Browse FMR1 in pancancer

Summary
SymbolFMR1
Namefragile X mental retardation 1
Aliases FMRP; MGC87458; POF1; premature ovarian failure 1; Protein FMR-1; Fragile X mental retardation protein 1
LocationXq27.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Domain, Function and Classification
> Gene Ontology
> KEGG and Reactome Pathway
> Domain, Function and Classification
 
Domain PF05641 Agenet domain
PF16098 Fragile X-related mental retardation protein C-terminal region 2
PF12235 Fragile X-related 1 protein core C terminal
PF00013 KH domain
Function

Multifunctional polyribosome-associated RNA-binding protein that plays a central role in neuronal development and synaptic plasticity through the regulation of alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of a subset of mRNAs (PubMed:16631377, PubMed:18653529, PubMed:19166269, PubMed:23235829, PubMed:25464849). Plays a role in the alternative splicing of its own mRNA (PubMed:18653529). Plays a role in mRNA nuclear export (By similarity). Together with export factor NXF2, is involved in the regulation of the NXF1 mRNA stability in neurons (By similarity). Stabilizes the scaffolding postsynaptic density protein DLG4/PSD-95 and the myelin basic protein (MBP) mRNAs in hippocampal neurons and glial cells, respectively; this stabilization is further increased in response to metabotropic glutamate receptor (mGluR) stimulation (By similarity). Plays a role in selective delivery of a subset of dendritic mRNAs to synaptic sites in response to mGluR activation in a kinesin-dependent manner (By similarity). Plays a role as a repressor of mRNA translation during the transport of dendritic mRNAs to postnyaptic dendritic spines (PubMed:11532944, PubMed:11157796, PubMed:12594214, PubMed:23235829). Component of the CYFIP1-EIF4E-FMR1 complex which blocks cap-dependent mRNA translation initiation (By similarity). Represses mRNA translation by stalling ribosomal translocation during elongation (By similarity). Reports are contradictory with regards to its ability to mediate translation inhibition of MBP mRNA in oligodendrocytes (PubMed:23891804). Also involved in the recruitment of the RNA helicase MOV10 to a subset of mRNAs and hence regulates microRNA (miRNA)-mediated translational repression by AGO2 (PubMed:14703574, PubMed:17057366, PubMed:25464849). Facilitates the assembly of miRNAs on specific target mRNAs (PubMed:17057366). Plays also a role as an activator of mRNA translation of a subset of dendritic mRNAs at synapses (PubMed:19097999, PubMed:19166269). In response to mGluR stimulation, FMR1-target mRNAs are rapidly derepressed, allowing for local translation at synapses (By similarity). Binds to a large subset of dendritic mRNAs that encode a myriad of proteins involved in pre- and postsynaptic functions (PubMed:7692601, PubMed:11719189, PubMed:11157796, PubMed:12594214, PubMed:17417632, PubMed:23235829, PubMed:24448548). Binds to 5'-ACU[GU]-3' and/or 5'-[AU]GGA-3' RNA consensus sequences within mRNA targets, mainly at coding sequence (CDS) and 3'-untranslated region (UTR) and less frequently at 5'-UTR (PubMed:23235829). Binds to intramolecular G-quadruplex structures in the 5'- or 3'-UTRs of mRNA targets (PubMed:11719189, PubMed:18579868, PubMed:25464849, PubMed:25692235). Binds to G-quadruplex structures in the 3'-UTR of its own mRNA (PubMed:7692601, PubMed:11532944, PubMed:12594214, PubMed:15282548, PubMed:18653529). Binds also to RNA ligands harboring a kissing complex (kc) structure; this binding may mediate the association of FMR1 with polyribosomes (PubMed:15805463). Binds mRNAs containing U-rich target sequences (PubMed:12927206). Binds to a triple stem-loop RNA structure, called Sod1 stem loop interacting with FMRP (SoSLIP), in the 5'-UTR region of superoxide dismutase SOD1 mRNA (PubMed:19166269). Binds to the dendritic, small non-coding brain cytoplasmic RNA 1 (BC1); which may increase the association of the CYFIP1-EIF4E-FMR1 complex to FMR1 target mRNAs at synapses (By similarity). Associates with export factor NXF1 mRNA-containing ribonucleoprotein particles (mRNPs) in a NXF2-dependent manner (By similarity). Binds to a subset of miRNAs in the brain (PubMed:14703574, PubMed:17057366). May associate with nascent transcripts in a nuclear protein NXF1-dependent manner (PubMed:18936162). In vitro, binds to RNA homopolymer; preferentially on poly(G) and to a lesser extent on poly(U), but not on poly(A) or poly(C) (PubMed:7688265, PubMed:7781595, PubMed:12950170, PubMed:15381419, PubMed:8156595). Moreover, plays a role in the modulation of the sodium-activated potassium channel KCNT1 gating activity (PubMed:20512134). Negatively regulates the voltage-dependent calcium channel current density in soma and presynaptic terminals of dorsal root ganglion (DRG) neurons, and hence regulates synaptic vesicle exocytosis (By similarity). Modulates the voltage-dependent calcium channel CACNA1B expression at the plasma membrane by targeting the channels for proteosomal degradation (By similarity). Plays a role in regulation of MAP1B-dependent microtubule dynamics during neuronal development (By similarity). Recently, has been shown to play a translation-independent role in the modulation of presynaptic action potential (AP) duration and neurotransmitter release via large-conductance calcium-activated potassium (BK) channels in hippocampal and cortical excitatory neurons (PubMed:25561520). Finally, FMR1 may be involved in the control of DNA damage response (DDR) mechanisms through the regulation of ATR-dependent signaling pathways such as histone H2AFX/H2A.x and BRCA1 phosphorylations (PubMed:24813610). ; FUNCTION: Isoform 10: binds to RNA homopolymer; preferentially on poly(G) and to a lesser extent on poly(U), but not on poly(A) or poly(C) (PubMed:24204304). May bind to RNA in Cajal bodies (PubMed:24204304). ; FUNCTION: Isoform 6: binds to RNA homopolymer; preferentially on poly(G) and to a lesser extent on poly(U), but not on poly(A) or poly(C) (PubMed:24204304). May bind to RNA in Cajal bodies (PubMed:24204304). ; FUNCTION: (Microbial infection) Acts as a positive regulator of influenza A virus (IAV) replication. Required for the assembly and nuclear export of the viral ribonucleoprotein (vRNP) components.

Classification
Class Modification Substrate Product PubMed
# # # # #
> Gene Ontology
 
Biological Process GO:0000375 RNA splicing, via transesterification reactions
GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
GO:0000380 alternative mRNA splicing, via spliceosome
GO:0000381 regulation of alternative mRNA splicing, via spliceosome
GO:0000398 mRNA splicing, via spliceosome
GO:0001505 regulation of neurotransmitter levels
GO:0001508 action potential
GO:0002090 regulation of receptor internalization
GO:0002092 positive regulation of receptor internalization
GO:0002181 cytoplasmic translation
GO:0006397 mRNA processing
GO:0006403 RNA localization
GO:0006413 translational initiation
GO:0006417 regulation of translation
GO:0006446 regulation of translational initiation
GO:0006816 calcium ion transport
GO:0006836 neurotransmitter transport
GO:0006887 exocytosis
GO:0006898 receptor-mediated endocytosis
GO:0007215 glutamate receptor signaling pathway
GO:0007269 neurotransmitter secretion
GO:0008380 RNA splicing
GO:0009314 response to radiation
GO:0009411 response to UV
GO:0009416 response to light stimulus
GO:0009615 response to virus
GO:0009894 regulation of catabolic process
GO:0009896 positive regulation of catabolic process
GO:0010035 response to inorganic substance
GO:0010498 proteasomal protein catabolic process
GO:0010608 posttranscriptional regulation of gene expression
GO:0010720 positive regulation of cell development
GO:0010959 regulation of metal ion transport
GO:0010975 regulation of neuron projection development
GO:0010976 positive regulation of neuron projection development
GO:0015931 nucleobase-containing compound transport
GO:0016079 synaptic vesicle exocytosis
GO:0016358 dendrite development
GO:0016441 posttranscriptional gene silencing
GO:0016458 gene silencing
GO:0016570 histone modification
GO:0016572 histone phosphorylation
GO:0017148 negative regulation of translation
GO:0017156 calcium ion regulated exocytosis
GO:0017157 regulation of exocytosis
GO:0017158 regulation of calcium ion-dependent exocytosis
GO:0019058 viral life cycle
GO:0019079 viral genome replication
GO:0019226 transmission of nerve impulse
GO:0019228 neuronal action potential
GO:0022898 regulation of transmembrane transporter activity
GO:0023061 signal release
GO:0030031 cell projection assembly
GO:0030100 regulation of endocytosis
GO:0031047 gene silencing by RNA
GO:0031056 regulation of histone modification
GO:0031058 positive regulation of histone modification
GO:0031329 regulation of cellular catabolic process
GO:0031331 positive regulation of cellular catabolic process
GO:0031346 positive regulation of cell projection organization
GO:0031623 receptor internalization
GO:0031644 regulation of neurological system process
GO:0032386 regulation of intracellular transport
GO:0032388 positive regulation of intracellular transport
GO:0032409 regulation of transporter activity
GO:0032410 negative regulation of transporter activity
GO:0032412 regulation of ion transmembrane transporter activity
GO:0032413 negative regulation of ion transmembrane transporter activity
GO:0033127 regulation of histone phosphorylation
GO:0033129 positive regulation of histone phosphorylation
GO:0034248 regulation of cellular amide metabolic process
GO:0034249 negative regulation of cellular amide metabolic process
GO:0034250 positive regulation of cellular amide metabolic process
GO:0034644 cellular response to UV
GO:0034762 regulation of transmembrane transport
GO:0034763 negative regulation of transmembrane transport
GO:0034765 regulation of ion transmembrane transport
GO:0034766 negative regulation of ion transmembrane transport
GO:0035194 posttranscriptional gene silencing by RNA
GO:0035195 gene silencing by miRNA
GO:0035637 multicellular organismal signaling
GO:0035821 modification of morphology or physiology of other organism
GO:0039694 viral RNA genome replication
GO:0039703 RNA replication
GO:0040029 regulation of gene expression, epigenetic
GO:0042176 regulation of protein catabolic process
GO:0042391 regulation of membrane potential
GO:0043112 receptor metabolic process
GO:0043271 negative regulation of ion transport
GO:0043484 regulation of RNA splicing
GO:0043487 regulation of RNA stability
GO:0043488 regulation of mRNA stability
GO:0043900 regulation of multi-organism process
GO:0043902 positive regulation of multi-organism process
GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism
GO:0044033 multi-organism metabolic process
GO:0044057 regulation of system process
GO:0044089 positive regulation of cellular component biogenesis
GO:0044766 multi-organism transport
GO:0044788 modulation by host of viral process
GO:0044827 modulation by host of viral genome replication
GO:0044830 modulation by host of viral RNA genome replication
GO:0045055 regulated exocytosis
GO:0045069 regulation of viral genome replication
GO:0045666 positive regulation of neuron differentiation
GO:0045727 positive regulation of translation
GO:0045732 positive regulation of protein catabolic process
GO:0045807 positive regulation of endocytosis
GO:0045862 positive regulation of proteolysis
GO:0045920 negative regulation of exocytosis
GO:0045947 negative regulation of translational initiation
GO:0045955 negative regulation of calcium ion-dependent exocytosis
GO:0046794 transport of virus
GO:0046847 filopodium assembly
GO:0046928 regulation of neurotransmitter secretion
GO:0046929 negative regulation of neurotransmitter secretion
GO:0048024 regulation of mRNA splicing, via spliceosome
GO:0048167 regulation of synaptic plasticity
GO:0048259 regulation of receptor-mediated endocytosis
GO:0048260 positive regulation of receptor-mediated endocytosis
GO:0048489 synaptic vesicle transport
GO:0048524 positive regulation of viral process
GO:0050657 nucleic acid transport
GO:0050658 RNA transport
GO:0050684 regulation of mRNA processing
GO:0050769 positive regulation of neurogenesis
GO:0050773 regulation of dendrite development
GO:0050792 regulation of viral process
GO:0050804 modulation of synaptic transmission
GO:0050805 negative regulation of synaptic transmission
GO:0050806 positive regulation of synaptic transmission
GO:0051028 mRNA transport
GO:0051048 negative regulation of secretion
GO:0051051 negative regulation of transport
GO:0051098 regulation of binding
GO:0051099 positive regulation of binding
GO:0051236 establishment of RNA localization
GO:0051489 regulation of filopodium assembly
GO:0051491 positive regulation of filopodium assembly
GO:0051588 regulation of neurotransmitter transport
GO:0051589 negative regulation of neurotransmitter transport
GO:0051640 organelle localization
GO:0051648 vesicle localization
GO:0051650 establishment of vesicle localization
GO:0051656 establishment of organelle localization
GO:0051702 interaction with symbiont
GO:0051817 modification of morphology or physiology of other organism involved in symbiotic interaction
GO:0051851 modification by host of symbiont morphology or physiology
GO:0051924 regulation of calcium ion transport
GO:0051926 negative regulation of calcium ion transport
GO:0051962 positive regulation of nervous system development
GO:0051969 regulation of transmission of nerve impulse
GO:0060147 regulation of posttranscriptional gene silencing
GO:0060148 positive regulation of posttranscriptional gene silencing
GO:0060292 long term synaptic depression
GO:0060491 regulation of cell projection assembly
GO:0060627 regulation of vesicle-mediated transport
GO:0060964 regulation of gene silencing by miRNA
GO:0060966 regulation of gene silencing by RNA
GO:0060968 regulation of gene silencing
GO:0060996 dendritic spine development
GO:0060998 regulation of dendritic spine development
GO:0060999 positive regulation of dendritic spine development
GO:0061136 regulation of proteasomal protein catabolic process
GO:0070588 calcium ion transmembrane transport
GO:0070838 divalent metal ion transport
GO:0071214 cellular response to abiotic stimulus
GO:0071241 cellular response to inorganic substance
GO:0071478 cellular response to radiation
GO:0071482 cellular response to light stimulus
GO:0072511 divalent inorganic cation transport
GO:0072710 response to hydroxyurea
GO:0072711 cellular response to hydroxyurea
GO:0075733 intracellular transport of virus
GO:0097479 synaptic vesicle localization
GO:0097480 establishment of synaptic vesicle localization
GO:0098586 cellular response to virus
GO:0098900 regulation of action potential
GO:0098908 regulation of neuronal action potential
GO:0099003 vesicle-mediated transport in synapse
GO:0099504 synaptic vesicle cycle
GO:0099531 presynaptic process involved in chemical synaptic transmission
GO:0099643 signal release from synapse
GO:1900006 positive regulation of dendrite development
GO:1900452 regulation of long term synaptic depression
GO:1900453 negative regulation of long term synaptic depression
GO:1901019 regulation of calcium ion transmembrane transporter activity
GO:1901020 negative regulation of calcium ion transmembrane transporter activity
GO:1901252 regulation of intracellular transport of viral material
GO:1901254 positive regulation of intracellular transport of viral material
GO:1901385 regulation of voltage-gated calcium channel activity
GO:1901386 negative regulation of voltage-gated calcium channel activity
GO:1901800 positive regulation of proteasomal protein catabolic process
GO:1902275 regulation of chromatin organization
GO:1902415 regulation of mRNA binding
GO:1902416 positive regulation of mRNA binding
GO:1902579 multi-organism localization
GO:1902581 multi-organism cellular localization
GO:1902583 multi-organism intracellular transport
GO:1902803 regulation of synaptic vesicle transport
GO:1902804 negative regulation of synaptic vesicle transport
GO:1903050 regulation of proteolysis involved in cellular protein catabolic process
GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process
GO:1903169 regulation of calcium ion transmembrane transport
GO:1903170 negative regulation of calcium ion transmembrane transport
GO:1903305 regulation of regulated secretory pathway
GO:1903306 negative regulation of regulated secretory pathway
GO:1903311 regulation of mRNA metabolic process
GO:1903362 regulation of cellular protein catabolic process
GO:1903364 positive regulation of cellular protein catabolic process
GO:1903531 negative regulation of secretion by cell
GO:1903900 regulation of viral life cycle
GO:1903902 positive regulation of viral life cycle
GO:1904062 regulation of cation transmembrane transport
GO:1904063 negative regulation of cation transmembrane transport
GO:1905214 regulation of RNA binding
GO:1905216 positive regulation of RNA binding
GO:1905269 positive regulation of chromatin organization
GO:2000300 regulation of synaptic vesicle exocytosis
GO:2000301 negative regulation of synaptic vesicle exocytosis
GO:2000637 positive regulation of gene silencing by miRNA
GO:2000765 regulation of cytoplasmic translation
GO:2000766 negative regulation of cytoplasmic translation
GO:2001020 regulation of response to DNA damage stimulus
GO:2001022 positive regulation of response to DNA damage stimulus
GO:2001257 regulation of cation channel activity
GO:2001258 negative regulation of cation channel activity
Molecular Function GO:0002151 G-quadruplex RNA binding
GO:0003682 chromatin binding
GO:0003725 double-stranded RNA binding
GO:0003727 single-stranded RNA binding
GO:0003729 mRNA binding
GO:0003730 mRNA 3'-UTR binding
GO:0008017 microtubule binding
GO:0008187 poly-pyrimidine tract binding
GO:0008266 poly(U) RNA binding
GO:0015631 tubulin binding
GO:0030371 translation repressor activity
GO:0031369 translation initiation factor binding
GO:0033592 RNA strand annealing activity
GO:0034046 poly(G) binding
GO:0035064 methylated histone binding
GO:0035197 siRNA binding
GO:0035198 miRNA binding
GO:0035613 RNA stem-loop binding
GO:0042393 histone binding
GO:0043021 ribonucleoprotein complex binding
GO:0043022 ribosome binding
GO:0044325 ion channel binding
GO:0045182 translation regulator activity
GO:0045502 dynein binding
GO:0046982 protein heterodimerization activity
GO:0048027 mRNA 5'-UTR binding
GO:0070717 poly-purine tract binding
GO:0097617 annealing activity
GO:1990825 sequence-specific mRNA binding
Cellular Component GO:0000775 chromosome, centromeric region
GO:0005840 ribosome
GO:0005844 polysome
GO:0005845 mRNA cap binding complex
GO:0010369 chromocenter
GO:0014069 postsynaptic density
GO:0015030 Cajal body
GO:0016604 nuclear body
GO:0018995 host
GO:0019034 viral replication complex
GO:0019897 extrinsic component of plasma membrane
GO:0019898 extrinsic component of membrane
GO:0030175 filopodium
GO:0030424 axon
GO:0030425 dendrite
GO:0030426 growth cone
GO:0030427 site of polarized growth
GO:0032433 filopodium tip
GO:0032797 SMN complex
GO:0032838 cell projection cytoplasm
GO:0033267 axon part
GO:0033643 host cell part
GO:0033646 host intracellular part
GO:0033647 host intracellular organelle
GO:0033648 host intracellular membrane-bounded organelle
GO:0034518 RNA cap binding complex
GO:0035770 ribonucleoprotein granule
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0042025 host cell nucleus
GO:0042734 presynaptic membrane
GO:0042788 polysomal ribosome
GO:0043025 neuronal cell body
GO:0043197 dendritic spine
GO:0043204 perikaryon
GO:0043656 intracellular region of host
GO:0043657 host cell
GO:0043679 axon terminus
GO:0044094 host cell nuclear part
GO:0044215 other organism
GO:0044216 other organism cell
GO:0044217 other organism part
GO:0044297 cell body
GO:0044306 neuron projection terminus
GO:0044309 neuron spine
GO:0045211 postsynaptic membrane
GO:0060076 excitatory synapse
GO:0071598 neuronal ribonucleoprotein granule
GO:0097060 synaptic membrane
GO:0097386 glial cell projection
GO:0098687 chromosomal region
GO:0098793 presynapse
GO:0098794 postsynapse
GO:0098858 actin-based cell projection
GO:0099568 cytoplasmic region
GO:0099572 postsynaptic specialization
GO:1902737 dendritic filopodium
GO:1990812 growth cone filopodium
> KEGG and Reactome Pathway
 
KEGG hsa03013 RNA transport
Reactome -
Summary
SymbolFMR1
Namefragile X mental retardation 1
Aliases FMRP; MGC87458; POF1; premature ovarian failure 1; Protein FMR-1; Fragile X mental retardation protein 1
LocationXq27.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Mutation landscape in primary tumor tissue from TCGA
> Mutation landscape in cancer cell line from CCLE
> All mutations from COSMIC database V81
> Variations from text mining
> The Cancer Genome Atlas (TCGA)
 
> Cancer Cell Line Encyclopedia (CCLE)
 
There is no record.
> Catalogue of Somatic Mutations in Cancer (COSMIC)
 
COSMIC ID CDS change AA change Mutation Type Anatomical Site
COSM1252631c.1212G>Tp.V404VSubstitution - coding silentOesophagus
COSM4107283c.1821G>Ap.T607TSubstitution - coding silentStomach
COSM4685174c.1762A>Tp.R588WSubstitution - MissenseLarge_intestine
COSM1116469c.1265A>Cp.N422TSubstitution - MissenseEndometrium
COSM4156642c.357A>Cp.K119NSubstitution - MissenseUpper_aerodigestive_tract
COSM287889c.1452C>Tp.R484RSubstitution - coding silentLarge_intestine
COSM1625591c.843T>Cp.F281FSubstitution - coding silentLiver
COSM1756431c.988G>Cp.E330QSubstitution - MissenseUrinary_tract
COSM4107267c.225G>Ap.E75ESubstitution - coding silentStomach
COSM260970c.1580G>Ap.R527HSubstitution - MissenseBreast
COSM1331191c.1817G>Ap.R606HSubstitution - MissenseLarge_intestine
COSM4156642c.357A>Cp.K119NSubstitution - MissenseUpper_aerodigestive_tract
COSM4107275c.586T>Gp.L196VSubstitution - MissenseStomach
COSM4685172c.1055delAp.K354fs*3Deletion - FrameshiftLarge_intestine
COSM1176797c.610G>Ap.E204KSubstitution - MissenseEndometrium
COSM5064451c.451delAp.K152fs*8Deletion - FrameshiftStomach
COSM1756431c.988G>Cp.E330QSubstitution - MissenseUrinary_tract
COSM4002269c.198+9T>Cp.?UnknownHaematopoietic_and_lymphoid_tissue
COSM3233466c.1226G>Ap.S409NSubstitution - MissenseBone
COSM3694384c.990+2T>Cp.?UnknownLarge_intestine
COSM756014c.1000C>Tp.P334SSubstitution - MissenseLung
COSM69351c.270+1G>Tp.?UnknownOvary
COSM456905c.1525G>Ap.E509KSubstitution - MissenseBreast
COSM3964838c.51+8G>Ap.?UnknownLung
COSM4685171c.966T>Cp.N322NSubstitution - coding silentLarge_intestine
COSM5989617c.309delCp.Y103fs*1Deletion - FrameshiftHaematopoietic_and_lymphoid_tissue
COSM266551c.1292G>Ap.R431HSubstitution - MissenseLarge_intestine
COSM4156642c.357A>Cp.K119NSubstitution - MissenseUpper_aerodigestive_tract
COSM5617522c.909G>Cp.L303LSubstitution - coding silentLung
COSM1116470c.1324C>Tp.R442*Substitution - NonsenseEndometrium
COSM5004210c.1861G>Ap.V621MSubstitution - MissenseHaematopoietic_and_lymphoid_tissue
COSM3379546c.569G>Ap.R190QSubstitution - MissensePancreas
COSM3558879c.1197A>Gp.V399VSubstitution - coding silentSkin
COSM1116480c.1883T>Cp.V628ASubstitution - MissenseEndometrium
COSM4685169c.602G>Tp.R201ISubstitution - MissenseLarge_intestine
COSM5781383c.434C>Ap.A145ESubstitution - MissenseBreast
COSM5015767c.421T>Cp.C141RSubstitution - MissenseKidney
COSM4823170c.357A>Gp.K119KSubstitution - coding silentCervix
COSM5414277c.1188+5G>Ap.?UnknownHaematopoietic_and_lymphoid_tissue
COSM4107277c.615T>Gp.A205ASubstitution - coding silentStomach
COSM5412154c.1265A>Gp.N422SSubstitution - MissenseSkin
COSM266551c.1292G>Ap.R431HSubstitution - MissenseEndometrium
COSM1625592c.1603G>Tp.G535*Substitution - NonsenseLiver
COSM1580267c.1016C>Tp.P339LSubstitution - MissenseCentral_nervous_system
COSM4156642c.357A>Cp.K119NSubstitution - MissenseUpper_aerodigestive_tract
COSM1625592c.1603G>Tp.G535*Substitution - NonsenseLiver
COSM3379546c.569G>Ap.R190QSubstitution - MissensePancreas
COSM4854321c.694C>Gp.L232VSubstitution - MissenseCervix
COSM3558878c.1160C>Tp.S387FSubstitution - MissenseSkin
COSM3913517c.1499C>Tp.S500FSubstitution - MissenseSkin
COSM5571347c.1128G>Ap.V376VSubstitution - coding silentProstate
COSM373883c.224A>Tp.E75VSubstitution - MissenseLung
COSM1116476c.1673G>Ap.R558QSubstitution - MissenseEndometrium
COSM70802c.1325G>Ap.R442QSubstitution - MissenseOvary
COSM4887351c.1033G>Ap.V345ISubstitution - MissenseUpper_aerodigestive_tract
COSM5662984c.1419T>Cp.S473SSubstitution - coding silentSoft_tissue
COSM4643394c.700A>Gp.I234VSubstitution - MissenseLarge_intestine
COSM1116464c.836T>Cp.L279PSubstitution - MissenseEndometrium
COSM4952773c.1822G>Tp.G608CSubstitution - MissenseLiver
COSM1726869c.704G>Tp.G235VSubstitution - MissenseLiver
COSM4918031c.977T>Cp.V326ASubstitution - MissenseLiver
COSM3558880c.1372G>Ap.E458KSubstitution - MissenseSkin
COSM1116463c.831C>Ap.S277RSubstitution - MissenseEndometrium
COSM3233485c.1818C>Tp.R606RSubstitution - coding silentLarge_intestine
COSM1116461c.749T>Cp.V250ASubstitution - MissenseEndometrium
COSM5774720c.1019C>Tp.S340FSubstitution - MissenseBreast
COSM4685173c.1412G>Ap.R471QSubstitution - MissenseLarge_intestine
COSM4799543c.1256A>Gp.Y419CSubstitution - MissenseLiver
COSM3372112c.1541C>Tp.S514LSubstitution - MissenseThyroid
COSM1116462c.781A>Gp.T261ASubstitution - MissenseEndometrium
COSM260970c.1580G>Ap.R527HSubstitution - MissenseLarge_intestine
COSM260968c.413G>Ap.R138QSubstitution - MissenseLarge_intestine
COSM3964840c.853G>Tp.V285LSubstitution - MissenseLung
COSM5443924c.1724A>Tp.D575VSubstitution - MissenseOesophagus
COSM4156646c.1211T>Gp.V404GSubstitution - MissenseThyroid
COSM161113c.578G>Ap.R193HSubstitution - MissenseBreast
COSM756012c.1449A>Gp.R483RSubstitution - coding silentLung
COSM5080820c.420-9A>Cp.?UnknownLarge_intestine
COSM5414277c.1188+5G>Ap.?UnknownSkin
COSM3390467c.513+3G>Ap.?UnknownPancreas
COSM5986494c.989A>Tp.E330VSubstitution - MissenseHaematopoietic_and_lymphoid_tissue
COSM4156647c.1215A>Gp.G405GSubstitution - coding silentThyroid
COSM3843791c.283G>Ap.E95KSubstitution - MissenseBreast
COSM4107269c.294A>Gp.A98ASubstitution - coding silentStomach
COSM4156642c.357A>Cp.K119NSubstitution - MissenseUpper_aerodigestive_tract
COSM3558877c.1011C>Tp.S337SSubstitution - coding silentSkin
COSM5064453c.568C>Tp.R190WSubstitution - MissenseStomach
COSM1466201c.1374A>Gp.E458ESubstitution - coding silentLarge_intestine
COSM85250c.1848G>Tp.E616DSubstitution - MissensePancreas
COSM205746c.1816C>Tp.R606CSubstitution - MissenseBreast
COSM3780367c.1886A>Tp.N629ISubstitution - MissensePancreas
COSM3233474c.1378A>Gp.S460GSubstitution - MissenseUpper_aerodigestive_tract
COSM4799543c.1256A>Gp.Y419CSubstitution - MissenseLiver
COSM5682641c.1336G>Tp.A446SSubstitution - MissenseSoft_tissue
COSM5666239c.203A>Gp.Y68CSubstitution - MissenseSoft_tissue
COSM4107273c.409T>Cp.L137LSubstitution - coding silentStomach
COSM205746c.1816C>Tp.R606CSubstitution - MissenseBreast
COSM1116468c.1084A>Gp.S362GSubstitution - MissenseEndometrium
COSM260971c.1590C>Tp.D530DSubstitution - coding silentBreast
COSM5677559c.127C>Gp.P43ASubstitution - MissenseSoft_tissue
COSM3363851c.457G>Cp.A153PSubstitution - MissenseKidney
COSM1636417c.1471+1G>Ap.?UnknownLiver
COSM4817159c.533C>Gp.S178*Substitution - NonsenseCervix
COSM161113c.578G>Ap.R193HSubstitution - MissenseBreast
COSM4685175c.1785A>Gp.L595LSubstitution - coding silentLarge_intestine
COSM456905c.1525G>Ap.E509KSubstitution - MissenseCervix
COSM3233471c.1329G>Ap.Q443QSubstitution - coding silentUpper_aerodigestive_tract
COSM1569654c.595A>Gp.I199VSubstitution - MissenseLarge_intestine
COSM4156644c.698C>Ap.A233DSubstitution - MissenseThyroid
COSM260971c.1590C>Tp.D530DSubstitution - coding silentLarge_intestine
COSM367831c.763C>Ap.L255ISubstitution - MissenseLung
COSM3973350c.377T>Cp.F126SSubstitution - MissenseCentral_nervous_system
COSM3233486c.1897T>Cp.*633QNonstop extensionPancreas
COSM3233458c.1054_1055insAp.H355fs*15Insertion - FrameshiftLarge_intestine
COSM3759386c.414G>Ap.R138RSubstitution - coding silentLarge_intestine
COSM1116472c.1444G>Ap.G482SSubstitution - MissenseEndometrium
COSM3363853c.1852C>Ap.P618TSubstitution - MissenseKidney
COSM756011c.1862T>Ap.V621ESubstitution - MissenseLung
COSM1116479c.1831C>Tp.R611CSubstitution - MissenseEndometrium
COSM1625591c.843T>Cp.F281FSubstitution - coding silentLiver
COSM1466198c.797G>Ap.G266ESubstitution - MissenseLarge_intestine
COSM4952773c.1822G>Tp.G608CSubstitution - MissenseLiver
COSM4770472c.901G>Tp.G301*Substitution - NonsenseAdrenal_gland
COSM1490574c.175A>Cp.I59LSubstitution - MissenseBreast
COSM756016c.539G>Tp.R180LSubstitution - MissenseLung
COSM3233483c.1716A>Tp.R572SSubstitution - MissenseLarge_intestine
COSM1466196c.362C>Tp.A121VSubstitution - MissenseLarge_intestine
COSM611328c.198+5G>Tp.?UnknownAdrenal_gland
COSM1756430c.581C>Tp.T194ISubstitution - MissenseUrinary_tract
COSM4156642c.357A>Cp.K119NSubstitution - MissenseUpper_aerodigestive_tract
COSM456904c.859C>Gp.Q287ESubstitution - MissenseBreast
COSM1331191c.1817G>Ap.R606HSubstitution - MissenseOvary
COSM1490575c.1690C>Gp.R564GSubstitution - MissenseBreast
COSM4156642c.357A>Cp.K119NSubstitution - MissenseThyroid
COSM5663547c.1050A>Gp.P350PSubstitution - coding silentSoft_tissue
COSM1116470c.1324C>Tp.R442*Substitution - NonsenseEndometrium
COSM3747343c.198+4A>Gp.?UnknownLiver
COSM1116473c.1585G>Tp.G529*Substitution - NonsenseEndometrium
COSM3233433c.112C>Gp.P38ASubstitution - MissenseStomach
COSM4156642c.357A>Cp.K119NSubstitution - MissenseUpper_aerodigestive_tract
COSM4963349c.1684C>Tp.R562CSubstitution - MissensePancreas
COSM4107282c.1685G>Ap.R562HSubstitution - MissenseLarge_intestine
COSM488058c.801G>Tp.E267DSubstitution - MissenseKidney
COSM311247c.74A>Tp.E25VSubstitution - MissenseLung
COSM260971c.1590C>Tp.D530DSubstitution - coding silentLarge_intestine
COSM1715720c.358C>Tp.P120SSubstitution - MissenseSkin
COSM4554164c.613G>Ap.A205TSubstitution - MissenseSkin
COSM1116465c.838G>Ap.E280KSubstitution - MissenseEndometrium
COSM1116479c.1831C>Tp.R611CSubstitution - MissenseLarge_intestine
COSM4156642c.357A>Cp.K119NSubstitution - MissenseUpper_aerodigestive_tract
COSM3379546c.569G>Ap.R190QSubstitution - MissensePancreas
COSM5695430c.1109G>Tp.S370ISubstitution - MissenseSoft_tissue
COSM1116460c.692G>Ap.G231DSubstitution - MissenseEndometrium
COSM4156642c.357A>Cp.K119NSubstitution - MissenseUpper_aerodigestive_tract
COSM3939836c.549G>Tp.M183ISubstitution - MissenseOesophagus
COSM1116467c.963A>Cp.E321DSubstitution - MissenseEndometrium
COSM4985365c.433G>Tp.A145SSubstitution - MissenseSoft_tissue
COSM161114c.1171G>Ap.E391KSubstitution - MissenseBreast
COSM311247c.74A>Tp.E25VSubstitution - MissenseSoft_tissue
COSM5069339c.1551A>Gp.P517PSubstitution - coding silentLarge_intestine
COSM4156648c.1233T>Ap.A411ASubstitution - coding silentThyroid
COSM5625709c.1782A>Gp.T594TSubstitution - coding silentOesophagus
COSM123202c.387C>Gp.I129MSubstitution - MissenseUpper_aerodigestive_tract
COSM3233474c.1378A>Gp.S460GSubstitution - MissenseUpper_aerodigestive_tract
COSM4107271c.300T>Cp.D100DSubstitution - coding silentStomach
COSM4825539c.1666C>Tp.H556YSubstitution - MissenseCervix
COSM756017c.201G>Tp.V67VSubstitution - coding silentLung
COSM1116471c.1424C>Tp.P475LSubstitution - MissenseEndometrium
COSM5455843c.779G>Tp.C260FSubstitution - MissenseLarge_intestine
COSM287889c.1452C>Tp.R484RSubstitution - coding silentBreast
COSM3390469c.1597C>Tp.R533WSubstitution - MissensePancreas
COSM1116477c.1731C>Tp.S577SSubstitution - coding silentEndometrium
COSM1682943c.590C>Ap.S197YSubstitution - MissenseLarge_intestine
COSM287889c.1452C>Tp.R484RSubstitution - coding silentLarge_intestine
COSM1625590c.616A>Gp.S206GSubstitution - MissenseLiver
COSM4156642c.357A>Cp.K119NSubstitution - MissenseUpper_aerodigestive_tract
COSM5442012c.132T>Ap.F44LSubstitution - MissenseOesophagus
COSM260969c.991G>Ap.E331KSubstitution - MissenseLarge_intestine
COSM4107282c.1685G>Ap.R562HSubstitution - MissenseStomach
COSM4156642c.357A>Cp.K119NSubstitution - MissenseUpper_aerodigestive_tract
COSM266551c.1292G>Ap.R431HSubstitution - MissenseLarge_intestine
COSM1116459c.338G>Ap.R113KSubstitution - MissenseEndometrium
COSM4685173c.1412G>Ap.R471QSubstitution - MissenseHaematopoietic_and_lymphoid_tissue
COSM1116470c.1324C>Tp.R442*Substitution - NonsenseCentral_nervous_system
COSM4107281c.1558G>Ap.E520KSubstitution - MissenseStomach
COSM1116475c.1613G>Ap.G538ESubstitution - MissenseEndometrium
COSM85250c.1848G>Tp.E616DSubstitution - MissensePancreas
COSM4107280c.1314T>Cp.D438DSubstitution - coding silentStomach
COSM756013c.1361G>Cp.R454PSubstitution - MissenseLung
COSM1756430c.581C>Tp.T194ISubstitution - MissenseUrinary_tract
COSM1682943c.590C>Ap.S197YSubstitution - MissenseLarge_intestine
COSM4156642c.357A>Cp.K119NSubstitution - MissenseUpper_aerodigestive_tract
COSM5064453c.568C>Tp.R190WSubstitution - MissenseSkin
COSM1116478c.1820C>Tp.T607MSubstitution - MissenseEndometrium
COSM4156642c.357A>Cp.K119NSubstitution - MissenseUpper_aerodigestive_tract
COSM4107282c.1685G>Ap.R562HSubstitution - MissenseStomach
COSM4107279c.1104T>Cp.P368PSubstitution - coding silentStomach
COSM1252632c.1447A>Gp.R483GSubstitution - MissenseOesophagus
COSM1315264c.876A>Gp.L292LSubstitution - coding silentUrinary_tract
COSM4963349c.1684C>Tp.R562CSubstitution - MissensePancreas
COSM1116466c.955G>Ap.E319KSubstitution - MissenseEndometrium
COSM1625590c.616A>Gp.S206GSubstitution - MissenseLiver
COSM1116474c.1594C>Tp.R532WSubstitution - MissenseEndometrium
> Text Mining based Variations
 
There is no record for FMR1.
Summary
SymbolFMR1
Namefragile X mental retardation 1
Aliases FMRP; MGC87458; POF1; premature ovarian failure 1; Protein FMR-1; Fragile X mental retardation protein 1
LocationXq27.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Post-translational modification (PTM)
> Post-translational modification (PTM)
 
 Filter By:
Uniprot ID Position Amino Acid Description Upstream Enzyme Affected By Mutation Amino Acid Sequence Variant
Q06787337SPhosphoserine-NoNone detected
Q06787370SPhosphoserine-NoNone detected
Q06787463TPhosphothreonine-NoNone detected
Q06787471ROmega-N-methylarginine-NoNone detected
Q06787500SPhosphoserine-Yesp.S500F (cancer: SKCM)
Q06787544ROmega-N-methylarginine-NoNone detected
Q06787620SPhosphoserine-NoNone detected
Summary
SymbolFMR1
Namefragile X mental retardation 1
Aliases FMRP; MGC87458; POF1; premature ovarian failure 1; Protein FMR-1; Fragile X mental retardation protein 1
LocationXq27.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Expression analysis in primary tumor tissue from TCGA
> Expression level in cancer cell line from CCLE
> Expression level in human normal tissue from HPA
> Text mining based expression change
> The Cancer Genome Atlas (TCGA)
 


  Differential expression analysis for cancers with more than 10 normal samples
Cancer Full Name # N # T Median (N) Median (T) LogFC Adj. P Status
BLCABladder urothelial carcinoma194085.5955.7910.1930.222NS
BRCABreast invasive carcinoma11211005.6965.8360.2185.37e-05NS
CESCCervical and endocervical cancers33066.0326.163NANANA
COADColon adenocarcinoma414595.4785.7360.2120.072NS
ESCAEsophageal carcinoma111855.5335.9950.4150.0371NS
GBMGlioblastoma multiforme51666.325.774NANANA
HNSCHead and Neck squamous cell carcinoma445225.1555.440.3412.69e-05NS
KIRCKidney renal clear cell carcinoma725346.3085.932-0.3614.31e-11NS
KIRPKidney renal papillary cell carcinoma322916.1575.831-0.3190.000278NS
LAMLAcute Myeloid Leukemia0173NA5.66NANANA
LGGBrain Lower Grade Glioma0530NA6.149NANANA
LIHCLiver hepatocellular carcinoma503735.4725.4490.0180.892NS
LUADLung adenocarcinoma595175.8135.741-0.010.901NS
LUSCLung squamous cell carcinoma515015.6585.7910.1430.0514NS
OVOvarian serous cystadenocarcinoma0307NA6.454NANANA
PAADPancreatic adenocarcinoma41795.5085.38NANANA
PCPGPheochromocytoma and Paraganglioma31845.2725.438NANANA
PRADProstate adenocarcinoma524985.3645.262-0.2270.000215NS
READRectum adenocarcinoma101675.4085.7780.3270.225NS
SARCSarcoma22635.8885.844NANANA
SKCMSkin Cutaneous Melanoma14725.5165.601NANANA
STADStomach adenocarcinoma354155.2075.6080.3920.000297NS
TGCTTesticular Germ Cell Tumors0156NA5.635NANANA
THCAThyroid carcinoma595096.3396.5320.1750.00326NS
THYMThymoma21206.045.87NANANA
UCECUterine Corpus Endometrial Carcinoma355466.0815.831-0.2930.0201NS
> Cancer Cell Line Encyclopedia (CCLE)
 

There is no record.
> The Human Protein Atlas (HPA)
 


Tissue Expression Level (TPM)
Adipose tissue 20.1
Adrenal gland 21.8
Appendix 28.5
Bone marrow 27.4
Breast 22.5
Cerebral cortex 46
Cervix, uterine 28.5
Colon 19.5
Duodenum 18.1
Endometrium 44.5
Epididymis 49
Esophagus 18.7
Fallopian tube 37.1
Gallbladder 25.1
Heart muscle 13.8
Kidney 35.8
Liver 20.7
Lung 30.1
Lymph node 26.4
Ovary 33.9
Pancreas 2.8
Parathyroid gland 54.5
Placenta 44.1
Prostate 26.6
Rectum 21.5
Salivary gland 6.2
Seminal vesicle 30
Skeletal muscle 3.4
Skin 27.9
Small intestine 21.9
Smooth muscle 30.6
Spleen 39.1
Stomach 16.5
Testis 36.6
Thyroid gland 50.9
Tonsil 20.9
Urinary bladder 20.7
> Text Mining based Expression
 
There is no record.
Summary
SymbolFMR1
Namefragile X mental retardation 1
Aliases FMRP; MGC87458; POF1; premature ovarian failure 1; Protein FMR-1; Fragile X mental retardation protein 1
LocationXq27.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Somatic copy number alteration in primary tomur tissue
> The Cancer Genome Atlas (TCGA)
 


  Correlation between expression and SCNA as well as percentage of patients in different status.
Cancer Full Name # Sample R P % Loss % Neutral % Gain Status
BLCABladder urothelial carcinoma4040.3281.31e-1118.365.116.6Neutral
BRCABreast invasive carcinoma10750.1876.34e-1017.366.316.4Neutral
CESCCervical and endocervical cancers2920.3651.24e-1019.957.222.9Neutral
COADColon adenocarcinoma4490.0410.39111.868.819.4Neutral
ESCAEsophageal carcinoma1830.4882.36e-1213.750.336.1Gain
GBMGlioblastoma multiforme1470.2730.00081423.168.78.2Neutral
HNSCHead and Neck squamous cell carcinoma5140.3013.13e-1210.762.826.5Neutral
KIRCKidney renal clear cell carcinoma5250.0640.1410.1845.9Neutral
KIRPKidney renal papillary cell carcinoma288-0.0470.439.45832.6Neutral
LAMLAcute Myeloid Leukemia166-0.0740.3443.695.80.6Neutral
LGGBrain Lower Grade Glioma5130.2677.46e-1016.6758.4Neutral
LIHCLiver hepatocellular carcinoma3640.342.62e-111761.521.4Neutral
LUADLung adenocarcinoma5120.3348.61e-158.863.327.9Neutral
LUSCLung squamous cell carcinoma4980.4271.84e-2320.357.622.1Neutral
OVOvarian serous cystadenocarcinoma3000.1890.00136.727.336Gain
PAADPancreatic adenocarcinoma1770.4032.69e-0810.278.511.3Neutral
PCPGPheochromocytoma and Paraganglioma162-0.2420.001932.764.23.1Neutral
PRADProstate adenocarcinoma4910.4791.79e-297.5902.4Neutral
READRectum adenocarcinoma1640.0550.48215.962.821.3Neutral
SARCSarcoma2550.2360.00013847.539.213.3Loss
SKCMSkin Cutaneous Melanoma3670.1220.019424.560.515Neutral
STADStomach adenocarcinoma4130.4587.61e-2310.971.717.4Neutral
TGCTTesticular Germ Cell Tumors1500.2230.006192065.314.7Neutral
THCAThyroid carcinoma4970.0580.1970.897.41.8Neutral
THYMThymoma1190.4941.11e-082.590.86.7Neutral
UCECUterine Corpus Endometrial Carcinoma5370.1660.00010913.671.315.1Neutral
Summary
SymbolFMR1
Namefragile X mental retardation 1
Aliases FMRP; MGC87458; POF1; premature ovarian failure 1; Protein FMR-1; Fragile X mental retardation protein 1
LocationXq27.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Methylation level in the promoter region of CR
> Methylation level in the promoter region of CR
 


  Correlation between expression and methylation as well as differential methylation analysis.
Cancer Full Name R P # N # T Delta beta (T vs N) P value (T vs N) Status
BLCABladder urothelial carcinoma-0.2541.27e-0717408-0.0030.0851NS/NA
BRCABreast invasive carcinoma-0.351083785-0.077.59e-22NS/NA
CESCCervical and endocervical cancers-0.3484.04e-103306NANANS/NA
COADColon adenocarcinoma-0.3434.97e-1019297-0.0560.0149NS/NA
ESCAEsophageal carcinoma-0.3573.75e-079185NANANS/NA
GBMGlioblastoma multiforme-0.1690.178164NANANS/NA
HNSCHead and Neck squamous cell carcinoma-0.236.93e-0820522-0.0160.546NS/NA
KIRCKidney renal clear cell carcinoma-0.1570.00362243190.0620.105NS/NA
KIRPKidney renal papillary cell carcinoma-0.1090.0596232750.0750.745NS/NA
LAMLAcute Myeloid Leukemia-0.1020.1840170NANANS/NA
LGGBrain Lower Grade Glioma-0.1110.01030530NANANS/NA
LIHCLiver hepatocellular carcinoma-0.3298.79e-1241373-0.0760.00162NS/NA
LUADLung adenocarcinoma-0.1942.15e-05214560.0590.963NS/NA
LUSCLung squamous cell carcinoma-0.2451.58e-068370NANANS/NA
OVOvarian serous cystadenocarcinoma-0.350.35909NANANS/NA
PAADPancreatic adenocarcinoma-0.1460.0484179NANANS/NA
PCPGPheochromocytoma and Paraganglioma-0.0650.3793184NANANS/NA
PRADProstate adenocarcinoma-0.1020.0182354980.0432.61e-25NS/NA
READRectum adenocarcinoma-0.2060.0394299NANANS/NA
SARCSarcoma-0.0810.1920263NANANS/NA
SKCMSkin Cutaneous Melanoma-0.1942.19e-051471NANANS/NA
STADStomach adenocarcinoma-0.1810.000470372NANANS/NA
TGCTTesticular Germ Cell Tumors-0.20.01230156NANANS/NA
THCAThyroid carcinoma-0.1190.0049950509-0.0230.318NS/NA
THYMThymoma-0.040.6632120NANANS/NA
UCECUterine Corpus Endometrial Carcinoma-0.3023.41e-1134431-0.020.00348NS/NA
Summary
SymbolFMR1
Namefragile X mental retardation 1
Aliases FMRP; MGC87458; POF1; premature ovarian failure 1; Protein FMR-1; Fragile X mental retardation protein 1
LocationXq27.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Primary tumor tissue from TCGA
> Normal tumor tissue from HPA
>The Cancer Genome Atlas (TCGA)
 
There is no record.
> The Human Protein Atlas (HPA)
 


Tissue Level Level Name
Adrenal gland 2 Medium
Appendix 2 Medium
Bone marrow 1 Low
Breast 2 Medium
Bronchus 2 Medium
Caudate 2 Medium
Cerebellum 3 High
Cerebral cortex 3 High
Cervix, uterine 2 Medium
Colon 2 Medium
Duodenum 2 Medium
Endometrium 2 Medium
Epididymis 3 High
Esophagus 2 Medium
Fallopian tube 3 High
Gallbladder 2 Medium
Heart muscle 1 Low
Hippocampus 3 High
Kidney 3 High
Liver 1 Low
Lung 3 High
Lymph node 1 Low
Nasopharynx 3 High
Oral mucosa 2 Medium
Ovary 2 Medium
Pancreas 2 Medium
Parathyroid gland 1 Low
Placenta 3 High
Prostate 2 Medium
Rectum 2 Medium
Salivary gland 2 Medium
Seminal vesicle 3 High
Skeletal muscle 2 Medium
Skin 2 Medium
Small intestine 3 High
Smooth muscle 2 Medium
Soft tissue 2 Medium
Spleen 1 Low
Stomach 2 Medium
Testis 3 High
Thyroid gland 2 Medium
Tonsil 2 Medium
Urinary bladder 3 High
Vagina 2 Medium
Summary
SymbolFMR1
Namefragile X mental retardation 1
Aliases FMRP; MGC87458; POF1; premature ovarian failure 1; Protein FMR-1; Fragile X mental retardation protein 1
LocationXq27.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Association between expresson and subtype
> Overall survival analysis based on expression
> Association between expresson and stage
> Association between expresson and grade
> Subtype
 


  Association between expresson and subtype.
Cancer Full Name # Patients P Value (Kruskal-Wallis) Association Source
BLCABladder urothelial carcinoma1280.651NS24476821
BRCABreast invasive carcinoma5213.39e-14Significant23000897
COADColon adenocarcinoma1490.0166Significant22810696
GBMGlioblastoma multiforme1570.00589Significant26824661
HNSCHead and Neck squamous cell carcinoma2790.00932Significant25631445
KIRPKidney renal papillary cell carcinoma1610.534NS26536169
LGGBrain Lower Grade Glioma5133.12e-18Significant26824661
LUADLung adenocarcinoma2300.206NS25079552
LUSCLung squamous cell carcinoma1781.68e-06Significant22960745
OVOvarian serous cystadenocarcinoma2875.57e-06Significant21720365
PRADProstate adenocarcinoma3330.0531NS26544944
READRectum adenocarcinoma670.303NS22810696
SKCMSkin Cutaneous Melanoma3150.0397Significant26091043
STADStomach adenocarcinoma2772.34e-05Significant25079317
THCAThyroid carcinoma3911.6e-10Significant25417114
UCECUterine Corpus Endometrial Carcinoma2321.25e-05Significant23636398
> Overall survival
 

  Overall survival analysis based on expression.
Cancer Full Name # Patients Hazard Ratio P Value (Log Rank Test) Association
BLCABladder urothelial carcinoma405 1.0880.676NS
BRCABreast invasive carcinoma1079 1.1570.524NS
CESCCervical and endocervical cancers291 0.3180.000871Longer
COADColon adenocarcinoma439 0.5960.115NS
ESCAEsophageal carcinoma184 2.0880.0301Shorter
GBMGlioblastoma multiforme158 0.6930.149NS
HNSCHead and Neck squamous cell carcinoma518 0.9050.609NS
KIRCKidney renal clear cell carcinoma531 0.7410.189NS
KIRPKidney renal papillary cell carcinoma287 2.6060.0333Shorter
LAMLAcute Myeloid Leukemia149 1.1160.696NS
LGGBrain Lower Grade Glioma511 0.5720.0229Longer
LIHCLiver hepatocellular carcinoma365 0.6070.0525NS
LUADLung adenocarcinoma502 0.830.361NS
LUSCLung squamous cell carcinoma494 0.7320.115NS
OVOvarian serous cystadenocarcinoma303 0.9030.631NS
PAADPancreatic adenocarcinoma177 1.1660.584NS
PCPGPheochromocytoma and Paraganglioma179 00.355NS
PRADProstate adenocarcinoma497 2081120143.9260.0112Shorter
READRectum adenocarcinoma159 0.8850.869NS
SARCSarcoma259 1.0330.913NS
SKCMSkin Cutaneous Melanoma459 0.6950.057NS
STADStomach adenocarcinoma388 0.8260.406NS
TGCTTesticular Germ Cell Tumors134 0.9130.949NS
THCAThyroid carcinoma500 0.2240.0428Longer
THYMThymoma119 0.8830.892NS
UCECUterine Corpus Endometrial Carcinoma543 2.4190.00269Shorter
> Stage
 

  Association between expresson and stage.
Cancer Full Name # Patients R Value (Spearman) P Value (Spearman) Association
BLCABladder urothelial carcinoma406 -0.0450.37NS
BRCABreast invasive carcinoma1071 -0.0150.624NS
CESCCervical and endocervical cancers167 0.0350.655NS
COADColon adenocarcinoma445 -0.0420.375NS
ESCAEsophageal carcinoma162 0.0910.249NS
HNSCHead and Neck squamous cell carcinoma448 0.0020.96NS
KIRCKidney renal clear cell carcinoma531 -0.0410.343NS
KIRPKidney renal papillary cell carcinoma260 0.0950.128NS
LIHCLiver hepatocellular carcinoma347 -0.1090.0424Lower
LUADLung adenocarcinoma507 -0.0570.201NS
LUSCLung squamous cell carcinoma497 0.0360.428NS
OVOvarian serous cystadenocarcinoma302 0.0170.769NS
PAADPancreatic adenocarcinoma176 0.0430.569NS
READRectum adenocarcinoma156 -0.0070.935NS
SKCMSkin Cutaneous Melanoma410 -0.0910.0653NS
STADStomach adenocarcinoma392 0.020.695NS
TGCTTesticular Germ Cell Tumors81 -0.1420.205NS
THCAThyroid carcinoma499 0.0080.866NS
UCECUterine Corpus Endometrial Carcinoma501 0.1210.00658Higher
> Grade
 

  Association between expresson and grade.
Cancer Full Name # Patients R Value (Spearman) P Value (Spearman) Association
CESCCervical and endocervical cancers272 -0.0460.446NS
HNSCHead and Neck squamous cell carcinoma498 0.1030.0215Higher
KIRCKidney renal clear cell carcinoma525 -0.0660.134NS
LGGBrain Lower Grade Glioma514 -0.2347.96e-08Lower
LIHCLiver hepatocellular carcinoma366 -0.1190.0224Lower
OVOvarian serous cystadenocarcinoma296 0.1250.0322Higher
PAADPancreatic adenocarcinoma176 0.030.691NS
STADStomach adenocarcinoma406 -0.090.0697NS
UCECUterine Corpus Endometrial Carcinoma534 0.2935.03e-12Higher
Summary
SymbolFMR1
Namefragile X mental retardation 1
Aliases FMRP; MGC87458; POF1; premature ovarian failure 1; Protein FMR-1; Fragile X mental retardation protein 1
LocationXq27.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Targets inferred by reverse engineering method
> Targets identified by ChIP-seq data
> Targets inferred by reverse engineering method
 
> Targets identified by ChIP-seq data
 
Summary
SymbolFMR1
Namefragile X mental retardation 1
Aliases FMRP; MGC87458; POF1; premature ovarian failure 1; Protein FMR-1; Fragile X mental retardation protein 1
LocationXq27.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Drugs from DrugBank database
> Drugs from DrugBank database
 
There is no record for FMR1.
Summary
SymbolFMR1
Namefragile X mental retardation 1
Aliases FMRP; MGC87458; POF1; premature ovarian failure 1; Protein FMR-1; Fragile X mental retardation protein 1
LocationXq27.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Protein-Protein Interaction Network
> miRNA Regulatory Relationship
> Interactions from Text Mining
> Protein-Protein Interaction Network
 
> miRNA Regulatory Relationship
 
> Interactions from Text Mining
 
There is no record for FMR1.