CR2Cancer

Summary
Symbol	EYA2
Name	EYA transcriptional coactivator and phosphatase 2
Aliases	EAB1; eyes absent (Drosophila) homolog 2; eyes absent homolog 2 (Drosophila); Eyes absent homolog 2
Location	20q13.12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

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Domain

Function

Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5 (PubMed:12500905, PubMed:23435380). Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19351884). Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2; in this it is functionally redundant with EYA1 (PubMed:12500905).

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification erase	Histone phosphorylation	H2AXT142	#	19351884

> Gene Ontology [ TOP ]
Biological Process	GO:0001704 formation of primary germ layer GO:0001707 mesoderm formation GO:0001708 cell fate specification GO:0001710 mesodermal cell fate commitment GO:0006282 regulation of DNA repair GO:0006470 protein dephosphorylation GO:0006839 mitochondrial transport GO:0007006 mitochondrial membrane organization GO:0007369 gastrulation GO:0007498 mesoderm development GO:0007501 mesodermal cell fate specification GO:0008637 apoptotic mitochondrial changes GO:0014706 striated muscle tissue development GO:0016311 dephosphorylation GO:0016570 histone modification GO:0016576 histone dephosphorylation GO:0035335 peptidyl-tyrosine dephosphorylation GO:0035794 positive regulation of mitochondrial membrane permeability GO:0038034 signal transduction in absence of ligand GO:0045165 cell fate commitment GO:0045739 positive regulation of DNA repair GO:0046902 regulation of mitochondrial membrane permeability GO:0048332 mesoderm morphogenesis GO:0048333 mesodermal cell differentiation GO:0051052 regulation of DNA metabolic process GO:0051054 positive regulation of DNA metabolic process GO:0060537 muscle tissue development GO:0060795 cell fate commitment involved in formation of primary germ layer GO:0090559 regulation of membrane permeability GO:0097191 extrinsic apoptotic signaling pathway GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand GO:0097345 mitochondrial outer membrane permeabilization GO:1901099 negative regulation of signal transduction in absence of ligand GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process GO:1902110 positive regulation of mitochondrial membrane permeability involved in apoptotic process GO:1902686 mitochondrial outer membrane permeabilization involved in programmed cell death GO:2001020 regulation of response to DNA damage stimulus GO:2001022 positive regulation of response to DNA damage stimulus GO:2001233 regulation of apoptotic signaling pathway GO:2001234 negative regulation of apoptotic signaling pathway GO:2001236 regulation of extrinsic apoptotic signaling pathway GO:2001237 negative regulation of extrinsic apoptotic signaling pathway GO:2001239 regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
Molecular Function	GO:0000287 magnesium ion binding GO:0004721 phosphoprotein phosphatase activity GO:0004725 protein tyrosine phosphatase activity GO:0016791 phosphatase activity GO:0042578 phosphoric ester hydrolase activity
Cellular Component	-

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-5693606: DNA Double Strand Break Response R-HSA-5693532: DNA Double-Strand Break Repair R-HSA-73894: DNA Repair R-HSA-5693565: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks

Summary
Symbol	EYA2
Name	EYA transcriptional coactivator and phosphatase 2
Aliases	EAB1; eyes absent (Drosophila) homolog 2; eyes absent homolog 2 (Drosophila); Eyes absent homolog 2
Location	20q13.12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM3911509	c.174C>T	p.L58L	Substitution - coding silent	Skin
COSM4854578	c.150C>G	p.F50L	Substitution - Missense	Cervix
COSM4630594	c.722C>A	p.P241Q	Substitution - Missense	Large_intestine
COSM393982	c.290C>T	p.P97L	Substitution - Missense	Lung
COSM3911511	c.741G>A	p.G247G	Substitution - coding silent	Large_intestine
COSM1718784	c.762G>A	p.K254K	Substitution - coding silent	Skin
COSM3547337	c.847C>T	p.H283Y	Substitution - Missense	Skin
COSM3547343	c.1305C>T	p.I435I	Substitution - coding silent	Skin
COSM3693547	c.1473C>T	p.F491F	Substitution - coding silent	Large_intestine
COSM1251618	c.703G>C	p.E235Q	Substitution - Missense	Oesophagus
COSM3547328	c.293C>T	p.S98F	Substitution - Missense	Skin
COSM3547344	c.1402C>T	p.P468S	Substitution - Missense	Skin
COSM375736	c.136G>T	p.V46L	Substitution - Missense	Lung
COSM1027506	c.908G>A	p.R303H	Substitution - Missense	Stomach
COSM275028	c.844T>G	p.F282V	Substitution - Missense	Large_intestine
COSM3764885	c.483G>T	p.Q161H	Substitution - Missense	Central_nervous_system
COSM137213	c.377C>T	p.S126L	Substitution - Missense	Skin
COSM1027504	c.860C>T	p.T287M	Substitution - Missense	Endometrium
COSM5392252	c.213G>A	p.Q71Q	Substitution - coding silent	Skin
COSM4595343	c.931_938delATGATCTT	p.M311fs*11	Deletion - Frameshift	Upper_aerodigestive_tract
COSM3701634	c.1400T>C	p.F467S	Substitution - Missense	Liver
COSM3707810	c.832A>T	p.T278S	Substitution - Missense	Liver
COSM4520903	c.1082G>A	p.G361E	Substitution - Missense	Skin
COSM3547329	c.330C>T	p.S110S	Substitution - coding silent	Skin
COSM1190276	c.247C>T	p.P83S	Substitution - Missense	Lung
COSM4911456	c.624T>C	p.S208S	Substitution - coding silent	Liver
COSM3294807	c.1529C>T	p.A510V	Substitution - Missense	Stomach
COSM3547330	c.416-1G>A	p.?	Unknown	Skin
COSM301033	c.463G>A	p.G155S	Substitution - Missense	Large_intestine
COSM4134606	c.1160T>G	p.V387G	Substitution - Missense	Upper_aerodigestive_tract
COSM5449430	c.1554G>A	p.W518*	Substitution - Nonsense	Large_intestine
COSM4441486	c.631G>A	p.V211I	Substitution - Missense	Large_intestine
COSM1412224	c.1107C>T	p.G369G	Substitution - coding silent	Large_intestine
COSM443947	c.1110G>A	p.V370V	Substitution - coding silent	Breast
COSM370063	c.563C>A	p.P188Q	Substitution - Missense	Lung
COSM5824033	c.1336G>T	p.V446F	Substitution - Missense	Liver
COSM5663759	c.227C>A	p.A76E	Substitution - Missense	Soft_tissue
COSM1027507	c.959T>C	p.L320P	Substitution - Missense	Endometrium
COSM1027504	c.860C>T	p.T287M	Substitution - Missense	Kidney
COSM3547332	c.524C>T	p.P175L	Substitution - Missense	Skin
COSM1740684	c.933G>T	p.M311I	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1718784	c.762G>A	p.K254K	Substitution - coding silent	Skin
COSM3547340	c.1122G>A	p.V374V	Substitution - coding silent	Skin
COSM4596741	c.896C>A	p.T299K	Substitution - Missense	Upper_aerodigestive_tract
COSM5914285	c.924G>A	p.M308I	Substitution - Missense	Skin
COSM3294775	c.755G>A	p.R252Q	Substitution - Missense	Prostate
COSM3911509	c.174C>T	p.L58L	Substitution - coding silent	Skin
COSM3547332	c.524C>T	p.P175L	Substitution - Missense	Liver
COSM1713594	c.500C>T	p.P167L	Substitution - Missense	Skin
COSM3294757	c.78C>T	p.D26D	Substitution - coding silent	Cervix
COSM4501471	c.589C>T	p.L197F	Substitution - Missense	Skin
COSM380169	c.1114G>C	p.G372R	Substitution - Missense	Lung
COSM1681736	c.893C>T	p.T298I	Substitution - Missense	Large_intestine
COSM1713597	c.761A>G	p.K254R	Substitution - Missense	Skin
COSM4134605	c.264A>C	p.P88P	Substitution - coding silent	Thyroid
COSM232276	c.584C>T	p.S195L	Substitution - Missense	Skin
COSM4979237	c.547A>T	p.N183Y	Substitution - Missense	Oesophagus
COSM5699862	c.313G>C	p.D105H	Substitution - Missense	Soft_tissue
COSM3707810	c.832A>T	p.T278S	Substitution - Missense	Liver
COSM1027504	c.860C>T	p.T287M	Substitution - Missense	Large_intestine
COSM5392255	c.567C>T	p.A189A	Substitution - coding silent	Skin
COSM5818467	c.1205T>A	p.I402K	Substitution - Missense	Liver
COSM1307479	c.156-1G>C	p.?	Unknown	Urinary_tract
COSM1027502	c.196A>G	p.M66V	Substitution - Missense	Endometrium
COSM79811	c.810G>C	p.V270V	Substitution - coding silent	Ovary
COSM3547331	c.437G>A	p.G146E	Substitution - Missense	Skin
COSM4548387	c.445G>A	p.G149R	Substitution - Missense	Skin
COSM1412226	c.1113C>T	p.H371H	Substitution - coding silent	Large_intestine
COSM1412228	c.1602G>C	p.E534D	Substitution - Missense	Large_intestine
COSM3547333	c.648C>T	p.S216S	Substitution - coding silent	Skin
COSM3547341	c.1201T>C	p.L401L	Substitution - coding silent	Skin
COSM5759123	c.1060G>C	p.G354R	Substitution - Missense	Bone
COSM1027506	c.908G>A	p.R303H	Substitution - Missense	Endometrium
COSM1130619	c.1022A>C	p.N341T	Substitution - Missense	Prostate
COSM1205879	c.749G>A	p.R250Q	Substitution - Missense	Large_intestine
COSM4136940	c.785C>T	p.A262V	Substitution - Missense	Ovary
COSM4134606	c.1160T>G	p.V387G	Substitution - Missense	Upper_aerodigestive_tract
COSM5730162	c.396_397insTACACC	p.Y135_Q136insTY	Insertion - In frame	Skin
COSM1713596	c.715G>A	p.D239N	Substitution - Missense	Skin
COSM4881625	c.814G>A	p.V272M	Substitution - Missense	Upper_aerodigestive_tract
COSM1713595	c.683G>A	p.G228E	Substitution - Missense	Skin
COSM255944	c.597G>A	p.T199T	Substitution - coding silent	Central_nervous_system
COSM5471221	c.1156C>T	p.R386W	Substitution - Missense	Large_intestine
COSM3294780	c.813C>T	p.F271F	Substitution - coding silent	Skin
COSM232276	c.584C>T	p.S195L	Substitution - Missense	Skin
COSM1713598	c.921G>A	p.M307I	Substitution - Missense	Skin
COSM1027509	c.1050C>A	p.F350L	Substitution - Missense	Endometrium
COSM724364	c.1128G>T	p.W376C	Substitution - Missense	Lung
COSM1713595	c.683G>A	p.G228E	Substitution - Missense	Skin
COSM4898234	c.876C>T	p.S292S	Substitution - coding silent	Pancreas
COSM3547328	c.293C>T	p.S98F	Substitution - Missense	Skin
COSM1713595	c.683G>A	p.G228E	Substitution - Missense	Skin
COSM4099053	c.513G>T	p.Q171H	Substitution - Missense	Stomach
COSM1713601	c.1153C>T	p.R385W	Substitution - Missense	Skin
COSM1713598	c.921G>A	p.M307I	Substitution - Missense	Skin
COSM1713595	c.683G>A	p.G228E	Substitution - Missense	Skin
COSM3547329	c.330C>T	p.S110S	Substitution - coding silent	Skin
COSM4099052	c.75T>C	p.A25A	Substitution - coding silent	Stomach
COSM403402	c.144G>T	p.Q48H	Substitution - Missense	Lung
COSM5642245	c.796G>C	p.E266Q	Substitution - Missense	Oesophagus
COSM3547332	c.524C>T	p.P175L	Substitution - Missense	Liver
COSM4099054	c.585G>A	p.S195S	Substitution - coding silent	Stomach
COSM1681736	c.893C>T	p.T298I	Substitution - Missense	Large_intestine
COSM4544884	c.365G>A	p.S122N	Substitution - Missense	Skin
COSM4134607	c.1593C>T	p.H531H	Substitution - coding silent	Thyroid
COSM2149757	c.1458G>C	p.R486S	Substitution - Missense	Central_nervous_system
COSM3911511	c.741G>A	p.G247G	Substitution - coding silent	Skin
COSM5927066	c.1513G>A	p.E505K	Substitution - Missense	Skin
COSM3758609	c.738C>T	p.D246D	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM1713599	c.941A>G	p.N314S	Substitution - Missense	Skin
COSM1027505	c.883G>A	p.G295R	Substitution - Missense	Endometrium
COSM4134606	c.1160T>G	p.V387G	Substitution - Missense	Upper_aerodigestive_tract
COSM3758609	c.738C>T	p.D246D	Substitution - coding silent	Thyroid
COSM1205879	c.749G>A	p.R250Q	Substitution - Missense	Prostate
COSM1027506	c.908G>A	p.R303H	Substitution - Missense	Stomach
COSM1412225	c.1108G>A	p.V370M	Substitution - Missense	Large_intestine
COSM4401723	c.1283C>T	p.S428F	Substitution - Missense	Skin
COSM3294793	c.1058A>G	p.D353G	Substitution - Missense	Large_intestine
COSM232276	c.584C>T	p.S195L	Substitution - Missense	Stomach
COSM6004416	c.662-5G>A	p.?	Unknown	Prostate
COSM4520903	c.1082G>A	p.G361E	Substitution - Missense	Skin
COSM345142	c.826G>A	p.D276N	Substitution - Missense	Lung
COSM5718116	c.491C>T	p.P164L	Substitution - Missense	Skin
COSM1412227	c.1116C>T	p.G372G	Substitution - coding silent	Large_intestine
COSM1412225	c.1108G>A	p.V370M	Substitution - Missense	Liver
COSM3294808	c.1530G>A	p.A510A	Substitution - coding silent	Skin
COSM478239	c.722C>T	p.P241L	Substitution - Missense	Kidney
COSM3911511	c.741G>A	p.G247G	Substitution - coding silent	Skin
COSM255944	c.597G>A	p.T199T	Substitution - coding silent	Central_nervous_system
COSM5673666	c.400_415+6del22	p.?	Unknown	Soft_tissue
COSM1483708	c.645T>C	p.S215S	Substitution - coding silent	Breast
COSM3911509	c.174C>T	p.L58L	Substitution - coding silent	Skin
COSM5974079	c.537C>T	p.G179G	Substitution - coding silent	Upper_aerodigestive_tract
COSM1713592	c.4G>A	p.V2I	Substitution - Missense	Skin
COSM478238	c.580C>A	p.P194T	Substitution - Missense	Kidney
COSM3547342	c.1258C>T	p.L420F	Substitution - Missense	Skin
COSM5798469	c.1443G>C	p.E481D	Substitution - Missense	Breast
COSM5392253	c.437G>T	p.G146V	Substitution - Missense	Skin
COSM4754223	c.935T>C	p.I312T	Substitution - Missense	Stomach
COSM5057372	c.1491C>T	p.Y497Y	Substitution - coding silent	Stomach
COSM5916821	c.706G>A	p.G236R	Substitution - Missense	Skin
COSM1027508	c.1034T>G	p.L345*	Substitution - Nonsense	Endometrium
COSM3547339	c.1077C>T	p.A359A	Substitution - coding silent	Skin
COSM4898234	c.876C>T	p.S292S	Substitution - coding silent	Skin
COSM4682129	c.1182C>T	p.Y394Y	Substitution - coding silent	Large_intestine
COSM4878684	c.166C>T	p.R56C	Substitution - Missense	Prostate
COSM1027505	c.883G>A	p.G295R	Substitution - Missense	Skin
COSM724365	c.509C>A	p.P170H	Substitution - Missense	Lung
COSM5712949	c.1104T>A	p.S368S	Substitution - coding silent	Central_nervous_system
COSM1713600	c.1003G>A	p.D335N	Substitution - Missense	Skin
COSM228231	c.52G>A	p.D18N	Substitution - Missense	Skin
COSM260731	c.156A>G	p.R52R	Substitution - coding silent	Large_intestine
COSM1205879	c.749G>A	p.R250Q	Substitution - Missense	Prostate
COSM3547332	c.524C>T	p.P175L	Substitution - Missense	Skin
COSM1681736	c.893C>T	p.T298I	Substitution - Missense	Large_intestine
COSM301033	c.463G>A	p.G155S	Substitution - Missense	Large_intestine
COSM5822589	c.125C>A	p.A42D	Substitution - Missense	Liver
COSM724366	c.228G>A	p.A76A	Substitution - coding silent	Pancreas
COSM3423697	c.277G>T	p.A93S	Substitution - Missense	Large_intestine
COSM1713599	c.941A>G	p.N314S	Substitution - Missense	Skin
COSM3731965	c.805C>T	p.R269C	Substitution - Missense	Stomach
COSM5718116	c.491C>T	p.P164L	Substitution - Missense	Skin
COSM3547345	c.1436G>A	p.G479E	Substitution - Missense	Skin
COSM1713593	c.289C>T	p.P97S	Substitution - Missense	Skin
COSM3547326	c.145C>T	p.L49F	Substitution - Missense	Skin
COSM5718116	c.491C>T	p.P164L	Substitution - Missense	Skin
COSM3389805	c.298+1G>C	p.?	Unknown	Pancreas
COSM3294758	c.153C>T	p.S51S	Substitution - coding silent	Skin
COSM5548739	c.457G>A	p.A153T	Substitution - Missense	Prostate
COSM1495071	c.60G>C	p.L20L	Substitution - coding silent	Kidney
COSM4134606	c.1160T>G	p.V387G	Substitution - Missense	Upper_aerodigestive_tract
COSM1412226	c.1113C>T	p.H371H	Substitution - coding silent	Stomach
COSM1205878	c.728G>T	p.R243L	Substitution - Missense	Large_intestine
COSM1205879	c.749G>A	p.R250Q	Substitution - Missense	Prostate
COSM3547344	c.1402C>T	p.P468S	Substitution - Missense	Skin
COSM5974080	c.705G>A	p.E235E	Substitution - coding silent	Upper_aerodigestive_tract
COSM3294781	c.829G>A	p.E277K	Substitution - Missense	Skin
COSM5804225	c.1493T>A	p.V498E	Substitution - Missense	Liver
COSM3547338	c.902C>T	p.S301F	Substitution - Missense	Skin
COSM4134606	c.1160T>G	p.V387G	Substitution - Missense	Thyroid
COSM1190277	c.372C>A	p.S124R	Substitution - Missense	Lung
COSM3547329	c.330C>T	p.S110S	Substitution - coding silent	Skin
COSM382228	c.215C>T	p.T72M	Substitution - Missense	Lung
COSM3294794	c.1073C>T	p.S358L	Substitution - Missense	Large_intestine
COSM127915	c.1053C>T	p.S351S	Substitution - coding silent	Upper_aerodigestive_tract
COSM4502288	c.609C>T	p.V203V	Substitution - coding silent	Skin
COSM4508580	c.780C>T	p.S260S	Substitution - coding silent	Skin
COSM1027510	c.1147C>T	p.R383C	Substitution - Missense	Endometrium
COSM3911510	c.664G>A	p.E222K	Substitution - Missense	Skin
COSM3547335	c.687T>G	p.P229P	Substitution - coding silent	Skin
COSM1632327	c.1199G>A	p.G400E	Substitution - Missense	Liver
COSM3841205	c.190A>C	p.T64P	Substitution - Missense	Breast
COSM226845	c.878G>A	p.R293K	Substitution - Missense	Skin
COSM4134607	c.1593C>T	p.H531H	Substitution - coding silent	Breast
COSM5707466	c.546C>A	p.Y182*	Substitution - Nonsense	Haematopoietic_and_lymphoid_tissue
COSM3720079	c.1054G>T	p.A352S	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3758609	c.738C>T	p.D246D	Substitution - coding silent	Large_intestine
COSM4878684	c.166C>T	p.R56C	Substitution - Missense	Thyroid
COSM4682130	c.1184A>G	p.K395R	Substitution - Missense	Large_intestine
COSM3963628	c.356A>G	p.Y119C	Substitution - Missense	Lung
COSM5468033	c.748C>T	p.R250*	Substitution - Nonsense	Large_intestine
COSM1412222	c.358G>T	p.G120C	Substitution - Missense	Large_intestine
COSM3547325	c.126C>T	p.A42A	Substitution - coding silent	Skin
COSM1713595	c.683G>A	p.G228E	Substitution - Missense	Skin
COSM1027503	c.529_530delTA	p.Y177fs*45	Deletion - Frameshift	Endometrium
COSM5784785	c.1569C>G	p.H523Q	Substitution - Missense	Breast
COSM5392254	c.490C>T	p.P164S	Substitution - Missense	Skin
COSM5392256	c.790G>A	p.D264N	Substitution - Missense	Skin
COSM1412225	c.1108G>A	p.V370M	Substitution - Missense	Liver
COSM3731965	c.805C>T	p.R269C	Substitution - Missense	Stomach
COSM5392254	c.490C>T	p.P164S	Substitution - Missense	Skin
COSM3294761	c.236A>T	p.Q79L	Substitution - Missense	Large_intestine
COSM5552303	c.1574A>G	p.D525G	Substitution - Missense	Prostate
COSM4099055	c.1461A>G	p.I487M	Substitution - Missense	Stomach
COSM4682131	c.1365G>A	p.L455L	Substitution - coding silent	Large_intestine
COSM5392257	c.1227C>A	p.T409T	Substitution - coding silent	Skin
COSM3841206	c.267T>C	p.P89P	Substitution - coding silent	Breast
COSM4451715	c.1369A>T	p.K457*	Substitution - Nonsense	Skin
COSM3294775	c.755G>A	p.R252Q	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5730162	c.396_397insTACACC	p.Y135_Q136insTY	Insertion - In frame	Skin
COSM4134606	c.1160T>G	p.V387G	Substitution - Missense	Upper_aerodigestive_tract
COSM3547327	c.193G>A	p.A65T	Substitution - Missense	Skin
COSM1641363	c.1436-6G>A	p.?	Unknown	Stomach
COSM1251617	c.1537C>T	p.H513Y	Substitution - Missense	Oesophagus
COSM1205877	c.502G>A	p.G168S	Substitution - Missense	Large_intestine
COSM4496122	c.468C>T	p.F156F	Substitution - coding silent	Skin
COSM4618036	c.698C>T	p.A233V	Substitution - Missense	Large_intestine
COSM724366	c.228G>A	p.A76A	Substitution - coding silent	Lung
COSM3547334	c.653C>T	p.S218L	Substitution - Missense	Skin
COSM3547336	c.699G>A	p.A233A	Substitution - coding silent	Skin
COSM4560971	c.864G>A	p.G288G	Substitution - coding silent	Skin
COSM301033	c.463G>A	p.G155S	Substitution - Missense	Small_intestine
COSM1713595	c.683G>A	p.G228E	Substitution - Missense	Skin
COSM1251616	c.719G>A	p.R240K	Substitution - Missense	Stomach
COSM5732946	c.702_703delAG	p.E235fs*19	Deletion - Frameshift	Pancreas

> Text Mining based Variations [ TOP ]
There is no record for EYA2.

Summary
Symbol	EYA2
Name	EYA transcriptional coactivator and phosphatase 2
Aliases	EAB1; eyes absent (Drosophila) homolog 2; eyes absent homolog 2 (Drosophila); Eyes absent homolog 2
Location	20q13.12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM) [ TOP ]
There is no PTM data

Summary
Symbol	EYA2
Name	EYA transcriptional coactivator and phosphatase 2
Aliases	EAB1; eyes absent (Drosophila) homolog 2; eyes absent homolog 2 (Drosophila); Eyes absent homolog 2
Location	20q13.12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	2.648	3.867	-0.107	0.898	NS
BRCA	Breast invasive carcinoma	112	1100	4.831	3.504	-1.293	2.48e-14	Under
CESC	Cervical and endocervical cancers	3	306	3.878	6.45	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	4.54	0.154	-4.038	1.05e-29	Under
ESCA	Esophageal carcinoma	11	185	3.688	3.553	-0.99	0.394	NS
GBM	Glioblastoma multiforme	5	166	3.292	4.532	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	5.734	2.36	-3.159	1.45e-14	Under
KIRC	Kidney renal clear cell carcinoma	72	534	3.247	0.949	-1.796	1.66e-18	Under
KIRP	Kidney renal papillary cell carcinoma	32	291	3.55	2.136	-1.5	0.000591	Under
LGG	Brain Lower Grade Glioma	0	530	NA	2.969	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	0.129	-2.035	-2.24	1.54e-10	Under
LUAD	Lung adenocarcinoma	59	517	1.452	1.955	0.6	0.069	NS
LUSC	Lung squamous cell carcinoma	51	501	1.948	4.993	2.598	7.38e-17	Over
OV	Ovarian serous cystadenocarcinoma	0	307	NA	6.752	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	3.048	2.941	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	-0.467	-1.285	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	5.664	5.706	-0.093	0.406	NS
READ	Rectum adenocarcinoma	10	167	2.915	0.323	-2.755	3.71e-05	Under
SARC	Sarcoma	2	263	2.791	4.262	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	-1.408	-0.307	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	4.181	1.261	-1.819	0.000662	Under
TGCT	Testicular Germ Cell Tumors	0	156	NA	0.78	NA	NA	NA
THCA	Thyroid carcinoma	59	509	5.249	3.944	-1.364	2.79e-14	Under
THYM	Thymoma	2	120	5.431	6.111	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	6.193	7.803	1.696	0.000207	Over

> Cancer Cell Line Encyclopedia (CCLE)

[ TOP ]

Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	3.9
Autonomic ganglia	CHP212	3.7
Autonomic ganglia	IMR32	10.4
Autonomic ganglia	KELLY	4
Autonomic ganglia	KPNRTBM1	4.1
Autonomic ganglia	KPNSI9S	3.9
Autonomic ganglia	KPNYN	3.9
Autonomic ganglia	MHHNB11	3.9
Autonomic ganglia	NB1	4.1
Autonomic ganglia	NH6	3.9
Autonomic ganglia	SHSY5Y	4
Autonomic ganglia	SIMA	3.7
Autonomic ganglia	SKNAS	4.3
Autonomic ganglia	SKNBE2	4.1
Autonomic ganglia	SKNDZ	4
Autonomic ganglia	SKNFI	4.5
Autonomic ganglia	SKNSH	4.5
Biliary tract	HUCCT1	3.5
Biliary tract	HUH28	8.5
Biliary tract	SNU1079	5.5
Biliary tract	SNU1196	3.8
Biliary tract	SNU245	3.8
Biliary tract	SNU308	4.6
Biliary tract	SNU478	5.3
Bone	143B	7.2
Bone	A673	4
Bone	CADOES1	5.6
Bone	CAL78	9.9
Bone	G292CLONEA141B1	7.3
Bone	HOS	4.7
Bone	HS706T	5.4
Bone	HS737T	6.7
Bone	HS819T	7.3
Bone	HS821T	4.3
Bone	HS822T	5.1
Bone	HS863T	4.1
Bone	HS870T	7.8
Bone	HS888T	4.9
Bone	MG63	8.3
Bone	MHHES1	3.8
Bone	OUMS27	4
Bone	RDES	4.1
Bone	SJSA1	3.9
Bone	SKES1	4
Bone	SKNMC	4.3
Bone	SW1353	4.2
Bone	T173	7.2
Bone	TC71	3.9
Bone	U2OS	5.8
Breast	AU565	8
Breast	BT20	5.6
Breast	BT474	3.9
Breast	BT483	5.5
Breast	BT549	4.4
Breast	CAL120	4.5
Breast	CAL148	6.4
Breast	CAL51	3.8
Breast	CAL851	4
Breast	CAMA1	4.1
Breast	DU4475	4.4
Breast	EFM192A	8.9
Breast	EFM19	7.2
Breast	EVSAT	3.9
Breast	HCC1143	4.2
Breast	HCC1187	4.6
Breast	HCC1395	3.6
Breast	HCC1419	3.9
Breast	HCC1428	4.7
Breast	HCC1500	3.7
Breast	HCC1569	10
Breast	HCC1599	7
Breast	HCC1806	4.4
Breast	HCC1937	4.6
Breast	HCC1954	8.6
Breast	HCC202	3.8
Breast	HCC2157	7.4
Breast	HCC2218	4.8
Breast	HCC38	4.3
Breast	HCC70	6.3
Breast	HDQP1	3.8
Breast	HMC18	4.6
Breast	HS274T	3.9
Breast	HS281T	3.9
Breast	HS343T	6.8
Breast	HS578T	4.1
Breast	HS606T	6.2
Breast	HS739T	4.6
Breast	HS742T	4.4
Breast	JIMT1	5
Breast	KPL1	5.2
Breast	MCF7	4.1
Breast	MDAMB134VI	4.3
Breast	MDAMB157	4.3
Breast	MDAMB175VII	4.2
Breast	MDAMB231	3.8
Breast	MDAMB361	4.6
Breast	MDAMB415	4.2
Breast	MDAMB436	4.5
Breast	MDAMB453	4
Breast	MDAMB468	7.8
Breast	SKBR3	8.3
Breast	T47D	4.9
Breast	UACC812	4.8
Breast	UACC893	4.3
Breast	YMB1	3.8
Breast	ZR751	4.4
Breast	ZR7530	5.7
Central nervous system	1321N1	4.5
Central nervous system	42MGBA	4.1
Central nervous system	8MGBA	3.8
Central nervous system	A172	3.8
Central nervous system	AM38	4
Central nervous system	BECKER	4.2
Central nervous system	CAS1	4.2
Central nervous system	CCFSTTG1	4.3
Central nervous system	D283MED	8.8
Central nervous system	D341MED	6.8
Central nervous system	DAOY	5.2
Central nervous system	DBTRG05MG	4
Central nervous system	DKMG	3.9
Central nervous system	GAMG	4.1
Central nervous system	GB1	5.1
Central nervous system	GI1	5.8
Central nervous system	GMS10	4
Central nervous system	GOS3	4.2
Central nervous system	H4	4.6
Central nervous system	HS683	3.9
Central nervous system	KALS1	4.5
Central nervous system	KG1C	6.2
Central nervous system	KNS42	4.1
Central nervous system	KNS60	4
Central nervous system	KNS81	4.4
Central nervous system	KS1	4.3
Central nervous system	LN18	4.5
Central nervous system	LN229	4.2
Central nervous system	M059K	4.3
Central nervous system	MOGGCCM	3.7
Central nervous system	MOGGUVW	4.1
Central nervous system	NMCG1	3.8
Central nervous system	ONS76	4.1
Central nervous system	SF126	4.2
Central nervous system	SF295	3.8
Central nervous system	SNB19	5.7
Central nervous system	SNU1105	4
Central nervous system	SNU201	3.9
Central nervous system	SNU466	6.5
Central nervous system	SNU489	4.1
Central nervous system	SNU626	3.9
Central nervous system	SNU738	9.2
Central nervous system	SW1088	4.2
Central nervous system	SW1783	4.1
Central nervous system	T98G	5.1
Central nervous system	TM31	7.8
Central nervous system	U118MG	4.1
Central nervous system	U138MG	3.7
Central nervous system	U251MG	4
Central nervous system	U87MG	4
Central nervous system	YH13	4.2
Central nervous system	YKG1	3.9
Endometrium	AN3CA	4.1
Endometrium	COLO684	9.3
Endometrium	EFE184	3.9
Endometrium	EN	4.5
Endometrium	ESS1	4.1
Endometrium	HEC108	4.1
Endometrium	HEC151	4.2
Endometrium	HEC1A	4.1
Endometrium	HEC1B	4
Endometrium	HEC251	4
Endometrium	HEC265	4.2
Endometrium	HEC50B	3.9
Endometrium	HEC59	3.8
Endometrium	HEC6	4
Endometrium	ISHIKAWAHERAKLIO02ER	4.2
Endometrium	JHUEM1	5.7
Endometrium	JHUEM2	4.4
Endometrium	JHUEM3	3.9
Endometrium	KLE	4.2
Endometrium	MFE280	4.4
Endometrium	MFE296	4.3
Endometrium	MFE319	4.4
Endometrium	RL952	8.8
Endometrium	SNGM	3.9
Endometrium	SNU1077	4.1
Endometrium	SNU685	4
Endometrium	TEN	4.2
Haematopoietic and lymphoid	697	4.2
Haematopoietic and lymphoid	A3KAW	5.2
Haematopoietic and lymphoid	A4FUK	4.6
Haematopoietic and lymphoid	ALLSIL	3.9
Haematopoietic and lymphoid	AML193	4.3
Haematopoietic and lymphoid	AMO1	4.6
Haematopoietic and lymphoid	BCP1	6.5
Haematopoietic and lymphoid	BDCM	4.1
Haematopoietic and lymphoid	BL41	4.2
Haematopoietic and lymphoid	BL70	4.7
Haematopoietic and lymphoid	BV173	4
Haematopoietic and lymphoid	CA46	3.9
Haematopoietic and lymphoid	CI1	4.1
Haematopoietic and lymphoid	CMK115	4.1
Haematopoietic and lymphoid	CMK86	3.8
Haematopoietic and lymphoid	CMK	4.1
Haematopoietic and lymphoid	CMLT1	5.3
Haematopoietic and lymphoid	COLO775	3.7
Haematopoietic and lymphoid	DAUDI	4.6
Haematopoietic and lymphoid	DB	4.1
Haematopoietic and lymphoid	DEL	4
Haematopoietic and lymphoid	DND41	4.3
Haematopoietic and lymphoid	DOHH2	4
Haematopoietic and lymphoid	EB1	4.5
Haematopoietic and lymphoid	EB2	4.2
Haematopoietic and lymphoid	EHEB	4.2
Haematopoietic and lymphoid	EJM	3.9
Haematopoietic and lymphoid	EM2	3.9
Haematopoietic and lymphoid	EOL1	4.4
Haematopoietic and lymphoid	F36P	4.3
Haematopoietic and lymphoid	GA10	4.7
Haematopoietic and lymphoid	GDM1	4.2
Haematopoietic and lymphoid	GRANTA519	4.6
Haematopoietic and lymphoid	HDLM2	4
Haematopoietic and lymphoid	HDMYZ	4.2
Haematopoietic and lymphoid	HEL9217	4.1
Haematopoietic and lymphoid	HEL	3.9
Haematopoietic and lymphoid	HH	4.2
Haematopoietic and lymphoid	HL60	4.7
Haematopoietic and lymphoid	HPBALL	4.2
Haematopoietic and lymphoid	HS604T	4.1
Haematopoietic and lymphoid	HS611T	4
Haematopoietic and lymphoid	HS616T	4.3
Haematopoietic and lymphoid	HS751T	3.9
Haematopoietic and lymphoid	HT	4.4
Haematopoietic and lymphoid	HTK	8.3
Haematopoietic and lymphoid	HUNS1	8.5
Haematopoietic and lymphoid	HUT102	4.1
Haematopoietic and lymphoid	HUT78	4
Haematopoietic and lymphoid	JEKO1	4.1
Haematopoietic and lymphoid	JK1	4.3
Haematopoietic and lymphoid	JM1	4.3
Haematopoietic and lymphoid	JURKAT	4
Haematopoietic and lymphoid	JURLMK1	4.2
Haematopoietic and lymphoid	JVM2	4.1
Haematopoietic and lymphoid	JVM3	4.4
Haematopoietic and lymphoid	K562	4.3
Haematopoietic and lymphoid	KARPAS299	4.1
Haematopoietic and lymphoid	KARPAS422	3.8
Haematopoietic and lymphoid	KARPAS620	4.1
Haematopoietic and lymphoid	KASUMI1	3.9
Haematopoietic and lymphoid	KASUMI2	4
Haematopoietic and lymphoid	KASUMI6	4.2
Haematopoietic and lymphoid	KCL22	4
Haematopoietic and lymphoid	KE37	3.9
Haematopoietic and lymphoid	KE97	5.2
Haematopoietic and lymphoid	KG1	4
Haematopoietic and lymphoid	KHM1B	5
Haematopoietic and lymphoid	KIJK	4.2
Haematopoietic and lymphoid	KMH2	7.9
Haematopoietic and lymphoid	KMM1	4.2
Haematopoietic and lymphoid	KMS11	9.7
Haematopoietic and lymphoid	KMS12BM	4.3
Haematopoietic and lymphoid	KMS18	7.3
Haematopoietic and lymphoid	KMS20	9.3
Haematopoietic and lymphoid	KMS21BM	4.6
Haematopoietic and lymphoid	KMS26	8.1
Haematopoietic and lymphoid	KMS27	4.3
Haematopoietic and lymphoid	KMS28BM	9.1
Haematopoietic and lymphoid	KMS34	8.6
Haematopoietic and lymphoid	KO52	4.1
Haematopoietic and lymphoid	KOPN8	4.1
Haematopoietic and lymphoid	KU812	3.8
Haematopoietic and lymphoid	KYO1	4.8
Haematopoietic and lymphoid	L1236	4.1
Haematopoietic and lymphoid	L363	4.2
Haematopoietic and lymphoid	L428	4.2
Haematopoietic and lymphoid	L540	4.2
Haematopoietic and lymphoid	LAMA84	4.3
Haematopoietic and lymphoid	LOUCY	4
Haematopoietic and lymphoid	LP1	4.1
Haematopoietic and lymphoid	M07E	4
Haematopoietic and lymphoid	MC116	4.2
Haematopoietic and lymphoid	ME1	4.5
Haematopoietic and lymphoid	MEC1	4.2
Haematopoietic and lymphoid	MEC2	3.7
Haematopoietic and lymphoid	MEG01	4.3
Haematopoietic and lymphoid	MHHCALL2	4.1
Haematopoietic and lymphoid	MHHCALL3	4.1
Haematopoietic and lymphoid	MHHCALL4	4.2
Haematopoietic and lymphoid	MINO	4
Haematopoietic and lymphoid	MJ	5.2
Haematopoietic and lymphoid	MM1S	4
Haematopoietic and lymphoid	MOLM13	3.9
Haematopoietic and lymphoid	MOLM16	4.4
Haematopoietic and lymphoid	MOLM6	4.1
Haematopoietic and lymphoid	MOLP2	4.1
Haematopoietic and lymphoid	MOLP8	3.9
Haematopoietic and lymphoid	MOLT13	3.9
Haematopoietic and lymphoid	MOLT16	4.2
Haematopoietic and lymphoid	MOLT4	4.3
Haematopoietic and lymphoid	MONOMAC1	3.9
Haematopoietic and lymphoid	MONOMAC6	3.9
Haematopoietic and lymphoid	MOTN1	4
Haematopoietic and lymphoid	MUTZ5	4.2
Haematopoietic and lymphoid	MV411	4
Haematopoietic and lymphoid	NALM19	4.3
Haematopoietic and lymphoid	NALM1	4.2
Haematopoietic and lymphoid	NALM6	4.1
Haematopoietic and lymphoid	NAMALWA	4
Haematopoietic and lymphoid	NB4	4
Haematopoietic and lymphoid	NCIH929	4.4
Haematopoietic and lymphoid	NCO2	4.3
Haematopoietic and lymphoid	NOMO1	4
Haematopoietic and lymphoid	NUDHL1	4.3
Haematopoietic and lymphoid	NUDUL1	4.5
Haematopoietic and lymphoid	OCIAML2	3.8
Haematopoietic and lymphoid	OCIAML3	3.7
Haematopoietic and lymphoid	OCIAML5	4.2
Haematopoietic and lymphoid	OCILY10	4
Haematopoietic and lymphoid	OCILY19	4.4
Haematopoietic and lymphoid	OCILY3	4.2
Haematopoietic and lymphoid	OCIM1	4.3
Haematopoietic and lymphoid	OPM2	4.4
Haematopoietic and lymphoid	P12ICHIKAWA	4.5
Haematopoietic and lymphoid	P31FUJ	4.1
Haematopoietic and lymphoid	P3HR1	4.3
Haematopoietic and lymphoid	PCM6	4.2
Haematopoietic and lymphoid	PEER	4.5
Haematopoietic and lymphoid	PF382	4.2
Haematopoietic and lymphoid	PFEIFFER	4.5
Haematopoietic and lymphoid	PL21	3.8
Haematopoietic and lymphoid	RAJI	4.6
Haematopoietic and lymphoid	RCHACV	4.3
Haematopoietic and lymphoid	REC1	4.6
Haematopoietic and lymphoid	REH	4.3
Haematopoietic and lymphoid	RI1	3.9
Haematopoietic and lymphoid	RL	4.3
Haematopoietic and lymphoid	RPMI8226	5.5
Haematopoietic and lymphoid	RPMI8402	4.4
Haematopoietic and lymphoid	RS411	4.2
Haematopoietic and lymphoid	SEM	4.1
Haematopoietic and lymphoid	SET2	4.3
Haematopoietic and lymphoid	SIGM5	4.1
Haematopoietic and lymphoid	SKM1	4.2
Haematopoietic and lymphoid	SKMM2	6.4
Haematopoietic and lymphoid	SR786	4.1
Haematopoietic and lymphoid	ST486	4.2
Haematopoietic and lymphoid	SUDHL10	7.9
Haematopoietic and lymphoid	SUDHL1	4.5
Haematopoietic and lymphoid	SUDHL4	9.6
Haematopoietic and lymphoid	SUDHL5	4.3
Haematopoietic and lymphoid	SUDHL6	4.1
Haematopoietic and lymphoid	SUDHL8	4.2
Haematopoietic and lymphoid	SUPB15	4.1
Haematopoietic and lymphoid	SUPHD1	4
Haematopoietic and lymphoid	SUPM2	4.3
Haematopoietic and lymphoid	SUPT11	4.2
Haematopoietic and lymphoid	SUPT1	3.9
Haematopoietic and lymphoid	TALL1	4.3
Haematopoietic and lymphoid	TF1	4
Haematopoietic and lymphoid	THP1	4.2
Haematopoietic and lymphoid	TO175T	4
Haematopoietic and lymphoid	TOLEDO	4
Haematopoietic and lymphoid	U266B1	9.6
Haematopoietic and lymphoid	U937	4.4
Haematopoietic and lymphoid	UT7	4.1
Haematopoietic and lymphoid	WSUDLCL2	8.8
Kidney	769P	4
Kidney	786O	3.8
Kidney	A498	6.6
Kidney	A704	4.1
Kidney	ACHN	3.9
Kidney	BFTC909	4
Kidney	CAKI1	4.3
Kidney	CAKI2	3.9
Kidney	CAL54	3.6
Kidney	KMRC1	4.1
Kidney	KMRC20	4
Kidney	KMRC2	4.1
Kidney	KMRC3	4.1
Kidney	OSRC2	4.4
Kidney	RCC10RGB	4.9
Kidney	SNU1272	3.9
Kidney	SNU349	4.1
Kidney	TUHR10TKB	6.8
Kidney	TUHR14TKB	4.5
Kidney	TUHR4TKB	4.2
Kidney	VMRCRCW	4
Kidney	VMRCRCZ	3.7
Large intestine	C2BBE1	4.1
Large intestine	CCK81	4.3
Large intestine	CL11	3.8
Large intestine	CL14	4
Large intestine	CL34	4
Large intestine	CL40	4.1
Large intestine	COLO205	4.1
Large intestine	COLO320	4.2
Large intestine	COLO678	3.9
Large intestine	CW2	4.2
Large intestine	DLD1	4
Large intestine	GP2D	4.4
Large intestine	HCC56	3.9
Large intestine	HCT116	3.9
Large intestine	HCT15	4
Large intestine	HS675T	4.2
Large intestine	HS698T	3.9
Large intestine	HT115	4
Large intestine	HT29	4
Large intestine	HT55	4.2
Large intestine	KM12	4
Large intestine	LOVO	4.2
Large intestine	LS1034	4
Large intestine	LS123	4.3
Large intestine	LS180	4.3
Large intestine	LS411N	4.1
Large intestine	LS513	3.8
Large intestine	MDST8	6.1
Large intestine	NCIH508	4
Large intestine	NCIH716	4
Large intestine	NCIH747	3.7
Large intestine	OUMS23	9.6
Large intestine	RCM1	4
Large intestine	RKO	4.1
Large intestine	SKCO1	4.3
Large intestine	SNU1040	4.4
Large intestine	SNU1197	3.9
Large intestine	SNU175	4.2
Large intestine	SNU283	4.4
Large intestine	SNU407	4
Large intestine	SNU503	7.8
Large intestine	SNU61	4.6
Large intestine	SNU81	3.9
Large intestine	SNUC1	4.5
Large intestine	SNUC2A	4.2
Large intestine	SNUC4	4
Large intestine	SNUC5	3.7
Large intestine	SW1116	4.2
Large intestine	SW1417	4.2
Large intestine	SW1463	4.2
Large intestine	SW403	4
Large intestine	SW480	4.3
Large intestine	SW48	4
Large intestine	SW620	3.9
Large intestine	SW837	3.8
Large intestine	SW948	3.9
Large intestine	T84	4.1
Liver	ALEXANDERCELLS	4
Liver	C3A	4.4
Liver	HEP3B217	3.9
Liver	HEPG2	3.9
Liver	HLE	4.1
Liver	HLF	4.1
Liver	HUH1	4.3
Liver	HUH6	4.1
Liver	HUH7	3.9
Liver	JHH1	4.4
Liver	JHH2	3.9
Liver	JHH4	4
Liver	JHH5	3.9
Liver	JHH6	3.9
Liver	JHH7	4
Liver	LI7	4.1
Liver	PLCPRF5	3.7
Liver	SKHEP1	3.8
Liver	SNU182	5.2
Liver	SNU387	4.3
Liver	SNU398	7.7
Liver	SNU423	4.8
Liver	SNU449	4.3
Liver	SNU475	4.6
Liver	SNU761	3.9
Liver	SNU878	5.3
Liver	SNU886	3.9
Lung	A549	5.8
Lung	ABC1	8.4
Lung	BEN	4.3
Lung	CAL12T	4
Lung	CALU1	4.1
Lung	CALU3	4.1
Lung	CALU6	4
Lung	CHAGOK1	4.2
Lung	COLO668	7.8
Lung	COLO699	4
Lung	CORL105	3.8
Lung	CORL23	3.8
Lung	CORL24	9.4
Lung	CORL279	6.7
Lung	CORL311	4.3
Lung	CORL47	8.6
Lung	CORL51	6
Lung	CORL88	4.6
Lung	CORL95	9.2
Lung	CPCN	8.4
Lung	DMS114	4.4
Lung	DMS153	5.3
Lung	DMS273	8.1
Lung	DMS454	4.1
Lung	DMS53	5.6
Lung	DMS79	4.7
Lung	DV90	4.5
Lung	EBC1	3.9
Lung	EPLC272H	6.8
Lung	HARA	7.6
Lung	HCC1171	6.7
Lung	HCC1195	7.1
Lung	HCC15	3.9
Lung	HCC2279	7.1
Lung	HCC2935	4.4
Lung	HCC33	8.1
Lung	HCC366	3.9
Lung	HCC4006	7.9
Lung	HCC44	4.4
Lung	HCC78	4.3
Lung	HCC827	4
Lung	HCC95	5.4
Lung	HLC1	4.2
Lung	HLFA	4.1
Lung	HS229T	4.4
Lung	HS618T	4.2
Lung	IALM	4.2
Lung	KNS62	8.7
Lung	LC1F	5.8
Lung	LC1SQSF	5
Lung	LCLC103H	4
Lung	LCLC97TM1	3.9
Lung	LK2	3.9
Lung	LOUNH91	3.9
Lung	LU65	4.2
Lung	LU99	4.2
Lung	LUDLU1	5.4
Lung	LXF289	3.8
Lung	MORCPR	4.4
Lung	NCIH1048	6.1
Lung	NCIH1092	5
Lung	NCIH1105	7.5
Lung	NCIH1155	5.1
Lung	NCIH1184	6.1
Lung	NCIH1299	4.3
Lung	NCIH1339	4.1
Lung	NCIH1341	5.6
Lung	NCIH1355	4.3
Lung	NCIH1373	4
Lung	NCIH1385	3.5
Lung	NCIH1395	4.4
Lung	NCIH1435	3.9
Lung	NCIH1436	8.1
Lung	NCIH1437	4.1
Lung	NCIH146	9.3
Lung	NCIH1563	5.3
Lung	NCIH1568	5
Lung	NCIH1573	7.1
Lung	NCIH1581	3.9
Lung	NCIH1618	8.4
Lung	NCIH1623	4.3
Lung	NCIH1648	6
Lung	NCIH1650	5.2
Lung	NCIH1651	4.1
Lung	NCIH1666	8.8
Lung	NCIH1693	4.3
Lung	NCIH1694	7.5
Lung	NCIH1703	4.7
Lung	NCIH1734	5.7
Lung	NCIH1755	4.2
Lung	NCIH1781	8.7
Lung	NCIH1792	3.9
Lung	NCIH1793	7.7
Lung	NCIH1836	7.6
Lung	NCIH1838	4.3
Lung	NCIH1869	4.2
Lung	NCIH1876	8.5
Lung	NCIH1915	4
Lung	NCIH1930	7.5
Lung	NCIH1944	3.7
Lung	NCIH1963	5.8
Lung	NCIH196	4.3
Lung	NCIH1975	3.9
Lung	NCIH2009	4.1
Lung	NCIH2023	4.6
Lung	NCIH2029	7.3
Lung	NCIH2030	7.9
Lung	NCIH2066	5
Lung	NCIH2081	6.5
Lung	NCIH2085	4
Lung	NCIH2087	4.3
Lung	NCIH209	9.9
Lung	NCIH2106	3.7
Lung	NCIH2110	4
Lung	NCIH211	6.7
Lung	NCIH2122	4
Lung	NCIH2126	7.6
Lung	NCIH2141	8.7
Lung	NCIH2170	8
Lung	NCIH2171	10
Lung	NCIH2172	4.3
Lung	NCIH2196	6.1
Lung	NCIH2227	8.4
Lung	NCIH2228	3.8
Lung	NCIH226	4
Lung	NCIH2286	3.9
Lung	NCIH2291	4.5
Lung	NCIH2342	5
Lung	NCIH2347	4.2
Lung	NCIH23	4.1
Lung	NCIH2405	4
Lung	NCIH2444	7.4
Lung	NCIH292	8
Lung	NCIH322	8.2
Lung	NCIH3255	3.9
Lung	NCIH358	3.7
Lung	NCIH441	4.2
Lung	NCIH446	6
Lung	NCIH460	4.1
Lung	NCIH510	5.5
Lung	NCIH520	4.2
Lung	NCIH522	4.2
Lung	NCIH524	11.4
Lung	NCIH526	9.3
Lung	NCIH596	7
Lung	NCIH647	4
Lung	NCIH650	4
Lung	NCIH661	4.2
Lung	NCIH69	9.4
Lung	NCIH727	9.1
Lung	NCIH810	6
Lung	NCIH82	10.6
Lung	NCIH838	3.9
Lung	NCIH841	4.1
Lung	NCIH854	4
Lung	NCIH889	8.4
Lung	PC14	3.9
Lung	RERFLCAD1	4.1
Lung	RERFLCAD2	4.4
Lung	RERFLCAI	4
Lung	RERFLCKJ	7.5
Lung	RERFLCMS	4.4
Lung	RERFLCSQ1	9.2
Lung	SBC5	5.8
Lung	SCLC21H	8.3
Lung	SHP77	8.3
Lung	SKLU1	3.9
Lung	SKMES1	4.2
Lung	SQ1	4.5
Lung	SW1271	4.1
Lung	SW1573	4.2
Lung	SW900	4.2
Lung	VMRCLCD	3.7
Lung	VMRCLCP	9.2
Oesophagus	COLO680N	4.2
Oesophagus	ECGI10	7.3
Oesophagus	KYSE140	6.4
Oesophagus	KYSE150	4.2
Oesophagus	KYSE180	5.1
Oesophagus	KYSE270	5.5
Oesophagus	KYSE30	8.1
Oesophagus	KYSE410	6.3
Oesophagus	KYSE450	8.6
Oesophagus	KYSE510	7.2
Oesophagus	KYSE520	4.2
Oesophagus	KYSE70	4.4
Oesophagus	OE19	4.3
Oesophagus	OE33	4.4
Oesophagus	TE10	9
Oesophagus	TE11	5.9
Oesophagus	TE14	5.7
Oesophagus	TE15	7.4
Oesophagus	TE1	6.5
Oesophagus	TE4	6.6
Oesophagus	TE5	10.8
Oesophagus	TE6	6.2
Oesophagus	TE8	8.2
Oesophagus	TE9	8.7
Oesophagus	TT	3.9
Ovary	59M	4
Ovary	A2780	4.1
Ovary	CAOV3	4.3
Ovary	CAOV4	5.5
Ovary	COLO704	8.3
Ovary	COV318	4.5
Ovary	COV362	5.6
Ovary	COV434	4.2
Ovary	COV504	10.3
Ovary	COV644	4.1
Ovary	EFO21	4
Ovary	EFO27	3.7
Ovary	ES2	4.1
Ovary	FUOV1	4.1
Ovary	HEYA8	4.3
Ovary	HS571T	4.2
Ovary	IGROV1	4
Ovary	JHOC5	4
Ovary	JHOM1	3.8
Ovary	JHOM2B	4.2
Ovary	JHOS2	4.7
Ovary	JHOS4	6.2
Ovary	KURAMOCHI	3.7
Ovary	MCAS	4.1
Ovary	NIHOVCAR3	5.1
Ovary	OAW28	5.6
Ovary	OAW42	4.2
Ovary	OC314	4
Ovary	OC316	4.1
Ovary	ONCODG1	6
Ovary	OV56	4.2
Ovary	OV7	5.3
Ovary	OV90	4.1
Ovary	OVCAR4	9.4
Ovary	OVCAR8	3.9
Ovary	OVISE	4.1
Ovary	OVK18	4
Ovary	OVKATE	8.7
Ovary	OVMANA	4
Ovary	OVSAHO	10.4
Ovary	OVTOKO	4.1
Ovary	RMGI	4.1
Ovary	RMUGS	4.5
Ovary	SKOV3	4.1
Ovary	SNU119	5.8
Ovary	SNU840	4
Ovary	SNU8	4.7
Ovary	TOV112D	4.1
Ovary	TOV21G	3.9
Ovary	TYKNU	4.2
Pancreas	ASPC1	3.9
Pancreas	BXPC3	7.5
Pancreas	CAPAN1	4.5
Pancreas	CAPAN2	3.8
Pancreas	CFPAC1	4
Pancreas	DANG	4
Pancreas	HPAC	6.2
Pancreas	HPAFII	4.1
Pancreas	HS766T	4.3
Pancreas	HUPT3	4.2
Pancreas	HUPT4	3.9
Pancreas	KCIMOH1	4.1
Pancreas	KLM1	8.5
Pancreas	KP2	6.9
Pancreas	KP3	4.2
Pancreas	KP4	4.6
Pancreas	L33	6.3
Pancreas	MIAPACA2	3.9
Pancreas	PANC0203	4.3
Pancreas	PANC0213	5.2
Pancreas	PANC0327	4
Pancreas	PANC0403	7.4
Pancreas	PANC0504	3.9
Pancreas	PANC0813	6.4
Pancreas	PANC1005	4.1
Pancreas	PANC1	4.6
Pancreas	PATU8902	4.1
Pancreas	PATU8988S	4.1
Pancreas	PATU8988T	4.5
Pancreas	PK1	8.1
Pancreas	PK45H	3.8
Pancreas	PK59	4
Pancreas	PL45	4
Pancreas	PSN1	3.9
Pancreas	QGP1	4
Pancreas	SNU213	5.8
Pancreas	SNU324	4.1
Pancreas	SNU410	4.2
Pancreas	SU8686	4.2
Pancreas	SUIT2	4.2
Pancreas	SW1990	4
Pancreas	T3M4	4.7
Pancreas	TCCPAN2	4
Pancreas	YAPC	6.3
Pleura	ACCMESO1	4.1
Pleura	DM3	5.4
Pleura	ISTMES1	4.1
Pleura	ISTMES2	4
Pleura	JL1	4.6
Pleura	MPP89	4.2
Pleura	MSTO211H	3.7
Pleura	NCIH2052	4.4
Pleura	NCIH2452	3.9
Pleura	NCIH28	4.2
Prostate	22RV1	4.1
Prostate	DU145	4.1
Prostate	LNCAPCLONEFGC	4.5
Prostate	MDAPCA2B	6.5
Prostate	NCIH660	3.9
Prostate	PC3	3.9
Prostate	VCAP	6.7
Salivary gland	A253	5.1
Salivary gland	YD15	4.1
Skin	A101D	4
Skin	A2058	3.7
Skin	A375	3.8
Skin	C32	4
Skin	CHL1	3.6
Skin	CJM	4
Skin	COLO679	4.2
Skin	COLO741	4.1
Skin	COLO783	7.6
Skin	COLO792	4
Skin	COLO800	3.7
Skin	COLO818	4.1
Skin	COLO829	4.1
Skin	COLO849	4
Skin	G361	4
Skin	GRM	3.9
Skin	HMCB	4.1
Skin	HS294T	5.3
Skin	HS600T	4.6
Skin	HS688AT	6.2
Skin	HS695T	4.4
Skin	HS839T	5.6
Skin	HS852T	4.6
Skin	HS895T	4.3
Skin	HS934T	9.2
Skin	HS936T	4.4
Skin	HS939T	4
Skin	HS940T	4.5
Skin	HS944T	3.9
Skin	HT144	4.1
Skin	IGR1	4.6
Skin	IGR37	4.2
Skin	IGR39	4
Skin	IPC298	4.2
Skin	K029AX	4.9
Skin	LOXIMVI	4.2
Skin	MALME3M	4.2
Skin	MDAMB435S	4
Skin	MELHO	4
Skin	MELJUSO	4.1
Skin	MEWO	4.1
Skin	RPMI7951	4.1
Skin	RVH421	4.1
Skin	SH4	4.2
Skin	SKMEL1	3.8
Skin	SKMEL24	6.1
Skin	SKMEL28	4.1
Skin	SKMEL2	4.4
Skin	SKMEL30	4.1
Skin	SKMEL31	4.9
Skin	SKMEL3	7.8
Skin	SKMEL5	4.3
Skin	UACC257	3.9
Skin	UACC62	5.8
Skin	WM115	4.1
Skin	WM1799	4
Skin	WM2664	3.8
Skin	WM793	3.9
Skin	WM88	4.1
Skin	WM983B	4
Small intestine	HUTU80	4.3
Soft tissue	A204	4.5
Soft tissue	G401	4
Soft tissue	G402	4.3
Soft tissue	GCT	4.2
Soft tissue	HS729	7.1
Soft tissue	HT1080	4.1
Soft tissue	KYM1	4.2
Soft tissue	MESSA	4.2
Soft tissue	RD	4.1
Soft tissue	RH30	4.1
Soft tissue	RH41	7
Soft tissue	RKN	4.2
Soft tissue	S117	3.8
Soft tissue	SJRH30	9.6
Soft tissue	SKLMS1	4
Soft tissue	SKUT1	4.2
Soft tissue	TE125T	4.6
Soft tissue	TE159T	9.1
Soft tissue	TE441T	5
Soft tissue	TE617T	4.7
Stomach	2313287	4
Stomach	AGS	4
Stomach	AZ521	5
Stomach	ECC10	4.1
Stomach	ECC12	4.1
Stomach	FU97	4.8
Stomach	GCIY	4
Stomach	GSS	4.7
Stomach	GSU	4
Stomach	HGC27	4.5
Stomach	HS746T	3.8
Stomach	HUG1N	5.7
Stomach	IM95	4
Stomach	KATOIII	6.7
Stomach	KE39	4
Stomach	LMSU	4
Stomach	MKN1	4.2
Stomach	MKN45	4.1
Stomach	MKN74	4.1
Stomach	MKN7	4.6
Stomach	NCCSTCK140	9.6
Stomach	NCIN87	8.3
Stomach	NUGC2	9.7
Stomach	NUGC3	6.4
Stomach	NUGC4	4.1
Stomach	OCUM1	4.3
Stomach	RERFGC1B	7
Stomach	SH10TC	5.7
Stomach	SNU16	4.1
Stomach	SNU1	4.2
Stomach	SNU216	4.4
Stomach	SNU520	4.1
Stomach	SNU5	4.3
Stomach	SNU601	3.9
Stomach	SNU620	8
Stomach	SNU668	4
Stomach	SNU719	3.9
Stomach	TGBC11TKB	3.7
Thyroid	8305C	4.1
Thyroid	8505C	4.1
Thyroid	BCPAP	3.8
Thyroid	BHT101	4.3
Thyroid	CAL62	3.9
Thyroid	CGTHW1	6.2
Thyroid	FTC133	3.9
Thyroid	FTC238	4
Thyroid	ML1	3.9
Thyroid	SW579	4.9
Thyroid	TT2609C02	3.8
Thyroid	TT	4
Upper aerodigestive tract	BHY	4.5
Upper aerodigestive tract	BICR16	5
Upper aerodigestive tract	BICR18	6.6
Upper aerodigestive tract	BICR22	4.2
Upper aerodigestive tract	BICR31	5.5
Upper aerodigestive tract	BICR56	4.6
Upper aerodigestive tract	BICR6	9.2
Upper aerodigestive tract	CAL27	4.9
Upper aerodigestive tract	CAL33	9.4
Upper aerodigestive tract	DETROIT562	8
Upper aerodigestive tract	FADU	6.7
Upper aerodigestive tract	HS840T	3.8
Upper aerodigestive tract	HSC2	7.9
Upper aerodigestive tract	HSC3	4.1
Upper aerodigestive tract	HSC4	5.2
Upper aerodigestive tract	PECAPJ15	6.1
Upper aerodigestive tract	PECAPJ34CLONEC12	4.2
Upper aerodigestive tract	PECAPJ41CLONED2	3.9
Upper aerodigestive tract	PECAPJ49	7.2
Upper aerodigestive tract	SCC15	6.9
Upper aerodigestive tract	SCC25	4
Upper aerodigestive tract	SCC4	4.4
Upper aerodigestive tract	SCC9	4.6
Upper aerodigestive tract	SNU1076	6.5
Upper aerodigestive tract	SNU1214	3.8
Upper aerodigestive tract	SNU46	5.5
Upper aerodigestive tract	SNU899	9.8
Upper aerodigestive tract	YD10B	4.4
Upper aerodigestive tract	YD38	4.3
Upper aerodigestive tract	YD8	5.8
Urinary tract	5637	4.7
Urinary tract	639V	3.9
Urinary tract	647V	4.2
Urinary tract	BC3C	6.1
Urinary tract	BFTC905	6.6
Urinary tract	CAL29	8.3
Urinary tract	HS172T	4
Urinary tract	HT1197	3.8
Urinary tract	HT1376	3.9
Urinary tract	J82	3.9
Urinary tract	JMSU1	4
Urinary tract	KMBC2	6.1
Urinary tract	KU1919	4
Urinary tract	RT11284	7.2
Urinary tract	RT112	9.1
Urinary tract	RT4	4.1
Urinary tract	SCABER	4.5
Urinary tract	SW1710	3.9
Urinary tract	SW780	4.7
Urinary tract	T24	7.1
Urinary tract	TCCSUP	3.7
Urinary tract	UMUC1	7.9
Urinary tract	UMUC3	4.1
Urinary tract	VMCUB1	4

> The Human Protein Atlas (HPA)

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Tissue	Expression Level (TPM)
Adipose tissue	13.2
Adrenal gland	1.9
Appendix	3.2
Bone marrow	0
Breast	10.2
Cerebral cortex	6.5
Cervix, uterine	75.8
Colon	6.7
Duodenum	0.3
Endometrium	28.1
Epididymis	4.3
Esophagus	21.2
Fallopian tube	49.5
Gallbladder	2.7
Heart muscle	1.4
Kidney	5
Liver	0.5
Lung	2.3
Lymph node	0.9
Ovary	0.4
Pancreas	0.4
Parathyroid gland	18.8
Placenta	8.7
Prostate	26.1
Rectum	3.1
Salivary gland	13.5
Seminal vesicle	12.5
Skeletal muscle	0.3
Skin	2
Small intestine	0.4
Smooth muscle	2.6
Spleen	0.7
Stomach	8.4
Testis	9.3
Thyroid gland	18.1
Tonsil	5.9
Urinary bladder	6.8

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
19901965	overexpression	Malignant Peripheral Nerve Sheath Tumor	We identified a decrease in DACH1 expression, and increases in the expressions of PAX6, EYA1, EYA2, EYA4, and SIX1-4 genes.
26837415	overexpression	Lung Adenocarcinoma	Here we found that miR-30a was decreased in lung adenocarcinoma A549 cells and in tissue samples from 14 patients by qRT-PCR, and also found that overexpression of miR-30a in A549 cells inhibited migration and invasion but not cell proliferation and cell cycle progression by wound-healing assay, matrigel invasion assay, MTS-based cell proliferation assay, and flow cytometry-based cell cycle analysis, respectively. Taken together, our results demonstrate that overexpression of miR-30a in lung adenocarcinoma A549 cells can inhibit cell migration and invasion, which is partially attributed to the decrease of EYA2 expression.
26329363	overexpression (hypomethylation)	Lung Adenocarcinoma	We found that EYA2 was aberrantly upregulated in the lung adenocarcinoma cells. The results showed that the aberrant hypomethylation and overexpression of the eya2 gene were associated with lung adenocarcinoma oncogenesis.
24810906	loss of expression	Pancreatic Carcinoma	We found loss of tumoral Eya2 expression in 63% of pancreatic cancers (120/189 cases).
24508260	overexpression	Breast Carcinoma	Moreover, miR-30a expression was downregulated in breast cancer patients, and negatively correlated with Eya2, which was upregulated in breast cancer patients.
22987659	overexpression	Cervical Carcinoma	Concurrent altered expression in hgCIN and/or cervical carcinomas compared with normal cervical samples was shown for ATP13A3, HES1, OPA1, HRASLS, EYA2, ZMYND8, APOBEC2, and NCR2. Gene silencing of EYA2 significantly reduced viability, migratory capacity, and anchorage-independent growth of HPV16-transformed keratinocytes.
19950702	overexpression	Lung Adenocarcinoma	EYA2 expression was significantly up-regulated in adenocarcinoma, while not changed in lung squamous cell carcinoma.
15705892	overexpression	Malignant Ovarian Neoplasm	EYA2 mRNA was found to be up-regulated in ovarian cancer by real-time reverse transcription-PCR, whereas its protein product was detected in 93.6% of ovarian cancer specimens by immunohistochemistry (n = 140).
12039049	overexpression	Neuroblastoma	Interestingly, EYA2 was expressed in several neuroblastoma cell lines as four distinct transcripts having alternative 5'-ends, whereas only one EYA2 transcript was expressed in the normal human eye.
28416638	overexpression	Acute Myeloid Leukemia	Interestingly, cancer outlier profile analysis of human samples of acute myeloid leukemia (AML) in The Cancer Genome Atlas (TCGA) revealed a subtype of AML that strongly expressed EYA2. In addition, gene set enrichment analysis of human AML samples, including TCGA data, showed that this subtype of AML was more closely associated with the properties of leukemic stem cells in its gene expression signature than other AMLs.

Summary
Symbol	EYA2
Name	EYA transcriptional coactivator and phosphatase 2
Aliases	EAB1; eyes absent (Drosophila) homolog 2; eyes absent homolog 2 (Drosophila); Eyes absent homolog 2
Location	20q13.12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

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Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.092	0.0646	3.2	36.9	59.9	Gain
BRCA	Breast invasive carcinoma	1075	0.055	0.0728	5.6	48.9	45.5	Gain
CESC	Cervical and endocervical cancers	292	0.171	0.00337	6.2	54.8	39	Gain
COAD	Colon adenocarcinoma	449	0.138	0.00329	0	27.6	72.4	Gain
ESCA	Esophageal carcinoma	183	-0.006	0.94	2.7	32.8	64.5	Gain
GBM	Glioblastoma multiforme	147	0.383	1.73e-06	2	61.2	36.7	Gain
HNSC	Head and Neck squamous cell carcinoma	514	-0.073	0.1	6.4	55.8	37.7	Gain
KIRC	Kidney renal clear cell carcinoma	525	0.218	4.54e-07	0	77.1	22.9	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.042	0.474	0.3	64.6	35.1	Gain
LGG	Brain Lower Grade Glioma	513	0.285	4.86e-11	1.4	90.1	8.6	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.013	0.802	3.6	64.6	31.9	Neutral
LUAD	Lung adenocarcinoma	512	0.175	7.15e-05	14.5	43.4	42.2	Gain
LUSC	Lung squamous cell carcinoma	498	0.164	0.000242	10	37.8	52.2	Gain
OV	Ovarian serous cystadenocarcinoma	300	0.187	0.00115	5	28	67	Gain
PAAD	Pancreatic adenocarcinoma	177	-0.272	0.000245	2.3	72.3	25.4	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	-0.221	0.00462	2.5	91.4	6.2	Neutral
PRAD	Prostate adenocarcinoma	491	0.159	0.000415	2.4	89.8	7.7	Neutral
READ	Rectum adenocarcinoma	164	-0.072	0.36	0	11	89	Gain
SARC	Sarcoma	255	0.124	0.0488	5.9	55.7	38.4	Gain
SKCM	Skin Cutaneous Melanoma	367	-0.024	0.653	1.9	47.7	50.4	Gain
STAD	Stomach adenocarcinoma	413	0.073	0.14	0.5	32.7	66.8	Gain
TGCT	Testicular Germ Cell Tumors	150	0.226	0.00548	8	63.3	28.7	Neutral
THCA	Thyroid carcinoma	497	0.056	0.214	0	97.6	2.4	Neutral
THYM	Thymoma	119	0.168	0.0682	0.8	90.8	8.4	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	-0.073	0.0913	2.8	69.6	27.6	Neutral

Summary
Symbol	EYA2
Name	EYA transcriptional coactivator and phosphatase 2
Aliases	EAB1; eyes absent (Drosophila) homolog 2; eyes absent homolog 2 (Drosophila); Eyes absent homolog 2
Location	20q13.12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.408	0	17	408	-0.008	0.0101	NS/NA
BRCA	Breast invasive carcinoma	-0.371	0	83	785	0.028	1.08e-20	NS/NA
CESC	Cervical and endocervical cancers	-0.633	0	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.361	4.97e-11	19	297	0.194	1.21e-33	NS/NA
ESCA	Esophageal carcinoma	-0.366	1.9e-07	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.581	6.68e-07	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.497	0	20	522	0.026	2.31e-39	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.067	0.214	24	319	-0.001	5.38e-05	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.411	1.58e-13	23	275	0.001	0.000922	NS/NA
LGG	Brain Lower Grade Glioma	-0.506	0	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.15	0.00229	41	373	0.022	1.37e-17	NS/NA
LUAD	Lung adenocarcinoma	-0.417	0	21	456	0.021	2.97e-05	NS/NA
LUSC	Lung squamous cell carcinoma	-0.47	0	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.7	0.0433	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.337	3.49e-06	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	0.04	0.587	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.538	0	35	498	0.011	2.73e-07	NS/NA
READ	Rectum adenocarcinoma	-0.371	0.000147	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.421	1.22e-12	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	0.055	0.234	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.502	0	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.466	1.39e-09	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.63	0	50	509	0.158	1.5e-12	NS/NA
THYM	Thymoma	-0.502	6.09e-09	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.732	0	34	431	-0.171	1.32e-06	NS/NA

Summary
Symbol	EYA2
Name	EYA transcriptional coactivator and phosphatase 2
Aliases	EAB1; eyes absent (Drosophila) homolog 2; eyes absent homolog 2 (Drosophila); Eyes absent homolog 2
Location	20q13.12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	3	High
Appendix	3	High
Bone marrow	3	High
Breast	3	High
Bronchus	3	High
Caudate	2	Medium
Cerebellum	3	High
Cerebral cortex	3	High
Cervix, uterine	3	High
Colon	3	High
Duodenum	3	High
Endometrium	3	High
Epididymis	3	High
Esophagus	3	High
Fallopian tube	3	High
Gallbladder	3	High
Heart muscle	2	Medium
Hippocampus	3	High
Kidney	3	High
Liver	2	Medium
Lung	3	High
Lymph node	3	High
Nasopharynx	3	High
Oral mucosa	3	High
Ovary	3	High
Pancreas	3	High
Parathyroid gland	3	High
Placenta	3	High
Prostate	3	High
Rectum	3	High
Salivary gland	3	High
Seminal vesicle	3	High
Skeletal muscle	2	Medium
Skin	3	High
Small intestine	3	High
Smooth muscle	3	High
Soft tissue	3	High
Spleen	3	High
Stomach	3	High
Testis	3	High
Thyroid gland	3	High
Tonsil	3	High
Urinary bladder	3	High
Vagina	3	High

Summary
Symbol	EYA2
Name	EYA transcriptional coactivator and phosphatase 2
Aliases	EAB1; eyes absent (Drosophila) homolog 2; eyes absent homolog 2 (Drosophila); Eyes absent homolog 2
Location	20q13.12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.611	NS	24476821
BRCA	Breast invasive carcinoma	521	0.00032	Significant	23000897
COAD	Colon adenocarcinoma	149	0.113	NS	22810696
GBM	Glioblastoma multiforme	157	9.89e-09	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	1.35e-24	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.514	NS	26536169
LGG	Brain Lower Grade Glioma	513	2.89e-27	Significant	26824661
LUAD	Lung adenocarcinoma	230	0.845	NS	25079552
LUSC	Lung squamous cell carcinoma	178	2.84e-06	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.00585	Significant	21720365
PRAD	Prostate adenocarcinoma	333	2.86e-08	Significant	26544944
READ	Rectum adenocarcinoma	67	0.061	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.134	NS	26091043
STAD	Stomach adenocarcinoma	277	2.12e-06	Significant	25079317
THCA	Thyroid carcinoma	391	5.29e-08	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	9.85e-08	Significant	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	1.046	0.827	NS
BRCA	Breast invasive carcinoma	1079	1.06	0.797	NS
CESC	Cervical and endocervical cancers	291	0.631	0.134	NS
COAD	Colon adenocarcinoma	439	1.032	0.92	NS
ESCA	Esophageal carcinoma	184	0.946	0.867	NS
GBM	Glioblastoma multiforme	158	0.869	0.57	NS
HNSC	Head and Neck squamous cell carcinoma	518	0.811	0.291	NS
KIRC	Kidney renal clear cell carcinoma	531	0.932	0.74	NS
KIRP	Kidney renal papillary cell carcinoma	287	0.404	0.0452	Longer
LGG	Brain Lower Grade Glioma	511	2.446	0.000194	Shorter
LIHC	Liver hepatocellular carcinoma	365	1.422	0.132	NS
LUAD	Lung adenocarcinoma	502	0.828	0.38	NS
LUSC	Lung squamous cell carcinoma	494	0.887	0.543	NS
OV	Ovarian serous cystadenocarcinoma	303	0.87	0.501	NS
PAAD	Pancreatic adenocarcinoma	177	1.306	0.365	NS
PCPG	Pheochromocytoma and Paraganglioma	179	0	0.169	NS
PRAD	Prostate adenocarcinoma	497	1.321	0.784	NS
READ	Rectum adenocarcinoma	159	1.929	0.239	NS
SARC	Sarcoma	259	1.141	0.647	NS
SKCM	Skin Cutaneous Melanoma	459	0.871	0.477	NS
STAD	Stomach adenocarcinoma	388	1.05	0.834	NS
TGCT	Testicular Germ Cell Tumors	134	1.035	0.981	NS
THCA	Thyroid carcinoma	500	2.457	0.17	NS
THYM	Thymoma	119	4.353	0.158	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	0.358	0.000491	Longer

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	0.013	0.787	NS
BRCA	Breast invasive carcinoma	1071	-0.01	0.742	NS
CESC	Cervical and endocervical cancers	167	0.033	0.672	NS
COAD	Colon adenocarcinoma	445	0.116	0.014	Higher
ESCA	Esophageal carcinoma	162	0.05	0.525	NS
HNSC	Head and Neck squamous cell carcinoma	448	-0.006	0.895	NS
KIRC	Kidney renal clear cell carcinoma	531	0.02	0.652	NS
KIRP	Kidney renal papillary cell carcinoma	260	-0.006	0.919	NS
LIHC	Liver hepatocellular carcinoma	347	0.046	0.395	NS
LUAD	Lung adenocarcinoma	507	-0.03	0.499	NS
LUSC	Lung squamous cell carcinoma	497	-0.066	0.144	NS
OV	Ovarian serous cystadenocarcinoma	302	0.089	0.122	NS
PAAD	Pancreatic adenocarcinoma	176	0.132	0.0801	NS
READ	Rectum adenocarcinoma	156	0.132	0.1	NS
SKCM	Skin Cutaneous Melanoma	410	0.046	0.353	NS
STAD	Stomach adenocarcinoma	392	0.087	0.0851	NS
TGCT	Testicular Germ Cell Tumors	81	0.261	0.0187	Higher
THCA	Thyroid carcinoma	499	0.014	0.75	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	-0.238	6.9e-08	Lower

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	0.02	0.743	NS
HNSC	Head and Neck squamous cell carcinoma	498	0.246	2.6e-08	Higher
KIRC	Kidney renal clear cell carcinoma	525	0.166	0.000131	Higher
LGG	Brain Lower Grade Glioma	514	-0.033	0.46	NS
LIHC	Liver hepatocellular carcinoma	366	-0.059	0.257	NS
OV	Ovarian serous cystadenocarcinoma	296	0.04	0.494	NS
PAAD	Pancreatic adenocarcinoma	176	0.112	0.139	NS
STAD	Stomach adenocarcinoma	406	-0.008	0.879	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	-0.354	3.56e-17	Lower

Summary
Symbol	EYA2
Name	EYA transcriptional coactivator and phosphatase 2
Aliases	EAB1; eyes absent (Drosophila) homolog 2; eyes absent homolog 2 (Drosophila); Eyes absent homolog 2
Location	20q13.12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	EYA2
Name	EYA transcriptional coactivator and phosphatase 2
Aliases	EAB1; eyes absent (Drosophila) homolog 2; eyes absent homolog 2 (Drosophila); Eyes absent homolog 2
Location	20q13.12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for EYA2.

Summary
Symbol	EYA2
Name	EYA transcriptional coactivator and phosphatase 2
Aliases	EAB1; eyes absent (Drosophila) homolog 2; eyes absent homolog 2 (Drosophila); Eyes absent homolog 2
Location	20q13.12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
26837415	Lung Adenocarcinoma	upstream	miR-30a	negative regulation	We demonstrated that EYA2 is a direct target of miR-30a by using the dual-luciferase reporter assay in A549 cells and showed that EYA2 protein levels are inversely correlated with miR-30a expression in A549 and BEAS-2B cells.
24508260	Breast Carcinoma	upstream	miR-30a	negative regulation	Here, we show that miR-30a represses Eya2 expression by binding to the 3'-untranslated region of Eya2.
28416638	Acute Myeloid Leukemia	upstream	PLZF-RARA; Plzf	positive regulation	Indeed, PLZF-RARA as well as Plzf rendered those cells immortalized through upregulation of Eya2.