CR2Cancer

Summary
Symbol	DUSP1
Name	dual specificity phosphatase 1
Aliases	HVH1; CL100; MKP-1; PTPN10; MKP1; CL 100; MAP kinase phosphatase 1; dual specificity protein phosphatase hVH ......
Location	5q35.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

[ TOP ]

Domain

PF00782 Dual specificity phosphatase
PF00581 Rhodanese-like domain

Function

Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle.

Classification

Class	Modification	Substrate	Product	PubMed
#	#	#	#	#

> Gene Ontology [ TOP ]
Biological Process	GO:0000070 mitotic sister chromatid segregation GO:0000075 cell cycle checkpoint GO:0000188 inactivation of MAPK activity GO:0000302 response to reactive oxygen species GO:0000819 sister chromatid segregation GO:0001101 response to acid chemical GO:0001704 formation of primary germ layer GO:0001706 endoderm formation GO:0001933 negative regulation of protein phosphorylation GO:0006469 negative regulation of protein kinase activity GO:0006470 protein dephosphorylation GO:0006979 response to oxidative stress GO:0007050 cell cycle arrest GO:0007059 chromosome segregation GO:0007067 mitotic nuclear division GO:0007088 regulation of mitotic nuclear division GO:0007091 metaphase/anaphase transition of mitotic cell cycle GO:0007093 mitotic cell cycle checkpoint GO:0007094 mitotic spindle assembly checkpoint GO:0007346 regulation of mitotic cell cycle GO:0007369 gastrulation GO:0007492 endoderm development GO:0009314 response to radiation GO:0009416 response to light stimulus GO:0010035 response to inorganic substance GO:0010038 response to metal ion GO:0010639 negative regulation of organelle organization GO:0010948 negative regulation of cell cycle process GO:0010965 regulation of mitotic sister chromatid separation GO:0014074 response to purine-containing compound GO:0016311 dephosphorylation GO:0030071 regulation of mitotic metaphase/anaphase transition GO:0031577 spindle checkpoint GO:0031960 response to corticosteroid GO:0032355 response to estradiol GO:0032526 response to retinoic acid GO:0033044 regulation of chromosome organization GO:0033045 regulation of sister chromatid segregation GO:0033046 negative regulation of sister chromatid segregation GO:0033047 regulation of mitotic sister chromatid segregation GO:0033048 negative regulation of mitotic sister chromatid segregation GO:0033574 response to testosterone GO:0033673 negative regulation of kinase activity GO:0035335 peptidyl-tyrosine dephosphorylation GO:0035970 peptidyl-threonine dephosphorylation GO:0042326 negative regulation of phosphorylation GO:0042542 response to hydrogen peroxide GO:0043405 regulation of MAP kinase activity GO:0043407 negative regulation of MAP kinase activity GO:0043409 negative regulation of MAPK cascade GO:0044770 cell cycle phase transition GO:0044772 mitotic cell cycle phase transition GO:0044784 metaphase/anaphase transition of cell cycle GO:0045786 negative regulation of cell cycle GO:0045839 negative regulation of mitotic nuclear division GO:0045841 negative regulation of mitotic metaphase/anaphase transition GO:0045930 negative regulation of mitotic cell cycle GO:0046683 response to organophosphorus GO:0048545 response to steroid hormone GO:0051052 regulation of DNA metabolic process GO:0051053 negative regulation of DNA metabolic process GO:0051304 chromosome separation GO:0051306 mitotic sister chromatid separation GO:0051321 meiotic cell cycle GO:0051348 negative regulation of transferase activity GO:0051384 response to glucocorticoid GO:0051445 regulation of meiotic cell cycle GO:0051447 negative regulation of meiotic cell cycle GO:0051591 response to cAMP GO:0051592 response to calcium ion GO:0051783 regulation of nuclear division GO:0051784 negative regulation of nuclear division GO:0051983 regulation of chromosome segregation GO:0051985 negative regulation of chromosome segregation GO:0070371 ERK1 and ERK2 cascade GO:0070372 regulation of ERK1 and ERK2 cascade GO:0070373 negative regulation of ERK1 and ERK2 cascade GO:0071173 spindle assembly checkpoint GO:0071174 mitotic spindle checkpoint GO:0071850 mitotic cell cycle arrest GO:0071897 DNA biosynthetic process GO:0071900 regulation of protein serine/threonine kinase activity GO:0071901 negative regulation of protein serine/threonine kinase activity GO:0090231 regulation of spindle checkpoint GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint GO:0098813 nuclear chromosome segregation GO:1901654 response to ketone GO:1901976 regulation of cell cycle checkpoint GO:1901987 regulation of cell cycle phase transition GO:1901988 negative regulation of cell cycle phase transition GO:1901990 regulation of mitotic cell cycle phase transition GO:1901991 negative regulation of mitotic cell cycle phase transition GO:1902099 regulation of metaphase/anaphase transition of cell cycle GO:1902100 negative regulation of metaphase/anaphase transition of cell cycle GO:1902532 negative regulation of intracellular signal transduction GO:1903504 regulation of mitotic spindle checkpoint GO:2000241 regulation of reproductive process GO:2000242 negative regulation of reproductive process GO:2000278 regulation of DNA biosynthetic process GO:2000279 negative regulation of DNA biosynthetic process GO:2000816 negative regulation of mitotic sister chromatid separation GO:2001251 negative regulation of chromosome organization
Molecular Function	GO:0004721 phosphoprotein phosphatase activity GO:0004725 protein tyrosine phosphatase activity GO:0004726 non-membrane spanning protein tyrosine phosphatase activity GO:0008138 protein tyrosine/serine/threonine phosphatase activity GO:0008330 protein tyrosine/threonine phosphatase activity GO:0016791 phosphatase activity GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity GO:0019838 growth factor binding GO:0033549 MAP kinase phosphatase activity GO:0042578 phosphoric ester hydrolase activity
Cellular Component	-

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04010 MAPK signaling pathway hsa04726 Serotonergic synapse
Reactome	R-HSA-170984: ARMS-mediated activation R-HSA-422475: Axon guidance R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-2172127: DAP12 interactions R-HSA-2424491: DAP12 signaling R-HSA-1266738: Developmental Biology R-HSA-186763: Downstream signal transduction R-HSA-2871796: FCERI mediated MAPK activation R-HSA-2454202: Fc epsilon receptor (FCERI) signaling R-HSA-170968: Frs2-mediated activation R-HSA-179812: GRB2 events in EGFR signaling R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-2428924: IGF1R signaling cascade R-HSA-112399: IRS-mediated signalling R-HSA-2428928: IRS-related events triggered by IGF1R R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-74751: Insulin receptor signalling cascade R-HSA-912526: Interleukin receptor SHC signaling R-HSA-451927: Interleukin-2 signaling R-HSA-512988: Interleukin-3, 5 and GM-CSF signaling R-HSA-5683057: MAPK family signaling cascades R-HSA-5684996: MAPK1/MAPK3 signaling R-HSA-375165: NCAM signaling for neurite out-growth R-HSA-187037: NGF signalling via TRKA from the plasma membrane R-HSA-5675221: Negative regulation of MAPK pathway R-HSA-169893: Prolonged ERK activation events R-HSA-112409: RAF-independent MAPK1/3 activation R-HSA-5673001: RAF/MAP kinase cascade R-HSA-8853659: RET signaling R-HSA-180336: SHC1 events in EGFR signaling R-HSA-112412: SOS-mediated signalling R-HSA-162582: Signal Transduction R-HSA-177929: Signaling by EGFR R-HSA-372790: Signaling by GPCR R-HSA-74752: Signaling by Insulin receptor R-HSA-449147: Signaling by Interleukins R-HSA-2586552: Signaling by Leptin R-HSA-186797: Signaling by PDGF R-HSA-1433557: Signaling by SCF-KIT R-HSA-2404192: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-194138: Signaling by VEGF R-HSA-166520: Signalling by NGF R-HSA-187687: Signalling to ERKs R-HSA-167044: Signalling to RAS R-HSA-187706: Signalling to p38 via RIT and RIN R-HSA-4420097: VEGFA-VEGFR2 Pathway R-HSA-5218921: VEGFR2 mediated cell proliferation

> KEGG and Reactome Pathway

[ TOP ]

KEGG

hsa04010 MAPK signaling pathway
hsa04726 Serotonergic synapse

Reactome

R-HSA-170984: ARMS-mediated activation
R-HSA-422475: Axon guidance
R-HSA-1280215: Cytokine Signaling in Immune system
R-HSA-2172127: DAP12 interactions
R-HSA-2424491: DAP12 signaling
R-HSA-1266738: Developmental Biology
R-HSA-186763: Downstream signal transduction
R-HSA-2871796: FCERI mediated MAPK activation
R-HSA-2454202: Fc epsilon receptor (FCERI) signaling
R-HSA-170968: Frs2-mediated activation
R-HSA-179812: GRB2 events in EGFR signaling
R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK
R-HSA-2428924: IGF1R signaling cascade
R-HSA-112399: IRS-mediated signalling
R-HSA-2428928: IRS-related events triggered by IGF1R
R-HSA-168256: Immune System
R-HSA-168249: Innate Immune System
R-HSA-74751: Insulin receptor signalling cascade
R-HSA-912526: Interleukin receptor SHC signaling
R-HSA-451927: Interleukin-2 signaling
R-HSA-512988: Interleukin-3, 5 and GM-CSF signaling
R-HSA-5683057: MAPK family signaling cascades
R-HSA-5684996: MAPK1/MAPK3 signaling
R-HSA-375165: NCAM signaling for neurite out-growth
R-HSA-187037: NGF signalling via TRKA from the plasma membrane
R-HSA-5675221: Negative regulation of MAPK pathway
R-HSA-169893: Prolonged ERK activation events
R-HSA-112409: RAF-independent MAPK1/3 activation
R-HSA-5673001: RAF/MAP kinase cascade
R-HSA-8853659: RET signaling
R-HSA-180336: SHC1 events in EGFR signaling
R-HSA-112412: SOS-mediated signalling
R-HSA-162582: Signal Transduction
R-HSA-177929: Signaling by EGFR
R-HSA-372790: Signaling by GPCR
R-HSA-74752: Signaling by Insulin receptor
R-HSA-449147: Signaling by Interleukins
R-HSA-2586552: Signaling by Leptin
R-HSA-186797: Signaling by PDGF
R-HSA-1433557: Signaling by SCF-KIT
R-HSA-2404192: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
R-HSA-194138: Signaling by VEGF
R-HSA-166520: Signalling by NGF
R-HSA-187687: Signalling to ERKs
R-HSA-167044: Signalling to RAS
R-HSA-187706: Signalling to p38 via RIT and RIN
R-HSA-4420097: VEGFA-VEGFR2 Pathway
R-HSA-5218921: VEGFR2 mediated cell proliferation

Summary
Symbol	DUSP1
Name	dual specificity phosphatase 1
Aliases	HVH1; CL100; MKP-1; PTPN10; MKP1; CL 100; MAP kinase phosphatase 1; dual specificity protein phosphatase hVH ......
Location	5q35.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM122731	c.904A>G	p.M302V	Substitution - Missense	Upper_aerodigestive_tract
COSM4625510	c.419C>T	p.S140L	Substitution - Missense	Large_intestine
COSM5807315	c.372A>T	p.G124G	Substitution - coding silent	Liver
COSM1065871	c.513+2T>C	p.?	Unknown	Endometrium
COSM5060944	c.654C>A	p.Y218*	Substitution - Nonsense	Stomach
COSM4901153	c.654C>T	p.Y218Y	Substitution - coding silent	Skin
COSM138529	c.1036C>T	p.P346S	Substitution - Missense	Skin
COSM3614200	c.426C>T	p.P142P	Substitution - coding silent	Skin
COSM5356992	c.874C>T	p.R292*	Substitution - Nonsense	Large_intestine
COSM4679697	c.471G>A	p.A157A	Substitution - coding silent	Large_intestine
COSM5633729	c.178A>G	p.M60V	Substitution - Missense	Oesophagus
COSM3614199	c.971C>T	p.P324L	Substitution - Missense	Skin
COSM3853746	c.973G>A	p.A325T	Substitution - Missense	Stomach
COSM1316700	c.1065C>A	p.S355R	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM370176	c.984G>T	p.V328V	Substitution - coding silent	Lung
COSM5964222	c.340C>T	p.R114C	Substitution - Missense	Breast
COSM1186904	c.116A>T	p.H39L	Substitution - Missense	Lung
COSM5620727	c.469G>A	p.A157T	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5427058	c.367+8C>G	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM5643271	c.1035C>G	p.I345M	Substitution - Missense	Oesophagus
COSM4679695	c.1059G>A	p.A353A	Substitution - coding silent	Large_intestine
COSM5403088	c.1079C>T	p.P360L	Substitution - Missense	Skin
COSM3339750	c.1027G>A	p.V343I	Substitution - Missense	Prostate
COSM3339749	c.1050G>A	p.T350T	Substitution - coding silent	Stomach
COSM4679696	c.584T>C	p.L195P	Substitution - Missense	Large_intestine
COSM1250795	c.941C>G	p.A314G	Substitution - Missense	Oesophagus
COSM3853745	c.1061T>C	p.L354P	Substitution - Missense	Stomach
COSM1065867	c.1056T>A	p.S352R	Substitution - Missense	Endometrium
COSM1204715	c.979G>A	p.A327T	Substitution - Missense	Large_intestine
COSM1436049	c.991C>T	p.R331*	Substitution - Nonsense	Large_intestine
COSM117725	c.497C>A	p.T166N	Substitution - Missense	Ovary
COSM250920	c.1023C>A	p.F341L	Substitution - Missense	Liver
COSM5463423	c.671C>A	p.P224H	Substitution - Missense	Large_intestine
COSM1319218	c.1052A>G	p.N351S	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5356992	c.874C>T	p.R292*	Substitution - Nonsense	Large_intestine
COSM449333	c.1011C>T	p.T337T	Substitution - coding silent	Breast
COSM74461	c.616G>A	p.V206I	Substitution - Missense	Ovary
COSM3853747	c.547C>T	p.L183L	Substitution - coding silent	Stomach
COSM5758309	c.36C>T	p.G12G	Substitution - coding silent	Bone
COSM1166645	c.977T>C	p.M326T	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM94148	c.856G>C	p.E286Q	Substitution - Missense	Breast
COSM1250794	c.55delG	p.E19fs*131	Deletion - Frameshift	Oesophagus
COSM94149	c.488C>T	p.S163F	Substitution - Missense	Urinary_tract
COSM3827694	c.595G>A	p.G199S	Substitution - Missense	Breast
COSM5026455	c.715G>A	p.E239K	Substitution - Missense	Breast
COSM3761112	c.166G>A	p.A56T	Substitution - Missense	Large_intestine
COSM216715	c.494G>T	p.S165I	Substitution - Missense	Pancreas
COSM1065869	c.945G>A	p.P315P	Substitution - coding silent	Endometrium
COSM4912781	c.409A>C	p.S137R	Substitution - Missense	Liver
COSM4827600	c.609G>C	p.L203F	Substitution - Missense	Cervix
COSM5403089	c.1017C>T	p.F339F	Substitution - coding silent	Skin
COSM94149	c.488C>T	p.S163F	Substitution - Missense	Breast
COSM3614198	c.1074G>A	p.Q358Q	Substitution - coding silent	Skin
COSM5657201	c.521C>T	p.P174L	Substitution - Missense	Soft_tissue
COSM3381198	c.157C>G	p.R53G	Substitution - Missense	Pancreas
COSM291464	c.854T>A	p.F285Y	Substitution - Missense	Large_intestine
COSM5709646	c.371G>A	p.G124E	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM250920	c.1023C>A	p.F341L	Substitution - Missense	Liver

> Text Mining based Variations [ TOP ]
There is no record for DUSP1.

Summary
Symbol	DUSP1
Name	dual specificity phosphatase 1
Aliases	HVH1; CL100; MKP-1; PTPN10; MKP1; CL 100; MAP kinase phosphatase 1; dual specificity protein phosphatase hVH ......
Location	5q35.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

[ TOP ]

Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
P28562	364	S	Phosphoserine	MAPK1 and MAPK3	No	None detected

Summary
Symbol	DUSP1
Name	dual specificity phosphatase 1
Aliases	HVH1; CL100; MKP-1; PTPN10; MKP1; CL 100; MAP kinase phosphatase 1; dual specificity protein phosphatase hVH ......
Location	5q35.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	10.798	7.099	-3.475	1.7e-18	Under
BRCA	Breast invasive carcinoma	112	1100	9.048	6.766	-2.26	5.17e-58	Under
CESC	Cervical and endocervical cancers	3	306	9.574	7.221	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	7.701	6.265	-1.332	1.68e-12	Under
ESCA	Esophageal carcinoma	11	185	9.201	7.531	-1.19	0.0185	Under
GBM	Glioblastoma multiforme	5	166	6.944	6.978	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	9.43	7.766	-1.629	2.75e-14	Under
KIRC	Kidney renal clear cell carcinoma	72	534	9.04	9.932	0.843	4.87e-10	Over
KIRP	Kidney renal papillary cell carcinoma	32	291	8.639	6.963	-1.677	3.77e-10	Under
LAML	Acute Myeloid Leukemia	0	173	NA	8.74	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	6.068	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	9.111	7.204	-2.019	1.28e-21	Under
LUAD	Lung adenocarcinoma	59	517	9.903	7.832	-1.943	5.49e-25	Under
LUSC	Lung squamous cell carcinoma	51	501	9.945	6.899	-2.933	8.08e-52	Under
OV	Ovarian serous cystadenocarcinoma	0	307	NA	7.169	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	7.382	7.805	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	10.166	8.239	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	9.407	8.748	-0.71	3.52e-05	Under
READ	Rectum adenocarcinoma	10	167	8.149	6.248	-1.586	0.000131	Under
SARC	Sarcoma	2	263	8.558	7.689	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	4.828	5.193	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	8.99	7.304	-1.83	4.53e-15	Under
TGCT	Testicular Germ Cell Tumors	0	156	NA	4.614	NA	NA	NA
THCA	Thyroid carcinoma	59	509	10.405	8.676	-1.314	1.85e-13	Under
THYM	Thymoma	2	120	8.242	5.945	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	9.286	6.005	-3.252	6.51e-42	Under

> Cancer Cell Line Encyclopedia (CCLE)

[ TOP ]

Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	6.2
Autonomic ganglia	CHP212	6.1
Autonomic ganglia	IMR32	6
Autonomic ganglia	KELLY	8.5
Autonomic ganglia	KPNRTBM1	6.4
Autonomic ganglia	KPNSI9S	6.4
Autonomic ganglia	KPNYN	7.1
Autonomic ganglia	MHHNB11	6.3
Autonomic ganglia	NB1	6.7
Autonomic ganglia	NH6	7.8
Autonomic ganglia	SHSY5Y	7.7
Autonomic ganglia	SIMA	8.8
Autonomic ganglia	SKNAS	6.9
Autonomic ganglia	SKNBE2	7.3
Autonomic ganglia	SKNDZ	6.4
Autonomic ganglia	SKNFI	5.7
Autonomic ganglia	SKNSH	8.6
Biliary tract	HUCCT1	8.2
Biliary tract	HUH28	7.2
Biliary tract	SNU1079	9.4
Biliary tract	SNU1196	6.4
Biliary tract	SNU245	6.5
Biliary tract	SNU308	6.8
Biliary tract	SNU478	8.9
Bone	143B	9.1
Bone	A673	6.8
Bone	CADOES1	7.8
Bone	CAL78	9.2
Bone	G292CLONEA141B1	6.9
Bone	HOS	8.4
Bone	HS706T	8.2
Bone	HS737T	8.7
Bone	HS819T	8.7
Bone	HS821T	9
Bone	HS822T	9.6
Bone	HS863T	9.6
Bone	HS870T	9.4
Bone	HS888T	11.5
Bone	MG63	9.8
Bone	MHHES1	7.6
Bone	OUMS27	7.1
Bone	RDES	5.8
Bone	SJSA1	9.4
Bone	SKES1	6
Bone	SKNMC	7.5
Bone	SW1353	7.5
Bone	T173	8.8
Bone	TC71	6.1
Bone	U2OS	8
Breast	AU565	6.2
Breast	BT20	8.2
Breast	BT474	7.5
Breast	BT483	7.2
Breast	BT549	7.3
Breast	CAL120	8.9
Breast	CAL148	8.2
Breast	CAL51	5.9
Breast	CAL851	7.2
Breast	CAMA1	9.1
Breast	DU4475	4.8
Breast	EFM192A	8.8
Breast	EFM19	6.2
Breast	EVSAT	7.3
Breast	HCC1143	6.7
Breast	HCC1187	5.6
Breast	HCC1395	6.3
Breast	HCC1419	9.9
Breast	HCC1428	8.5
Breast	HCC1500	8.7
Breast	HCC1569	6
Breast	HCC1599	6.8
Breast	HCC1806	6.4
Breast	HCC1937	7.8
Breast	HCC1954	7.4
Breast	HCC202	6.5
Breast	HCC2157	5.6
Breast	HCC2218	7.2
Breast	HCC38	8.2
Breast	HCC70	7.3
Breast	HDQP1	9.3
Breast	HMC18	7.5
Breast	HS274T	9.1
Breast	HS281T	9
Breast	HS343T	9.4
Breast	HS578T	9.4
Breast	HS606T	8.6
Breast	HS739T	8.2
Breast	HS742T	9.2
Breast	JIMT1	9.8
Breast	KPL1	7.8
Breast	MCF7	7.6
Breast	MDAMB134VI	8.1
Breast	MDAMB157	5.7
Breast	MDAMB175VII	5.2
Breast	MDAMB231	8
Breast	MDAMB361	6.5
Breast	MDAMB415	6.4
Breast	MDAMB436	8.4
Breast	MDAMB453	8.8
Breast	MDAMB468	6.2
Breast	SKBR3	6.7
Breast	T47D	5.5
Breast	UACC812	7.5
Breast	UACC893	8.8
Breast	YMB1	7.5
Breast	ZR751	9.5
Breast	ZR7530	8.6
Central nervous system	1321N1	9
Central nervous system	42MGBA	9.9
Central nervous system	8MGBA	6.8
Central nervous system	A172	9.3
Central nervous system	AM38	8.8
Central nervous system	BECKER	7.4
Central nervous system	CAS1	6.6
Central nervous system	CCFSTTG1	7.4
Central nervous system	D283MED	6.5
Central nervous system	D341MED	6.6
Central nervous system	DAOY	6.7
Central nervous system	DBTRG05MG	6.7
Central nervous system	DKMG	6.7
Central nervous system	GAMG	9
Central nervous system	GB1	7.2
Central nervous system	GI1	8.5
Central nervous system	GMS10	8.9
Central nervous system	GOS3	9.4
Central nervous system	H4	7
Central nervous system	HS683	6.9
Central nervous system	KALS1	7.6
Central nervous system	KG1C	9.2
Central nervous system	KNS42	7.6
Central nervous system	KNS60	8.2
Central nervous system	KNS81	8.6
Central nervous system	KS1	9.3
Central nervous system	LN18	6.1
Central nervous system	LN229	5
Central nervous system	M059K	9.3
Central nervous system	MOGGCCM	6.9
Central nervous system	MOGGUVW	8.4
Central nervous system	NMCG1	8.1
Central nervous system	ONS76	5
Central nervous system	SF126	8.1
Central nervous system	SF295	6.8
Central nervous system	SNB19	7.5
Central nervous system	SNU1105	9
Central nervous system	SNU201	7.8
Central nervous system	SNU466	5.9
Central nervous system	SNU489	9.3
Central nervous system	SNU626	6.7
Central nervous system	SNU738	8.9
Central nervous system	SW1088	9.4
Central nervous system	SW1783	8
Central nervous system	T98G	7.9
Central nervous system	TM31	7.9
Central nervous system	U118MG	7.4
Central nervous system	U138MG	9
Central nervous system	U251MG	7.9
Central nervous system	U87MG	8.1
Central nervous system	YH13	8.7
Central nervous system	YKG1	7.9
Endometrium	AN3CA	6.7
Endometrium	COLO684	7.9
Endometrium	EFE184	7.6
Endometrium	EN	7.3
Endometrium	ESS1	7.9
Endometrium	HEC108	8.9
Endometrium	HEC151	7.8
Endometrium	HEC1A	8.2
Endometrium	HEC1B	9.2
Endometrium	HEC251	6.6
Endometrium	HEC265	6.5
Endometrium	HEC50B	8.9
Endometrium	HEC59	8
Endometrium	HEC6	4.5
Endometrium	ISHIKAWAHERAKLIO02ER	5.4
Endometrium	JHUEM1	7
Endometrium	JHUEM2	7
Endometrium	JHUEM3	8
Endometrium	KLE	9
Endometrium	MFE280	6.6
Endometrium	MFE296	5.7
Endometrium	MFE319	7.7
Endometrium	RL952	8.4
Endometrium	SNGM	7.3
Endometrium	SNU1077	9.5
Endometrium	SNU685	6.9
Endometrium	TEN	8.9
Haematopoietic and lymphoid	697	8.7
Haematopoietic and lymphoid	A3KAW	6.2
Haematopoietic and lymphoid	A4FUK	6.5
Haematopoietic and lymphoid	ALLSIL	4.7
Haematopoietic and lymphoid	AML193	4.7
Haematopoietic and lymphoid	AMO1	6
Haematopoietic and lymphoid	BCP1	5.1
Haematopoietic and lymphoid	BDCM	4.9
Haematopoietic and lymphoid	BL41	4.9
Haematopoietic and lymphoid	BL70	4.9
Haematopoietic and lymphoid	BV173	7.3
Haematopoietic and lymphoid	CA46	5.4
Haematopoietic and lymphoid	CI1	5.3
Haematopoietic and lymphoid	CMK115	4.6
Haematopoietic and lymphoid	CMK86	4.8
Haematopoietic and lymphoid	CMK	5.2
Haematopoietic and lymphoid	CMLT1	6.8
Haematopoietic and lymphoid	COLO775	8.3
Haematopoietic and lymphoid	DAUDI	5.2
Haematopoietic and lymphoid	DB	4.8
Haematopoietic and lymphoid	DEL	8.5
Haematopoietic and lymphoid	DND41	5.5
Haematopoietic and lymphoid	DOHH2	4.9
Haematopoietic and lymphoid	EB1	5.4
Haematopoietic and lymphoid	EB2	4.7
Haematopoietic and lymphoid	EHEB	5.7
Haematopoietic and lymphoid	EJM	8.2
Haematopoietic and lymphoid	EM2	5
Haematopoietic and lymphoid	EOL1	5.3
Haematopoietic and lymphoid	F36P	5.4
Haematopoietic and lymphoid	GA10	5.1
Haematopoietic and lymphoid	GDM1	4.5
Haematopoietic and lymphoid	GRANTA519	5.4
Haematopoietic and lymphoid	HDLM2	9.1
Haematopoietic and lymphoid	HDMYZ	9.8
Haematopoietic and lymphoid	HEL9217	5.4
Haematopoietic and lymphoid	HEL	4.9
Haematopoietic and lymphoid	HH	5.6
Haematopoietic and lymphoid	HL60	4.5
Haematopoietic and lymphoid	HPBALL	6.7
Haematopoietic and lymphoid	HS604T	9
Haematopoietic and lymphoid	HS611T	5
Haematopoietic and lymphoid	HS616T	8.9
Haematopoietic and lymphoid	HS751T	8.1
Haematopoietic and lymphoid	HT	5.1
Haematopoietic and lymphoid	HTK	9.6
Haematopoietic and lymphoid	HUNS1	5.2
Haematopoietic and lymphoid	HUT102	8.7
Haematopoietic and lymphoid	HUT78	4.9
Haematopoietic and lymphoid	JEKO1	5.8
Haematopoietic and lymphoid	JK1	8.9
Haematopoietic and lymphoid	JM1	4.9
Haematopoietic and lymphoid	JURKAT	5.6
Haematopoietic and lymphoid	JURLMK1	5.8
Haematopoietic and lymphoid	JVM2	6.9
Haematopoietic and lymphoid	JVM3	6.2
Haematopoietic and lymphoid	K562	6.7
Haematopoietic and lymphoid	KARPAS299	7.3
Haematopoietic and lymphoid	KARPAS422	5.4
Haematopoietic and lymphoid	KARPAS620	5.9
Haematopoietic and lymphoid	KASUMI1	5.2
Haematopoietic and lymphoid	KASUMI2	9.6
Haematopoietic and lymphoid	KASUMI6	4.8
Haematopoietic and lymphoid	KCL22	5.5
Haematopoietic and lymphoid	KE37	6.1
Haematopoietic and lymphoid	KE97	5.2
Haematopoietic and lymphoid	KG1	5.5
Haematopoietic and lymphoid	KHM1B	5
Haematopoietic and lymphoid	KIJK	8
Haematopoietic and lymphoid	KMH2	6
Haematopoietic and lymphoid	KMM1	5.6
Haematopoietic and lymphoid	KMS11	10
Haematopoietic and lymphoid	KMS12BM	4.9
Haematopoietic and lymphoid	KMS18	6.5
Haematopoietic and lymphoid	KMS20	5.4
Haematopoietic and lymphoid	KMS21BM	4.4
Haematopoietic and lymphoid	KMS26	5.9
Haematopoietic and lymphoid	KMS27	5.9
Haematopoietic and lymphoid	KMS28BM	6.1
Haematopoietic and lymphoid	KMS34	7.1
Haematopoietic and lymphoid	KO52	4.8
Haematopoietic and lymphoid	KOPN8	8.9
Haematopoietic and lymphoid	KU812	5.8
Haematopoietic and lymphoid	KYO1	6
Haematopoietic and lymphoid	L1236	5.5
Haematopoietic and lymphoid	L363	5.7
Haematopoietic and lymphoid	L428	7.1
Haematopoietic and lymphoid	L540	8.4
Haematopoietic and lymphoid	LAMA84	5.6
Haematopoietic and lymphoid	LOUCY	5.4
Haematopoietic and lymphoid	LP1	7.9
Haematopoietic and lymphoid	M07E	4.8
Haematopoietic and lymphoid	MC116	4.8
Haematopoietic and lymphoid	ME1	4.5
Haematopoietic and lymphoid	MEC1	5.2
Haematopoietic and lymphoid	MEC2	5
Haematopoietic and lymphoid	MEG01	6.5
Haematopoietic and lymphoid	MHHCALL2	7.4
Haematopoietic and lymphoid	MHHCALL3	9.9
Haematopoietic and lymphoid	MHHCALL4	8.3
Haematopoietic and lymphoid	MINO	6.3
Haematopoietic and lymphoid	MJ	6.3
Haematopoietic and lymphoid	MM1S	7.6
Haematopoietic and lymphoid	MOLM13	5.5
Haematopoietic and lymphoid	MOLM16	5
Haematopoietic and lymphoid	MOLM6	5.6
Haematopoietic and lymphoid	MOLP2	5
Haematopoietic and lymphoid	MOLP8	6
Haematopoietic and lymphoid	MOLT13	5.7
Haematopoietic and lymphoid	MOLT16	4.8
Haematopoietic and lymphoid	MOLT4	5.2
Haematopoietic and lymphoid	MONOMAC1	5.1
Haematopoietic and lymphoid	MONOMAC6	5
Haematopoietic and lymphoid	MOTN1	5.3
Haematopoietic and lymphoid	MUTZ5	8.7
Haematopoietic and lymphoid	MV411	4.7
Haematopoietic and lymphoid	NALM19	8.7
Haematopoietic and lymphoid	NALM1	8.5
Haematopoietic and lymphoid	NALM6	9.5
Haematopoietic and lymphoid	NAMALWA	5.7
Haematopoietic and lymphoid	NB4	5.1
Haematopoietic and lymphoid	NCIH929	5.8
Haematopoietic and lymphoid	NCO2	5.2
Haematopoietic and lymphoid	NOMO1	4.4
Haematopoietic and lymphoid	NUDHL1	6.5
Haematopoietic and lymphoid	NUDUL1	6.5
Haematopoietic and lymphoid	OCIAML2	4.3
Haematopoietic and lymphoid	OCIAML3	5.4
Haematopoietic and lymphoid	OCIAML5	5.5
Haematopoietic and lymphoid	OCILY10	5.6
Haematopoietic and lymphoid	OCILY19	9
Haematopoietic and lymphoid	OCILY3	5.3
Haematopoietic and lymphoid	OCIM1	5.5
Haematopoietic and lymphoid	OPM2	5.6
Haematopoietic and lymphoid	P12ICHIKAWA	5
Haematopoietic and lymphoid	P31FUJ	4.9
Haematopoietic and lymphoid	P3HR1	5.1
Haematopoietic and lymphoid	PCM6	5.1
Haematopoietic and lymphoid	PEER	6
Haematopoietic and lymphoid	PF382	5.8
Haematopoietic and lymphoid	PFEIFFER	4.9
Haematopoietic and lymphoid	PL21	5.9
Haematopoietic and lymphoid	RAJI	5.2
Haematopoietic and lymphoid	RCHACV	8.6
Haematopoietic and lymphoid	REC1	5.5
Haematopoietic and lymphoid	REH	9.7
Haematopoietic and lymphoid	RI1	5.9
Haematopoietic and lymphoid	RL	5.8
Haematopoietic and lymphoid	RPMI8226	6.4
Haematopoietic and lymphoid	RPMI8402	4.8
Haematopoietic and lymphoid	RS411	8
Haematopoietic and lymphoid	SEM	7.4
Haematopoietic and lymphoid	SET2	4.8
Haematopoietic and lymphoid	SIGM5	5.2
Haematopoietic and lymphoid	SKM1	5.3
Haematopoietic and lymphoid	SKMM2	5.7
Haematopoietic and lymphoid	SR786	5.9
Haematopoietic and lymphoid	ST486	5
Haematopoietic and lymphoid	SUDHL10	5
Haematopoietic and lymphoid	SUDHL1	6.3
Haematopoietic and lymphoid	SUDHL4	5.4
Haematopoietic and lymphoid	SUDHL5	5
Haematopoietic and lymphoid	SUDHL6	4.3
Haematopoietic and lymphoid	SUDHL8	6.5
Haematopoietic and lymphoid	SUPB15	7.1
Haematopoietic and lymphoid	SUPHD1	7
Haematopoietic and lymphoid	SUPM2	6.8
Haematopoietic and lymphoid	SUPT11	5
Haematopoietic and lymphoid	SUPT1	6.3
Haematopoietic and lymphoid	TALL1	4.9
Haematopoietic and lymphoid	TF1	4.3
Haematopoietic and lymphoid	THP1	4.6
Haematopoietic and lymphoid	TO175T	9.9
Haematopoietic and lymphoid	TOLEDO	5.9
Haematopoietic and lymphoid	U266B1	6
Haematopoietic and lymphoid	U937	4.7
Haematopoietic and lymphoid	UT7	4.7
Haematopoietic and lymphoid	WSUDLCL2	5.5
Kidney	769P	9.1
Kidney	786O	8.5
Kidney	A498	8.5
Kidney	A704	8.9
Kidney	ACHN	9
Kidney	BFTC909	8.2
Kidney	CAKI1	8
Kidney	CAKI2	8.3
Kidney	CAL54	9
Kidney	KMRC1	8.4
Kidney	KMRC20	8.8
Kidney	KMRC2	10.1
Kidney	KMRC3	10.7
Kidney	OSRC2	9.9
Kidney	RCC10RGB	10.2
Kidney	SNU1272	10.4
Kidney	SNU349	9.8
Kidney	TUHR10TKB	10.7
Kidney	TUHR14TKB	10.2
Kidney	TUHR4TKB	10.7
Kidney	VMRCRCW	10
Kidney	VMRCRCZ	8.9
Large intestine	C2BBE1	7.9
Large intestine	CCK81	4.7
Large intestine	CL11	7.8
Large intestine	CL14	7.3
Large intestine	CL34	6.6
Large intestine	CL40	7.1
Large intestine	COLO205	4.9
Large intestine	COLO320	5.9
Large intestine	COLO678	6.8
Large intestine	CW2	8.9
Large intestine	DLD1	5.8
Large intestine	GP2D	6.3
Large intestine	HCC56	5.5
Large intestine	HCT116	6
Large intestine	HCT15	6.7
Large intestine	HS675T	8
Large intestine	HS698T	9.1
Large intestine	HT115	7.2
Large intestine	HT29	6.1
Large intestine	HT55	6.2
Large intestine	KM12	5.9
Large intestine	LOVO	7.2
Large intestine	LS1034	6.2
Large intestine	LS123	8.1
Large intestine	LS180	5.1
Large intestine	LS411N	5.2
Large intestine	LS513	6.8
Large intestine	MDST8	6.8
Large intestine	NCIH508	6.9
Large intestine	NCIH716	5.3
Large intestine	NCIH747	6.7
Large intestine	OUMS23	6.4
Large intestine	RCM1	6.7
Large intestine	RKO	6.4
Large intestine	SKCO1	5.3
Large intestine	SNU1040	6.1
Large intestine	SNU1197	7.5
Large intestine	SNU175	6.8
Large intestine	SNU283	6.5
Large intestine	SNU407	6.6
Large intestine	SNU503	5.5
Large intestine	SNU61	7.3
Large intestine	SNU81	7.1
Large intestine	SNUC1	5
Large intestine	SNUC2A	6.2
Large intestine	SNUC4	7.7
Large intestine	SNUC5	7
Large intestine	SW1116	6
Large intestine	SW1417	6.3
Large intestine	SW1463	6.7
Large intestine	SW403	6
Large intestine	SW480	5.4
Large intestine	SW48	5.6
Large intestine	SW620	5.3
Large intestine	SW837	5.9
Large intestine	SW948	6.6
Large intestine	T84	6.4
Liver	ALEXANDERCELLS	8.8
Liver	C3A	6.8
Liver	HEP3B217	7.9
Liver	HEPG2	7
Liver	HLE	9.1
Liver	HLF	9.4
Liver	HUH1	8
Liver	HUH6	7
Liver	HUH7	8.9
Liver	JHH1	9.1
Liver	JHH2	8.9
Liver	JHH4	7.3
Liver	JHH5	6.5
Liver	JHH6	7.1
Liver	JHH7	6.2
Liver	LI7	8.3
Liver	PLCPRF5	10.5
Liver	SKHEP1	6.8
Liver	SNU182	10.6
Liver	SNU387	8.8
Liver	SNU398	5.8
Liver	SNU423	8.9
Liver	SNU449	7.8
Liver	SNU475	7.4
Liver	SNU761	9.5
Liver	SNU878	7.6
Liver	SNU886	9.3
Lung	A549	9.4
Lung	ABC1	9.7
Lung	BEN	5.3
Lung	CAL12T	6
Lung	CALU1	8.5
Lung	CALU3	6.3
Lung	CALU6	5.7
Lung	CHAGOK1	8.6
Lung	COLO668	6.8
Lung	COLO699	8.4
Lung	CORL105	9.7
Lung	CORL23	6.6
Lung	CORL24	5.9
Lung	CORL279	6
Lung	CORL311	5.3
Lung	CORL47	7.1
Lung	CORL51	6.1
Lung	CORL88	5.6
Lung	CORL95	6.1
Lung	CPCN	5.5
Lung	DMS114	5.9
Lung	DMS153	5.4
Lung	DMS273	6.5
Lung	DMS454	7
Lung	DMS53	7
Lung	DMS79	5.5
Lung	DV90	4.9
Lung	EBC1	7.1
Lung	EPLC272H	6.2
Lung	HARA	6.8
Lung	HCC1171	8.1
Lung	HCC1195	6.7
Lung	HCC15	7.6
Lung	HCC2279	9.2
Lung	HCC2935	7
Lung	HCC33	6.2
Lung	HCC366	7.6
Lung	HCC4006	7.7
Lung	HCC44	9
Lung	HCC78	9.9
Lung	HCC827	8.9
Lung	HCC95	7
Lung	HLC1	8.1
Lung	HLFA	10
Lung	HS229T	9.6
Lung	HS618T	9.4
Lung	IALM	8.1
Lung	KNS62	5.7
Lung	LC1F	6.5
Lung	LC1SQSF	7.7
Lung	LCLC103H	10
Lung	LCLC97TM1	6.2
Lung	LK2	7.6
Lung	LOUNH91	9
Lung	LU65	7.7
Lung	LU99	9.4
Lung	LUDLU1	5.6
Lung	LXF289	9.5
Lung	MORCPR	9.4
Lung	NCIH1048	5.9
Lung	NCIH1092	5.2
Lung	NCIH1105	5.9
Lung	NCIH1155	5.2
Lung	NCIH1184	6.6
Lung	NCIH1299	8.6
Lung	NCIH1339	7.5
Lung	NCIH1341	6.2
Lung	NCIH1355	6.9
Lung	NCIH1373	6.4
Lung	NCIH1385	8.8
Lung	NCIH1395	9.9
Lung	NCIH1435	6.6
Lung	NCIH1436	4.8
Lung	NCIH1437	8.8
Lung	NCIH146	5.4
Lung	NCIH1563	10.7
Lung	NCIH1568	9.5
Lung	NCIH1573	6.9
Lung	NCIH1581	5.4
Lung	NCIH1618	6.5
Lung	NCIH1623	6.8
Lung	NCIH1648	7.6
Lung	NCIH1650	7.9
Lung	NCIH1651	7.5
Lung	NCIH1666	7.2
Lung	NCIH1693	8.4
Lung	NCIH1694	6.2
Lung	NCIH1703	8.1
Lung	NCIH1734	9
Lung	NCIH1755	8.6
Lung	NCIH1781	7.9
Lung	NCIH1792	5.9
Lung	NCIH1793	9.2
Lung	NCIH1836	4.9
Lung	NCIH1838	9.1
Lung	NCIH1869	7
Lung	NCIH1876	6.2
Lung	NCIH1915	10.4
Lung	NCIH1930	6.2
Lung	NCIH1944	9.4
Lung	NCIH1963	5.8
Lung	NCIH196	6.2
Lung	NCIH1975	7.9
Lung	NCIH2009	7.1
Lung	NCIH2023	8.7
Lung	NCIH2029	7.3
Lung	NCIH2030	8.4
Lung	NCIH2066	6.6
Lung	NCIH2081	5.3
Lung	NCIH2085	6.4
Lung	NCIH2087	7.3
Lung	NCIH209	6.3
Lung	NCIH2106	5.4
Lung	NCIH2110	7.7
Lung	NCIH211	4.9
Lung	NCIH2122	8.6
Lung	NCIH2126	8.9
Lung	NCIH2141	5.7
Lung	NCIH2170	7.8
Lung	NCIH2171	6.4
Lung	NCIH2172	8.2
Lung	NCIH2196	5.7
Lung	NCIH2227	6.1
Lung	NCIH2228	10.4
Lung	NCIH226	10.2
Lung	NCIH2286	7.3
Lung	NCIH2291	9.8
Lung	NCIH2342	6.1
Lung	NCIH2347	7.5
Lung	NCIH23	6.8
Lung	NCIH2405	8.6
Lung	NCIH2444	8.7
Lung	NCIH292	9.6
Lung	NCIH322	6.5
Lung	NCIH3255	6.6
Lung	NCIH358	6
Lung	NCIH441	5.8
Lung	NCIH446	6.7
Lung	NCIH460	8
Lung	NCIH510	7.5
Lung	NCIH520	5.4
Lung	NCIH522	6.6
Lung	NCIH524	6.1
Lung	NCIH526	5.5
Lung	NCIH596	9.3
Lung	NCIH647	8.3
Lung	NCIH650	7.7
Lung	NCIH661	7.1
Lung	NCIH69	5.2
Lung	NCIH727	8.1
Lung	NCIH810	10.2
Lung	NCIH82	5.4
Lung	NCIH838	9.9
Lung	NCIH841	6.7
Lung	NCIH854	6.3
Lung	NCIH889	5.1
Lung	PC14	7.6
Lung	RERFLCAD1	7.7
Lung	RERFLCAD2	8.2
Lung	RERFLCAI	8.8
Lung	RERFLCKJ	10.4
Lung	RERFLCMS	10.2
Lung	RERFLCSQ1	8
Lung	SBC5	6.1
Lung	SCLC21H	7.4
Lung	SHP77	8.3
Lung	SKLU1	8.6
Lung	SKMES1	6.4
Lung	SQ1	9.7
Lung	SW1271	8.9
Lung	SW1573	8.5
Lung	SW900	8.5
Lung	VMRCLCD	8.9
Lung	VMRCLCP	8.2
Oesophagus	COLO680N	7.7
Oesophagus	ECGI10	8.1
Oesophagus	KYSE140	5.2
Oesophagus	KYSE150	9.9
Oesophagus	KYSE180	7.1
Oesophagus	KYSE270	7.4
Oesophagus	KYSE30	11.6
Oesophagus	KYSE410	8
Oesophagus	KYSE450	5.9
Oesophagus	KYSE510	9.7
Oesophagus	KYSE520	7.6
Oesophagus	KYSE70	5.8
Oesophagus	OE19	8.5
Oesophagus	OE33	6.5
Oesophagus	TE10	6.5
Oesophagus	TE11	6.6
Oesophagus	TE14	8.6
Oesophagus	TE15	8.9
Oesophagus	TE1	10.7
Oesophagus	TE4	7.2
Oesophagus	TE5	10.2
Oesophagus	TE6	7.8
Oesophagus	TE8	10.3
Oesophagus	TE9	9.3
Oesophagus	TT	7.9
Ovary	59M	9.8
Ovary	A2780	5.2
Ovary	CAOV3	8.5
Ovary	CAOV4	7.9
Ovary	COLO704	6.5
Ovary	COV318	8.4
Ovary	COV362	8.5
Ovary	COV434	6.5
Ovary	COV504	8.6
Ovary	COV644	9.4
Ovary	EFO21	9.7
Ovary	EFO27	5.7
Ovary	ES2	8.6
Ovary	FUOV1	7.9
Ovary	HEYA8	8.9
Ovary	HS571T	8.7
Ovary	IGROV1	7.4
Ovary	JHOC5	9.1
Ovary	JHOM1	9.7
Ovary	JHOM2B	7.7
Ovary	JHOS2	10.2
Ovary	JHOS4	9
Ovary	KURAMOCHI	7
Ovary	MCAS	7.3
Ovary	NIHOVCAR3	7
Ovary	OAW28	6.3
Ovary	OAW42	9.5
Ovary	OC314	9.7
Ovary	OC316	9.6
Ovary	ONCODG1	7.5
Ovary	OV56	10.7
Ovary	OV7	8.6
Ovary	OV90	5.9
Ovary	OVCAR4	8.9
Ovary	OVCAR8	8.5
Ovary	OVISE	7.2
Ovary	OVK18	7.4
Ovary	OVKATE	6.6
Ovary	OVMANA	8.6
Ovary	OVSAHO	6.9
Ovary	OVTOKO	8
Ovary	RMGI	8.5
Ovary	RMUGS	8.1
Ovary	SKOV3	9.9
Ovary	SNU119	8.3
Ovary	SNU840	9.6
Ovary	SNU8	8.9
Ovary	TOV112D	5.5
Ovary	TOV21G	8.6
Ovary	TYKNU	10
Pancreas	ASPC1	8
Pancreas	BXPC3	6.6
Pancreas	CAPAN1	6.8
Pancreas	CAPAN2	7.1
Pancreas	CFPAC1	7.1
Pancreas	DANG	6.1
Pancreas	HPAC	7.1
Pancreas	HPAFII	8.5
Pancreas	HS766T	6.7
Pancreas	HUPT3	7.2
Pancreas	HUPT4	6.1
Pancreas	KCIMOH1	9.2
Pancreas	KLM1	7.7
Pancreas	KP2	7.7
Pancreas	KP3	8.1
Pancreas	KP4	8.1
Pancreas	L33	6.8
Pancreas	MIAPACA2	7
Pancreas	PANC0203	7
Pancreas	PANC0213	7
Pancreas	PANC0327	5.4
Pancreas	PANC0403	5.6
Pancreas	PANC0504	7.5
Pancreas	PANC0813	5.8
Pancreas	PANC1005	7.1
Pancreas	PANC1	8.6
Pancreas	PATU8902	6.8
Pancreas	PATU8988S	6.6
Pancreas	PATU8988T	8.2
Pancreas	PK1	9.1
Pancreas	PK45H	9.4
Pancreas	PK59	8.8
Pancreas	PL45	7.8
Pancreas	PSN1	6.5
Pancreas	QGP1	7.4
Pancreas	SNU213	8.7
Pancreas	SNU324	8.1
Pancreas	SNU410	8.3
Pancreas	SU8686	7
Pancreas	SUIT2	6.3
Pancreas	SW1990	7.3
Pancreas	T3M4	7.6
Pancreas	TCCPAN2	8.3
Pancreas	YAPC	7
Pleura	ACCMESO1	9.4
Pleura	DM3	10.4
Pleura	ISTMES1	10.3
Pleura	ISTMES2	10.3
Pleura	JL1	10.1
Pleura	MPP89	9.9
Pleura	MSTO211H	8
Pleura	NCIH2052	9.5
Pleura	NCIH2452	8.1
Pleura	NCIH28	8.7
Prostate	22RV1	6.6
Prostate	DU145	9.3
Prostate	LNCAPCLONEFGC	7.9
Prostate	MDAPCA2B	7.1
Prostate	NCIH660	6.8
Prostate	PC3	6.7
Prostate	VCAP	6.4
Salivary gland	A253	6.4
Salivary gland	YD15	5.4
Skin	A101D	5.3
Skin	A2058	5.2
Skin	A375	6.2
Skin	C32	6.4
Skin	CHL1	7
Skin	CJM	6.8
Skin	COLO679	6.8
Skin	COLO741	8
Skin	COLO783	5.3
Skin	COLO792	7.3
Skin	COLO800	5
Skin	COLO818	5.6
Skin	COLO829	5.1
Skin	COLO849	5.1
Skin	G361	5.5
Skin	GRM	9
Skin	HMCB	7.5
Skin	HS294T	6.2
Skin	HS600T	9.4
Skin	HS688AT	9.3
Skin	HS695T	5.8
Skin	HS839T	8.6
Skin	HS852T	6.1
Skin	HS895T	9.7
Skin	HS934T	9.2
Skin	HS936T	6.9
Skin	HS939T	6.5
Skin	HS940T	8.8
Skin	HS944T	6.1
Skin	HT144	6.1
Skin	IGR1	5.7
Skin	IGR37	5.7
Skin	IGR39	5.9
Skin	IPC298	5.2
Skin	K029AX	5.8
Skin	LOXIMVI	9.4
Skin	MALME3M	5.1
Skin	MDAMB435S	5
Skin	MELHO	5.3
Skin	MELJUSO	7.1
Skin	MEWO	6.7
Skin	RPMI7951	6.9
Skin	RVH421	5.9
Skin	SH4	8.8
Skin	SKMEL1	6.3
Skin	SKMEL24	6.4
Skin	SKMEL28	5.5
Skin	SKMEL2	7.1
Skin	SKMEL30	5.8
Skin	SKMEL31	5.3
Skin	SKMEL3	6.6
Skin	SKMEL5	5.6
Skin	UACC257	7.8
Skin	UACC62	6.8
Skin	WM115	5.9
Skin	WM1799	5.5
Skin	WM2664	4.7
Skin	WM793	6.8
Skin	WM88	4.8
Skin	WM983B	5.7
Small intestine	HUTU80	6.1
Soft tissue	A204	7.1
Soft tissue	G401	7.3
Soft tissue	G402	8.6
Soft tissue	GCT	7.1
Soft tissue	HS729	9.9
Soft tissue	HT1080	7.4
Soft tissue	KYM1	7.3
Soft tissue	MESSA	5.3
Soft tissue	RD	7
Soft tissue	RH30	7.5
Soft tissue	RH41	6.3
Soft tissue	RKN	10
Soft tissue	S117	9.1
Soft tissue	SJRH30	6.3
Soft tissue	SKLMS1	7.7
Soft tissue	SKUT1	7.3
Soft tissue	TE125T	9.7
Soft tissue	TE159T	9.4
Soft tissue	TE441T	7.8
Soft tissue	TE617T	8.2
Stomach	2313287	7.9
Stomach	AGS	6.8
Stomach	AZ521	5.6
Stomach	ECC10	7.9
Stomach	ECC12	8.1
Stomach	FU97	7
Stomach	GCIY	6.8
Stomach	GSS	6.9
Stomach	GSU	7.6
Stomach	HGC27	7.5
Stomach	HS746T	7.5
Stomach	HUG1N	8.1
Stomach	IM95	7.4
Stomach	KATOIII	6.2
Stomach	KE39	8.6
Stomach	LMSU	8.2
Stomach	MKN1	8.1
Stomach	MKN45	6.1
Stomach	MKN74	8.5
Stomach	MKN7	6.7
Stomach	NCCSTCK140	9.9
Stomach	NCIN87	6
Stomach	NUGC2	6.6
Stomach	NUGC3	5.8
Stomach	NUGC4	9.5
Stomach	OCUM1	5.5
Stomach	RERFGC1B	5.9
Stomach	SH10TC	9.2
Stomach	SNU16	5.5
Stomach	SNU1	5.5
Stomach	SNU216	8.6
Stomach	SNU520	7.1
Stomach	SNU5	7.3
Stomach	SNU601	7.2
Stomach	SNU620	4.9
Stomach	SNU668	9.9
Stomach	SNU719	6.5
Stomach	TGBC11TKB	6.8
Thyroid	8305C	8.3
Thyroid	8505C	10.6
Thyroid	BCPAP	10.6
Thyroid	BHT101	7.4
Thyroid	CAL62	8.3
Thyroid	CGTHW1	7.7
Thyroid	FTC133	7
Thyroid	FTC238	6.6
Thyroid	ML1	10.1
Thyroid	SW579	6.4
Thyroid	TT2609C02	9.2
Thyroid	TT	5.8
Upper aerodigestive tract	BHY	6.5
Upper aerodigestive tract	BICR16	9.4
Upper aerodigestive tract	BICR18	7
Upper aerodigestive tract	BICR22	9.3
Upper aerodigestive tract	BICR31	8.8
Upper aerodigestive tract	BICR56	11
Upper aerodigestive tract	BICR6	9.1
Upper aerodigestive tract	CAL27	7.7
Upper aerodigestive tract	CAL33	6.8
Upper aerodigestive tract	DETROIT562	6.3
Upper aerodigestive tract	FADU	5.2
Upper aerodigestive tract	HS840T	9.2
Upper aerodigestive tract	HSC2	7.2
Upper aerodigestive tract	HSC3	6.9
Upper aerodigestive tract	HSC4	9.1
Upper aerodigestive tract	PECAPJ15	7.5
Upper aerodigestive tract	PECAPJ34CLONEC12	6.9
Upper aerodigestive tract	PECAPJ41CLONED2	8.6
Upper aerodigestive tract	PECAPJ49	7.8
Upper aerodigestive tract	SCC15	9.4
Upper aerodigestive tract	SCC25	8
Upper aerodigestive tract	SCC4	7.3
Upper aerodigestive tract	SCC9	9.2
Upper aerodigestive tract	SNU1076	6.6
Upper aerodigestive tract	SNU1214	8.4
Upper aerodigestive tract	SNU46	8.3
Upper aerodigestive tract	SNU899	8.1
Upper aerodigestive tract	YD10B	6.6
Upper aerodigestive tract	YD38	9
Upper aerodigestive tract	YD8	9.3
Urinary tract	5637	6.8
Urinary tract	639V	9.1
Urinary tract	647V	8.4
Urinary tract	BC3C	7.9
Urinary tract	BFTC905	9.5
Urinary tract	CAL29	9.1
Urinary tract	HS172T	8.3
Urinary tract	HT1197	6.8
Urinary tract	HT1376	8.6
Urinary tract	J82	9.8
Urinary tract	JMSU1	10.8
Urinary tract	KMBC2	6.8
Urinary tract	KU1919	5.1
Urinary tract	RT11284	6.8
Urinary tract	RT112	6.9
Urinary tract	RT4	7.4
Urinary tract	SCABER	5.9
Urinary tract	SW1710	7.6
Urinary tract	SW780	6
Urinary tract	T24	9.6
Urinary tract	TCCSUP	8.4
Urinary tract	UMUC1	7
Urinary tract	UMUC3	8.4
Urinary tract	VMCUB1	5.1

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	770.8
Adrenal gland	683.6
Appendix	523.1
Bone marrow	456.2
Breast	292.7
Cerebral cortex	71.5
Cervix, uterine	778.6
Colon	131.9
Duodenum	68.7
Endometrium	614.9
Epididymis	50
Esophagus	571.4
Fallopian tube	515.7
Gallbladder	901.2
Heart muscle	87.6
Kidney	170.9
Liver	203
Lung	381
Lymph node	206.3
Ovary	555.8
Pancreas	50.6
Parathyroid gland	275.8
Placenta	421.2
Prostate	602.9
Rectum	256.9
Salivary gland	86.8
Seminal vesicle	496.8
Skeletal muscle	20.5
Skin	40.1
Small intestine	150.2
Smooth muscle	641.4
Spleen	321.9
Stomach	128.7
Testis	78.2
Thyroid gland	1020.1
Tonsil	53.2
Urinary bladder	463.1

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
27599524	overexpression	Breast Carcinoma	We detected that MKP-1 overexpression is a recurrent event predominantly linked to dephosphorylation of JNK with an adverse impact on relapse of the tumor and overall and disease-free survival.
27308517	overexpression	Breast Carcinoma	Mitogen-activated protein kinase phosphatase 1 (MKP1 or DUSP1) is an antiapoptotic phosphatase that is overexpressed in many cancers, including breast cancer.
26847061	underexpression	Oral Cavity Squamous Cell Carcinoma	Among 7 transcriptomic markers, transcript level of DUSP1 was significantly lower in OSCC patients than in controls and PMOD patients.
25312268	underexpression	Head and Neck Squamous Cell Carcinoma	In this study, we found DUSP1 mRNA and protein decreased in human head and neck squamous cell carcinoma tissues compared with adjacent nontumor controls.
24382243	overexpression	Pancreatic Carcinoma	Densitometric analysis with normalization to 7S revealed that the median level of MKP-1 mRNA in CP and cancerous tissues was increased by 6.2 folds(P=0.035)and 8.1 folds(P=0.016)in comparison with the median level in the normal pancreatic samples, respectively. Overexpression of MKP-1 was also found in 6 pancreatic cancer cell lines, in which the expression of MKP-1 was slightly lower in one pancreatic cancer cell line but high in the remaining 5 cell lines.
24080497	underexpression; loss of expression	Prostatic Adenocarcinoma	By contrast, DUSP1 expression levels are low or even absent in high-grade prostatic intraepithelial neoplasia and prostatic adenocarcinoma samples, whereas nuclear p65/NF-κB and activated p38 MAPK are highly expressed in the same samples.
23892499	overexpression	Oral Cavity Squamous Cell Carcinoma	Salivary levels of OAZ1, S100P, and DUSP1 mRNAs were significantly higher in newly diagnosed OSCC patients, compared to: (1) normal controls (p=0.003; p=0.003; and p<0.001, respectively); (2) OSCC-in-remission (p<0.001; p=0.001; and p<0.001, respectively); (3) disease-active OLP (p<0.001; p=0.016; and p<0.001, respectively); and (4) disease-inactive OLP (p=0.043; p<0.001; and p<0.001, respectively).
23319273	overexpression	Castration-Resistant Prostate Carcinoma	Studies revealed that the levels of expression of genes responsible for T-cell proliferation (C-FOS, C-JUN and DUSP1) and cellular migration (RGS1) were greater in Tregs from mCRPC patients as compared to values observed in healthy donors.
23169297	underexpression	Prostate Carcinoma	In a panel of 5 benign glands and 15 tumours, we observed concomitant downregulation of the negative regulators SEF and DUSP1 in tumours with increasing Gleason grade.
22547014	underexpression	Breast Carcinoma	We found that total MKP-1 protein levels were decreased in 63.7 % of breast cancer tissues compared with the paired noncancerous breast tissues.
22333693	underexpression	Breast Carcinoma	Our data demonstrate MKP-1 mRNA expression significantly decreased in five breast cancer cell lines compared to breast controls (P<0.01).
21960346	underexpression	Lung Carcinoma	Immunohistochemistry and real-time RT-PCR assay showed that the expression of MKP-1 was gradually decreased as tissue type went from normal lung tissues to increasingly undifferentiated carcinoma, and it was negatively correlated with tumor differentiation (P<0.01).
20682647	overexpression	Melanoma	MKP1 expression was detected in human melanoma cell lines and tissue samples at levels up to six times higher than those in normal or nonmalignant melanocytes.
20234366	overexpression	Colorectal Carcinoma	All patients with BRAF mutations (n=3) had MKP-1 overexpression.
28650468	Overexpression	Cisplatin-resistant Ovarian Carcinoma	Furthermore, we showed that acquired cisplatin-resistant ovarian cancer cells expressed high levels of MKP-1 and PARP-1 proteins, and that silencing MKP-1 or PARP-1 increased cisplatin sensitivity in resistant cells.
27599524	Overexpression	Breast Carcinoma	We detected that MKP-1 overexpression is a recurrent event predominantly linked to dephosphorylation of JNK1/2 with an adverse impact on relapse of the tumor and overall and disease-free survival.

Summary
Symbol	DUSP1
Name	dual specificity phosphatase 1
Aliases	HVH1; CL100; MKP-1; PTPN10; MKP1; CL 100; MAP kinase phosphatase 1; dual specificity protein phosphatase hVH ......
Location	5q35.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.296	1.28e-09	48.3	44.8	6.9	Loss
BRCA	Breast invasive carcinoma	1075	0.186	8.26e-10	19.6	55.9	24.5	Neutral
CESC	Cervical and endocervical cancers	292	0.143	0.0142	23.3	66.8	9.9	Neutral
COAD	Colon adenocarcinoma	449	0.103	0.0284	19.2	72.4	8.5	Neutral
ESCA	Esophageal carcinoma	183	0.153	0.0383	45.9	43.7	10.4	Loss
GBM	Glioblastoma multiforme	147	0.225	0.00615	13.6	78.9	7.5	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.238	4.51e-08	38.5	54.5	7	Loss
KIRC	Kidney renal clear cell carcinoma	525	0.299	2.82e-12	0.8	36.6	62.7	Gain
KIRP	Kidney renal papillary cell carcinoma	288	0.051	0.392	3.8	83.7	12.5	Neutral
LAML	Acute Myeloid Leukemia	166	-0.035	0.658	2.4	97.6	0	Neutral
LGG	Brain Lower Grade Glioma	513	0.043	0.335	11.5	86.4	2.1	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.205	7.95e-05	10.7	51.9	37.4	Gain
LUAD	Lung adenocarcinoma	512	0.244	2.26e-08	32	44.1	23.8	Neutral
LUSC	Lung squamous cell carcinoma	498	0.316	5.41e-13	71.5	23.3	5.2	Loss
OV	Ovarian serous cystadenocarcinoma	300	0.252	9.88e-06	35.7	43.7	20.7	Loss
PAAD	Pancreatic adenocarcinoma	177	0.068	0.366	10.7	76.8	12.4	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.036	0.647	5.6	90.1	4.3	Neutral
PRAD	Prostate adenocarcinoma	491	0.03	0.513	3.3	91.4	5.3	Neutral
READ	Rectum adenocarcinoma	164	-0.013	0.868	28	57.3	14.6	Neutral
SARC	Sarcoma	255	0.191	0.00221	16.1	59.2	24.7	Neutral
SKCM	Skin Cutaneous Melanoma	367	0.129	0.0135	31.6	55.9	12.5	Neutral
STAD	Stomach adenocarcinoma	413	0.222	5.37e-06	29.1	64.2	6.8	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.268	0.000897	64	34	2	Loss
THCA	Thyroid carcinoma	497	0.04	0.375	0	96.2	3.8	Neutral
THYM	Thymoma	119	0.257	0.00483	0.8	91.6	7.6	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.157	0.000255	14.3	78.6	7.1	Neutral

Summary
Symbol	DUSP1
Name	dual specificity phosphatase 1
Aliases	HVH1; CL100; MKP-1; PTPN10; MKP1; CL 100; MAP kinase phosphatase 1; dual specificity protein phosphatase hVH ......
Location	5q35.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.163	0.000758	17	408	0.005	2.58e-07	NS/NA
BRCA	Breast invasive carcinoma	-0.124	0.000258	83	785	0.001	0.7	NS/NA
CESC	Cervical and endocervical cancers	-0.15	0.00847	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.056	0.324	19	297	0.003	0.000111	NS/NA
ESCA	Esophageal carcinoma	-0.12	0.096	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.294	0.0176	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.126	0.00322	20	522	0.002	0.00149	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.148	0.00621	24	319	0.002	0.000125	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.087	0.135	23	275	0.003	0.00229	NS/NA
LAML	Acute Myeloid Leukemia	-0.178	0.0204	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.187	1.49e-05	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.162	0.000949	41	373	0.001	0.671	NS/NA
LUAD	Lung adenocarcinoma	-0.098	0.0329	21	456	0.001	0.54	NS/NA
LUSC	Lung squamous cell carcinoma	-0.193	0.000165	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.633	0.076	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.087	0.242	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.172	0.0186	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.155	0.000337	35	498	0.002	0.154	NS/NA
READ	Rectum adenocarcinoma	-0.12	0.232	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.222	0.000286	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.224	8.98e-07	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.111	0.0328	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.363	3.79e-06	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.071	0.0945	50	509	-0.001	0.248	NS/NA
THYM	Thymoma	-0.226	0.0126	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.072	0.119	34	431	-0.001	0.376	NS/NA

Summary
Symbol	DUSP1
Name	dual specificity phosphatase 1
Aliases	HVH1; CL100; MKP-1; PTPN10; MKP1; CL 100; MAP kinase phosphatase 1; dual specificity protein phosphatase hVH ......
Location	5q35.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	2	Medium
Appendix	3	High
Bone marrow	2	Medium
Breast	2	Medium
Bronchus	3	High
Caudate	2	Medium
Cerebellum	2	Medium
Cerebral cortex	2	Medium
Cervix, uterine	3	High
Colon	3	High
Duodenum	2	Medium
Endometrium	2	Medium
Epididymis	2	Medium
Esophagus	2	Medium
Fallopian tube	2	Medium
Gallbladder	2	Medium
Heart muscle	2	Medium
Hippocampus	2	Medium
Kidney	3	High
Liver	2	Medium
Lung	2	Medium
Lymph node	2	Medium
Nasopharynx	3	High
Oral mucosa	1	Low
Ovary	2	Medium
Pancreas	2	Medium
Parathyroid gland	2	Medium
Placenta	2	Medium
Prostate	2	Medium
Rectum	3	High
Salivary gland	2	Medium
Seminal vesicle	2	Medium
Skeletal muscle	2	Medium
Skin	2	Medium
Small intestine	2	Medium
Smooth muscle	1	Low
Soft tissue	2	Medium
Spleen	2	Medium
Stomach	2	Medium
Testis	2	Medium
Thyroid gland	2	Medium
Tonsil	2	Medium
Urinary bladder	2	Medium
Vagina	1	Low

Summary
Symbol	DUSP1
Name	dual specificity phosphatase 1
Aliases	HVH1; CL100; MKP-1; PTPN10; MKP1; CL 100; MAP kinase phosphatase 1; dual specificity protein phosphatase hVH ......
Location	5q35.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.91	NS	24476821
BRCA	Breast invasive carcinoma	521	5.05e-13	Significant	23000897
COAD	Colon adenocarcinoma	149	1.58e-05	Significant	22810696
GBM	Glioblastoma multiforme	157	3.88e-05	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	0.0134	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.322	NS	26536169
LGG	Brain Lower Grade Glioma	513	0.00341	Significant	26824661
LUAD	Lung adenocarcinoma	230	0.00663	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	1.97e-05	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	1.99e-09	Significant	21720365
PRAD	Prostate adenocarcinoma	333	0.0458	Significant	26544944
READ	Rectum adenocarcinoma	67	0.0108	Significant	22810696
SKCM	Skin Cutaneous Melanoma	315	0.199	NS	26091043
STAD	Stomach adenocarcinoma	277	1.91e-07	Significant	25079317
THCA	Thyroid carcinoma	391	0.00229	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.764	NS	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	1.296	0.218	NS
BRCA	Breast invasive carcinoma	1079	0.942	0.799	NS
CESC	Cervical and endocervical cancers	291	0.76	0.423	NS
COAD	Colon adenocarcinoma	439	0.803	0.483	NS
ESCA	Esophageal carcinoma	184	2.334	0.00817	Shorter
GBM	Glioblastoma multiforme	158	1.006	0.986	NS
HNSC	Head and Neck squamous cell carcinoma	518	0.759	0.132	NS
KIRC	Kidney renal clear cell carcinoma	531	0.717	0.128	NS
KIRP	Kidney renal papillary cell carcinoma	287	0.774	0.536	NS
LAML	Acute Myeloid Leukemia	149	0.92	0.761	NS
LGG	Brain Lower Grade Glioma	511	1.42	0.195	NS
LIHC	Liver hepatocellular carcinoma	365	0.572	0.0201	Longer
LUAD	Lung adenocarcinoma	502	1.021	0.924	NS
LUSC	Lung squamous cell carcinoma	494	1.553	0.0201	Shorter
OV	Ovarian serous cystadenocarcinoma	303	1.095	0.662	NS
PAAD	Pancreatic adenocarcinoma	177	1.274	0.416	NS
PCPG	Pheochromocytoma and Paraganglioma	179	0	0.0882	NS
PRAD	Prostate adenocarcinoma	497	0.485	0.324	NS
READ	Rectum adenocarcinoma	159	0.955	0.934	NS
SARC	Sarcoma	259	0.653	0.118	NS
SKCM	Skin Cutaneous Melanoma	459	0.832	0.335	NS
STAD	Stomach adenocarcinoma	388	1.805	0.0091	Shorter
TGCT	Testicular Germ Cell Tumors	134	1.491	0.745	NS
THCA	Thyroid carcinoma	500	2.477	0.247	NS
THYM	Thymoma	119	2805128479.47	0.00614	Shorter
UCEC	Uterine Corpus Endometrial Carcinoma	543	1.258	0.439	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	0.116	0.0197	Higher
BRCA	Breast invasive carcinoma	1071	-0.017	0.585	NS
CESC	Cervical and endocervical cancers	167	-0.195	0.0116	Lower
COAD	Colon adenocarcinoma	445	-0.026	0.591	NS
ESCA	Esophageal carcinoma	162	0.069	0.384	NS
HNSC	Head and Neck squamous cell carcinoma	448	0.004	0.93	NS
KIRC	Kidney renal clear cell carcinoma	531	-0.056	0.197	NS
KIRP	Kidney renal papillary cell carcinoma	260	-0.086	0.165	NS
LIHC	Liver hepatocellular carcinoma	347	-0.108	0.0451	Lower
LUAD	Lung adenocarcinoma	507	-0.006	0.898	NS
LUSC	Lung squamous cell carcinoma	497	-0.05	0.264	NS
OV	Ovarian serous cystadenocarcinoma	302	0.105	0.0676	NS
PAAD	Pancreatic adenocarcinoma	176	0.071	0.349	NS
READ	Rectum adenocarcinoma	156	-0.102	0.207	NS
SKCM	Skin Cutaneous Melanoma	410	0.056	0.258	NS
STAD	Stomach adenocarcinoma	392	0.061	0.227	NS
TGCT	Testicular Germ Cell Tumors	81	0.278	0.0119	Higher
THCA	Thyroid carcinoma	499	-0.049	0.271	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.01	0.817	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	-0.061	0.319	NS
HNSC	Head and Neck squamous cell carcinoma	498	-0.156	0.000458	Lower
KIRC	Kidney renal clear cell carcinoma	525	-0.1	0.0217	Lower
LGG	Brain Lower Grade Glioma	514	0.119	0.00713	Higher
LIHC	Liver hepatocellular carcinoma	366	-0.177	0.000678	Lower
OV	Ovarian serous cystadenocarcinoma	296	-0.064	0.274	NS
PAAD	Pancreatic adenocarcinoma	176	0.057	0.452	NS
STAD	Stomach adenocarcinoma	406	0.069	0.163	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	-0.103	0.017	Lower

Summary
Symbol	DUSP1
Name	dual specificity phosphatase 1
Aliases	HVH1; CL100; MKP-1; PTPN10; MKP1; CL 100; MAP kinase phosphatase 1; dual specificity protein phosphatase hVH ......
Location	5q35.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	DUSP1
Name	dual specificity phosphatase 1
Aliases	HVH1; CL100; MKP-1; PTPN10; MKP1; CL 100; MAP kinase phosphatase 1; dual specificity protein phosphatase hVH ......
Location	5q35.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for DUSP1.

Summary
Symbol	DUSP1
Name	dual specificity phosphatase 1
Aliases	HVH1; CL100; MKP-1; PTPN10; MKP1; CL 100; MAP kinase phosphatase 1; dual specificity protein phosphatase hVH ......
Location	5q35.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
20234366	Colorectal Carcinoma	partner	BRAF	correlation	All patients with BRAF mutations (n=3) had MKP-1 overexpression.
27599524	Breast Carcinoma	partner	dephosphorylation of JNK1/2	Association	We detected that MKP-1 overexpression is a recurrent event predominantly linked to dephosphorylation of JNK1/2 with an adverse impact on relapse of the tumor and overall and disease-free survival.