CR2Cancer

Summary
Symbol	HDAC3
Name	histone deacetylase 3
Aliases	HD3; RPD3-2; SMAP45
Location	5q31.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

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Domain

PF00850 Histone deacetylase domain

Function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation (PubMed:21444723, PubMed:23911289). Contributes, together with XBP1 isoform 1, to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI(3)K/mTORC2/Akt-dependent signaling pathway leading to endothelial cell (EC) survival under disturbed flow/oxidative stress (PubMed:25190803).

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification erase	Histone acetylation	H2AKac, H2BKac, H3Kac, H4Kac	H2AK, H2BK, H3K, H4K	10655483

> Gene Ontology [ TOP ]
Biological Process	GO:0000226 microtubule cytoskeleton organization GO:0001933 negative regulation of protein phosphorylation GO:0006476 protein deacetylation GO:0006606 protein import into nucleus GO:0006913 nucleocytoplasmic transport GO:0007051 spindle organization GO:0007254 JNK cascade GO:0007623 circadian rhythm GO:0016570 histone modification GO:0016575 histone deacetylation GO:0017038 protein import GO:0031098 stress-activated protein kinase signaling cascade GO:0031647 regulation of protein stability GO:0031929 TOR signaling GO:0032006 regulation of TOR signaling GO:0032008 positive regulation of TOR signaling GO:0032386 regulation of intracellular transport GO:0032388 positive regulation of intracellular transport GO:0032872 regulation of stress-activated MAPK cascade GO:0032873 negative regulation of stress-activated MAPK cascade GO:0033157 regulation of intracellular protein transport GO:0034405 response to fluid shear stress GO:0034504 protein localization to nucleus GO:0035601 protein deacylation GO:0042306 regulation of protein import into nucleus GO:0042307 positive regulation of protein import into nucleus GO:0042326 negative regulation of phosphorylation GO:0042990 regulation of transcription factor import into nucleus GO:0042991 transcription factor import into nucleus GO:0042993 positive regulation of transcription factor import into nucleus GO:0043409 negative regulation of MAPK cascade GO:0044744 protein targeting to nucleus GO:0046328 regulation of JNK cascade GO:0046329 negative regulation of JNK cascade GO:0046822 regulation of nucleocytoplasmic transport GO:0046824 positive regulation of nucleocytoplasmic transport GO:0048511 rhythmic process GO:0051169 nuclear transport GO:0051170 nuclear import GO:0051222 positive regulation of protein transport GO:0051225 spindle assembly GO:0051403 stress-activated MAPK cascade GO:0070302 regulation of stress-activated protein kinase signaling cascade GO:0070303 negative regulation of stress-activated protein kinase signaling cascade GO:0070932 histone H3 deacetylation GO:0071498 cellular response to fluid shear stress GO:0090316 positive regulation of intracellular protein transport GO:0098732 macromolecule deacylation GO:1900180 regulation of protein localization to nucleus GO:1900182 positive regulation of protein localization to nucleus GO:1902532 negative regulation of intracellular signal transduction GO:1902593 single-organism nuclear import GO:1903533 regulation of protein targeting GO:1903829 positive regulation of cellular protein localization GO:1904589 regulation of protein import GO:1904591 positive regulation of protein import GO:1904951 positive regulation of establishment of protein localization
Molecular Function	GO:0003682 chromatin binding GO:0003714 transcription corepressor activity GO:0004407 histone deacetylase activity GO:0008134 transcription factor binding GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides GO:0017136 NAD-dependent histone deacetylase activity GO:0019213 deacetylase activity GO:0030332 cyclin binding GO:0031078 histone deacetylase activity (H3-K14 specific) GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific) GO:0033558 protein deacetylase activity GO:0034979 NAD-dependent protein deacetylase activity GO:0042826 histone deacetylase binding GO:0051059 NF-kappaB binding
Cellular Component	GO:0000118 histone deacetylase complex GO:0005819 spindle GO:0005874 microtubule GO:0005876 spindle microtubule GO:0017053 transcriptional repressor complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04919 Thyroid hormone signaling pathway
Reactome	R-HSA-5619507: Activation of HOX genes during differentiation R-HSA-5617472: Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-390471: Association of TriC/CCT with target proteins during biosynthesis R-HSA-1368108: BMAL1 R-HSA-390466: Chaperonin-mediated protein folding R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-400253: Circadian Clock R-HSA-2894862: Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2644606: Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-1266738: Developmental Biology R-HSA-1643685: Disease R-HSA-5663202: Diseases of signal transduction R-HSA-535734: Fatty acid, triacylglycerol, and ketone body metabolism R-HSA-3214815: HDACs deacetylate histones R-HSA-1430728: Metabolism R-HSA-556833: Metabolism of lipids and lipoproteins R-HSA-392499: Metabolism of proteins R-HSA-1592230: Mitochondrial biogenesis R-HSA-2122947: NOTCH1 Intracellular Domain Regulates Transcription R-HSA-1368071: NR1D1 (REV-ERBA) represses gene expression R-HSA-1852241: Organelle biogenesis and maintenance R-HSA-1989781: PPARA activates gene expression R-HSA-391251: Protein folding R-HSA-1368082: RORA activates gene expression R-HSA-400206: Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) R-HSA-162582: Signal Transduction R-HSA-157118: Signaling by NOTCH R-HSA-1980143: Signaling by NOTCH1 R-HSA-2894858: Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2644602: Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644603: Signaling by NOTCH1 in Cancer R-HSA-166520: Signalling by NGF R-HSA-2151201: Transcriptional activation of mitochondrial biogenesis R-HSA-381340: Transcriptional regulation of white adipocyte differentiation R-HSA-193704: p75 NTR receptor-mediated signalling R-HSA-193670: p75NTR negatively regulates cell cycle via SC1

> KEGG and Reactome Pathway

[ TOP ]

KEGG

hsa04919 Thyroid hormone signaling pathway

Reactome

R-HSA-5619507: Activation of HOX genes during differentiation
R-HSA-5617472: Activation of anterior HOX genes in hindbrain development during early embryogenesis
R-HSA-390471: Association of TriC/CCT with target proteins during biosynthesis
R-HSA-1368108: BMAL1
R-HSA-390466: Chaperonin-mediated protein folding
R-HSA-3247509: Chromatin modifying enzymes
R-HSA-4839726: Chromatin organization
R-HSA-400253: Circadian Clock
R-HSA-2894862: Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
R-HSA-2644606: Constitutive Signaling by NOTCH1 PEST Domain Mutants
R-HSA-1266738: Developmental Biology
R-HSA-1643685: Disease
R-HSA-5663202: Diseases of signal transduction
R-HSA-535734: Fatty acid, triacylglycerol, and ketone body metabolism
R-HSA-3214815: HDACs deacetylate histones
R-HSA-1430728: Metabolism
R-HSA-556833: Metabolism of lipids and lipoproteins
R-HSA-392499: Metabolism of proteins
R-HSA-1592230: Mitochondrial biogenesis
R-HSA-2122947: NOTCH1 Intracellular Domain Regulates Transcription
R-HSA-1368071: NR1D1 (REV-ERBA) represses gene expression
R-HSA-1852241: Organelle biogenesis and maintenance
R-HSA-1989781: PPARA activates gene expression
R-HSA-391251: Protein folding
R-HSA-1368082: RORA activates gene expression
R-HSA-400206: Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
R-HSA-162582: Signal Transduction
R-HSA-157118: Signaling by NOTCH
R-HSA-1980143: Signaling by NOTCH1
R-HSA-2894858: Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
R-HSA-2644602: Signaling by NOTCH1 PEST Domain Mutants in Cancer
R-HSA-2644603: Signaling by NOTCH1 in Cancer
R-HSA-166520: Signalling by NGF
R-HSA-2151201: Transcriptional activation of mitochondrial biogenesis
R-HSA-381340: Transcriptional regulation of white adipocyte differentiation
R-HSA-193704: p75 NTR receptor-mediated signalling
R-HSA-193670: p75NTR negatively regulates cell cycle via SC1

Summary
Symbol	HDAC3
Name	histone deacetylase 3
Aliases	HD3; RPD3-2; SMAP45
Location	5q31.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM234248	c.793C>T	p.R265*	Substitution - Nonsense	Skin
COSM3381144	c.315G>A	p.S105S	Substitution - coding silent	Pancreas
COSM1434735	c.838G>A	p.V280I	Substitution - Missense	Stomach
COSM3381144	c.315G>A	p.S105S	Substitution - coding silent	Pancreas
COSM5008517	c.36C>T	p.D12D	Substitution - coding silent	Large_intestine
COSM1642642	c.273C>T	p.G91G	Substitution - coding silent	Stomach
COSM3852229	c.998C>T	p.A333V	Substitution - Missense	Stomach
COSM1063505	c.328G>A	p.A110T	Substitution - Missense	Endometrium
COSM4606467	c.884G>A	p.G295D	Substitution - Missense	Large_intestine
COSM5463400	c.49C>A	p.H17N	Substitution - Missense	Large_intestine
COSM3786875	c.179G>A	p.R60H	Substitution - Missense	Pancreas
COSM3611754	c.477-1G>A	p.?	Unknown	Skin
COSM123549	c.902G>T	p.R301L	Substitution - Missense	Upper_aerodigestive_tract
COSM3852228	c.1137C>T	p.D379D	Substitution - coding silent	Stomach
COSM223030	c.272G>A	p.G91D	Substitution - Missense	Skin
COSM3429111	c.477-1G>T	p.?	Unknown	Large_intestine
COSM4564444	c.1198_1199CC>TT	p.P400F	Substitution - Missense	Skin
COSM5709540	c.566C>T	p.T189M	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3209047	c.571T>C	p.S191P	Substitution - Missense	Large_intestine
COSM4420935	c.139-10C>A	p.?	Unknown	Prostate
COSM1619761	c.476+10C>A	p.?	Unknown	Liver
COSM3611751	c.1118C>T	p.P373L	Substitution - Missense	Skin
COSM5356973	c.234G>A	p.M78I	Substitution - Missense	Large_intestine
COSM5779711	c.329C>T	p.A110V	Substitution - Missense	Breast
COSM3852232	c.202G>A	p.D68N	Substitution - Missense	Stomach
COSM4429669	c.460A>G	p.I154V	Substitution - Missense	Oesophagus
COSM4488463	c.332C>T	p.S111F	Substitution - Missense	Skin
COSM5947885	c.791A>T	p.D264V	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1310786	c.567G>A	p.T189T	Substitution - coding silent	Urinary_tract
COSM3761008	c.165A>G	p.Q55Q	Substitution - coding silent	Thyroid
COSM449007	c.1012C>T	p.L338F	Substitution - Missense	Breast
COSM4817495	c.1271G>A	p.S424N	Substitution - Missense	Cervix
COSM3611755	c.302T>C	p.F101S	Substitution - Missense	Skin
COSM5912245	c.308T>A	p.F103Y	Substitution - Missense	Skin
COSM3611757	c.189C>T	p.S63S	Substitution - coding silent	Skin
COSM1434735	c.838G>A	p.V280I	Substitution - Missense	Large_intestine
COSM5490735	c.68C>T	p.P23L	Substitution - Missense	Biliary_tract
COSM4565232	c.188_189CC>AT	p.S63Y	Substitution - Missense	Skin
COSM3611753	c.532C>T	p.Q178*	Substitution - Nonsense	Skin
COSM5730014	c.741C>T	p.Y247Y	Substitution - coding silent	Skin
COSM736587	c.949G>T	p.E317*	Substitution - Nonsense	Lung
COSM1696440	c.314C>T	p.S105L	Substitution - Missense	Skin
COSM1063493	c.988G>A	p.E330K	Substitution - Missense	Endometrium
COSM3852233	c.178C>T	p.R60C	Substitution - Missense	Stomach
COSM1063509	c.268G>A	p.V90I	Substitution - Missense	Endometrium
COSM5402548	c.428G>A	p.G143D	Substitution - Missense	Skin
COSM5743089	c.290T>C	p.F97S	Substitution - Missense	Small_intestine
COSM3381144	c.315G>A	p.S105S	Substitution - coding silent	Pancreas
COSM3661546	c.936G>A	p.S312S	Substitution - coding silent	Liver
COSM234248	c.793C>T	p.R265*	Substitution - Nonsense	Skin
COSM1063513	c.155A>G	p.Q52R	Substitution - Missense	Endometrium
COSM1063511	c.221G>A	p.S74N	Substitution - Missense	Endometrium
COSM1063495	c.980-1G>T	p.?	Unknown	Endometrium
COSM4606467	c.884G>A	p.G295D	Substitution - Missense	Large_intestine
COSM1642642	c.273C>T	p.G91G	Substitution - coding silent	Stomach
COSM116301	c.526G>C	p.G176R	Substitution - Missense	Ovary
COSM1319251	c.443A>G	p.N148S	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5474782	c.1076G>A	p.R359H	Substitution - Missense	Large_intestine
COSM373686	c.334C>T	p.L112L	Substitution - coding silent	Lung
COSM5450088	c.890G>A	p.G297D	Substitution - Missense	Large_intestine
COSM4457740	c.1057C>T	p.Q353*	Substitution - Nonsense	Skin
COSM5026424	c.1015C>A	p.H339N	Substitution - Missense	Breast
COSM5356973	c.234G>A	p.M78I	Substitution - Missense	Large_intestine
COSM311721	c.313T>C	p.S105P	Substitution - Missense	Lung
COSM1719036	c.1098G>T	p.L366L	Substitution - coding silent	Skin
COSM3852230	c.660C>T	p.N220N	Substitution - coding silent	Stomach
COSM3209040	c.837C>T	p.C279C	Substitution - coding silent	Large_intestine
COSM3611758	c.109C>A	p.L37M	Substitution - Missense	Skin
COSM234249	c.820C>T	p.R274*	Substitution - Nonsense	Skin
COSM3768204	c.893A>T	p.Y298F	Substitution - Missense	Liver
COSM4929064	c.696C>G	p.Y232*	Substitution - Nonsense	Liver
COSM69355	c.420+1G>T	p.?	Unknown	Ovary
COSM4619589	c.926A>G	p.Y309C	Substitution - Missense	Large_intestine
COSM3209032	c.1261G>T	p.D421Y	Substitution - Missense	Large_intestine
COSM1063507	c.295G>A	p.G99R	Substitution - Missense	Endometrium
COSM4819427	c.708C>G	p.F236L	Substitution - Missense	Cervix
COSM1310786	c.567G>A	p.T189T	Substitution - coding silent	Liver
COSM3661546	c.936G>A	p.S312S	Substitution - coding silent	Stomach
COSM1619760	c.980-3A>T	p.?	Unknown	Liver
COSM3611752	c.665C>T	p.P222L	Substitution - Missense	Skin
COSM1063501	c.643C>T	p.R215C	Substitution - Missense	Endometrium
COSM5931665	c.908T>C	p.V303A	Substitution - Missense	Skin
COSM1063515	c.132G>T	p.K44N	Substitution - Missense	Endometrium
COSM3669422	c.489G>A	p.R163R	Substitution - coding silent	Liver
COSM4839351	c.803G>A	p.C268Y	Substitution - Missense	Cervix
COSM3852231	c.317G>A	p.R106H	Substitution - Missense	Stomach
COSM1619761	c.476+10C>A	p.?	Unknown	Liver
COSM1063499	c.750G>A	p.T250T	Substitution - coding silent	Endometrium
COSM5041063	c.338A>G	p.Q113R	Substitution - Missense	Liver
COSM5512162	c.445G>A	p.D149N	Substitution - Missense	Biliary_tract
COSM4159579	c.685G>T	p.D229Y	Substitution - Missense	Thyroid
COSM1063491	c.1041G>T	p.E347D	Substitution - Missense	Endometrium
COSM3611756	c.292C>T	p.P98S	Substitution - Missense	Skin
COSM1063505	c.328G>A	p.A110T	Substitution - Missense	Endometrium
COSM1719036	c.1098G>T	p.L366L	Substitution - coding silent	Skin
COSM1209376	c.71T>C	p.M24T	Substitution - Missense	Large_intestine
COSM1063503	c.510C>T	p.D170D	Substitution - coding silent	Endometrium
COSM1619760	c.980-3A>T	p.?	Unknown	Liver
COSM3669422	c.489G>A	p.R163R	Substitution - coding silent	Liver
COSM234249	c.820C>T	p.R274*	Substitution - Nonsense	Liver
COSM3209040	c.837C>T	p.C279C	Substitution - coding silent	Large_intestine
COSM3761008	c.165A>G	p.Q55Q	Substitution - coding silent	Large_intestine
COSM1619760	c.980-3A>T	p.?	Unknown	Liver
COSM1063507	c.295G>A	p.G99R	Substitution - Missense	Endometrium
COSM5756586	c.547C>G	p.L183V	Substitution - Missense	Large_intestine
COSM244869	c.277G>A	p.D93N	Substitution - Missense	Prostate
COSM1063497	c.915C>G	p.R305R	Substitution - coding silent	Endometrium
COSM3852234	c.16G>A	p.A6T	Substitution - Missense	Stomach

> Text Mining based Variations [ TOP ]
There is no record for HDAC3.

Summary
Symbol	HDAC3
Name	histone deacetylase 3
Aliases	HD3; RPD3-2; SMAP45
Location	5q31.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

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Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant

Summary
Symbol	HDAC3
Name	histone deacetylase 3
Aliases	HD3; RPD3-2; SMAP45
Location	5q31.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

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Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	5.667	5.856	0.151	0.224	NS
BRCA	Breast invasive carcinoma	112	1100	5.606	5.764	0.148	7.09e-05	NS
CESC	Cervical and endocervical cancers	3	306	6.066	6.043	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	5.559	5.848	0.279	7.14e-07	NS
ESCA	Esophageal carcinoma	11	185	4.962	5.077	0.024	0.91	NS
GBM	Glioblastoma multiforme	5	166	5.27	6.054	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	5.759	5.891	0.109	0.13	NS
KIRC	Kidney renal clear cell carcinoma	72	534	5.317	5.792	0.433	5.53e-21	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	5.48	5.449	-0.002	0.975	NS
LAML	Acute Myeloid Leukemia	0	173	NA	5.572	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	5.31	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	5.071	5.122	0.045	0.557	NS
LUAD	Lung adenocarcinoma	59	517	5.444	5.737	0.269	4.09e-06	NS
LUSC	Lung squamous cell carcinoma	51	501	5.43	5.853	0.426	1.34e-13	NS
OV	Ovarian serous cystadenocarcinoma	0	307	NA	5.532	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	5.642	5.529	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	5.886	5.389	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	5.621	5.801	0.236	1.78e-07	NS
READ	Rectum adenocarcinoma	10	167	5.395	5.842	0.313	0.0214	NS
SARC	Sarcoma	2	263	5.592	5.831	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	6.019	5.736	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	5.278	5.102	-0.199	0.0137	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	6.172	NA	NA	NA
THCA	Thyroid carcinoma	59	509	5.68	5.564	-0.132	0.00119	NS
THYM	Thymoma	2	120	5.822	5.986	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	5.579	5.588	0.018	0.853	NS

> Cancer Cell Line Encyclopedia (CCLE)

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Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	8.4
Autonomic ganglia	CHP212	8.7
Autonomic ganglia	IMR32	8.7
Autonomic ganglia	KELLY	9
Autonomic ganglia	KPNRTBM1	8.5
Autonomic ganglia	KPNSI9S	8.5
Autonomic ganglia	KPNYN	8.5
Autonomic ganglia	MHHNB11	8.4
Autonomic ganglia	NB1	8.1
Autonomic ganglia	NH6	8.5
Autonomic ganglia	SHSY5Y	8.7
Autonomic ganglia	SIMA	8.5
Autonomic ganglia	SKNAS	9
Autonomic ganglia	SKNBE2	8.9
Autonomic ganglia	SKNDZ	9.3
Autonomic ganglia	SKNFI	8.7
Autonomic ganglia	SKNSH	9
Biliary tract	HUCCT1	9.2
Biliary tract	HUH28	9
Biliary tract	SNU1079	8.4
Biliary tract	SNU1196	8
Biliary tract	SNU245	9.2
Biliary tract	SNU308	9.3
Biliary tract	SNU478	8.8
Bone	143B	9
Bone	A673	9
Bone	CADOES1	8.4
Bone	CAL78	9.1
Bone	G292CLONEA141B1	9
Bone	HOS	8.8
Bone	HS706T	8.7
Bone	HS737T	8.6
Bone	HS819T	8.5
Bone	HS821T	8.3
Bone	HS822T	8.6
Bone	HS863T	8.4
Bone	HS870T	8.9
Bone	HS888T	8.5
Bone	MG63	9.7
Bone	MHHES1	8.7
Bone	OUMS27	8.6
Bone	RDES	9
Bone	SJSA1	9.5
Bone	SKES1	9.1
Bone	SKNMC	9.2
Bone	SW1353	9
Bone	T173	8.6
Bone	TC71	8.9
Bone	U2OS	8.8
Breast	AU565	9.4
Breast	BT20	8.9
Breast	BT474	8.7
Breast	BT483	8.8
Breast	BT549	9
Breast	CAL120	9.1
Breast	CAL148	9.1
Breast	CAL51	9
Breast	CAL851	8.4
Breast	CAMA1	9.8
Breast	DU4475	9.3
Breast	EFM192A	9
Breast	EFM19	8.1
Breast	EVSAT	9
Breast	HCC1143	8.8
Breast	HCC1187	9.1
Breast	HCC1395	9.3
Breast	HCC1419	8.5
Breast	HCC1428	8.2
Breast	HCC1500	8.7
Breast	HCC1569	9.3
Breast	HCC1599	8.9
Breast	HCC1806	9.1
Breast	HCC1937	9
Breast	HCC1954	8.7
Breast	HCC202	9.1
Breast	HCC2157	9.4
Breast	HCC2218	8.9
Breast	HCC38	8.9
Breast	HCC70	8.7
Breast	HDQP1	8.8
Breast	HMC18	9
Breast	HS274T	8.2
Breast	HS281T	8.3
Breast	HS343T	8.2
Breast	HS578T	9.4
Breast	HS606T	8.6
Breast	HS739T	8.5
Breast	HS742T	8.8
Breast	JIMT1	8.5
Breast	KPL1	9.2
Breast	MCF7	8.9
Breast	MDAMB134VI	9.1
Breast	MDAMB157	10.4
Breast	MDAMB175VII	8.9
Breast	MDAMB231	9.3
Breast	MDAMB361	8.6
Breast	MDAMB415	9.7
Breast	MDAMB436	8.8
Breast	MDAMB453	9.1
Breast	MDAMB468	9.3
Breast	SKBR3	9
Breast	T47D	9.2
Breast	UACC812	8.6
Breast	UACC893	7.9
Breast	YMB1	8.9
Breast	ZR751	8.7
Breast	ZR7530	8.3
Central nervous system	1321N1	9.1
Central nervous system	42MGBA	9
Central nervous system	8MGBA	8.5
Central nervous system	A172	8.9
Central nervous system	AM38	8.9
Central nervous system	BECKER	9.3
Central nervous system	CAS1	9.2
Central nervous system	CCFSTTG1	8.5
Central nervous system	D283MED	8.9
Central nervous system	D341MED	8.5
Central nervous system	DAOY	8.7
Central nervous system	DBTRG05MG	8.9
Central nervous system	DKMG	7.8
Central nervous system	GAMG	9.3
Central nervous system	GB1	8.7
Central nervous system	GI1	9.1
Central nervous system	GMS10	8.7
Central nervous system	GOS3	8.7
Central nervous system	H4	8.6
Central nervous system	HS683	9.1
Central nervous system	KALS1	9.1
Central nervous system	KG1C	9.6
Central nervous system	KNS42	8.9
Central nervous system	KNS60	8.8
Central nervous system	KNS81	8.9
Central nervous system	KS1	9.1
Central nervous system	LN18	9.8
Central nervous system	LN229	9.1
Central nervous system	M059K	9.2
Central nervous system	MOGGCCM	9.1
Central nervous system	MOGGUVW	8.6
Central nervous system	NMCG1	9.3
Central nervous system	ONS76	9.3
Central nervous system	SF126	9.1
Central nervous system	SF295	9.3
Central nervous system	SNB19	9
Central nervous system	SNU1105	9.1
Central nervous system	SNU201	9.3
Central nervous system	SNU466	8.8
Central nervous system	SNU489	9.3
Central nervous system	SNU626	8.5
Central nervous system	SNU738	8.5
Central nervous system	SW1088	10.1
Central nervous system	SW1783	9.3
Central nervous system	T98G	9.6
Central nervous system	TM31	8.3
Central nervous system	U118MG	8.3
Central nervous system	U138MG	8.7
Central nervous system	U251MG	9.2
Central nervous system	U87MG	8.5
Central nervous system	YH13	9.1
Central nervous system	YKG1	8.9
Endometrium	AN3CA	9.9
Endometrium	COLO684	8.6
Endometrium	EFE184	8.6
Endometrium	EN	8.9
Endometrium	ESS1	9.1
Endometrium	HEC108	8.8
Endometrium	HEC151	8.8
Endometrium	HEC1A	9.6
Endometrium	HEC1B	9.4
Endometrium	HEC251	8
Endometrium	HEC265	9.2
Endometrium	HEC50B	9.3
Endometrium	HEC59	9.4
Endometrium	HEC6	9.5
Endometrium	ISHIKAWAHERAKLIO02ER	8.6
Endometrium	JHUEM1	8.6
Endometrium	JHUEM2	8.8
Endometrium	JHUEM3	8.7
Endometrium	KLE	9.5
Endometrium	MFE280	9
Endometrium	MFE296	9.5
Endometrium	MFE319	8.7
Endometrium	RL952	9.1
Endometrium	SNGM	8.8
Endometrium	SNU1077	8.7
Endometrium	SNU685	8.8
Endometrium	TEN	9.3
Haematopoietic and lymphoid	697	9.2
Haematopoietic and lymphoid	A3KAW	9.4
Haematopoietic and lymphoid	A4FUK	9.1
Haematopoietic and lymphoid	ALLSIL	8.9
Haematopoietic and lymphoid	AML193	9
Haematopoietic and lymphoid	AMO1	8.8
Haematopoietic and lymphoid	BCP1	9.5
Haematopoietic and lymphoid	BDCM	9.7
Haematopoietic and lymphoid	BL41	9.3
Haematopoietic and lymphoid	BL70	9.4
Haematopoietic and lymphoid	BV173	8.6
Haematopoietic and lymphoid	CA46	9.1
Haematopoietic and lymphoid	CI1	9.8
Haematopoietic and lymphoid	CMK115	9.1
Haematopoietic and lymphoid	CMK86	9
Haematopoietic and lymphoid	CMK	8.8
Haematopoietic and lymphoid	CMLT1	9.3
Haematopoietic and lymphoid	COLO775	8.4
Haematopoietic and lymphoid	DAUDI	9.1
Haematopoietic and lymphoid	DB	9.1
Haematopoietic and lymphoid	DEL	9.4
Haematopoietic and lymphoid	DND41	9.7
Haematopoietic and lymphoid	DOHH2	9.1
Haematopoietic and lymphoid	EB1	9.3
Haematopoietic and lymphoid	EB2	9.5
Haematopoietic and lymphoid	EHEB	9
Haematopoietic and lymphoid	EJM	8.4
Haematopoietic and lymphoid	EM2	8.9
Haematopoietic and lymphoid	EOL1	9.4
Haematopoietic and lymphoid	F36P	9.1
Haematopoietic and lymphoid	GA10	9.4
Haematopoietic and lymphoid	GDM1	9
Haematopoietic and lymphoid	GRANTA519	8.5
Haematopoietic and lymphoid	HDLM2	9.4
Haematopoietic and lymphoid	HDMYZ	8.7
Haematopoietic and lymphoid	HEL9217	9.5
Haematopoietic and lymphoid	HEL	9
Haematopoietic and lymphoid	HH	9.9
Haematopoietic and lymphoid	HL60	9.3
Haematopoietic and lymphoid	HPBALL	9.4
Haematopoietic and lymphoid	HS604T	8.3
Haematopoietic and lymphoid	HS611T	9.5
Haematopoietic and lymphoid	HS616T	8.8
Haematopoietic and lymphoid	HS751T	7.5
Haematopoietic and lymphoid	HT	9.3
Haematopoietic and lymphoid	HTK	8.4
Haematopoietic and lymphoid	HUNS1	9.3
Haematopoietic and lymphoid	HUT102	9.7
Haematopoietic and lymphoid	HUT78	9.5
Haematopoietic and lymphoid	JEKO1	9.6
Haematopoietic and lymphoid	JK1	8.5
Haematopoietic and lymphoid	JM1	9
Haematopoietic and lymphoid	JURKAT	9.1
Haematopoietic and lymphoid	JURLMK1	8.4
Haematopoietic and lymphoid	JVM2	8.8
Haematopoietic and lymphoid	JVM3	8.7
Haematopoietic and lymphoid	K562	9.3
Haematopoietic and lymphoid	KARPAS299	9.1
Haematopoietic and lymphoid	KARPAS422	9.4
Haematopoietic and lymphoid	KARPAS620	8.7
Haematopoietic and lymphoid	KASUMI1	8.3
Haematopoietic and lymphoid	KASUMI2	9
Haematopoietic and lymphoid	KASUMI6	8.8
Haematopoietic and lymphoid	KCL22	8.9
Haematopoietic and lymphoid	KE37	8.9
Haematopoietic and lymphoid	KE97	9.6
Haematopoietic and lymphoid	KG1	8.4
Haematopoietic and lymphoid	KHM1B	8.2
Haematopoietic and lymphoid	KIJK	9.9
Haematopoietic and lymphoid	KMH2	8.6
Haematopoietic and lymphoid	KMM1	9.2
Haematopoietic and lymphoid	KMS11	8.7
Haematopoietic and lymphoid	KMS12BM	8.7
Haematopoietic and lymphoid	KMS18	9.2
Haematopoietic and lymphoid	KMS20	8.9
Haematopoietic and lymphoid	KMS21BM	8.2
Haematopoietic and lymphoid	KMS26	8.5
Haematopoietic and lymphoid	KMS27	8.8
Haematopoietic and lymphoid	KMS28BM	8.6
Haematopoietic and lymphoid	KMS34	8
Haematopoietic and lymphoid	KO52	9.1
Haematopoietic and lymphoid	KOPN8	9.4
Haematopoietic and lymphoid	KU812	8.9
Haematopoietic and lymphoid	KYO1	9.7
Haematopoietic and lymphoid	L1236	10.1
Haematopoietic and lymphoid	L363	9
Haematopoietic and lymphoid	L428	8.7
Haematopoietic and lymphoid	L540	9.5
Haematopoietic and lymphoid	LAMA84	9.1
Haematopoietic and lymphoid	LOUCY	8.9
Haematopoietic and lymphoid	LP1	8.1
Haematopoietic and lymphoid	M07E	8.8
Haematopoietic and lymphoid	MC116	9.2
Haematopoietic and lymphoid	ME1	9.6
Haematopoietic and lymphoid	MEC1	8.8
Haematopoietic and lymphoid	MEC2	9
Haematopoietic and lymphoid	MEG01	9.8
Haematopoietic and lymphoid	MHHCALL2	8.7
Haematopoietic and lymphoid	MHHCALL3	8.8
Haematopoietic and lymphoid	MHHCALL4	8.5
Haematopoietic and lymphoid	MINO	9.1
Haematopoietic and lymphoid	MJ	9.4
Haematopoietic and lymphoid	MM1S	9.1
Haematopoietic and lymphoid	MOLM13	9.2
Haematopoietic and lymphoid	MOLM16	9.1
Haematopoietic and lymphoid	MOLM6	9
Haematopoietic and lymphoid	MOLP2	8.4
Haematopoietic and lymphoid	MOLP8	8.2
Haematopoietic and lymphoid	MOLT13	9.4
Haematopoietic and lymphoid	MOLT16	9
Haematopoietic and lymphoid	MOLT4	9.8
Haematopoietic and lymphoid	MONOMAC1	9.4
Haematopoietic and lymphoid	MONOMAC6	9.1
Haematopoietic and lymphoid	MOTN1	10.2
Haematopoietic and lymphoid	MUTZ5	9.1
Haematopoietic and lymphoid	MV411	9.6
Haematopoietic and lymphoid	NALM19	9.4
Haematopoietic and lymphoid	NALM1	8.8
Haematopoietic and lymphoid	NALM6	9.1
Haematopoietic and lymphoid	NAMALWA	8.7
Haematopoietic and lymphoid	NB4	9.2
Haematopoietic and lymphoid	NCIH929	9.3
Haematopoietic and lymphoid	NCO2	9.3
Haematopoietic and lymphoid	NOMO1	9.3
Haematopoietic and lymphoid	NUDHL1	10.2
Haematopoietic and lymphoid	NUDUL1	9.1
Haematopoietic and lymphoid	OCIAML2	9.6
Haematopoietic and lymphoid	OCIAML3	9.1
Haematopoietic and lymphoid	OCIAML5	9.3
Haematopoietic and lymphoid	OCILY10	9.8
Haematopoietic and lymphoid	OCILY19	9.3
Haematopoietic and lymphoid	OCILY3	9.6
Haematopoietic and lymphoid	OCIM1	8.9
Haematopoietic and lymphoid	OPM2	7.6
Haematopoietic and lymphoid	P12ICHIKAWA	9.5
Haematopoietic and lymphoid	P31FUJ	9
Haematopoietic and lymphoid	P3HR1	9.4
Haematopoietic and lymphoid	PCM6	9.5
Haematopoietic and lymphoid	PEER	9.5
Haematopoietic and lymphoid	PF382	9.2
Haematopoietic and lymphoid	PFEIFFER	9.6
Haematopoietic and lymphoid	PL21	8.9
Haematopoietic and lymphoid	RAJI	9.4
Haematopoietic and lymphoid	RCHACV	9
Haematopoietic and lymphoid	REC1	9.2
Haematopoietic and lymphoid	REH	9.6
Haematopoietic and lymphoid	RI1	9.9
Haematopoietic and lymphoid	RL	9.4
Haematopoietic and lymphoid	RPMI8226	8.7
Haematopoietic and lymphoid	RPMI8402	9.4
Haematopoietic and lymphoid	RS411	9.2
Haematopoietic and lymphoid	SEM	9
Haematopoietic and lymphoid	SET2	8.5
Haematopoietic and lymphoid	SIGM5	9.5
Haematopoietic and lymphoid	SKM1	9.5
Haematopoietic and lymphoid	SKMM2	8.4
Haematopoietic and lymphoid	SR786	8.8
Haematopoietic and lymphoid	ST486	9.2
Haematopoietic and lymphoid	SUDHL10	9.8
Haematopoietic and lymphoid	SUDHL1	9.1
Haematopoietic and lymphoid	SUDHL4	9.4
Haematopoietic and lymphoid	SUDHL5	9.1
Haematopoietic and lymphoid	SUDHL6	9.5
Haematopoietic and lymphoid	SUDHL8	8.6
Haematopoietic and lymphoid	SUPB15	9.2
Haematopoietic and lymphoid	SUPHD1	9.1
Haematopoietic and lymphoid	SUPM2	8.7
Haematopoietic and lymphoid	SUPT11	9.7
Haematopoietic and lymphoid	SUPT1	9.3
Haematopoietic and lymphoid	TALL1	9.4
Haematopoietic and lymphoid	TF1	9.5
Haematopoietic and lymphoid	THP1	9.3
Haematopoietic and lymphoid	TO175T	8.8
Haematopoietic and lymphoid	TOLEDO	9.1
Haematopoietic and lymphoid	U266B1	8.5
Haematopoietic and lymphoid	U937	9.2
Haematopoietic and lymphoid	UT7	8.7
Haematopoietic and lymphoid	WSUDLCL2	9.1
Kidney	769P	8.5
Kidney	786O	9.4
Kidney	A498	8.6
Kidney	A704	9
Kidney	ACHN	8.5
Kidney	BFTC909	8.6
Kidney	CAKI1	9.2
Kidney	CAKI2	9
Kidney	CAL54	8.5
Kidney	KMRC1	8
Kidney	KMRC20	8.9
Kidney	KMRC2	8.8
Kidney	KMRC3	9.1
Kidney	OSRC2	8.7
Kidney	RCC10RGB	9.2
Kidney	SNU1272	9.6
Kidney	SNU349	9.1
Kidney	TUHR10TKB	9.3
Kidney	TUHR14TKB	8.8
Kidney	TUHR4TKB	9.4
Kidney	VMRCRCW	9.1
Kidney	VMRCRCZ	9.5
Large intestine	C2BBE1	8.9
Large intestine	CCK81	8.9
Large intestine	CL11	8.9
Large intestine	CL14	8.5
Large intestine	CL34	8.8
Large intestine	CL40	8.6
Large intestine	COLO205	9.2
Large intestine	COLO320	8.9
Large intestine	COLO678	8.7
Large intestine	CW2	8.7
Large intestine	DLD1	8.9
Large intestine	GP2D	9.1
Large intestine	HCC56	9.4
Large intestine	HCT116	9.5
Large intestine	HCT15	8.9
Large intestine	HS675T	8.5
Large intestine	HS698T	8.2
Large intestine	HT115	8.9
Large intestine	HT29	9.1
Large intestine	HT55	8.4
Large intestine	KM12	9.2
Large intestine	LOVO	9.4
Large intestine	LS1034	9.3
Large intestine	LS123	8.6
Large intestine	LS180	8.7
Large intestine	LS411N	9.2
Large intestine	LS513	8.3
Large intestine	MDST8	8.6
Large intestine	NCIH508	9
Large intestine	NCIH716	8.5
Large intestine	NCIH747	9
Large intestine	OUMS23	8.9
Large intestine	RCM1	8.9
Large intestine	RKO	9.9
Large intestine	SKCO1	8
Large intestine	SNU1040	9
Large intestine	SNU1197	8.9
Large intestine	SNU175	8.8
Large intestine	SNU283	8.8
Large intestine	SNU407	9
Large intestine	SNU503	9.1
Large intestine	SNU61	8.9
Large intestine	SNU81	8.5
Large intestine	SNUC1	9.1
Large intestine	SNUC2A	8.8
Large intestine	SNUC4	9.4
Large intestine	SNUC5	9.2
Large intestine	SW1116	9.3
Large intestine	SW1417	9.6
Large intestine	SW1463	9.3
Large intestine	SW403	8.6
Large intestine	SW480	9.2
Large intestine	SW48	9.1
Large intestine	SW620	9.4
Large intestine	SW837	8.8
Large intestine	SW948	8.9
Large intestine	T84	8.7
Liver	ALEXANDERCELLS	8.3
Liver	C3A	9.1
Liver	HEP3B217	7.8
Liver	HEPG2	9.1
Liver	HLE	9.2
Liver	HLF	9.3
Liver	HUH1	8.7
Liver	HUH6	8.6
Liver	HUH7	9
Liver	JHH1	8.8
Liver	JHH2	9
Liver	JHH4	8.5
Liver	JHH5	8.9
Liver	JHH6	8.2
Liver	JHH7	9.2
Liver	LI7	9.5
Liver	PLCPRF5	8.9
Liver	SKHEP1	8.2
Liver	SNU182	9.4
Liver	SNU387	9.2
Liver	SNU398	9.4
Liver	SNU423	9.2
Liver	SNU449	8.7
Liver	SNU475	8.7
Liver	SNU761	8.3
Liver	SNU878	8
Liver	SNU886	8.8
Lung	A549	8.6
Lung	ABC1	8.6
Lung	BEN	8.1
Lung	CAL12T	8.7
Lung	CALU1	9.1
Lung	CALU3	8.8
Lung	CALU6	9
Lung	CHAGOK1	7.6
Lung	COLO668	7.9
Lung	COLO699	9.4
Lung	CORL105	9.1
Lung	CORL23	8.8
Lung	CORL24	8.6
Lung	CORL279	7.6
Lung	CORL311	7.4
Lung	CORL47	8.4
Lung	CORL51	7.3
Lung	CORL88	7.9
Lung	CORL95	7.9
Lung	CPCN	9.2
Lung	DMS114	9.5
Lung	DMS153	7.8
Lung	DMS273	9.5
Lung	DMS454	7.5
Lung	DMS53	9.2
Lung	DMS79	8.2
Lung	DV90	9.3
Lung	EBC1	9.6
Lung	EPLC272H	9.2
Lung	HARA	9.7
Lung	HCC1171	9.2
Lung	HCC1195	8.4
Lung	HCC15	8.9
Lung	HCC2279	9.4
Lung	HCC2935	8.6
Lung	HCC33	8.9
Lung	HCC366	7.7
Lung	HCC4006	8.3
Lung	HCC44	8
Lung	HCC78	8.9
Lung	HCC827	9.2
Lung	HCC95	8.8
Lung	HLC1	9.9
Lung	HLFA	8.6
Lung	HS229T	9.1
Lung	HS618T	8.8
Lung	IALM	9.6
Lung	KNS62	7.9
Lung	LC1F	9.6
Lung	LC1SQSF	9
Lung	LCLC103H	8.6
Lung	LCLC97TM1	8.9
Lung	LK2	9.3
Lung	LOUNH91	9.7
Lung	LU65	8.8
Lung	LU99	9.3
Lung	LUDLU1	8.9
Lung	LXF289	8.5
Lung	MORCPR	8.4
Lung	NCIH1048	9.1
Lung	NCIH1092	7.1
Lung	NCIH1105	7.4
Lung	NCIH1155	9.1
Lung	NCIH1184	8.3
Lung	NCIH1299	8.8
Lung	NCIH1339	8.8
Lung	NCIH1341	9.2
Lung	NCIH1355	8.3
Lung	NCIH1373	9.4
Lung	NCIH1385	8.6
Lung	NCIH1395	8.1
Lung	NCIH1435	7.9
Lung	NCIH1436	8
Lung	NCIH1437	8.2
Lung	NCIH146	8.5
Lung	NCIH1563	8.7
Lung	NCIH1568	8.1
Lung	NCIH1573	9.1
Lung	NCIH1581	8.5
Lung	NCIH1618	8.3
Lung	NCIH1623	8.5
Lung	NCIH1648	9.9
Lung	NCIH1650	8.4
Lung	NCIH1651	9.1
Lung	NCIH1666	9.9
Lung	NCIH1693	9.7
Lung	NCIH1694	8.8
Lung	NCIH1703	9.5
Lung	NCIH1734	8.6
Lung	NCIH1755	9
Lung	NCIH1781	8.6
Lung	NCIH1792	8.6
Lung	NCIH1793	9.1
Lung	NCIH1836	8.5
Lung	NCIH1838	8.6
Lung	NCIH1869	8.8
Lung	NCIH1876	8.2
Lung	NCIH1915	9.5
Lung	NCIH1930	8.7
Lung	NCIH1944	8.3
Lung	NCIH1963	8
Lung	NCIH196	8.3
Lung	NCIH1975	9.3
Lung	NCIH2009	8.6
Lung	NCIH2023	9.7
Lung	NCIH2029	9.5
Lung	NCIH2030	8.8
Lung	NCIH2066	9.3
Lung	NCIH2081	7.5
Lung	NCIH2085	9.6
Lung	NCIH2087	9.8
Lung	NCIH209	9.2
Lung	NCIH2106	8.9
Lung	NCIH2110	7
Lung	NCIH211	9.5
Lung	NCIH2122	8.6
Lung	NCIH2126	8.1
Lung	NCIH2141	7.9
Lung	NCIH2170	8.4
Lung	NCIH2171	8.1
Lung	NCIH2172	7.5
Lung	NCIH2196	8.8
Lung	NCIH2227	8.8
Lung	NCIH2228	9.3
Lung	NCIH226	9.4
Lung	NCIH2286	8.3
Lung	NCIH2291	8.5
Lung	NCIH2342	8.8
Lung	NCIH2347	9.2
Lung	NCIH23	9.1
Lung	NCIH2405	9.2
Lung	NCIH2444	9
Lung	NCIH292	7.9
Lung	NCIH322	8.8
Lung	NCIH3255	8.2
Lung	NCIH358	8.5
Lung	NCIH441	9.6
Lung	NCIH446	8.6
Lung	NCIH460	8.8
Lung	NCIH510	8.1
Lung	NCIH520	9.7
Lung	NCIH522	9
Lung	NCIH524	8.7
Lung	NCIH526	8.6
Lung	NCIH596	8.4
Lung	NCIH647	8.9
Lung	NCIH650	8.9
Lung	NCIH661	9.2
Lung	NCIH69	8.5
Lung	NCIH727	9.3
Lung	NCIH810	8.3
Lung	NCIH82	8.7
Lung	NCIH838	8.4
Lung	NCIH841	9.4
Lung	NCIH854	7.5
Lung	NCIH889	8
Lung	PC14	8.9
Lung	RERFLCAD1	8.7
Lung	RERFLCAD2	9
Lung	RERFLCAI	8.9
Lung	RERFLCKJ	8.9
Lung	RERFLCMS	9.1
Lung	RERFLCSQ1	9
Lung	SBC5	9.2
Lung	SCLC21H	8.7
Lung	SHP77	8.5
Lung	SKLU1	9
Lung	SKMES1	8.7
Lung	SQ1	9.1
Lung	SW1271	9.5
Lung	SW1573	9.1
Lung	SW900	7.9
Lung	VMRCLCD	8.7
Lung	VMRCLCP	9.1
Oesophagus	COLO680N	8.6
Oesophagus	ECGI10	8.6
Oesophagus	KYSE140	8.8
Oesophagus	KYSE150	8.8
Oesophagus	KYSE180	9.3
Oesophagus	KYSE270	8.4
Oesophagus	KYSE30	9.6
Oesophagus	KYSE410	9
Oesophagus	KYSE450	9.9
Oesophagus	KYSE510	9.3
Oesophagus	KYSE520	8.7
Oesophagus	KYSE70	8.5
Oesophagus	OE19	8.2
Oesophagus	OE33	8.5
Oesophagus	TE10	9
Oesophagus	TE11	9.1
Oesophagus	TE14	8.3
Oesophagus	TE15	9.1
Oesophagus	TE1	8.9
Oesophagus	TE4	8.5
Oesophagus	TE5	8.2
Oesophagus	TE6	9.2
Oesophagus	TE8	9.4
Oesophagus	TE9	8.9
Oesophagus	TT	9.3
Ovary	59M	8.6
Ovary	A2780	9
Ovary	CAOV3	9.3
Ovary	CAOV4	9.1
Ovary	COLO704	8.8
Ovary	COV318	8.5
Ovary	COV362	7.8
Ovary	COV434	7.8
Ovary	COV504	9
Ovary	COV644	8.4
Ovary	EFO21	9.1
Ovary	EFO27	9.7
Ovary	ES2	9
Ovary	FUOV1	9
Ovary	HEYA8	9
Ovary	HS571T	8.6
Ovary	IGROV1	8.9
Ovary	JHOC5	8.8
Ovary	JHOM1	8.7
Ovary	JHOM2B	8.5
Ovary	JHOS2	9.1
Ovary	JHOS4	9.2
Ovary	KURAMOCHI	9.1
Ovary	MCAS	9.1
Ovary	NIHOVCAR3	8.4
Ovary	OAW28	8.1
Ovary	OAW42	9.3
Ovary	OC314	9.1
Ovary	OC316	9
Ovary	ONCODG1	8.6
Ovary	OV56	7.9
Ovary	OV7	8.8
Ovary	OV90	8.9
Ovary	OVCAR4	9.4
Ovary	OVCAR8	8.7
Ovary	OVISE	9.1
Ovary	OVK18	8.9
Ovary	OVKATE	8.2
Ovary	OVMANA	8
Ovary	OVSAHO	9.3
Ovary	OVTOKO	9.2
Ovary	RMGI	8.6
Ovary	RMUGS	9.4
Ovary	SKOV3	9
Ovary	SNU119	8.9
Ovary	SNU840	9
Ovary	SNU8	8.8
Ovary	TOV112D	8.9
Ovary	TOV21G	9
Ovary	TYKNU	9.3
Pancreas	ASPC1	8.8
Pancreas	BXPC3	9.1
Pancreas	CAPAN1	8.7
Pancreas	CAPAN2	8.7
Pancreas	CFPAC1	8.8
Pancreas	DANG	8.7
Pancreas	HPAC	9
Pancreas	HPAFII	8.5
Pancreas	HS766T	9.4
Pancreas	HUPT3	9
Pancreas	HUPT4	8.7
Pancreas	KCIMOH1	8.8
Pancreas	KLM1	9.2
Pancreas	KP2	9.6
Pancreas	KP3	8.2
Pancreas	KP4	9.8
Pancreas	L33	8.8
Pancreas	MIAPACA2	10
Pancreas	PANC0203	9.3
Pancreas	PANC0213	8.3
Pancreas	PANC0327	9.3
Pancreas	PANC0403	8.1
Pancreas	PANC0504	9.2
Pancreas	PANC0813	8.7
Pancreas	PANC1005	9
Pancreas	PANC1	9.1
Pancreas	PATU8902	9.2
Pancreas	PATU8988S	9.1
Pancreas	PATU8988T	9.3
Pancreas	PK1	9.6
Pancreas	PK45H	8.5
Pancreas	PK59	8.3
Pancreas	PL45	9.3
Pancreas	PSN1	8.6
Pancreas	QGP1	9
Pancreas	SNU213	8.8
Pancreas	SNU324	9
Pancreas	SNU410	9.4
Pancreas	SU8686	8.4
Pancreas	SUIT2	7.8
Pancreas	SW1990	9.8
Pancreas	T3M4	8.5
Pancreas	TCCPAN2	8.7
Pancreas	YAPC	8.6
Pleura	ACCMESO1	10
Pleura	DM3	8.7
Pleura	ISTMES1	9.4
Pleura	ISTMES2	9.6
Pleura	JL1	9.2
Pleura	MPP89	9.1
Pleura	MSTO211H	9.3
Pleura	NCIH2052	9.4
Pleura	NCIH2452	9.3
Pleura	NCIH28	9.3
Prostate	22RV1	9.1
Prostate	DU145	9
Prostate	LNCAPCLONEFGC	8.7
Prostate	MDAPCA2B	9.3
Prostate	NCIH660	8.7
Prostate	PC3	8.5
Prostate	VCAP	8.6
Salivary gland	A253	8.1
Salivary gland	YD15	9.4
Skin	A101D	8.5
Skin	A2058	8.7
Skin	A375	9
Skin	C32	9.4
Skin	CHL1	8.9
Skin	CJM	9.3
Skin	COLO679	8.7
Skin	COLO741	7.6
Skin	COLO783	7.9
Skin	COLO792	7.9
Skin	COLO800	8.8
Skin	COLO818	8.3
Skin	COLO829	8.1
Skin	COLO849	8.6
Skin	G361	8.3
Skin	GRM	9.1
Skin	HMCB	9.2
Skin	HS294T	8.6
Skin	HS600T	8.6
Skin	HS688AT	8.9
Skin	HS695T	8.9
Skin	HS839T	8.6
Skin	HS852T	8.5
Skin	HS895T	8.9
Skin	HS934T	8.3
Skin	HS936T	9.1
Skin	HS939T	9
Skin	HS940T	8.8
Skin	HS944T	9
Skin	HT144	9
Skin	IGR1	8.7
Skin	IGR37	8.8
Skin	IGR39	9.6
Skin	IPC298	8.6
Skin	K029AX	8.9
Skin	LOXIMVI	8.5
Skin	MALME3M	7.5
Skin	MDAMB435S	7.7
Skin	MELHO	8.8
Skin	MELJUSO	9.2
Skin	MEWO	8.4
Skin	RPMI7951	7.8
Skin	RVH421	9.1
Skin	SH4	9.2
Skin	SKMEL1	9.1
Skin	SKMEL24	9.3
Skin	SKMEL28	8.9
Skin	SKMEL2	9.1
Skin	SKMEL30	9.1
Skin	SKMEL31	9.1
Skin	SKMEL3	9
Skin	SKMEL5	8.3
Skin	UACC257	8.5
Skin	UACC62	8.5
Skin	WM115	9
Skin	WM1799	8.1
Skin	WM2664	8.5
Skin	WM793	8.1
Skin	WM88	8.1
Skin	WM983B	8.4
Small intestine	HUTU80	9.2
Soft tissue	A204	9.4
Soft tissue	G401	9.2
Soft tissue	G402	9.4
Soft tissue	GCT	9.6
Soft tissue	HS729	9.3
Soft tissue	HT1080	9
Soft tissue	KYM1	8.6
Soft tissue	MESSA	8.6
Soft tissue	RD	8.7
Soft tissue	RH30	9.3
Soft tissue	RH41	8.8
Soft tissue	RKN	9.5
Soft tissue	S117	8.9
Soft tissue	SJRH30	9.6
Soft tissue	SKLMS1	9.2
Soft tissue	SKUT1	9.8
Soft tissue	TE125T	8.7
Soft tissue	TE159T	8.4
Soft tissue	TE441T	8.9
Soft tissue	TE617T	9
Stomach	2313287	8.5
Stomach	AGS	9.1
Stomach	AZ521	9.1
Stomach	ECC10	8.2
Stomach	ECC12	8.9
Stomach	FU97	8.4
Stomach	GCIY	8.9
Stomach	GSS	8.6
Stomach	GSU	8.3
Stomach	HGC27	9.1
Stomach	HS746T	8.9
Stomach	HUG1N	9
Stomach	IM95	8.8
Stomach	KATOIII	8.5
Stomach	KE39	8.4
Stomach	LMSU	9.2
Stomach	MKN1	9.2
Stomach	MKN45	8.8
Stomach	MKN74	9.1
Stomach	MKN7	8.9
Stomach	NCCSTCK140	7.6
Stomach	NCIN87	8.4
Stomach	NUGC2	9.7
Stomach	NUGC3	8.8
Stomach	NUGC4	8.7
Stomach	OCUM1	8.6
Stomach	RERFGC1B	9.1
Stomach	SH10TC	9.2
Stomach	SNU16	8.5
Stomach	SNU1	8.8
Stomach	SNU216	9
Stomach	SNU520	8.7
Stomach	SNU5	8.8
Stomach	SNU601	8.9
Stomach	SNU620	8.6
Stomach	SNU668	8.4
Stomach	SNU719	8.6
Stomach	TGBC11TKB	9.1
Thyroid	8305C	9.2
Thyroid	8505C	9.1
Thyroid	BCPAP	9.1
Thyroid	BHT101	8.5
Thyroid	CAL62	9.4
Thyroid	CGTHW1	9.5
Thyroid	FTC133	8.5
Thyroid	FTC238	9.3
Thyroid	ML1	9
Thyroid	SW579	8.7
Thyroid	TT2609C02	8.8
Thyroid	TT	8.2
Upper aerodigestive tract	BHY	8.7
Upper aerodigestive tract	BICR16	9.2
Upper aerodigestive tract	BICR18	9.3
Upper aerodigestive tract	BICR22	8.6
Upper aerodigestive tract	BICR31	7.6
Upper aerodigestive tract	BICR56	9.1
Upper aerodigestive tract	BICR6	8.9
Upper aerodigestive tract	CAL27	8.9
Upper aerodigestive tract	CAL33	8.6
Upper aerodigestive tract	DETROIT562	8.6
Upper aerodigestive tract	FADU	9.6
Upper aerodigestive tract	HS840T	8.8
Upper aerodigestive tract	HSC2	9.3
Upper aerodigestive tract	HSC3	9.5
Upper aerodigestive tract	HSC4	8.7
Upper aerodigestive tract	PECAPJ15	8.3
Upper aerodigestive tract	PECAPJ34CLONEC12	8.9
Upper aerodigestive tract	PECAPJ41CLONED2	8.6
Upper aerodigestive tract	PECAPJ49	9.2
Upper aerodigestive tract	SCC15	9.2
Upper aerodigestive tract	SCC25	8.7
Upper aerodigestive tract	SCC4	8.4
Upper aerodigestive tract	SCC9	8.6
Upper aerodigestive tract	SNU1076	8.2
Upper aerodigestive tract	SNU1214	9.1
Upper aerodigestive tract	SNU46	9.4
Upper aerodigestive tract	SNU899	8.7
Upper aerodigestive tract	YD10B	9.9
Upper aerodigestive tract	YD38	9.1
Upper aerodigestive tract	YD8	8.9
Urinary tract	5637	9.4
Urinary tract	639V	9.2
Urinary tract	647V	8.9
Urinary tract	BC3C	9
Urinary tract	BFTC905	9.2
Urinary tract	CAL29	9
Urinary tract	HS172T	8.3
Urinary tract	HT1197	7.6
Urinary tract	HT1376	8.8
Urinary tract	J82	9.2
Urinary tract	JMSU1	9.3
Urinary tract	KMBC2	8.8
Urinary tract	KU1919	8.9
Urinary tract	RT11284	8.5
Urinary tract	RT112	9.3
Urinary tract	RT4	9.5
Urinary tract	SCABER	8.8
Urinary tract	SW1710	9.2
Urinary tract	SW780	9.2
Urinary tract	T24	9.3
Urinary tract	TCCSUP	8.6
Urinary tract	UMUC1	8.9
Urinary tract	UMUC3	9.6
Urinary tract	VMCUB1	8.6

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	19.6
Adrenal gland	37.6
Appendix	30.2
Bone marrow	21.9
Breast	30
Cerebral cortex	22.5
Cervix, uterine	32.7
Colon	22.7
Duodenum	18.6
Endometrium	33.5
Epididymis	29.6
Esophagus	30.3
Fallopian tube	41.7
Gallbladder	30.7
Heart muscle	16.5
Kidney	24.9
Liver	19.8
Lung	30.7
Lymph node	35.8
Ovary	30.7
Pancreas	5.8
Parathyroid gland	51.1
Placenta	30.5
Prostate	33
Rectum	25.9
Salivary gland	9.4
Seminal vesicle	29.2
Skeletal muscle	10.9
Skin	37.6
Small intestine	21.3
Smooth muscle	36.1
Spleen	29
Stomach	18
Testis	28.4
Thyroid gland	39
Tonsil	38.2
Urinary bladder	28

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
20049841	Overexpression	Ovarian Carcinoma	The results indicated that the immunohistochemical expression of nuclear HDAC1, HDAC2 and HDAC3 proteins increased stepwise in benign, borderline and malignant tumors.
20636436	Overexpression	Acute Lymphoblastic Leukemia	ALL samples showed higher expression levels of HDAC2, HDAC3, HDAC8, HDAC6 and HDAC7 when compared to normal bone marrow samples.
21143702	Underexpression	Glioma	HDAC3 expression was inversely associated with tumor grade. Consequently, increased HDAC3 expression was associated with better patient survival in univariate regression.
21206745	Overexpression	Hepatocellular Carcinoma	Class I HDACs were highly expressed in a subset of HCCs with positivity for HDAC1 in 51.2%, HDAC2 in 48.8%, and HDAC3 in 32.6% of cases.
27522258	Overexpression	Leukemia	Here, we found that HDAC3 is up-regulated in clinical samples of leukemia compared with adjacent normal tissues.
25070540	Overexpression	Pancreatic Carcinoma	Consistently, higher expression level of HDAC3 was found in all of the eight pancreatic cancer cell lines relative to human pancreatic ductal epithelial cells (HPDE).
22270866	Overexpression	Colorectal Carcinoma	The immunohistochemical staining of HDACs, including HDAC1, HDAC2, HDAC3, and HDAC4, was significantly increased in colorectal adenocarcinoma specimens compared to healthy control tissues.
23685192	Overexpression	Glioma	Data showed that HDAC3 was significantly elevated in children's gliomas, following the glioma grade, with almost no expression in normal brain tissues.
20563766	Overexpression	Lung Adenocarcinoma	The 5-year disease-free survival (5-DFS) rate among patients expressing high levels of HDAC3 was significantly poorer than among those expressing lower levels (P = 0.005; log-rank test).
23627572	Overexpression	Breast Carcinoma	HDAC2 and HDAC3 are strongly expressed in subgroups of tumor with features of a more aggressive tumor type.
23724067	Overexpression	Colorectal Carcinoma	We found HDAC1, HDAC2, HDAC3, HDAC5, and HDAC7 all to be up-regulated in the field of human CRC.
24441677	Overexpression	Lung Carcinoma	Finally, immunohistochemistry on human lung cancer specimens revealed a significant increase in DNMT1, HDAC1, HDAC2, and HDAC3 expression, supporting our hypotheses that class I HDACs are mediators of DNMT1 stability.
25791281	Overexpression	Glioma	Among all patients studied, the expression of HDAC1 and HDAC3 was inversely correlated with survival, whereas the expression of HDAC4, HDAC5, HDAC6, HDAC11 and SIRT1 was significantly and positively correlated with survival time of patients with gliomas.
28569784	Overexpression	Cholangiocarcinoma	Immunochemistry showed that HDAC3 was upregulated in CCA tissues compared with adjacent normal tissues, and this was correlated with reduced patient survival.

Summary
Symbol	HDAC3
Name	histone deacetylase 3
Aliases	HD3; RPD3-2; SMAP45
Location	5q31.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.544	1.62e-32	46.3	46.8	6.9	Loss
BRCA	Breast invasive carcinoma	1075	0.492	1.32e-66	21.6	57.6	20.8	Neutral
CESC	Cervical and endocervical cancers	292	0.498	9.95e-20	21.9	67.5	10.6	Neutral
COAD	Colon adenocarcinoma	449	0.472	2.42e-26	19.8	72.2	8	Neutral
ESCA	Esophageal carcinoma	183	0.6	2.97e-19	49.2	44.8	6	Loss
GBM	Glioblastoma multiforme	147	0.543	1.23e-12	12.9	79.6	7.5	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.598	3.1e-51	38.3	55.1	6.6	Loss
KIRC	Kidney renal clear cell carcinoma	525	0.493	1.85e-33	0.6	38.7	60.8	Gain
KIRP	Kidney renal papillary cell carcinoma	288	0.434	1.1e-14	3.8	83.7	12.5	Neutral
LAML	Acute Myeloid Leukemia	166	0.553	1.16e-14	9	91	0	Neutral
LGG	Brain Lower Grade Glioma	513	0.268	7.35e-10	9.4	89.1	1.6	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.513	8.87e-26	11.5	56.6	31.9	Neutral
LUAD	Lung adenocarcinoma	512	0.642	7.9e-61	36.9	45.3	17.8	Loss
LUSC	Lung squamous cell carcinoma	498	0.449	4.32e-26	74.1	22.1	3.8	Loss
OV	Ovarian serous cystadenocarcinoma	300	0.65	2.39e-37	40.7	42.3	17	Loss
PAAD	Pancreatic adenocarcinoma	177	0.398	3.97e-08	10.7	78	11.3	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.459	8.22e-10	7.4	87.7	4.9	Neutral
PRAD	Prostate adenocarcinoma	491	0.388	4.43e-19	5.5	90	4.5	Neutral
READ	Rectum adenocarcinoma	164	0.603	1.26e-17	28	59.8	12.2	Neutral
SARC	Sarcoma	255	0.481	3.7e-16	14.9	59.2	25.9	Neutral
SKCM	Skin Cutaneous Melanoma	367	0.643	3.49e-44	35.7	54.5	9.8	Loss
STAD	Stomach adenocarcinoma	413	0.501	1.39e-27	30.8	63.2	6.1	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.409	1.98e-07	65.3	32	2.7	Loss
THCA	Thyroid carcinoma	497	0.364	4.92e-17	0	96.2	3.8	Neutral
THYM	Thymoma	119	0.143	0.121	0.8	91.6	7.6	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.176	4e-05	15.1	80.1	4.8	Neutral

Summary
Symbol	HDAC3
Name	histone deacetylase 3
Aliases	HD3; RPD3-2; SMAP45
Location	5q31.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.244	4.07e-07	17	408	0	0.778	NS/NA
BRCA	Breast invasive carcinoma	-0.118	0.000514	83	785	0.002	0.00804	NS/NA
CESC	Cervical and endocervical cancers	-0.174	0.00214	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.107	0.0567	19	297	0.002	0.0606	NS/NA
ESCA	Esophageal carcinoma	-0.228	0.00144	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.335	0.00668	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.065	0.132	20	522	0.001	0.0147	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.141	0.00877	24	319	0	0.12	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.109	0.0602	23	275	0.001	0.769	NS/NA
LAML	Acute Myeloid Leukemia	-0.297	8.91e-05	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.244	1.32e-08	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.163	0.000857	41	373	-0.002	0.238	NS/NA
LUAD	Lung adenocarcinoma	-0.077	0.0947	21	456	-0.002	0.934	NS/NA
LUSC	Lung squamous cell carcinoma	-0.17	0.000889	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.833	0.00827	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.241	0.00104	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.261	0.000314	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.222	2.3e-07	35	498	-0.01	4.38e-05	NS/NA
READ	Rectum adenocarcinoma	-0.294	0.00291	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.267	1.26e-05	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.281	6.27e-10	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.077	0.14	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.38	1.2e-06	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.008	0.844	50	509	-0.001	0.169	NS/NA
THYM	Thymoma	-0.114	0.211	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	0.058	0.209	34	431	-0.001	0.107	NS/NA

Summary
Symbol	HDAC3
Name	histone deacetylase 3
Aliases	HD3; RPD3-2; SMAP45
Location	5q31.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	2	Medium
Appendix	2	Medium
Bone marrow	1	Low
Breast	2	Medium
Bronchus	1	Low
Caudate	2	Medium
Cerebellum	3	High
Cerebral cortex	3	High
Cervix, uterine	2	Medium
Colon	2	Medium
Duodenum	2	Medium
Endometrium	2	Medium
Epididymis	3	High
Esophagus	3	High
Fallopian tube	2	Medium
Gallbladder	2	Medium
Heart muscle	2	Medium
Hippocampus	2	Medium
Kidney	2	Medium
Liver	0	Not detected
Lung	1	Low
Lymph node	2	Medium
Nasopharynx	1	Low
Oral mucosa	2	Medium
Ovary	1	Low
Pancreas	2	Medium
Parathyroid gland	1	Low
Placenta	2	Medium
Prostate	2	Medium
Rectum	2	Medium
Salivary gland	1	Low
Seminal vesicle	2	Medium
Skeletal muscle	1	Low
Skin	2	Medium
Small intestine	2	Medium
Smooth muscle	2	Medium
Soft tissue	2	Medium
Spleen	1	Low
Stomach	2	Medium
Testis	2	Medium
Thyroid gland	2	Medium
Tonsil	2	Medium
Urinary bladder	3	High
Vagina	2	Medium

Summary
Symbol	HDAC3
Name	histone deacetylase 3
Aliases	HD3; RPD3-2; SMAP45
Location	5q31.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.146	NS	24476821
BRCA	Breast invasive carcinoma	521	0.0387	Significant	23000897
COAD	Colon adenocarcinoma	149	0.504	NS	22810696
GBM	Glioblastoma multiforme	157	0.0932	NS	26824661
HNSC	Head and Neck squamous cell carcinoma	279	0.00294	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	1.51e-07	Significant	26536169
LGG	Brain Lower Grade Glioma	513	1.14e-24	Significant	26824661
LUAD	Lung adenocarcinoma	230	0.655	NS	25079552
LUSC	Lung squamous cell carcinoma	178	0.282	NS	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.0146	Significant	21720365
PRAD	Prostate adenocarcinoma	333	0.0237	Significant	26544944
READ	Rectum adenocarcinoma	67	0.38	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.0563	NS	26091043
STAD	Stomach adenocarcinoma	277	1.75e-12	Significant	25079317
THCA	Thyroid carcinoma	391	6.48e-07	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.00353	Significant	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	1.078	0.721	NS
BRCA	Breast invasive carcinoma	1079	1.373	0.156	NS
CESC	Cervical and endocervical cancers	291	1.6	0.175	NS
COAD	Colon adenocarcinoma	439	0.504	0.0145	Longer
ESCA	Esophageal carcinoma	184	0.884	0.716	NS
GBM	Glioblastoma multiforme	158	1.234	0.416	NS
HNSC	Head and Neck squamous cell carcinoma	518	1.48	0.0422	Shorter
KIRC	Kidney renal clear cell carcinoma	531	0.941	0.787	NS
KIRP	Kidney renal papillary cell carcinoma	287	1.001	0.998	NS
LAML	Acute Myeloid Leukemia	149	1.276	0.387	NS
LGG	Brain Lower Grade Glioma	511	2.275	0.000741	Shorter
LIHC	Liver hepatocellular carcinoma	365	1.097	0.717	NS
LUAD	Lung adenocarcinoma	502	0.846	0.44	NS
LUSC	Lung squamous cell carcinoma	494	0.962	0.843	NS
OV	Ovarian serous cystadenocarcinoma	303	1.005	0.982	NS
PAAD	Pancreatic adenocarcinoma	177	0.563	0.0408	Longer
PCPG	Pheochromocytoma and Paraganglioma	179	0.975	0.98	NS
PRAD	Prostate adenocarcinoma	497	0	0.379	NS
READ	Rectum adenocarcinoma	159	0.391	0.136	NS
SARC	Sarcoma	259	1.063	0.832	NS
SKCM	Skin Cutaneous Melanoma	459	1.402	0.0775	NS
STAD	Stomach adenocarcinoma	388	0.781	0.276	NS
TGCT	Testicular Germ Cell Tumors	134	1	1	NS
THCA	Thyroid carcinoma	500	2.037	0.247	NS
THYM	Thymoma	119	0.483	0.543	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	1.319	0.401	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	-0.094	0.0597	NS
BRCA	Breast invasive carcinoma	1071	0.006	0.84	NS
CESC	Cervical and endocervical cancers	167	0.146	0.0597	NS
COAD	Colon adenocarcinoma	445	-0.064	0.18	NS
ESCA	Esophageal carcinoma	162	-0.014	0.856	NS
HNSC	Head and Neck squamous cell carcinoma	448	0.043	0.36	NS
KIRC	Kidney renal clear cell carcinoma	531	0.021	0.634	NS
KIRP	Kidney renal papillary cell carcinoma	260	0.16	0.00962	Higher
LIHC	Liver hepatocellular carcinoma	347	-0.084	0.118	NS
LUAD	Lung adenocarcinoma	507	0.008	0.858	NS
LUSC	Lung squamous cell carcinoma	497	-0.028	0.532	NS
OV	Ovarian serous cystadenocarcinoma	302	0	0.996	NS
PAAD	Pancreatic adenocarcinoma	176	-0.155	0.0395	Lower
READ	Rectum adenocarcinoma	156	-0.084	0.299	NS
SKCM	Skin Cutaneous Melanoma	410	-0.029	0.562	NS
STAD	Stomach adenocarcinoma	392	-0.019	0.707	NS
TGCT	Testicular Germ Cell Tumors	81	0.442	3.56e-05	Higher
THCA	Thyroid carcinoma	499	0.087	0.0524	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.051	0.252	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	-0.011	0.862	NS
HNSC	Head and Neck squamous cell carcinoma	498	-0.028	0.531	NS
KIRC	Kidney renal clear cell carcinoma	525	0.078	0.0758	NS
LGG	Brain Lower Grade Glioma	514	0.215	8.23e-07	Higher
LIHC	Liver hepatocellular carcinoma	366	0.014	0.792	NS
OV	Ovarian serous cystadenocarcinoma	296	0.043	0.463	NS
PAAD	Pancreatic adenocarcinoma	176	-0.053	0.482	NS
STAD	Stomach adenocarcinoma	406	0.104	0.0362	Higher
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.334	2.26e-15	Higher

Summary
Symbol	HDAC3
Name	histone deacetylase 3
Aliases	HD3; RPD3-2; SMAP45
Location	5q31.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	HDAC3
Name	histone deacetylase 3
Aliases	HD3; RPD3-2; SMAP45
Location	5q31.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database

[ TOP ]

DrugBank ID	Name	Type
DB02546	Vorinostat	Small Molecule Drug
DB05223	SB939	Small Molecule Drug
DB05651	MGCD-0103	Small Molecule Drug
DB05015	Belinostat	Small Molecule Drug
DB06603	Panobinostat	Small Molecule Drug
DB02546	Vorinostat	Small Molecule Drug
DB05223	SB939	Small Molecule Drug
DB05651	MGCD-0103	Small Molecule Drug
DB05015	Belinostat	Small Molecule Drug
DB06603	Panobinostat	Small Molecule Drug

Summary
Symbol	HDAC3
Name	histone deacetylase 3
Aliases	HD3; RPD3-2; SMAP45
Location	5q31.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]
There is no record for HDAC3.

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
20049841	Ovarian Carcinoma	partner	E-cadherin	Negative Correlation	The expression of HDAC1 and HDAC2 was correlated with Ki-67 expression and that of HDAC3 was inversely correlated with E-cadherin expression.