CR2Cancer

Summary
Symbol	HDGF
Name	heparin binding growth factor
Aliases	HMG1L2; high-mobility group protein 1-like; hepatoma-derived growth factor (high-mobility group protein 1-li ......
Location	1q23.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

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Domain

PF00855 PWWP domain

Function

Heparin-binding protein, with mitogenic activity for fibroblasts. Acts as a transcriptional repressor.

Classification

Class	Modification	Substrate	Product	PubMed
Chromatin remodelling	#	DNA motif	#	18331345, 17974029

> Gene Ontology [ TOP ]
Biological Process	GO:0006986 response to unfolded protein GO:0030968 endoplasmic reticulum unfolded protein response GO:0034620 cellular response to unfolded protein GO:0034976 response to endoplasmic reticulum stress GO:0035966 response to topologically incorrect protein GO:0035967 cellular response to topologically incorrect protein GO:0036498 IRE1-mediated unfolded protein response
Molecular Function	GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding GO:0001104 RNA polymerase II transcription cofactor activity GO:0001106 RNA polymerase II transcription corepressor activity GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding GO:0001221 transcription cofactor binding GO:0001222 transcription corepressor binding GO:0003714 transcription corepressor activity GO:0005539 glycosaminoglycan binding GO:0008083 growth factor activity GO:0008134 transcription factor binding GO:0008201 heparin binding GO:1901681 sulfur compound binding
Cellular Component	GO:0017053 transcriptional repressor complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-381070: IRE1alpha activates chaperones R-HSA-392499: Metabolism of proteins R-HSA-381119: Unfolded Protein Response (UPR) R-HSA-381038: XBP1(S) activates chaperone genes

Summary
Symbol	HDGF
Name	heparin binding growth factor
Aliases	HMG1L2; high-mobility group protein 1-like; hepatoma-derived growth factor (high-mobility group protein 1-li ......
Location	1q23.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM897355	c.199G>A	p.E67K	Substitution - Missense	Endometrium
COSM1334934	c.386C>T	p.A129V	Substitution - Missense	Large_intestine
COSM3475379	c.308C>T	p.S103F	Substitution - Missense	Skin
COSM1235643	c.403G>A	p.E135K	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1334940	c.149delT	p.F50fs*105	Deletion - Frameshift	Large_intestine
COSM897352	c.654_656delGGA	p.E218delE	Deletion - In frame	Endometrium
COSM3734911	c.295G>A	p.G99S	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1209427	c.455G>T	p.G152V	Substitution - Missense	Large_intestine
COSM1334938	c.149_150insT	p.G51fs*63	Insertion - Frameshift	Large_intestine
COSM3934148	c.52G>A	p.A18T	Substitution - Missense	Oesophagus
COSM3399818	c.486G>A	p.L162L	Substitution - coding silent	Central_nervous_system
COSM3385269	c.553T>C	p.L185L	Substitution - coding silent	Pancreas
COSM1209425	c.400G>A	p.D134N	Substitution - Missense	Large_intestine
COSM1639546	c.236G>C	p.R79T	Substitution - Missense	Stomach
COSM5499717	c.632C>T	p.P211L	Substitution - Missense	Biliary_tract
COSM1984242	c.294C>T	p.S98S	Substitution - coding silent	Bone
COSM1639544	c.303+6C>A	p.?	Unknown	Stomach
COSM5968876	c.418G>A	p.V140I	Substitution - Missense	Upper_aerodigestive_tract
COSM3475381	c.308C>A	p.S103Y	Substitution - Missense	Skin
COSM1209425	c.400G>A	p.D134N	Substitution - Missense	Liver
COSM1334940	c.149delT	p.F50fs*105	Deletion - Frameshift	Large_intestine
COSM1317655	c.564G>A	p.E188E	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM3750437	c.602C>T	p.P201L	Substitution - Missense	Large_intestine
COSM1334940	c.149delT	p.F50fs*105	Deletion - Frameshift	Large_intestine
COSM3984331	c.613G>A	p.G205S	Substitution - Missense	Kidney
COSM1637969	c.164+1G>T	p.?	Unknown	Bone
COSM4023392	c.341C>A	p.P114Q	Substitution - Missense	Stomach
COSM1600979	c.649G>A	p.E217K	Substitution - Missense	Liver
COSM23343	c.196T>G	p.Y66D	Substitution - Missense	Lung
COSM4488809	c.290C>T	p.A97V	Substitution - Missense	Skin
COSM3934146	c.267C>G	p.I89M	Substitution - Missense	Oesophagus
COSM1334940	c.149delT	p.F50fs*105	Deletion - Frameshift	Stomach
COSM3802249	c.87+2T>G	p.?	Unknown	Breast
COSM4576385	c.541G>C	p.E181Q	Substitution - Missense	Bone
COSM5788972	c.617C>G	p.S206C	Substitution - Missense	Breast
COSM384187	c.241G>A	p.G81R	Substitution - Missense	Lung
COSM1600979	c.649G>A	p.E217K	Substitution - Missense	Liver
COSM1334938	c.149_150insT	p.G51fs*63	Insertion - Frameshift	Large_intestine
COSM3710341	c.364G>A	p.D122N	Substitution - Missense	Upper_aerodigestive_tract
COSM4222876	c.174G>A	p.L58L	Substitution - coding silent	Oesophagus
COSM1293221	c.427G>T	p.E143*	Substitution - Nonsense	Cervix
COSM1334940	c.149delT	p.F50fs*105	Deletion - Frameshift	Large_intestine
COSM3475383	c.178C>T	p.P60S	Substitution - Missense	Skin
COSM4023395	c.198C>T	p.Y66Y	Substitution - coding silent	Stomach
COSM3802245	c.465G>A	p.K155K	Substitution - coding silent	Breast
COSM3746146	c.363T>C	p.G121G	Substitution - coding silent	Liver
COSM897354	c.458C>T	p.A153V	Substitution - Missense	Endometrium
COSM4576382	c.612C>T	p.P204P	Substitution - coding silent	Bone
COSM463167	c.453A>G	p.K151K	Substitution - coding silent	Kidney
COSM5788972	c.617C>G	p.S206C	Substitution - Missense	Breast
COSM676380	c.385G>T	p.A129S	Substitution - Missense	Lung
COSM3710341	c.364G>A	p.D122N	Substitution - Missense	Upper_aerodigestive_tract
COSM1600981	c.88-1_92delGATTGA	p.?	Unknown	Liver
COSM1209425	c.400G>A	p.D134N	Substitution - Missense	Liver
COSM1984230	c.402C>T	p.D134D	Substitution - coding silent	Large_intestine
COSM1668063	c.198C>A	p.Y66*	Substitution - Nonsense	Lung
COSM897353	c.459G>A	p.A153A	Substitution - coding silent	Endometrium
COSM4615862	c.165-1_165insAC	p.A56fs*100	Unknown	Large_intestine
COSM676381	c.526G>A	p.E176K	Substitution - Missense	Lung
COSM1209429	c.505C>T	p.P169S	Substitution - Missense	Large_intestine
COSM4548914	c.45G>C	p.L15L	Substitution - coding silent	Skin
COSM1334938	c.149_150insT	p.G51fs*63	Insertion - Frameshift	Large_intestine
COSM4576388	c.529G>A	p.G177R	Substitution - Missense	Bone
COSM1334940	c.149delT	p.F50fs*105	Deletion - Frameshift	Large_intestine
COSM4023395	c.198C>T	p.Y66Y	Substitution - coding silent	Large_intestine

> Text Mining based Variations [ TOP ]
There is no record for HDGF.

Summary
Symbol	HDGF
Name	heparin binding growth factor
Aliases	HMG1L2; high-mobility group protein 1-like; hepatoma-derived growth factor (high-mobility group protein 1-li ......
Location	1q23.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

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Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
P51858	132	S	Phosphoserine	-	No	None detected
P51858	133	S	Phosphoserine	-	No	None detected
P51858	165	S	Phosphoserine	-	No	None detected
P51858	184	T	Phosphothreonine	-	No	None detected
P51858	199	S	Phosphoserine	-	No	None detected
P51858	200	T	Phosphothreonine	-	No	None detected
P51858	202	S	Phosphoserine	-	No	None detected
P51858	206	S	Phosphoserine	-	No	None detected
P51858	239	S	Phosphoserine	-	No	None detected

Summary
Symbol	HDGF
Name	heparin binding growth factor
Aliases	HMG1L2; high-mobility group protein 1-like; hepatoma-derived growth factor (high-mobility group protein 1-li ......
Location	1q23.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

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Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	7.91	8.753	0.881	1.73e-09	Over
BRCA	Breast invasive carcinoma	112	1100	7.605	8.7	1.169	4.69e-73	Over
CESC	Cervical and endocervical cancers	3	306	7.563	9.106	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	8.308	8.805	0.502	1.35e-10	NS
ESCA	Esophageal carcinoma	11	185	7.253	8.728	1.275	6.45e-11	Over
GBM	Glioblastoma multiforme	5	166	7	7.977	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	8.256	8.752	0.536	6.92e-13	NS
KIRC	Kidney renal clear cell carcinoma	72	534	8.056	8.143	0.105	0.0785	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	8.01	8.137	0.151	0.131	NS
LAML	Acute Myeloid Leukemia	0	173	NA	8.14	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	7.798	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	8.317	8.472	0.139	0.0878	NS
LUAD	Lung adenocarcinoma	59	517	7.677	8.681	0.967	1.3e-28	Over
LUSC	Lung squamous cell carcinoma	51	501	7.587	8.892	1.246	7.5e-49	Over
OV	Ovarian serous cystadenocarcinoma	0	307	NA	9.506	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	7.901	8.329	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	7.479	6.944	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	7.378	7.712	0.366	9.49e-12	NS
READ	Rectum adenocarcinoma	10	167	8.008	8.861	0.811	8.65e-06	Over
SARC	Sarcoma	2	263	7.946	7.98	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	8.331	8.094	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	8.226	8.722	0.584	2.58e-06	Over
TGCT	Testicular Germ Cell Tumors	0	156	NA	7.604	NA	NA	NA
THCA	Thyroid carcinoma	59	509	7.869	7.959	0.1	0.0223	NS
THYM	Thymoma	2	120	8.097	8.847	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	7.589	8.786	1.135	6.19e-22	Over

> Cancer Cell Line Encyclopedia (CCLE)

[ TOP ]

Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	11.7
Autonomic ganglia	CHP212	11.2
Autonomic ganglia	IMR32	11.2
Autonomic ganglia	KELLY	11
Autonomic ganglia	KPNRTBM1	10.9
Autonomic ganglia	KPNSI9S	11.5
Autonomic ganglia	KPNYN	11
Autonomic ganglia	MHHNB11	11.7
Autonomic ganglia	NB1	12.3
Autonomic ganglia	NH6	10.9
Autonomic ganglia	SHSY5Y	11
Autonomic ganglia	SIMA	11.3
Autonomic ganglia	SKNAS	11.6
Autonomic ganglia	SKNBE2	11.4
Autonomic ganglia	SKNDZ	11.4
Autonomic ganglia	SKNFI	10.9
Autonomic ganglia	SKNSH	10.6
Biliary tract	HUCCT1	11.1
Biliary tract	HUH28	11.3
Biliary tract	SNU1079	11.8
Biliary tract	SNU1196	11.7
Biliary tract	SNU245	11.9
Biliary tract	SNU308	11.2
Biliary tract	SNU478	12.1
Bone	143B	10.9
Bone	A673	11.2
Bone	CADOES1	10.4
Bone	CAL78	10.9
Bone	G292CLONEA141B1	11.5
Bone	HOS	10.9
Bone	HS706T	10.5
Bone	HS737T	10.3
Bone	HS819T	10.1
Bone	HS821T	10.4
Bone	HS822T	10
Bone	HS863T	10.5
Bone	HS870T	10.6
Bone	HS888T	10.9
Bone	MG63	11.5
Bone	MHHES1	11.3
Bone	OUMS27	10.7
Bone	RDES	11.3
Bone	SJSA1	10.8
Bone	SKES1	11.4
Bone	SKNMC	11.2
Bone	SW1353	10.5
Bone	T173	10.1
Bone	TC71	10.9
Bone	U2OS	11.4
Breast	AU565	11.8
Breast	BT20	12.3
Breast	BT474	10.9
Breast	BT483	11.8
Breast	BT549	11.6
Breast	CAL120	11
Breast	CAL148	11.8
Breast	CAL51	11.2
Breast	CAL851	11.9
Breast	CAMA1	11.2
Breast	DU4475	11.1
Breast	EFM192A	11.5
Breast	EFM19	11.8
Breast	EVSAT	11.3
Breast	HCC1143	11.3
Breast	HCC1187	11.5
Breast	HCC1395	11.2
Breast	HCC1419	11.7
Breast	HCC1428	12.1
Breast	HCC1500	11.3
Breast	HCC1569	12.4
Breast	HCC1599	12.4
Breast	HCC1806	11.6
Breast	HCC1937	12
Breast	HCC1954	11.6
Breast	HCC202	11.6
Breast	HCC2157	11.3
Breast	HCC2218	11.3
Breast	HCC38	10.7
Breast	HCC70	12
Breast	HDQP1	11.4
Breast	HMC18	11.7
Breast	HS274T	10.4
Breast	HS281T	10.6
Breast	HS343T	10.8
Breast	HS578T	11
Breast	HS606T	10.3
Breast	HS739T	10.1
Breast	HS742T	9.6
Breast	JIMT1	10.9
Breast	KPL1	11.7
Breast	MCF7	10.9
Breast	MDAMB134VI	11.3
Breast	MDAMB157	10.4
Breast	MDAMB175VII	11.3
Breast	MDAMB231	11.1
Breast	MDAMB361	11.4
Breast	MDAMB415	11.2
Breast	MDAMB436	11.2
Breast	MDAMB453	11.6
Breast	MDAMB468	11.6
Breast	SKBR3	11.6
Breast	T47D	11.1
Breast	UACC812	10.5
Breast	UACC893	11.9
Breast	YMB1	11.2
Breast	ZR751	11.4
Breast	ZR7530	12
Central nervous system	1321N1	11.3
Central nervous system	42MGBA	10.5
Central nervous system	8MGBA	10.5
Central nervous system	A172	10.9
Central nervous system	AM38	10.8
Central nervous system	BECKER	10.8
Central nervous system	CAS1	10.5
Central nervous system	CCFSTTG1	10.6
Central nervous system	D283MED	11.7
Central nervous system	D341MED	11.1
Central nervous system	DAOY	11.4
Central nervous system	DBTRG05MG	9.8
Central nervous system	DKMG	9.5
Central nervous system	GAMG	9.9
Central nervous system	GB1	11.1
Central nervous system	GI1	11.4
Central nervous system	GMS10	10.5
Central nervous system	GOS3	10.9
Central nervous system	H4	10.9
Central nervous system	HS683	10.9
Central nervous system	KALS1	10.6
Central nervous system	KG1C	10.1
Central nervous system	KNS42	11.4
Central nervous system	KNS60	11
Central nervous system	KNS81	10.4
Central nervous system	KS1	10.6
Central nervous system	LN18	10.4
Central nervous system	LN229	10.9
Central nervous system	M059K	11.1
Central nervous system	MOGGCCM	11
Central nervous system	MOGGUVW	11.2
Central nervous system	NMCG1	10.2
Central nervous system	ONS76	11.1
Central nervous system	SF126	10.7
Central nervous system	SF295	10.7
Central nervous system	SNB19	10.8
Central nervous system	SNU1105	10.9
Central nervous system	SNU201	10.5
Central nervous system	SNU466	10.5
Central nervous system	SNU489	10.6
Central nervous system	SNU626	11
Central nervous system	SNU738	11.3
Central nervous system	SW1088	10.5
Central nervous system	SW1783	10.2
Central nervous system	T98G	11.1
Central nervous system	TM31	11.1
Central nervous system	U118MG	10.8
Central nervous system	U138MG	11.1
Central nervous system	U251MG	10.2
Central nervous system	U87MG	11.1
Central nervous system	YH13	10.9
Central nervous system	YKG1	10.5
Endometrium	AN3CA	10.3
Endometrium	COLO684	12.5
Endometrium	EFE184	12
Endometrium	EN	11.3
Endometrium	ESS1	11
Endometrium	HEC108	10.6
Endometrium	HEC151	10.9
Endometrium	HEC1A	10.9
Endometrium	HEC1B	11.6
Endometrium	HEC251	11.2
Endometrium	HEC265	11.1
Endometrium	HEC50B	10.8
Endometrium	HEC59	11.1
Endometrium	HEC6	10.2
Endometrium	ISHIKAWAHERAKLIO02ER	10.7
Endometrium	JHUEM1	10.9
Endometrium	JHUEM2	11.3
Endometrium	JHUEM3	11.1
Endometrium	KLE	11.3
Endometrium	MFE280	11.1
Endometrium	MFE296	10.8
Endometrium	MFE319	11.3
Endometrium	RL952	11.4
Endometrium	SNGM	11
Endometrium	SNU1077	11.3
Endometrium	SNU685	11.7
Endometrium	TEN	11.8
Haematopoietic and lymphoid	697	11.7
Haematopoietic and lymphoid	A3KAW	11.5
Haematopoietic and lymphoid	A4FUK	10.8
Haematopoietic and lymphoid	ALLSIL	11
Haematopoietic and lymphoid	AML193	11.3
Haematopoietic and lymphoid	AMO1	11.9
Haematopoietic and lymphoid	BCP1	11.1
Haematopoietic and lymphoid	BDCM	10.9
Haematopoietic and lymphoid	BL41	11.5
Haematopoietic and lymphoid	BL70	11.6
Haematopoietic and lymphoid	BV173	12.2
Haematopoietic and lymphoid	CA46	10.7
Haematopoietic and lymphoid	CI1	10.9
Haematopoietic and lymphoid	CMK115	10.7
Haematopoietic and lymphoid	CMK86	11.3
Haematopoietic and lymphoid	CMK	10.9
Haematopoietic and lymphoid	CMLT1	10.7
Haematopoietic and lymphoid	COLO775	11.9
Haematopoietic and lymphoid	DAUDI	10.7
Haematopoietic and lymphoid	DB	11
Haematopoietic and lymphoid	DEL	10.9
Haematopoietic and lymphoid	DND41	11.4
Haematopoietic and lymphoid	DOHH2	10.9
Haematopoietic and lymphoid	EB1	10.4
Haematopoietic and lymphoid	EB2	10.6
Haematopoietic and lymphoid	EHEB	10.8
Haematopoietic and lymphoid	EJM	11.2
Haematopoietic and lymphoid	EM2	11.2
Haematopoietic and lymphoid	EOL1	10.9
Haematopoietic and lymphoid	F36P	11
Haematopoietic and lymphoid	GA10	11.8
Haematopoietic and lymphoid	GDM1	11
Haematopoietic and lymphoid	GRANTA519	11.2
Haematopoietic and lymphoid	HDLM2	10.9
Haematopoietic and lymphoid	HDMYZ	11.3
Haematopoietic and lymphoid	HEL9217	11.1
Haematopoietic and lymphoid	HEL	11.1
Haematopoietic and lymphoid	HH	11.4
Haematopoietic and lymphoid	HL60	12
Haematopoietic and lymphoid	HPBALL	11.6
Haematopoietic and lymphoid	HS604T	11.1
Haematopoietic and lymphoid	HS611T	10.1
Haematopoietic and lymphoid	HS616T	10.6
Haematopoietic and lymphoid	HS751T	10
Haematopoietic and lymphoid	HT	10.6
Haematopoietic and lymphoid	HTK	11.6
Haematopoietic and lymphoid	HUNS1	10.7
Haematopoietic and lymphoid	HUT102	10.2
Haematopoietic and lymphoid	HUT78	10.4
Haematopoietic and lymphoid	JEKO1	11.8
Haematopoietic and lymphoid	JK1	11.7
Haematopoietic and lymphoid	JM1	11.6
Haematopoietic and lymphoid	JURKAT	10.7
Haematopoietic and lymphoid	JURLMK1	10.8
Haematopoietic and lymphoid	JVM2	10.5
Haematopoietic and lymphoid	JVM3	10.4
Haematopoietic and lymphoid	K562	10.7
Haematopoietic and lymphoid	KARPAS299	11.7
Haematopoietic and lymphoid	KARPAS422	10.8
Haematopoietic and lymphoid	KARPAS620	11
Haematopoietic and lymphoid	KASUMI1	10.8
Haematopoietic and lymphoid	KASUMI2	11.7
Haematopoietic and lymphoid	KASUMI6	11.6
Haematopoietic and lymphoid	KCL22	11.8
Haematopoietic and lymphoid	KE37	11.1
Haematopoietic and lymphoid	KE97	10.5
Haematopoietic and lymphoid	KG1	10.9
Haematopoietic and lymphoid	KHM1B	11.9
Haematopoietic and lymphoid	KIJK	11.5
Haematopoietic and lymphoid	KMH2	11.1
Haematopoietic and lymphoid	KMM1	11.4
Haematopoietic and lymphoid	KMS11	12.3
Haematopoietic and lymphoid	KMS12BM	11.6
Haematopoietic and lymphoid	KMS18	10.9
Haematopoietic and lymphoid	KMS20	11.8
Haematopoietic and lymphoid	KMS21BM	11.1
Haematopoietic and lymphoid	KMS26	11.3
Haematopoietic and lymphoid	KMS27	11.3
Haematopoietic and lymphoid	KMS28BM	11.5
Haematopoietic and lymphoid	KMS34	11.4
Haematopoietic and lymphoid	KO52	10.9
Haematopoietic and lymphoid	KOPN8	11.4
Haematopoietic and lymphoid	KU812	11.4
Haematopoietic and lymphoid	KYO1	11.4
Haematopoietic and lymphoid	L1236	10.9
Haematopoietic and lymphoid	L363	10.9
Haematopoietic and lymphoid	L428	10.8
Haematopoietic and lymphoid	L540	10.8
Haematopoietic and lymphoid	LAMA84	10.6
Haematopoietic and lymphoid	LOUCY	10.7
Haematopoietic and lymphoid	LP1	11
Haematopoietic and lymphoid	M07E	11
Haematopoietic and lymphoid	MC116	11.3
Haematopoietic and lymphoid	ME1	11.4
Haematopoietic and lymphoid	MEC1	10.1
Haematopoietic and lymphoid	MEC2	10.9
Haematopoietic and lymphoid	MEG01	11
Haematopoietic and lymphoid	MHHCALL2	11.2
Haematopoietic and lymphoid	MHHCALL3	12
Haematopoietic and lymphoid	MHHCALL4	11.2
Haematopoietic and lymphoid	MINO	11.2
Haematopoietic and lymphoid	MJ	11.1
Haematopoietic and lymphoid	MM1S	11.5
Haematopoietic and lymphoid	MOLM13	11.2
Haematopoietic and lymphoid	MOLM16	11.3
Haematopoietic and lymphoid	MOLM6	11.7
Haematopoietic and lymphoid	MOLP2	11.2
Haematopoietic and lymphoid	MOLP8	11.6
Haematopoietic and lymphoid	MOLT13	10.8
Haematopoietic and lymphoid	MOLT16	10.8
Haematopoietic and lymphoid	MOLT4	10.6
Haematopoietic and lymphoid	MONOMAC1	10.9
Haematopoietic and lymphoid	MONOMAC6	11
Haematopoietic and lymphoid	MOTN1	11.2
Haematopoietic and lymphoid	MUTZ5	11.2
Haematopoietic and lymphoid	MV411	11.4
Haematopoietic and lymphoid	NALM19	11.4
Haematopoietic and lymphoid	NALM1	11.5
Haematopoietic and lymphoid	NALM6	12
Haematopoietic and lymphoid	NAMALWA	11.9
Haematopoietic and lymphoid	NB4	11.3
Haematopoietic and lymphoid	NCIH929	11.2
Haematopoietic and lymphoid	NCO2	10.4
Haematopoietic and lymphoid	NOMO1	11.1
Haematopoietic and lymphoid	NUDHL1	11.6
Haematopoietic and lymphoid	NUDUL1	11.9
Haematopoietic and lymphoid	OCIAML2	10.8
Haematopoietic and lymphoid	OCIAML3	11.5
Haematopoietic and lymphoid	OCIAML5	11.4
Haematopoietic and lymphoid	OCILY10	10.9
Haematopoietic and lymphoid	OCILY19	11.7
Haematopoietic and lymphoid	OCILY3	11.1
Haematopoietic and lymphoid	OCIM1	10.6
Haematopoietic and lymphoid	OPM2	11.8
Haematopoietic and lymphoid	P12ICHIKAWA	11.2
Haematopoietic and lymphoid	P31FUJ	11.1
Haematopoietic and lymphoid	P3HR1	11
Haematopoietic and lymphoid	PCM6	10.4
Haematopoietic and lymphoid	PEER	10.5
Haematopoietic and lymphoid	PF382	10.8
Haematopoietic and lymphoid	PFEIFFER	10.8
Haematopoietic and lymphoid	PL21	11.5
Haematopoietic and lymphoid	RAJI	11.1
Haematopoietic and lymphoid	RCHACV	12
Haematopoietic and lymphoid	REC1	10.4
Haematopoietic and lymphoid	REH	11.2
Haematopoietic and lymphoid	RI1	11.5
Haematopoietic and lymphoid	RL	11.2
Haematopoietic and lymphoid	RPMI8226	11.5
Haematopoietic and lymphoid	RPMI8402	10.9
Haematopoietic and lymphoid	RS411	11.2
Haematopoietic and lymphoid	SEM	11.1
Haematopoietic and lymphoid	SET2	11.3
Haematopoietic and lymphoid	SIGM5	11.5
Haematopoietic and lymphoid	SKM1	11.2
Haematopoietic and lymphoid	SKMM2	11.4
Haematopoietic and lymphoid	SR786	11
Haematopoietic and lymphoid	ST486	11
Haematopoietic and lymphoid	SUDHL10	11.6
Haematopoietic and lymphoid	SUDHL1	11
Haematopoietic and lymphoid	SUDHL4	11.6
Haematopoietic and lymphoid	SUDHL5	11
Haematopoietic and lymphoid	SUDHL6	11.2
Haematopoietic and lymphoid	SUDHL8	11.4
Haematopoietic and lymphoid	SUPB15	11.2
Haematopoietic and lymphoid	SUPHD1	11.9
Haematopoietic and lymphoid	SUPM2	10.3
Haematopoietic and lymphoid	SUPT11	11.1
Haematopoietic and lymphoid	SUPT1	10.7
Haematopoietic and lymphoid	TALL1	10.7
Haematopoietic and lymphoid	TF1	11.3
Haematopoietic and lymphoid	THP1	11.1
Haematopoietic and lymphoid	TO175T	10.8
Haematopoietic and lymphoid	TOLEDO	11.5
Haematopoietic and lymphoid	U266B1	11.5
Haematopoietic and lymphoid	U937	11.3
Haematopoietic and lymphoid	UT7	11.2
Haematopoietic and lymphoid	WSUDLCL2	10.9
Kidney	769P	11.4
Kidney	786O	11.7
Kidney	A498	11.6
Kidney	A704	10.3
Kidney	ACHN	11.4
Kidney	BFTC909	11
Kidney	CAKI1	11.8
Kidney	CAKI2	11.5
Kidney	CAL54	11.1
Kidney	KMRC1	11.4
Kidney	KMRC20	11.6
Kidney	KMRC2	11.3
Kidney	KMRC3	10.4
Kidney	OSRC2	11.3
Kidney	RCC10RGB	10.7
Kidney	SNU1272	11.7
Kidney	SNU349	11.2
Kidney	TUHR10TKB	11.7
Kidney	TUHR14TKB	10.9
Kidney	TUHR4TKB	11.3
Kidney	VMRCRCW	11
Kidney	VMRCRCZ	11.2
Large intestine	C2BBE1	11.2
Large intestine	CCK81	11.8
Large intestine	CL11	11.3
Large intestine	CL14	12
Large intestine	CL34	11.3
Large intestine	CL40	11.5
Large intestine	COLO205	11
Large intestine	COLO320	11.7
Large intestine	COLO678	11.8
Large intestine	CW2	11
Large intestine	DLD1	11.1
Large intestine	GP2D	11
Large intestine	HCC56	11.4
Large intestine	HCT116	10.9
Large intestine	HCT15	10.9
Large intestine	HS675T	10.5
Large intestine	HS698T	10.7
Large intestine	HT115	11.6
Large intestine	HT29	11.8
Large intestine	HT55	11.5
Large intestine	KM12	11.2
Large intestine	LOVO	11.2
Large intestine	LS1034	11.2
Large intestine	LS123	11.6
Large intestine	LS180	11.3
Large intestine	LS411N	11
Large intestine	LS513	11.3
Large intestine	MDST8	11.1
Large intestine	NCIH508	11.3
Large intestine	NCIH716	11.1
Large intestine	NCIH747	11.7
Large intestine	OUMS23	11
Large intestine	RCM1	11.2
Large intestine	RKO	10.7
Large intestine	SKCO1	11.5
Large intestine	SNU1040	11.5
Large intestine	SNU1197	11.3
Large intestine	SNU175	10.7
Large intestine	SNU283	12.1
Large intestine	SNU407	12.1
Large intestine	SNU503	11.4
Large intestine	SNU61	11.9
Large intestine	SNU81	11.7
Large intestine	SNUC1	11.8
Large intestine	SNUC2A	10.6
Large intestine	SNUC4	11.1
Large intestine	SNUC5	11.4
Large intestine	SW1116	11.1
Large intestine	SW1417	11.4
Large intestine	SW1463	11.5
Large intestine	SW403	11.5
Large intestine	SW480	10.6
Large intestine	SW48	10.6
Large intestine	SW620	11.1
Large intestine	SW837	10.6
Large intestine	SW948	11.3
Large intestine	T84	12
Liver	ALEXANDERCELLS	11.3
Liver	C3A	10.9
Liver	HEP3B217	11.6
Liver	HEPG2	10.8
Liver	HLE	10.5
Liver	HLF	11.1
Liver	HUH1	11.7
Liver	HUH6	11.7
Liver	HUH7	11.1
Liver	JHH1	11.3
Liver	JHH2	11.5
Liver	JHH4	11.5
Liver	JHH5	11.6
Liver	JHH6	10.9
Liver	JHH7	11.1
Liver	LI7	11.6
Liver	PLCPRF5	11.3
Liver	SKHEP1	10.6
Liver	SNU182	10.9
Liver	SNU387	11.5
Liver	SNU398	11.2
Liver	SNU423	10.9
Liver	SNU449	11.3
Liver	SNU475	11.4
Liver	SNU761	11.3
Liver	SNU878	11.6
Liver	SNU886	11.8
Lung	A549	11.2
Lung	ABC1	11.6
Lung	BEN	11.3
Lung	CAL12T	11
Lung	CALU1	11.7
Lung	CALU3	11.5
Lung	CALU6	11.5
Lung	CHAGOK1	11.5
Lung	COLO668	11.5
Lung	COLO699	10.7
Lung	CORL105	11.3
Lung	CORL23	11.6
Lung	CORL24	10.4
Lung	CORL279	11.4
Lung	CORL311	11
Lung	CORL47	10.9
Lung	CORL51	10.8
Lung	CORL88	11
Lung	CORL95	11.2
Lung	CPCN	10.6
Lung	DMS114	10.8
Lung	DMS153	11.5
Lung	DMS273	11.2
Lung	DMS454	10.9
Lung	DMS53	10.8
Lung	DMS79	10.9
Lung	DV90	11.1
Lung	EBC1	10.4
Lung	EPLC272H	11.3
Lung	HARA	11.2
Lung	HCC1171	12.1
Lung	HCC1195	12.1
Lung	HCC15	11.2
Lung	HCC2279	11
Lung	HCC2935	11.2
Lung	HCC33	11.3
Lung	HCC366	10.6
Lung	HCC4006	11.3
Lung	HCC44	11.3
Lung	HCC78	12
Lung	HCC827	11.6
Lung	HCC95	10.6
Lung	HLC1	11.2
Lung	HLFA	10.4
Lung	HS229T	10.4
Lung	HS618T	10.3
Lung	IALM	11.2
Lung	KNS62	11.8
Lung	LC1F	11.6
Lung	LC1SQSF	11.4
Lung	LCLC103H	10.8
Lung	LCLC97TM1	11.9
Lung	LK2	11.4
Lung	LOUNH91	11
Lung	LU65	11.1
Lung	LU99	11
Lung	LUDLU1	11.8
Lung	LXF289	11.5
Lung	MORCPR	12.4
Lung	NCIH1048	11.1
Lung	NCIH1092	10.5
Lung	NCIH1105	10.6
Lung	NCIH1155	10.4
Lung	NCIH1184	10.9
Lung	NCIH1299	11.8
Lung	NCIH1339	10.7
Lung	NCIH1341	11.1
Lung	NCIH1355	11.4
Lung	NCIH1373	11.3
Lung	NCIH1385	11.6
Lung	NCIH1395	10.1
Lung	NCIH1435	11.7
Lung	NCIH1436	10.9
Lung	NCIH1437	11.7
Lung	NCIH146	11.3
Lung	NCIH1563	11
Lung	NCIH1568	10.9
Lung	NCIH1573	10.9
Lung	NCIH1581	11.2
Lung	NCIH1618	11.5
Lung	NCIH1623	11.8
Lung	NCIH1648	10.9
Lung	NCIH1650	11.6
Lung	NCIH1651	10.9
Lung	NCIH1666	11.5
Lung	NCIH1693	10.6
Lung	NCIH1694	11.3
Lung	NCIH1703	10.6
Lung	NCIH1734	11
Lung	NCIH1755	11.2
Lung	NCIH1781	11.8
Lung	NCIH1792	11.7
Lung	NCIH1793	11.2
Lung	NCIH1836	10.9
Lung	NCIH1838	11.3
Lung	NCIH1869	11.8
Lung	NCIH1876	11.7
Lung	NCIH1915	10.6
Lung	NCIH1930	10.7
Lung	NCIH1944	12
Lung	NCIH1963	11.4
Lung	NCIH196	11.2
Lung	NCIH1975	11.5
Lung	NCIH2009	11.8
Lung	NCIH2023	11.1
Lung	NCIH2029	10.6
Lung	NCIH2030	11.7
Lung	NCIH2066	10.7
Lung	NCIH2081	11.1
Lung	NCIH2085	10.9
Lung	NCIH2087	11.4
Lung	NCIH209	11.3
Lung	NCIH2106	11.5
Lung	NCIH2110	12.2
Lung	NCIH211	10.3
Lung	NCIH2122	11.6
Lung	NCIH2126	10.6
Lung	NCIH2141	11.6
Lung	NCIH2170	12.1
Lung	NCIH2171	11.5
Lung	NCIH2172	11.7
Lung	NCIH2196	11.2
Lung	NCIH2227	10.7
Lung	NCIH2228	11.8
Lung	NCIH226	10.9
Lung	NCIH2286	10.7
Lung	NCIH2291	11.3
Lung	NCIH2342	10.9
Lung	NCIH2347	11.3
Lung	NCIH23	12
Lung	NCIH2405	11
Lung	NCIH2444	12.1
Lung	NCIH292	11.5
Lung	NCIH322	11.4
Lung	NCIH3255	11.4
Lung	NCIH358	12
Lung	NCIH441	11.5
Lung	NCIH446	11.3
Lung	NCIH460	11.5
Lung	NCIH510	10.8
Lung	NCIH520	11.3
Lung	NCIH522	10.5
Lung	NCIH524	10.5
Lung	NCIH526	12.2
Lung	NCIH596	11
Lung	NCIH647	11.8
Lung	NCIH650	10.9
Lung	NCIH661	10.2
Lung	NCIH69	10.8
Lung	NCIH727	11.2
Lung	NCIH810	12.3
Lung	NCIH82	11.5
Lung	NCIH838	11.4
Lung	NCIH841	11.4
Lung	NCIH854	11.6
Lung	NCIH889	10.7
Lung	PC14	11.5
Lung	RERFLCAD1	10.9
Lung	RERFLCAD2	10.7
Lung	RERFLCAI	11.7
Lung	RERFLCKJ	11.2
Lung	RERFLCMS	11.2
Lung	RERFLCSQ1	10.7
Lung	SBC5	11.1
Lung	SCLC21H	11.6
Lung	SHP77	11.5
Lung	SKLU1	11.1
Lung	SKMES1	11
Lung	SQ1	12.4
Lung	SW1271	11.1
Lung	SW1573	10.8
Lung	SW900	11.8
Lung	VMRCLCD	12.1
Lung	VMRCLCP	11.4
Oesophagus	COLO680N	10.8
Oesophagus	ECGI10	11.3
Oesophagus	KYSE140	11.4
Oesophagus	KYSE150	11.3
Oesophagus	KYSE180	11.7
Oesophagus	KYSE270	11.6
Oesophagus	KYSE30	11.2
Oesophagus	KYSE410	11.5
Oesophagus	KYSE450	11.1
Oesophagus	KYSE510	12.2
Oesophagus	KYSE520	11.5
Oesophagus	KYSE70	10.7
Oesophagus	OE19	12.2
Oesophagus	OE33	10.8
Oesophagus	TE10	11.4
Oesophagus	TE11	11.4
Oesophagus	TE14	11.6
Oesophagus	TE15	11.2
Oesophagus	TE1	11.2
Oesophagus	TE4	11.6
Oesophagus	TE5	10.7
Oesophagus	TE6	11
Oesophagus	TE8	10.5
Oesophagus	TE9	11.2
Oesophagus	TT	10.9
Ovary	59M	11.8
Ovary	A2780	11.2
Ovary	CAOV3	10.7
Ovary	CAOV4	11.4
Ovary	COLO704	11.9
Ovary	COV318	12
Ovary	COV362	11.4
Ovary	COV434	10.2
Ovary	COV504	11.3
Ovary	COV644	11.2
Ovary	EFO21	11.3
Ovary	EFO27	11
Ovary	ES2	11.1
Ovary	FUOV1	11.2
Ovary	HEYA8	11.3
Ovary	HS571T	10.4
Ovary	IGROV1	11.4
Ovary	JHOC5	11.2
Ovary	JHOM1	10.6
Ovary	JHOM2B	11.8
Ovary	JHOS2	11.4
Ovary	JHOS4	10.9
Ovary	KURAMOCHI	12.2
Ovary	MCAS	11.7
Ovary	NIHOVCAR3	11.1
Ovary	OAW28	11.2
Ovary	OAW42	11.5
Ovary	OC314	11
Ovary	OC316	11
Ovary	ONCODG1	11.3
Ovary	OV56	11.3
Ovary	OV7	11
Ovary	OV90	11.1
Ovary	OVCAR4	11.2
Ovary	OVCAR8	10.5
Ovary	OVISE	11
Ovary	OVK18	11.6
Ovary	OVKATE	11.9
Ovary	OVMANA	10.5
Ovary	OVSAHO	11.5
Ovary	OVTOKO	11.1
Ovary	RMGI	11.8
Ovary	RMUGS	11.8
Ovary	SKOV3	11.5
Ovary	SNU119	12.2
Ovary	SNU840	11.6
Ovary	SNU8	11.7
Ovary	TOV112D	11.4
Ovary	TOV21G	10.9
Ovary	TYKNU	11.2
Pancreas	ASPC1	11.4
Pancreas	BXPC3	11.4
Pancreas	CAPAN1	12
Pancreas	CAPAN2	11.5
Pancreas	CFPAC1	11.5
Pancreas	DANG	11.2
Pancreas	HPAC	11.5
Pancreas	HPAFII	11.6
Pancreas	HS766T	11
Pancreas	HUPT3	11.5
Pancreas	HUPT4	10.8
Pancreas	KCIMOH1	11.4
Pancreas	KLM1	12
Pancreas	KP2	11.1
Pancreas	KP3	10.9
Pancreas	KP4	10.4
Pancreas	L33	11.4
Pancreas	MIAPACA2	11.7
Pancreas	PANC0203	11.7
Pancreas	PANC0213	11
Pancreas	PANC0327	11.5
Pancreas	PANC0403	11.8
Pancreas	PANC0504	10.4
Pancreas	PANC0813	11.3
Pancreas	PANC1005	11.6
Pancreas	PANC1	10.7
Pancreas	PATU8902	11.4
Pancreas	PATU8988S	11.5
Pancreas	PATU8988T	11.8
Pancreas	PK1	11.1
Pancreas	PK45H	11.8
Pancreas	PK59	10.8
Pancreas	PL45	11.4
Pancreas	PSN1	11.6
Pancreas	QGP1	10.7
Pancreas	SNU213	11.1
Pancreas	SNU324	12.5
Pancreas	SNU410	11.2
Pancreas	SU8686	11.2
Pancreas	SUIT2	11
Pancreas	SW1990	11.1
Pancreas	T3M4	11.1
Pancreas	TCCPAN2	11.6
Pancreas	YAPC	10.6
Pleura	ACCMESO1	10.9
Pleura	DM3	10.4
Pleura	ISTMES1	10.6
Pleura	ISTMES2	11.2
Pleura	JL1	11.5
Pleura	MPP89	11.3
Pleura	MSTO211H	10.9
Pleura	NCIH2052	10.8
Pleura	NCIH2452	10.9
Pleura	NCIH28	11.6
Prostate	22RV1	11.4
Prostate	DU145	11.5
Prostate	LNCAPCLONEFGC	10.8
Prostate	MDAPCA2B	10.7
Prostate	NCIH660	10.4
Prostate	PC3	11.8
Prostate	VCAP	10.7
Salivary gland	A253	10.8
Salivary gland	YD15	11.3
Skin	A101D	11.1
Skin	A2058	11.7
Skin	A375	11.8
Skin	C32	11.1
Skin	CHL1	10.5
Skin	CJM	10.6
Skin	COLO679	11
Skin	COLO741	10.6
Skin	COLO783	9.8
Skin	COLO792	10.4
Skin	COLO800	11
Skin	COLO818	10.9
Skin	COLO829	10.5
Skin	COLO849	11.4
Skin	G361	11
Skin	GRM	12.3
Skin	HMCB	10.8
Skin	HS294T	11.2
Skin	HS600T	10.4
Skin	HS688AT	10.4
Skin	HS695T	11.1
Skin	HS839T	10.6
Skin	HS852T	11.5
Skin	HS895T	10.2
Skin	HS934T	10.7
Skin	HS936T	10.3
Skin	HS939T	10.3
Skin	HS940T	10.4
Skin	HS944T	11.3
Skin	HT144	10.8
Skin	IGR1	10
Skin	IGR37	11.2
Skin	IGR39	10.9
Skin	IPC298	10.4
Skin	K029AX	10.7
Skin	LOXIMVI	11.3
Skin	MALME3M	10.2
Skin	MDAMB435S	10.3
Skin	MELHO	10.7
Skin	MELJUSO	10.5
Skin	MEWO	10.5
Skin	RPMI7951	11.1
Skin	RVH421	10.1
Skin	SH4	10.6
Skin	SKMEL1	9.8
Skin	SKMEL24	10.3
Skin	SKMEL28	10.5
Skin	SKMEL2	10.2
Skin	SKMEL30	11
Skin	SKMEL31	9.6
Skin	SKMEL3	10.6
Skin	SKMEL5	10.8
Skin	UACC257	10.7
Skin	UACC62	10.9
Skin	WM115	10.3
Skin	WM1799	10.5
Skin	WM2664	10
Skin	WM793	11
Skin	WM88	10.8
Skin	WM983B	10.1
Small intestine	HUTU80	10.9
Soft tissue	A204	10.7
Soft tissue	G401	11.4
Soft tissue	G402	11.1
Soft tissue	GCT	11.2
Soft tissue	HS729	11.3
Soft tissue	HT1080	11
Soft tissue	KYM1	11
Soft tissue	MESSA	11.4
Soft tissue	RD	11.5
Soft tissue	RH30	11.4
Soft tissue	RH41	11.3
Soft tissue	RKN	11.1
Soft tissue	S117	11.4
Soft tissue	SJRH30	11.2
Soft tissue	SKLMS1	10.2
Soft tissue	SKUT1	10.7
Soft tissue	TE125T	10.4
Soft tissue	TE159T	10.4
Soft tissue	TE441T	10.6
Soft tissue	TE617T	10.8
Stomach	2313287	11.8
Stomach	AGS	11.3
Stomach	AZ521	11.1
Stomach	ECC10	11.2
Stomach	ECC12	12
Stomach	FU97	11.4
Stomach	GCIY	11.3
Stomach	GSS	11.1
Stomach	GSU	11.4
Stomach	HGC27	10.8
Stomach	HS746T	10.2
Stomach	HUG1N	11.6
Stomach	IM95	11.4
Stomach	KATOIII	11
Stomach	KE39	11.2
Stomach	LMSU	11.6
Stomach	MKN1	11
Stomach	MKN45	11.3
Stomach	MKN74	11
Stomach	MKN7	11.7
Stomach	NCCSTCK140	11
Stomach	NCIN87	11.7
Stomach	NUGC2	12
Stomach	NUGC3	12.1
Stomach	NUGC4	11
Stomach	OCUM1	11.5
Stomach	RERFGC1B	11.1
Stomach	SH10TC	10.9
Stomach	SNU16	11.6
Stomach	SNU1	10.9
Stomach	SNU216	11.3
Stomach	SNU520	11.4
Stomach	SNU5	11
Stomach	SNU601	11.8
Stomach	SNU620	11.1
Stomach	SNU668	11.6
Stomach	SNU719	11.3
Stomach	TGBC11TKB	11.2
Thyroid	8305C	10.9
Thyroid	8505C	10.7
Thyroid	BCPAP	10.5
Thyroid	BHT101	11.7
Thyroid	CAL62	10.9
Thyroid	CGTHW1	11.2
Thyroid	FTC133	10.6
Thyroid	FTC238	10.6
Thyroid	ML1	11
Thyroid	SW579	11.4
Thyroid	TT2609C02	11
Thyroid	TT	11.2
Upper aerodigestive tract	BHY	10.5
Upper aerodigestive tract	BICR16	11.4
Upper aerodigestive tract	BICR18	10.7
Upper aerodigestive tract	BICR22	11.4
Upper aerodigestive tract	BICR31	10.8
Upper aerodigestive tract	BICR56	11
Upper aerodigestive tract	BICR6	11.6
Upper aerodigestive tract	CAL27	11.4
Upper aerodigestive tract	CAL33	11.7
Upper aerodigestive tract	DETROIT562	11.4
Upper aerodigestive tract	FADU	11.6
Upper aerodigestive tract	HS840T	10.7
Upper aerodigestive tract	HSC2	11.1
Upper aerodigestive tract	HSC3	11
Upper aerodigestive tract	HSC4	11.1
Upper aerodigestive tract	PECAPJ15	11.1
Upper aerodigestive tract	PECAPJ34CLONEC12	11.3
Upper aerodigestive tract	PECAPJ41CLONED2	11.4
Upper aerodigestive tract	PECAPJ49	10.4
Upper aerodigestive tract	SCC15	11.5
Upper aerodigestive tract	SCC25	11.9
Upper aerodigestive tract	SCC4	10.9
Upper aerodigestive tract	SCC9	10.7
Upper aerodigestive tract	SNU1076	10.9
Upper aerodigestive tract	SNU1214	11.6
Upper aerodigestive tract	SNU46	11.5
Upper aerodigestive tract	SNU899	11.1
Upper aerodigestive tract	YD10B	11.7
Upper aerodigestive tract	YD38	12
Upper aerodigestive tract	YD8	10.7
Urinary tract	5637	11.3
Urinary tract	639V	10.9
Urinary tract	647V	12.3
Urinary tract	BC3C	11.3
Urinary tract	BFTC905	11.5
Urinary tract	CAL29	11.3
Urinary tract	HS172T	10.5
Urinary tract	HT1197	10.7
Urinary tract	HT1376	11.2
Urinary tract	J82	11.2
Urinary tract	JMSU1	12.4
Urinary tract	KMBC2	10.6
Urinary tract	KU1919	11.1
Urinary tract	RT11284	11.2
Urinary tract	RT112	11.7
Urinary tract	RT4	10.9
Urinary tract	SCABER	11.8
Urinary tract	SW1710	11.3
Urinary tract	SW780	11
Urinary tract	T24	11.2
Urinary tract	TCCSUP	11.7
Urinary tract	UMUC1	11.7
Urinary tract	UMUC3	10.5
Urinary tract	VMCUB1	11.2

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	81.4
Adrenal gland	80.6
Appendix	104.3
Bone marrow	190.7
Breast	106.5
Cerebral cortex	79.9
Cervix, uterine	108.7
Colon	110.1
Duodenum	140
Endometrium	114.8
Epididymis	85.1
Esophagus	94.8
Fallopian tube	178
Gallbladder	102.4
Heart muscle	48.6
Kidney	125
Liver	117.5
Lung	101.3
Lymph node	77.8
Ovary	70.9
Pancreas	12.3
Parathyroid gland	126.7
Placenta	103.2
Prostate	96.9
Rectum	134.3
Salivary gland	25.5
Seminal vesicle	81.5
Skeletal muscle	69.5
Skin	136.4
Small intestine	149.5
Smooth muscle	102
Spleen	70.6
Stomach	78.8
Testis	59.9
Thyroid gland	121.5
Tonsil	109.7
Urinary bladder	80.5

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
25071353	overexpression	Gallbladder Carcinoma	Nuclear HDGF expression was significantly higher (77.5%) in GBC than in chronic cholelithiasis (21.5%, P < 0.001).
25071353	overexpression	Glioma	HDGF is overexpressed in gliomas as compared to normal brain.
27692835	overexpression	Prostate Carcinoma	Here, we show that HDGF is overexpressed in both androgen-sensitive LNCaP cells and androgen-insensitive DU145, 22RV1, and PC-3 cells.
26316779	overexpression	Ovarian Carcinoma	Higher HDGF expression rate was 52.76% in EOC.
26296979	aberrant expression	Colorectal Carcinoma	Significant positive correlation between HDGF expression and β-catenin abnormal expression was found in CRC tissues.
26081074	overexpression	Cholangiocarcinoma	Our previous study demonstrated that high expression levels of HDGF in hilar cholangiocarcinoma tissues correlates with tumor progression and patient outcome.
25938538	overexpression	Liver and Intrahepatic Bile Duct Carcinoma	Hepatoma-derived growth factor (HDGF) overexpression is involved in liver fibrosis and carcinogenesis.
25421244	overexpression	Cervical Adenocarcinoma	The expression of HDGF was significantly increased compared with adjacent non-tumor tissue samples (p < 0.001).
25262276	aberrant expression	Hepatocellular Carcinoma	As a result, we found that HDGF-positive expression rate in IHCC was 51.8% (43/83) in IHCC.
24770635	overexpression	Non-Small Cell Lung Carcinoma	HDGF and ADAM9 were observed highly expressed in NSCLC compared with normal control lung tissues (P < 0.05).
24072730	overexpression	Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor	Kaplan-Meier curves were applied to estimate overall survival, log-rank test was used to assess prognostic relevance of p53 expression with overall survival and Cox regression model was performed to evaluate HRs. p53 expression and high HDGF expression was found in 17 (15.7%) and 55 (50.9%) patients, respectively.
23999841	aberrant expression	Squamous Cell Carcinoma of the Penis	HDGF, VEGF-A, and Ki-67 were positively expressed in 28 (51.9%), 29 (53.7%), and 26 (48.1%) patients, respectively.
23878072	overexpression	Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor	Our results showed that HDGF expression is up-regulated in Ewing's sarcoma.
23793608	overexpression	Cholangiocarcinoma	Positive expression of HDGF was detected in 30 (46.2 %) patients with EHCC and correlated with poor tumor differentiation (P = 0.024).
23609195	overexpression	Gallbladder Carcinoma	In this study, we focused on the clinical significance and biological functions of HDGF in GBC and found that Nuclear HDGF protein overexpression was frequently detected in GBC tissues.
23536873	overexpression	Melanoma	In this study, human melanoma cell lines (A375, A2058, MEL-RM and MM200) showed higher levels of HDGF gene expression, whereas human epidermal melanocytes (HEMn) expressed less.
22576797	overexpression	Glioma	We previously found that HDGF is overexpressed in glioma tissues and that its expression level may correlate with the clinical pathological grade.
22361040	overexpression	Lip and Oral Cavity Carcinoma	HDGF expression was higher in malignant oral cancer cells than benign ones.
22331796	overexpression	Glioblastoma	Western blot analysis confirmed HDGF overexpression in GSCs as well as its presence in GSC-conditioned medium, while, in contrast, no HDGF was detected in NSC secretome.
22247069	overexpression	Breast Carcinoma	Immunoblot and immunohistochemical studies revealed elevated HDGF expression in human breast cancer cell lines and tissues.
22006999	overexpression	Gastric Carcinoma; Breast Carcinoma; Lung Carcinoma	Interestingly, we found that HDGF was overexpressed also in primary gastric, breast, and lung cancer tissues harboring mutant p53 genes.
21426662	overexpression	Non-Small Cell Lung Carcinoma	HDGF was found significantly highly expressed in 158 NSCLC tissues compared with normal control lung tissues (P < 0.001).
21255068	overexpression	Nasopharyngeal Carcinoma	Overexpressed mRNA and HDGF protein was present in NPC.
20848225	aberrant expression	Hilar Cholangiocarcinoma	HDGF and VEGF were positively expressed in 27 (46.6%) and 42 (72.4%) patients, respectively.
20846397	overexpression	Hepatocellular Carcinoma	Protein expression level of HDGF was markedly higher in HCC tissues than that in the normal liver tissues(P = 0.011).
20193688	overexpression	Lung Carcinoma	The HDGF average level in serum samples from lung cancer patients is significantly elevated relative to that from healthy controls, 9.43+/-6.13 ng/ml versus 4.36+/-2.50 ng/ml (p=1.12E-10).
19435872	overexpression	Lung Carcinoma	Hepatoma-derived growth factor (HDGF) is overexpressed in lung cancer and the overexpression correlates with aggressive biological behaviors and poor clinical outcomes.
19279430	aberrant expression	Colorectal Gastrointestinal Stromal Tumor	HDGF immunostaining was found in the nucleus (20-95 percent) as well as in the cytoplasm (weak: 16; intermediate: 17; strong: 19). Upregulation of nuclear HDGF levels existed in increased cytoplasmic HDGF levels (P < 0.001).
19214667	overexpression	Hepatocellular Carcinoma	Hepatoma-derived growth factor (HDGF) is a unique nuclear targeting growth factor that is highly expressed in HCC cells and is a possible prognostic factor for patients with HCC.
18478933	overexpression	Non-Small Cell Lung Carcinoma	HDGF expression was observed in all cases, and significantly higher than that in normal lung tissues (52.23 +/- 10.35 vs. 156.73 +/- 70.95, P < 0.01).
21122296	overexpression	Non-Small Cell Lung Carcinoma	HDGF positively staining was seen in all patients, and remarkably higher than that in normal lung tissues (52.23±10.35 vs 156.73±70.95, P < 0.01).
16397032	overexpression	Gastric Carcinoma	Samples with >90% of tumor cells to express positive immunoreactivity similar to or stronger than that in endothelial cells both for nucleus and cytoplasm were regarded as HDGF index level 2, and others as HDGF index level 1.
15604097	overexpression	Colorectal Carcinoma	HDGF expression is dramatically increased in human colorectal cancers, especially in tumors proficient in DNA mismatch repair, and thus represents a novel marker for a distinctive tumor subtype.
14583466	overexpression	Melanoma	In contrast, Western analysis of HDGF demonstrated increased expression of all forms in melanoma cell lines compared with melanocytes.
14535987	overexpression	Hepatocellular Carcinoma	Using immunohistochemistry with the specific anti-HDGF antibody, HDGF was more strongly and frequently expressed in the nucleus and cytoplasm of HCC cells than in the adjacent normal hepatocytes.
14508832	overexpression	Hepatocellular Carcinoma	RT-PCR and Western blot analysis detected increased HDGF expression in malignant hepatoma cell lines.
28592712	Overexpression	Non-small Cell Lung Carcinoma	The high expression of HDGF in non-small cell lung cancer (NSCLC) tissues is associated with unfavorable prognosis.
27692835	Overexpression	Prostate Carcinoma	Here, we show that HDGF is overexpressed in both androgen-sensitive LNCaP cells and androgen-insensitive DU145, 22RV1, and PC-3 cells.

Summary
Symbol	HDGF
Name	heparin binding growth factor
Aliases	HMG1L2; high-mobility group protein 1-like; hepatoma-derived growth factor (high-mobility group protein 1-li ......
Location	1q23.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.443	8.08e-21	6.9	48.5	44.6	Gain
BRCA	Breast invasive carcinoma	1075	0.548	2.25e-85	2	26	72	Gain
CESC	Cervical and endocervical cancers	292	0.5	7.22e-20	2.1	43.8	54.1	Gain
COAD	Colon adenocarcinoma	449	0.343	7.73e-14	9.1	69.9	20.9	Neutral
ESCA	Esophageal carcinoma	183	0.467	2.71e-11	4.4	46.4	49.2	Gain
GBM	Glioblastoma multiforme	147	0.472	1.56e-09	2	78.9	19	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.304	1.9e-12	7.2	67.3	25.5	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.589	2.75e-50	6.5	81.9	11.6	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.496	2.86e-19	6.9	87.5	5.6	Neutral
LAML	Acute Myeloid Leukemia	166	0.075	0.339	0	98.8	1.2	Neutral
LGG	Brain Lower Grade Glioma	513	0.224	3.11e-07	1.9	90.1	8	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.562	1.16e-31	0.3	25	74.7	Gain
LUAD	Lung adenocarcinoma	512	0.468	3.27e-29	2.1	26	71.9	Gain
LUSC	Lung squamous cell carcinoma	498	0.525	1.17e-36	5	43	52	Gain
OV	Ovarian serous cystadenocarcinoma	300	0.429	7.76e-15	3.3	37.3	59.3	Gain
PAAD	Pancreatic adenocarcinoma	177	0.618	5.36e-20	3.4	63.8	32.8	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.567	3.54e-15	8.6	74.7	16.7	Neutral
PRAD	Prostate adenocarcinoma	491	0.454	2.77e-26	3.3	90.6	6.1	Neutral
READ	Rectum adenocarcinoma	164	0.324	2.34e-05	7.9	63.4	28.7	Neutral
SARC	Sarcoma	255	0.521	4.13e-19	7.5	56.5	36.1	Gain
SKCM	Skin Cutaneous Melanoma	367	0.542	2.33e-29	4.1	41.7	54.2	Gain
STAD	Stomach adenocarcinoma	413	0.424	1.94e-19	2.7	61.7	35.6	Gain
TGCT	Testicular Germ Cell Tumors	150	0.453	5.62e-09	0.7	54	45.3	Gain
THCA	Thyroid carcinoma	497	0.434	3.17e-24	0.6	94	5.4	Neutral
THYM	Thymoma	119	0.198	0.0307	0	79.8	20.2	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.327	7.24e-15	0.2	54.7	45.1	Gain

Summary
Symbol	HDGF
Name	heparin binding growth factor
Aliases	HMG1L2; high-mobility group protein 1-like; hepatoma-derived growth factor (high-mobility group protein 1-li ......
Location	1q23.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.107	0.0268	17	408	-0.002	0.0196	NS/NA
BRCA	Breast invasive carcinoma	-0.171	4.11e-07	83	785	0	0.22	NS/NA
CESC	Cervical and endocervical cancers	-0.131	0.021	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.086	0.128	19	297	0.001	0.004	NS/NA
ESCA	Esophageal carcinoma	-0.209	0.00349	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.379	0.00197	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.159	0.000215	20	522	-0.003	0.0297	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.151	0.00505	24	319	0.001	0.00223	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.108	0.0615	23	275	0	0.00934	NS/NA
LAML	Acute Myeloid Leukemia	-0.104	0.176	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.17	8.33e-05	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.253	2.12e-07	41	373	0	0.468	NS/NA
LUAD	Lung adenocarcinoma	-0.13	0.00439	21	456	-0.007	0.84	NS/NA
LUSC	Lung squamous cell carcinoma	-0.17	0.000889	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.833	0.00827	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.172	0.0201	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.239	0.000999	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.211	9.47e-07	35	498	-0.013	2.14e-09	NS/NA
READ	Rectum adenocarcinoma	-0.238	0.0167	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.178	0.00386	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.174	0.000144	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.079	0.13	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.289	0.000272	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.114	0.00689	50	509	-0.002	0.919	NS/NA
THYM	Thymoma	-0.161	0.0772	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.109	0.0184	34	431	-0.002	0.00155	NS/NA

Summary
Symbol	HDGF
Name	heparin binding growth factor
Aliases	HMG1L2; high-mobility group protein 1-like; hepatoma-derived growth factor (high-mobility group protein 1-li ......
Location	1q23.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	3	High
Appendix	3	High
Bone marrow	3	High
Breast	3	High
Bronchus	3	High
Caudate	2	Medium
Cerebellum	3	High
Cerebral cortex	2	Medium
Cervix, uterine	3	High
Colon	3	High
Duodenum	3	High
Endometrium	3	High
Epididymis	3	High
Esophagus	3	High
Fallopian tube	3	High
Gallbladder	3	High
Heart muscle	3	High
Hippocampus	2	Medium
Kidney	3	High
Liver	2	Medium
Lung	3	High
Lymph node	3	High
Nasopharynx	3	High
Oral mucosa	3	High
Ovary	2	Medium
Pancreas	3	High
Parathyroid gland	2	Medium
Placenta	3	High
Prostate	3	High
Rectum	3	High
Salivary gland	3	High
Seminal vesicle	3	High
Skeletal muscle	3	High
Skin	3	High
Small intestine	3	High
Smooth muscle	3	High
Soft tissue	3	High
Spleen	2	Medium
Stomach	3	High
Testis	3	High
Thyroid gland	3	High
Tonsil	3	High
Urinary bladder	3	High
Vagina	3	High

Summary
Symbol	HDGF
Name	heparin binding growth factor
Aliases	HMG1L2; high-mobility group protein 1-like; hepatoma-derived growth factor (high-mobility group protein 1-li ......
Location	1q23.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.996	NS	24476821
BRCA	Breast invasive carcinoma	521	3.14e-34	Significant	23000897
COAD	Colon adenocarcinoma	149	0.0072	Significant	22810696
GBM	Glioblastoma multiforme	157	0.000499	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	1.09e-07	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.0766	NS	26536169
LGG	Brain Lower Grade Glioma	513	3.3e-19	Significant	26824661
LUAD	Lung adenocarcinoma	230	1.21e-11	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	0.117	NS	22960745
OV	Ovarian serous cystadenocarcinoma	287	6.59e-06	Significant	21720365
PRAD	Prostate adenocarcinoma	333	0.139	NS	26544944
READ	Rectum adenocarcinoma	67	0.0184	Significant	22810696
SKCM	Skin Cutaneous Melanoma	315	1.24e-05	Significant	26091043
STAD	Stomach adenocarcinoma	277	3.86e-12	Significant	25079317
THCA	Thyroid carcinoma	391	3.23e-19	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	1.64e-11	Significant	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	1.146	0.531	NS
BRCA	Breast invasive carcinoma	1079	0.993	0.975	NS
CESC	Cervical and endocervical cancers	291	1.7	0.117	NS
COAD	Colon adenocarcinoma	439	0.999	0.999	NS
ESCA	Esophageal carcinoma	184	1.196	0.595	NS
GBM	Glioblastoma multiforme	158	0.723	0.216	NS
HNSC	Head and Neck squamous cell carcinoma	518	0.94	0.746	NS
KIRC	Kidney renal clear cell carcinoma	531	1.123	0.585	NS
KIRP	Kidney renal papillary cell carcinoma	287	2.526	0.0455	Shorter
LAML	Acute Myeloid Leukemia	149	0.95	0.841	NS
LGG	Brain Lower Grade Glioma	511	0.868	0.582	NS
LIHC	Liver hepatocellular carcinoma	365	1.929	0.00729	Shorter
LUAD	Lung adenocarcinoma	502	1.319	0.195	NS
LUSC	Lung squamous cell carcinoma	494	0.825	0.346	NS
OV	Ovarian serous cystadenocarcinoma	303	0.801	0.288	NS
PAAD	Pancreatic adenocarcinoma	177	2.364	0.00543	Shorter
PCPG	Pheochromocytoma and Paraganglioma	179	559210899.075	0.0932	NS
PRAD	Prostate adenocarcinoma	497	3.58	0.227	NS
READ	Rectum adenocarcinoma	159	0.737	0.596	NS
SARC	Sarcoma	259	1.496	0.171	NS
SKCM	Skin Cutaneous Melanoma	459	1.934	6e-04	Shorter
STAD	Stomach adenocarcinoma	388	0.663	0.0643	NS
TGCT	Testicular Germ Cell Tumors	134	1	1	NS
THCA	Thyroid carcinoma	500	0.705	0.623	NS
THYM	Thymoma	119	0.435	0.323	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	3.023	0.000575	Shorter

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	0.096	0.0542	NS
BRCA	Breast invasive carcinoma	1071	0.001	0.963	NS
CESC	Cervical and endocervical cancers	167	-0.072	0.358	NS
COAD	Colon adenocarcinoma	445	0.059	0.216	NS
ESCA	Esophageal carcinoma	162	-0.109	0.167	NS
HNSC	Head and Neck squamous cell carcinoma	448	0.027	0.574	NS
KIRC	Kidney renal clear cell carcinoma	531	0.114	0.00848	Higher
KIRP	Kidney renal papillary cell carcinoma	260	0.218	0.000391	Higher
LIHC	Liver hepatocellular carcinoma	347	-0.006	0.913	NS
LUAD	Lung adenocarcinoma	507	0.118	0.00777	Higher
LUSC	Lung squamous cell carcinoma	497	0.072	0.108	NS
OV	Ovarian serous cystadenocarcinoma	302	-0.023	0.688	NS
PAAD	Pancreatic adenocarcinoma	176	0.182	0.0155	Higher
READ	Rectum adenocarcinoma	156	0.111	0.169	NS
SKCM	Skin Cutaneous Melanoma	410	-0.013	0.786	NS
STAD	Stomach adenocarcinoma	392	-0.149	0.00304	Lower
TGCT	Testicular Germ Cell Tumors	81	0.332	0.00243	Higher
THCA	Thyroid carcinoma	499	0.143	0.00141	Higher
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.146	0.00107	Higher

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	0.091	0.136	NS
HNSC	Head and Neck squamous cell carcinoma	498	0.049	0.273	NS
KIRC	Kidney renal clear cell carcinoma	525	0.13	0.00295	Higher
LGG	Brain Lower Grade Glioma	514	0.113	0.01	Higher
LIHC	Liver hepatocellular carcinoma	366	0.158	0.00238	Higher
OV	Ovarian serous cystadenocarcinoma	296	-0.005	0.929	NS
PAAD	Pancreatic adenocarcinoma	176	0.203	0.00685	Higher
STAD	Stomach adenocarcinoma	406	-0.212	1.7e-05	Lower
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.424	1.01e-24	Higher

Summary
Symbol	HDGF
Name	heparin binding growth factor
Aliases	HMG1L2; high-mobility group protein 1-like; hepatoma-derived growth factor (high-mobility group protein 1-li ......
Location	1q23.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	HDGF
Name	heparin binding growth factor
Aliases	HMG1L2; high-mobility group protein 1-like; hepatoma-derived growth factor (high-mobility group protein 1-li ......
Location	1q23.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for HDGF.

Summary
Symbol	HDGF
Name	heparin binding growth factor
Aliases	HMG1L2; high-mobility group protein 1-like; hepatoma-derived growth factor (high-mobility group protein 1-li ......
Location	1q23.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

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PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
27692835	Prostate Carcinoma	downstream	phospho-AKT; NF-kB	regulation	Western blot analysis also showed that HDGF overexpression modulated the activity of phospho-AKT as well as NF-kB, and these results correlated with in vitro migration and invasion assays.
26296979	Colorectal Carcinoma	partner	CTNNB1	positive correlation	HDGF knock-down dramatically suppressed β-catenin and its down-stream genes expression in CRC cells. Intriguingly, β-catenin knock-down dramatically suppressed HDGF expression in CRC cells.
24770635	Non-Small Cell Lung Carcinoma	partner	ADAM9	positive correlation	Pearson's correlation analysis revealed that ADAM9 expression was correlated positively and significantly with HDGF expression in 63 cases of stage I NSCLC (r = 0.547, P = 0.000).
24072730	Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor	partner	p53	positive correlation	A significant positive correlation was found between p53 expression and HDGF expression in EFT (p=0.022).
22006999	Gastric Carcinoma; Breast Carcinoma; Lung Carcinoma	partner	p53	correlation	Endogenous HDGF expression was decreased in cancer cells with introduction of wild-type p53, which also downregulated HDGF expression after DNA damage. Interestingly, we found that HDGF was overexpressed also in primary gastric, breast, and lung cancer tissues harboring mutant p53 genes.
27692835	Prostate Carcinoma	downstream	Cyclin E; BCL-2; BAX	Positive regulation; Positive regulation; Negative regulation	We also show that HDGF may serve as a survival-related protein as ectopic overexpression of HDGF in RWPE cells up-regulated the expression of antiapoptosis proteins cyclin E and BCL-2, whereas simultaneously down-regulating proapoptotic protein BAX.