CR2Cancer

Summary
Symbol	HDAC8
Name	histone deacetylase 8
Aliases	HDACL1; MRXS6; histone deacetylase-like 1; Wilson-Turner X-linked mental retardation syndrome; CDA07; CDLS5; ......
Location	Xq13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

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Domain

PF00850 Histone deacetylase domain

Function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility.

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification erase	Histone acetylation	H2AKac, H2BKac, H3Kac, H4Kac	H2AK, H2BK, H3K, H4K	10748112

> Gene Ontology [ TOP ]
Biological Process	GO:0000723 telomere maintenance GO:0000819 sister chromatid segregation GO:0006333 chromatin assembly or disassembly GO:0006476 protein deacetylation GO:0007059 chromosome segregation GO:0007062 sister chromatid cohesion GO:0007063 regulation of sister chromatid cohesion GO:0016570 histone modification GO:0016575 histone deacetylation GO:0031396 regulation of protein ubiquitination GO:0031397 negative regulation of protein ubiquitination GO:0031647 regulation of protein stability GO:0032200 telomere organization GO:0032204 regulation of telomere maintenance GO:0032844 regulation of homeostatic process GO:0033044 regulation of chromosome organization GO:0033045 regulation of sister chromatid segregation GO:0034085 establishment of sister chromatid cohesion GO:0034502 protein localization to chromosome GO:0035601 protein deacylation GO:0043388 positive regulation of DNA binding GO:0051052 regulation of DNA metabolic process GO:0051098 regulation of binding GO:0051099 positive regulation of binding GO:0051101 regulation of DNA binding GO:0051983 regulation of chromosome segregation GO:0060249 anatomical structure homeostasis GO:0070932 histone H3 deacetylation GO:0071168 protein localization to chromatin GO:0071921 cohesin loading GO:0071922 regulation of cohesin loading GO:0098732 macromolecule deacylation GO:0098813 nuclear chromosome segregation GO:1903320 regulation of protein modification by small protein conjugation or removal GO:1903321 negative regulation of protein modification by small protein conjugation or removal
Molecular Function	GO:0004407 histone deacetylase activity GO:0008134 transcription factor binding GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides GO:0017136 NAD-dependent histone deacetylase activity GO:0019213 deacetylase activity GO:0030544 Hsp70 protein binding GO:0031072 heat shock protein binding GO:0031078 histone deacetylase activity (H3-K14 specific) GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific) GO:0033558 protein deacetylase activity GO:0034979 NAD-dependent protein deacetylase activity GO:0051879 Hsp90 protein binding
Cellular Component	GO:0000118 histone deacetylase complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-1640170: Cell Cycle R-HSA-69278: Cell Cycle, Mitotic R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-2894862: Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2644606: Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-1643685: Disease R-HSA-5663202: Diseases of signal transduction R-HSA-3214815: HDACs deacetylate histones R-HSA-68886: M Phase R-HSA-68882: Mitotic Anaphase R-HSA-2555396: Mitotic Metaphase and Anaphase R-HSA-68877: Mitotic Prometaphase R-HSA-2122947: NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2500257: Resolution of Sister Chromatid Cohesion R-HSA-2467813: Separation of Sister Chromatids R-HSA-162582: Signal Transduction R-HSA-157118: Signaling by NOTCH R-HSA-1980143: Signaling by NOTCH1 R-HSA-2894858: Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2644602: Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644603: Signaling by NOTCH1 in Cancer

> KEGG and Reactome Pathway

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KEGG

Reactome

R-HSA-1640170: Cell Cycle
R-HSA-69278: Cell Cycle, Mitotic
R-HSA-3247509: Chromatin modifying enzymes
R-HSA-4839726: Chromatin organization
R-HSA-2894862: Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
R-HSA-2644606: Constitutive Signaling by NOTCH1 PEST Domain Mutants
R-HSA-1643685: Disease
R-HSA-5663202: Diseases of signal transduction
R-HSA-3214815: HDACs deacetylate histones
R-HSA-68886: M Phase
R-HSA-68882: Mitotic Anaphase
R-HSA-2555396: Mitotic Metaphase and Anaphase
R-HSA-68877: Mitotic Prometaphase
R-HSA-2122947: NOTCH1 Intracellular Domain Regulates Transcription
R-HSA-2500257: Resolution of Sister Chromatid Cohesion
R-HSA-2467813: Separation of Sister Chromatids
R-HSA-162582: Signal Transduction
R-HSA-157118: Signaling by NOTCH
R-HSA-1980143: Signaling by NOTCH1
R-HSA-2894858: Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
R-HSA-2644602: Signaling by NOTCH1 PEST Domain Mutants in Cancer
R-HSA-2644603: Signaling by NOTCH1 in Cancer

Summary
Symbol	HDAC8
Name	histone deacetylase 8
Aliases	HDACL1; MRXS6; histone deacetylase-like 1; Wilson-Turner X-linked mental retardation syndrome; CDA07; CDLS5; ......
Location	Xq13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]

> Catalogue of Somatic Mutations in Cancer (COSMIC)

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COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM1469305	c.506T>G	p.F169C	Substitution - Missense	Large_intestine
COSM1125085	c.667C>T	p.R223W	Substitution - Missense	Large_intestine
COSM3096220	c.978A>G	p.T326T	Substitution - coding silent	Pancreas
COSM4110981	c.1127T>C	p.V376A	Substitution - Missense	Stomach
COSM1125084	c.1047G>A	p.T349T	Substitution - coding silent	Endometrium
COSM5591237	c.268C>T	p.H90Y	Substitution - Missense	Skin
COSM3783623	c.707A>G	p.Q236R	Substitution - Missense	Prostate
COSM5619481	c.159G>A	p.Q53Q	Substitution - coding silent	Breast
COSM5891263	c.694C>T	p.Q232*	Substitution - Nonsense	Skin
COSM3940108	c.997G>A	p.D333N	Substitution - Missense	Oesophagus
COSM5910008	c.544G>A	p.G182R	Substitution - Missense	Skin
COSM5642956	c.629-1G>C	p.?	Unknown	Oesophagus
COSM3096254	c.259G>T	p.D87Y	Substitution - Missense	Pancreas
COSM3563247	c.817C>T	p.P273S	Substitution - Missense	Skin
COSM3096255	c.258C>T	p.G86G	Substitution - coding silent	Oesophagus
COSM3096259	c.91C>T	p.L31L	Substitution - coding silent	Large_intestine
COSM1491268	c.937C>T	p.R313*	Substitution - Nonsense	Skin
COSM1125083	c.1057C>T	p.R353W	Substitution - Missense	Endometrium
COSM5768933	c.349G>T	p.G117W	Substitution - Missense	Breast
COSM458028	c.463C>G	p.L155V	Substitution - Missense	Breast
COSM3372328	c.1000C>T	p.H334Y	Substitution - Missense	Thyroid
COSM4621750	c.90C>T	p.S30S	Substitution - coding silent	Large_intestine
COSM5422542	c.129T>G	p.S43S	Substitution - coding silent	Prostate
COSM4840690	c.170T>G	p.V57G	Substitution - Missense	Cervix
COSM1331699	c.146C>T	p.A49V	Substitution - Missense	Ovary
COSM3914219	c.712G>A	p.E238K	Substitution - Missense	Skin
COSM458027	c.932C>T	p.T311M	Substitution - Missense	Breast
COSM5423375	c.76A>C	p.S26R	Substitution - Missense	Prostate
COSM5413063	c.1024C>T	p.P342S	Substitution - Missense	Skin
COSM458026	c.1106T>A	p.I369N	Substitution - Missense	Breast
COSM5897252	c.827C>T	p.S276F	Substitution - Missense	Skin
COSM1125085	c.667C>T	p.R223W	Substitution - Missense	Endometrium
COSM3563249	c.624C>T	p.F208F	Substitution - coding silent	Skin
COSM311727	c.817C>A	p.P273T	Substitution - Missense	Soft_tissue
COSM757606	c.733G>T	p.E245*	Substitution - Nonsense	Lung
COSM4110983	c.423G>A	p.W141*	Substitution - Nonsense	Stomach
COSM2155917	c.561C>T	p.D187D	Substitution - coding silent	Central_nervous_system
COSM4655014	c.500G>A	p.R167Q	Substitution - Missense	Large_intestine
COSM3563246	c.995C>A	p.P332Q	Substitution - Missense	Skin
COSM4608101	c.890C>A	p.A297E	Substitution - Missense	Adrenal_gland
COSM3563248	c.783C>T	p.V261V	Substitution - coding silent	Skin
COSM311727	c.817C>A	p.P273T	Substitution - Missense	Lung
COSM3800745	c.67G>A	p.E23K	Substitution - Missense	Urinary_tract
COSM5346046	c.217G>A	p.D73N	Substitution - Missense	Large_intestine
COSM1125086	c.522C>T	p.Y174Y	Substitution - coding silent	Endometrium
COSM3563258	c.427C>T	p.H143Y	Substitution - Missense	Skin
COSM5911127	c.368C>G	p.A123G	Substitution - Missense	Skin
COSM3096255	c.258C>T	p.G86G	Substitution - coding silent	Stomach
COSM5472916	c.1067G>A	p.R356H	Substitution - Missense	Large_intestine
COSM458027	c.932C>T	p.T311M	Substitution - Missense	Stomach
COSM462183	c.567C>G	p.F189L	Substitution - Missense	Cervix
COSM5977562	c.17_18insGCCGGAGGA	p.P7_A8insEEP	Insertion - In frame	Upper_aerodigestive_tract
COSM1132264	c.431C>G	p.A144G	Substitution - Missense	Prostate
COSM4934816	c.221C>G	p.A74G	Substitution - Missense	Liver
COSM3845342	c.867G>A	p.K289K	Substitution - coding silent	Breast
COSM4689715	c.490C>T	p.R164*	Substitution - Nonsense	Large_intestine
COSM3563245	c.1112G>A	p.G371E	Substitution - Missense	Skin
COSM367777	c.132G>T	p.L44F	Substitution - Missense	Lung
COSM1125085	c.667C>T	p.R223W	Substitution - Missense	Large_intestine
COSM3424941	c.1008T>G	p.F336L	Substitution - Missense	Large_intestine
COSM3096255	c.258C>T	p.G86G	Substitution - coding silent	Oesophagus
COSM4757244	c.341C>T	p.A114V	Substitution - Missense	Stomach
COSM4689717	c.1A>C	p.M1L	Substitution - Missense	Large_intestine

> Text Mining based Variations [ TOP ]
There is no record for HDAC8.

Summary
Symbol	HDAC8
Name	histone deacetylase 8
Aliases	HDACL1; MRXS6; histone deacetylase-like 1; Wilson-Turner X-linked mental retardation syndrome; CDA07; CDLS5; ......
Location	Xq13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

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Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant

Summary
Symbol	HDAC8
Name	histone deacetylase 8
Aliases	HDACL1; MRXS6; histone deacetylase-like 1; Wilson-Turner X-linked mental retardation syndrome; CDA07; CDLS5; ......
Location	Xq13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

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Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	3.606	4.165	0.486	3.02e-05	NS
BRCA	Breast invasive carcinoma	112	1100	3.62	4.009	0.401	1.71e-18	NS
CESC	Cervical and endocervical cancers	3	306	3.815	4.337	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	3.3	3.976	0.72	3.22e-20	Over
ESCA	Esophageal carcinoma	11	185	3.399	3.701	0.295	0.07	NS
GBM	Glioblastoma multiforme	5	166	3.693	3.826	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	3.241	3.503	0.24	0.00159	NS
KIRC	Kidney renal clear cell carcinoma	72	534	3.901	3.553	-0.279	1.76e-09	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	3.837	3.926	0.11	0.171	NS
LAML	Acute Myeloid Leukemia	0	173	NA	4.265	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	3.806	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	3.342	3.485	0.234	0.00519	NS
LUAD	Lung adenocarcinoma	59	517	3.604	3.943	0.353	1.18e-08	NS
LUSC	Lung squamous cell carcinoma	51	501	3.456	3.742	0.266	0.000101	NS
OV	Ovarian serous cystadenocarcinoma	0	307	NA	3.81	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	3.645	3.695	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	4.803	4.32	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	3.855	4.193	0.368	1.63e-12	NS
READ	Rectum adenocarcinoma	10	167	3.253	4.029	0.75	2.06e-05	Over
SARC	Sarcoma	2	263	4.065	3.97	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	3.164	3.743	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	3.235	3.647	0.449	2.29e-07	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	3.776	NA	NA	NA
THCA	Thyroid carcinoma	59	509	4.026	4.321	0.3	7.4e-10	NS
THYM	Thymoma	2	120	3.473	4.009	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	3.799	4.405	0.549	5.52e-12	NS

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

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Tissue	Expression Level (TPM)
Adipose tissue	9.3
Adrenal gland	20.9
Appendix	12.1
Bone marrow	6.2
Breast	12.4
Cerebral cortex	15.7
Cervix, uterine	14.6
Colon	8.8
Duodenum	7.4
Endometrium	13.7
Epididymis	26.9
Esophagus	8.3
Fallopian tube	12.1
Gallbladder	12.2
Heart muscle	6.9
Kidney	14.4
Liver	8
Lung	12.8
Lymph node	10.3
Ovary	12.1
Pancreas	1.7
Parathyroid gland	16.8
Placenta	13.4
Prostate	17.1
Rectum	11.6
Salivary gland	4.6
Seminal vesicle	11
Skeletal muscle	3
Skin	9.3
Small intestine	7.3
Smooth muscle	15.6
Spleen	9.7
Stomach	8.5
Testis	5.7
Thyroid gland	20.4
Tonsil	9.7
Urinary bladder	10.6

> Text Mining based Expression

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PMID	Expression	Cancer	Evidence
20636436	Overexpression	Acute Lymphoid Leukemia	ALL samples showed higher expression levels of HDAC2, HDAC3, HDAC8, HDAC6 and HDAC7 when compared to normal bone marrow samples.
26926079	Overexpression	Breast Carcinoma	HDAC8 mRNA expression was upregulated in paired breast cancer tissue from Taiwanese patients and in paired breast cancer tissues from the TCGA data set. Hypomethylation of promoter regions was significantly correlated with HDAC8 mRNA overexpression in 588 breast cancer patients from the TCGA data set and was associated with poor prognosis in early-stage breast cancer.
26412386	Overexpression	Gastric Carcinoma	We found that the expression of HDAC8 was significantly upregulated both in GC cell lines and tumor tissues compared to human normal gastric epithelial cell, GES-1 and matched non-tumor tissues.
25836739	Overexpression	Melanoma	HDAC8 was increased in BRAF-mutated melanoma (P=0.016), however, no association between expression of other HDACs and NRAS/BRAF status was identified.
24077923	Overexpression	Hepatocellular Carcinoma	Our results showed that expression of HDAC8 was significantly up-regulated both in HCC cell lines and tumor tissues compared to human normal liver cell line LO2 and corresponding non-tumor tissues.
19118036	Overexpression	Neuroblastoma	High HDAC8 expression was associated with poor prognostic markers and poor overall and event-free survival.
22944197	Overexpression	Urothelial Carcinoma	In cancer tissues, HDAC8 was likewise significantly up-regulated (P = 0.002), whereas HDAC2 up-regulation was detected only in a subset of tumors (9/24, P = 0.085).
27283490	Overexpression	Hepatocellular Carcinoma	We then found that the expression of both AHR and HDAC8 was significantly upregulated in both HCC cell lines and tumor tissues compared to human normal hepatocytes and matched non-tumor tissues.
28004115	Overexpression	Oesophagal Squamous Cell Carcinoma	HDAC8 were overexpressed in OSCC tissues and OSCC cells, mainly localized in the cytoplasm.

Summary
Symbol	HDAC8
Name	histone deacetylase 8
Aliases	HDACL1; MRXS6; histone deacetylase-like 1; Wilson-Turner X-linked mental retardation syndrome; CDA07; CDLS5; ......
Location	Xq13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

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Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.236	1.69e-06	20	66.6	13.4	Neutral
BRCA	Breast invasive carcinoma	1075	0.101	0.000864	18.7	67.5	13.8	Neutral
CESC	Cervical and endocervical cancers	292	0.218	0.000168	22.3	66.4	11.3	Neutral
COAD	Colon adenocarcinoma	449	0.04	0.392	12.5	70.8	16.7	Neutral
ESCA	Esophageal carcinoma	183	0.349	1.3e-06	18	55.2	26.8	Neutral
GBM	Glioblastoma multiforme	147	-0.017	0.838	24.5	69.4	6.1	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.193	1.04e-05	15.4	64.8	19.8	Neutral
KIRC	Kidney renal clear cell carcinoma	525	-0.104	0.0166	9.9	85.7	4.4	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.019	0.748	10.4	54.9	34.7	Gain
LAML	Acute Myeloid Leukemia	166	-0.074	0.346	3.6	95.8	0.6	Neutral
LGG	Brain Lower Grade Glioma	513	0.115	0.00913	13.3	76.2	10.5	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.394	5.53e-15	20.9	61.8	17.3	Neutral
LUAD	Lung adenocarcinoma	512	0.263	1.56e-09	16.8	69.5	13.7	Neutral
LUSC	Lung squamous cell carcinoma	498	0.218	9.29e-07	25.3	59.6	15.1	Neutral
OV	Ovarian serous cystadenocarcinoma	300	0.315	2.5e-08	37.7	31	31.3	Loss
PAAD	Pancreatic adenocarcinoma	177	-0.053	0.487	11.9	80.8	7.3	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.003	0.974	29.6	67.3	3.1	Neutral
PRAD	Prostate adenocarcinoma	491	-0.112	0.0132	6.3	90.8	2.9	Neutral
READ	Rectum adenocarcinoma	164	0.266	0.000566	17.7	62.8	19.5	Neutral
SARC	Sarcoma	255	0.255	3.91e-05	34.1	43.1	22.7	Loss
SKCM	Skin Cutaneous Melanoma	367	0.033	0.524	23.7	60.8	15.5	Neutral
STAD	Stomach adenocarcinoma	413	0.226	3.52e-06	13.8	73.8	12.3	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.043	0.605	18.7	64.7	16.7	Neutral
THCA	Thyroid carcinoma	497	-0.099	0.0276	0.8	97.6	1.6	Neutral
THYM	Thymoma	119	0.112	0.224	5	93.3	1.7	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.181	2.54e-05	11.4	72.8	15.8	Neutral

Summary
Symbol	HDAC8
Name	histone deacetylase 8
Aliases	HDACL1; MRXS6; histone deacetylase-like 1; Wilson-Turner X-linked mental retardation syndrome; CDA07; CDLS5; ......
Location	Xq13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

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Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.316	3.3e-11	17	408	-0.239	0.000491	Decreased
BRCA	Breast invasive carcinoma	-0.302	1.17e-19	83	785	-0.163	3.88e-46	NS/NA
CESC	Cervical and endocervical cancers	-0.134	0.0187	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.336	1.19e-09	19	297	-0.096	0.0118	NS/NA
ESCA	Esophageal carcinoma	-0.456	3.32e-11	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.147	0.243	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.353	1.74e-17	20	522	-0.002	0.185	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.127	0.0183	24	319	0.194	0.000664	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.161	0.00529	23	275	-0.008	0.459	NS/NA
LAML	Acute Myeloid Leukemia	-0.088	0.255	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.149	0.000576	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.22	6.83e-06	41	373	-0.006	0.0332	NS/NA
LUAD	Lung adenocarcinoma	-0.157	0.00059	21	456	0.016	0.518	NS/NA
LUSC	Lung squamous cell carcinoma	-0.188	0.000248	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.467	0.213	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.061	0.409	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.136	0.0636	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.248	7.56e-09	35	498	-0.014	1.07e-08	NS/NA
READ	Rectum adenocarcinoma	-0.281	0.00456	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.276	5.84e-06	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.157	0.000617	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.29	1.45e-08	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.284	0.000349	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.089	0.0353	50	509	-0.015	0.508	NS/NA
THYM	Thymoma	-0.166	0.0675	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.221	1.51e-06	34	431	-0.191	2.52e-37	NS/NA

Summary
Symbol	HDAC8
Name	histone deacetylase 8
Aliases	HDACL1; MRXS6; histone deacetylase-like 1; Wilson-Turner X-linked mental retardation syndrome; CDA07; CDLS5; ......
Location	Xq13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	3	High
Appendix	2	Medium
Bone marrow	3	High
Breast	2	Medium
Bronchus	0	Not detected
Caudate	0	Not detected
Cerebellum	1	Low
Cerebral cortex	2	Medium
Cervix, uterine	0	Not detected
Colon	2	Medium
Duodenum	2	Medium
Endometrium	2	Medium
Epididymis	2	Medium
Esophagus	2	Medium
Fallopian tube	2	Medium
Gallbladder	2	Medium
Heart muscle	2	Medium
Hippocampus	2	Medium
Kidney	2	Medium
Liver	2	Medium
Lung	2	Medium
Lymph node	2	Medium
Nasopharynx	0	Not detected
Oral mucosa	2	Medium
Ovary	2	Medium
Pancreas	3	High
Placenta	2	Medium
Prostate	2	Medium
Rectum	2	Medium
Salivary gland	3	High
Seminal vesicle	2	Medium
Skeletal muscle	2	Medium
Skin	2	Medium
Small intestine	2	Medium
Smooth muscle	2	Medium
Soft tissue	1	Low
Spleen	1	Low
Stomach	2	Medium
Testis	2	Medium
Thyroid gland	3	High
Tonsil	3	High
Urinary bladder	2	Medium
Vagina	2	Medium

Summary
Symbol	HDAC8
Name	histone deacetylase 8
Aliases	HDACL1; MRXS6; histone deacetylase-like 1; Wilson-Turner X-linked mental retardation syndrome; CDA07; CDLS5; ......
Location	Xq13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.068	NS	24476821
BRCA	Breast invasive carcinoma	521	0.132	NS	23000897
COAD	Colon adenocarcinoma	149	0.0151	Significant	22810696
GBM	Glioblastoma multiforme	157	0.00962	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	0.204	NS	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.134	NS	26536169
LGG	Brain Lower Grade Glioma	513	4.12e-08	Significant	26824661
LUAD	Lung adenocarcinoma	230	0.225	NS	25079552
LUSC	Lung squamous cell carcinoma	178	0.0263	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.00701	Significant	21720365
PRAD	Prostate adenocarcinoma	333	0.493	NS	26544944
READ	Rectum adenocarcinoma	67	0.523	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.0508	NS	26091043
STAD	Stomach adenocarcinoma	277	0.00261	Significant	25079317
THCA	Thyroid carcinoma	391	0.237	NS	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.0779	NS	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	0.713	0.105	NS
BRCA	Breast invasive carcinoma	1079	1.127	0.623	NS
CESC	Cervical and endocervical cancers	291	0.475	0.0439	Longer
COAD	Colon adenocarcinoma	439	0.907	0.735	NS
ESCA	Esophageal carcinoma	184	2.171	0.0208	Shorter
GBM	Glioblastoma multiforme	158	1.013	0.964	NS
HNSC	Head and Neck squamous cell carcinoma	518	1.317	0.168	NS
KIRC	Kidney renal clear cell carcinoma	531	2.478	3.27e-05	Shorter
KIRP	Kidney renal papillary cell carcinoma	287	1.104	0.814	NS
LAML	Acute Myeloid Leukemia	149	0.753	0.302	NS
LGG	Brain Lower Grade Glioma	511	0.58	0.0253	Longer
LIHC	Liver hepatocellular carcinoma	365	0.83	0.453	NS
LUAD	Lung adenocarcinoma	502	1.038	0.865	NS
LUSC	Lung squamous cell carcinoma	494	0.882	0.512	NS
OV	Ovarian serous cystadenocarcinoma	303	1.161	0.47	NS
PAAD	Pancreatic adenocarcinoma	177	0.855	0.604	NS
PCPG	Pheochromocytoma and Paraganglioma	179	579217898.339	0.324	NS
PRAD	Prostate adenocarcinoma	497	0.842	0.865	NS
READ	Rectum adenocarcinoma	159	1.26	0.673	NS
SARC	Sarcoma	259	1.437	0.207	NS
SKCM	Skin Cutaneous Melanoma	459	0.545	0.00134	Longer
STAD	Stomach adenocarcinoma	388	0.556	0.0155	Longer
TGCT	Testicular Germ Cell Tumors	134	0	0.27	NS
THCA	Thyroid carcinoma	500	0.236	0.0447	Longer
THYM	Thymoma	119	2.37	0.317	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	1.204	0.496	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	-0.037	0.462	NS
BRCA	Breast invasive carcinoma	1071	-0.012	0.685	NS
CESC	Cervical and endocervical cancers	167	0	0.999	NS
COAD	Colon adenocarcinoma	445	0.035	0.461	NS
ESCA	Esophageal carcinoma	162	0.14	0.0759	NS
HNSC	Head and Neck squamous cell carcinoma	448	0.039	0.413	NS
KIRC	Kidney renal clear cell carcinoma	531	0.198	4.26e-06	Higher
KIRP	Kidney renal papillary cell carcinoma	260	0.009	0.891	NS
LIHC	Liver hepatocellular carcinoma	347	0.01	0.85	NS
LUAD	Lung adenocarcinoma	507	0.032	0.476	NS
LUSC	Lung squamous cell carcinoma	497	0.014	0.753	NS
OV	Ovarian serous cystadenocarcinoma	302	0.009	0.874	NS
PAAD	Pancreatic adenocarcinoma	176	-0.123	0.105	NS
READ	Rectum adenocarcinoma	156	-0.025	0.752	NS
SKCM	Skin Cutaneous Melanoma	410	0.024	0.622	NS
STAD	Stomach adenocarcinoma	392	-0.098	0.0518	NS
TGCT	Testicular Germ Cell Tumors	81	0.27	0.0149	Higher
THCA	Thyroid carcinoma	499	0.051	0.255	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.004	0.929	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	0.04	0.508	NS
HNSC	Head and Neck squamous cell carcinoma	498	0.081	0.0701	NS
KIRC	Kidney renal clear cell carcinoma	525	0.249	7.64e-09	Higher
LGG	Brain Lower Grade Glioma	514	0.023	0.602	NS
LIHC	Liver hepatocellular carcinoma	366	-0.052	0.322	NS
OV	Ovarian serous cystadenocarcinoma	296	0.048	0.415	NS
PAAD	Pancreatic adenocarcinoma	176	-0.048	0.527	NS
STAD	Stomach adenocarcinoma	406	-0.186	0.00016	Lower
UCEC	Uterine Corpus Endometrial Carcinoma	534	-0.021	0.636	NS

Summary
Symbol	HDAC8
Name	histone deacetylase 8
Aliases	HDACL1; MRXS6; histone deacetylase-like 1; Wilson-Turner X-linked mental retardation syndrome; CDA07; CDLS5; ......
Location	Xq13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	HDAC8
Name	histone deacetylase 8
Aliases	HDACL1; MRXS6; histone deacetylase-like 1; Wilson-Turner X-linked mental retardation syndrome; CDA07; CDLS5; ......
Location	Xq13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database

[ TOP ]

DrugBank ID	Name	Type
DB02546	Vorinostat	Small Molecule Drug
DB02565	4-Dimethylamino-N-(6-Hydroxycarbamoyethyl)Benzamide-N-Hydroxy-7-(4-Dimethyla Minobenzoyl)Aminoheptanamide	Small Molecule Drug
DB02917	N-Hydroxy-4-(Methyl{[5-(2-Pyridinyl)-2-Thienyl]Sulfonyl}Amino)Benzamide	Small Molecule Drug
DB04297	7-[4-(Dimethylamino)Phenyl]-N-Hydroxy-4,6-Dimethyl-7-Oxo-2,4-Heptadienamide	Small Molecule Drug
DB07350	(2E)-N-hydroxy-3-[1-methyl-4-(phenylacetyl)-1H-pyrrol-2-yl]prop-2-enamide	Small Molecule Drug
DB07586	5-(4-METHYL-BENZOYLAMINO)-BIPHENYL-3,4'-DICARBOXYLIC ACID 3-DIMETHYLAMIDE-4'-HYDROXYAMIDE	Small Molecule Drug
DB08168	7-AMINO-4-METHYL-CHROMEN-2-ONE	Small Molecule Drug
DB05015	Belinostat	Small Molecule Drug
DB06603	Panobinostat	Small Molecule Drug
DB02546	Vorinostat	Small Molecule Drug
DB02565	4-Dimethylamino-N-(6-Hydroxycarbamoyethyl)Benzamide-N-Hydroxy-7-(4-Dimethyla Minobenzoyl)Aminoheptanamide	Small Molecule Drug
DB02917	N-Hydroxy-4-(Methyl{[5-(2-Pyridinyl)-2-Thienyl]Sulfonyl}Amino)Benzamide	Small Molecule Drug
DB04297	7-[4-(Dimethylamino)Phenyl]-N-Hydroxy-4,6-Dimethyl-7-Oxo-2,4-Heptadienamide	Small Molecule Drug
DB07350	(2E)-N-hydroxy-3-[1-methyl-4-(phenylacetyl)-1H-pyrrol-2-yl]prop-2-enamide	Small Molecule Drug
DB07586	5-(4-METHYL-BENZOYLAMINO)-BIPHENYL-3,4'-DICARBOXYLIC ACID 3-DIMETHYLAMIDE-4'-HYDROXYAMIDE	Small Molecule Drug
DB08168	7-AMINO-4-METHYL-CHROMEN-2-ONE	Small Molecule Drug
DB05015	Belinostat	Small Molecule Drug
DB06603	Panobinostat	Small Molecule Drug

Summary
Symbol	HDAC8
Name	histone deacetylase 8
Aliases	HDACL1; MRXS6; histone deacetylase-like 1; Wilson-Turner X-linked mental retardation syndrome; CDA07; CDLS5; ......
Location	Xq13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
20636436	Acute Lymphoid Leukemia	partner	ERRalpha	Deacetylation	HDAC8 and Sirt1 were also demonstrated to interact directly with ERRalpha in vivo and to deacetylate and increase the DNA binding affinity of ERRalpha in vitro.
25836739	Melanoma	partner	p65	Correlation	There was also a correlation between HDAC1, HDAC8 expression, and phosphorylated NFκb p65 immunoreactivity (P<0.001).