA	Esophageal carcinoma	-0.215	0.00271	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.036	0.778	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.073	0.0885	20	522	0.002	0.48	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.262	9.72e-07	24	319	0.005	0.0975	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.25	1.33e-05	23	275	-0.004	0.0132	NS/NA
LAML	Acute Myeloid Leukemia	-0.036	0.64	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.069	0.113	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.224	4.37e-06	41	373	-0.005	0.589	NS/NA
LUAD	Lung adenocarcinoma	-0.15	0.000993	21	456	-0.012	0.0993	NS/NA
LUSC	Lung squamous cell carcinoma	-0.019	0.717	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.25	0.521	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.254	0.000536	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.123	0.0928	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.167	0.000109	35	498	-0.006	0.00833	NS/NA
READ	Rectum adenocarcinoma	-0.134	0.181	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.09	0.144	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.159	0.000521	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.136	0.0087	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.228	0.00434	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.082	0.0517	50	509	-0.002	0.336	NS/NA
THYM	Thymoma	-0.1	0.275	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.062	0.181	34	431	-0.001	0.291	NS/NA

Summary
Symbol	CBX8
Name	chromobox 8
Aliases	RC1; HPC3; polycomb 3; Pc class 3 homolog (Drosophila); chromobox homolog 8 (Drosophila Pc class); Pc class ......
Location	17q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	2	Medium
Appendix	1	Low
Bone marrow	3	High
Breast	2	Medium
Bronchus	3	High
Caudate	1	Low
Cerebellum	2	Medium
Cerebral cortex	1	Low
Cervix, uterine	2	Medium
Colon	3	High
Duodenum	2	Medium
Endometrium	2	Medium
Epididymis	2	Medium
Esophagus	2	Medium
Fallopian tube	3	High
Gallbladder	2	Medium
Heart muscle	2	Medium
Hippocampus	0	Not detected
Kidney	2	Medium
Liver	0	Not detected
Lung	1	Low
Lymph node	1	Low
Nasopharynx	3	High
Oral mucosa	1	Low
Ovary	0	Not detected
Pancreas	2	Medium
Parathyroid gland	0	Not detected
Placenta	2	Medium
Prostate	2	Medium
Rectum	3	High
Salivary gland	2	Medium
Seminal vesicle	2	Medium
Skeletal muscle	2	Medium
Skin	3	High
Small intestine	1	Low
Smooth muscle	2	Medium
Soft tissue	2	Medium
Spleen	2	Medium
Stomach	2	Medium
Testis	3	High
Thyroid gland	2	Medium
Tonsil	1	Low
Urinary bladder	2	Medium
Vagina	3	High

Summary
Symbol	CBX8
Name	chromobox 8
Aliases	RC1; HPC3; polycomb 3; Pc class 3 homolog (Drosophila); chromobox homolog 8 (Drosophila Pc class); Pc class ......
Location	17q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.537	NS	24476821
BRCA	Breast invasive carcinoma	521	8.61e-13	Significant	23000897
COAD	Colon adenocarcinoma	149	0.000543	Significant	22810696
GBM	Glioblastoma multiforme	157	0.00178	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	5.34e-07	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.869	NS	26536169
LGG	Brain Lower Grade Glioma	513	0.00881	Significant	26824661
LUAD	Lung adenocarcinoma	230	0.0105	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	1.34e-06	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	2.68e-10	Significant	21720365
PRAD	Prostate adenocarcinoma	333	7.72e-06	Significant	26544944
READ	Rectum adenocarcinoma	67	0.407	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.879	NS	26091043
STAD	Stomach adenocarcinoma	277	3.81e-05	Significant	25079317
THCA	Thyroid carcinoma	391	5.58e-20	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.0165	Significant	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	0.832	0.387	NS
BRCA	Breast invasive carcinoma	1079	1.186	0.452	NS
CESC	Cervical and endocervical cancers	291	1.273	0.504	NS
COAD	Colon adenocarcinoma	439	1.006	0.985	NS
ESCA	Esophageal carcinoma	184	1.296	0.415	NS
GBM	Glioblastoma multiforme	158	0.796	0.378	NS
HNSC	Head and Neck squamous cell carcinoma	518	0.935	0.724	NS
KIRC	Kidney renal clear cell carcinoma	531	2.747	1.4e-06	Shorter
KIRP	Kidney renal papillary cell carcinoma	287	1.156	0.74	NS
LAML	Acute Myeloid Leukemia	149	0.962	0.894	NS
LGG	Brain Lower Grade Glioma	511	2.222	0.000929	Shorter
LIHC	Liver hepatocellular carcinoma	365	1.45	0.119	NS
LUAD	Lung adenocarcinoma	502	0.886	0.577	NS
LUSC	Lung squamous cell carcinoma	494	0.973	0.89	NS
OV	Ovarian serous cystadenocarcinoma	303	0.573	0.00829	Longer
PAAD	Pancreatic adenocarcinoma	177	0.347	0.000554	Longer
PCPG	Pheochromocytoma and Paraganglioma	179	4.432	0.139	NS
PRAD	Prostate adenocarcinoma	497	1.551	0.564	NS
READ	Rectum adenocarcinoma	159	0.923	0.872	NS
SARC	Sarcoma	259	1.125	0.659	NS
SKCM	Skin Cutaneous Melanoma	459	1.176	0.406	NS
STAD	Stomach adenocarcinoma	388	0.639	0.0457	Longer
TGCT	Testicular Germ Cell Tumors	134	0.455	0.51	NS
THCA	Thyroid carcinoma	500	1.336	0.667	NS
THYM	Thymoma	119	0.214	0.124	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	0.864	0.626	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	-0.001	0.982	NS
BRCA	Breast invasive carcinoma	1071	0.058	0.0596	NS
CESC	Cervical and endocervical cancers	167	0.247	0.00129	Higher
COAD	Colon adenocarcinoma	445	0.119	0.0119	Higher
ESCA	Esophageal carcinoma	162	-0.006	0.942	NS
HNSC	Head and Neck squamous cell carcinoma	448	0.094	0.0459	Higher
KIRC	Kidney renal clear cell carcinoma	531	0.165	0.000137	Higher
KIRP	Kidney renal papillary cell carcinoma	260	0.093	0.134	NS
LIHC	Liver hepatocellular carcinoma	347	0.06	0.266	NS
LUAD	Lung adenocarcinoma	507	0.038	0.398	NS
LUSC	Lung squamous cell carcinoma	497	0.018	0.682	NS
OV	Ovarian serous cystadenocarcinoma	302	-0.177	0.00206	Lower
PAAD	Pancreatic adenocarcinoma	176	-0.009	0.904	NS
READ	Rectum adenocarcinoma	156	0.107	0.183	NS
SKCM	Skin Cutaneous Melanoma	410	-0.028	0.578	NS
STAD	Stomach adenocarcinoma	392	-0.079	0.117	NS
TGCT	Testicular Germ Cell Tumors	81	-0.089	0.431	NS
THCA	Thyroid carcinoma	499	0.016	0.715	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.014	0.748	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	0.028	0.643	NS
HNSC	Head and Neck squamous cell carcinoma	498	0.077	0.0867	NS
KIRC	Kidney renal clear cell carcinoma	525	0.203	2.81e-06	Higher
LGG	Brain Lower Grade Glioma	514	0.237	5.21e-08	Higher
LIHC	Liver hepatocellular carcinoma	366	0.135	0.0098	Higher
OV	Ovarian serous cystadenocarcinoma	296	0.002	0.973	NS
PAAD	Pancreatic adenocarcinoma	176	-0.045	0.554	NS
STAD	Stomach adenocarcinoma	406	-0.118	0.017	Lower
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.115	0.00777	Higher

Summary
Symbol	CBX8
Name	chromobox 8
Aliases	RC1; HPC3; polycomb 3; Pc class 3 homolog (Drosophila); chromobox homolog 8 (Drosophila Pc class); Pc class ......
Location	17q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	CBX8
Name	chromobox 8
Aliases	RC1; HPC3; polycomb 3; Pc class 3 homolog (Drosophila); chromobox homolog 8 (Drosophila Pc class); Pc class ......
Location	17q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

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There is no record for CBX8.

Summary
Symbol	CBX8
Name	chromobox 8
Aliases	RC1; HPC3; polycomb 3; Pc class 3 homolog (Drosophila); chromobox homolog 8 (Drosophila Pc class); Pc class ......
Location	17q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

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PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
27346354	Breast Carcinoma	downstream	Notch signaling	positive regulation	Our genomic analyses revealed that Cbx8 positively regulates Notch signaling by maintaining H3K4me3 levels on Notch-network gene promoters.
25360999	Colorectal Carcinoma	downstream	p53; ITGB4; RhoA	negative regulation; negative regulation; positive regulation	Knockdown of CBX8 inhibited CRC proliferation in vitro and in vivo, mostly by increasing p53 and its downstream effectors. However, knockdown of CBX8 enhanced CRC migration, invasion and metastasis in vitro and in vivo, in part through direct up-regulation of integrin β4 (ITGB4) that in turn decreased RhoA activity.
25197352	Esophageal Squamous Cell Carcinoma	downstream	CDK	positive regulation	Depletion of CBX8 decreased cell proliferation both in vitro and in vivo and increased the phosphorylation levels of p21, Wee1, and CHK1, which result in cyclin-dependent kinase inhibition and cell-cycle delay.