CR2Cancer

Summary
Symbol	EYA4
Name	EYA transcriptional coactivator and phosphatase 4
Aliases	DFNA10; CMD1J; eyes absent (Drosophila) homolog 4; eyes absent homolog 4 (Drosophila); dJ78N10.1 (eyes absen ......
Location	6q23.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

[ TOP ]

Domain

Function

Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye (By similarity).

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification erase	Histone phosphorylation	H2AXY142ph	H2AXY142	#

> Gene Ontology [ TOP ]
Biological Process	GO:0006282 regulation of DNA repair GO:0006470 protein dephosphorylation GO:0007601 visual perception GO:0007605 sensory perception of sound GO:0016311 dephosphorylation GO:0016570 histone modification GO:0016576 histone dephosphorylation GO:0035335 peptidyl-tyrosine dephosphorylation GO:0038034 signal transduction in absence of ligand GO:0045739 positive regulation of DNA repair GO:0050953 sensory perception of light stimulus GO:0050954 sensory perception of mechanical stimulus GO:0051052 regulation of DNA metabolic process GO:0051054 positive regulation of DNA metabolic process GO:0097191 extrinsic apoptotic signaling pathway GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand GO:1901099 negative regulation of signal transduction in absence of ligand GO:2001020 regulation of response to DNA damage stimulus GO:2001022 positive regulation of response to DNA damage stimulus GO:2001233 regulation of apoptotic signaling pathway GO:2001234 negative regulation of apoptotic signaling pathway GO:2001236 regulation of extrinsic apoptotic signaling pathway GO:2001237 negative regulation of extrinsic apoptotic signaling pathway GO:2001239 regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
Molecular Function	GO:0004721 phosphoprotein phosphatase activity GO:0004725 protein tyrosine phosphatase activity GO:0016791 phosphatase activity GO:0042578 phosphoric ester hydrolase activity
Cellular Component	-

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-5693606: DNA Double Strand Break Response R-HSA-5693532: DNA Double-Strand Break Repair R-HSA-73894: DNA Repair R-HSA-5693565: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks

Summary
Symbol	EYA4
Name	EYA transcriptional coactivator and phosphatase 4
Aliases	DFNA10; CMD1J; eyes absent (Drosophila) homolog 4; eyes absent homolog 4 (Drosophila); dJ78N10.1 (eyes absen ......
Location	6q23.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM275029	c.887C>T	p.S296L	Substitution - Missense	Large_intestine
COSM215995	c.332C>T	p.T111M	Substitution - Missense	Central_nervous_system
COSM1073478	c.278-1G>C	p.?	Unknown	Endometrium
COSM4586236	c.242G>A	p.W81*	Substitution - Nonsense	Bone
COSM3174111	c.900C>T	p.A300A	Substitution - coding silent	Large_intestine
COSM1073480	c.431C>A	p.P144H	Substitution - Missense	Endometrium
COSM1073493	c.1670C>T	p.A557V	Substitution - Missense	Prostate
COSM3620826	c.1422G>A	p.G474G	Substitution - coding silent	Skin
COSM4519733	c.1025G>A	p.R342K	Substitution - Missense	Skin
COSM337164	c.88A>G	p.M30V	Substitution - Missense	Lung
COSM5553431	c.1279G>C	p.E427Q	Substitution - Missense	Prostate
COSM3732566	c.34-6T>G	p.?	Unknown	Stomach
COSM5590844	c.12C>T	p.S4S	Substitution - coding silent	Skin
COSM4425780	c.298A>C	p.T100P	Substitution - Missense	Oesophagus
COSM3697512	c.167C>A	p.S56Y	Substitution - Missense	Large_intestine
COSM5445082	c.773C>G	p.S258C	Substitution - Missense	Oesophagus
COSM3948045	c.686C>A	p.P229Q	Substitution - Missense	Lung
COSM5404405	c.789C>T	p.F263F	Substitution - coding silent	Skin
COSM302162	c.512G>A	p.G171E	Substitution - Missense	Central_nervous_system
COSM379400	c.876G>A	p.A292A	Substitution - coding silent	Lung
COSM5625987	c.802C>G	p.Q268E	Substitution - Missense	Oesophagus
COSM1620933	c.1502G>A	p.G501E	Substitution - Missense	Liver
COSM4188148	c.1769A>T	p.Q590L	Substitution - Missense	Kidney
COSM5678606	c.169A>G	p.N57D	Substitution - Missense	Soft_tissue
COSM5032250	c.1182G>T	p.K394N	Substitution - Missense	Oesophagus
COSM3858411	c.1238T>G	p.I413S	Substitution - Missense	Stomach
COSM4971505	c.1078_1083delCCCTCC	p.S361_P362delSP	Deletion - In frame	Central_nervous_system
COSM5746636	c.1839+2T>C	p.?	Unknown	Pancreas
COSM3728049	c.1259A>G	p.H420R	Substitution - Missense	Liver
COSM5955377	c.927delT	p.Y310fs*10	Deletion - Frameshift	Upper_aerodigestive_tract
COSM1698021	c.1236G>A	p.M412I	Substitution - Missense	Skin
COSM4524723	c.128G>A	p.G43E	Substitution - Missense	Skin
COSM1698025	c.1393C>T	p.L465F	Substitution - Missense	Skin
COSM1487231	c.570G>T	p.L190F	Substitution - Missense	Breast
COSM4761583	c.137A>T	p.D46V	Substitution - Missense	Stomach
COSM4169012	c.1831G>T	p.A611S	Substitution - Missense	Peritoneum
COSM1440574	c.350T>C	p.L117P	Substitution - Missense	Large_intestine
COSM4984241	c.1004C>G	p.P335R	Substitution - Missense	Oesophagus
COSM1073481	c.454C>A	p.L152I	Substitution - Missense	Endometrium
COSM396169	c.615G>T	p.E205D	Substitution - Missense	Lung
COSM1698027	c.1760G>A	p.R587Q	Substitution - Missense	Skin
COSM3620812	c.1012G>A	p.D338N	Substitution - Missense	Skin
COSM5651918	c.896C>G	p.T299R	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3366299	c.1113G>A	p.V371V	Substitution - coding silent	Kidney
COSM4564387	c.1166_1167GG>AA	p.G389E	Substitution - Missense	Skin
COSM5927411	c.640C>T	p.P214S	Substitution - Missense	Skin
COSM4901737	c.1717A>T	p.I573F	Substitution - Missense	Skin
COSM1754516	c.508T>C	p.S170P	Substitution - Missense	Urinary_tract
COSM1620933	c.1502G>A	p.G501E	Substitution - Missense	Liver
COSM215996	c.1643C>T	p.T548M	Substitution - Missense	Central_nervous_system
COSM4426801	c.1012delG	p.D338fs*66	Deletion - Frameshift	Oesophagus
COSM3941513	c.944C>G	p.S315C	Substitution - Missense	Oesophagus
COSM1754518	c.822A>T	p.T274T	Substitution - coding silent	Urinary_tract
COSM3620816	c.1079C>T	p.P360L	Substitution - Missense	Skin
COSM3374058	c.988C>A	p.Q330K	Substitution - Missense	Thyroid
COSM4682137	c.211G>A	p.E71K	Substitution - Missense	Large_intestine
COSM1073489	c.1484A>G	p.Y495C	Substitution - Missense	Endometrium
COSM1642872	c.961A>G	p.N321D	Substitution - Missense	Stomach
COSM4555342	c.650G>A	p.S217N	Substitution - Missense	Skin
COSM1073495	c.1912T>A	p.Y638N	Substitution - Missense	Endometrium
COSM3620796	c.648G>A	p.Q216Q	Substitution - coding silent	Skin
COSM5756751	c.91G>C	p.E31Q	Substitution - Missense	Large_intestine
COSM1196414	c.385G>C	p.G129R	Substitution - Missense	Lung
COSM280910	c.328G>T	p.A110S	Substitution - Missense	Large_intestine
COSM3430024	c.528C>T	p.A176A	Substitution - coding silent	Large_intestine
COSM3620814	c.1058G>A	p.G353E	Substitution - Missense	Skin
COSM3430022	c.39G>T	p.K13N	Substitution - Missense	Large_intestine
COSM1073481	c.454C>A	p.L152I	Substitution - Missense	Endometrium
COSM289873	c.815C>A	p.S272Y	Substitution - Missense	Large_intestine
COSM4972474	c.474A>C	p.Q158H	Substitution - Missense	Oesophagus
COSM3410597	c.1709T>C	p.I570T	Substitution - Missense	Central_nervous_system
COSM5346672	c.992G>T	p.S331I	Substitution - Missense	Urinary_tract
COSM167360	c.1231G>T	p.E411*	Substitution - Nonsense	Endometrium
COSM345804	c.1252G>A	p.D418N	Substitution - Missense	Lung
COSM4780441	c.1291C>A	p.Q431K	Substitution - Missense	Liver
COSM3620782	c.91G>A	p.E31K	Substitution - Missense	Skin
COSM3620810	c.994C>T	p.P332S	Substitution - Missense	Skin
COSM3620824	c.1421G>A	p.G474E	Substitution - Missense	Skin
COSM3994600	c.1897G>T	p.A633S	Substitution - Missense	Kidney
COSM5508066	c.1567G>C	p.D523H	Substitution - Missense	Biliary_tract
COSM6012489	c.1566A>C	p.T522T	Substitution - coding silent	Skin
COSM1205887	c.1885G>A	p.A629T	Substitution - Missense	Large_intestine
COSM3174171	c.1776T>A	p.F592L	Substitution - Missense	Large_intestine
COSM379400	c.876G>A	p.A292A	Substitution - coding silent	Endometrium
COSM3725371	c.579C>T	p.Y193Y	Substitution - coding silent	Oesophagus
COSM5895816	c.1617-2A>G	p.?	Unknown	Skin
COSM1073482	c.454C>G	p.L152V	Substitution - Missense	Endometrium
COSM5709868	c.811C>T	p.P271S	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3728049	c.1259A>G	p.H420R	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1073484	c.696C>T	p.G232G	Substitution - coding silent	Endometrium
COSM1196414	c.385G>C	p.G129R	Substitution - Missense	Lung
COSM3620832	c.1717A>C	p.I573L	Substitution - Missense	Skin
COSM3858405	c.529G>A	p.V177I	Substitution - Missense	Stomach
COSM740040	c.811C>G	p.P271A	Substitution - Missense	Lung
COSM3715319	c.1765A>G	p.M589V	Substitution - Missense	Upper_aerodigestive_tract
COSM3620798	c.781A>C	p.T261P	Substitution - Missense	Skin
COSM740043	c.540C>A	p.A180A	Substitution - coding silent	Lung
COSM3620808	c.970+1G>T	p.?	Unknown	Skin
COSM5061420	c.1759C>T	p.R587*	Substitution - Nonsense	Stomach
COSM5404403	c.767C>T	p.S256L	Substitution - Missense	Skin
COSM450526	c.329C>T	p.A110V	Substitution - Missense	Breast
COSM5650988	c.1626C>G	p.C542W	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM228090	c.16G>A	p.D6N	Substitution - Missense	Skin
COSM4829199	c.339A>G	p.G113G	Substitution - coding silent	Cervix
COSM4682139	c.466G>T	p.A156S	Substitution - Missense	Large_intestine
COSM3620820	c.1273G>A	p.D425N	Substitution - Missense	Skin
COSM3761491	c.829G>A	p.G277S	Substitution - Missense	Large_intestine
COSM5983947	c.591G>A	p.V197V	Substitution - coding silent	Upper_aerodigestive_tract
COSM3620806	c.953G>A	p.G318E	Substitution - Missense	Skin
COSM3858407	c.653G>A	p.G218D	Substitution - Missense	Stomach
COSM4682141	c.1149T>C	p.F383F	Substitution - coding silent	Large_intestine
COSM740045	c.63T>A	p.V21V	Substitution - coding silent	Lung
COSM1073487	c.996C>A	p.P332P	Substitution - coding silent	Endometrium
COSM5794824	c.412T>C	p.Y138H	Substitution - Missense	Breast
COSM1754520	c.1044G>A	p.G348G	Substitution - coding silent	Urinary_tract
COSM1698019	c.1231G>A	p.E411K	Substitution - Missense	Skin
COSM1698015	c.755A>T	p.Y252F	Substitution - Missense	Skin
COSM5709866	c.304C>A	p.P102T	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3620786	c.134G>A	p.G45D	Substitution - Missense	Skin
COSM3829093	c.1671G>A	p.A557A	Substitution - coding silent	Breast
COSM3725371	c.579C>T	p.Y193Y	Substitution - coding silent	Lung
COSM3620794	c.509C>T	p.S170L	Substitution - Missense	Skin
COSM4451796	c.1414A>C	p.R472R	Substitution - coding silent	Skin
COSM3620822	c.1306G>A	p.D436N	Substitution - Missense	Skin
COSM374827	c.812C>A	p.P271Q	Substitution - Missense	Lung
COSM3858409	c.875C>T	p.A292V	Substitution - Missense	Oesophagus
COSM3715319	c.1765A>G	p.M589V	Substitution - Missense	Upper_aerodigestive_tract
COSM3858420	c.1855T>C	p.W619R	Substitution - Missense	Stomach
COSM3620830	c.1694G>A	p.G565E	Substitution - Missense	Skin
COSM3858417	c.1620T>C	p.S540S	Substitution - coding silent	Stomach
COSM1440572	c.306C>A	p.P102P	Substitution - coding silent	Large_intestine
COSM4404266	c.639C>T	p.S213S	Substitution - coding silent	Skin
COSM5176737	c.1223G>A	p.R408H	Substitution - Missense	Large_intestine
COSM3858403	c.484G>A	p.A162T	Substitution - Missense	Stomach
COSM33091	c.455T>G	p.L152R	Substitution - Missense	Large_intestine
COSM6007281	c.328G>A	p.A110T	Substitution - Missense	Prostate
COSM3620784	c.100G>A	p.D34N	Substitution - Missense	Skin
COSM3858418	c.1834A>G	p.K612E	Substitution - Missense	Stomach
COSM280911	c.1393C>A	p.L465I	Substitution - Missense	Large_intestine
COSM1754518	c.822A>T	p.T274T	Substitution - coding silent	Urinary_tract
COSM1637028	c.1327G>T	p.G443W	Substitution - Missense	Bone
COSM1698023	c.1313C>T	p.S438F	Substitution - Missense	Skin
COSM4645550	c.1727C>T	p.A576V	Substitution - Missense	Large_intestine
COSM320194	c.1571C>T	p.S524F	Substitution - Missense	Lung
COSM5509398	c.1815_1817delAGA	p.E608delE	Deletion - In frame	Biliary_tract
COSM1686526	c.1739-1G>A	p.?	Unknown	Skin
COSM3620788	c.152C>T	p.S51F	Substitution - Missense	Skin
COSM3769992	c.613G>T	p.E205*	Substitution - Nonsense	Soft_tissue
COSM5492138	c.1817A>G	p.E606G	Substitution - Missense	Biliary_tract
COSM740037	c.1324A>G	p.N442D	Substitution - Missense	Lung
COSM1440576	c.455T>C	p.L152P	Substitution - Missense	Stomach
COSM3858405	c.529G>A	p.V177I	Substitution - Missense	Prostate
COSM1487233	c.662G>A	p.S221N	Substitution - Missense	Breast
COSM3858409	c.875C>T	p.A292V	Substitution - Missense	Stomach
COSM215996	c.1643C>T	p.T548M	Substitution - Missense	Large_intestine
COSM1698021	c.1236G>A	p.M412I	Substitution - Missense	Skin
COSM5788614	c.69A>G	p.Q23Q	Substitution - coding silent	Breast
COSM3174115	c.978C>T	p.F326F	Substitution - coding silent	Breast
COSM1073479	c.428A>C	p.Y143S	Substitution - Missense	Endometrium
COSM4614028	c.212delA	p.N72fs*2	Deletion - Frameshift	Large_intestine
COSM740035	c.1865C>T	p.S622F	Substitution - Missense	Lung
COSM5895814	c.613G>A	p.E205K	Substitution - Missense	Skin
COSM5176737	c.1223G>A	p.R408H	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1754520	c.1044G>A	p.G348G	Substitution - coding silent	Urinary_tract
COSM1205885	c.1181A>C	p.K394T	Substitution - Missense	Large_intestine
COSM365863	c.48_49CA>TT	p.C16>?	Complex	Lung
COSM483420	c.1700C>T	p.A567V	Substitution - Missense	Kidney
COSM3662148	c.1754T>A	p.F585Y	Substitution - Missense	Liver
COSM1698021	c.1236G>A	p.M412I	Substitution - Missense	Skin
COSM33535	c.901G>A	p.D301N	Substitution - Missense	Large_intestine
COSM5698498	c.389A>T	p.Y130F	Substitution - Missense	Soft_tissue
COSM3829091	c.1025G>C	p.R342T	Substitution - Missense	Breast
COSM294356	c.790A>G	p.S264G	Substitution - Missense	Large_intestine
COSM1073487	c.996C>A	p.P332P	Substitution - coding silent	Stomach
COSM740043	c.540C>A	p.A180A	Substitution - coding silent	Soft_tissue
COSM1698021	c.1236G>A	p.M412I	Substitution - Missense	Skin
COSM1073493	c.1670C>T	p.A557V	Substitution - Missense	Large_intestine
COSM5645043	c.1528G>C	p.A510P	Substitution - Missense	Oesophagus
COSM3858413	c.1287T>G	p.C429W	Substitution - Missense	Stomach
COSM1698017	c.786T>A	p.N262K	Substitution - Missense	Skin
COSM1698019	c.1231G>A	p.E411K	Substitution - Missense	Skin
COSM3413911	c.1191+4A>C	p.?	Unknown	Oesophagus
COSM3620804	c.952G>A	p.G318R	Substitution - Missense	Skin
COSM3697514	c.199G>A	p.G67R	Substitution - Missense	Large_intestine
COSM740042	c.581-1G>C	p.?	Unknown	Lung
COSM1073483	c.566G>T	p.S189I	Substitution - Missense	Endometrium
COSM1073491	c.1576C>G	p.L526V	Substitution - Missense	Endometrium
COSM3620828	c.1519A>G	p.K507E	Substitution - Missense	Skin
COSM1440578	c.678C>T	p.F226F	Substitution - coding silent	Large_intestine
COSM4552249	c.553G>A	p.G185R	Substitution - Missense	Skin
COSM370217	c.205G>A	p.G69R	Substitution - Missense	Lung
COSM4519943	c.1035G>A	p.R345R	Substitution - coding silent	Skin
COSM5788145	c.970+5A>G	p.?	Unknown	Breast
COSM740039	c.972A>T	p.G324G	Substitution - coding silent	Lung
COSM3761491	c.829G>A	p.G277S	Substitution - Missense	Liver
COSM317302	c.49A>T	p.T17S	Substitution - Missense	Lung
COSM4333311	c.1246C>A	p.L416I	Substitution - Missense	Biliary_tract
COSM1440580	c.720G>T	p.M240I	Substitution - Missense	Large_intestine
COSM1698027	c.1760G>A	p.R587Q	Substitution - Missense	Skin
COSM5404412	c.1739G>A	p.G580E	Substitution - Missense	Skin
COSM5954436	c.1738+6G>C	p.?	Unknown	Upper_aerodigestive_tract
COSM3858398	c.223G>T	p.V75F	Substitution - Missense	Stomach
COSM275029	c.887C>T	p.S296L	Substitution - Missense	Endometrium
COSM3174125	c.1109G>A	p.R370H	Substitution - Missense	Oesophagus
COSM3662148	c.1754T>A	p.F585Y	Substitution - Missense	Liver
COSM5404411	c.1434G>A	p.M478I	Substitution - Missense	Skin
COSM4432239	c.1021G>T	p.E341*	Substitution - Nonsense	Oesophagus
COSM3174039	c.4G>A	p.E2K	Substitution - Missense	Skin
COSM3620818	c.1105G>A	p.E369K	Substitution - Missense	Skin
COSM3174079	c.375T>A	p.I125I	Substitution - coding silent	Large_intestine
COSM3620790	c.160G>A	p.E54K	Substitution - Missense	Skin
COSM740038	c.1222C>G	p.R408G	Substitution - Missense	Lung
COSM5918916	c.1122G>A	p.W374*	Substitution - Nonsense	Skin
COSM1311577	c.248T>C	p.L83P	Substitution - Missense	Urinary_tract
COSM1073492	c.1626C>A	p.C542*	Substitution - Nonsense	Endometrium
COSM4506106	c.710C>T	p.S237F	Substitution - Missense	Skin
COSM3620782	c.91G>A	p.E31K	Substitution - Missense	Skin
COSM3928095	c.438-2A>T	p.?	Unknown	Central_nervous_system
COSM3620820	c.1273G>A	p.D425N	Substitution - Missense	Skin
COSM1073490	c.1535T>C	p.L512P	Substitution - Missense	Endometrium
COSM5042883	c.356C>T	p.T119I	Substitution - Missense	Liver
COSM5912406	c.1091C>T	p.P364L	Substitution - Missense	Skin
COSM1073486	c.979G>A	p.D327N	Substitution - Missense	Endometrium
COSM5912408	c.1738+6G>A	p.?	Unknown	Skin
COSM33091	c.455T>G	p.L152R	Substitution - Missense	Stomach
COSM373251	c.1175C>A	p.A392E	Substitution - Missense	Lung
COSM3948047	c.1167G>A	p.G389G	Substitution - coding silent	Lung
COSM5451839	c.1374A>C	p.A458A	Substitution - coding silent	Large_intestine
COSM1319151	c.963C>A	p.N321K	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3858415	c.1501+2T>C	p.?	Unknown	Stomach
COSM1329302	c.107C>G	p.A36G	Substitution - Missense	Ovary
COSM3858400	c.340G>A	p.D114N	Substitution - Missense	Stomach
COSM5756751	c.91G>C	p.E31Q	Substitution - Missense	Large_intestine
COSM3781547	c.1625G>T	p.C542F	Substitution - Missense	Pancreas
COSM5890202	c.606C>T	p.I202I	Substitution - coding silent	Skin
COSM6012491	c.1569T>C	p.D523D	Substitution - coding silent	Skin
COSM357048	c.1108C>T	p.R370C	Substitution - Missense	Lung
COSM1642874	c.1570T>C	p.S524P	Substitution - Missense	Stomach
COSM4996602	c.55T>A	p.S19T	Substitution - Missense	Upper_aerodigestive_tract
COSM376876	c.240C>T	p.D80D	Substitution - coding silent	Lung
COSM4682143	c.1425T>C	p.V475V	Substitution - coding silent	Large_intestine
COSM5673765	c.1902G>T	p.L634L	Substitution - coding silent	Soft_tissue
COSM2154642	c.867G>A	p.T289T	Substitution - coding silent	Central_nervous_system
COSM3620800	c.872G>A	p.G291E	Substitution - Missense	Skin
COSM3620780	c.71C>T	p.S24F	Substitution - Missense	Skin
COSM360239	c.193A>C	p.T65P	Substitution - Missense	Lung
COSM4586238	c.1248T>C	p.L416L	Substitution - coding silent	Bone
COSM317302	c.49A>T	p.T17S	Substitution - Missense	Soft_tissue
COSM3174041	c.15G>A	p.Q5Q	Substitution - coding silent	Skin
COSM1311579	c.267T>A	p.S89S	Substitution - coding silent	Urinary_tract
COSM1440583	c.903T>C	p.D301D	Substitution - coding silent	Large_intestine
COSM228090	c.16G>A	p.D6N	Substitution - Missense	Skin
COSM1073481	c.454C>A	p.L152I	Substitution - Missense	Endometrium
COSM4773652	c.880A>T	p.M294L	Substitution - Missense	Stomach
COSM4775623	c.1015C>T	p.L339F	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1073488	c.1132G>T	p.E378*	Substitution - Nonsense	Endometrium
COSM1073485	c.949C>T	p.P317S	Substitution - Missense	Endometrium
COSM4941174	c.1744G>A	p.E582K	Substitution - Missense	Liver
COSM5578517	c.1255A>C	p.T419P	Substitution - Missense	Skin
COSM3620800	c.872G>A	p.G291E	Substitution - Missense	Skin
COSM5404407	c.1068G>A	p.R356R	Substitution - coding silent	Skin
COSM5404407	c.1068G>A	p.R356R	Substitution - coding silent	Skin
COSM5404409	c.1192G>A	p.D398N	Substitution - Missense	Skin
COSM5737776	c.539C>T	p.A180V	Substitution - Missense	Small_intestine
COSM1754516	c.508T>C	p.S170P	Substitution - Missense	Urinary_tract
COSM740041	c.619G>C	p.G207R	Substitution - Missense	Lung
COSM5666092	c.371-3C>T	p.?	Unknown	Soft_tissue
COSM3174079	c.375T>A	p.I125I	Substitution - coding silent	Large_intestine
COSM228090	c.16G>A	p.D6N	Substitution - Missense	Skin
COSM1073493	c.1670C>T	p.A557V	Substitution - Missense	Endometrium
COSM3858405	c.529G>A	p.V177I	Substitution - Missense	Bone
COSM3920760	c.863C>T	p.S288L	Substitution - Missense	Skin
COSM3620802	c.948C>T	p.L316L	Substitution - coding silent	Skin
COSM1642872	c.961A>G	p.N321D	Substitution - Missense	Stomach
COSM33091	c.455T>G	p.L152R	Substitution - Missense	Stomach
COSM1440572	c.306C>A	p.P102P	Substitution - coding silent	Large_intestine
COSM1440585	c.1848G>T	p.M616I	Substitution - Missense	Large_intestine
COSM483421	c.1758A>G	p.E586E	Substitution - coding silent	Kidney
COSM740036	c.1595C>G	p.S532C	Substitution - Missense	Lung
COSM3620792	c.200G>A	p.G67E	Substitution - Missense	Skin
COSM3620790	c.160G>A	p.E54K	Substitution - Missense	Skin
COSM1205883	c.884C>T	p.T295I	Substitution - Missense	Large_intestine
COSM4528302	c.1525G>A	p.D509N	Substitution - Missense	Skin
COSM3174139	c.1300A>G	p.I434V	Substitution - Missense	Large_intestine
COSM3174103	c.699G>A	p.Q233Q	Substitution - coding silent	Oesophagus
COSM2154642	c.867G>A	p.T289T	Substitution - coding silent	Large_intestine
COSM3430026	c.1140C>A	p.I380I	Substitution - coding silent	Large_intestine
COSM5517119	c.445C>A	p.P149T	Substitution - Missense	Biliary_tract

> Text Mining based Variations [ TOP ]
There is no record for EYA4.

Summary
Symbol	EYA4
Name	EYA transcriptional coactivator and phosphatase 4
Aliases	DFNA10; CMD1J; eyes absent (Drosophila) homolog 4; eyes absent homolog 4 (Drosophila); dJ78N10.1 (eyes absen ......
Location	6q23.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

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Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
O95677	361	S	Phosphoserine	-	No	None detected

Summary
Symbol	EYA4
Name	EYA transcriptional coactivator and phosphatase 4
Aliases	DFNA10; CMD1J; eyes absent (Drosophila) homolog 4; eyes absent homolog 4 (Drosophila); dJ78N10.1 (eyes absen ......
Location	6q23.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	2.398	-0.593	-2.803	4.66e-07	Under
BRCA	Breast invasive carcinoma	112	1100	-0.654	-1.938	-1.511	1.03e-10	Under
CESC	Cervical and endocervical cancers	3	306	-0.661	-2.104	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	-1.975	-2.405	-0.639	0.0449	Under
ESCA	Esophageal carcinoma	11	185	1.334	0.19	-0.797	0.457	NS
GBM	Glioblastoma multiforme	5	166	1.001	2.965	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	0.942	-0.434	-1.392	0.000862	Under
KIRC	Kidney renal clear cell carcinoma	72	534	3.704	0.426	-3.937	1.61e-52	Under
KIRP	Kidney renal papillary cell carcinoma	32	291	3.429	-3.145	-6.527	3.39e-42	Under
LGG	Brain Lower Grade Glioma	0	530	NA	-0.694	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	-2.957	-5.271	-0.959	0.028	Under
LUAD	Lung adenocarcinoma	59	517	2.759	-0.354	-2.773	4.83e-21	Under
LUSC	Lung squamous cell carcinoma	51	501	2.838	0.606	-1.912	5.85e-09	Under
OV	Ovarian serous cystadenocarcinoma	0	307	NA	2.513	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	-0.629	-0.425	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	0.343	-1.918	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	3.472	1.95	-1.862	8.65e-18	Under
READ	Rectum adenocarcinoma	10	167	-0.842	-2.17	-1.329	0.0518	NS
SARC	Sarcoma	2	263	2.035	2.112	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	1.93	1.187	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	-0.667	-0.142	0.477	0.236	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	-1.67	NA	NA	NA
THCA	Thyroid carcinoma	59	509	2.021	-0.247	-1.967	1.23e-08	Under
THYM	Thymoma	2	120	4.279	4.746	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	0.29	-3.332	-3.097	1.46e-07	Under

> Cancer Cell Line Encyclopedia (CCLE)

[ TOP ]

Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	10.4
Autonomic ganglia	CHP212	6.5
Autonomic ganglia	IMR32	9.5
Autonomic ganglia	KELLY	8.8
Autonomic ganglia	KPNRTBM1	4.2
Autonomic ganglia	KPNSI9S	7.8
Autonomic ganglia	KPNYN	6
Autonomic ganglia	MHHNB11	8.4
Autonomic ganglia	NB1	7.8
Autonomic ganglia	NH6	7
Autonomic ganglia	SHSY5Y	4.1
Autonomic ganglia	SIMA	10.2
Autonomic ganglia	SKNAS	5
Autonomic ganglia	SKNBE2	6.6
Autonomic ganglia	SKNDZ	9.6
Autonomic ganglia	SKNFI	8.7
Autonomic ganglia	SKNSH	4.1
Biliary tract	HUCCT1	3.9
Biliary tract	HUH28	7.3
Biliary tract	SNU1079	4
Biliary tract	SNU1196	3.9
Biliary tract	SNU245	4
Biliary tract	SNU308	6.5
Biliary tract	SNU478	4.3
Bone	143B	7
Bone	A673	4.5
Bone	CADOES1	3.8
Bone	CAL78	6.8
Bone	G292CLONEA141B1	4.1
Bone	HOS	7.2
Bone	HS706T	4.3
Bone	HS737T	4.2
Bone	HS819T	5
Bone	HS821T	4.5
Bone	HS822T	5.1
Bone	HS863T	4.1
Bone	HS870T	6.1
Bone	HS888T	6.5
Bone	MG63	7.2
Bone	MHHES1	3.7
Bone	OUMS27	4
Bone	RDES	4.3
Bone	SJSA1	3.9
Bone	SKES1	5.7
Bone	SKNMC	7.3
Bone	SW1353	5.7
Bone	T173	4.7
Bone	TC71	5.7
Bone	U2OS	3.8
Breast	AU565	3.8
Breast	BT20	4
Breast	BT474	3.9
Breast	BT483	4
Breast	BT549	4.8
Breast	CAL120	3.7
Breast	CAL148	3.9
Breast	CAL51	8
Breast	CAL851	4.3
Breast	CAMA1	4.1
Breast	DU4475	4.2
Breast	EFM192A	4
Breast	EFM19	4
Breast	EVSAT	4.2
Breast	HCC1143	4
Breast	HCC1187	5.5
Breast	HCC1395	4.1
Breast	HCC1419	3.9
Breast	HCC1428	4.2
Breast	HCC1500	3.9
Breast	HCC1569	4.1
Breast	HCC1599	4.2
Breast	HCC1806	6.1
Breast	HCC1937	3.9
Breast	HCC1954	4
Breast	HCC202	3.9
Breast	HCC2157	4.1
Breast	HCC2218	4
Breast	HCC38	4.2
Breast	HCC70	3.9
Breast	HDQP1	4.4
Breast	HMC18	8.9
Breast	HS274T	3.9
Breast	HS281T	3.8
Breast	HS343T	3.9
Breast	HS578T	3.9
Breast	HS606T	4
Breast	HS739T	4
Breast	HS742T	3.8
Breast	JIMT1	4.1
Breast	KPL1	5.2
Breast	MCF7	3.9
Breast	MDAMB134VI	4.2
Breast	MDAMB157	7.9
Breast	MDAMB175VII	3.9
Breast	MDAMB231	4.8
Breast	MDAMB361	5.2
Breast	MDAMB415	4.2
Breast	MDAMB436	7.9
Breast	MDAMB453	3.8
Breast	MDAMB468	3.7
Breast	SKBR3	3.8
Breast	T47D	4
Breast	UACC812	4
Breast	UACC893	4.2
Breast	YMB1	4.1
Breast	ZR751	3.9
Breast	ZR7530	3.8
Central nervous system	1321N1	4.7
Central nervous system	42MGBA	3.7
Central nervous system	8MGBA	8.2
Central nervous system	A172	3.8
Central nervous system	AM38	5.9
Central nervous system	BECKER	3.8
Central nervous system	CAS1	7
Central nervous system	CCFSTTG1	6.8
Central nervous system	D283MED	3.9
Central nervous system	D341MED	3.8
Central nervous system	DAOY	8.1
Central nervous system	DBTRG05MG	6.9
Central nervous system	DKMG	4.8
Central nervous system	GAMG	7.5
Central nervous system	GB1	3.9
Central nervous system	GI1	7.1
Central nervous system	GMS10	5.6
Central nervous system	GOS3	7.3
Central nervous system	H4	8.9
Central nervous system	HS683	7.5
Central nervous system	KALS1	7
Central nervous system	KG1C	6.2
Central nervous system	KNS42	8.9
Central nervous system	KNS60	6
Central nervous system	KNS81	7.5
Central nervous system	KS1	3.9
Central nervous system	LN18	7.9
Central nervous system	LN229	4.8
Central nervous system	M059K	6.8
Central nervous system	MOGGCCM	8.4
Central nervous system	MOGGUVW	7.9
Central nervous system	NMCG1	7.5
Central nervous system	ONS76	7.7
Central nervous system	SF126	7.7
Central nervous system	SF295	8.5
Central nervous system	SNB19	8
Central nervous system	SNU1105	7.3
Central nervous system	SNU201	6.6
Central nervous system	SNU466	4.3
Central nervous system	SNU489	8.2
Central nervous system	SNU626	7.1
Central nervous system	SNU738	3.9
Central nervous system	SW1088	5.8
Central nervous system	SW1783	7
Central nervous system	T98G	8.9
Central nervous system	TM31	6.9
Central nervous system	U118MG	3.8
Central nervous system	U138MG	4
Central nervous system	U251MG	9.3
Central nervous system	U87MG	8.7
Central nervous system	YH13	4.1
Central nervous system	YKG1	6.7
Endometrium	AN3CA	4
Endometrium	COLO684	3.9
Endometrium	EFE184	7.7
Endometrium	EN	4.1
Endometrium	ESS1	6.5
Endometrium	HEC108	4
Endometrium	HEC151	4.1
Endometrium	HEC1A	4
Endometrium	HEC1B	4.8
Endometrium	HEC251	6.9
Endometrium	HEC265	4.2
Endometrium	HEC50B	4.7
Endometrium	HEC59	4.1
Endometrium	HEC6	3.9
Endometrium	ISHIKAWAHERAKLIO02ER	10
Endometrium	JHUEM1	4
Endometrium	JHUEM2	4.1
Endometrium	JHUEM3	4.7
Endometrium	KLE	8.8
Endometrium	MFE280	11.2
Endometrium	MFE296	4.1
Endometrium	MFE319	4.1
Endometrium	RL952	4.1
Endometrium	SNGM	3.8
Endometrium	SNU1077	7.6
Endometrium	SNU685	6.6
Endometrium	TEN	5.7
Haematopoietic and lymphoid	697	9.1
Haematopoietic and lymphoid	A3KAW	6.5
Haematopoietic and lymphoid	A4FUK	6.2
Haematopoietic and lymphoid	ALLSIL	4
Haematopoietic and lymphoid	AML193	3.9
Haematopoietic and lymphoid	AMO1	4.4
Haematopoietic and lymphoid	BCP1	8.5
Haematopoietic and lymphoid	BDCM	3.9
Haematopoietic and lymphoid	BL41	3.9
Haematopoietic and lymphoid	BL70	3.9
Haematopoietic and lymphoid	BV173	3.9
Haematopoietic and lymphoid	CA46	3.9
Haematopoietic and lymphoid	CI1	4
Haematopoietic and lymphoid	CMK115	4.1
Haematopoietic and lymphoid	CMK86	3.8
Haematopoietic and lymphoid	CMK	3.7
Haematopoietic and lymphoid	CMLT1	6
Haematopoietic and lymphoid	COLO775	5.9
Haematopoietic and lymphoid	DAUDI	3.9
Haematopoietic and lymphoid	DB	4.2
Haematopoietic and lymphoid	DEL	4
Haematopoietic and lymphoid	DND41	4
Haematopoietic and lymphoid	DOHH2	3.9
Haematopoietic and lymphoid	EB1	4.3
Haematopoietic and lymphoid	EB2	4
Haematopoietic and lymphoid	EHEB	4
Haematopoietic and lymphoid	EJM	4.1
Haematopoietic and lymphoid	EM2	4
Haematopoietic and lymphoid	EOL1	4
Haematopoietic and lymphoid	F36P	4
Haematopoietic and lymphoid	GA10	4.2
Haematopoietic and lymphoid	GDM1	4
Haematopoietic and lymphoid	GRANTA519	3.9
Haematopoietic and lymphoid	HDLM2	4
Haematopoietic and lymphoid	HDMYZ	5.2
Haematopoietic and lymphoid	HEL9217	4.2
Haematopoietic and lymphoid	HEL	4.3
Haematopoietic and lymphoid	HH	4.3
Haematopoietic and lymphoid	HL60	4.1
Haematopoietic and lymphoid	HPBALL	3.9
Haematopoietic and lymphoid	HS604T	4.2
Haematopoietic and lymphoid	HS611T	7.1
Haematopoietic and lymphoid	HS616T	4.3
Haematopoietic and lymphoid	HS751T	5.1
Haematopoietic and lymphoid	HT	4
Haematopoietic and lymphoid	HTK	7.1
Haematopoietic and lymphoid	HUNS1	4.2
Haematopoietic and lymphoid	HUT102	3.9
Haematopoietic and lymphoid	HUT78	4.1
Haematopoietic and lymphoid	JEKO1	4.9
Haematopoietic and lymphoid	JK1	4
Haematopoietic and lymphoid	JM1	5.3
Haematopoietic and lymphoid	JURKAT	4
Haematopoietic and lymphoid	JURLMK1	5.2
Haematopoietic and lymphoid	JVM2	4.1
Haematopoietic and lymphoid	JVM3	4.1
Haematopoietic and lymphoid	K562	4
Haematopoietic and lymphoid	KARPAS299	4.1
Haematopoietic and lymphoid	KARPAS422	4
Haematopoietic and lymphoid	KARPAS620	5.8
Haematopoietic and lymphoid	KASUMI1	3.8
Haematopoietic and lymphoid	KASUMI2	6.9
Haematopoietic and lymphoid	KASUMI6	3.8
Haematopoietic and lymphoid	KCL22	3.9
Haematopoietic and lymphoid	KE37	3.8
Haematopoietic and lymphoid	KE97	4.2
Haematopoietic and lymphoid	KG1	4.1
Haematopoietic and lymphoid	KHM1B	6.5
Haematopoietic and lymphoid	KIJK	4.3
Haematopoietic and lymphoid	KMH2	3.9
Haematopoietic and lymphoid	KMM1	6.3
Haematopoietic and lymphoid	KMS11	5.3
Haematopoietic and lymphoid	KMS12BM	4.1
Haematopoietic and lymphoid	KMS18	3.9
Haematopoietic and lymphoid	KMS20	4.7
Haematopoietic and lymphoid	KMS21BM	6.3
Haematopoietic and lymphoid	KMS26	4.4
Haematopoietic and lymphoid	KMS27	4.9
Haematopoietic and lymphoid	KMS28BM	3.9
Haematopoietic and lymphoid	KMS34	4.1
Haematopoietic and lymphoid	KO52	3.9
Haematopoietic and lymphoid	KOPN8	4.1
Haematopoietic and lymphoid	KU812	4
Haematopoietic and lymphoid	KYO1	3.6
Haematopoietic and lymphoid	L1236	4.5
Haematopoietic and lymphoid	L363	4.2
Haematopoietic and lymphoid	L428	5.5
Haematopoietic and lymphoid	L540	3.7
Haematopoietic and lymphoid	LAMA84	3.7
Haematopoietic and lymphoid	LOUCY	3.9
Haematopoietic and lymphoid	LP1	4
Haematopoietic and lymphoid	M07E	3.9
Haematopoietic and lymphoid	MC116	4.1
Haematopoietic and lymphoid	ME1	4.1
Haematopoietic and lymphoid	MEC1	3.8
Haematopoietic and lymphoid	MEC2	3.8
Haematopoietic and lymphoid	MEG01	4.2
Haematopoietic and lymphoid	MHHCALL2	4.2
Haematopoietic and lymphoid	MHHCALL3	5
Haematopoietic and lymphoid	MHHCALL4	3.9
Haematopoietic and lymphoid	MINO	3.8
Haematopoietic and lymphoid	MJ	3.9
Haematopoietic and lymphoid	MM1S	6.9
Haematopoietic and lymphoid	MOLM13	4.1
Haematopoietic and lymphoid	MOLM16	4
Haematopoietic and lymphoid	MOLM6	4.1
Haematopoietic and lymphoid	MOLP2	4.7
Haematopoietic and lymphoid	MOLP8	4.6
Haematopoietic and lymphoid	MOLT13	4
Haematopoietic and lymphoid	MOLT16	3.8
Haematopoietic and lymphoid	MOLT4	3.9
Haematopoietic and lymphoid	MONOMAC1	4
Haematopoietic and lymphoid	MONOMAC6	4
Haematopoietic and lymphoid	MOTN1	4.1
Haematopoietic and lymphoid	MUTZ5	4
Haematopoietic and lymphoid	MV411	3.7
Haematopoietic and lymphoid	NALM19	4.4
Haematopoietic and lymphoid	NALM1	3.7
Haematopoietic and lymphoid	NALM6	4.6
Haematopoietic and lymphoid	NAMALWA	3.8
Haematopoietic and lymphoid	NB4	3.8
Haematopoietic and lymphoid	NCIH929	5.1
Haematopoietic and lymphoid	NCO2	3.8
Haematopoietic and lymphoid	NOMO1	3.9
Haematopoietic and lymphoid	NUDHL1	3.8
Haematopoietic and lymphoid	NUDUL1	3.9
Haematopoietic and lymphoid	OCIAML2	3.7
Haematopoietic and lymphoid	OCIAML3	3.9
Haematopoietic and lymphoid	OCIAML5	3.7
Haematopoietic and lymphoid	OCILY10	4.2
Haematopoietic and lymphoid	OCILY19	3.8
Haematopoietic and lymphoid	OCILY3	4.4
Haematopoietic and lymphoid	OCIM1	4.3
Haematopoietic and lymphoid	OPM2	4
Haematopoietic and lymphoid	P12ICHIKAWA	3.9
Haematopoietic and lymphoid	P31FUJ	4.7
Haematopoietic and lymphoid	P3HR1	4.2
Haematopoietic and lymphoid	PCM6	3.8
Haematopoietic and lymphoid	PEER	3.9
Haematopoietic and lymphoid	PF382	4
Haematopoietic and lymphoid	PFEIFFER	4.1
Haematopoietic and lymphoid	PL21	4
Haematopoietic and lymphoid	RAJI	4
Haematopoietic and lymphoid	RCHACV	7.5
Haematopoietic and lymphoid	REC1	7.6
Haematopoietic and lymphoid	REH	4.2
Haematopoietic and lymphoid	RI1	4
Haematopoietic and lymphoid	RL	4
Haematopoietic and lymphoid	RPMI8226	4
Haematopoietic and lymphoid	RPMI8402	3.9
Haematopoietic and lymphoid	RS411	6.3
Haematopoietic and lymphoid	SEM	5.2
Haematopoietic and lymphoid	SET2	3.9
Haematopoietic and lymphoid	SIGM5	4
Haematopoietic and lymphoid	SKM1	7
Haematopoietic and lymphoid	SKMM2	3.9
Haematopoietic and lymphoid	SR786	4.1
Haematopoietic and lymphoid	ST486	4.3
Haematopoietic and lymphoid	SUDHL10	3.9
Haematopoietic and lymphoid	SUDHL1	4.2
Haematopoietic and lymphoid	SUDHL4	4.2
Haematopoietic and lymphoid	SUDHL5	3.8
Haematopoietic and lymphoid	SUDHL6	4.1
Haematopoietic and lymphoid	SUDHL8	4.1
Haematopoietic and lymphoid	SUPB15	4
Haematopoietic and lymphoid	SUPHD1	3.9
Haematopoietic and lymphoid	SUPM2	4.7
Haematopoietic and lymphoid	SUPT11	4
Haematopoietic and lymphoid	SUPT1	4.4
Haematopoietic and lymphoid	TALL1	3.9
Haematopoietic and lymphoid	TF1	3.8
Haematopoietic and lymphoid	THP1	4
Haematopoietic and lymphoid	TO175T	4.4
Haematopoietic and lymphoid	TOLEDO	4
Haematopoietic and lymphoid	U266B1	5.4
Haematopoietic and lymphoid	U937	4
Haematopoietic and lymphoid	UT7	3.9
Haematopoietic and lymphoid	WSUDLCL2	4.2
Kidney	769P	4.2
Kidney	786O	4
Kidney	A498	5.4
Kidney	A704	4
Kidney	ACHN	3.9
Kidney	BFTC909	7.9
Kidney	CAKI1	6.4
Kidney	CAKI2	3.8
Kidney	CAL54	4.1
Kidney	KMRC1	4.2
Kidney	KMRC20	4.6
Kidney	KMRC2	4.1
Kidney	KMRC3	4
Kidney	OSRC2	3.8
Kidney	RCC10RGB	4
Kidney	SNU1272	3.9
Kidney	SNU349	3.9
Kidney	TUHR10TKB	3.7
Kidney	TUHR14TKB	4
Kidney	TUHR4TKB	3.9
Kidney	VMRCRCW	4.1
Kidney	VMRCRCZ	4
Large intestine	C2BBE1	4.2
Large intestine	CCK81	4.3
Large intestine	CL11	3.8
Large intestine	CL14	3.7
Large intestine	CL34	4
Large intestine	CL40	4
Large intestine	COLO205	4
Large intestine	COLO320	7.2
Large intestine	COLO678	4.2
Large intestine	CW2	3.9
Large intestine	DLD1	4
Large intestine	GP2D	4.4
Large intestine	HCC56	3.9
Large intestine	HCT116	3.9
Large intestine	HCT15	3.8
Large intestine	HS675T	8
Large intestine	HS698T	3.9
Large intestine	HT115	3.9
Large intestine	HT29	4.1
Large intestine	HT55	3.8
Large intestine	KM12	4.2
Large intestine	LOVO	3.9
Large intestine	LS1034	4
Large intestine	LS123	3.8
Large intestine	LS180	4
Large intestine	LS411N	4
Large intestine	LS513	3.8
Large intestine	MDST8	4.5
Large intestine	NCIH508	4
Large intestine	NCIH716	4.1
Large intestine	NCIH747	3.8
Large intestine	OUMS23	4.1
Large intestine	RCM1	4.5
Large intestine	RKO	4
Large intestine	SKCO1	4
Large intestine	SNU1040	4.1
Large intestine	SNU1197	3.8
Large intestine	SNU175	4.2
Large intestine	SNU283	4.2
Large intestine	SNU407	4
Large intestine	SNU503	4.3
Large intestine	SNU61	3.8
Large intestine	SNU81	4
Large intestine	SNUC1	4.4
Large intestine	SNUC2A	4
Large intestine	SNUC4	4
Large intestine	SNUC5	4
Large intestine	SW1116	4.1
Large intestine	SW1417	3.9
Large intestine	SW1463	4.2
Large intestine	SW403	3.8
Large intestine	SW480	4.1
Large intestine	SW48	3.9
Large intestine	SW620	4.9
Large intestine	SW837	4.4
Large intestine	SW948	3.7
Large intestine	T84	4
Liver	ALEXANDERCELLS	4.3
Liver	C3A	4.2
Liver	HEP3B217	3.9
Liver	HEPG2	3.9
Liver	HLE	6.3
Liver	HLF	6.1
Liver	HUH1	4.3
Liver	HUH6	3.9
Liver	HUH7	6.3
Liver	JHH1	7.3
Liver	JHH2	4.2
Liver	JHH4	3.9
Liver	JHH5	4.9
Liver	JHH6	3.9
Liver	JHH7	4.7
Liver	LI7	3.7
Liver	PLCPRF5	7.3
Liver	SKHEP1	6.3
Liver	SNU182	6.2
Liver	SNU387	4.7
Liver	SNU398	7
Liver	SNU423	5.9
Liver	SNU449	4.3
Liver	SNU475	9.2
Liver	SNU761	3.9
Liver	SNU878	8.5
Liver	SNU886	5.1
Lung	A549	6.3
Lung	ABC1	7.4
Lung	BEN	5.7
Lung	CAL12T	5.6
Lung	CALU1	4.3
Lung	CALU3	8.5
Lung	CALU6	4.1
Lung	CHAGOK1	9
Lung	COLO668	4
Lung	COLO699	7.1
Lung	CORL105	3.8
Lung	CORL23	4.1
Lung	CORL24	9.8
Lung	CORL279	9
Lung	CORL311	4
Lung	CORL47	5.9
Lung	CORL51	4.6
Lung	CORL88	3.8
Lung	CORL95	7.4
Lung	CPCN	9.6
Lung	DMS114	4.1
Lung	DMS153	5
Lung	DMS273	7.2
Lung	DMS454	4.2
Lung	DMS53	5.8
Lung	DMS79	3.9
Lung	DV90	4.6
Lung	EBC1	3.7
Lung	EPLC272H	4.2
Lung	HARA	7.1
Lung	HCC1171	5.2
Lung	HCC1195	4.2
Lung	HCC15	7.5
Lung	HCC2279	4
Lung	HCC2935	4.2
Lung	HCC33	8.9
Lung	HCC366	6.5
Lung	HCC4006	4.3
Lung	HCC44	3.9
Lung	HCC78	5
Lung	HCC827	3.8
Lung	HCC95	6.3
Lung	HLC1	4.1
Lung	HLFA	7.1
Lung	HS229T	4.3
Lung	HS618T	5.8
Lung	IALM	4
Lung	KNS62	7.8
Lung	LC1F	4.8
Lung	LC1SQSF	5.9
Lung	LCLC103H	5.3
Lung	LCLC97TM1	4
Lung	LK2	4.6
Lung	LOUNH91	4.1
Lung	LU65	8.4
Lung	LU99	8
Lung	LUDLU1	8.3
Lung	LXF289	8.7
Lung	MORCPR	5.8
Lung	NCIH1048	6.3
Lung	NCIH1092	8.5
Lung	NCIH1105	4
Lung	NCIH1155	5.5
Lung	NCIH1184	9
Lung	NCIH1299	6.4
Lung	NCIH1339	7.9
Lung	NCIH1341	7.7
Lung	NCIH1355	6.1
Lung	NCIH1373	4.1
Lung	NCIH1385	6.6
Lung	NCIH1395	4.2
Lung	NCIH1435	4.2
Lung	NCIH1436	5.4
Lung	NCIH1437	6.1
Lung	NCIH146	6.5
Lung	NCIH1563	7
Lung	NCIH1568	4.1
Lung	NCIH1573	4.5
Lung	NCIH1581	5.4
Lung	NCIH1618	4.7
Lung	NCIH1623	4.5
Lung	NCIH1648	6.9
Lung	NCIH1650	6.4
Lung	NCIH1651	8.4
Lung	NCIH1666	5.5
Lung	NCIH1693	8
Lung	NCIH1694	3.9
Lung	NCIH1703	4.4
Lung	NCIH1734	8.9
Lung	NCIH1755	7.3
Lung	NCIH1781	6.6
Lung	NCIH1792	8.4
Lung	NCIH1793	7.7
Lung	NCIH1836	4.2
Lung	NCIH1838	4
Lung	NCIH1869	4
Lung	NCIH1876	8.5
Lung	NCIH1915	8.7
Lung	NCIH1930	5.2
Lung	NCIH1944	8
Lung	NCIH1963	9.3
Lung	NCIH196	5.6
Lung	NCIH1975	3.9
Lung	NCIH2009	5.9
Lung	NCIH2023	8
Lung	NCIH2029	4
Lung	NCIH2030	8.4
Lung	NCIH2066	5.6
Lung	NCIH2081	8.4
Lung	NCIH2085	4.5
Lung	NCIH2087	4
Lung	NCIH209	4.4
Lung	NCIH2106	8.3
Lung	NCIH2110	4.4
Lung	NCIH211	5.8
Lung	NCIH2122	4.1
Lung	NCIH2126	5.1
Lung	NCIH2141	7.1
Lung	NCIH2170	9.1
Lung	NCIH2171	4.1
Lung	NCIH2172	5.3
Lung	NCIH2196	10.5
Lung	NCIH2227	3.8
Lung	NCIH2228	7.5
Lung	NCIH226	5.3
Lung	NCIH2286	4.6
Lung	NCIH2291	4
Lung	NCIH2342	3.8
Lung	NCIH2347	4.1
Lung	NCIH23	5
Lung	NCIH2405	3.8
Lung	NCIH2444	4
Lung	NCIH292	3.7
Lung	NCIH322	6.1
Lung	NCIH3255	5
Lung	NCIH358	4.2
Lung	NCIH441	4.1
Lung	NCIH446	8.6
Lung	NCIH460	7.7
Lung	NCIH510	3.8
Lung	NCIH520	4
Lung	NCIH522	3.8
Lung	NCIH524	4.2
Lung	NCIH526	4.9
Lung	NCIH596	6.3
Lung	NCIH647	8.4
Lung	NCIH650	4
Lung	NCIH661	3.8
Lung	NCIH69	4.4
Lung	NCIH727	4.4
Lung	NCIH810	5.7
Lung	NCIH82	3.8
Lung	NCIH838	8.7
Lung	NCIH841	5.9
Lung	NCIH854	5.1
Lung	NCIH889	7.2
Lung	PC14	6.1
Lung	RERFLCAD1	3.8
Lung	RERFLCAD2	4.8
Lung	RERFLCAI	4
Lung	RERFLCKJ	4.3
Lung	RERFLCMS	8.1
Lung	RERFLCSQ1	6.4
Lung	SBC5	8.9
Lung	SCLC21H	6.1
Lung	SHP77	4.1
Lung	SKLU1	6
Lung	SKMES1	4.7
Lung	SQ1	4.1
Lung	SW1271	7
Lung	SW1573	4
Lung	SW900	5.8
Lung	VMRCLCD	7.4
Lung	VMRCLCP	7.8
Oesophagus	COLO680N	3.9
Oesophagus	ECGI10	7.9
Oesophagus	KYSE140	4
Oesophagus	KYSE150	4.5
Oesophagus	KYSE180	4
Oesophagus	KYSE270	4.2
Oesophagus	KYSE30	8.9
Oesophagus	KYSE410	5
Oesophagus	KYSE450	6.3
Oesophagus	KYSE510	4.1
Oesophagus	KYSE520	4.3
Oesophagus	KYSE70	6.4
Oesophagus	OE19	4.1
Oesophagus	OE33	4.3
Oesophagus	TE10	4.5
Oesophagus	TE11	3.7
Oesophagus	TE14	5
Oesophagus	TE15	4.1
Oesophagus	TE1	4.2
Oesophagus	TE4	5.7
Oesophagus	TE5	3.9
Oesophagus	TE6	4.2
Oesophagus	TE8	4.4
Oesophagus	TE9	5
Oesophagus	TT	4
Ovary	59M	8.8
Ovary	A2780	8.2
Ovary	CAOV3	6.5
Ovary	CAOV4	8.2
Ovary	COLO704	3.9
Ovary	COV318	9.6
Ovary	COV362	5.4
Ovary	COV434	3.9
Ovary	COV504	7.4
Ovary	COV644	9
Ovary	EFO21	9.4
Ovary	EFO27	4
Ovary	ES2	6.4
Ovary	FUOV1	6.6
Ovary	HEYA8	7.3
Ovary	HS571T	4
Ovary	IGROV1	4.1
Ovary	JHOC5	6.6
Ovary	JHOM1	7.8
Ovary	JHOM2B	3.9
Ovary	JHOS2	6.4
Ovary	JHOS4	7.2
Ovary	KURAMOCHI	10.3
Ovary	MCAS	4.2
Ovary	NIHOVCAR3	8.3
Ovary	OAW28	8.7
Ovary	OAW42	5.7
Ovary	OC314	6.6
Ovary	OC316	5.6
Ovary	ONCODG1	8.3
Ovary	OV56	3.9
Ovary	OV7	6.8
Ovary	OV90	4.1
Ovary	OVCAR4	8.6
Ovary	OVCAR8	5.9
Ovary	OVISE	4.2
Ovary	OVK18	3.8
Ovary	OVKATE	3.9
Ovary	OVMANA	3.9
Ovary	OVSAHO	8.4
Ovary	OVTOKO	4.7
Ovary	RMGI	4.7
Ovary	RMUGS	7.4
Ovary	SKOV3	7.8
Ovary	SNU119	7.9
Ovary	SNU840	4.4
Ovary	SNU8	8.5
Ovary	TOV112D	5.6
Ovary	TOV21G	4.1
Ovary	TYKNU	3.9
Pancreas	ASPC1	3.8
Pancreas	BXPC3	4.9
Pancreas	CAPAN1	3.8
Pancreas	CAPAN2	3.9
Pancreas	CFPAC1	7
Pancreas	DANG	4.3
Pancreas	HPAC	4.1
Pancreas	HPAFII	4.1
Pancreas	HS766T	4
Pancreas	HUPT3	3.9
Pancreas	HUPT4	4.2
Pancreas	KCIMOH1	4.3
Pancreas	KLM1	3.7
Pancreas	KP2	4.1
Pancreas	KP3	4.7
Pancreas	KP4	3.9
Pancreas	L33	8.1
Pancreas	MIAPACA2	3.7
Pancreas	PANC0203	4.1
Pancreas	PANC0213	3.6
Pancreas	PANC0327	5.4
Pancreas	PANC0403	4.1
Pancreas	PANC0504	3.8
Pancreas	PANC0813	4.8
Pancreas	PANC1005	3.8
Pancreas	PANC1	3.9
Pancreas	PATU8902	3.8
Pancreas	PATU8988S	4
Pancreas	PATU8988T	4
Pancreas	PK1	3.7
Pancreas	PK45H	3.9
Pancreas	PK59	4
Pancreas	PL45	3.8
Pancreas	PSN1	3.9
Pancreas	QGP1	4.1
Pancreas	SNU213	3.8
Pancreas	SNU324	3.9
Pancreas	SNU410	3.9
Pancreas	SU8686	8
Pancreas	SUIT2	6.9
Pancreas	SW1990	3.7
Pancreas	T3M4	6.6
Pancreas	TCCPAN2	4.2
Pancreas	YAPC	4
Pleura	ACCMESO1	4
Pleura	DM3	5.4
Pleura	ISTMES1	5.6
Pleura	ISTMES2	4.1
Pleura	JL1	4.9
Pleura	MPP89	6
Pleura	MSTO211H	7.3
Pleura	NCIH2052	4.5
Pleura	NCIH2452	5
Pleura	NCIH28	4.1
Prostate	22RV1	3.9
Prostate	DU145	3.8
Prostate	LNCAPCLONEFGC	3.8
Prostate	MDAPCA2B	3.8
Prostate	NCIH660	4.1
Prostate	PC3	6.7
Prostate	VCAP	3.9
Salivary gland	A253	3.8
Salivary gland	YD15	5.2
Skin	A101D	6.2
Skin	A2058	8.7
Skin	A375	8.2
Skin	C32	7.2
Skin	CHL1	4.9
Skin	CJM	3.8
Skin	COLO679	3.8
Skin	COLO741	8.3
Skin	COLO783	7
Skin	COLO792	5.6
Skin	COLO800	6.4
Skin	COLO818	7.4
Skin	COLO829	7.9
Skin	COLO849	9.1
Skin	G361	7.9
Skin	GRM	3.8
Skin	HMCB	5.4
Skin	HS294T	6.8
Skin	HS600T	4
Skin	HS688AT	4
Skin	HS695T	6.2
Skin	HS839T	4.7
Skin	HS852T	4.4
Skin	HS895T	5.2
Skin	HS934T	5.5
Skin	HS936T	6.7
Skin	HS939T	5
Skin	HS940T	4.4
Skin	HS944T	6.8
Skin	HT144	6.8
Skin	IGR1	7.1
Skin	IGR37	7.9
Skin	IGR39	5.6
Skin	IPC298	3.6
Skin	K029AX	6.9
Skin	LOXIMVI	6.3
Skin	MALME3M	5.9
Skin	MDAMB435S	4.6
Skin	MELHO	6.9
Skin	MELJUSO	7.7
Skin	MEWO	8.7
Skin	RPMI7951	3.9
Skin	RVH421	7.4
Skin	SH4	8.4
Skin	SKMEL1	6.4
Skin	SKMEL24	7.2
Skin	SKMEL28	9
Skin	SKMEL2	4
Skin	SKMEL30	5.8
Skin	SKMEL31	4.2
Skin	SKMEL3	6.5
Skin	SKMEL5	9.3
Skin	UACC257	7.1
Skin	UACC62	6.7
Skin	WM115	5.1
Skin	WM1799	8.3
Skin	WM2664	8.4
Skin	WM793	6.2
Skin	WM88	9.3
Skin	WM983B	6.3
Small intestine	HUTU80	4.3
Soft tissue	A204	3.9
Soft tissue	G401	4.2
Soft tissue	G402	11
Soft tissue	GCT	6.6
Soft tissue	HS729	7.5
Soft tissue	HT1080	6.1
Soft tissue	KYM1	3.9
Soft tissue	MESSA	10.2
Soft tissue	RD	8.2
Soft tissue	RH30	5.9
Soft tissue	RH41	8.8
Soft tissue	RKN	5.9
Soft tissue	S117	8.3
Soft tissue	SJRH30	8.8
Soft tissue	SKLMS1	6.1
Soft tissue	SKUT1	4.1
Soft tissue	TE125T	5.2
Soft tissue	TE159T	4.9
Soft tissue	TE441T	3.9
Soft tissue	TE617T	5.2
Stomach	2313287	4.3
Stomach	AGS	4
Stomach	AZ521	4
Stomach	ECC10	3.8
Stomach	ECC12	7.7
Stomach	FU97	4.1
Stomach	GCIY	4.1
Stomach	GSS	3.7
Stomach	GSU	3.7
Stomach	HGC27	8.3
Stomach	HS746T	3.8
Stomach	HUG1N	3.9
Stomach	IM95	4.4
Stomach	KATOIII	4
Stomach	KE39	4
Stomach	LMSU	5.3
Stomach	MKN1	3.9
Stomach	MKN45	3.8
Stomach	MKN74	4
Stomach	MKN7	4.2
Stomach	NCCSTCK140	4.7
Stomach	NCIN87	3.7
Stomach	NUGC2	4.1
Stomach	NUGC3	4.4
Stomach	NUGC4	3.9
Stomach	OCUM1	4.1
Stomach	RERFGC1B	7.6
Stomach	SH10TC	4.1
Stomach	SNU16	4.1
Stomach	SNU1	4
Stomach	SNU216	4.1
Stomach	SNU520	3.9
Stomach	SNU5	3.9
Stomach	SNU601	3.7
Stomach	SNU620	3.7
Stomach	SNU668	4.1
Stomach	SNU719	3.8
Stomach	TGBC11TKB	3.8
Thyroid	8305C	6.2
Thyroid	8505C	6.3
Thyroid	BCPAP	7.5
Thyroid	BHT101	8.2
Thyroid	CAL62	5.2
Thyroid	CGTHW1	5.5
Thyroid	FTC133	8.1
Thyroid	FTC238	7.4
Thyroid	ML1	8.2
Thyroid	SW579	5.3
Thyroid	TT2609C02	6.7
Thyroid	TT	4.1
Upper aerodigestive tract	BHY	4.1
Upper aerodigestive tract	BICR16	4.9
Upper aerodigestive tract	BICR18	5.2
Upper aerodigestive tract	BICR22	4.2
Upper aerodigestive tract	BICR31	5.9
Upper aerodigestive tract	BICR56	4.1
Upper aerodigestive tract	BICR6	4.1
Upper aerodigestive tract	CAL27	4.5
Upper aerodigestive tract	CAL33	3.6
Upper aerodigestive tract	DETROIT562	4.2
Upper aerodigestive tract	FADU	3.9
Upper aerodigestive tract	HS840T	4.2
Upper aerodigestive tract	HSC2	4
Upper aerodigestive tract	HSC3	4.1
Upper aerodigestive tract	HSC4	4.1
Upper aerodigestive tract	PECAPJ15	4.2
Upper aerodigestive tract	PECAPJ34CLONEC12	3.9
Upper aerodigestive tract	PECAPJ41CLONED2	4.1
Upper aerodigestive tract	PECAPJ49	3.9
Upper aerodigestive tract	SCC15	4
Upper aerodigestive tract	SCC25	4.1
Upper aerodigestive tract	SCC4	5.8
Upper aerodigestive tract	SCC9	4.4
Upper aerodigestive tract	SNU1076	5.9
Upper aerodigestive tract	SNU1214	3.8
Upper aerodigestive tract	SNU46	7.4
Upper aerodigestive tract	SNU899	6.3
Upper aerodigestive tract	YD10B	3.9
Upper aerodigestive tract	YD38	4.5
Upper aerodigestive tract	YD8	3.9
Urinary tract	5637	4.1
Urinary tract	639V	4
Urinary tract	647V	3.7
Urinary tract	BC3C	7
Urinary tract	BFTC905	6.4
Urinary tract	CAL29	3.9
Urinary tract	HS172T	5.9
Urinary tract	HT1197	4
Urinary tract	HT1376	3.9
Urinary tract	J82	4.4
Urinary tract	JMSU1	6.8
Urinary tract	KMBC2	3.9
Urinary tract	KU1919	4.1
Urinary tract	RT11284	3.9
Urinary tract	RT112	4
Urinary tract	RT4	5.3
Urinary tract	SCABER	5.1
Urinary tract	SW1710	4
Urinary tract	SW780	4
Urinary tract	T24	4.2
Urinary tract	TCCSUP	4
Urinary tract	UMUC1	3.8
Urinary tract	UMUC3	4.4
Urinary tract	VMCUB1	5.3

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	1.2
Adrenal gland	3.3
Appendix	0.1
Bone marrow	0
Breast	0.2
Cerebral cortex	0.9
Cervix, uterine	4.1
Colon	0.2
Duodenum	0.3
Endometrium	0.8
Epididymis	1.7
Esophagus	0.4
Fallopian tube	11.7
Gallbladder	0.8
Heart muscle	3.6
Kidney	5.8
Liver	0
Lung	2.6
Lymph node	0.1
Ovary	1.5
Pancreas	0
Parathyroid gland	0
Placenta	0.2
Prostate	9
Rectum	0.3
Salivary gland	0
Seminal vesicle	16.3
Skeletal muscle	9.1
Skin	0
Small intestine	0.2
Smooth muscle	0.5
Spleen	0.6
Stomach	0.4
Testis	5.5
Thyroid gland	3.4
Tonsil	0.4
Urinary bladder	2.6

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
27469137	underexpression	Intrahepatic Cholangiocarcinoma	ICC tissues had significantly lower EYA4 mRNA and protein levels compared with adjacent non-tumoral tissues (both P<0.001).
27231175	underexpression (hypermethylation)	Acute Myeloid Leukemia	EYA4 gene was hypermethylated in AML1-ETO+ patients and its expression was down-regulated by 6-fold in Kasumi-1 and SKNO-1 cells, compared to HL-60 and SKNO-1-siA/E cells, respectively.
27015871	hypermethylation; loss of expression	Oral Squamous Cell Carcinoma	We previously identified EYA4 as frequently hypermethylated and silenced in premalignant disease based on an analysis of lesion-adjacent normal, dysplasia, and carcinoma in situ/squamous cell carcinoma tissues from the oral cavity.
25620232	underexpression (hypermethylation)	Colorectal Carcinoma	We analyzed the EYA4 methylation status and found EYA4 promoter methylation in CRC cell lines (100%), CRC tissues (93.5%) and advanced adenoma tissues (50.7%), compared with normal mucosa (32.6%). There was a significant inverse correlation between EYA4 methylation and expression.
24306662	underexpression	Hepatocellular Carcinoma	EYA4 expression was inversely related to tumor size (P<0.050). Lower EYA4 expression and larger tumor size were independent predictors of both shorter DFS and OS, and higher Barcelona Clinic Liver Cancer (BCLC) staging was an independent predictor of shorter OS (all P<0.050).
24096489	loss of expression; hypermethylation; underexpression	Lung Carcinoma	EYA4 is frequently and concomitantly deleted, hypermethylated and underexpressed in multiple independent lung tumor data sets, in both major NSCLC subtypes and in the earliest stages of lung cancer.
22493696	underexpression (hypermethylation)	Acute Lymphoblastic Leukemia	Twenty of the differentially methylated genes were hypermethylated in the ALL cells, and as many as nine of them (AMICA1, CPNE7, CR1, DBC1, EYA4, LGALS8, RYR3, UQCRFS1, WDR35) have functions in cell signaling and/or apoptosis.
19939248	overexpression	Esophageal Squamous Cell Carcinoma	The hTERT and EYA4 mRNA positive expression increased according to disease severity.
15824152	underexpression (hypermethylation)	Esophageal Adenocarcinoma	EYA4 EYA4 hypermethylation was detected in 83% (33 of 40) of esophageal adenocarcinomas and 77% (27 of 35) of Barrett's tissues, but only in 3% (2 of 58) of normal esophageal and gastric mucosa samples (P < 0.001). The unmethylated cancer cell lines had much higher EYA4 mRNA expression than the methylated cancer cell lines.

Summary
Symbol	EYA4
Name	EYA transcriptional coactivator and phosphatase 4
Aliases	DFNA10; CMD1J; eyes absent (Drosophila) homolog 4; eyes absent homolog 4 (Drosophila); dJ78N10.1 (eyes absen ......
Location	6q23.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.071	0.152	43.6	46.5	9.9	Loss
BRCA	Breast invasive carcinoma	1075	0.067	0.0275	28.8	54.5	16.7	Neutral
CESC	Cervical and endocervical cancers	292	0.106	0.0714	28.8	62.3	8.9	Neutral
COAD	Colon adenocarcinoma	449	0.056	0.236	12.2	70.8	16.9	Neutral
ESCA	Esophageal carcinoma	183	-0.089	0.232	24.6	54.6	20.8	Neutral
GBM	Glioblastoma multiforme	147	0.112	0.176	36.1	61.2	2.7	Loss
HNSC	Head and Neck squamous cell carcinoma	514	0.072	0.103	15	72	13	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.103	0.0187	27.8	70.5	1.7	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.134	0.0227	10.4	87.8	1.7	Neutral
LGG	Brain Lower Grade Glioma	513	0.032	0.474	15.4	83.6	1	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.094	0.0719	35.2	53	11.8	Loss
LUAD	Lung adenocarcinoma	512	0.088	0.0471	48.4	42.6	9	Loss
LUSC	Lung squamous cell carcinoma	498	0.134	0.00279	24.3	55.2	20.5	Neutral
OV	Ovarian serous cystadenocarcinoma	300	0.196	0.000654	59.7	24.7	15.7	Loss
PAAD	Pancreatic adenocarcinoma	177	0.104	0.168	46.9	50.3	2.8	Loss
PCPG	Pheochromocytoma and Paraganglioma	162	0.171	0.0293	12.3	82.1	5.6	Neutral
PRAD	Prostate adenocarcinoma	491	0.033	0.472	9.8	89	1.2	Neutral
READ	Rectum adenocarcinoma	164	0.022	0.782	15.2	62.8	22	Neutral
SARC	Sarcoma	255	0.195	0.00177	21.6	52.5	25.9	Neutral
SKCM	Skin Cutaneous Melanoma	367	-0.01	0.849	59.4	34.3	6.3	Loss
STAD	Stomach adenocarcinoma	413	0.064	0.191	15.5	65.6	18.9	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.24	0.00314	14.7	72	13.3	Neutral
THCA	Thyroid carcinoma	497	0.005	0.912	1.4	98.2	0.4	Neutral
THYM	Thymoma	119	0.009	0.926	16.8	83.2	0	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	-0.048	0.263	7.1	79.5	13.4	Neutral

Summary
Symbol	EYA4
Name	EYA transcriptional coactivator and phosphatase 4
Aliases	DFNA10; CMD1J; eyes absent (Drosophila) homolog 4; eyes absent homolog 4 (Drosophila); dJ78N10.1 (eyes absen ......
Location	6q23.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.48	0	17	408	0.376	9.33e-09	Increased
BRCA	Breast invasive carcinoma	-0.149	1.02e-05	83	785	0.01	2.02e-55	NS/NA
CESC	Cervical and endocervical cancers	-0.473	0	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.354	1.29e-10	19	297	0.402	1.34e-60	Increased
ESCA	Esophageal carcinoma	-0.49	0	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.716	0	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.432	0	20	522	0.353	7.24e-16	Increased
KIRC	Kidney renal clear cell carcinoma	-0.419	0	24	319	0.045	3.69e-20	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.189	0.00106	23	275	0.076	1.89e-23	NS/NA
LGG	Brain Lower Grade Glioma	-0.605	0	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.279	8.6e-09	41	373	0.325	2.5e-50	Increased
LUAD	Lung adenocarcinoma	-0.504	0	21	456	0.217	2.46e-48	Increased
LUSC	Lung squamous cell carcinoma	-0.302	2.52e-09	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.817	0.0108	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.395	3.98e-08	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.189	0.00976	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.627	0	35	498	0.462	9.99e-17	Increased
READ	Rectum adenocarcinoma	-0.205	0.04	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.485	0	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.495	0	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.216	2.83e-05	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.403	2.3e-07	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.296	1.09e-12	50	509	0.034	2.94e-11	NS/NA
THYM	Thymoma	-0.652	0	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.527	0	34	431	0.109	3.78e-28	NS/NA

Summary
Symbol	EYA4
Name	EYA transcriptional coactivator and phosphatase 4
Aliases	DFNA10; CMD1J; eyes absent (Drosophila) homolog 4; eyes absent homolog 4 (Drosophila); dJ78N10.1 (eyes absen ......
Location	6q23.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	2	Medium
Appendix	2	Medium
Bone marrow	1	Low
Breast	0	Not detected
Bronchus	2	Medium
Caudate	2	Medium
Cerebellum	2	Medium
Cerebral cortex	1	Low
Cervix, uterine	1	Low
Colon	2	Medium
Duodenum	2	Medium
Endometrium	0	Not detected
Epididymis	1	Low
Esophagus	1	Low
Fallopian tube	2	Medium
Gallbladder	2	Medium
Heart muscle	3	High
Hippocampus	2	Medium
Kidney	2	Medium
Liver	2	Medium
Lung	1	Low
Lymph node	0	Not detected
Nasopharynx	2	Medium
Oral mucosa	0	Not detected
Ovary	0	Not detected
Pancreas	2	Medium
Parathyroid gland	2	Medium
Placenta	1	Low
Prostate	2	Medium
Rectum	2	Medium
Salivary gland	2	Medium
Seminal vesicle	2	Medium
Skeletal muscle	3	High
Skin	2	Medium
Small intestine	2	Medium
Smooth muscle	0	Not detected
Soft tissue	1	Low
Spleen	1	Low
Stomach	2	Medium
Testis	2	Medium
Thyroid gland	2	Medium
Tonsil	1	Low
Urinary bladder	2	Medium
Vagina	2	Medium

Summary
Symbol	EYA4
Name	EYA transcriptional coactivator and phosphatase 4
Aliases	DFNA10; CMD1J; eyes absent (Drosophila) homolog 4; eyes absent homolog 4 (Drosophila); dJ78N10.1 (eyes absen ......
Location	6q23.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.453	NS	24476821
BRCA	Breast invasive carcinoma	521	8.15e-10	Significant	23000897
COAD	Colon adenocarcinoma	149	0.000153	Significant	22810696
GBM	Glioblastoma multiforme	157	0.00238	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	1.15e-10	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.161	NS	26536169
LGG	Brain Lower Grade Glioma	513	4.1e-28	Significant	26824661
LUAD	Lung adenocarcinoma	230	0.324	NS	25079552
LUSC	Lung squamous cell carcinoma	178	0.0259	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	1.77e-09	Significant	21720365
PRAD	Prostate adenocarcinoma	333	0.0115	Significant	26544944
READ	Rectum adenocarcinoma	67	0.041	Significant	22810696
SKCM	Skin Cutaneous Melanoma	315	0.137	NS	26091043
STAD	Stomach adenocarcinoma	277	8.98e-08	Significant	25079317
THCA	Thyroid carcinoma	391	0.842	NS	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	4.8e-12	Significant	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	1.506	0.0482	Shorter
BRCA	Breast invasive carcinoma	1079	0.968	0.893	NS
CESC	Cervical and endocervical cancers	291	1.005	0.987	NS
COAD	Colon adenocarcinoma	439	1.19	0.545	NS
ESCA	Esophageal carcinoma	184	0.994	0.984	NS
GBM	Glioblastoma multiforme	158	1.104	0.697	NS
HNSC	Head and Neck squamous cell carcinoma	518	1.378	0.11	NS
KIRC	Kidney renal clear cell carcinoma	531	0.621	0.0266	Longer
KIRP	Kidney renal papillary cell carcinoma	287	2.757	0.0111	Shorter
LGG	Brain Lower Grade Glioma	511	3.763	2.2e-07	Shorter
LIHC	Liver hepatocellular carcinoma	365	0.976	0.917	NS
LUAD	Lung adenocarcinoma	502	1.294	0.213	NS
LUSC	Lung squamous cell carcinoma	494	1.069	0.726	NS
OV	Ovarian serous cystadenocarcinoma	303	1.692	0.012	Shorter
PAAD	Pancreatic adenocarcinoma	177	1.175	0.59	NS
PCPG	Pheochromocytoma and Paraganglioma	179	507336136.687	0.0664	NS
PRAD	Prostate adenocarcinoma	497	0.501	0.565	NS
READ	Rectum adenocarcinoma	159	1.297	0.627	NS
SARC	Sarcoma	259	2.258	0.00423	Shorter
SKCM	Skin Cutaneous Melanoma	459	1.027	0.893	NS
STAD	Stomach adenocarcinoma	388	1.302	0.245	NS
TGCT	Testicular Germ Cell Tumors	134	574088864.867	0.326	NS
THCA	Thyroid carcinoma	500	1.177	0.842	NS
THYM	Thymoma	119	1.798	0.502	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	4.442	3.95e-06	Shorter

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	0.14	0.00461	Higher
BRCA	Breast invasive carcinoma	1071	-0.04	0.19	NS
CESC	Cervical and endocervical cancers	167	-0.027	0.733	NS
COAD	Colon adenocarcinoma	445	0.079	0.0948	NS
ESCA	Esophageal carcinoma	162	0.172	0.0284	Higher
HNSC	Head and Neck squamous cell carcinoma	448	0.055	0.248	NS
KIRC	Kidney renal clear cell carcinoma	531	-0.117	0.00708	Lower
KIRP	Kidney renal papillary cell carcinoma	260	0.144	0.0202	Higher
LIHC	Liver hepatocellular carcinoma	347	0.046	0.389	NS
LUAD	Lung adenocarcinoma	507	0.079	0.0769	NS
LUSC	Lung squamous cell carcinoma	497	-0.017	0.706	NS
OV	Ovarian serous cystadenocarcinoma	302	-0.077	0.18	NS
PAAD	Pancreatic adenocarcinoma	176	0.04	0.601	NS
READ	Rectum adenocarcinoma	156	0.002	0.984	NS
SKCM	Skin Cutaneous Melanoma	410	0.08	0.107	NS
STAD	Stomach adenocarcinoma	392	0.116	0.0213	Higher
TGCT	Testicular Germ Cell Tumors	81	0.331	0.00257	Higher
THCA	Thyroid carcinoma	499	0.125	0.00533	Higher
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.241	4.6e-08	Higher

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	-0.032	0.6	NS
HNSC	Head and Neck squamous cell carcinoma	498	0.029	0.524	NS
KIRC	Kidney renal clear cell carcinoma	525	-0.219	4.07e-07	Lower
LGG	Brain Lower Grade Glioma	514	0.129	0.00341	Higher
LIHC	Liver hepatocellular carcinoma	366	0.062	0.24	NS
OV	Ovarian serous cystadenocarcinoma	296	-0.085	0.146	NS
PAAD	Pancreatic adenocarcinoma	176	0.06	0.429	NS
STAD	Stomach adenocarcinoma	406	0.106	0.0325	Higher
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.325	1.21e-14	Higher

Summary
Symbol	EYA4
Name	EYA transcriptional coactivator and phosphatase 4
Aliases	DFNA10; CMD1J; eyes absent (Drosophila) homolog 4; eyes absent homolog 4 (Drosophila); dJ78N10.1 (eyes absen ......
Location	6q23.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	EYA4
Name	EYA transcriptional coactivator and phosphatase 4
Aliases	DFNA10; CMD1J; eyes absent (Drosophila) homolog 4; eyes absent homolog 4 (Drosophila); dJ78N10.1 (eyes absen ......
Location	6q23.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for EYA4.

Summary
Symbol	EYA4
Name	EYA transcriptional coactivator and phosphatase 4
Aliases	DFNA10; CMD1J; eyes absent (Drosophila) homolog 4; eyes absent homolog 4 (Drosophila); dJ78N10.1 (eyes absen ......
Location	6q23.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
27231175	Acute Myeloid Leukemia	upstream	AML1-ETO	negative regulation	We demonstrated that AML1-ETO triggered the epigenetic silencing of EYA4 gene by binding at AML1-binding sites and recruiting histone deacetylase 1 and DNA methyltransferases.