Browse DPF3 in pancancer

Summary
SymbolDPF3
Namedouble PHD fingers 3
Aliases cer-d4; Cerd4; FLJ14079; BAF45c; BRG1-associated factor 45C; zinc finger protein cer-d4; Zinc finger protein ......
Location14q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Domain, Function and Classification
> Gene Ontology
> KEGG and Reactome Pathway
> Domain, Function and Classification
 
Domain PF00628 PHD-finger
PF14051 N-terminal domain of DPF2/REQ.
Function

Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Muscle-specific component of the BAF complex, a multiprotein complex involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Specifically binds acetylated lysines on histone 3 and 4 (H3K14ac, H3K9ac, H4K5ac, H4K8ac, H4K12ac, H4K16ac). In the complex, it acts as a tissue-specific anchor between histone acetylations and methylations and chromatin remodeling. It thereby probably plays an essential role in heart and skeletal muscle development.

Classification
Class Modification Substrate Product PubMed
Chromatin remodelling # H3, H4 # 21423274
> Gene Ontology
 
Biological Process -
Molecular Function -
Cellular Component GO:0070603 SWI/SNF superfamily-type complex
GO:0071565 nBAF complex
GO:0090544 BAF-type complex
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolDPF3
Namedouble PHD fingers 3
Aliases cer-d4; Cerd4; FLJ14079; BAF45c; BRG1-associated factor 45C; zinc finger protein cer-d4; Zinc finger protein ......
Location14q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Mutation landscape in primary tumor tissue from TCGA
> Mutation landscape in cancer cell line from CCLE
> All mutations from COSMIC database V81
> Variations from text mining
> The Cancer Genome Atlas (TCGA)
 
> Cancer Cell Line Encyclopedia (CCLE)
 
There is no record.
> Catalogue of Somatic Mutations in Cancer (COSMIC)
 
There is no record for DPF3.
> Text Mining based Variations
 
PMID Variation Cancer Evidence
16109180MutationBreast CarcinomaPolymorphisms in the 5' region of DPF3 were associated with increased risk of breast cancer development, lymph node metastases, age of onset, and tumor size in women of European ancestry.
Summary
SymbolDPF3
Namedouble PHD fingers 3
Aliases cer-d4; Cerd4; FLJ14079; BAF45c; BRG1-associated factor 45C; zinc finger protein cer-d4; Zinc finger protein ......
Location14q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Post-translational modification (PTM)
> Post-translational modification (PTM)
 
There is no PTM data
Summary
SymbolDPF3
Namedouble PHD fingers 3
Aliases cer-d4; Cerd4; FLJ14079; BAF45c; BRG1-associated factor 45C; zinc finger protein cer-d4; Zinc finger protein ......
Location14q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Expression analysis in primary tumor tissue from TCGA
> Expression level in cancer cell line from CCLE
> Expression level in human normal tissue from HPA
> Text mining based expression change
> The Cancer Genome Atlas (TCGA)
 


  Differential expression analysis for cancers with more than 10 normal samples
Cancer Full Name # N # T Median (N) Median (T) LogFC Adj. P Status
BLCABladder urothelial carcinoma19408-0.203-2.041-1.6416.3e-05Under
BRCABreast invasive carcinoma11211000.093-1.467-1.595.97e-22Under
CESCCervical and endocervical cancers3306-2.419-1.322NANANA
COADColon adenocarcinoma414592.714-0.448-3.0823.41e-32Under
ESCAEsophageal carcinoma111850.111-2.07-1.940.00062Under
GBMGlioblastoma multiforme51662.7713.884NANANA
HNSCHead and Neck squamous cell carcinoma44522-0.35-1.163-1.2151.38e-06Under
KIRCKidney renal clear cell carcinoma725341.2681.9970.5810.00443Over
KIRPKidney renal papillary cell carcinoma322912.1650.224-1.4874.2e-06Under
LAMLAcute Myeloid Leukemia0173NA-1.185NANANA
LGGBrain Lower Grade Glioma0530NA3.474NANANA
LIHCLiver hepatocellular carcinoma503731.507-1.043-2.5773.54e-20Under
LUADLung adenocarcinoma59517-1.113-1.222-0.2650.142NS
LUSCLung squamous cell carcinoma51501-0.963-1.883-0.9964.04e-08Under
OVOvarian serous cystadenocarcinoma0307NA1.089NANANA
PAADPancreatic adenocarcinoma4179-0.098-0.748NANANA
PCPGPheochromocytoma and Paraganglioma31841.6171.698NANANA
READRectum adenocarcinoma101672.323-0.46-2.8291.64e-08Under
SARCSarcoma22631.560.139NANANA
SKCMSkin Cutaneous Melanoma14720.681-0.292NANANA
STADStomach adenocarcinoma354150.243-0.902-0.910.00026Under
TGCTTesticular Germ Cell Tumors0156NA0.174NANANA
THCAThyroid carcinoma59509-0.748-0.6810.090.516NS
THYMThymoma21200.339-0.384NANANA
UCECUterine Corpus Endometrial Carcinoma35546-0.938-1.667-0.9030.00176Under
> Cancer Cell Line Encyclopedia (CCLE)
 

There is no record.
> The Human Protein Atlas (HPA)
 


Tissue Expression Level (TPM)
Adipose tissue 0.1
Adrenal gland 1.8
Appendix 0.7
Bone marrow 1.6
Breast 0.3
Cerebral cortex 7.4
Cervix, uterine 0.6
Colon 1.9
Duodenum 0.2
Endometrium 0.4
Epididymis 0.2
Esophagus 0.6
Fallopian tube 0.3
Gallbladder 0.4
Heart muscle 8.8
Kidney 1.5
Liver 1.6
Lung 0.4
Lymph node 1
Ovary 16.7
Pancreas 0
Parathyroid gland 10.1
Placenta 0.5
Prostate 0.2
Rectum 1.6
Salivary gland 0
Seminal vesicle 0.2
Skeletal muscle 9.1
Skin 0.5
Small intestine 1.1
Smooth muscle 0.8
Spleen 1
Stomach 0.4
Testis 3.1
Thyroid gland 0.3
Tonsil 1
Urinary bladder 0.2
> Text Mining based Expression
 
There is no record.
Summary
SymbolDPF3
Namedouble PHD fingers 3
Aliases cer-d4; Cerd4; FLJ14079; BAF45c; BRG1-associated factor 45C; zinc finger protein cer-d4; Zinc finger protein ......
Location14q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Somatic copy number alteration in primary tomur tissue
> The Cancer Genome Atlas (TCGA)
 


  Correlation between expression and SCNA as well as percentage of patients in different status.
Cancer Full Name # Sample R P % Loss % Neutral % Gain Status
BLCABladder urothelial carcinoma4040.1790.00029231.951.516.6Neutral
BRCABreast invasive carcinoma10750.0980.001283355.311.7Neutral
CESCCervical and endocervical cancers2920.0250.67613.468.518.2Neutral
COADColon adenocarcinoma4490.2471.16e-0733.259.57.3Neutral
ESCAEsophageal carcinoma1830.1720.020127.944.827.3Neutral
GBMGlioblastoma multiforme1470.4141.92e-0737.457.15.4Loss
HNSCHead and Neck squamous cell carcinoma5140.1230.0050911.557.630.9Neutral
KIRCKidney renal clear cell carcinoma5250.2515.17e-0943.253.73Loss
KIRPKidney renal papillary cell carcinoma2880.190.001217.481.90.7Neutral
LAMLAcute Myeloid Leukemia1660.0930.235098.81.2Neutral
LGGBrain Lower Grade Glioma5130.4418.06e-2623.475.80.8Neutral
LIHCLiver hepatocellular carcinoma3640.4122.59e-1634.959.16Loss
LUADLung adenocarcinoma5120.1832.97e-0527.34923.6Neutral
LUSCLung squamous cell carcinoma4980.0970.030536.53825.5Loss
OVOvarian serous cystadenocarcinoma3000.2529.67e-0648.73813.3Loss
PAADPancreatic adenocarcinoma1770.1410.060810.27415.8Neutral
PCPGPheochromocytoma and Paraganglioma1620.3641.88e-0614.882.13.1Neutral
READRectum adenocarcinoma1640.160.040141.552.46.1Loss
SARCSarcoma2550.3794.02e-1031.446.722Neutral
SKCMSkin Cutaneous Melanoma3670.170.001063356.110.9Neutral
STADStomach adenocarcinoma4130.2244.15e-0629.363.96.8Neutral
TGCTTesticular Germ Cell Tumors1500.4151.28e-07145036Gain
THCAThyroid carcinoma4970.1110.01290.497.42.2Neutral
THYMThymoma119-0.0210.8192.586.610.9Neutral
UCECUterine Corpus Endometrial Carcinoma537-0.0150.73213.478.48.2Neutral
Summary
SymbolDPF3
Namedouble PHD fingers 3
Aliases cer-d4; Cerd4; FLJ14079; BAF45c; BRG1-associated factor 45C; zinc finger protein cer-d4; Zinc finger protein ......
Location14q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Methylation level in the promoter region of CR
> Methylation level in the promoter region of CR
 


  Correlation between expression and methylation as well as differential methylation analysis.
Cancer Full Name R P # N # T Delta beta (T vs N) P value (T vs N) Status
BLCABladder urothelial carcinoma-0.0920.057917408-0.0010.0413NS/NA
BRCABreast invasive carcinoma-0.214.94e-10837850.0052.13e-27NS/NA
CESCCervical and endocervical cancers-0.210.0002083306NANANS/NA
COADColon adenocarcinoma-0.1310.0199192970.0024.01e-05NS/NA
ESCAEsophageal carcinoma-0.1490.03829185NANANS/NA
GBMGlioblastoma multiforme-0.4699.67e-05164NANANS/NA
HNSCHead and Neck squamous cell carcinoma-0.0920.0316205220.0085.76e-05NS/NA
KIRCKidney renal clear cell carcinoma-0.1410.00911243190.0080.956NS/NA
KIRPKidney renal papillary cell carcinoma-0.1650.0043232750.0133.92e-07NS/NA
LAMLAcute Myeloid Leukemia-0.240.001630170NANANS/NA
LGGBrain Lower Grade Glioma-0.2052.01e-060530NANANS/NA
LIHCLiver hepatocellular carcinoma-0.2835.35e-09413730.0055.51e-12NS/NA
LUADLung adenocarcinoma-0.10.0293214560.0070.0631NS/NA
LUSCLung squamous cell carcinoma-0.1020.04788370NANANS/NA
OVOvarian serous cystadenocarcinoma-0.50.17809NANANS/NA
PAADPancreatic adenocarcinoma-0.2280.001934179NANANS/NA
PCPGPheochromocytoma and Paraganglioma-0.3199.49e-063184NANANS/NA
READRectum adenocarcinoma-0.2560.00979299NANANS/NA
SARCSarcoma-0.2892.07e-060263NANANS/NA
SKCMSkin Cutaneous Melanoma-0.1410.002221471NANANS/NA
STADStomach adenocarcinoma-0.0440.4010372NANANS/NA
TGCTTesticular Germ Cell Tumors-0.1980.01320156NANANS/NA
THCAThyroid carcinoma-0.1070.011450509-0.0010.701NS/NA
THYMThymoma-0.0770.4012120NANANS/NA
UCECUterine Corpus Endometrial Carcinoma-0.0450.33834431-0.0030.00407NS/NA
Summary
SymbolDPF3
Namedouble PHD fingers 3
Aliases cer-d4; Cerd4; FLJ14079; BAF45c; BRG1-associated factor 45C; zinc finger protein cer-d4; Zinc finger protein ......
Location14q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Primary tumor tissue from TCGA
> Normal tumor tissue from HPA
>The Cancer Genome Atlas (TCGA)
 
There is no record.
> The Human Protein Atlas (HPA)
 


Tissue Level Level Name
Adrenal gland 2 Medium
Appendix 1 Low
Bone marrow 1 Low
Breast 0 Not detected
Bronchus 0 Not detected
Caudate 2 Medium
Cerebellum 3 High
Cerebral cortex 3 High
Cervix, uterine 0 Not detected
Colon 1 Low
Duodenum 0 Not detected
Endometrium 0 Not detected
Epididymis 0 Not detected
Esophagus 0 Not detected
Fallopian tube 0 Not detected
Gallbladder 0 Not detected
Heart muscle 2 Medium
Hippocampus 1 Low
Kidney 1 Low
Liver 0 Not detected
Lung 0 Not detected
Lymph node 0 Not detected
Nasopharynx 0 Not detected
Oral mucosa 0 Not detected
Ovary 2 Medium
Pancreas 0 Not detected
Parathyroid gland 0 Not detected
Placenta 0 Not detected
Prostate 0 Not detected
Rectum 1 Low
Salivary gland 0 Not detected
Seminal vesicle 0 Not detected
Skeletal muscle 1 Low
Skin 1 Low
Small intestine 0 Not detected
Smooth muscle 0 Not detected
Soft tissue 0 Not detected
Spleen 0 Not detected
Stomach 0 Not detected
Testis 3 High
Thyroid gland 0 Not detected
Tonsil 0 Not detected
Urinary bladder 0 Not detected
Vagina 0 Not detected
Summary
SymbolDPF3
Namedouble PHD fingers 3
Aliases cer-d4; Cerd4; FLJ14079; BAF45c; BRG1-associated factor 45C; zinc finger protein cer-d4; Zinc finger protein ......
Location14q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Association between expresson and subtype
> Overall survival analysis based on expression
> Association between expresson and stage
> Association between expresson and grade
> Subtype
 


  Association between expresson and subtype.
Cancer Full Name # Patients P Value (Kruskal-Wallis) Association Source
BLCABladder urothelial carcinoma1280.534NS24476821
BRCABreast invasive carcinoma5217.24e-23Significant23000897
COADColon adenocarcinoma1490.0181Significant22810696
GBMGlioblastoma multiforme1575.16e-09Significant26824661
HNSCHead and Neck squamous cell carcinoma2792.07e-12Significant25631445
KIRPKidney renal papillary cell carcinoma1610.0915NS26536169
LGGBrain Lower Grade Glioma5132.53e-10Significant26824661
LUADLung adenocarcinoma2300.00493Significant25079552
LUSCLung squamous cell carcinoma1781.52e-09Significant22960745
OVOvarian serous cystadenocarcinoma2871.76e-07Significant21720365
READRectum adenocarcinoma670.981NS22810696
SKCMSkin Cutaneous Melanoma3150.256NS26091043
STADStomach adenocarcinoma2771.79e-10Significant25079317
THCAThyroid carcinoma3912.84e-07Significant25417114
UCECUterine Corpus Endometrial Carcinoma2320.0177Significant23636398
> Overall survival
 

  Overall survival analysis based on expression.
Cancer Full Name # Patients Hazard Ratio P Value (Log Rank Test) Association
BLCABladder urothelial carcinoma405 1.0130.954NS
BRCABreast invasive carcinoma1079 0.9930.975NS
CESCCervical and endocervical cancers291 0.9750.938NS
COADColon adenocarcinoma439 1.0560.854NS
ESCAEsophageal carcinoma184 0.7350.349NS
GBMGlioblastoma multiforme158 1.0640.817NS
HNSCHead and Neck squamous cell carcinoma518 0.9160.657NS
KIRCKidney renal clear cell carcinoma531 0.720.117NS
KIRPKidney renal papillary cell carcinoma287 0.3840.0245Longer
LAMLAcute Myeloid Leukemia149 0.6860.204NS
LGGBrain Lower Grade Glioma511 1.480.119NS
LIHCLiver hepatocellular carcinoma365 0.6380.0628NS
LUADLung adenocarcinoma502 0.7570.173NS
LUSCLung squamous cell carcinoma494 0.7970.237NS
OVOvarian serous cystadenocarcinoma303 0.8140.328NS
PAADPancreatic adenocarcinoma177 0.6760.202NS
PCPGPheochromocytoma and Paraganglioma179 4.4630.143NS
READRectum adenocarcinoma159 0.2840.0568NS
SARCSarcoma259 1.8380.0305Shorter
SKCMSkin Cutaneous Melanoma459 0.6460.0189Longer
STADStomach adenocarcinoma388 1.4560.106NS
TGCTTesticular Germ Cell Tumors134 765937163.7950.113NS
THCAThyroid carcinoma500 0.3850.218NS
THYMThymoma119 1.2510.823NS
UCECUterine Corpus Endometrial Carcinoma543 1.6250.114NS
> Stage
 

  Association between expresson and stage.
Cancer Full Name # Patients R Value (Spearman) P Value (Spearman) Association
BLCABladder urothelial carcinoma406 0.0290.562NS
BRCABreast invasive carcinoma1071 -0.0280.357NS
CESCCervical and endocervical cancers167 -0.090.249NS
COADColon adenocarcinoma445 -0.0430.365NS
ESCAEsophageal carcinoma162 -0.0410.603NS
HNSCHead and Neck squamous cell carcinoma448 -0.1720.000253Lower
KIRCKidney renal clear cell carcinoma531 0.0560.194NS
KIRPKidney renal papillary cell carcinoma260 -0.1490.0163Lower
LIHCLiver hepatocellular carcinoma347 -0.1020.0575NS
LUADLung adenocarcinoma507 -0.1090.0139Lower
LUSCLung squamous cell carcinoma497 -0.0340.444NS
OVOvarian serous cystadenocarcinoma302 0.0560.331NS
PAADPancreatic adenocarcinoma176 -0.1180.12NS
READRectum adenocarcinoma156 0.0980.224NS
SKCMSkin Cutaneous Melanoma410 -0.0450.368NS
STADStomach adenocarcinoma392 0.0570.263NS
TGCTTesticular Germ Cell Tumors81 -0.3270.0029Lower
THCAThyroid carcinoma499 -0.1630.000261Lower
UCECUterine Corpus Endometrial Carcinoma501 0.0410.356NS
> Grade
 

  Association between expresson and grade.
Cancer Full Name # Patients R Value (Spearman) P Value (Spearman) Association
CESCCervical and endocervical cancers272 0.0430.478NS
HNSCHead and Neck squamous cell carcinoma498 0.020.651NS
KIRCKidney renal clear cell carcinoma525 00.993NS
LGGBrain Lower Grade Glioma514 -0.0050.908NS
LIHCLiver hepatocellular carcinoma366 -0.2281.05e-05Lower
OVOvarian serous cystadenocarcinoma296 -0.0270.641NS
PAADPancreatic adenocarcinoma176 -0.1150.129NS
STADStomach adenocarcinoma406 0.24.78e-05Higher
UCECUterine Corpus Endometrial Carcinoma534 0.1670.000107Higher
Summary
SymbolDPF3
Namedouble PHD fingers 3
Aliases cer-d4; Cerd4; FLJ14079; BAF45c; BRG1-associated factor 45C; zinc finger protein cer-d4; Zinc finger protein ......
Location14q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Targets inferred by reverse engineering method
> Targets identified by ChIP-seq data
> Targets inferred by reverse engineering method
 
> Targets identified by ChIP-seq data
 
Summary
SymbolDPF3
Namedouble PHD fingers 3
Aliases cer-d4; Cerd4; FLJ14079; BAF45c; BRG1-associated factor 45C; zinc finger protein cer-d4; Zinc finger protein ......
Location14q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Drugs from DrugBank database
> Drugs from DrugBank database
 
There is no record for DPF3.
Summary
SymbolDPF3
Namedouble PHD fingers 3
Aliases cer-d4; Cerd4; FLJ14079; BAF45c; BRG1-associated factor 45C; zinc finger protein cer-d4; Zinc finger protein ......
Location14q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Protein-Protein Interaction Network
> miRNA Regulatory Relationship
> Interactions from Text Mining
> Protein-Protein Interaction Network
 
> miRNA Regulatory Relationship
 
> Interactions from Text Mining
 
There is no record for DPF3.