CR2Cancer

Summary
Symbol	HDAC1
Name	histone deacetylase 1
Aliases	GON-10; RPD3L1; reduced potassium dependency, yeast homolog-like 1
Location	1p35.2-p35.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

[ TOP ]

Domain

PF00850 Histone deacetylase domain

Function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation.

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification erase	Histone acetylation	H3, H4	#	10220385

> Gene Ontology [ TOP ]
Biological Process	GO:0001654 eye development GO:0001819 positive regulation of cytokine production GO:0001942 hair follicle development GO:0001975 response to amphetamine GO:0002237 response to molecule of bacterial origin GO:0002790 peptide secretion GO:0002791 regulation of peptide secretion GO:0002792 negative regulation of peptide secretion GO:0006338 chromatin remodeling GO:0006342 chromatin silencing GO:0006346 methylation-dependent chromatin silencing GO:0006473 protein acetylation GO:0006476 protein deacetylation GO:0006979 response to oxidative stress GO:0007259 JAK-STAT cascade GO:0007260 tyrosine phosphorylation of STAT protein GO:0007423 sensory organ development GO:0007596 blood coagulation GO:0007599 hemostasis GO:0007623 circadian rhythm GO:0008544 epidermis development GO:0009306 protein secretion GO:0009755 hormone-mediated signaling pathway GO:0009913 epidermal cell differentiation GO:0009914 hormone transport GO:0010001 glial cell differentiation GO:0010720 positive regulation of cell development GO:0010817 regulation of hormone levels GO:0010869 regulation of receptor biosynthetic process GO:0010870 positive regulation of receptor biosynthetic process GO:0014013 regulation of gliogenesis GO:0014015 positive regulation of gliogenesis GO:0014074 response to purine-containing compound GO:0014075 response to amine GO:0015833 peptide transport GO:0016055 Wnt signaling pathway GO:0016458 gene silencing GO:0016570 histone modification GO:0016575 histone deacetylation GO:0018108 peptidyl-tyrosine phosphorylation GO:0018205 peptidyl-lysine modification GO:0018212 peptidyl-tyrosine modification GO:0018394 peptidyl-lysine acetylation GO:0019058 viral life cycle GO:0019080 viral gene expression GO:0019083 viral transcription GO:0022404 molting cycle process GO:0022405 hair cycle process GO:0023061 signal release GO:0030072 peptide hormone secretion GO:0030073 insulin secretion GO:0030111 regulation of Wnt signaling pathway GO:0030178 negative regulation of Wnt signaling pathway GO:0030326 embryonic limb morphogenesis GO:0030518 intracellular steroid hormone receptor signaling pathway GO:0030521 androgen receptor signaling pathway GO:0030522 intracellular receptor signaling pathway GO:0031000 response to caffeine GO:0032496 response to lipopolysaccharide GO:0032602 chemokine production GO:0032612 interleukin-1 production GO:0032640 tumor necrosis factor production GO:0032642 regulation of chemokine production GO:0032652 regulation of interleukin-1 production GO:0032680 regulation of tumor necrosis factor production GO:0032722 positive regulation of chemokine production GO:0032732 positive regulation of interleukin-1 production GO:0032760 positive regulation of tumor necrosis factor production GO:0032800 receptor biosynthetic process GO:0032897 negative regulation of viral transcription GO:0032922 circadian regulation of gene expression GO:0033143 regulation of intracellular steroid hormone receptor signaling pathway GO:0033144 negative regulation of intracellular steroid hormone receptor signaling pathway GO:0034599 cellular response to oxidative stress GO:0034612 response to tumor necrosis factor GO:0035107 appendage morphogenesis GO:0035108 limb morphogenesis GO:0035113 embryonic appendage morphogenesis GO:0035601 protein deacylation GO:0035821 modification of morphology or physiology of other organism GO:0036296 response to increased oxygen levels GO:0040029 regulation of gene expression, epigenetic GO:0042063 gliogenesis GO:0042303 molting cycle GO:0042475 odontogenesis of dentin-containing tooth GO:0042476 odontogenesis GO:0042493 response to drug GO:0042503 tyrosine phosphorylation of Stat3 protein GO:0042509 regulation of tyrosine phosphorylation of STAT protein GO:0042516 regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein GO:0042633 hair cycle GO:0042733 embryonic digit morphogenesis GO:0042886 amide transport GO:0043010 camera-type eye development GO:0043044 ATP-dependent chromatin remodeling GO:0043112 receptor metabolic process GO:0043279 response to alkaloid GO:0043401 steroid hormone mediated signaling pathway GO:0043523 regulation of neuron apoptotic process GO:0043524 negative regulation of neuron apoptotic process GO:0043543 protein acylation GO:0043586 tongue development GO:0043587 tongue morphogenesis GO:0043588 skin development GO:0043900 regulation of multi-organism process GO:0043901 negative regulation of multi-organism process GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism GO:0043921 modulation by host of viral transcription GO:0043922 negative regulation by host of viral transcription GO:0044033 multi-organism metabolic process GO:0045685 regulation of glial cell differentiation GO:0045687 positive regulation of glial cell differentiation GO:0045814 negative regulation of gene expression, epigenetic GO:0046425 regulation of JAK-STAT cascade GO:0046427 positive regulation of JAK-STAT cascade GO:0046676 negative regulation of insulin secretion GO:0046782 regulation of viral transcription GO:0046879 hormone secretion GO:0046883 regulation of hormone secretion GO:0046888 negative regulation of hormone secretion GO:0048511 rhythmic process GO:0048525 negative regulation of viral process GO:0048545 response to steroid hormone GO:0048709 oligodendrocyte differentiation GO:0048713 regulation of oligodendrocyte differentiation GO:0048714 positive regulation of oligodendrocyte differentiation GO:0048736 appendage development GO:0050708 regulation of protein secretion GO:0050709 negative regulation of protein secretion GO:0050730 regulation of peptidyl-tyrosine phosphorylation GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation GO:0050769 positive regulation of neurogenesis GO:0050792 regulation of viral process GO:0050796 regulation of insulin secretion GO:0050817 coagulation GO:0050878 regulation of body fluid levels GO:0051048 negative regulation of secretion GO:0051051 negative regulation of transport GO:0051224 negative regulation of protein transport GO:0051402 neuron apoptotic process GO:0051702 interaction with symbiont GO:0051817 modification of morphology or physiology of other organism involved in symbiotic interaction GO:0051851 modification by host of symbiont morphology or physiology GO:0051962 positive regulation of nervous system development GO:0052312 modulation of transcription in other organism involved in symbiotic interaction GO:0052472 modulation by host of symbiont transcription GO:0055093 response to hyperoxia GO:0060070 canonical Wnt signaling pathway GO:0060173 limb development GO:0060765 regulation of androgen receptor signaling pathway GO:0060766 negative regulation of androgen receptor signaling pathway GO:0060788 ectodermal placode formation GO:0060789 hair follicle placode formation GO:0060828 regulation of canonical Wnt signaling pathway GO:0061029 eyelid development in camera-type eye GO:0061196 fungiform papilla development GO:0061197 fungiform papilla morphogenesis GO:0061198 fungiform papilla formation GO:0070482 response to oxygen levels GO:0070932 histone H3 deacetylation GO:0070933 histone H4 deacetylation GO:0070997 neuron death GO:0071356 cellular response to tumor necrosis factor GO:0071383 cellular response to steroid hormone stimulus GO:0071396 cellular response to lipid GO:0071407 cellular response to organic cyclic compound GO:0071696 ectodermal placode development GO:0071697 ectodermal placode morphogenesis GO:0071706 tumor necrosis factor superfamily cytokine production GO:0072331 signal transduction by p53 class mediator GO:0072567 chemokine (C-X-C motif) ligand 2 production GO:0090087 regulation of peptide transport GO:0090090 negative regulation of canonical Wnt signaling pathway GO:0090276 regulation of peptide hormone secretion GO:0090278 negative regulation of peptide hormone secretion GO:0090596 sensory organ morphogenesis GO:0097050 type B pancreatic cell apoptotic process GO:0097696 STAT cascade GO:0098732 macromolecule deacylation GO:0098773 skin epidermis development GO:0198738 cell-cell signaling by wnt GO:1901214 regulation of neuron death GO:1901215 negative regulation of neuron death GO:1901796 regulation of signal transduction by p53 class mediator GO:1901983 regulation of protein acetylation GO:1901984 negative regulation of protein acetylation GO:1903531 negative regulation of secretion by cell GO:1903555 regulation of tumor necrosis factor superfamily cytokine production GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production GO:1903900 regulation of viral life cycle GO:1903901 negative regulation of viral life cycle GO:1904019 epithelial cell apoptotic process GO:1904035 regulation of epithelial cell apoptotic process GO:1904037 positive regulation of epithelial cell apoptotic process GO:1904837 beta-catenin-TCF complex assembly GO:1904892 regulation of STAT cascade GO:1904894 positive regulation of STAT cascade GO:1904950 negative regulation of establishment of protein localization GO:2000341 regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000674 regulation of type B pancreatic cell apoptotic process GO:2000676 positive regulation of type B pancreatic cell apoptotic process GO:2000756 regulation of peptidyl-lysine acetylation GO:2000757 negative regulation of peptidyl-lysine acetylation
Molecular Function	GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000987 core promoter proximal region sequence-specific DNA binding GO:0001047 core promoter binding GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding GO:0001085 RNA polymerase II transcription factor binding GO:0001103 RNA polymerase II repressing transcription factor binding GO:0001104 RNA polymerase II transcription cofactor activity GO:0001106 RNA polymerase II transcription corepressor activity GO:0001158 enhancer sequence-specific DNA binding GO:0001159 core promoter proximal region DNA binding GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding GO:0003682 chromatin binding GO:0003714 transcription corepressor activity GO:0004407 histone deacetylase activity GO:0008134 transcription factor binding GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides GO:0017136 NAD-dependent histone deacetylase activity GO:0019213 deacetylase activity GO:0031078 histone deacetylase activity (H3-K14 specific) GO:0031490 chromatin DNA binding GO:0031491 nucleosome binding GO:0031492 nucleosomal DNA binding GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific) GO:0033558 protein deacetylase activity GO:0033613 activating transcription factor binding GO:0034979 NAD-dependent protein deacetylase activity GO:0035326 enhancer binding GO:0042826 histone deacetylase binding GO:0043566 structure-specific DNA binding GO:0047485 protein N-terminus binding GO:0051059 NF-kappaB binding GO:0070491 repressing transcription factor binding
Cellular Component	GO:0000118 histone deacetylase complex GO:0000785 chromatin GO:0000790 nuclear chromatin GO:0016580 Sin3 complex GO:0016581 NuRD complex GO:0017053 transcriptional repressor complex GO:0044454 nuclear chromosome part GO:0070603 SWI/SNF superfamily-type complex GO:0070822 Sin3-type complex GO:0090545 CHD-type complex GO:0090568 nuclear transcriptional repressor complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04110 Cell cycle hsa04330 Notch signaling pathway hsa04919 Thyroid hormone signaling pathway
Reactome	R-HSA-1640170: Cell Cycle R-HSA-69278: Cell Cycle, Mitotic R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-2894862: Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2644606: Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-3769402: Deactivation of the beta-catenin transactivating complex R-HSA-195253: Degradation of beta-catenin by the destruction complex R-HSA-1643685: Disease R-HSA-5663202: Diseases of signal transduction R-HSA-2173795: Downregulation of SMAD2/3 R-HSA-427389: ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-212165: Epigenetic regulation of gene expression R-HSA-983231: Factors involved in megakaryocyte development and platelet production R-HSA-201722: Formation of the beta-catenin R-HSA-1538133: G0 and Early G1 R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-3214815: HDACs deacetylate histones R-HSA-109582: Hemostasis R-HSA-453279: Mitotic G1-G1/S phases R-HSA-2122947: NOTCH1 Intracellular Domain Regulates Transcription R-HSA-5250941: Negative epigenetic regulation of rRNA expression R-HSA-427413: NoRC negatively regulates rRNA expression R-HSA-5250913: Positive epigenetic regulation of rRNA expression R-HSA-73854: RNA Polymerase I Promoter Clearance R-HSA-73864: RNA Polymerase I Transcription R-HSA-73762: RNA Polymerase I Transcription Initiation R-HSA-504046: RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription R-HSA-5633007: Regulation of TP53 Activity R-HSA-6804758: Regulation of TP53 Activity through Acetylation R-HSA-4641265: Repression of WNT target genes R-HSA-2173796: SMAD2/SMAD3 R-HSA-162582: Signal Transduction R-HSA-157118: Signaling by NOTCH R-HSA-1980143: Signaling by NOTCH1 R-HSA-2894858: Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2644602: Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644603: Signaling by NOTCH1 in Cancer R-HSA-170834: Signaling by TGF-beta Receptor Complex R-HSA-195721: Signaling by Wnt R-HSA-166520: Signalling by NGF R-HSA-201681: TCF dependent signaling in response to WNT R-HSA-3700989: Transcriptional Regulation by TP53 R-HSA-2173793: Transcriptional activity of SMAD2/SMAD3 R-HSA-193704: p75 NTR receptor-mediated signalling R-HSA-193670: p75NTR negatively regulates cell cycle via SC1

> KEGG and Reactome Pathway

[ TOP ]

KEGG

hsa04110 Cell cycle
hsa04330 Notch signaling pathway
hsa04919 Thyroid hormone signaling pathway

Reactome

R-HSA-1640170: Cell Cycle
R-HSA-69278: Cell Cycle, Mitotic
R-HSA-3247509: Chromatin modifying enzymes
R-HSA-4839726: Chromatin organization
R-HSA-2894862: Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
R-HSA-2644606: Constitutive Signaling by NOTCH1 PEST Domain Mutants
R-HSA-3769402: Deactivation of the beta-catenin transactivating complex
R-HSA-195253: Degradation of beta-catenin by the destruction complex
R-HSA-1643685: Disease
R-HSA-5663202: Diseases of signal transduction
R-HSA-2173795: Downregulation of SMAD2/3
R-HSA-427389: ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
R-HSA-212165: Epigenetic regulation of gene expression
R-HSA-983231: Factors involved in megakaryocyte development and platelet production
R-HSA-201722: Formation of the beta-catenin
R-HSA-1538133: G0 and Early G1
R-HSA-74160: Gene Expression
R-HSA-212436: Generic Transcription Pathway
R-HSA-3214815: HDACs deacetylate histones
R-HSA-109582: Hemostasis
R-HSA-453279: Mitotic G1-G1/S phases
R-HSA-2122947: NOTCH1 Intracellular Domain Regulates Transcription
R-HSA-5250941: Negative epigenetic regulation of rRNA expression
R-HSA-427413: NoRC negatively regulates rRNA expression
R-HSA-5250913: Positive epigenetic regulation of rRNA expression
R-HSA-73854: RNA Polymerase I Promoter Clearance
R-HSA-73864: RNA Polymerase I Transcription
R-HSA-73762: RNA Polymerase I Transcription Initiation
R-HSA-504046: RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
R-HSA-5633007: Regulation of TP53 Activity
R-HSA-6804758: Regulation of TP53 Activity through Acetylation
R-HSA-4641265: Repression of WNT target genes
R-HSA-2173796: SMAD2/SMAD3
R-HSA-162582: Signal Transduction
R-HSA-157118: Signaling by NOTCH
R-HSA-1980143: Signaling by NOTCH1
R-HSA-2894858: Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
R-HSA-2644602: Signaling by NOTCH1 PEST Domain Mutants in Cancer
R-HSA-2644603: Signaling by NOTCH1 in Cancer
R-HSA-170834: Signaling by TGF-beta Receptor Complex
R-HSA-195721: Signaling by Wnt
R-HSA-166520: Signalling by NGF
R-HSA-201681: TCF dependent signaling in response to WNT
R-HSA-3700989: Transcriptional Regulation by TP53
R-HSA-2173793: Transcriptional activity of SMAD2/SMAD3
R-HSA-193704: p75 NTR receptor-mediated signalling
R-HSA-193670: p75NTR negatively regulates cell cycle via SC1

Summary
Symbol	HDAC1
Name	histone deacetylase 1
Aliases	GON-10; RPD3L1; reduced potassium dependency, yeast homolog-like 1
Location	1p35.2-p35.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM222521	c.1363G>A	p.E455K	Substitution - Missense	Skin
COSM426102	c.1422G>A	p.G474G	Substitution - coding silent	Breast
COSM3785261	c.1372+9G>A	p.?	Unknown	Pancreas
COSM5457671	c.7C>T	p.Q3*	Substitution - Nonsense	Large_intestine
COSM4031484	c.609G>T	p.E203D	Substitution - Missense	Stomach
COSM5456384	c.119A>T	p.N40I	Substitution - Missense	Large_intestine
COSM1492053	c.1162G>A	p.A388T	Substitution - Missense	Kidney
COSM908301	c.1397_1399delAGG	p.E468delE	Deletion - In frame	Endometrium
COSM1492053	c.1162G>A	p.A388T	Substitution - Missense	Lung
COSM1473866	c.1335_1336delAG	p.E446fs*2	Deletion - Frameshift	Breast
COSM4031487	c.922G>A	p.V308I	Substitution - Missense	Stomach
COSM5962325	c.1193A>G	p.E398G	Substitution - Missense	Breast
COSM212337	c.418C>T	p.H140Y	Substitution - Missense	Breast
COSM5822492	c.888G>A	p.L296L	Substitution - coding silent	Liver
COSM5969358	c.766G>A	p.A256T	Substitution - Missense	Upper_aerodigestive_tract
COSM1473867	c.1422-2A>T	p.?	Unknown	Large_intestine
COSM5955122	c.543C>T	p.D181D	Substitution - coding silent	Upper_aerodigestive_tract
COSM1748353	c.943G>A	p.E315K	Substitution - Missense	Urinary_tract
COSM304443	c.1292G>A	p.R431H	Substitution - Missense	Large_intestine
COSM5667333	c.691G>T	p.G231W	Substitution - Missense	Soft_tissue
COSM908301	c.1397_1399delAGG	p.E468delE	Deletion - In frame	Large_intestine
COSM161470	c.1192G>A	p.E398K	Substitution - Missense	Breast
COSM4509064	c.795C>T	p.S265S	Substitution - coding silent	Skin
COSM908298	c.932G>A	p.C311Y	Substitution - Missense	Endometrium
COSM6006515	c.885G>A	p.M295I	Substitution - Missense	Prostate
COSM908299	c.1191C>T	p.D397D	Substitution - coding silent	Endometrium
COSM908300	c.1360_1362delGAG	p.E455delE	Deletion - In frame	Endometrium
COSM426100	c.50-2A>G	p.?	Unknown	Breast
COSM6006516	c.1168C>T	p.P390S	Substitution - Missense	Prostate
COSM3419121	c.92A>C	p.K31T	Substitution - Missense	Large_intestine
COSM3386088	c.809G>A	p.R270Q	Substitution - Missense	Pancreas
COSM908296	c.240T>C	p.R80R	Substitution - coding silent	Endometrium
COSM4439827	c.1093C>T	p.R365*	Substitution - Nonsense	Thyroid
COSM3488159	c.750G>A	p.E250E	Substitution - coding silent	Skin
COSM1194937	c.229C>T	p.R77C	Substitution - Missense	Lung
COSM1296292	c.1090C>T	p.Q364*	Substitution - Nonsense	Urinary_tract
COSM1602217	c.839-2A>G	p.?	Unknown	Liver
COSM3488160	c.756C>T	p.F252F	Substitution - coding silent	Skin
COSM5433390	c.1104G>A	p.E368E	Substitution - coding silent	Oesophagus
COSM2077934	c.844G>A	p.A282T	Substitution - Missense	Large_intestine
COSM5599661	c.234C>T	p.S78S	Substitution - coding silent	Skin
COSM2077921	c.436G>A	p.E146K	Substitution - Missense	Stomach
COSM3771725	c.341C>T	p.T114I	Substitution - Missense	Pancreas
COSM5984051	c.1186G>A	p.E396K	Substitution - Missense	Upper_aerodigestive_tract
COSM4891479	c.1089-1G>A	p.?	Unknown	Upper_aerodigestive_tract
COSM5911361	c.52G>A	p.D18N	Substitution - Missense	Skin
COSM2077915	c.232T>C	p.S78P	Substitution - Missense	Large_intestine
COSM908301	c.1397_1399delAGG	p.E468delE	Deletion - In frame	Large_intestine
COSM5696355	c.838+3G>A	p.?	Unknown	Soft_tissue
COSM161470	c.1192G>A	p.E398K	Substitution - Missense	Breast
COSM1492053	c.1162G>A	p.A388T	Substitution - Missense	Liver
COSM5599661	c.234C>T	p.S78S	Substitution - coding silent	Skin
COSM5454217	c.494+2T>C	p.?	Unknown	Large_intestine
COSM464440	c.258G>C	p.E86D	Substitution - Missense	Kidney
COSM94441	c.1291C>T	p.R431C	Substitution - Missense	Lung
COSM2077938	c.1126G>A	p.A376T	Substitution - Missense	Breast
COSM908297	c.767C>T	p.A256V	Substitution - Missense	Endometrium
COSM3785261	c.1372+9G>A	p.?	Unknown	Pancreas
COSM1241244	c.281-2A>T	p.?	Unknown	Oesophagus
COSM1748353	c.943G>A	p.E315K	Substitution - Missense	Urinary_tract
COSM1602216	c.183T>A	p.A61A	Substitution - coding silent	Liver
COSM1602216	c.183T>A	p.A61A	Substitution - coding silent	Liver
COSM5992838	c.1106A>G	p.N369S	Substitution - Missense	Prostate
COSM908301	c.1397_1399delAGG	p.E468delE	Deletion - In frame	Large_intestine
COSM5891305	c.590C>T	p.S197F	Substitution - Missense	Skin
COSM5599661	c.234C>T	p.S78S	Substitution - coding silent	Skin
COSM3386087	c.162T>C	p.Y54Y	Substitution - coding silent	Pancreas
COSM3360847	c.1023C>G	p.F341L	Substitution - Missense	Kidney
COSM94440	c.1094G>A	p.R365Q	Substitution - Missense	Breast
COSM681102	c.1188G>C	p.E396D	Substitution - Missense	Lung
COSM908301	c.1397_1399delAGG	p.E468delE	Deletion - In frame	Biliary_tract
COSM5992838	c.1106A>G	p.N369S	Substitution - Missense	Prostate
COSM4689660	c.691G>A	p.G231R	Substitution - Missense	Large_intestine
COSM5599661	c.234C>T	p.S78S	Substitution - coding silent	Skin
COSM4031485	c.618A>G	p.P206P	Substitution - coding silent	Stomach
COSM4403594	c.637-1G>A	p.?	Unknown	Skin
COSM5380655	c.1218G>A	p.S406S	Substitution - coding silent	Skin
COSM71028	c.74G>C	p.G25A	Substitution - Missense	Ovary
COSM426101	c.1135G>T	p.V379F	Substitution - Missense	Breast
COSM1473864	c.504G>A	p.Q168Q	Substitution - coding silent	Breast
COSM908294	c.101G>A	p.R34Q	Substitution - Missense	Endometrium
COSM3488161	c.1103A>G	p.E368G	Substitution - Missense	Skin
COSM5769831	c.514T>C	p.Y172H	Substitution - Missense	Breast
COSM1473865	c.966G>T	p.T322T	Substitution - coding silent	Breast
COSM3419122	c.664T>G	p.Y222D	Substitution - Missense	Large_intestine
COSM5892588	c.50G>A	p.G17E	Substitution - Missense	Skin
COSM136112	c.1108C>T	p.L370F	Substitution - Missense	Skin
COSM5585402	c.1386G>A	p.E462E	Substitution - coding silent	Skin
COSM2077913	c.199T>C	p.Y67H	Substitution - Missense	Large_intestine
COSM1341817	c.570G>A	p.T190T	Substitution - coding silent	Large_intestine
COSM5631391	c.394G>A	p.A132T	Substitution - Missense	Oesophagus
COSM908295	c.206G>A	p.S69N	Substitution - Missense	Endometrium
COSM3377121	c.449T>G	p.F150C	Substitution - Missense	Pancreas
COSM908294	c.101G>A	p.R34Q	Substitution - Missense	Large_intestine
COSM4589639	c.839-2_839-1insG	p.?	Unknown	Skin
COSM4391359	c.286G>A	p.V96I	Substitution - Missense	Breast
COSM161471	c.468C>T	p.I156I	Substitution - coding silent	Skin
COSM1194937	c.229C>T	p.R77C	Substitution - Missense	Lung
COSM5599661	c.234C>T	p.S78S	Substitution - coding silent	Skin
COSM2077942	c.1264G>A	p.D422N	Substitution - Missense	Large_intestine
COSM4641805	c.813A>G	p.L271L	Substitution - coding silent	Large_intestine
COSM464441	c.921C>T	p.N307N	Substitution - coding silent	Kidney
COSM2077913	c.199T>C	p.Y67H	Substitution - Missense	Large_intestine
COSM4689659	c.540T>C	p.G180G	Substitution - coding silent	Large_intestine
COSM1602215	c.49+1G>C	p.?	Unknown	Liver
COSM4480017	c.237C>T	p.I79I	Substitution - coding silent	Skin
COSM5620935	c.391A>G	p.I131V	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4031486	c.685C>T	p.R229*	Substitution - Nonsense	Stomach
COSM4638902	c.1381G>A	p.E461K	Substitution - Missense	Large_intestine
COSM681103	c.917G>T	p.R306L	Substitution - Missense	Lung
COSM5892588	c.50G>A	p.G17E	Substitution - Missense	Skin

> Text Mining based Variations

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PMID	Variation	Cancer	Evidence
21685935	Mutation	Nasopharyngeal Carcinoma	The data provided in this report suggest a critical role of EZH2 in the control of cell invasion and/or metastasis by forming a co-repressor complex with HDAC1/HDAC2/Snail to repress E-cadherin, an activity that might be responsible, at least in part, for the development and/or progression of human NPCs.

Summary
Symbol	HDAC1
Name	histone deacetylase 1
Aliases	GON-10; RPD3L1; reduced potassium dependency, yeast homolog-like 1
Location	1p35.2-p35.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

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Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
Q13547	220	K	N6-acetyllysine	-	No	None detected
Q13547	261	C	S-nitrosocysteine	-	No	None detected
Q13547	273	C	S-nitrosocysteine	-	No	None detected
Q13547	393	S	Phosphoserine	-	No	None detected
Q13547	409	S	Phosphoserine	-	No	None detected
Q13547	421	S	Phosphoserine	CK2	No	None detected
Q13547	423	S	Phosphoserine	CK2	No	None detected
Q13547	432	K	N6-methylated lysine	EHMT2	No	None detected

Summary
Symbol	HDAC1
Name	histone deacetylase 1
Aliases	GON-10; RPD3L1; reduced potassium dependency, yeast homolog-like 1
Location	1p35.2-p35.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

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Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	7.21	7.515	0.384	0.00315	NS
BRCA	Breast invasive carcinoma	112	1100	6.512	6.955	0.564	7.7e-26	NS
CESC	Cervical and endocervical cancers	3	306	6.914	7.875	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	8.077	7.994	-0.096	0.198	NS
ESCA	Esophageal carcinoma	11	185	6.284	7.283	0.783	4.13e-05	Over
GBM	Glioblastoma multiforme	5	166	4.49	6.317	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	7.203	7.448	0.396	9.59e-08	NS
KIRC	Kidney renal clear cell carcinoma	72	534	6.761	6.635	-0.258	2.08e-07	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	6.646	6.242	-0.51	2.16e-07	NS
LAML	Acute Myeloid Leukemia	0	173	NA	7.047	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	5.572	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	5.769	6.042	0.309	0.000338	NS
LUAD	Lung adenocarcinoma	59	517	6.315	7.036	0.729	1.25e-25	Over
LUSC	Lung squamous cell carcinoma	51	501	6.351	7.544	1.198	4.58e-44	Over
OV	Ovarian serous cystadenocarcinoma	0	307	NA	7.028	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	6.716	7.231	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	6.448	5.706	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	7.222	7.508	0.369	1.32e-06	NS
READ	Rectum adenocarcinoma	10	167	7.901	7.951	-0.109	0.577	NS
SARC	Sarcoma	2	263	6.597	6.244	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	7.259	6.907	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	7.243	7.378	0.413	0.000487	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	7.047	NA	NA	NA
THCA	Thyroid carcinoma	59	509	7.373	7.582	0.206	0.000203	NS
THYM	Thymoma	2	120	7.499	7.832	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	6.984	7.338	0.417	1.77e-07	NS

> Cancer Cell Line Encyclopedia (CCLE)

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Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	8.5
Autonomic ganglia	CHP212	8.7
Autonomic ganglia	IMR32	8.1
Autonomic ganglia	KELLY	10.3
Autonomic ganglia	KPNRTBM1	8.5
Autonomic ganglia	KPNSI9S	10.2
Autonomic ganglia	KPNYN	8
Autonomic ganglia	MHHNB11	8.6
Autonomic ganglia	NB1	9.4
Autonomic ganglia	NH6	8.2
Autonomic ganglia	SHSY5Y	8.7
Autonomic ganglia	SIMA	9
Autonomic ganglia	SKNAS	9.2
Autonomic ganglia	SKNBE2	8.6
Autonomic ganglia	SKNDZ	9.5
Autonomic ganglia	SKNFI	9.5
Autonomic ganglia	SKNSH	9.9
Biliary tract	HUCCT1	10.4
Biliary tract	HUH28	10.2
Biliary tract	SNU1079	9.7
Biliary tract	SNU1196	10.2
Biliary tract	SNU245	10.3
Biliary tract	SNU308	10.1
Biliary tract	SNU478	10.3
Bone	143B	10.2
Bone	A673	10.8
Bone	CADOES1	10.1
Bone	CAL78	10.5
Bone	G292CLONEA141B1	9.7
Bone	HOS	10.7
Bone	HS706T	9.1
Bone	HS737T	9
Bone	HS819T	8.9
Bone	HS821T	8.9
Bone	HS822T	8.7
Bone	HS863T	9
Bone	HS870T	9.1
Bone	HS888T	9.9
Bone	MG63	10.4
Bone	MHHES1	10.8
Bone	OUMS27	9.6
Bone	RDES	11
Bone	SJSA1	11
Bone	SKES1	11
Bone	SKNMC	10.7
Bone	SW1353	9.9
Bone	T173	8.6
Bone	TC71	11
Bone	U2OS	9.8
Breast	AU565	9.4
Breast	BT20	10.2
Breast	BT474	9.6
Breast	BT483	10.3
Breast	BT549	10.3
Breast	CAL120	10.7
Breast	CAL148	10.1
Breast	CAL51	10.7
Breast	CAL851	10.3
Breast	CAMA1	9.5
Breast	DU4475	10.4
Breast	EFM192A	9.8
Breast	EFM19	10.4
Breast	EVSAT	9.9
Breast	HCC1143	10.3
Breast	HCC1187	10.5
Breast	HCC1395	9.9
Breast	HCC1419	10.4
Breast	HCC1428	11.3
Breast	HCC1500	11.1
Breast	HCC1569	11
Breast	HCC1599	10
Breast	HCC1806	10.8
Breast	HCC1937	10
Breast	HCC1954	9.8
Breast	HCC202	9.7
Breast	HCC2157	10.7
Breast	HCC2218	10.5
Breast	HCC38	11
Breast	HCC70	11.6
Breast	HDQP1	9.7
Breast	HMC18	10.6
Breast	HS274T	9
Breast	HS281T	9.3
Breast	HS343T	9.6
Breast	HS578T	9.8
Breast	HS606T	9.8
Breast	HS739T	9.3
Breast	HS742T	9
Breast	JIMT1	9.8
Breast	KPL1	10.7
Breast	MCF7	10.6
Breast	MDAMB134VI	10.3
Breast	MDAMB157	10.2
Breast	MDAMB175VII	9.5
Breast	MDAMB231	10.3
Breast	MDAMB361	10.3
Breast	MDAMB415	10.6
Breast	MDAMB436	10
Breast	MDAMB453	10.1
Breast	MDAMB468	10.6
Breast	SKBR3	9.8
Breast	T47D	10.1
Breast	UACC812	10.2
Breast	UACC893	10.3
Breast	YMB1	8.3
Breast	ZR751	9.9
Breast	ZR7530	9.7
Central nervous system	1321N1	10.5
Central nervous system	42MGBA	11.3
Central nervous system	8MGBA	11.4
Central nervous system	A172	9.3
Central nervous system	AM38	10.5
Central nervous system	BECKER	10.4
Central nervous system	CAS1	10.1
Central nervous system	CCFSTTG1	10.3
Central nervous system	D283MED	9.8
Central nervous system	D341MED	9.2
Central nervous system	DAOY	10.4
Central nervous system	DBTRG05MG	9.7
Central nervous system	DKMG	8.6
Central nervous system	GAMG	10.9
Central nervous system	GB1	11.5
Central nervous system	GI1	10.3
Central nervous system	GMS10	10.4
Central nervous system	GOS3	8.1
Central nervous system	H4	10.1
Central nervous system	HS683	10.5
Central nervous system	KALS1	10.9
Central nervous system	KG1C	10.2
Central nervous system	KNS42	10.1
Central nervous system	KNS60	10.2
Central nervous system	KNS81	9.9
Central nervous system	KS1	9.8
Central nervous system	LN18	10.8
Central nervous system	LN229	10.1
Central nervous system	M059K	9.8
Central nervous system	MOGGCCM	10.3
Central nervous system	MOGGUVW	11.4
Central nervous system	NMCG1	10.4
Central nervous system	ONS76	10.7
Central nervous system	SF126	11
Central nervous system	SF295	10.5
Central nervous system	SNB19	10.8
Central nervous system	SNU1105	10.1
Central nervous system	SNU201	9.3
Central nervous system	SNU466	9.4
Central nervous system	SNU489	9.7
Central nervous system	SNU626	9
Central nervous system	SNU738	10.5
Central nervous system	SW1088	10.6
Central nervous system	SW1783	10.7
Central nervous system	T98G	10.2
Central nervous system	TM31	11
Central nervous system	U118MG	10.6
Central nervous system	U138MG	9.7
Central nervous system	U251MG	10.7
Central nervous system	U87MG	9.5
Central nervous system	YH13	9.5
Central nervous system	YKG1	11
Endometrium	AN3CA	10.6
Endometrium	COLO684	10.7
Endometrium	EFE184	9.8
Endometrium	EN	10.7
Endometrium	ESS1	10.4
Endometrium	HEC108	10.5
Endometrium	HEC151	10.9
Endometrium	HEC1A	11.1
Endometrium	HEC1B	11
Endometrium	HEC251	10.3
Endometrium	HEC265	10.6
Endometrium	HEC50B	10.9
Endometrium	HEC59	10.6
Endometrium	HEC6	10.9
Endometrium	ISHIKAWAHERAKLIO02ER	9.8
Endometrium	JHUEM1	10
Endometrium	JHUEM2	10.9
Endometrium	JHUEM3	10.5
Endometrium	KLE	10.5
Endometrium	MFE280	10.8
Endometrium	MFE296	10.9
Endometrium	MFE319	9.7
Endometrium	RL952	10.5
Endometrium	SNGM	9.5
Endometrium	SNU1077	10.8
Endometrium	SNU685	10.3
Endometrium	TEN	11.1
Haematopoietic and lymphoid	697	10.7
Haematopoietic and lymphoid	A3KAW	11
Haematopoietic and lymphoid	A4FUK	10.9
Haematopoietic and lymphoid	ALLSIL	11.8
Haematopoietic and lymphoid	AML193	10.6
Haematopoietic and lymphoid	AMO1	10.5
Haematopoietic and lymphoid	BCP1	10.9
Haematopoietic and lymphoid	BDCM	10.6
Haematopoietic and lymphoid	BL41	11.2
Haematopoietic and lymphoid	BL70	11.5
Haematopoietic and lymphoid	BV173	10.4
Haematopoietic and lymphoid	CA46	10.4
Haematopoietic and lymphoid	CI1	11.5
Haematopoietic and lymphoid	CMK115	11.1
Haematopoietic and lymphoid	CMK86	10.6
Haematopoietic and lymphoid	CMK	10.5
Haematopoietic and lymphoid	CMLT1	11.3
Haematopoietic and lymphoid	COLO775	10
Haematopoietic and lymphoid	DAUDI	11.2
Haematopoietic and lymphoid	DB	11.8
Haematopoietic and lymphoid	DEL	9.4
Haematopoietic and lymphoid	DND41	11.1
Haematopoietic and lymphoid	DOHH2	12
Haematopoietic and lymphoid	EB1	10.7
Haematopoietic and lymphoid	EB2	10.8
Haematopoietic and lymphoid	EHEB	10.4
Haematopoietic and lymphoid	EJM	9.4
Haematopoietic and lymphoid	EM2	10.9
Haematopoietic and lymphoid	EOL1	10.8
Haematopoietic and lymphoid	F36P	10.2
Haematopoietic and lymphoid	GA10	11.2
Haematopoietic and lymphoid	GDM1	10.6
Haematopoietic and lymphoid	GRANTA519	10.1
Haematopoietic and lymphoid	HDLM2	10.6
Haematopoietic and lymphoid	HDMYZ	10.2
Haematopoietic and lymphoid	HEL9217	10.7
Haematopoietic and lymphoid	HEL	10.6
Haematopoietic and lymphoid	HH	10.8
Haematopoietic and lymphoid	HL60	10.7
Haematopoietic and lymphoid	HPBALL	11.6
Haematopoietic and lymphoid	HS604T	9.9
Haematopoietic and lymphoid	HS611T	11.8
Haematopoietic and lymphoid	HS616T	9.2
Haematopoietic and lymphoid	HS751T	8.5
Haematopoietic and lymphoid	HT	12.5
Haematopoietic and lymphoid	HTK	10
Haematopoietic and lymphoid	HUNS1	10.4
Haematopoietic and lymphoid	HUT102	10.9
Haematopoietic and lymphoid	HUT78	11.6
Haematopoietic and lymphoid	JEKO1	10.4
Haematopoietic and lymphoid	JK1	10.3
Haematopoietic and lymphoid	JM1	11
Haematopoietic and lymphoid	JURKAT	11.2
Haematopoietic and lymphoid	JURLMK1	11.2
Haematopoietic and lymphoid	JVM2	9.1
Haematopoietic and lymphoid	JVM3	10.1
Haematopoietic and lymphoid	K562	10.7
Haematopoietic and lymphoid	KARPAS299	9.3
Haematopoietic and lymphoid	KARPAS422	11.4
Haematopoietic and lymphoid	KARPAS620	10.3
Haematopoietic and lymphoid	KASUMI1	10.1
Haematopoietic and lymphoid	KASUMI2	10.3
Haematopoietic and lymphoid	KASUMI6	9.7
Haematopoietic and lymphoid	KCL22	10.3
Haematopoietic and lymphoid	KE37	11.1
Haematopoietic and lymphoid	KE97	11.1
Haematopoietic and lymphoid	KG1	11.3
Haematopoietic and lymphoid	KHM1B	9.7
Haematopoietic and lymphoid	KIJK	10.5
Haematopoietic and lymphoid	KMH2	10.3
Haematopoietic and lymphoid	KMM1	10.2
Haematopoietic and lymphoid	KMS11	10.6
Haematopoietic and lymphoid	KMS12BM	10.2
Haematopoietic and lymphoid	KMS18	10.8
Haematopoietic and lymphoid	KMS20	10
Haematopoietic and lymphoid	KMS21BM	10.1
Haematopoietic and lymphoid	KMS26	9.5
Haematopoietic and lymphoid	KMS27	9.6
Haematopoietic and lymphoid	KMS28BM	9.7
Haematopoietic and lymphoid	KMS34	10
Haematopoietic and lymphoid	KO52	11.4
Haematopoietic and lymphoid	KOPN8	11.2
Haematopoietic and lymphoid	KU812	10.2
Haematopoietic and lymphoid	KYO1	10.3
Haematopoietic and lymphoid	L1236	11.1
Haematopoietic and lymphoid	L363	10.3
Haematopoietic and lymphoid	L428	11.1
Haematopoietic and lymphoid	L540	10.3
Haematopoietic and lymphoid	LAMA84	10
Haematopoietic and lymphoid	LOUCY	11.2
Haematopoietic and lymphoid	LP1	8.9
Haematopoietic and lymphoid	M07E	9.8
Haematopoietic and lymphoid	MC116	11.3
Haematopoietic and lymphoid	ME1	10.9
Haematopoietic and lymphoid	MEC1	11
Haematopoietic and lymphoid	MEC2	11.1
Haematopoietic and lymphoid	MEG01	10
Haematopoietic and lymphoid	MHHCALL2	10.7
Haematopoietic and lymphoid	MHHCALL3	10.7
Haematopoietic and lymphoid	MHHCALL4	10.5
Haematopoietic and lymphoid	MINO	11.2
Haematopoietic and lymphoid	MJ	10.9
Haematopoietic and lymphoid	MM1S	10.1
Haematopoietic and lymphoid	MOLM13	10.8
Haematopoietic and lymphoid	MOLM16	10.5
Haematopoietic and lymphoid	MOLM6	11.2
Haematopoietic and lymphoid	MOLP2	8.8
Haematopoietic and lymphoid	MOLP8	10.4
Haematopoietic and lymphoid	MOLT13	11.5
Haematopoietic and lymphoid	MOLT16	11.1
Haematopoietic and lymphoid	MOLT4	11.1
Haematopoietic and lymphoid	MONOMAC1	10.6
Haematopoietic and lymphoid	MONOMAC6	10.9
Haematopoietic and lymphoid	MOTN1	11.2
Haematopoietic and lymphoid	MUTZ5	10.6
Haematopoietic and lymphoid	MV411	11.2
Haematopoietic and lymphoid	NALM19	11.3
Haematopoietic and lymphoid	NALM1	10.5
Haematopoietic and lymphoid	NALM6	11.1
Haematopoietic and lymphoid	NAMALWA	11
Haematopoietic and lymphoid	NB4	10.6
Haematopoietic and lymphoid	NCIH929	9.9
Haematopoietic and lymphoid	NCO2	10.4
Haematopoietic and lymphoid	NOMO1	10.8
Haematopoietic and lymphoid	NUDHL1	11.4
Haematopoietic and lymphoid	NUDUL1	10.6
Haematopoietic and lymphoid	OCIAML2	10.6
Haematopoietic and lymphoid	OCIAML3	10.6
Haematopoietic and lymphoid	OCIAML5	10.1
Haematopoietic and lymphoid	OCILY10	11.3
Haematopoietic and lymphoid	OCILY19	10.4
Haematopoietic and lymphoid	OCILY3	10.1
Haematopoietic and lymphoid	OCIM1	10.3
Haematopoietic and lymphoid	OPM2	9.9
Haematopoietic and lymphoid	P12ICHIKAWA	11.9
Haematopoietic and lymphoid	P31FUJ	10
Haematopoietic and lymphoid	P3HR1	11.6
Haematopoietic and lymphoid	PCM6	9.6
Haematopoietic and lymphoid	PEER	11.3
Haematopoietic and lymphoid	PF382	10.9
Haematopoietic and lymphoid	PFEIFFER	12
Haematopoietic and lymphoid	PL21	10.7
Haematopoietic and lymphoid	RAJI	11.2
Haematopoietic and lymphoid	RCHACV	10.8
Haematopoietic and lymphoid	REC1	10.8
Haematopoietic and lymphoid	REH	10.8
Haematopoietic and lymphoid	RI1	11.3
Haematopoietic and lymphoid	RL	11.7
Haematopoietic and lymphoid	RPMI8226	10.4
Haematopoietic and lymphoid	RPMI8402	11.2
Haematopoietic and lymphoid	RS411	10.7
Haematopoietic and lymphoid	SEM	11.1
Haematopoietic and lymphoid	SET2	9.5
Haematopoietic and lymphoid	SIGM5	11.2
Haematopoietic and lymphoid	SKM1	10.9
Haematopoietic and lymphoid	SKMM2	10.2
Haematopoietic and lymphoid	SR786	10.1
Haematopoietic and lymphoid	ST486	10.7
Haematopoietic and lymphoid	SUDHL10	11.7
Haematopoietic and lymphoid	SUDHL1	8.6
Haematopoietic and lymphoid	SUDHL4	11.8
Haematopoietic and lymphoid	SUDHL5	11.8
Haematopoietic and lymphoid	SUDHL6	12.1
Haematopoietic and lymphoid	SUDHL8	10.6
Haematopoietic and lymphoid	SUPB15	10.9
Haematopoietic and lymphoid	SUPHD1	9.4
Haematopoietic and lymphoid	SUPM2	9.3
Haematopoietic and lymphoid	SUPT11	12
Haematopoietic and lymphoid	SUPT1	11.6
Haematopoietic and lymphoid	TALL1	11.1
Haematopoietic and lymphoid	TF1	10.5
Haematopoietic and lymphoid	THP1	10.9
Haematopoietic and lymphoid	TO175T	9.2
Haematopoietic and lymphoid	TOLEDO	10.7
Haematopoietic and lymphoid	U266B1	9.5
Haematopoietic and lymphoid	U937	10.2
Haematopoietic and lymphoid	UT7	10.4
Haematopoietic and lymphoid	WSUDLCL2	11.9
Kidney	769P	10.8
Kidney	786O	10.6
Kidney	A498	9.6
Kidney	A704	8.2
Kidney	ACHN	9.6
Kidney	BFTC909	9.2
Kidney	CAKI1	10.1
Kidney	CAKI2	9.9
Kidney	CAL54	9.8
Kidney	KMRC1	10.4
Kidney	KMRC20	10
Kidney	KMRC2	10.7
Kidney	KMRC3	8.5
Kidney	OSRC2	10.6
Kidney	RCC10RGB	9.7
Kidney	SNU1272	10.3
Kidney	SNU349	9
Kidney	TUHR10TKB	10.7
Kidney	TUHR14TKB	9.1
Kidney	TUHR4TKB	10.8
Kidney	VMRCRCW	9.6
Kidney	VMRCRCZ	8.8
Large intestine	C2BBE1	10.2
Large intestine	CCK81	11.5
Large intestine	CL11	10.3
Large intestine	CL14	10.3
Large intestine	CL34	11.4
Large intestine	CL40	10.8
Large intestine	COLO205	11.6
Large intestine	COLO320	10.4
Large intestine	COLO678	9.9
Large intestine	CW2	11.2
Large intestine	DLD1	10.3
Large intestine	GP2D	10.2
Large intestine	HCC56	10.7
Large intestine	HCT116	11.1
Large intestine	HCT15	10.9
Large intestine	HS675T	9.8
Large intestine	HS698T	9.1
Large intestine	HT115	10.6
Large intestine	HT29	11.4
Large intestine	HT55	9.5
Large intestine	KM12	11.4
Large intestine	LOVO	11.2
Large intestine	LS1034	10.4
Large intestine	LS123	10
Large intestine	LS180	11.2
Large intestine	LS411N	12
Large intestine	LS513	10.1
Large intestine	MDST8	9
Large intestine	NCIH508	9.6
Large intestine	NCIH716	11.1
Large intestine	NCIH747	10.5
Large intestine	OUMS23	10
Large intestine	RCM1	9.8
Large intestine	RKO	10
Large intestine	SKCO1	10.9
Large intestine	SNU1040	10.9
Large intestine	SNU1197	10.4
Large intestine	SNU175	10.6
Large intestine	SNU283	11.3
Large intestine	SNU407	10.2
Large intestine	SNU503	10.6
Large intestine	SNU61	10.7
Large intestine	SNU81	11.3
Large intestine	SNUC1	10.7
Large intestine	SNUC2A	10.7
Large intestine	SNUC4	11.2
Large intestine	SNUC5	10.7
Large intestine	SW1116	10.1
Large intestine	SW1417	10.4
Large intestine	SW1463	11.2
Large intestine	SW403	10.7
Large intestine	SW480	9.8
Large intestine	SW48	10
Large intestine	SW620	11.3
Large intestine	SW837	10.6
Large intestine	SW948	11.2
Large intestine	T84	11.2
Liver	ALEXANDERCELLS	10.7
Liver	C3A	10.1
Liver	HEP3B217	10.2
Liver	HEPG2	9.9
Liver	HLE	10.5
Liver	HLF	10.9
Liver	HUH1	10.1
Liver	HUH6	10.8
Liver	HUH7	10.7
Liver	JHH1	10
Liver	JHH2	11.1
Liver	JHH4	11.1
Liver	JHH5	10.3
Liver	JHH6	9.6
Liver	JHH7	10.6
Liver	LI7	10.6
Liver	PLCPRF5	10.5
Liver	SKHEP1	9.8
Liver	SNU182	10.1
Liver	SNU387	10.2
Liver	SNU398	9.5
Liver	SNU423	10.3
Liver	SNU449	9.8
Liver	SNU475	10.6
Liver	SNU761	10.1
Liver	SNU878	10.4
Liver	SNU886	11
Lung	A549	9.7
Lung	ABC1	10.4
Lung	BEN	11.2
Lung	CAL12T	9.7
Lung	CALU1	10.3
Lung	CALU3	10.7
Lung	CALU6	10.4
Lung	CHAGOK1	9.8
Lung	COLO668	11.2
Lung	COLO699	11.2
Lung	CORL105	9
Lung	CORL23	10.2
Lung	CORL24	11.7
Lung	CORL279	10.5
Lung	CORL311	9.7
Lung	CORL47	9.4
Lung	CORL51	9.9
Lung	CORL88	10.6
Lung	CORL95	9.8
Lung	CPCN	10
Lung	DMS114	10.5
Lung	DMS153	12
Lung	DMS273	9.5
Lung	DMS454	9.6
Lung	DMS53	10.8
Lung	DMS79	11
Lung	DV90	10.6
Lung	EBC1	11.3
Lung	EPLC272H	10
Lung	HARA	10.2
Lung	HCC1171	9.9
Lung	HCC1195	11.4
Lung	HCC15	11
Lung	HCC2279	10.1
Lung	HCC2935	9.6
Lung	HCC33	10.3
Lung	HCC366	10.3
Lung	HCC4006	10.5
Lung	HCC44	10
Lung	HCC78	9.9
Lung	HCC827	10.2
Lung	HCC95	10.3
Lung	HLC1	10.3
Lung	HLFA	10
Lung	HS229T	9.7
Lung	HS618T	9.6
Lung	IALM	10.4
Lung	KNS62	10.3
Lung	LC1F	10.6
Lung	LC1SQSF	9.8
Lung	LCLC103H	10.2
Lung	LCLC97TM1	10
Lung	LK2	10.1
Lung	LOUNH91	10.2
Lung	LU65	10.8
Lung	LU99	10.5
Lung	LUDLU1	10.2
Lung	LXF289	9.6
Lung	MORCPR	10.4
Lung	NCIH1048	11
Lung	NCIH1092	9
Lung	NCIH1105	10.1
Lung	NCIH1155	10.7
Lung	NCIH1184	9.4
Lung	NCIH1299	10.8
Lung	NCIH1339	9.7
Lung	NCIH1341	9.8
Lung	NCIH1355	10
Lung	NCIH1373	10
Lung	NCIH1385	10.1
Lung	NCIH1395	8.9
Lung	NCIH1435	10.9
Lung	NCIH1436	9.8
Lung	NCIH1437	9.7
Lung	NCIH146	10
Lung	NCIH1563	9.4
Lung	NCIH1568	10
Lung	NCIH1573	9.9
Lung	NCIH1581	11.4
Lung	NCIH1618	10.3
Lung	NCIH1623	10.4
Lung	NCIH1648	10.7
Lung	NCIH1650	10.5
Lung	NCIH1651	9.5
Lung	NCIH1666	10.3
Lung	NCIH1693	10.4
Lung	NCIH1694	9.6
Lung	NCIH1703	10.7
Lung	NCIH1734	10.4
Lung	NCIH1755	10.5
Lung	NCIH1781	10.2
Lung	NCIH1792	10.1
Lung	NCIH1793	9.9
Lung	NCIH1836	10.6
Lung	NCIH1838	9.1
Lung	NCIH1869	9.8
Lung	NCIH1876	9.3
Lung	NCIH1915	9.7
Lung	NCIH1930	9.7
Lung	NCIH1944	9.8
Lung	NCIH1963	10.1
Lung	NCIH196	9.7
Lung	NCIH1975	10.4
Lung	NCIH2009	11.1
Lung	NCIH2023	10.7
Lung	NCIH2029	9.6
Lung	NCIH2030	10.2
Lung	NCIH2066	10.7
Lung	NCIH2081	10.1
Lung	NCIH2085	9.9
Lung	NCIH2087	11.1
Lung	NCIH209	11.3
Lung	NCIH2106	10.3
Lung	NCIH2110	9.6
Lung	NCIH211	10.5
Lung	NCIH2122	9.9
Lung	NCIH2126	9.2
Lung	NCIH2141	10
Lung	NCIH2170	10.8
Lung	NCIH2171	10
Lung	NCIH2172	9.2
Lung	NCIH2196	10.8
Lung	NCIH2227	10.2
Lung	NCIH2228	9.5
Lung	NCIH226	10
Lung	NCIH2286	9.6
Lung	NCIH2291	10.4
Lung	NCIH2342	10.5
Lung	NCIH2347	10.1
Lung	NCIH23	10.6
Lung	NCIH2405	9.7
Lung	NCIH2444	10.8
Lung	NCIH292	10.4
Lung	NCIH322	10.7
Lung	NCIH3255	10.2
Lung	NCIH358	10.6
Lung	NCIH441	10.6
Lung	NCIH446	9.9
Lung	NCIH460	9.6
Lung	NCIH510	10.2
Lung	NCIH520	10.1
Lung	NCIH522	10.6
Lung	NCIH524	10
Lung	NCIH526	10.7
Lung	NCIH596	9.1
Lung	NCIH647	10.8
Lung	NCIH650	9.8
Lung	NCIH661	11
Lung	NCIH69	9.5
Lung	NCIH727	11.3
Lung	NCIH810	11.1
Lung	NCIH82	10.5
Lung	NCIH838	10.4
Lung	NCIH841	10.9
Lung	NCIH854	11.8
Lung	NCIH889	9.2
Lung	PC14	10.7
Lung	RERFLCAD1	10.7
Lung	RERFLCAD2	9.7
Lung	RERFLCAI	10.3
Lung	RERFLCKJ	9.1
Lung	RERFLCMS	10.7
Lung	RERFLCSQ1	10.6
Lung	SBC5	10.9
Lung	SCLC21H	9.7
Lung	SHP77	10.6
Lung	SKLU1	9.6
Lung	SKMES1	10.2
Lung	SQ1	10.1
Lung	SW1271	10.2
Lung	SW1573	10.4
Lung	SW900	9.9
Lung	VMRCLCD	11.8
Lung	VMRCLCP	10.1
Oesophagus	COLO680N	10.6
Oesophagus	ECGI10	8.6
Oesophagus	KYSE140	10.8
Oesophagus	KYSE150	10.7
Oesophagus	KYSE180	10
Oesophagus	KYSE270	10
Oesophagus	KYSE30	11
Oesophagus	KYSE410	10.9
Oesophagus	KYSE450	10.1
Oesophagus	KYSE510	10.7
Oesophagus	KYSE520	10.6
Oesophagus	KYSE70	10.3
Oesophagus	OE19	10.6
Oesophagus	OE33	10
Oesophagus	TE10	10.8
Oesophagus	TE11	10.9
Oesophagus	TE14	10.5
Oesophagus	TE15	10.9
Oesophagus	TE1	10.8
Oesophagus	TE4	10.1
Oesophagus	TE5	11
Oesophagus	TE6	9.6
Oesophagus	TE8	11.1
Oesophagus	TE9	10.8
Oesophagus	TT	10.5
Ovary	59M	10.6
Ovary	A2780	11.8
Ovary	CAOV3	10
Ovary	CAOV4	10.1
Ovary	COLO704	10.9
Ovary	COV318	10.4
Ovary	COV362	9.1
Ovary	COV434	10
Ovary	COV504	10.3
Ovary	COV644	9.3
Ovary	EFO21	9.8
Ovary	EFO27	10.4
Ovary	ES2	10.6
Ovary	FUOV1	9.3
Ovary	HEYA8	10.3
Ovary	HS571T	8.8
Ovary	IGROV1	10.7
Ovary	JHOC5	10.7
Ovary	JHOM1	9.8
Ovary	JHOM2B	11.6
Ovary	JHOS2	10.2
Ovary	JHOS4	9.7
Ovary	KURAMOCHI	11.4
Ovary	MCAS	10.2
Ovary	NIHOVCAR3	10
Ovary	OAW28	10.3
Ovary	OAW42	10.1
Ovary	OC314	10.6
Ovary	OC316	10.7
Ovary	ONCODG1	10.5
Ovary	OV56	9.3
Ovary	OV7	9.6
Ovary	OV90	10.5
Ovary	OVCAR4	10.8
Ovary	OVCAR8	9.7
Ovary	OVISE	10.6
Ovary	OVK18	11
Ovary	OVKATE	10.1
Ovary	OVMANA	9.8
Ovary	OVSAHO	10.2
Ovary	OVTOKO	10
Ovary	RMGI	9.4
Ovary	RMUGS	10.4
Ovary	SKOV3	10.3
Ovary	SNU119	10.5
Ovary	SNU840	9.4
Ovary	SNU8	10.5
Ovary	TOV112D	10.2
Ovary	TOV21G	10.4
Ovary	TYKNU	11.3
Pancreas	ASPC1	10.9
Pancreas	BXPC3	11.6
Pancreas	CAPAN1	10
Pancreas	CAPAN2	11
Pancreas	CFPAC1	10.7
Pancreas	DANG	11.2
Pancreas	HPAC	10.6
Pancreas	HPAFII	10.9
Pancreas	HS766T	10.7
Pancreas	HUPT3	10.3
Pancreas	HUPT4	10.9
Pancreas	KCIMOH1	11.1
Pancreas	KLM1	11.3
Pancreas	KP2	10.6
Pancreas	KP3	10.8
Pancreas	KP4	11.3
Pancreas	L33	10.4
Pancreas	MIAPACA2	11.6
Pancreas	PANC0203	10.3
Pancreas	PANC0213	9.1
Pancreas	PANC0327	9.6
Pancreas	PANC0403	10
Pancreas	PANC0504	10.4
Pancreas	PANC0813	10.7
Pancreas	PANC1005	10.1
Pancreas	PANC1	11.3
Pancreas	PATU8902	10.6
Pancreas	PATU8988S	11
Pancreas	PATU8988T	10.4
Pancreas	PK1	10.9
Pancreas	PK45H	10.4
Pancreas	PK59	10.3
Pancreas	PL45	10.1
Pancreas	PSN1	11.4
Pancreas	QGP1	10.3
Pancreas	SNU213	10.4
Pancreas	SNU324	10.1
Pancreas	SNU410	9.8
Pancreas	SU8686	10.3
Pancreas	SUIT2	10.7
Pancreas	SW1990	9.8
Pancreas	T3M4	11
Pancreas	TCCPAN2	10.4
Pancreas	YAPC	10.4
Pleura	ACCMESO1	10.3
Pleura	DM3	9.6
Pleura	ISTMES1	8.4
Pleura	ISTMES2	9.9
Pleura	JL1	8.6
Pleura	MPP89	9.6
Pleura	MSTO211H	9.7
Pleura	NCIH2052	9.6
Pleura	NCIH2452	10.8
Pleura	NCIH28	10.2
Prostate	22RV1	11.5
Prostate	DU145	10
Prostate	LNCAPCLONEFGC	11
Prostate	MDAPCA2B	10.9
Prostate	NCIH660	11.3
Prostate	PC3	10.6
Prostate	VCAP	11.1
Salivary gland	A253	9.9
Salivary gland	YD15	10.7
Skin	A101D	10.8
Skin	A2058	9.9
Skin	A375	10.8
Skin	C32	9.8
Skin	CHL1	11
Skin	CJM	10.4
Skin	COLO679	10
Skin	COLO741	9.5
Skin	COLO783	9.5
Skin	COLO792	9.6
Skin	COLO800	10.5
Skin	COLO818	10.6
Skin	COLO829	9.8
Skin	COLO849	10
Skin	G361	10.7
Skin	GRM	11.8
Skin	HMCB	11.3
Skin	HS294T	10.3
Skin	HS600T	8.8
Skin	HS688AT	9.7
Skin	HS695T	9.2
Skin	HS839T	9.2
Skin	HS852T	10.1
Skin	HS895T	9.5
Skin	HS934T	8.6
Skin	HS936T	9.5
Skin	HS939T	10.4
Skin	HS940T	9
Skin	HS944T	10.4
Skin	HT144	10.7
Skin	IGR1	9.5
Skin	IGR37	10.5
Skin	IGR39	10.4
Skin	IPC298	10.2
Skin	K029AX	10.7
Skin	LOXIMVI	10.4
Skin	MALME3M	8.9
Skin	MDAMB435S	9.3
Skin	MELHO	10.8
Skin	MELJUSO	10.2
Skin	MEWO	9.9
Skin	RPMI7951	9.7
Skin	RVH421	10
Skin	SH4	10.2
Skin	SKMEL1	9.5
Skin	SKMEL24	9.5
Skin	SKMEL28	10.6
Skin	SKMEL2	10.2
Skin	SKMEL30	11
Skin	SKMEL31	10.5
Skin	SKMEL3	10.3
Skin	SKMEL5	10.1
Skin	UACC257	10.1
Skin	UACC62	10.3
Skin	WM115	9.9
Skin	WM1799	9.5
Skin	WM2664	10.3
Skin	WM793	9.5
Skin	WM88	9.3
Skin	WM983B	10.4
Small intestine	HUTU80	10.7
Soft tissue	A204	11
Soft tissue	G401	10.6
Soft tissue	G402	10.9
Soft tissue	GCT	10.3
Soft tissue	HS729	10.3
Soft tissue	HT1080	10.5
Soft tissue	KYM1	10.9
Soft tissue	MESSA	9.3
Soft tissue	RD	11
Soft tissue	RH30	10.7
Soft tissue	RH41	10.9
Soft tissue	RKN	10.8
Soft tissue	S117	10.4
Soft tissue	SJRH30	10.5
Soft tissue	SKLMS1	10.5
Soft tissue	SKUT1	10.5
Soft tissue	TE125T	8.2
Soft tissue	TE159T	8.6
Soft tissue	TE441T	8
Soft tissue	TE617T	10.8
Stomach	2313287	11.1
Stomach	AGS	11.3
Stomach	AZ521	10.8
Stomach	ECC10	10.6
Stomach	ECC12	11.3
Stomach	FU97	10.2
Stomach	GCIY	10.2
Stomach	GSS	10.9
Stomach	GSU	10.7
Stomach	HGC27	10.3
Stomach	HS746T	10
Stomach	HUG1N	11.6
Stomach	IM95	11.1
Stomach	KATOIII	10.9
Stomach	KE39	11.4
Stomach	LMSU	10.7
Stomach	MKN1	10.5
Stomach	MKN45	12.1
Stomach	MKN74	10
Stomach	MKN7	10
Stomach	NCCSTCK140	10
Stomach	NCIN87	10
Stomach	NUGC2	10.6
Stomach	NUGC3	10.3
Stomach	NUGC4	10.8
Stomach	OCUM1	10.7
Stomach	RERFGC1B	11.2
Stomach	SH10TC	10.4
Stomach	SNU16	11.6
Stomach	SNU1	11.6
Stomach	SNU216	10.4
Stomach	SNU520	11.7
Stomach	SNU5	9.7
Stomach	SNU601	11.5
Stomach	SNU620	11.2
Stomach	SNU668	9.5
Stomach	SNU719	11.4
Stomach	TGBC11TKB	11.7
Thyroid	8305C	10.1
Thyroid	8505C	10.4
Thyroid	BCPAP	11.6
Thyroid	BHT101	10.9
Thyroid	CAL62	10.2
Thyroid	CGTHW1	10.4
Thyroid	FTC133	9.3
Thyroid	FTC238	10.6
Thyroid	ML1	10.4
Thyroid	SW579	10.1
Thyroid	TT2609C02	10.7
Thyroid	TT	8.8
Upper aerodigestive tract	BHY	9.7
Upper aerodigestive tract	BICR16	10.5
Upper aerodigestive tract	BICR18	10.4
Upper aerodigestive tract	BICR22	10.3
Upper aerodigestive tract	BICR31	9.5
Upper aerodigestive tract	BICR56	10.2
Upper aerodigestive tract	BICR6	9.9
Upper aerodigestive tract	CAL27	10.5
Upper aerodigestive tract	CAL33	10.6
Upper aerodigestive tract	DETROIT562	9.6
Upper aerodigestive tract	FADU	10.6
Upper aerodigestive tract	HS840T	9.5
Upper aerodigestive tract	HSC2	10.5
Upper aerodigestive tract	HSC3	10.8
Upper aerodigestive tract	HSC4	9
Upper aerodigestive tract	PECAPJ15	10.1
Upper aerodigestive tract	PECAPJ34CLONEC12	10.6
Upper aerodigestive tract	PECAPJ41CLONED2	9.7
Upper aerodigestive tract	PECAPJ49	10.8
Upper aerodigestive tract	SCC15	10.3
Upper aerodigestive tract	SCC25	10.7
Upper aerodigestive tract	SCC4	10.3
Upper aerodigestive tract	SCC9	9.7
Upper aerodigestive tract	SNU1076	10.5
Upper aerodigestive tract	SNU1214	10.8
Upper aerodigestive tract	SNU46	9.5
Upper aerodigestive tract	SNU899	10.4
Upper aerodigestive tract	YD10B	10.4
Upper aerodigestive tract	YD38	10.7
Upper aerodigestive tract	YD8	9.3
Urinary tract	5637	10.5
Urinary tract	639V	10.4
Urinary tract	647V	10.3
Urinary tract	BC3C	10
Urinary tract	BFTC905	9.9
Urinary tract	CAL29	11
Urinary tract	HS172T	9.8
Urinary tract	HT1197	9.5
Urinary tract	HT1376	10
Urinary tract	J82	10.2
Urinary tract	JMSU1	10.8
Urinary tract	KMBC2	9.8
Urinary tract	KU1919	10.3
Urinary tract	RT11284	10.5
Urinary tract	RT112	10.8
Urinary tract	RT4	11
Urinary tract	SCABER	10.9
Urinary tract	SW1710	10.7
Urinary tract	SW780	10.8
Urinary tract	T24	10.5
Urinary tract	TCCSUP	9.8
Urinary tract	UMUC1	10.1
Urinary tract	UMUC3	10.5
Urinary tract	VMCUB1	10.6

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	32.9
Adrenal gland	53
Appendix	104.7
Bone marrow	36.6
Breast	70.3
Cerebral cortex	19.4
Cervix, uterine	84.9
Colon	119.8
Duodenum	76.5
Endometrium	79.4
Epididymis	61.4
Esophagus	74.9
Fallopian tube	91.4
Gallbladder	87.1
Heart muscle	19.3
Kidney	48.4
Liver	21.5
Lung	61.6
Lymph node	140.7
Ovary	80.4
Pancreas	7.5
Parathyroid gland	85.4
Placenta	75.3
Prostate	90.7
Rectum	120.9
Salivary gland	22.9
Seminal vesicle	79.6
Skeletal muscle	5.3
Skin	45
Small intestine	91.3
Smooth muscle	68.5
Spleen	85.2
Stomach	80
Testis	68.2
Thyroid gland	130.5
Tonsil	116.5
Urinary bladder	78.4

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
20049841	Overexpression	Ovarian Carcinoma	The results indicated that the immunohistochemical expression of nuclear HDAC1, HDAC2 and HDAC3 proteins increased stepwise in benign, borderline and malignant tumors.
21143702	Overexpression	Glioma	Expression of HDAC1 and HDAC2 increased during tumor recurrence and malignant tumor progression, respectively, whereas expression of the remaining antigens did not seem to depend on tumor grade and was comparable to expression levels found in non-neoplastic brain tissues.
22270866	Overexpression	Colorectal Adenocarcinoma	The immunohistochemical staining of HDACs, including HDAC1, HDAC2, HDAC3, and HDAC4, was significantly increased in colorectal adenocarcinoma specimens compared to healthy control tissues.
22455563	Overexpression	Breast Carcinoma	Increased expression of HDAC1 was correlated with histological grade (P < 0.001), age (P = 0.004), clinical stage (P = 0.007) and lymph node metastasis (P = 0.001).
23110995	Overexpression	Non-Small Cell Lung Cancer	Expression of HDAC1 and that of HDAC2 were correlated, and significantly higher in NSCLC tissues than in normal lung tissues (P<0.05).
23420051	Overexpression	Ovarian Carcinoma	Furthermore, the expression of DNMT1, DNMT3b, HDAC1 and HDAC2 was significantly higher in stage III/IV compared with stage I/II ovarian carcinomas.
23627572	Overexpression	Breast Carcinoma	In this cohort, we found a differential positive expression of HDAC1, HDAC2 and HDAC3. HDAC2 and HDAC3 expression was significantly higher in less differentiated tumors: HDAC2 (n=207), p<0.001 and HDAC3 (n=220), p<0.001 and correlated with negative hormone receptor status: HDAC2 (n=206), p=0.02 and HDAC3 (n=219), p=0.04.
23724067	Overexpression	Colorectal Carcinoma	We found HDAC1, HDAC2, HDAC3, HDAC5, and HDAC7 all to be up-regulated in the field of human CRC.
23948281	Overexpression	Acute Lymphoblastic Leukemia	HDAC1, HDAC2 and HDAC8 showed significantly higher expressions in ALL samples. Correlation analysis of HDAC expression with clinicopathological parameters revealed that high HDAC1, HDAC2, HDAC4 and HDAC11 levels were significantly associated with unfavorable prognostic factors.
27507654	Overexpression	Hepatocellular Carcinoma	The results showed that the expressions of amyloid precursor protein and histone deacetylase 1 were significantly higher in hepatocellular carcinoma tissues than that in adjacent tissues (P < .05), however, there was no statistical difference between amyloid precursor protein and histone deacetylase 1 with tumor stages.
27152243	Overexpression	Colorectal Carcinoma	Furthermore, also HDAC1 (62%), HDAC2 (100%) and HDAC3 (72%) expression was frequent, revealing four CRC types: cases expressing 1) HDAC1, HDAC2 and HDAC3 (49%), 2) HDAC2 and HDAC3 (30%), 3) HDAC1 and HDAC2 (10.5%) and 4) exclusively HDAC2 (10.5%). Correlation to clinico-pathological parameters (pT, pN, G, MSI status) revealed that heterogeneous HDAC1 expression correlated with lymph node status (p=0.012).
26588579	Overexpression	Laryngeal Squamous Cell Carcinoma	The expression of HDAC1 was up-regulated and significantly associated with T classification, lymph node metastases, tumor location and clinical stage.
26423403	Overexpression	Colorectal Carcinoma	PAK1, NEK6, AURKA, AURKB, HDAC1, and HDAC7 were significantly more overexpressed in CRC subjects compared to the controls (p<0.05).
25794974	Overexpression	Prostate Carcinoma	High HDAC1 expression was associated with high Gleason grade (p<0.0001), advanced pathological tumor stage (p<0.0001), positive nodal status (p=0.0010), elevated preoperative PSA-level (p=0.0127), early PSA recurrence (p<0.0001) and increased cell proliferation (p<0.0001).
25792651	Overexpression	Hepatocellular Carcinoma	Histone deacetylase 1 and histone 3 were more strongly detected in hepatocellular carcinoma tissue and fibrosarcoma cells than in liver tissues and fibroblast cells, respectively. Histone deacetylase 1 overexpression and hypoacetylation of histone 3 might play critical roles in the modulation of histone 3 in human hepatocellular carcinoma
25341045	Overexpression	Acute Myeloid Leukemia	Here, we found that HDAC1 expression was negatively correlated with that of Krüppel-like factor 4 (Klf4) and that AML patients with lower HDAC1 level had better prognosis.
24762689	Overexpression	Non-Small Cell Lung Cancer	The protein expressions of HDAC1 and DNMT1 in patients with lung cancer (145 ± 53, 50 ± 11) were higher than those in control group (78 ± 56, 27 ± 6).
24668547	Underexpression	Gastric Carcinoma	Our results demonstrated downregulation of HDAC1, PCAF, and CDKN1A in gastric tumors compared with adjacent nontumors (P < 0.05).
25548579	Underexpression	Breast Carcinoma	Although the expression of HDACs did not exhibit prognostic significance in the entire cohort, high expression of HDAC1 and HDAC6 was associated with improved overall survival (OS) in patients with ER-positive tumors (p=0.017 and p=0.029, respectively), and high expression of HDAC2 was correlated with improved OS in ER-negative tumors (p=0.048) on univariate analysis.
23110022	Underexpression	Breast Carcinoma	HDAC1 expression was significantly reduced in proportion to higher histologic grade, higher nuclear pleomorphism score, and higher mitotic counts, and with lower estrogen receptor expression.
25791281	Overexpression	Glioma	Among all patients studied, the expression of HDAC1 and HDAC3 was inversely correlated with survival, whereas the expression of HDAC4, HDAC5, HDAC6, HDAC11 and SIRT1 was significantly and positively correlated with survival time of patients with gliomas.
22037263	Underexpression	Mesenchymal Sarcoma	HDAC1, in contrast, displayed lower expression in translocation-associated sarcomas than in other mesenchymal tumors or in normal tissues.
21982637	Overexpression	Intrahepatic Cholangiocarcinoma	HDAC1 expression correlated significantly with higher stage carcinoma, lymph node metastasis, and vascular invasion.
21725604	Overexpression	Gastric Carcinoma	One of the genes abundantly expressed in tumor tissue on the differential mRNA displays was identified as histone deacetylase 1 (HDAC). HDAC was overexpressed in the tumor tissue in 77% of the cases as determined by quantitative reverse transcription-PCR.
21617866	Overexpression	Colon Carcinoma	Regarding the clinicopathological factors, the depth of tumor invasion and stage correlated significantly with HDAC1 expression (p<0.05).
21466904	Overexpression	Non-Small Cell Lung Cancer	We found that the 5-year disease-free survival rate among patients strongly expressing HDAC1 was significantly poorer than among those expressing lower levels (P=0.005 by log-rank test).
21438903	Overexpression	Prostate Carcinoma	Strong HDAC1 expression was correlated with high Gleason score (P = 0.025) and high pT stage (P = 0.012). Patients with strong HDAC1 expression had higher biochemical recurrence rates (P = 0.0010). These results indicate that overexpression of HDAC1 contributes to progression and poor prognosis in prostate cancer.
21301206	Overexpression	Pancreatic Carcinoma	In human pancreatic adenocarcinoma tissues and cell lines, HDAC1 was expressed at variably elevated levels.
20467347	Overexpression	Pancreatic Ductal Adenocarcinoma	Histone deacetylase 1 mRNA in pancreatic cancer tissues were significantly higher than in paracancerous tissues (P < 0.05). Immunohistochemistry showed that the indices of HDAC1 in pancreatic cancer tissues and paracancerous tissues were 56.4% (SD, 23.1%) and 6.7% (SD, 5.0%), respectively (P < 0.001).
26352599	Overexpression	Hepatocellular Carcinoma	We found that HDAC1 and HDAC2 were upregulated in the majority of HCC tissues.
28502558	Overexpression	Gastric Carcinoma	The present study detected metastasis-associated protein 2 (MTA2) and Histone deacetylases 1 (HDAC1) proteins that were overexpressed in gastric cancer tissues compared with that in adjacent gastric tissue.
28429280	Overexpression	Medulloblastoma	We found that in HDAC1 and DNMT1 overexpressing medulloblastoma-derived cells, cell death was induced under various epigenetic drug conditions tested.
28424407	Overexpression	Colorectal Carcinoma; Gastric Carcinoma	We found that the expression level of HDAC1 in gastrointestinal malignancies, especially in colorectal cancer (OR = 10.84, 95% CI = 5.33-22.07, P< 0.00001), was higher than that in noncancerous tissue, and HDAC1 expression was closely associated with some clinical features of gastrointestinal cancer patients, such as tumor stage (OR = 1.62, 95% CI = 1.28-2.05, P < 0.0001) and tumor grade (OR = 1.75, 95% CI = 1.03-2.95, P = 0.04). In addition, we also found that patients with low HDAC1 expression showed better overall survival than those with high HDAC1 expression in gastrointestinal malignancy, especially in gastric cancer (HR = 1.88, 95% CI = 1.14-3.12, P = 0.01).
28262837	Overexpression	Hepatocellular Carcinoma	Low expression of FBP1 correlated with high levels of histone deacetylase 1 (HDAC1) and HDAC2 proteins in HCC patient tissues.
28260932	Overexpression	Chronic Lymphocytic Leukemia	The level of HDAC1 and HDAC7 mRNA expression was significantly increased (P=0.02 and P=0.008, respectively) and HDAC2 and P300 mRNA expression was reduced in patients with CLL (P=0.002 and P=0.001, respectively).

Summary
Symbol	HDAC1
Name	histone deacetylase 1
Aliases	GON-10; RPD3L1; reduced potassium dependency, yeast homolog-like 1
Location	1p35.2-p35.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.383	1.4e-15	19.1	64.6	16.3	Neutral
BRCA	Breast invasive carcinoma	1075	0.478	1.68e-62	33.2	56.5	10.3	Neutral
CESC	Cervical and endocervical cancers	292	0.511	8.1e-21	6.8	64.4	28.8	Neutral
COAD	Colon adenocarcinoma	449	0.556	8.82e-38	31	65.7	3.3	Neutral
ESCA	Esophageal carcinoma	183	0.515	8.33e-14	33.9	50.8	15.3	Loss
GBM	Glioblastoma multiforme	147	0.48	7.37e-10	7.5	73.5	19	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.43	1.33e-24	15.4	72.2	12.5	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.452	8.41e-28	16.8	81.5	1.7	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.389	7.27e-12	16.3	83.3	0.3	Neutral
LAML	Acute Myeloid Leukemia	166	0.353	2.99e-06	0	97.6	2.4	Neutral
LGG	Brain Lower Grade Glioma	513	0.792	1.21e-111	36.3	60.8	2.9	Loss
LIHC	Liver hepatocellular carcinoma	364	0.412	2.39e-16	34.9	58.8	6.3	Loss
LUAD	Lung adenocarcinoma	512	0.391	4.25e-20	20.9	55.3	23.8	Neutral
LUSC	Lung squamous cell carcinoma	498	0.467	2.32e-28	40	48	12	Loss
OV	Ovarian serous cystadenocarcinoma	300	0.615	1.17e-32	24.7	41	34.3	Gain
PAAD	Pancreatic adenocarcinoma	177	0.303	4.1e-05	25.4	68.4	6.2	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.767	1.16e-32	61.7	37	1.2	Loss
PRAD	Prostate adenocarcinoma	491	0.162	0.000309	7.7	90.6	1.6	Neutral
READ	Rectum adenocarcinoma	164	0.727	3.07e-28	37.8	57.9	4.3	Loss
SARC	Sarcoma	255	0.101	0.108	13.7	56.1	30.2	Neutral
SKCM	Skin Cutaneous Melanoma	367	0.552	1.05e-30	16.9	61	22.1	Neutral
STAD	Stomach adenocarcinoma	413	0.386	3.94e-16	21.5	68.3	10.2	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.601	4.53e-16	16	62.7	21.3	Neutral
THCA	Thyroid carcinoma	497	0.079	0.0779	0.8	98.8	0.4	Neutral
THYM	Thymoma	119	0.566	2.04e-11	6.7	92.4	0.8	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.436	2.81e-26	9.3	80.8	9.9	Neutral

Summary
Symbol	HDAC1
Name	histone deacetylase 1
Aliases	GON-10; RPD3L1; reduced potassium dependency, yeast homolog-like 1
Location	1p35.2-p35.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.274	1.04e-08	17	408	-0.01	0.00512	NS/NA
BRCA	Breast invasive carcinoma	-0.266	2.07e-15	83	785	0	0.704	NS/NA
CESC	Cervical and endocervical cancers	-0.178	0.00173	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.375	7.2e-12	19	297	0.002	0.00892	NS/NA
ESCA	Esophageal carcinoma	-0.228	0.00146	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.268	0.0311	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.214	5.37e-07	20	522	-0.003	0.228	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.292	4.11e-08	24	319	0.006	5.5e-11	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.318	2.35e-08	23	275	-0.006	5.36e-05	NS/NA
LAML	Acute Myeloid Leukemia	-0.157	0.0411	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.474	0	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.198	4.96e-05	41	373	0	0.302	NS/NA
LUAD	Lung adenocarcinoma	-0.138	0.00252	21	456	-0.012	0.206	NS/NA
LUSC	Lung squamous cell carcinoma	-0.144	0.0051	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.567	0.121	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.321	1.08e-05	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.475	5.54e-12	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.172	6.7e-05	35	498	-0.002	0.0186	NS/NA
READ	Rectum adenocarcinoma	-0.359	0.000252	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.447	0	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.261	9.68e-09	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.224	1.39e-05	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.461	2.04e-09	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.213	3.94e-07	50	509	-0.008	0.502	NS/NA
THYM	Thymoma	-0.238	0.00855	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.067	0.148	34	431	-0.001	0.214	NS/NA

Summary
Symbol	HDAC1
Name	histone deacetylase 1
Aliases	GON-10; RPD3L1; reduced potassium dependency, yeast homolog-like 1
Location	1p35.2-p35.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	0	Not detected
Appendix	3	High
Bone marrow	3	High
Breast	2	Medium
Bronchus	3	High
Caudate	1	Low
Cerebellum	0	Not detected
Cerebral cortex	1	Low
Cervix, uterine	3	High
Colon	3	High
Duodenum	3	High
Endometrium	2	Medium
Epididymis	3	High
Esophagus	3	High
Fallopian tube	3	High
Gallbladder	3	High
Heart muscle	1	Low
Hippocampus	0	Not detected
Kidney	2	Medium
Liver	2	Medium
Lung	2	Medium
Lymph node	2	Medium
Nasopharynx	2	Medium
Oral mucosa	3	High
Ovary	2	Medium
Pancreas	2	Medium
Parathyroid gland	2	Medium
Placenta	3	High
Prostate	2	Medium
Rectum	3	High
Salivary gland	2	Medium
Seminal vesicle	2	Medium
Skeletal muscle	0	Not detected
Skin	2	Medium
Small intestine	3	High
Smooth muscle	2	Medium
Soft tissue	2	Medium
Spleen	2	Medium
Stomach	3	High
Testis	2	Medium
Thyroid gland	3	High
Tonsil	3	High
Urinary bladder	3	High
Vagina	2	Medium

Summary
Symbol	HDAC1
Name	histone deacetylase 1
Aliases	GON-10; RPD3L1; reduced potassium dependency, yeast homolog-like 1
Location	1p35.2-p35.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.0832	NS	24476821
BRCA	Breast invasive carcinoma	521	3.82e-05	Significant	23000897
COAD	Colon adenocarcinoma	149	0.0253	Significant	22810696
GBM	Glioblastoma multiforme	157	0.028	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	6.05e-07	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.000324	Significant	26536169
LGG	Brain Lower Grade Glioma	513	2.93e-62	Significant	26824661
LUAD	Lung adenocarcinoma	230	0.399	NS	25079552
LUSC	Lung squamous cell carcinoma	178	9e-07	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.000967	Significant	21720365
PRAD	Prostate adenocarcinoma	333	2.52e-36	Significant	26544944
READ	Rectum adenocarcinoma	67	0.00452	Significant	22810696
SKCM	Skin Cutaneous Melanoma	315	0.448	NS	26091043
STAD	Stomach adenocarcinoma	277	1.21e-12	Significant	25079317
THCA	Thyroid carcinoma	391	1.37e-13	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.00033	Significant	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	1.028	0.901	NS
BRCA	Breast invasive carcinoma	1079	0.969	0.888	NS
CESC	Cervical and endocervical cancers	291	0.879	0.708	NS
COAD	Colon adenocarcinoma	439	0.833	0.514	NS
ESCA	Esophageal carcinoma	184	1.648	0.141	NS
GBM	Glioblastoma multiforme	158	0.915	0.718	NS
HNSC	Head and Neck squamous cell carcinoma	518	0.822	0.309	NS
KIRC	Kidney renal clear cell carcinoma	531	1.6	0.0197	Shorter
KIRP	Kidney renal papillary cell carcinoma	287	0.832	0.645	NS
LAML	Acute Myeloid Leukemia	149	1.897	0.0487	Shorter
LGG	Brain Lower Grade Glioma	511	4.19	5.04e-07	Shorter
LIHC	Liver hepatocellular carcinoma	365	2.228	0.000717	Shorter
LUAD	Lung adenocarcinoma	502	1.213	0.357	NS
LUSC	Lung squamous cell carcinoma	494	0.892	0.542	NS
OV	Ovarian serous cystadenocarcinoma	303	1.248	0.295	NS
PAAD	Pancreatic adenocarcinoma	177	1.518	0.152	NS
PCPG	Pheochromocytoma and Paraganglioma	179	0	0.0791	NS
PRAD	Prostate adenocarcinoma	497	3.901	0.198	NS
READ	Rectum adenocarcinoma	159	1.984	0.152	NS
SARC	Sarcoma	259	1.791	0.0485	Shorter
SKCM	Skin Cutaneous Melanoma	459	0.918	0.676	NS
STAD	Stomach adenocarcinoma	388	0.808	0.318	NS
TGCT	Testicular Germ Cell Tumors	134	0	0.235	NS
THCA	Thyroid carcinoma	500	0.18	0.0723	NS
THYM	Thymoma	119	0	0.0109	Longer
UCEC	Uterine Corpus Endometrial Carcinoma	543	1.029	0.921	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	-0.191	0.000105	Lower
BRCA	Breast invasive carcinoma	1071	-0.027	0.369	NS
CESC	Cervical and endocervical cancers	167	0.123	0.114	NS
COAD	Colon adenocarcinoma	445	-0.11	0.0199	Lower
ESCA	Esophageal carcinoma	162	0.004	0.96	NS
HNSC	Head and Neck squamous cell carcinoma	448	-0.024	0.617	NS
KIRC	Kidney renal clear cell carcinoma	531	0.046	0.292	NS
KIRP	Kidney renal papillary cell carcinoma	260	-0.061	0.326	NS
LIHC	Liver hepatocellular carcinoma	347	0.05	0.356	NS
LUAD	Lung adenocarcinoma	507	0.036	0.421	NS
LUSC	Lung squamous cell carcinoma	497	0.003	0.938	NS
OV	Ovarian serous cystadenocarcinoma	302	0.031	0.593	NS
PAAD	Pancreatic adenocarcinoma	176	0.139	0.0651	NS
READ	Rectum adenocarcinoma	156	0.041	0.613	NS
SKCM	Skin Cutaneous Melanoma	410	0.022	0.662	NS
STAD	Stomach adenocarcinoma	392	-0.129	0.0104	Lower
TGCT	Testicular Germ Cell Tumors	81	0.447	2.93e-05	Higher
THCA	Thyroid carcinoma	499	-0.024	0.597	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.032	0.468	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	-0.252	2.57e-05	Lower
HNSC	Head and Neck squamous cell carcinoma	498	-0.067	0.136	NS
KIRC	Kidney renal clear cell carcinoma	525	-0.062	0.155	NS
LGG	Brain Lower Grade Glioma	514	0.195	8.88e-06	Higher
LIHC	Liver hepatocellular carcinoma	366	0.184	0.000411	Higher
OV	Ovarian serous cystadenocarcinoma	296	0.138	0.0175	Higher
PAAD	Pancreatic adenocarcinoma	176	-0.042	0.58	NS
STAD	Stomach adenocarcinoma	406	-0.068	0.171	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.147	0.000656	Higher

Summary
Symbol	HDAC1
Name	histone deacetylase 1
Aliases	GON-10; RPD3L1; reduced potassium dependency, yeast homolog-like 1
Location	1p35.2-p35.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	HDAC1
Name	histone deacetylase 1
Aliases	GON-10; RPD3L1; reduced potassium dependency, yeast homolog-like 1
Location	1p35.2-p35.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database

[ TOP ]

DrugBank ID	Name	Type
DB02546	Vorinostat	Small Molecule Drug
DB05223	SB939	Small Molecule Drug
DB05651	MGCD-0103	Small Molecule Drug
DB05921	CRA-024781	Small Molecule Drug
DB06176	Romidepsin	Small Molecule Drug
DB05015	Belinostat	Small Molecule Drug
DB06603	Panobinostat	Small Molecule Drug
DB02546	Vorinostat	Small Molecule Drug
DB05223	SB939	Small Molecule Drug
DB05651	MGCD-0103	Small Molecule Drug
DB05921	CRA-024781	Small Molecule Drug
DB06176	Romidepsin	Small Molecule Drug
DB05015	Belinostat	Small Molecule Drug
DB06603	Panobinostat	Small Molecule Drug

Summary
Symbol	HDAC1
Name	histone deacetylase 1
Aliases	GON-10; RPD3L1; reduced potassium dependency, yeast homolog-like 1
Location	1p35.2-p35.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
23627572	Breast Carcinoma	partner	HER2	Positive correlation	Additionally, a high HDAC2 expression was significantly associated with an overexpression of HER2 (n=203, p=0.005) and the presence of nodal metastasis (n=200, p=0.04).HDAC1 was highly expressed in hormone receptor positive tumors (n=203; p<0.001).
27507654	Hepatocellular Carcinoma	downstream	MMP	positive regulation	HDAC1 regulated invasiveness by increasing matrix metalloproteinase (MMP) expression.
24762689	Non-Small Cell Lung Cancer	partner	DNMT1	Positive correlation	There was a positive association between the protein expressions of HDAC1 and DNMT1 in non-small-cell lung cancer (r = 0.525, P = 0.000).
24668547	Gastric Carcinoma	partner	CDKN1A	Positive correlation	The mRNA level of MYC was correlated to HDAC3 and GCN5 (P < 0.05), whereas CDKN1A was correlated to HDAC1 and GCN5 (P < 0.05 and P < 0.01, respectively).
21982637	Intrahepatic Cholangiocarcinoma	partner	HIF-1α	Positive correlation	Furthermore, there was a significant correlation between HDAC1 expression and HIF-1α expression (P = .007).
21685935	Nasopharyngeal Carcinoma	partner	EZH2	Complex Formation	The data provided in this report suggest a critical role of EZH2 in the control of cell invasion and/or metastasis by forming a co-repressor complex with HDAC1/HDAC2/Snail to repress E-cadherin, an activity that might be responsible, at least in part, for the development and/or progression of human NPCs.
21617866	Colon Carcinoma	partner	MTA1	Positive correlation	HDAC1 and MTA1 expression levels were significantly related to poorer prognosis
28502558	Gastric Carcinoma	partner	MTA2	Positive correlation	The co-expression of MTA2 and HDAC1 in gastric cancer achieved 65.3% sensitivity (95% CI: 51.5%-79.1%) and 65.2% specificity (95% CI: 50.9%-79.5%), which was strongly associated with lymph node metastasis and TNM staging.
28262837	Hepatocellular Carcinoma	partner	FBP1	Negative correlation	Low expression of FBP1 correlated with high levels of histone deacetylase 1 (HDAC1) and HDAC2 proteins in HCC patient tissues.