Summary | |
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Symbol | DPF3 |
Name | double PHD fingers 3 |
Aliases | cer-d4; Cerd4; FLJ14079; BAF45c; BRG1-associated factor 45C; zinc finger protein cer-d4; Zinc finger protein ...... |
Location | 14q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Cancer Gene Databases | ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes) |
Content |
> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway |
Domain |
PF00628 PHD-finger PF14051 N-terminal domain of DPF2/REQ. |
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Function |
Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Muscle-specific component of the BAF complex, a multiprotein complex involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Specifically binds acetylated lysines on histone 3 and 4 (H3K14ac, H3K9ac, H4K5ac, H4K8ac, H4K12ac, H4K16ac). In the complex, it acts as a tissue-specific anchor between histone acetylations and methylations and chromatin remodeling. It thereby probably plays an essential role in heart and skeletal muscle development. |
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Classification |
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Biological Process | - |
Molecular Function | - |
Cellular Component |
GO:0070603 SWI/SNF superfamily-type complex GO:0071565 nBAF complex GO:0090544 BAF-type complex |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | DPF3 |
Name | double PHD fingers 3 |
Aliases | cer-d4; Cerd4; FLJ14079; BAF45c; BRG1-associated factor 45C; zinc finger protein cer-d4; Zinc finger protein ...... |
Location | 14q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Cancer Gene Databases | ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes) |
Content |
> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining |
There is no record. |
There is no record for DPF3. |
|
Summary | |
---|---|
Symbol | DPF3 |
Name | double PHD fingers 3 |
Aliases | cer-d4; Cerd4; FLJ14079; BAF45c; BRG1-associated factor 45C; zinc finger protein cer-d4; Zinc finger protein ...... |
Location | 14q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Cancer Gene Databases | ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes) |
Content |
> Post-translational modification (PTM) |
There is no PTM data |
Summary | |
---|---|
Symbol | DPF3 |
Name | double PHD fingers 3 |
Aliases | cer-d4; Cerd4; FLJ14079; BAF45c; BRG1-associated factor 45C; zinc finger protein cer-d4; Zinc finger protein ...... |
Location | 14q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Cancer Gene Databases | ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes) |
Content |
> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change |
Differential expression analysis for cancers with more than 10 normal samples
|
There is no record. |
|
There is no record. |
Summary | |
---|---|
Symbol | DPF3 |
Name | double PHD fingers 3 |
Aliases | cer-d4; Cerd4; FLJ14079; BAF45c; BRG1-associated factor 45C; zinc finger protein cer-d4; Zinc finger protein ...... |
Location | 14q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Cancer Gene Databases | ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes) |
Content |
> Somatic copy number alteration in primary tomur tissue |
Correlation between expression and SCNA as well as percentage of patients in different status.
|
Summary | |
---|---|
Symbol | DPF3 |
Name | double PHD fingers 3 |
Aliases | cer-d4; Cerd4; FLJ14079; BAF45c; BRG1-associated factor 45C; zinc finger protein cer-d4; Zinc finger protein ...... |
Location | 14q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Cancer Gene Databases | ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes) |
Content |
> Methylation level in the promoter region of CR |
Correlation between expression and methylation as well as differential methylation analysis.
|
Summary | |
---|---|
Symbol | DPF3 |
Name | double PHD fingers 3 |
Aliases | cer-d4; Cerd4; FLJ14079; BAF45c; BRG1-associated factor 45C; zinc finger protein cer-d4; Zinc finger protein ...... |
Location | 14q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Cancer Gene Databases | ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes) |
Content |
> Primary tumor tissue from TCGA > Normal tumor tissue from HPA |
There is no record. |
|
Summary | |
---|---|
Symbol | DPF3 |
Name | double PHD fingers 3 |
Aliases | cer-d4; Cerd4; FLJ14079; BAF45c; BRG1-associated factor 45C; zinc finger protein cer-d4; Zinc finger protein ...... |
Location | 14q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Cancer Gene Databases | ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes) |
Content |
> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade |
Association between expresson and subtype.
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Overall survival analysis based on expression.
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Association between expresson and stage.
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Association between expresson and grade.
|
Summary | |
---|---|
Symbol | DPF3 |
Name | double PHD fingers 3 |
Aliases | cer-d4; Cerd4; FLJ14079; BAF45c; BRG1-associated factor 45C; zinc finger protein cer-d4; Zinc finger protein ...... |
Location | 14q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Cancer Gene Databases | ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes) |
Content |
> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data |
Summary | |
---|---|
Symbol | DPF3 |
Name | double PHD fingers 3 |
Aliases | cer-d4; Cerd4; FLJ14079; BAF45c; BRG1-associated factor 45C; zinc finger protein cer-d4; Zinc finger protein ...... |
Location | 14q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Cancer Gene Databases | ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes) |
Content |
> Drugs from DrugBank database |
There is no record for DPF3. |
Summary | |
---|---|
Symbol | DPF3 |
Name | double PHD fingers 3 |
Aliases | cer-d4; Cerd4; FLJ14079; BAF45c; BRG1-associated factor 45C; zinc finger protein cer-d4; Zinc finger protein ...... |
Location | 14q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Cancer Gene Databases | ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes) |
Content |
> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining |
There is no record for DPF3. |