CR2Cancer

Summary
Symbol	HDAC5
Name	histone deacetylase 5
Aliases	KIAA0600; NY-CO-9; FLJ90614; HD5; antigen NY-CO-9
Location	17q21.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

[ TOP ]

Domain

PF12203 Glutamine rich N terminal domain of histone deacetylase 4
PF00850 Histone deacetylase domain

Function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification erase	Histone acetylation	H2AKac, H2BKac, H3Kac, H4Kac	H2AK, H2BK, H3K, H4K	10220385

> Gene Ontology [ TOP ]
Biological Process	GO:0001525 angiogenesis GO:0001667 ameboidal-type cell migration GO:0002040 sprouting angiogenesis GO:0002042 cell migration involved in sprouting angiogenesis GO:0002237 response to molecule of bacterial origin GO:0002521 leukocyte differentiation GO:0006338 chromatin remodeling GO:0006342 chromatin silencing GO:0006476 protein deacetylation GO:0010594 regulation of endothelial cell migration GO:0010596 negative regulation of endothelial cell migration GO:0010631 epithelial cell migration GO:0010632 regulation of epithelial cell migration GO:0010633 negative regulation of epithelial cell migration GO:0010830 regulation of myotube differentiation GO:0010832 negative regulation of myotube differentiation GO:0014823 response to activity GO:0014902 myotube differentiation GO:0016458 gene silencing GO:0016525 negative regulation of angiogenesis GO:0016570 histone modification GO:0016575 histone deacetylation GO:0030098 lymphocyte differentiation GO:0030183 B cell differentiation GO:0030336 negative regulation of cell migration GO:0032496 response to lipopolysaccharide GO:0032868 response to insulin GO:0032869 cellular response to insulin stimulus GO:0035601 protein deacylation GO:0040013 negative regulation of locomotion GO:0040029 regulation of gene expression, epigenetic GO:0042113 B cell activation GO:0042220 response to cocaine GO:0042493 response to drug GO:0042692 muscle cell differentiation GO:0043279 response to alkaloid GO:0043393 regulation of protein binding GO:0043434 response to peptide hormone GO:0043534 blood vessel endothelial cell migration GO:0043535 regulation of blood vessel endothelial cell migration GO:0043537 negative regulation of blood vessel endothelial cell migration GO:0043542 endothelial cell migration GO:0045765 regulation of angiogenesis GO:0045814 negative regulation of gene expression, epigenetic GO:0048514 blood vessel morphogenesis GO:0051090 regulation of sequence-specific DNA binding transcription factor activity GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051098 regulation of binding GO:0051146 striated muscle cell differentiation GO:0051147 regulation of muscle cell differentiation GO:0051148 negative regulation of muscle cell differentiation GO:0051153 regulation of striated muscle cell differentiation GO:0051154 negative regulation of striated muscle cell differentiation GO:0051271 negative regulation of cellular component movement GO:0070932 histone H3 deacetylation GO:0071216 cellular response to biotic stimulus GO:0071219 cellular response to molecule of bacterial origin GO:0071222 cellular response to lipopolysaccharide GO:0071375 cellular response to peptide hormone stimulus GO:0071396 cellular response to lipid GO:0071417 cellular response to organonitrogen compound GO:0090049 regulation of cell migration involved in sprouting angiogenesis GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis GO:0090130 tissue migration GO:0090132 epithelium migration GO:0098732 macromolecule deacylation GO:1901342 regulation of vasculature development GO:1901343 negative regulation of vasculature development GO:1901652 response to peptide GO:1901653 cellular response to peptide GO:1903670 regulation of sprouting angiogenesis GO:1903671 negative regulation of sprouting angiogenesis GO:2000146 negative regulation of cell motility GO:2000181 negative regulation of blood vessel morphogenesis
Molecular Function	GO:0001025 RNA polymerase III transcription factor binding GO:0001047 core promoter binding GO:0003682 chromatin binding GO:0004407 histone deacetylase activity GO:0005080 protein kinase C binding GO:0008134 transcription factor binding GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides GO:0017136 NAD-dependent histone deacetylase activity GO:0019213 deacetylase activity GO:0031078 histone deacetylase activity (H3-K14 specific) GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific) GO:0033558 protein deacetylase activity GO:0034979 NAD-dependent protein deacetylase activity GO:0042826 histone deacetylase binding GO:0070491 repressing transcription factor binding
Cellular Component	GO:0000118 histone deacetylase complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-2894862: Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2644606: Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-1643685: Disease R-HSA-5663202: Diseases of signal transduction R-HSA-2122947: NOTCH1 Intracellular Domain Regulates Transcription R-HSA-162582: Signal Transduction R-HSA-157118: Signaling by NOTCH R-HSA-1980143: Signaling by NOTCH1 R-HSA-2894858: Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2644602: Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644603: Signaling by NOTCH1 in Cancer

> KEGG and Reactome Pathway

[ TOP ]

KEGG

Reactome

R-HSA-2894862: Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
R-HSA-2644606: Constitutive Signaling by NOTCH1 PEST Domain Mutants
R-HSA-1643685: Disease
R-HSA-5663202: Diseases of signal transduction
R-HSA-2122947: NOTCH1 Intracellular Domain Regulates Transcription
R-HSA-162582: Signal Transduction
R-HSA-157118: Signaling by NOTCH
R-HSA-1980143: Signaling by NOTCH1
R-HSA-2894858: Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
R-HSA-2644602: Signaling by NOTCH1 PEST Domain Mutants in Cancer
R-HSA-2644603: Signaling by NOTCH1 in Cancer

Summary
Symbol	HDAC5
Name	histone deacetylase 5
Aliases	KIAA0600; NY-CO-9; FLJ90614; HD5; antigen NY-CO-9
Location	17q21.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM1383594	c.2793delC	p.I932fs*14	Deletion - Frameshift	Large_intestine
COSM3190622	c.1418C>T	p.T473M	Substitution - Missense	Stomach
COSM3736164	c.1779C>G	p.D593E	Substitution - Missense	Thyroid
COSM215691	c.2093G>A	p.C698Y	Substitution - Missense	Central_nervous_system
COSM5029383	c.2286A>G	p.L762L	Substitution - coding silent	Bone
COSM1679859	c.3263C>T	p.A1088V	Substitution - Missense	Large_intestine
COSM3190644	c.91A>G	p.T31A	Substitution - Missense	Large_intestine
COSM3517986	c.1603C>T	p.L535F	Substitution - Missense	Skin
COSM979881	c.178C>T	p.R60W	Substitution - Missense	Kidney
COSM4066855	c.2189T>A	p.I730N	Substitution - Missense	Stomach
COSM3712507	c.2327A>G	p.Y776C	Substitution - Missense	Upper_aerodigestive_tract
COSM3730023	c.2793_2794insC	p.I932fs*24	Insertion - Frameshift	Large_intestine
COSM3819725	c.468G>A	p.E156E	Substitution - coding silent	Breast
COSM1383596	c.2594T>C	p.L865P	Substitution - Missense	Large_intestine
COSM231373	c.1328C>T	p.S443F	Substitution - Missense	Skin
COSM979869	c.1444C>T	p.R482W	Substitution - Missense	Endometrium
COSM5954657	c.2107G>A	p.V703M	Substitution - Missense	Upper_aerodigestive_tract
COSM1383603	c.924G>A	p.S308S	Substitution - coding silent	Large_intestine
COSM3970090	c.850C>T	p.R284C	Substitution - Missense	Central_nervous_system
COSM1710355	c.1789G>A	p.E597K	Substitution - Missense	Skin
COSM3190632	c.1003A>T	p.T335S	Substitution - Missense	Large_intestine
COSM1679859	c.3263C>T	p.A1088V	Substitution - Missense	Large_intestine
COSM71029	c.1747C>G	p.Q583E	Substitution - Missense	Ovary
COSM5004974	c.797G>A	p.R266H	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1163157	c.3183G>A	p.V1061V	Substitution - coding silent	Pancreas
COSM3736164	c.1779C>G	p.D593E	Substitution - Missense	Breast
COSM4951787	c.240C>G	p.L80L	Substitution - coding silent	Liver
COSM979867	c.1479G>A	p.L493L	Substitution - coding silent	Endometrium
COSM5972212	c.3365T>C	p.L1122P	Substitution - Missense	Upper_aerodigestive_tract
COSM1302877	c.1402C>T	p.Q468*	Substitution - Nonsense	Urinary_tract
COSM3190633	c.928G>A	p.V310M	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5951053	c.1975A>T	p.T659S	Substitution - Missense	Prostate
COSM1610313	c.1448C>T	p.T483M	Substitution - Missense	Liver
COSM3517984	c.3007G>A	p.E1003K	Substitution - Missense	Skin
COSM3730023	c.2793_2794insC	p.I932fs*24	Insertion - Frameshift	Large_intestine
COSM4387144	c.1918C>T	p.Q640*	Substitution - Nonsense	Lung
COSM3517985	c.2287G>C	p.D763H	Substitution - Missense	Skin
COSM5741008	c.3330-1G>T	p.?	Unknown	Small_intestine
COSM3819723	c.2375G>A	p.W792*	Substitution - Nonsense	Breast
COSM5741010	c.376G>A	p.A126T	Substitution - Missense	Small_intestine
COSM4623570	c.1433C>T	p.A478V	Substitution - Missense	Large_intestine
COSM1679859	c.3263C>T	p.A1088V	Substitution - Missense	Large_intestine
COSM4066861	c.214C>T	p.R72W	Substitution - Missense	Stomach
COSM4066859	c.899T>C	p.I300T	Substitution - Missense	Stomach
COSM4483115	c.2672C>T	p.S891F	Substitution - Missense	Skin
COSM4066852	c.3179G>A	p.C1060Y	Substitution - Missense	Stomach
COSM4689687	c.1398delC	p.H466fs*6	Deletion - Frameshift	Large_intestine
COSM979861	c.2142C>A	p.I714I	Substitution - coding silent	Endometrium
COSM4414644	c.2546C>G	p.A849G	Substitution - Missense	Kidney
COSM4579744	c.2315G>A	p.S772N	Substitution - Missense	Bone
COSM5484112	c.160C>T	p.P54S	Substitution - Missense	Large_intestine
COSM5556600	c.1398C>T	p.H466H	Substitution - coding silent	Prostate
COSM242539	c.850C>A	p.R284S	Substitution - Missense	Prostate
COSM3686130	c.1165-3delC	p.?	Unknown	Large_intestine
COSM4689690	c.165C>T	p.S55S	Substitution - coding silent	Large_intestine
COSM4539905	c.2750G>A	p.G917E	Substitution - Missense	Skin
COSM5363996	c.2405G>A	p.R802H	Substitution - Missense	Large_intestine
COSM5631818	c.2217G>A	p.E739E	Substitution - coding silent	Oesophagus
COSM3190619	c.1465C>T	p.R489W	Substitution - Missense	Large_intestine
COSM4790486	c.1638C>A	p.T546T	Substitution - coding silent	Liver
COSM5686527	c.1973G>T	p.R658L	Substitution - Missense	Soft_tissue
COSM4066860	c.654T>C	p.H218H	Substitution - coding silent	Stomach
COSM6002734	c.1152C>G	p.N384K	Substitution - Missense	Prostate
COSM1325044	c.51G>A	p.L17L	Substitution - coding silent	Ovary
COSM1383605	c.370C>T	p.L124L	Substitution - coding silent	Large_intestine
COSM4753673	c.2746G>A	p.V916M	Substitution - Missense	Stomach
COSM979855	c.2639C>T	p.A880V	Substitution - Missense	Endometrium
COSM244870	c.1013T>A	p.V338D	Substitution - Missense	Prostate
COSM4689686	c.2208G>A	p.T736T	Substitution - coding silent	Large_intestine
COSM5807898	c.3027C>T	p.T1009T	Substitution - coding silent	Liver
COSM4777071	c.2375G>T	p.W792L	Substitution - Missense	Breast
COSM1383601	c.1722G>T	p.E574D	Substitution - Missense	Large_intestine
COSM355091	c.1074C>T	p.P358P	Substitution - coding silent	Lung
COSM1610313	c.1448C>T	p.T483M	Substitution - Missense	Liver
COSM3517987	c.695C>T	p.P232L	Substitution - Missense	Skin
COSM979863	c.2129G>A	p.R710Q	Substitution - Missense	Endometrium
COSM3989054	c.2686G>T	p.D896Y	Substitution - Missense	Kidney
COSM5921163	c.2607+4G>A	p.?	Unknown	Skin
COSM4623570	c.1433C>T	p.A478V	Substitution - Missense	Large_intestine
COSM979875	c.604G>A	p.G202S	Substitution - Missense	Endometrium
COSM979853	c.2727+1G>A	p.?	Unknown	Endometrium
COSM4066853	c.2610C>T	p.D870D	Substitution - coding silent	Stomach
COSM4066854	c.2309C>A	p.P770H	Substitution - Missense	Stomach
COSM3190584	c.3310G>A	p.A1104T	Substitution - Missense	Lung
COSM979857	c.2501C>T	p.A834V	Substitution - Missense	Endometrium
COSM979873	c.927C>T	p.S309S	Substitution - coding silent	Endometrium
COSM5513314	c.3250G>A	p.E1084K	Substitution - Missense	Biliary_tract
COSM4488274	c.3297C>A	p.A1099A	Substitution - coding silent	Skin
COSM3730023	c.2793_2794insC	p.I932fs*24	Insertion - Frameshift	Breast
COSM3190595	c.3068T>G	p.L1023R	Substitution - Missense	Large_intestine
COSM5364279	c.2646C>T	p.Y882Y	Substitution - coding silent	Large_intestine
COSM3730023	c.2793_2794insC	p.I932fs*24	Insertion - Frameshift	Stomach
COSM4506046	c.706C>T	p.P236S	Substitution - Missense	Skin
COSM1383602	c.1696_1697insG	p.E566fs*15	Insertion - Frameshift	Large_intestine
COSM5772129	c.2271C>T	p.L757L	Substitution - coding silent	Breast
COSM4646549	c.1329C>A	p.S443S	Substitution - coding silent	Large_intestine
COSM979865	c.1686C>A	p.V562V	Substitution - coding silent	Endometrium
COSM3819724	c.481G>A	p.E161K	Substitution - Missense	Breast
COSM4066856	c.2177A>C	p.K726T	Substitution - Missense	Stomach
COSM436683	c.622C>T	p.P208S	Substitution - Missense	Breast
COSM1479623	c.1265C>T	p.S422F	Substitution - Missense	Breast
COSM5470681	c.1973G>A	p.R658H	Substitution - Missense	Large_intestine
COSM187579	c.3127G>A	p.A1043T	Substitution - Missense	Large_intestine
COSM1383598	c.1838C>T	p.A613V	Substitution - Missense	Large_intestine
COSM3517982	c.3316G>A	p.E1106K	Substitution - Missense	Skin
COSM5620938	c.1343T>C	p.V448A	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM979855	c.2639C>T	p.A880V	Substitution - Missense	Breast
COSM4995747	c.16G>T	p.E6*	Substitution - Nonsense	Upper_aerodigestive_tract
COSM5963026	c.2680C>T	p.R894C	Substitution - Missense	Breast
COSM5434093	c.2345G>A	p.G782E	Substitution - Missense	Oesophagus
COSM5363996	c.2405G>A	p.R802H	Substitution - Missense	Large_intestine
COSM5618277	c.578C>T	p.S193L	Substitution - Missense	Breast
COSM1383593	c.3132G>A	p.V1044V	Substitution - coding silent	Large_intestine
COSM3370750	c.675C>T	p.S225S	Substitution - coding silent	Thyroid
COSM5566755	c.2198G>A	p.R733H	Substitution - Missense	Prostate
COSM4976639	c.1049G>A	p.R350Q	Substitution - Missense	Oesophagus
COSM1209387	c.1427G>A	p.R476H	Substitution - Missense	Large_intestine
COSM4881256	c.3G>A	p.M1I	Substitution - Missense	Upper_aerodigestive_tract
COSM4689689	c.249C>T	p.L83L	Substitution - coding silent	Large_intestine
COSM4840053	c.2557A>G	p.K853E	Substitution - Missense	Cervix
COSM5432001	c.439_456del18	p.R147_Q152delREQQRQ	Deletion - In frame	Oesophagus
COSM5628625	c.3261C>T	p.S1087S	Substitution - coding silent	Oesophagus
COSM979851	c.2796T>C	p.I932I	Substitution - coding silent	Endometrium
COSM5018425	c.2018delC	p.P673fs*20	Deletion - Frameshift	Soft_tissue
COSM4066858	c.1650G>T	p.E550D	Substitution - Missense	Stomach
COSM5443694	c.1345C>A	p.L449M	Substitution - Missense	Oesophagus
COSM4429169	c.2970G>A	p.L990L	Substitution - coding silent	Oesophagus
COSM1383597	c.1871C>A	p.A624D	Substitution - Missense	Large_intestine
COSM4689688	c.689G>C	p.G230A	Substitution - Missense	Large_intestine
COSM4840120	c.284T>C	p.F95S	Substitution - Missense	Cervix
COSM1209385	c.2935A>G	p.T979A	Substitution - Missense	Large_intestine
COSM5554619	c.34G>C	p.G12R	Substitution - Missense	Prostate
COSM3190625	c.1182G>A	p.S394S	Substitution - coding silent	Large_intestine
COSM3190637	c.689G>A	p.G230D	Substitution - Missense	Large_intestine
COSM5513315	c.2500G>A	p.A834T	Substitution - Missense	Biliary_tract
COSM1383594	c.2793delC	p.I932fs*14	Deletion - Frameshift	Large_intestine
COSM5775314	c.3013G>C	p.G1005R	Substitution - Missense	Breast
COSM1163158	c.1717_1718insC	p.R573fs*8	Insertion - Frameshift	Pancreas
COSM3736164	c.1779C>G	p.D593E	Substitution - Missense	Large_intestine
COSM4951787	c.240C>G	p.L80L	Substitution - coding silent	Liver
COSM3190624	c.1224G>T	p.R408R	Substitution - coding silent	Large_intestine
COSM4884158	c.37C>T	p.R13W	Substitution - Missense	Upper_aerodigestive_tract
COSM4468069	c.1521C>T	p.A507A	Substitution - coding silent	Skin
COSM979863	c.2129G>A	p.R710Q	Substitution - Missense	Large_intestine
COSM5741009	c.2185C>T	p.R729W	Substitution - Missense	Small_intestine
COSM436682	c.1700G>A	p.G567E	Substitution - Missense	Breast
COSM1383595	c.2763C>T	p.N921N	Substitution - coding silent	Large_intestine
COSM979879	c.420G>A	p.E140E	Substitution - coding silent	Endometrium
COSM979881	c.178C>T	p.R60W	Substitution - Missense	Endometrium
COSM3742264	c.1873G>T	p.G625*	Substitution - Nonsense	Liver
COSM288216	c.1140C>A	p.V380V	Substitution - coding silent	Large_intestine
COSM4506263	c.711C>T	p.S237S	Substitution - coding silent	Skin
COSM3686130	c.1165-3delC	p.?	Unknown	Large_intestine
COSM5762115	c.3208C>T	p.R1070W	Substitution - Missense	Pancreas
COSM979849	c.3028G>A	p.A1010T	Substitution - Missense	Endometrium
COSM979877	c.588G>T	p.K196N	Substitution - Missense	Endometrium
COSM5442112	c.2268C>T	p.P756P	Substitution - coding silent	Oesophagus
COSM3190638	c.688G>C	p.G230R	Substitution - Missense	Large_intestine
COSM1383594	c.2793delC	p.I932fs*14	Deletion - Frameshift	Large_intestine
COSM3795662	c.263A>T	p.Q88L	Substitution - Missense	Urinary_tract
COSM1383604	c.923C>T	p.S308L	Substitution - Missense	Oesophagus
COSM1180418	c.2306-1G>A	p.?	Unknown	Prostate
COSM3370749	c.964C>G	p.P322A	Substitution - Missense	Thyroid
COSM4780422	c.1297G>T	p.E433*	Substitution - Nonsense	Liver
COSM1209386	c.3330-2A>G	p.?	Unknown	Large_intestine
COSM3787346	c.738C>T	p.Y246Y	Substitution - coding silent	Pancreas
COSM979847	c.3154G>A	p.E1052K	Substitution - Missense	Endometrium
COSM3717402	c.1317C>T	p.H439H	Substitution - coding silent	Liver
COSM1383604	c.923C>T	p.S308L	Substitution - Missense	Large_intestine
COSM3387927	c.1702G>A	p.A568T	Substitution - Missense	Pancreas
COSM1383594	c.2793delC	p.I932fs*14	Deletion - Frameshift	Large_intestine
COSM979859	c.2330C>T	p.A777V	Substitution - Missense	Endometrium
COSM3712507	c.2327A>G	p.Y776C	Substitution - Missense	Upper_aerodigestive_tract
COSM1679859	c.3263C>T	p.A1088V	Substitution - Missense	Large_intestine
COSM1209388	c.2947T>G	p.F983V	Substitution - Missense	Large_intestine
COSM3517981	c.3359C>T	p.P1120L	Substitution - Missense	Skin
COSM4876871	c.910G>T	p.G304W	Substitution - Missense	Prostate
COSM4066857	c.2094C>T	p.C698C	Substitution - coding silent	Stomach
COSM3730023	c.2793_2794insC	p.I932fs*24	Insertion - Frameshift	Large_intestine
COSM1383594	c.2793delC	p.I932fs*14	Deletion - Frameshift	Large_intestine
COSM5571773	c.2029G>A	p.V677I	Substitution - Missense	Prostate
COSM979871	c.1181C>T	p.S394L	Substitution - Missense	Endometrium
COSM706189	c.2161A>G	p.T721A	Substitution - Missense	Lung
COSM979849	c.3028G>A	p.A1010T	Substitution - Missense	Large_intestine
COSM3736164	c.1779C>G	p.D593E	Substitution - Missense	Skin
COSM3517983	c.3192C>T	p.F1064F	Substitution - coding silent	Skin
COSM5620937	c.1819G>A	p.E607K	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4790486	c.1638C>A	p.T546T	Substitution - coding silent	Liver
COSM3517988	c.571C>T	p.L191F	Substitution - Missense	Skin
COSM4151630	c.2527T>C	p.C843R	Substitution - Missense	Kidney
COSM5833307	c.1114delA	p.I372fs*3	Deletion - Frameshift	Breast

> Text Mining based Variations [ TOP ]
There is no record for HDAC5.

Summary
Symbol	HDAC5
Name	histone deacetylase 5
Aliases	KIAA0600; NY-CO-9; FLJ90614; HD5; antigen NY-CO-9
Location	17q21.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

[ TOP ]

Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
Q9UQL6	292	T	Phosphothreonine	PKC	No	None detected
Q9UQL6	498	S	Phosphoserine	AMPK, CaMK1, SIK1 and PKD/PRKD1	No	None detected
Q9UQL6	533	K	N6-acetyllysine	-	No	None detected
Q9UQL6	611	S	Phosphoserine	-	No	None detected
Q9UQL6	661	S	Phosphoserine	-	No	None detected
Q9UQL6	1108	S	Phosphoserine	-	No	None detected

Summary
Symbol	HDAC5
Name	histone deacetylase 5
Aliases	KIAA0600; NY-CO-9; FLJ90614; HD5; antigen NY-CO-9
Location	17q21.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	6.56	5.726	-0.932	5.05e-09	Under
BRCA	Breast invasive carcinoma	112	1100	6.501	6.033	-0.434	1.21e-11	NS
CESC	Cervical and endocervical cancers	3	306	7.368	5.985	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	5.935	5.564	-0.382	0.00159	NS
ESCA	Esophageal carcinoma	11	185	5.959	5.668	-0.623	0.00271	Under
GBM	Glioblastoma multiforme	5	166	7.43	6.012	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	6.401	5.732	-0.673	3.49e-13	Under
KIRC	Kidney renal clear cell carcinoma	72	534	6.198	6.106	-0.087	0.194	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	6.474	5.931	-0.5	2.68e-07	NS
LAML	Acute Myeloid Leukemia	0	173	NA	6.615	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	6.994	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	5.054	5.648	0.578	1.02e-08	NS
LUAD	Lung adenocarcinoma	59	517	6.34	5.968	-0.399	2.41e-07	NS
LUSC	Lung squamous cell carcinoma	51	501	6.333	5.675	-0.632	5.22e-14	Under
OV	Ovarian serous cystadenocarcinoma	0	307	NA	5.922	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	6.173	6.082	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	6.439	7.376	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	6.476	6.276	-0.173	0.00515	NS
READ	Rectum adenocarcinoma	10	167	5.802	5.74	-0.067	0.82	NS
SARC	Sarcoma	2	263	6.575	6.633	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	5.822	6.321	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	6.438	5.55	-0.9	1e-10	Under
TGCT	Testicular Germ Cell Tumors	0	156	NA	6.752	NA	NA	NA
THCA	Thyroid carcinoma	59	509	6.5	6.675	0.152	0.00194	NS
THYM	Thymoma	2	120	6.276	6.077	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	7.206	5.849	-1.209	1.13e-22	Under

> Cancer Cell Line Encyclopedia (CCLE)

[ TOP ]

Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	7.1
Autonomic ganglia	CHP212	6
Autonomic ganglia	IMR32	7.1
Autonomic ganglia	KELLY	6.3
Autonomic ganglia	KPNRTBM1	6.4
Autonomic ganglia	KPNSI9S	5.6
Autonomic ganglia	KPNYN	6.1
Autonomic ganglia	MHHNB11	6.5
Autonomic ganglia	NB1	6.3
Autonomic ganglia	NH6	6
Autonomic ganglia	SHSY5Y	6.7
Autonomic ganglia	SIMA	6.7
Autonomic ganglia	SKNAS	5.9
Autonomic ganglia	SKNBE2	6
Autonomic ganglia	SKNDZ	6.3
Autonomic ganglia	SKNFI	6.2
Autonomic ganglia	SKNSH	5.5
Biliary tract	HUCCT1	5.7
Biliary tract	HUH28	6.2
Biliary tract	SNU1079	6
Biliary tract	SNU1196	5.6
Biliary tract	SNU245	5.6
Biliary tract	SNU308	5.7
Biliary tract	SNU478	5.4
Bone	143B	5.3
Bone	A673	5.6
Bone	CADOES1	6.2
Bone	CAL78	5.7
Bone	G292CLONEA141B1	5.8
Bone	HOS	5.9
Bone	HS706T	5.8
Bone	HS737T	5.9
Bone	HS819T	6.3
Bone	HS821T	6
Bone	HS822T	6.3
Bone	HS863T	6.3
Bone	HS870T	5.8
Bone	HS888T	5.8
Bone	MG63	6.1
Bone	MHHES1	6.3
Bone	OUMS27	5.3
Bone	RDES	6.2
Bone	SJSA1	7
Bone	SKES1	5.5
Bone	SKNMC	6
Bone	SW1353	5.7
Bone	T173	5.8
Bone	TC71	5.3
Bone	U2OS	5.5
Breast	AU565	5.8
Breast	BT20	5.1
Breast	BT474	4.7
Breast	BT483	6.2
Breast	BT549	5.3
Breast	CAL120	5.3
Breast	CAL148	6.2
Breast	CAL51	5.2
Breast	CAL851	5.6
Breast	CAMA1	5.5
Breast	DU4475	5.5
Breast	EFM192A	5.3
Breast	EFM19	5.6
Breast	EVSAT	5.5
Breast	HCC1143	5.6
Breast	HCC1187	5.7
Breast	HCC1395	5.4
Breast	HCC1419	5.6
Breast	HCC1428	5.8
Breast	HCC1500	5.5
Breast	HCC1569	6.1
Breast	HCC1599	6.4
Breast	HCC1806	5.8
Breast	HCC1937	5.2
Breast	HCC1954	5.5
Breast	HCC202	5.8
Breast	HCC2157	5.6
Breast	HCC2218	5.3
Breast	HCC38	5.3
Breast	HCC70	5.6
Breast	HDQP1	5.7
Breast	HMC18	6.1
Breast	HS274T	6.4
Breast	HS281T	5.9
Breast	HS343T	6
Breast	HS578T	5.7
Breast	HS606T	5.8
Breast	HS739T	5.9
Breast	HS742T	5.6
Breast	JIMT1	6.8
Breast	KPL1	5.3
Breast	MCF7	5.3
Breast	MDAMB134VI	5.9
Breast	MDAMB157	5.4
Breast	MDAMB175VII	5.4
Breast	MDAMB231	5.7
Breast	MDAMB361	5.1
Breast	MDAMB415	5.6
Breast	MDAMB436	4.8
Breast	MDAMB453	5
Breast	MDAMB468	6
Breast	SKBR3	6
Breast	T47D	6
Breast	UACC812	6.3
Breast	UACC893	5.8
Breast	YMB1	5.6
Breast	ZR751	5.4
Breast	ZR7530	5.6
Central nervous system	1321N1	5.7
Central nervous system	42MGBA	5.6
Central nervous system	8MGBA	5.8
Central nervous system	A172	6.2
Central nervous system	AM38	5.5
Central nervous system	BECKER	4.9
Central nervous system	CAS1	5.9
Central nervous system	CCFSTTG1	5.5
Central nervous system	D283MED	7.4
Central nervous system	D341MED	7.2
Central nervous system	DAOY	5.4
Central nervous system	DBTRG05MG	5.1
Central nervous system	DKMG	5.8
Central nervous system	GAMG	5.3
Central nervous system	GB1	6.1
Central nervous system	GI1	6.1
Central nervous system	GMS10	5.4
Central nervous system	GOS3	6
Central nervous system	H4	5.3
Central nervous system	HS683	5.2
Central nervous system	KALS1	5.7
Central nervous system	KG1C	5.2
Central nervous system	KNS42	5.5
Central nervous system	KNS60	5.7
Central nervous system	KNS81	5.6
Central nervous system	KS1	5.5
Central nervous system	LN18	5.5
Central nervous system	LN229	5.1
Central nervous system	M059K	5.7
Central nervous system	MOGGCCM	5.5
Central nervous system	MOGGUVW	5.5
Central nervous system	NMCG1	5.2
Central nervous system	ONS76	5.9
Central nervous system	SF126	5.6
Central nervous system	SF295	5.6
Central nervous system	SNB19	5.3
Central nervous system	SNU1105	6.2
Central nervous system	SNU201	6.2
Central nervous system	SNU466	5.7
Central nervous system	SNU489	6.4
Central nervous system	SNU626	5.8
Central nervous system	SNU738	5.1
Central nervous system	SW1088	5.6
Central nervous system	SW1783	5.1
Central nervous system	T98G	5.9
Central nervous system	TM31	6.1
Central nervous system	U118MG	5.6
Central nervous system	U138MG	5.7
Central nervous system	U251MG	6.2
Central nervous system	U87MG	5.6
Central nervous system	YH13	5.8
Central nervous system	YKG1	6
Endometrium	AN3CA	5
Endometrium	COLO684	6.4
Endometrium	EFE184	5.4
Endometrium	EN	5.4
Endometrium	ESS1	5.3
Endometrium	HEC108	6
Endometrium	HEC151	5.3
Endometrium	HEC1A	4.8
Endometrium	HEC1B	5.7
Endometrium	HEC251	5
Endometrium	HEC265	5.6
Endometrium	HEC50B	5.4
Endometrium	HEC59	5.7
Endometrium	HEC6	5.1
Endometrium	ISHIKAWAHERAKLIO02ER	5.1
Endometrium	JHUEM1	5
Endometrium	JHUEM2	5.1
Endometrium	JHUEM3	5.7
Endometrium	KLE	5.6
Endometrium	MFE280	5.8
Endometrium	MFE296	5.3
Endometrium	MFE319	5.6
Endometrium	RL952	5.2
Endometrium	SNGM	5.7
Endometrium	SNU1077	6.5
Endometrium	SNU685	6.4
Endometrium	TEN	5.5
Haematopoietic and lymphoid	697	6.6
Haematopoietic and lymphoid	A3KAW	5.7
Haematopoietic and lymphoid	A4FUK	6.1
Haematopoietic and lymphoid	ALLSIL	6.3
Haematopoietic and lymphoid	AML193	6
Haematopoietic and lymphoid	AMO1	6
Haematopoietic and lymphoid	BCP1	5.6
Haematopoietic and lymphoid	BDCM	6.1
Haematopoietic and lymphoid	BL41	5.6
Haematopoietic and lymphoid	BL70	5.8
Haematopoietic and lymphoid	BV173	7.1
Haematopoietic and lymphoid	CA46	6
Haematopoietic and lymphoid	CI1	5.6
Haematopoietic and lymphoid	CMK115	5.2
Haematopoietic and lymphoid	CMK86	5.8
Haematopoietic and lymphoid	CMK	5.8
Haematopoietic and lymphoid	CMLT1	5.4
Haematopoietic and lymphoid	COLO775	6.9
Haematopoietic and lymphoid	DAUDI	5.7
Haematopoietic and lymphoid	DB	5.7
Haematopoietic and lymphoid	DEL	5.4
Haematopoietic and lymphoid	DND41	5.4
Haematopoietic and lymphoid	DOHH2	6.1
Haematopoietic and lymphoid	EB1	5.8
Haematopoietic and lymphoid	EB2	5.6
Haematopoietic and lymphoid	EHEB	6.1
Haematopoietic and lymphoid	EJM	6.6
Haematopoietic and lymphoid	EM2	6.5
Haematopoietic and lymphoid	EOL1	6
Haematopoietic and lymphoid	F36P	5.4
Haematopoietic and lymphoid	GA10	5.7
Haematopoietic and lymphoid	GDM1	6.4
Haematopoietic and lymphoid	GRANTA519	6.2
Haematopoietic and lymphoid	HDLM2	6.2
Haematopoietic and lymphoid	HDMYZ	5.4
Haematopoietic and lymphoid	HEL9217	5.9
Haematopoietic and lymphoid	HEL	6.1
Haematopoietic and lymphoid	HH	5.6
Haematopoietic and lymphoid	HL60	6.2
Haematopoietic and lymphoid	HPBALL	6.3
Haematopoietic and lymphoid	HS604T	6.9
Haematopoietic and lymphoid	HS611T	5.4
Haematopoietic and lymphoid	HS616T	6.3
Haematopoietic and lymphoid	HS751T	5.4
Haematopoietic and lymphoid	HT	5.6
Haematopoietic and lymphoid	HTK	5.9
Haematopoietic and lymphoid	HUNS1	6.2
Haematopoietic and lymphoid	HUT102	6
Haematopoietic and lymphoid	HUT78	5.3
Haematopoietic and lymphoid	JEKO1	6.2
Haematopoietic and lymphoid	JK1	5.9
Haematopoietic and lymphoid	JM1	6
Haematopoietic and lymphoid	JURKAT	5.6
Haematopoietic and lymphoid	JURLMK1	6.1
Haematopoietic and lymphoid	JVM2	6
Haematopoietic and lymphoid	JVM3	5.9
Haematopoietic and lymphoid	K562	6.2
Haematopoietic and lymphoid	KARPAS299	5.9
Haematopoietic and lymphoid	KARPAS422	5.5
Haematopoietic and lymphoid	KARPAS620	6.7
Haematopoietic and lymphoid	KASUMI1	5.4
Haematopoietic and lymphoid	KASUMI2	6.5
Haematopoietic and lymphoid	KASUMI6	6
Haematopoietic and lymphoid	KCL22	6.1
Haematopoietic and lymphoid	KE37	5.7
Haematopoietic and lymphoid	KE97	6.2
Haematopoietic and lymphoid	KG1	5.6
Haematopoietic and lymphoid	KHM1B	6.4
Haematopoietic and lymphoid	KIJK	5.2
Haematopoietic and lymphoid	KMH2	6
Haematopoietic and lymphoid	KMM1	6.2
Haematopoietic and lymphoid	KMS11	6.8
Haematopoietic and lymphoid	KMS12BM	6.2
Haematopoietic and lymphoid	KMS18	6.1
Haematopoietic and lymphoid	KMS20	6.2
Haematopoietic and lymphoid	KMS21BM	6.5
Haematopoietic and lymphoid	KMS26	6.5
Haematopoietic and lymphoid	KMS27	5.7
Haematopoietic and lymphoid	KMS28BM	6.4
Haematopoietic and lymphoid	KMS34	6.7
Haematopoietic and lymphoid	KO52	5.8
Haematopoietic and lymphoid	KOPN8	6.1
Haematopoietic and lymphoid	KU812	5.4
Haematopoietic and lymphoid	KYO1	5.9
Haematopoietic and lymphoid	L1236	5.5
Haematopoietic and lymphoid	L363	6.5
Haematopoietic and lymphoid	L428	5.4
Haematopoietic and lymphoid	L540	6.3
Haematopoietic and lymphoid	LAMA84	5.9
Haematopoietic and lymphoid	LOUCY	6.4
Haematopoietic and lymphoid	LP1	6.5
Haematopoietic and lymphoid	M07E	5.6
Haematopoietic and lymphoid	MC116	5.6
Haematopoietic and lymphoid	ME1	6.5
Haematopoietic and lymphoid	MEC1	5.7
Haematopoietic and lymphoid	MEC2	6
Haematopoietic and lymphoid	MEG01	5.4
Haematopoietic and lymphoid	MHHCALL2	6.3
Haematopoietic and lymphoid	MHHCALL3	6.8
Haematopoietic and lymphoid	MHHCALL4	6.6
Haematopoietic and lymphoid	MINO	5.8
Haematopoietic and lymphoid	MJ	5.3
Haematopoietic and lymphoid	MM1S	6.3
Haematopoietic and lymphoid	MOLM13	6.2
Haematopoietic and lymphoid	MOLM16	4.6
Haematopoietic and lymphoid	MOLM6	6.2
Haematopoietic and lymphoid	MOLP2	6.5
Haematopoietic and lymphoid	MOLP8	6.2
Haematopoietic and lymphoid	MOLT13	5.5
Haematopoietic and lymphoid	MOLT16	5.4
Haematopoietic and lymphoid	MOLT4	5.3
Haematopoietic and lymphoid	MONOMAC1	6.2
Haematopoietic and lymphoid	MONOMAC6	5.9
Haematopoietic and lymphoid	MOTN1	6.7
Haematopoietic and lymphoid	MUTZ5	6.8
Haematopoietic and lymphoid	MV411	6.3
Haematopoietic and lymphoid	NALM19	6.8
Haematopoietic and lymphoid	NALM1	6.5
Haematopoietic and lymphoid	NALM6	6.9
Haematopoietic and lymphoid	NAMALWA	6.4
Haematopoietic and lymphoid	NB4	5.8
Haematopoietic and lymphoid	NCIH929	6.2
Haematopoietic and lymphoid	NCO2	5.1
Haematopoietic and lymphoid	NOMO1	6
Haematopoietic and lymphoid	NUDHL1	6.1
Haematopoietic and lymphoid	NUDUL1	6
Haematopoietic and lymphoid	OCIAML2	6.2
Haematopoietic and lymphoid	OCIAML3	6.1
Haematopoietic and lymphoid	OCIAML5	6
Haematopoietic and lymphoid	OCILY10	5.8
Haematopoietic and lymphoid	OCILY19	6.2
Haematopoietic and lymphoid	OCILY3	5.6
Haematopoietic and lymphoid	OCIM1	6.2
Haematopoietic and lymphoid	OPM2	6.3
Haematopoietic and lymphoid	P12ICHIKAWA	5.7
Haematopoietic and lymphoid	P31FUJ	6
Haematopoietic and lymphoid	P3HR1	5.8
Haematopoietic and lymphoid	PCM6	6.2
Haematopoietic and lymphoid	PEER	5.7
Haematopoietic and lymphoid	PF382	6.3
Haematopoietic and lymphoid	PFEIFFER	5.6
Haematopoietic and lymphoid	PL21	6.6
Haematopoietic and lymphoid	RAJI	5.3
Haematopoietic and lymphoid	RCHACV	6.3
Haematopoietic and lymphoid	REC1	5.7
Haematopoietic and lymphoid	REH	6.2
Haematopoietic and lymphoid	RI1	6.1
Haematopoietic and lymphoid	RL	5.8
Haematopoietic and lymphoid	RPMI8226	6
Haematopoietic and lymphoid	RPMI8402	6.1
Haematopoietic and lymphoid	RS411	6.4
Haematopoietic and lymphoid	SEM	6.6
Haematopoietic and lymphoid	SET2	5.2
Haematopoietic and lymphoid	SIGM5	5.9
Haematopoietic and lymphoid	SKM1	6.3
Haematopoietic and lymphoid	SKMM2	6.3
Haematopoietic and lymphoid	SR786	5.8
Haematopoietic and lymphoid	ST486	6.3
Haematopoietic and lymphoid	SUDHL10	6.2
Haematopoietic and lymphoid	SUDHL1	5.7
Haematopoietic and lymphoid	SUDHL4	6.1
Haematopoietic and lymphoid	SUDHL5	5.6
Haematopoietic and lymphoid	SUDHL6	5.4
Haematopoietic and lymphoid	SUDHL8	6.3
Haematopoietic and lymphoid	SUPB15	6.2
Haematopoietic and lymphoid	SUPHD1	6.1
Haematopoietic and lymphoid	SUPM2	5.1
Haematopoietic and lymphoid	SUPT11	5.7
Haematopoietic and lymphoid	SUPT1	5.7
Haematopoietic and lymphoid	TALL1	5.1
Haematopoietic and lymphoid	TF1	5.3
Haematopoietic and lymphoid	THP1	6.3
Haematopoietic and lymphoid	TO175T	6.1
Haematopoietic and lymphoid	TOLEDO	6.3
Haematopoietic and lymphoid	U266B1	6.2
Haematopoietic and lymphoid	U937	5.9
Haematopoietic and lymphoid	UT7	6.2
Haematopoietic and lymphoid	WSUDLCL2	5.9
Kidney	769P	4.8
Kidney	786O	5.2
Kidney	A498	5.9
Kidney	A704	5.4
Kidney	ACHN	4.8
Kidney	BFTC909	6.4
Kidney	CAKI1	5.6
Kidney	CAKI2	5.3
Kidney	CAL54	5.8
Kidney	KMRC1	5.3
Kidney	KMRC20	4.9
Kidney	KMRC2	5.5
Kidney	KMRC3	5.8
Kidney	OSRC2	5.4
Kidney	RCC10RGB	5
Kidney	SNU1272	5
Kidney	SNU349	5.7
Kidney	TUHR10TKB	4.4
Kidney	TUHR14TKB	5.2
Kidney	TUHR4TKB	5.4
Kidney	VMRCRCW	5.7
Kidney	VMRCRCZ	4.8
Large intestine	C2BBE1	5.5
Large intestine	CCK81	5.4
Large intestine	CL11	5.7
Large intestine	CL14	5.7
Large intestine	CL34	5.3
Large intestine	CL40	5.7
Large intestine	COLO205	5
Large intestine	COLO320	6.1
Large intestine	COLO678	5.7
Large intestine	CW2	5.3
Large intestine	DLD1	5.3
Large intestine	GP2D	5.3
Large intestine	HCC56	4.9
Large intestine	HCT116	5.3
Large intestine	HCT15	5.7
Large intestine	HS675T	6.3
Large intestine	HS698T	6
Large intestine	HT115	5.7
Large intestine	HT29	5.4
Large intestine	HT55	5.2
Large intestine	KM12	5.7
Large intestine	LOVO	5.2
Large intestine	LS1034	5.4
Large intestine	LS123	5.3
Large intestine	LS180	5
Large intestine	LS411N	5.3
Large intestine	LS513	5
Large intestine	MDST8	5.2
Large intestine	NCIH508	6.4
Large intestine	NCIH716	5.4
Large intestine	NCIH747	5.4
Large intestine	OUMS23	5.9
Large intestine	RCM1	5.9
Large intestine	RKO	5.4
Large intestine	SKCO1	5.1
Large intestine	SNU1040	5.9
Large intestine	SNU1197	6
Large intestine	SNU175	5.3
Large intestine	SNU283	5.6
Large intestine	SNU407	5.3
Large intestine	SNU503	5.7
Large intestine	SNU61	5.3
Large intestine	SNU81	5.9
Large intestine	SNUC1	5.6
Large intestine	SNUC2A	5.3
Large intestine	SNUC4	5.1
Large intestine	SNUC5	5
Large intestine	SW1116	5.7
Large intestine	SW1417	5.4
Large intestine	SW1463	5.2
Large intestine	SW403	5.7
Large intestine	SW480	5.4
Large intestine	SW48	5
Large intestine	SW620	5
Large intestine	SW837	5.4
Large intestine	SW948	5.8
Large intestine	T84	5.3
Liver	ALEXANDERCELLS	5.3
Liver	C3A	6.2
Liver	HEP3B217	5.2
Liver	HEPG2	5.7
Liver	HLE	5.6
Liver	HLF	5.2
Liver	HUH1	5.4
Liver	HUH6	4.8
Liver	HUH7	5.6
Liver	JHH1	5.9
Liver	JHH2	5.7
Liver	JHH4	6.5
Liver	JHH5	5.3
Liver	JHH6	5.5
Liver	JHH7	6.2
Liver	LI7	6.2
Liver	PLCPRF5	5.7
Liver	SKHEP1	5.3
Liver	SNU182	5.8
Liver	SNU387	5.4
Liver	SNU398	5.3
Liver	SNU423	5.5
Liver	SNU449	5.7
Liver	SNU475	5.7
Liver	SNU761	6.2
Liver	SNU878	5.8
Liver	SNU886	6
Lung	A549	5.3
Lung	ABC1	5.7
Lung	BEN	5.5
Lung	CAL12T	5.6
Lung	CALU1	5.3
Lung	CALU3	5.7
Lung	CALU6	5.3
Lung	CHAGOK1	5.3
Lung	COLO668	5.5
Lung	COLO699	5.4
Lung	CORL105	4.8
Lung	CORL23	5.8
Lung	CORL24	6
Lung	CORL279	6.7
Lung	CORL311	6.3
Lung	CORL47	6.4
Lung	CORL51	6.4
Lung	CORL88	5.9
Lung	CORL95	6.4
Lung	CPCN	6.3
Lung	DMS114	6
Lung	DMS153	5.5
Lung	DMS273	5.8
Lung	DMS454	5.5
Lung	DMS53	5
Lung	DMS79	6.2
Lung	DV90	5.1
Lung	EBC1	5
Lung	EPLC272H	5.3
Lung	HARA	5.5
Lung	HCC1171	6
Lung	HCC1195	6.3
Lung	HCC15	5.1
Lung	HCC2279	5.6
Lung	HCC2935	5.3
Lung	HCC33	6.7
Lung	HCC366	4.8
Lung	HCC4006	4.8
Lung	HCC44	6
Lung	HCC78	5.6
Lung	HCC827	5.1
Lung	HCC95	5.6
Lung	HLC1	6.9
Lung	HLFA	5.6
Lung	HS229T	5.7
Lung	HS618T	5.9
Lung	IALM	6.1
Lung	KNS62	5.8
Lung	LC1F	5.8
Lung	LC1SQSF	5.6
Lung	LCLC103H	5.5
Lung	LCLC97TM1	5.6
Lung	LK2	5.7
Lung	LOUNH91	5
Lung	LU65	4.5
Lung	LU99	5.4
Lung	LUDLU1	5.3
Lung	LXF289	5.5
Lung	MORCPR	5.6
Lung	NCIH1048	5.6
Lung	NCIH1092	5.4
Lung	NCIH1105	5.8
Lung	NCIH1155	5.1
Lung	NCIH1184	6.2
Lung	NCIH1299	5.4
Lung	NCIH1339	5.1
Lung	NCIH1341	5.5
Lung	NCIH1355	4.8
Lung	NCIH1373	5.7
Lung	NCIH1385	7.4
Lung	NCIH1395	5.3
Lung	NCIH1435	5.2
Lung	NCIH1436	5.3
Lung	NCIH1437	5.6
Lung	NCIH146	6
Lung	NCIH1563	5.2
Lung	NCIH1568	5.4
Lung	NCIH1573	5.3
Lung	NCIH1581	5.6
Lung	NCIH1618	6.5
Lung	NCIH1623	5.9
Lung	NCIH1648	5.6
Lung	NCIH1650	5.4
Lung	NCIH1651	4.7
Lung	NCIH1666	5.2
Lung	NCIH1693	4.9
Lung	NCIH1694	5.5
Lung	NCIH1703	5.6
Lung	NCIH1734	5.5
Lung	NCIH1755	5.2
Lung	NCIH1781	5.7
Lung	NCIH1792	5.2
Lung	NCIH1793	5.2
Lung	NCIH1836	5.9
Lung	NCIH1838	5
Lung	NCIH1869	5.3
Lung	NCIH1876	5.8
Lung	NCIH1915	5.2
Lung	NCIH1930	5.4
Lung	NCIH1944	4.8
Lung	NCIH1963	5.9
Lung	NCIH196	5.9
Lung	NCIH1975	5.1
Lung	NCIH2009	5.1
Lung	NCIH2023	5.4
Lung	NCIH2029	5.6
Lung	NCIH2030	5.4
Lung	NCIH2066	5.7
Lung	NCIH2081	6
Lung	NCIH2085	5.3
Lung	NCIH2087	5.5
Lung	NCIH209	5.4
Lung	NCIH2106	6.8
Lung	NCIH2110	5.2
Lung	NCIH211	5.4
Lung	NCIH2122	5.4
Lung	NCIH2126	4.9
Lung	NCIH2141	7.2
Lung	NCIH2170	5.2
Lung	NCIH2171	6.2
Lung	NCIH2172	5.1
Lung	NCIH2196	5.3
Lung	NCIH2227	6.5
Lung	NCIH2228	5.2
Lung	NCIH226	4.8
Lung	NCIH2286	5.2
Lung	NCIH2291	5.3
Lung	NCIH2342	5.8
Lung	NCIH2347	5.5
Lung	NCIH23	5.5
Lung	NCIH2405	5.3
Lung	NCIH2444	5.8
Lung	NCIH292	5.4
Lung	NCIH322	5.6
Lung	NCIH3255	5.5
Lung	NCIH358	5.2
Lung	NCIH441	5.7
Lung	NCIH446	6
Lung	NCIH460	4.9
Lung	NCIH510	5.3
Lung	NCIH520	4.9
Lung	NCIH522	5.8
Lung	NCIH524	6
Lung	NCIH526	6.2
Lung	NCIH596	5
Lung	NCIH647	5
Lung	NCIH650	5.6
Lung	NCIH661	5.9
Lung	NCIH69	6
Lung	NCIH727	5.1
Lung	NCIH810	5.5
Lung	NCIH82	6.1
Lung	NCIH838	5.7
Lung	NCIH841	6
Lung	NCIH854	6.3
Lung	NCIH889	6.1
Lung	PC14	5.3
Lung	RERFLCAD1	5.4
Lung	RERFLCAD2	5.3
Lung	RERFLCAI	5
Lung	RERFLCKJ	5.6
Lung	RERFLCMS	5.7
Lung	RERFLCSQ1	5.2
Lung	SBC5	5.9
Lung	SCLC21H	6.3
Lung	SHP77	5.6
Lung	SKLU1	5.3
Lung	SKMES1	5.3
Lung	SQ1	5.7
Lung	SW1271	5.3
Lung	SW1573	5
Lung	SW900	5.5
Lung	VMRCLCD	5.5
Lung	VMRCLCP	5.4
Oesophagus	COLO680N	6
Oesophagus	ECGI10	5.7
Oesophagus	KYSE140	5.8
Oesophagus	KYSE150	5.8
Oesophagus	KYSE180	5.3
Oesophagus	KYSE270	5.6
Oesophagus	KYSE30	6.1
Oesophagus	KYSE410	5.2
Oesophagus	KYSE450	5.2
Oesophagus	KYSE510	5.2
Oesophagus	KYSE520	5.3
Oesophagus	KYSE70	5.9
Oesophagus	OE19	5.2
Oesophagus	OE33	5.6
Oesophagus	TE10	5.4
Oesophagus	TE11	5.4
Oesophagus	TE14	5.8
Oesophagus	TE15	5.1
Oesophagus	TE1	5.3
Oesophagus	TE4	5.3
Oesophagus	TE5	5.6
Oesophagus	TE6	5.8
Oesophagus	TE8	5.6
Oesophagus	TE9	5.7
Oesophagus	TT	5.8
Ovary	59M	6.3
Ovary	A2780	5.9
Ovary	CAOV3	5.1
Ovary	CAOV4	5.8
Ovary	COLO704	5.7
Ovary	COV318	5.4
Ovary	COV362	4.9
Ovary	COV434	5.2
Ovary	COV504	4.9
Ovary	COV644	4.8
Ovary	EFO21	5.3
Ovary	EFO27	5.3
Ovary	ES2	5.1
Ovary	FUOV1	6.3
Ovary	HEYA8	5.2
Ovary	HS571T	6
Ovary	IGROV1	5.8
Ovary	JHOC5	5.6
Ovary	JHOM1	5.3
Ovary	JHOM2B	5.2
Ovary	JHOS2	4.7
Ovary	JHOS4	5.4
Ovary	KURAMOCHI	6.1
Ovary	MCAS	5.7
Ovary	NIHOVCAR3	5.4
Ovary	OAW28	5.7
Ovary	OAW42	4.9
Ovary	OC314	5.4
Ovary	OC316	4.9
Ovary	ONCODG1	5.3
Ovary	OV56	6.1
Ovary	OV7	5.3
Ovary	OV90	5.7
Ovary	OVCAR4	5
Ovary	OVCAR8	5.6
Ovary	OVISE	5.5
Ovary	OVK18	5.7
Ovary	OVKATE	5.7
Ovary	OVMANA	5.7
Ovary	OVSAHO	5.1
Ovary	OVTOKO	5.3
Ovary	RMGI	6.3
Ovary	RMUGS	5.4
Ovary	SKOV3	5.3
Ovary	SNU119	5.5
Ovary	SNU840	4.9
Ovary	SNU8	5.6
Ovary	TOV112D	6.2
Ovary	TOV21G	5.3
Ovary	TYKNU	5.1
Pancreas	ASPC1	5.7
Pancreas	BXPC3	5.4
Pancreas	CAPAN1	6.2
Pancreas	CAPAN2	5.1
Pancreas	CFPAC1	5.6
Pancreas	DANG	5.3
Pancreas	HPAC	5.9
Pancreas	HPAFII	5.8
Pancreas	HS766T	5.5
Pancreas	HUPT3	5.7
Pancreas	HUPT4	5.8
Pancreas	KCIMOH1	5.9
Pancreas	KLM1	5.9
Pancreas	KP2	5.7
Pancreas	KP3	5.4
Pancreas	KP4	6
Pancreas	L33	5.3
Pancreas	MIAPACA2	5
Pancreas	PANC0203	5.7
Pancreas	PANC0213	5.2
Pancreas	PANC0327	5.3
Pancreas	PANC0403	4.9
Pancreas	PANC0504	5.1
Pancreas	PANC0813	5.7
Pancreas	PANC1005	5.6
Pancreas	PANC1	5.5
Pancreas	PATU8902	5.1
Pancreas	PATU8988S	5.6
Pancreas	PATU8988T	5.1
Pancreas	PK1	5.1
Pancreas	PK45H	5.5
Pancreas	PK59	5.8
Pancreas	PL45	5.6
Pancreas	PSN1	5.3
Pancreas	QGP1	5.5
Pancreas	SNU213	5.7
Pancreas	SNU324	5.7
Pancreas	SNU410	5.7
Pancreas	SU8686	5.5
Pancreas	SUIT2	4.9
Pancreas	SW1990	5.2
Pancreas	T3M4	5.6
Pancreas	TCCPAN2	5.4
Pancreas	YAPC	5.6
Pleura	ACCMESO1	5
Pleura	DM3	6.8
Pleura	ISTMES1	5
Pleura	ISTMES2	5.3
Pleura	JL1	5.8
Pleura	MPP89	5.3
Pleura	MSTO211H	5
Pleura	NCIH2052	5.2
Pleura	NCIH2452	5
Pleura	NCIH28	5.3
Prostate	22RV1	5.9
Prostate	DU145	4.9
Prostate	LNCAPCLONEFGC	5.5
Prostate	MDAPCA2B	5.9
Prostate	NCIH660	5.9
Prostate	PC3	5.7
Prostate	VCAP	5.8
Salivary gland	A253	4.7
Salivary gland	YD15	5.2
Skin	A101D	5.3
Skin	A2058	5.7
Skin	A375	5.8
Skin	C32	5.4
Skin	CHL1	5.6
Skin	CJM	6
Skin	COLO679	5.1
Skin	COLO741	5.6
Skin	COLO783	5.3
Skin	COLO792	5.8
Skin	COLO800	6.1
Skin	COLO818	5.6
Skin	COLO829	5.8
Skin	COLO849	6.1
Skin	G361	5.4
Skin	GRM	5.7
Skin	HMCB	5.4
Skin	HS294T	5.7
Skin	HS600T	5.7
Skin	HS688AT	6.9
Skin	HS695T	5.7
Skin	HS839T	6.1
Skin	HS852T	5.7
Skin	HS895T	5.8
Skin	HS934T	6
Skin	HS936T	6
Skin	HS939T	5.7
Skin	HS940T	6.5
Skin	HS944T	5.7
Skin	HT144	5.5
Skin	IGR1	5.1
Skin	IGR37	5.3
Skin	IGR39	5.4
Skin	IPC298	5.5
Skin	K029AX	5.1
Skin	LOXIMVI	5.8
Skin	MALME3M	5.6
Skin	MDAMB435S	5.6
Skin	MELHO	5.3
Skin	MELJUSO	5.5
Skin	MEWO	5.3
Skin	RPMI7951	5
Skin	RVH421	5.3
Skin	SH4	6
Skin	SKMEL1	5.6
Skin	SKMEL24	5.6
Skin	SKMEL28	5.6
Skin	SKMEL2	5.8
Skin	SKMEL30	5.4
Skin	SKMEL31	6.1
Skin	SKMEL3	5.7
Skin	SKMEL5	5.6
Skin	UACC257	5.3
Skin	UACC62	5.9
Skin	WM115	5.9
Skin	WM1799	5.6
Skin	WM2664	5.7
Skin	WM793	5.4
Skin	WM88	5.3
Skin	WM983B	5.3
Small intestine	HUTU80	5.7
Soft tissue	A204	5.8
Soft tissue	G401	5.7
Soft tissue	G402	5.4
Soft tissue	GCT	5.7
Soft tissue	HS729	6.1
Soft tissue	HT1080	5.1
Soft tissue	KYM1	6.2
Soft tissue	MESSA	5.8
Soft tissue	RD	5.3
Soft tissue	RH30	6.7
Soft tissue	RH41	7.8
Soft tissue	RKN	5.1
Soft tissue	S117	5.6
Soft tissue	SJRH30	6.3
Soft tissue	SKLMS1	5.4
Soft tissue	SKUT1	5.1
Soft tissue	TE125T	6.3
Soft tissue	TE159T	6.1
Soft tissue	TE441T	7.9
Soft tissue	TE617T	5.4
Stomach	2313287	5.1
Stomach	AGS	5.5
Stomach	AZ521	5.4
Stomach	ECC10	6.1
Stomach	ECC12	5.7
Stomach	FU97	5.4
Stomach	GCIY	5.3
Stomach	GSS	5.5
Stomach	GSU	5.7
Stomach	HGC27	5.8
Stomach	HS746T	5.2
Stomach	HUG1N	4.9
Stomach	IM95	5
Stomach	KATOIII	5.2
Stomach	KE39	5.6
Stomach	LMSU	5.2
Stomach	MKN1	5.5
Stomach	MKN45	5.3
Stomach	MKN74	5.4
Stomach	MKN7	5.6
Stomach	NCCSTCK140	6.3
Stomach	NCIN87	5.2
Stomach	NUGC2	6.3
Stomach	NUGC3	5.3
Stomach	NUGC4	6.2
Stomach	OCUM1	4.8
Stomach	RERFGC1B	5.6
Stomach	SH10TC	5.4
Stomach	SNU16	5.4
Stomach	SNU1	5.7
Stomach	SNU216	6
Stomach	SNU520	5.2
Stomach	SNU5	5.2
Stomach	SNU601	5.8
Stomach	SNU620	5.5
Stomach	SNU668	5.1
Stomach	SNU719	5.4
Stomach	TGBC11TKB	5.6
Thyroid	8305C	5.8
Thyroid	8505C	5.4
Thyroid	BCPAP	6.5
Thyroid	BHT101	5.5
Thyroid	CAL62	5.2
Thyroid	CGTHW1	5.6
Thyroid	FTC133	5.2
Thyroid	FTC238	5.1
Thyroid	ML1	5.4
Thyroid	SW579	5.5
Thyroid	TT2609C02	6.1
Thyroid	TT	6.1
Upper aerodigestive tract	BHY	5.5
Upper aerodigestive tract	BICR16	5.7
Upper aerodigestive tract	BICR18	5.7
Upper aerodigestive tract	BICR22	6.5
Upper aerodigestive tract	BICR31	5.4
Upper aerodigestive tract	BICR56	6.1
Upper aerodigestive tract	BICR6	6.2
Upper aerodigestive tract	CAL27	5.1
Upper aerodigestive tract	CAL33	6.3
Upper aerodigestive tract	DETROIT562	5
Upper aerodigestive tract	FADU	5.4
Upper aerodigestive tract	HS840T	5.8
Upper aerodigestive tract	HSC2	5.4
Upper aerodigestive tract	HSC3	5.7
Upper aerodigestive tract	HSC4	6.3
Upper aerodigestive tract	PECAPJ15	5.5
Upper aerodigestive tract	PECAPJ34CLONEC12	5.3
Upper aerodigestive tract	PECAPJ41CLONED2	5.5
Upper aerodigestive tract	PECAPJ49	5.4
Upper aerodigestive tract	SCC15	5.7
Upper aerodigestive tract	SCC25	5.6
Upper aerodigestive tract	SCC4	5.2
Upper aerodigestive tract	SCC9	5.4
Upper aerodigestive tract	SNU1076	6
Upper aerodigestive tract	SNU1214	5.7
Upper aerodigestive tract	SNU46	5.2
Upper aerodigestive tract	SNU899	5.7
Upper aerodigestive tract	YD10B	6.1
Upper aerodigestive tract	YD38	5.7
Upper aerodigestive tract	YD8	5.4
Urinary tract	5637	5.1
Urinary tract	639V	5.6
Urinary tract	647V	5.5
Urinary tract	BC3C	5.2
Urinary tract	BFTC905	5.4
Urinary tract	CAL29	5
Urinary tract	HS172T	6.1
Urinary tract	HT1197	4.7
Urinary tract	HT1376	5.7
Urinary tract	J82	5.3
Urinary tract	JMSU1	5.6
Urinary tract	KMBC2	5.6
Urinary tract	KU1919	5.5
Urinary tract	RT11284	5.4
Urinary tract	RT112	5
Urinary tract	RT4	5.3
Urinary tract	SCABER	5.4
Urinary tract	SW1710	5.8
Urinary tract	SW780	5.5
Urinary tract	T24	5.2
Urinary tract	TCCSUP	6.3
Urinary tract	UMUC1	6.2
Urinary tract	UMUC3	5.8
Urinary tract	VMCUB1	5.5

> The Human Protein Atlas (HPA)

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Tissue	Expression Level (TPM)
Adipose tissue	25.6
Adrenal gland	31.1
Appendix	15.1
Bone marrow	13.5
Breast	16.7
Cerebral cortex	37
Cervix, uterine	25.9
Colon	10.9
Duodenum	12.1
Endometrium	33.9
Epididymis	18.9
Esophagus	30.6
Fallopian tube	36.8
Gallbladder	24.6
Heart muscle	25
Kidney	11.6
Liver	4.5
Lung	28.7
Lymph node	15.7
Ovary	40
Pancreas	4.7
Parathyroid gland	59.2
Placenta	32.4
Prostate	22.5
Rectum	8.2
Salivary gland	8.9
Seminal vesicle	21.4
Skeletal muscle	23.5
Skin	57.5
Small intestine	15.6
Smooth muscle	22.2
Spleen	28.6
Stomach	12.3
Testis	27.9
Thyroid gland	22.6
Tonsil	11.2
Urinary bladder	19.4

> Text Mining based Expression

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PMID	Expression	Cancer	Evidence
27177225	Overexpression	Breast Carcinoma	HDAC5 was extensively expressed in human BC tissues, and high HDAC5 expression was associated with an inferior prognosis.
26993777	Overexpression	Hepatocellular Carcinoma	We found that HDAC5 was upregulated in HCC tissues compared to adjacent normal tissues, and this was correlated with reduced patient survival.
26747087	Overexpression	Melanoma	In this study, and found that HDAC5 and HDAC6 were highly expressed in melanoma cells but exhibited low expression levels in normal skin cells.
26131280	Overexpression	Colorectal Carcinoma	In the current research, our data showed that the mRNA and protein levels of HDAC5 were up-regulated in human colorectal cancer cell lines.
25791281	Underexpression	Glioma	Among all patients studied, the expression of HDAC1 and HDAC3 was inversely correlated with survival, whereas the expression of HDAC4, HDAC5, HDAC6, HDAC11 and SIRT1 was significantly and positively correlated with survival time of patients with gliomas.
25482492	Overexpression	Plasma Cell Myeloma	In HMCL, HDAC1-3 and 8 (Class I), and HDAC5 and HDAC10 (Class II) were significantly upregulated compared to normal PC.
25129440	Overexpression	Hepatocellular Carcinoma	The present study reported that the mRNA and protein levels of HDAC5 were up-regulated in human hepatocellular carcinoma (HCC) tissues and cells as shown by quantitative real-time PCR and Western blot.
25050565	Overexpression	Glioma	In the present study, we found that the mRNA and protein levels of HDAC5 are increased in human glioma tissues and cell lines. Taken together, these results demonstrated, for the first time to the best of our knowledge, that HDAC5 promotes glioma cell proliferation, and suggest that this effect involves the upregulation of Notch 1.
24706304	Overexpression	Hepatocellular Carcinoma	The mRNA and protein levels of HDAC5 were up-regulated in human HCC cell lines. The current study demonstrated for the first time that HDAC5 promoted HCC cell proliferation through up-regulation of Six1 expression and might provide novel therapeutic targets in the treatment of HCC.
24092570	Overexpression	Osteosarcoma	We found that mRNA and protein levels of HDAC5 were upregulated in osteosarcoma tissues and cell lines.
23724067	Overexpression	Colorectal Carcinoma	We found HDAC1, HDAC2, HDAC3, HDAC5, and HDAC7 all to be up-regulated in the field of human CRC.
22944197	Underexpression	Urothelial Carcinoma	In urothelial cancer, up-regulation of HDAC2 and HDAC8 and down-regulation of HDAC4, HDAC5, and HDAC7 mRNA are common findings.
22322234	Overexpression (copy number gain)	Hepatocellular Carcinoma	Upregulation of HDAC3 and HDAC5 mRNAs was significantly correlated with DNA copy number gains. Aberrant expression of several HDACs and copy number gains of HDAC3 and HDAC5 occur in HCC.
20636436	Overexpression	B Acute Lymphoblastic Leukemia	HDAC1 and HDAC4 showed high expression in T-ALL and HDAC5 was highly expressed in B-lineage ALL.
20559690	Overexpression	Gastric Carcinoma	Using cDNA microarray analysis, we found that hepatocyte growth factor (HGF) induced HDAC5 expression in gastric cancer cell lines, NUGC-3 and MKN-28.
20519629	Overexpression	Waldenstrom Macroglobulinemia	We found that restoring miRNA-9* levels induced toxicity in WM cells, supported by down-modulation of HDAC4 and HDAC5 and up-regulation of acetyl-histone-H3 and -H4.
20413433	Overexpression	Medulloblastoma	HDAC5 and HDAC9 are significantly upregulated in high-risk medulloblastoma in comparison with low-risk medulloblastoma, and their expression is associated with poor survival.
20128820	Overexpression	Pancreatic Carcinoma	Therefore, in some pancreatic cancers, continuous ORP5 expression enhances the cholesterol synthesis pathway and this signal transduction regulates phosphatase and tensin homolog through HDAC5 expression.
16121216	Underexpression	Acute Myeloid Leukemia	HDAC5 and SIRT4 were consistently underexpressed.
12124339	Underexpression	Colon Carcinoma	Quantitative real-time reverse transcription-PCR showed that the mRNA expression levels of 2 antigens, HDAC5 and Seb4B, were down-regulated in colon cancer, 2 other antigens, KNSL6 and KIAA1416, were up-regulated, and another antigen, NY-CO-45, showed a variable level of mRNA expression in colon cancer.
27212032	Overexpression	Breast Carcinoma	Here, we report that expression of HDAC5 and LSD1 proteins were positively correlated in human breast cancer cell lines and tissue specimens of primary breast tumors. Protein expression of HDAC5 and LSD1 was significantly increased in primary breast cancer specimens in comparison with matched-normal adjacent tissues.
28653891	Overexpression	Hepatocellular Carcinoma	Finally, clinical analysis confirmed the positive correlation between histone deacetylase 5 and hypoxia-inducible factor-1α in hepatocellular carcinoma specimens and a relatively poor prognosis for the patients with high levels of histone deacetylase 5 and hypoxia-inducible factor-1α.
28440397	Overexpression	Non-small Cell Lung Carcinoma	In the present study, aberrant high levels of HDAC5 were observed in non-small cell lung cancer (NSCLC) and further analysis indicated a negative relationship between HDAC5 and a tumor suppressor, miR5895p, in NSCLC specimens.
28235630	Overexpression	Pancreatic Neuroendocrine Carcinoma	Immunohistochemical profiling revealed a significant up-regulation of all HDAC classes in pNET versus control with different levels of intensity and extensity ranging from 1.5 to >7-fold up-regulation. Additionally, expression of several HDACs (HDAC-1, -2, -5, -11 and Sirt 1) was significantly increased in G3 tumors.
28077642	Overexpression	Ovarian Carcinoma; Lung Carcinoma	Here, we demonstrate, using patient biopsy specimens, that HD5 is also expressed as an active, secreted peptide by epithelial ovarian and lung cancer cells in situ This finding prompted us to study the role of HD5 in infection and spread of replication-competent, oncolytic HAdV type 3 (HAdV3).

Summary
Symbol	HDAC5
Name	histone deacetylase 5
Aliases	KIAA0600; NY-CO-9; FLJ90614; HD5; antigen NY-CO-9
Location	17q21.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

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Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.266	5.7e-08	8.9	54.2	36.9	Gain
BRCA	Breast invasive carcinoma	1075	0.486	7.59e-65	33.9	46.8	19.3	Loss
CESC	Cervical and endocervical cancers	292	0.162	0.00553	11.6	71.9	16.4	Neutral
COAD	Colon adenocarcinoma	449	0.276	2.9e-09	12.2	66.1	21.6	Neutral
ESCA	Esophageal carcinoma	183	0.313	1.59e-05	13.1	56.8	30.1	Neutral
GBM	Glioblastoma multiforme	147	0.185	0.0248	10.2	78.9	10.9	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.26	2.35e-09	7.2	75.7	17.1	Neutral
KIRC	Kidney renal clear cell carcinoma	525	-0.031	0.474	5.7	88.4	5.9	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.025	0.674	0.3	33.7	66	Gain
LAML	Acute Myeloid Leukemia	166	0.17	0.0289	3.6	94	2.4	Neutral
LGG	Brain Lower Grade Glioma	513	0.13	0.00323	3.3	92.6	4.1	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.369	3.58e-13	9.9	63.2	26.9	Neutral
LUAD	Lung adenocarcinoma	512	0.25	1.04e-08	7.2	49.8	43	Gain
LUSC	Lung squamous cell carcinoma	498	0.286	7.98e-11	21.1	46	32.9	Neutral
OV	Ovarian serous cystadenocarcinoma	300	0.583	1.01e-28	69.7	20	10.3	Loss
PAAD	Pancreatic adenocarcinoma	177	0.517	1.72e-13	8.5	77.4	14.1	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.493	2.75e-11	17.3	77.8	4.9	Neutral
PRAD	Prostate adenocarcinoma	491	0.353	6.99e-16	19.3	79.4	1.2	Neutral
READ	Rectum adenocarcinoma	164	0.302	8.72e-05	15.2	62.2	22.6	Neutral
SARC	Sarcoma	255	0.325	1.08e-07	21.6	56.5	22	Neutral
SKCM	Skin Cutaneous Melanoma	367	0.391	7.05e-15	19.9	61	19.1	Neutral
STAD	Stomach adenocarcinoma	413	0.287	2.96e-09	14	65.1	20.8	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.029	0.726	8	54.7	37.3	Gain
THCA	Thyroid carcinoma	497	0.227	3.19e-07	0.2	95.6	4.2	Neutral
THYM	Thymoma	119	0.319	0.000401	3.4	88.2	8.4	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.243	1.14e-08	19	72.8	8.2	Neutral

Summary
Symbol	HDAC5
Name	histone deacetylase 5
Aliases	KIAA0600; NY-CO-9; FLJ90614; HD5; antigen NY-CO-9
Location	17q21.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.153	0.00155	17	408	0.001	0.347	NS/NA
BRCA	Breast invasive carcinoma	-0.283	2.24e-17	83	785	0.177	1.51e-18	NS/NA
CESC	Cervical and endocervical cancers	-0.176	0.00194	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.16	0.00451	19	297	0	0.0229	NS/NA
ESCA	Esophageal carcinoma	-0.13	0.0702	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.418	0.000601	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.162	0.000161	20	522	0.162	6.91e-05	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.292	4.09e-08	24	319	-0.164	5.23e-08	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.156	0.00707	23	275	0	0.754	NS/NA
LAML	Acute Myeloid Leukemia	-0.101	0.192	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.298	3.24e-12	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.21	1.67e-05	41	373	0	0.25	NS/NA
LUAD	Lung adenocarcinoma	-0.085	0.0637	21	456	-0.008	0.0891	NS/NA
LUSC	Lung squamous cell carcinoma	-0.211	3.81e-05	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.55	0.133	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.222	0.00262	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.296	4.35e-05	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.181	2.79e-05	35	498	0.183	2.54e-12	NS/NA
READ	Rectum adenocarcinoma	-0.301	0.00231	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.282	3.59e-06	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.181	8.13e-05	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.27	1.33e-07	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.433	2.38e-08	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.357	6.75e-19	50	509	-0.05	0.000143	NS/NA
THYM	Thymoma	-0.375	2.42e-05	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.248	6.54e-08	34	431	0.141	1.77e-07	NS/NA

Summary
Symbol	HDAC5
Name	histone deacetylase 5
Aliases	KIAA0600; NY-CO-9; FLJ90614; HD5; antigen NY-CO-9
Location	17q21.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	2	Medium
Appendix	3	High
Bone marrow	3	High
Breast	2	Medium
Caudate	1	Low
Cerebellum	2	Medium
Cerebral cortex	2	Medium
Cervix, uterine	2	Medium
Colon	3	High
Duodenum	3	High
Endometrium	2	Medium
Epididymis	2	Medium
Esophagus	2	Medium
Fallopian tube	2	Medium
Gallbladder	2	Medium
Heart muscle	1	Low
Hippocampus	2	Medium
Kidney	2	Medium
Liver	2	Medium
Lung	2	Medium
Lymph node	2	Medium
Nasopharynx	2	Medium
Oral mucosa	2	Medium
Ovary	1	Low
Pancreas	2	Medium
Parathyroid gland	2	Medium
Placenta	2	Medium
Prostate	2	Medium
Rectum	2	Medium
Salivary gland	3	High
Seminal vesicle	2	Medium
Skeletal muscle	1	Low
Skin	3	High
Small intestine	2	Medium
Smooth muscle	2	Medium
Soft tissue	3	High
Spleen	2	Medium
Stomach	2	Medium
Testis	2	Medium
Thyroid gland	3	High
Tonsil	3	High
Urinary bladder	1	Low
Vagina	2	Medium

Summary
Symbol	HDAC5
Name	histone deacetylase 5
Aliases	KIAA0600; NY-CO-9; FLJ90614; HD5; antigen NY-CO-9
Location	17q21.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.0938	NS	24476821
BRCA	Breast invasive carcinoma	521	2.96e-13	Significant	23000897
COAD	Colon adenocarcinoma	149	7.62e-06	Significant	22810696
GBM	Glioblastoma multiforme	157	2.84e-05	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	0.0797	NS	25631445
KIRP	Kidney renal papillary cell carcinoma	161	2.24e-06	Significant	26536169
LGG	Brain Lower Grade Glioma	513	1.36e-22	Significant	26824661
LUAD	Lung adenocarcinoma	230	0.00576	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	0.322	NS	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.195	NS	21720365
PRAD	Prostate adenocarcinoma	333	0.623	NS	26544944
READ	Rectum adenocarcinoma	67	0.00043	Significant	22810696
SKCM	Skin Cutaneous Melanoma	315	0.00405	Significant	26091043
STAD	Stomach adenocarcinoma	277	9.94e-13	Significant	25079317
THCA	Thyroid carcinoma	391	0.52	NS	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.00182	Significant	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	1.525	0.0537	NS
BRCA	Breast invasive carcinoma	1079	1.089	0.688	NS
CESC	Cervical and endocervical cancers	291	0.754	0.431	NS
COAD	Colon adenocarcinoma	439	1.368	0.291	NS
ESCA	Esophageal carcinoma	184	0.872	0.685	NS
GBM	Glioblastoma multiforme	158	1.047	0.855	NS
HNSC	Head and Neck squamous cell carcinoma	518	0.782	0.228	NS
KIRC	Kidney renal clear cell carcinoma	531	0.545	0.00382	Longer
KIRP	Kidney renal papillary cell carcinoma	287	0.823	0.668	NS
LAML	Acute Myeloid Leukemia	149	1.373	0.265	NS
LGG	Brain Lower Grade Glioma	511	0.35	5.86e-05	Longer
LIHC	Liver hepatocellular carcinoma	365	1.533	0.0864	NS
LUAD	Lung adenocarcinoma	502	0.54	0.00465	Longer
LUSC	Lung squamous cell carcinoma	494	1.049	0.807	NS
OV	Ovarian serous cystadenocarcinoma	303	1.193	0.386	NS
PAAD	Pancreatic adenocarcinoma	177	0.461	0.00991	Longer
PCPG	Pheochromocytoma and Paraganglioma	179	0	0.288	NS
PRAD	Prostate adenocarcinoma	497	0.833	0.828	NS
READ	Rectum adenocarcinoma	159	0.957	0.938	NS
SARC	Sarcoma	259	1.141	0.636	NS
SKCM	Skin Cutaneous Melanoma	459	1.209	0.309	NS
STAD	Stomach adenocarcinoma	388	1.579	0.0552	NS
TGCT	Testicular Germ Cell Tumors	134	1.027	0.985	NS
THCA	Thyroid carcinoma	500	0.542	0.396	NS
THYM	Thymoma	119	4.539	0.179	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	0.978	0.939	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	0.077	0.121	NS
BRCA	Breast invasive carcinoma	1071	0.013	0.67	NS
CESC	Cervical and endocervical cancers	167	0.148	0.0555	NS
COAD	Colon adenocarcinoma	445	0.195	3.47e-05	Higher
ESCA	Esophageal carcinoma	162	-0.05	0.53	NS
HNSC	Head and Neck squamous cell carcinoma	448	0.058	0.222	NS
KIRC	Kidney renal clear cell carcinoma	531	-0.199	3.89e-06	Lower
KIRP	Kidney renal papillary cell carcinoma	260	0.184	0.00284	Higher
LIHC	Liver hepatocellular carcinoma	347	0.064	0.233	NS
LUAD	Lung adenocarcinoma	507	-0.068	0.125	NS
LUSC	Lung squamous cell carcinoma	497	-0.025	0.584	NS
OV	Ovarian serous cystadenocarcinoma	302	-0.017	0.769	NS
PAAD	Pancreatic adenocarcinoma	176	-0.08	0.293	NS
READ	Rectum adenocarcinoma	156	0.129	0.109	NS
SKCM	Skin Cutaneous Melanoma	410	-0.061	0.216	NS
STAD	Stomach adenocarcinoma	392	-0.036	0.482	NS
TGCT	Testicular Germ Cell Tumors	81	-0.241	0.0303	Lower
THCA	Thyroid carcinoma	499	0.097	0.0297	Higher
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.094	0.0355	Higher

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	-0.032	0.602	NS
HNSC	Head and Neck squamous cell carcinoma	498	0.036	0.419	NS
KIRC	Kidney renal clear cell carcinoma	525	-0.232	7.11e-08	Lower
LGG	Brain Lower Grade Glioma	514	-0.155	0.00042	Lower
LIHC	Liver hepatocellular carcinoma	366	0.059	0.261	NS
OV	Ovarian serous cystadenocarcinoma	296	-0.021	0.72	NS
PAAD	Pancreatic adenocarcinoma	176	-0.106	0.162	NS
STAD	Stomach adenocarcinoma	406	0.028	0.57	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.076	0.0791	NS

Summary
Symbol	HDAC5
Name	histone deacetylase 5
Aliases	KIAA0600; NY-CO-9; FLJ90614; HD5; antigen NY-CO-9
Location	17q21.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	HDAC5
Name	histone deacetylase 5
Aliases	KIAA0600; NY-CO-9; FLJ90614; HD5; antigen NY-CO-9
Location	17q21.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database

[ TOP ]

DrugBank ID	Name	Type	All Targets
DB05015	Belinostat	Small Molecule Drug
DB06603	Panobinostat	Small Molecule Drug

Summary
Symbol	HDAC5
Name	histone deacetylase 5
Aliases	KIAA0600; NY-CO-9; FLJ90614; HD5; antigen NY-CO-9
Location	17q21.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
26993777	Hepatocellular Carcinoma	upstream	AR-42	Negative regulation	We demonstrated that AR-42 can inhibit the deacetylation activity of HDAC5 and its downstream targets in vitro and in vivo.
26131280	Colorectal Carcinoma	downstream	DLL4	Positive regulation	At the molecular level, we demonstrated that HDAC5 promoted the expression of DLL4.
25050565	Glioma	downstream	Notch1	Positive regulation	Furthermore, we demonstrated that HDAC5 enhances Notch 1 expression at both the mRNA and the protein level in glioma cell lines. Taken together, these results demonstrated, for the first time to the best of our knowledge, that HDAC5 promotes glioma cell proliferation, and suggest that this effect involves the upregulation of Notch 1.
24706304	Hepatocellular Carcinoma	downstream	Six1	Positive regulation	Furthermore, we found that HDAC5 promoted the Six1 expression both at the mRNA and protein levels in HCC cell lines. The current study demonstrated for the first time that HDAC5 promoted HCC cell proliferation through up-regulation of Six1 expression and might provide novel therapeutic targets in the treatment of HCC.
24092570	Osteosarcoma	downstream	Twist 1	Positive regulation	At the molecular level, we demonstrated that HDAC5 promoted mRNA expression of twist 1, which has been reported as an oncogene.
20559690	Gastric Carcinoma	upstream	HGF; GO6976	Positive regulation; Negative regulation	Using cDNA microarray analysis, we found that hepatocyte growth factor (HGF) induced HDAC5 expression in gastric cancer cell lines, NUGC-3 and MKN-28. Furthermore, GO6976, a PKC inhibitor, significantly inhibited not only HGF-induced HDAC5 expression but also cell invasion.
20519629	Waldenstrom Macroglobulinemia	partner	miRNA-9*	Negative correlation	We found that restoring miRNA-9* levels induced toxicity in WM cells, supported by down-modulation of HDAC4 and HDAC5 and up-regulation of acetyl-histone-H3 and -H4.
20128820	Pancreatic Carcinoma	upstream	SREBP2	Regulation	ChIP using SREBP2 antibody revealed that histone deacetylase 5 (HDAC5) was one of the downstream genes of SREBP2.
27212032	Breast Carcinoma	partner	LSD1	Binding	Using HDAC5 deletion mutants and co-immunoprecipitation studies, we showed that HDAC5 physically interacted with the LSD1 complex through its domain containing nuclear localization sequence and phosphorylation sites.
27212032	Breast Carcinoma	downstream	LSD1; USP28	Positive regulation	Here, we report that expression of HDAC5 and LSD1 proteins were positively correlated in human breast cancer cell lines and tissue specimens of primary breast tumors. Overexpression of USP28 largely reversed HDAC5-KD-induced LSD1 protein degradation, suggesting a role of HDAC5 as a positive regulator of LSD1 through upregulation of USP28 protein.
28653891	Hepatocellular Carcinoma	partner	HIF-1α	Positive correlation	Finally, clinical analysis confirmed the positive correlation between histone deacetylase 5 and hypoxia-inducible factor-1α in hepatocellular carcinoma specimens and a relatively poor prognosis for the patients with high levels of histone deacetylase 5 and hypoxia-inducible factor-1α.
28440397	Non-small Cell Lung Carcinoma	upstream	miR-589-5p	Negative regulation	Hypermethylation of miRNA-589 promoter leads to upregulation of HDAC5 which promotes malignancy in non-small cell lung cancer. Consistently, miR5895p reduced the expression of HDAC5 by targeting the 3'UTR of HDAC5 mRNA in NSCLC cells.