Browse EPC2 in pancancer

Summary
SymbolEPC2
Nameenhancer of polycomb homolog 2
Aliases DKFZP566F2124; EPC-LIKE; Enhancer of polycomb homolog 2
Location2q23.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Domain, Function and Classification
> Gene Ontology
> KEGG and Reactome Pathway
> Domain, Function and Classification
 
Domain PF06752 Enhancer of Polycomb C-terminus
PF10513 Enhancer of polycomb-like
Function

May play a role in transcription or DNA repair.

Classification
Class Modification Substrate Product PubMed
Chromatin remodelling # # # 19898529
> Gene Ontology
 
Biological Process GO:0006473 protein acetylation
GO:0006475 internal protein amino acid acetylation
GO:0016570 histone modification
GO:0016573 histone acetylation
GO:0018205 peptidyl-lysine modification
GO:0018393 internal peptidyl-lysine acetylation
GO:0018394 peptidyl-lysine acetylation
GO:0043543 protein acylation
Molecular Function GO:0004402 histone acetyltransferase activity
GO:0008080 N-acetyltransferase activity
GO:0016407 acetyltransferase activity
GO:0016410 N-acyltransferase activity
GO:0016746 transferase activity, transferring acyl groups
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups
GO:0034212 peptide N-acetyltransferase activity
GO:0061733 peptide-lysine-N-acetyltransferase activity
Cellular Component GO:0000123 histone acetyltransferase complex
GO:0031248 protein acetyltransferase complex
GO:0032777 Piccolo NuA4 histone acetyltransferase complex
GO:0035267 NuA4 histone acetyltransferase complex
GO:0043189 H4/H2A histone acetyltransferase complex
GO:1902493 acetyltransferase complex
GO:1902562 H4 histone acetyltransferase complex
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolEPC2
Nameenhancer of polycomb homolog 2
Aliases DKFZP566F2124; EPC-LIKE; Enhancer of polycomb homolog 2
Location2q23.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Mutation landscape in primary tumor tissue from TCGA
> Mutation landscape in cancer cell line from CCLE
> All mutations from COSMIC database V81
> Variations from text mining
> The Cancer Genome Atlas (TCGA)
 
> Cancer Cell Line Encyclopedia (CCLE)
 
There is no record.
> Catalogue of Somatic Mutations in Cancer (COSMIC)
 
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COSMIC ID
CDS change
AA change
Mutation Type
Anatomical Site
COSM1157868c.1496G>Ap.R499QSubstitution - MissensePancreas
COSM3296276c.1208G>Ap.R403QSubstitution - MissenseLarge_intestine
COSM3296244c.45G>Ap.K15KSubstitution - coding silentUpper_aerodigestive_tract
COSM5500684c.300C>Tp.F100FSubstitution - coding silentBiliary_tract
COSM1399854c.200delAp.E70fs*39Deletion - FrameshiftLarge_intestine
COSM1205424c.2195A>Gp.H732RSubstitution - MissenseLarge_intestine
COSM3296312c.2184A>Cp.T728TSubstitution - coding silentUpper_aerodigestive_tract
COSM5791484c.233A>Cp.E78ASubstitution - MissenseBreast
COSM1399864c.2246G>Ap.R749QSubstitution - MissenseLarge_intestine
COSM5343779c.877A>Gp.K293ESubstitution - MissenseLarge_intestine
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> Text Mining based Variations
 
There is no record for EPC2.
Summary
SymbolEPC2
Nameenhancer of polycomb homolog 2
Aliases DKFZP566F2124; EPC-LIKE; Enhancer of polycomb homolog 2
Location2q23.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Post-translational modification (PTM)
> Post-translational modification (PTM)
 
 Filter By:
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Uniprot ID
Position
Amino Acid
Description
Upstream Enzyme
Amino Acid Sequence Variant
Q52LR7754SPhosphoserine-p.S754L (cancer: SKCM, STAD)
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Summary
SymbolEPC2
Nameenhancer of polycomb homolog 2
Aliases DKFZP566F2124; EPC-LIKE; Enhancer of polycomb homolog 2
Location2q23.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Expression analysis in primary tumor tissue from TCGA
> Expression level in cancer cell line from CCLE
> Expression level in human normal tissue from HPA
> Text mining based expression change
> The Cancer Genome Atlas (TCGA)
 


  Differential expression analysis for cancers with more than 10 normal samples
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Cancer
Full Name
# N
# T
Median (N)
Median (T)
LogFC
Adj. P
Status
BLCABladder urothelial carcinoma194084.9564.34-0.5250.000305NS
BRCABreast invasive carcinoma11211005.5114.959-0.5373.29e-23NS
CESCCervical and endocervical cancers33065.3854.558NANANA
COADColon adenocarcinoma414594.6694.538-0.1520.0273NS
ESCAEsophageal carcinoma111854.6234.759-0.0610.752NS
GBMGlioblastoma multiforme51665.3915.25NANANA
HNSCHead and Neck squamous cell carcinoma445224.3474.257-0.1790.0627NS
KIRCKidney renal clear cell carcinoma725344.9594.983-0.0210.737NS
KIRPKidney renal papillary cell carcinoma322914.6474.391-0.3010.00754NS
LAMLAcute Myeloid Leukemia0173NA5.846NANANA
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> Cancer Cell Line Encyclopedia (CCLE)
 



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Tissue
Cell Line
Expression Level (Microarray)
Autonomic gangliaCHP1269.3
Autonomic gangliaCHP2128.5
Autonomic gangliaIMR328.8
Autonomic gangliaKELLY7.8
Autonomic gangliaKPNRTBM18.8
Autonomic gangliaKPNSI9S8.3
Autonomic gangliaKPNYN9
Autonomic gangliaMHHNB117.6
Autonomic gangliaNB17.9
Autonomic gangliaNH69.1
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> The Human Protein Atlas (HPA)
 


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Tissue
Expression Level (TPM)
Adipose tissue19.2
Adrenal gland19.4
Appendix19.8
Bone marrow31.9
Breast22.2
Cerebral cortex27
Cervix, uterine28.3
Colon12.8
Duodenum10.5
Endometrium44
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> Text Mining based Expression
 
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PMID
Expression
Cancer
Evidence
25230976UnderexpressionClear Cell Renal Cell CarcinomaQuantitative RT-PCR analysis revealed that the mRNA expression levels for the MMACHC, PTER, EPC2, ATXN7, FHIT, KIFAP3, CPEB1, MINPP1, TEX264, FAM107A, UPF3A, CDC16, MCCC1, CPSF3, and ASAP2 genes, being partner genes involved in the chimeric transcripts in the initial cohort, were significantly reduced in 26 T samples relative to the corresponding 26 N samples in the second cohort.
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Summary
SymbolEPC2
Nameenhancer of polycomb homolog 2
Aliases DKFZP566F2124; EPC-LIKE; Enhancer of polycomb homolog 2
Location2q23.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Somatic copy number alteration in primary tomur tissue
> The Cancer Genome Atlas (TCGA)
 


  Correlation between expression and SCNA as well as percentage of patients in different status.
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Cancer
Full Name
# Sample
R
P
% Loss
% Neutral
% Gain
Status
BLCABladder urothelial carcinoma4040.3411.83e-122860.411.6Neutral
BRCABreast invasive carcinoma10750.2622.65e-182468.27.8Neutral
CESCCervical and endocervical cancers2920.3971.81e-1215.871.912.3Neutral
COADColon adenocarcinoma4490.4027.64e-194.57817.6Neutral
ESCAEsophageal carcinoma1830.543.24e-1513.75927.3Neutral
GBMGlioblastoma multiforme1470.230.005036.187.16.8Neutral
HNSCHead and Neck squamous cell carcinoma5140.2883.06e-119.974.515.6Neutral
KIRCKidney renal clear cell carcinoma5250.2364.62e-082.782.115.2Neutral
KIRPKidney renal papillary cell carcinoma2880.1430.01532.181.616.3Neutral
LAMLAcute Myeloid Leukemia1660.1180.13101000Neutral
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Summary
SymbolEPC2
Nameenhancer of polycomb homolog 2
Aliases DKFZP566F2124; EPC-LIKE; Enhancer of polycomb homolog 2
Location2q23.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Methylation level in the promoter region of CR
> Methylation level in the promoter region of CR
 


  Correlation between expression and methylation as well as differential methylation analysis.
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Cancer
Full Name
R
P
# N
# T
Delta beta (T vs N)
P value (T vs N)
Status
BLCABladder urothelial carcinoma-0.2551.05e-07174080.0220.0113NS/NA
BRCABreast invasive carcinoma-0.3250837850.0021.35e-05NS/NA
CESCCervical and endocervical cancers-0.20.0004263306NANANS/NA
COADColon adenocarcinoma-0.1470.0087519297-0.0150.0739NS/NA
ESCAEsophageal carcinoma-0.2430.0006749185NANANS/NA
GBMGlioblastoma multiforme-0.1770.158164NANANS/NA
HNSCHead and Neck squamous cell carcinoma-0.2943.61e-12205220.0020.0138NS/NA
KIRCKidney renal clear cell carcinoma-0.1260.0199243190.0060.0241NS/NA
KIRPKidney renal papillary cell carcinoma-0.2894.53e-07232750.020.000723NS/NA
LAMLAcute Myeloid Leukemia-0.1280.09720170NANANS/NA
Showing 1 to 10 of 26 rows rows per page
Summary
SymbolEPC2
Nameenhancer of polycomb homolog 2
Aliases DKFZP566F2124; EPC-LIKE; Enhancer of polycomb homolog 2
Location2q23.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Primary tumor tissue from TCGA
> Normal tumor tissue from HPA
>The Cancer Genome Atlas (TCGA)
 
There is no record.
> The Human Protein Atlas (HPA)
 


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Tissue
Level
Level Name
Adrenal gland3High
Appendix2Medium
Bone marrow3High
Breast2Medium
Bronchus2Medium
Caudate2Medium
Cerebellum2Medium
Cerebral cortex2Medium
Cervix, uterine3High
Colon3High
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Summary
SymbolEPC2
Nameenhancer of polycomb homolog 2
Aliases DKFZP566F2124; EPC-LIKE; Enhancer of polycomb homolog 2
Location2q23.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Association between expresson and subtype
> Overall survival analysis based on expression
> Association between expresson and stage
> Association between expresson and grade
> Subtype
 


  Association between expresson and subtype.
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Cancer
Full Name
# Patients
P Value (Kruskal-Wallis)
Association
Source
BLCABladder urothelial carcinoma1280.45NS24476821
BRCABreast invasive carcinoma5217.12e-08Significant23000897
COADColon adenocarcinoma1490.11NS22810696
GBMGlioblastoma multiforme1570.00605Significant26824661
HNSCHead and Neck squamous cell carcinoma2794.5e-08Significant25631445
KIRPKidney renal papillary cell carcinoma1610.392NS26536169
LGGBrain Lower Grade Glioma5139.22e-17Significant26824661
LUADLung adenocarcinoma2300.0112Significant25079552
LUSCLung squamous cell carcinoma1780.00412Significant22960745
OVOvarian serous cystadenocarcinoma2870.00378Significant21720365
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> Overall survival
 

  Overall survival analysis based on expression.
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Cancer
Full Name
# Patients
Hazard Ratio
P Value (Log Rank Test)
Association
BLCABladder urothelial carcinoma405 0.9140.664NS
BRCABreast invasive carcinoma1079 1.0360.872NS
CESCCervical and endocervical cancers291 1.8260.0916NS
COADColon adenocarcinoma439 1.5080.132NS
ESCAEsophageal carcinoma184 0.970.919NS
GBMGlioblastoma multiforme158 0.4660.00387Longer
HNSCHead and Neck squamous cell carcinoma518 0.6740.0547NS
KIRCKidney renal clear cell carcinoma531 0.3635.55e-06Longer
KIRPKidney renal papillary cell carcinoma287 2.5420.0427Shorter
LAMLAcute Myeloid Leukemia149 0.7830.405NS
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> Stage
 

  Association between expresson and stage.
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Cancer
Full Name
# Patients
R Value (Spearman)
P Value (Spearman)
Association
BLCABladder urothelial carcinoma406 -0.0510.304NS
BRCABreast invasive carcinoma1071 -0.0740.0156Lower
CESCCervical and endocervical cancers167 -0.1050.178NS
COADColon adenocarcinoma445 0.0270.571NS
ESCAEsophageal carcinoma162 -0.0230.775NS
HNSCHead and Neck squamous cell carcinoma448 -0.090.058NS
KIRCKidney renal clear cell carcinoma531 -0.2071.48e-06Lower
KIRPKidney renal papillary cell carcinoma260 0.0790.207NS
LIHCLiver hepatocellular carcinoma347 0.0860.111NS
LUADLung adenocarcinoma507 0.0030.941NS
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> Grade
 

  Association between expresson and grade.
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Cancer
Full Name
# Patients
R Value (Spearman)
P Value (Spearman)
Association
CESCCervical and endocervical cancers272 0.050.415NS
HNSCHead and Neck squamous cell carcinoma498 0.0790.0779NS
KIRCKidney renal clear cell carcinoma525 -0.2383.43e-08Lower
LGGBrain Lower Grade Glioma514 0.0090.841NS
LIHCLiver hepatocellular carcinoma366 -0.030.565NS
OVOvarian serous cystadenocarcinoma296 -0.080.169NS
PAADPancreatic adenocarcinoma176 -0.1410.0623NS
STADStomach adenocarcinoma406 0.0190.707NS
UCECUterine Corpus Endometrial Carcinoma534 0.1250.00389Higher
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Summary
SymbolEPC2
Nameenhancer of polycomb homolog 2
Aliases DKFZP566F2124; EPC-LIKE; Enhancer of polycomb homolog 2
Location2q23.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Targets inferred by reverse engineering method
> Targets identified by ChIP-seq data
> Targets inferred by reverse engineering method
 
> Targets identified by ChIP-seq data
 
Summary
SymbolEPC2
Nameenhancer of polycomb homolog 2
Aliases DKFZP566F2124; EPC-LIKE; Enhancer of polycomb homolog 2
Location2q23.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Drugs from DrugBank database
> Drugs from DrugBank database
 
There is no record for EPC2.
Summary
SymbolEPC2
Nameenhancer of polycomb homolog 2
Aliases DKFZP566F2124; EPC-LIKE; Enhancer of polycomb homolog 2
Location2q23.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Protein-Protein Interaction Network
> miRNA Regulatory Relationship
> Interactions from Text Mining
> Protein-Protein Interaction Network
 
> miRNA Regulatory Relationship
 
> Interactions from Text Mining
 
There is no record for EPC2.