CR2Cancer

Summary
Symbol	ING2
Name	inhibitor of growth family member 2
Aliases	p33ING2; ING1L; inhibitor of growth family, member 1-like; ING1Lp; inhibitor of growth 1-like protein; Inhib ......
Location	4q35.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

[ TOP ]

Domain

PF12998 Inhibitor of growth proteins N-terminal histone-binding

Function

Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs).

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification read	#	H3K4me3	#	16728974

> Gene Ontology [ TOP ]
Biological Process	GO:0006476 protein deacetylation GO:0007126 meiotic nuclear division GO:0007127 meiosis I GO:0007140 male meiosis GO:0007141 male meiosis I GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007179 transforming growth factor beta receptor signaling pathway GO:0007281 germ cell development GO:0007283 spermatogenesis GO:0007286 spermatid development GO:0007548 sex differentiation GO:0007568 aging GO:0007569 cell aging GO:0008356 asymmetric cell division GO:0008406 gonad development GO:0008584 male gonad development GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage GO:0016570 histone modification GO:0016575 histone deacetylation GO:0017015 regulation of transforming growth factor beta receptor signaling pathway GO:0017145 stem cell division GO:0022412 cellular process involved in reproduction in multicellular organism GO:0030317 flagellated sperm motility GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway GO:0031056 regulation of histone modification GO:0031058 positive regulation of histone modification GO:0031063 regulation of histone deacetylation GO:0031065 positive regulation of histone deacetylation GO:0035601 protein deacylation GO:0042078 germ-line stem cell division GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0045137 development of primary sexual characteristics GO:0046546 development of primary male sexual characteristics GO:0046661 male sex differentiation GO:0048133 male germ-line stem cell asymmetric division GO:0048232 male gamete generation GO:0048515 spermatid differentiation GO:0048608 reproductive structure development GO:0051321 meiotic cell cycle GO:0061458 reproductive system development GO:0071559 response to transforming growth factor beta GO:0071560 cellular response to transforming growth factor beta stimulus GO:0072331 signal transduction by p53 class mediator GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator GO:0072520 seminiferous tubule development GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway GO:0090287 regulation of cellular response to growth factor stimulus GO:0090311 regulation of protein deacetylation GO:0090312 positive regulation of protein deacetylation GO:0090342 regulation of cell aging GO:0090398 cellular senescence GO:0097193 intrinsic apoptotic signaling pathway GO:0097722 sperm motility GO:0098722 asymmetric stem cell division GO:0098728 germline stem cell asymmetric division GO:0098732 macromolecule deacylation GO:1901796 regulation of signal transduction by p53 class mediator GO:1901797 negative regulation of signal transduction by p53 class mediator GO:1902165 regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:1902229 regulation of intrinsic apoptotic signaling pathway in response to DNA damage GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage GO:1902253 regulation of intrinsic apoptotic signaling pathway by p53 class mediator GO:1902254 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator GO:1902275 regulation of chromatin organization GO:1902532 negative regulation of intracellular signal transduction GO:1903046 meiotic cell cycle process GO:1903844 regulation of cellular response to transforming growth factor beta stimulus GO:1903846 positive regulation of cellular response to transforming growth factor beta stimulus GO:1905269 positive regulation of chromatin organization GO:2000772 regulation of cellular senescence GO:2001020 regulation of response to DNA damage stimulus GO:2001021 negative regulation of response to DNA damage stimulus GO:2001233 regulation of apoptotic signaling pathway GO:2001234 negative regulation of apoptotic signaling pathway GO:2001242 regulation of intrinsic apoptotic signaling pathway GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
Molecular Function	GO:0003682 chromatin binding GO:0005543 phospholipid binding GO:0035064 methylated histone binding GO:0035091 phosphatidylinositol binding GO:0042393 histone binding
Cellular Component	GO:0000118 histone deacetylase complex GO:0000785 chromatin GO:0000790 nuclear chromatin GO:0005667 transcription factor complex GO:0016580 Sin3 complex GO:0016602 CCAAT-binding factor complex GO:0044454 nuclear chromosome part GO:0044798 nuclear transcription factor complex GO:0070822 Sin3-type complex GO:0090575 RNA polymerase II transcription factor complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-6811555: PI5P Regulates TP53 Acetylation R-HSA-5633007: Regulation of TP53 Activity R-HSA-6804758: Regulation of TP53 Activity through Acetylation R-HSA-3700989: Transcriptional Regulation by TP53

Summary
Symbol	ING2
Name	inhibitor of growth family member 2
Aliases	p33ING2; ING1L; inhibitor of growth family, member 1-like; ING1Lp; inhibitor of growth 1-like protein; Inhib ......
Location	4q35.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM4331132	c.173-1G>A	p.?	Unknown	Skin
COSM5756461	c.613T>C	p.F205L	Substitution - Missense	Large_intestine
COSM5095311	c.833G>A	p.R278K	Substitution - Missense	Thymus
COSM75012	c.759G>T	p.W253C	Substitution - Missense	Ovary
COSM3917516	c.745C>T	p.P249S	Substitution - Missense	Skin
COSM1053622	c.760T>C	p.Y254H	Substitution - Missense	Endometrium
COSM447656	c.39C>T	p.A13A	Substitution - coding silent	Thyroid
COSM261422	c.202G>A	p.E68K	Substitution - Missense	Large_intestine
COSM4963845	c.696G>T	p.Q232H	Substitution - Missense	Pancreas
COSM3946220	c.749A>G	p.K250R	Substitution - Missense	Lung
COSM1671449	c.457C>A	p.R153S	Substitution - Missense	Large_intestine
COSM4963845	c.696G>T	p.Q232H	Substitution - Missense	Pancreas
COSM3940821	c.398G>A	p.R133Q	Substitution - Missense	Oesophagus
COSM3602381	c.340C>T	p.R114W	Substitution - Missense	Skin
COSM1736770	c.642C>G	p.Y214*	Substitution - Nonsense	Central_nervous_system
COSM3602382	c.786T>A	p.N262K	Substitution - Missense	Skin
COSM1428809	c.445T>C	p.S149P	Substitution - Missense	Large_intestine
COSM5078277	c.521A>G	p.D174G	Substitution - Missense	Large_intestine
COSM3338190	c.515A>C	p.D172A	Substitution - Missense	Bone
COSM5995438	c.242G>A	p.R81H	Substitution - Missense	Prostate
COSM1053621	c.605C>T	p.P202L	Substitution - Missense	Endometrium
COSM4928865	c.469A>G	p.T157A	Substitution - Missense	Liver
COSM3338189	c.514G>T	p.D172Y	Substitution - Missense	Bone
COSM4390133	c.475G>A	p.E159K	Substitution - Missense	Urinary_tract
COSM5652793	c.624T>G	p.D208E	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3380880	c.54G>A	p.G18G	Substitution - coding silent	Pancreas
COSM1428813	c.819delA	p.K275fs*>6	Deletion - Frameshift	Large_intestine
COSM3825584	c.602C>T	p.S201L	Substitution - Missense	Breast
COSM1695293	c.116_117CC>TT	p.P39L	Substitution - Missense	Skin
COSM1285541	c.412G>C	p.A138P	Substitution - Missense	Autonomic_ganglia
COSM325550	c.469A>T	p.T157S	Substitution - Missense	Lung
COSM4999509	c.232C>A	p.Q78K	Substitution - Missense	Pancreas
COSM1738957	c.120C>G	p.H40Q	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4123656	c.245T>C	p.L82P	Substitution - Missense	Stomach
COSM5639504	c.1A>G	p.M1V	Substitution - Missense	Oesophagus
COSM1053619	c.266C>T	p.A89V	Substitution - Missense	Endometrium
COSM1671449	c.457C>A	p.R153S	Substitution - Missense	Large_intestine
COSM1053620	c.325G>T	p.E109*	Substitution - Nonsense	Endometrium
COSM4549231	c.467G>C	p.R156P	Substitution - Missense	Skin
COSM4331132	c.173-1G>A	p.?	Unknown	Skin
COSM1428810	c.679G>A	p.G227R	Substitution - Missense	Large_intestine
COSM5995439	c.325G>A	p.E109K	Substitution - Missense	Prostate
COSM4123657	c.778G>T	p.G260*	Substitution - Nonsense	Stomach
COSM732954	c.610G>C	p.E204Q	Substitution - Missense	Lung
COSM1738957	c.120C>G	p.H40Q	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3602380	c.309T>A	p.I103I	Substitution - coding silent	Skin
COSM261422	c.202G>A	p.E68K	Substitution - Missense	Central_nervous_system
COSM214077	c.278G>C	p.S93T	Substitution - Missense	Breast
COSM311997	c.200A>G	p.Y67C	Substitution - Missense	Lung

> Text Mining based Variations

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PMID	Variation	Cancer	Evidence
18998165	Mutation	Head and Neck Squamous Cell Carcinoma	The high percentage of LOH suggests ING2 as a candidate TSG in HNSCC.
15005689	Mutation	Basal Cell Carcinoma	Loss of heterozygosity on chromosome 4q32-35 in sporadic basal cell carcinomas: evidence for the involvement of p33ING2/ING1L and SAP30 genes. Further analyses indicate that the minimal deleted region in 4q32-35 includes p33ING2/ING1L and SAP30, whose deletion could impair the G1-phase checkpoint control and favor gene silencing, respectively.

Summary
Symbol	ING2
Name	inhibitor of growth family member 2
Aliases	p33ING2; ING1L; inhibitor of growth family, member 1-like; ING1Lp; inhibitor of growth 1-like protein; Inhib ......
Location	4q35.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM) [ TOP ]
There is no PTM data

Summary
Symbol	ING2
Name	inhibitor of growth family member 2
Aliases	p33ING2; ING1L; inhibitor of growth family, member 1-like; ING1Lp; inhibitor of growth 1-like protein; Inhib ......
Location	4q35.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	3.245	3.29	0.065	0.714	NS
BRCA	Breast invasive carcinoma	112	1100	3.2	3.601	0.371	4.73e-10	NS
CESC	Cervical and endocervical cancers	3	306	2.893	3.996	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	3.218	3.035	-0.249	0.00521	NS
ESCA	Esophageal carcinoma	11	185	3.331	3.107	-0.27	0.246	NS
GBM	Glioblastoma multiforme	5	166	3.05	3.597	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	3.495	3.504	0.006	0.957	NS
KIRC	Kidney renal clear cell carcinoma	72	534	3.147	3.215	0.123	0.058	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	3.14	3.182	0.008	0.94	NS
LAML	Acute Myeloid Leukemia	0	173	NA	3.686	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	3.258	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	2.51	2.343	-0.202	0.0361	NS
LUAD	Lung adenocarcinoma	59	517	3.406	3.351	-0.101	0.212	NS
LUSC	Lung squamous cell carcinoma	51	501	3.401	3.294	-0.073	0.426	NS
OV	Ovarian serous cystadenocarcinoma	0	307	NA	3.085	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	3.371	3.429	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	5.298	2.553	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	3.178	3.282	0.159	0.0115	NS
READ	Rectum adenocarcinoma	10	167	3.201	2.911	-0.31	0.102	NS
SARC	Sarcoma	2	263	3.394	3.494	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	3.244	2.929	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	3.37	3.02	-0.434	5.44e-05	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	4.224	NA	NA	NA
THCA	Thyroid carcinoma	59	509	3.659	3.69	0.022	0.759	NS
THYM	Thymoma	2	120	3.832	4.502	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	3.13	3.478	0.319	0.00342	NS

> Cancer Cell Line Encyclopedia (CCLE)

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Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	8.1
Autonomic ganglia	CHP212	8.7
Autonomic ganglia	IMR32	8
Autonomic ganglia	KELLY	9
Autonomic ganglia	KPNRTBM1	8.1
Autonomic ganglia	KPNSI9S	8.5
Autonomic ganglia	KPNYN	9
Autonomic ganglia	MHHNB11	9.2
Autonomic ganglia	NB1	8.6
Autonomic ganglia	NH6	9
Autonomic ganglia	SHSY5Y	9.1
Autonomic ganglia	SIMA	8.9
Autonomic ganglia	SKNAS	9.8
Autonomic ganglia	SKNBE2	8.2
Autonomic ganglia	SKNDZ	8.6
Autonomic ganglia	SKNFI	8.9
Autonomic ganglia	SKNSH	9.4
Biliary tract	HUCCT1	9.6
Biliary tract	HUH28	8.1
Biliary tract	SNU1079	7.4
Biliary tract	SNU1196	8.8
Biliary tract	SNU245	8.8
Biliary tract	SNU308	9.3
Biliary tract	SNU478	8.8
Bone	143B	9.9
Bone	A673	9.4
Bone	CADOES1	8.8
Bone	CAL78	9.3
Bone	G292CLONEA141B1	10.3
Bone	HOS	9.6
Bone	HS706T	9.4
Bone	HS737T	9.4
Bone	HS819T	9.1
Bone	HS821T	9
Bone	HS822T	8.9
Bone	HS863T	8.9
Bone	HS870T	9.7
Bone	HS888T	8.9
Bone	MG63	9.5
Bone	MHHES1	8.8
Bone	OUMS27	8.6
Bone	RDES	8.5
Bone	SJSA1	9.1
Bone	SKES1	9.2
Bone	SKNMC	9.4
Bone	SW1353	9.7
Bone	T173	9.4
Bone	TC71	9.9
Bone	U2OS	10.3
Breast	AU565	9.3
Breast	BT20	9.2
Breast	BT474	10.6
Breast	BT483	9.8
Breast	BT549	9.1
Breast	CAL120	8.8
Breast	CAL148	9.5
Breast	CAL51	9.1
Breast	CAL851	7.8
Breast	CAMA1	10.6
Breast	DU4475	10
Breast	EFM192A	10.3
Breast	EFM19	9.5
Breast	EVSAT	10
Breast	HCC1143	9.1
Breast	HCC1187	9.1
Breast	HCC1395	8.9
Breast	HCC1419	9.5
Breast	HCC1428	9
Breast	HCC1500	8.5
Breast	HCC1569	9.8
Breast	HCC1599	8.4
Breast	HCC1806	8.7
Breast	HCC1937	10.2
Breast	HCC1954	9.1
Breast	HCC202	10.3
Breast	HCC2157	9.4
Breast	HCC2218	9.7
Breast	HCC38	10.8
Breast	HCC70	9.5
Breast	HDQP1	9.1
Breast	HMC18	8.9
Breast	HS274T	8.5
Breast	HS281T	8.9
Breast	HS343T	8.7
Breast	HS578T	9.3
Breast	HS606T	8.7
Breast	HS739T	9.1
Breast	HS742T	8.7
Breast	JIMT1	7.9
Breast	KPL1	8.9
Breast	MCF7	9
Breast	MDAMB134VI	8.8
Breast	MDAMB157	9.7
Breast	MDAMB175VII	9.6
Breast	MDAMB231	10.2
Breast	MDAMB361	9.8
Breast	MDAMB415	8.8
Breast	MDAMB436	9.1
Breast	MDAMB453	10.1
Breast	MDAMB468	9.3
Breast	SKBR3	9.4
Breast	T47D	9.3
Breast	UACC812	8.4
Breast	UACC893	9.8
Breast	YMB1	9.9
Breast	ZR751	10.1
Breast	ZR7530	9.3
Central nervous system	1321N1	9.7
Central nervous system	42MGBA	9.4
Central nervous system	8MGBA	9.3
Central nervous system	A172	9.1
Central nervous system	AM38	9.4
Central nervous system	BECKER	9.6
Central nervous system	CAS1	8.8
Central nervous system	CCFSTTG1	10.1
Central nervous system	D283MED	9.4
Central nervous system	D341MED	7.4
Central nervous system	DAOY	7.9
Central nervous system	DBTRG05MG	8.3
Central nervous system	DKMG	8.2
Central nervous system	GAMG	9.4
Central nervous system	GB1	9
Central nervous system	GI1	8.7
Central nervous system	GMS10	9.6
Central nervous system	GOS3	8.7
Central nervous system	H4	9.2
Central nervous system	HS683	9.5
Central nervous system	KALS1	9.2
Central nervous system	KG1C	8.1
Central nervous system	KNS42	8.5
Central nervous system	KNS60	8.3
Central nervous system	KNS81	8.9
Central nervous system	KS1	10
Central nervous system	LN18	10.1
Central nervous system	LN229	9.3
Central nervous system	M059K	9.7
Central nervous system	MOGGCCM	8.6
Central nervous system	MOGGUVW	9.4
Central nervous system	NMCG1	9.1
Central nervous system	ONS76	8.4
Central nervous system	SF126	9.7
Central nervous system	SF295	9.3
Central nervous system	SNB19	9.7
Central nervous system	SNU1105	8.4
Central nervous system	SNU201	8.2
Central nervous system	SNU466	7.8
Central nervous system	SNU489	8.1
Central nervous system	SNU626	8.7
Central nervous system	SNU738	7.6
Central nervous system	SW1088	9.6
Central nervous system	SW1783	10.1
Central nervous system	T98G	9
Central nervous system	TM31	8.4
Central nervous system	U118MG	9.4
Central nervous system	U138MG	9.3
Central nervous system	U251MG	8.2
Central nervous system	U87MG	9.7
Central nervous system	YH13	9.4
Central nervous system	YKG1	8.5
Endometrium	AN3CA	9.7
Endometrium	COLO684	9.4
Endometrium	EFE184	8.9
Endometrium	EN	9.7
Endometrium	ESS1	9.1
Endometrium	HEC108	8.9
Endometrium	HEC151	9.7
Endometrium	HEC1A	10.5
Endometrium	HEC1B	8
Endometrium	HEC251	9.1
Endometrium	HEC265	10
Endometrium	HEC50B	8.3
Endometrium	HEC59	9.6
Endometrium	HEC6	9.9
Endometrium	ISHIKAWAHERAKLIO02ER	9.8
Endometrium	JHUEM1	9.6
Endometrium	JHUEM2	9.2
Endometrium	JHUEM3	8.8
Endometrium	KLE	9.6
Endometrium	MFE280	8
Endometrium	MFE296	9.7
Endometrium	MFE319	9.9
Endometrium	RL952	9.6
Endometrium	SNGM	10
Endometrium	SNU1077	8.2
Endometrium	SNU685	7.9
Endometrium	TEN	9.1
Haematopoietic and lymphoid	697	9
Haematopoietic and lymphoid	A3KAW	10
Haematopoietic and lymphoid	A4FUK	9.8
Haematopoietic and lymphoid	ALLSIL	9.1
Haematopoietic and lymphoid	AML193	10.3
Haematopoietic and lymphoid	AMO1	7.7
Haematopoietic and lymphoid	BCP1	10.1
Haematopoietic and lymphoid	BDCM	9.2
Haematopoietic and lymphoid	BL41	9.5
Haematopoietic and lymphoid	BL70	10
Haematopoietic and lymphoid	BV173	9.2
Haematopoietic and lymphoid	CA46	9.7
Haematopoietic and lymphoid	CI1	10.2
Haematopoietic and lymphoid	CMK115	9.8
Haematopoietic and lymphoid	CMK86	9.6
Haematopoietic and lymphoid	CMK	9.2
Haematopoietic and lymphoid	CMLT1	8.7
Haematopoietic and lymphoid	COLO775	9.4
Haematopoietic and lymphoid	DAUDI	9.4
Haematopoietic and lymphoid	DB	9.1
Haematopoietic and lymphoid	DEL	9.4
Haematopoietic and lymphoid	DND41	9.5
Haematopoietic and lymphoid	DOHH2	9.3
Haematopoietic and lymphoid	EB1	9.5
Haematopoietic and lymphoid	EB2	9
Haematopoietic and lymphoid	EHEB	7.6
Haematopoietic and lymphoid	EJM	9.3
Haematopoietic and lymphoid	EM2	9.3
Haematopoietic and lymphoid	EOL1	9.5
Haematopoietic and lymphoid	F36P	9.2
Haematopoietic and lymphoid	GA10	9.9
Haematopoietic and lymphoid	GDM1	9.6
Haematopoietic and lymphoid	GRANTA519	9.4
Haematopoietic and lymphoid	HDLM2	8.9
Haematopoietic and lymphoid	HDMYZ	9.1
Haematopoietic and lymphoid	HEL9217	9.4
Haematopoietic and lymphoid	HEL	9.2
Haematopoietic and lymphoid	HH	8.8
Haematopoietic and lymphoid	HL60	9.8
Haematopoietic and lymphoid	HPBALL	9.7
Haematopoietic and lymphoid	HS604T	8.8
Haematopoietic and lymphoid	HS611T	9.2
Haematopoietic and lymphoid	HS616T	8.7
Haematopoietic and lymphoid	HS751T	8.9
Haematopoietic and lymphoid	HT	9.5
Haematopoietic and lymphoid	HTK	9
Haematopoietic and lymphoid	HUNS1	9.3
Haematopoietic and lymphoid	HUT102	9
Haematopoietic and lymphoid	HUT78	9.4
Haematopoietic and lymphoid	JEKO1	9.8
Haematopoietic and lymphoid	JK1	8.6
Haematopoietic and lymphoid	JM1	9.2
Haematopoietic and lymphoid	JURKAT	9.7
Haematopoietic and lymphoid	JURLMK1	9.7
Haematopoietic and lymphoid	JVM2	8.3
Haematopoietic and lymphoid	JVM3	8.1
Haematopoietic and lymphoid	K562	9
Haematopoietic and lymphoid	KARPAS299	9.3
Haematopoietic and lymphoid	KARPAS422	8
Haematopoietic and lymphoid	KARPAS620	9
Haematopoietic and lymphoid	KASUMI1	9.8
Haematopoietic and lymphoid	KASUMI2	8.7
Haematopoietic and lymphoid	KASUMI6	9.2
Haematopoietic and lymphoid	KCL22	9.1
Haematopoietic and lymphoid	KE37	9.5
Haematopoietic and lymphoid	KE97	9.2
Haematopoietic and lymphoid	KG1	9
Haematopoietic and lymphoid	KHM1B	9.7
Haematopoietic and lymphoid	KIJK	9.3
Haematopoietic and lymphoid	KMH2	7.7
Haematopoietic and lymphoid	KMM1	9.3
Haematopoietic and lymphoid	KMS11	10.1
Haematopoietic and lymphoid	KMS12BM	9.2
Haematopoietic and lymphoid	KMS18	8.8
Haematopoietic and lymphoid	KMS20	10.2
Haematopoietic and lymphoid	KMS21BM	8.7
Haematopoietic and lymphoid	KMS26	9.3
Haematopoietic and lymphoid	KMS27	9.5
Haematopoietic and lymphoid	KMS28BM	9.5
Haematopoietic and lymphoid	KMS34	9.9
Haematopoietic and lymphoid	KO52	9.5
Haematopoietic and lymphoid	KOPN8	8.6
Haematopoietic and lymphoid	KU812	10.4
Haematopoietic and lymphoid	KYO1	9.3
Haematopoietic and lymphoid	L1236	9
Haematopoietic and lymphoid	L363	9.3
Haematopoietic and lymphoid	L428	9.7
Haematopoietic and lymphoid	L540	9.3
Haematopoietic and lymphoid	LAMA84	9.2
Haematopoietic and lymphoid	LOUCY	10.3
Haematopoietic and lymphoid	LP1	8.3
Haematopoietic and lymphoid	M07E	9.2
Haematopoietic and lymphoid	MC116	10.3
Haematopoietic and lymphoid	ME1	9.7
Haematopoietic and lymphoid	MEC1	8.7
Haematopoietic and lymphoid	MEC2	8.7
Haematopoietic and lymphoid	MEG01	10.2
Haematopoietic and lymphoid	MHHCALL2	8.8
Haematopoietic and lymphoid	MHHCALL3	9.2
Haematopoietic and lymphoid	MHHCALL4	9.2
Haematopoietic and lymphoid	MINO	9
Haematopoietic and lymphoid	MJ	8.9
Haematopoietic and lymphoid	MM1S	10
Haematopoietic and lymphoid	MOLM13	9.1
Haematopoietic and lymphoid	MOLM16	8.5
Haematopoietic and lymphoid	MOLM6	8.7
Haematopoietic and lymphoid	MOLP2	9.3
Haematopoietic and lymphoid	MOLP8	8.4
Haematopoietic and lymphoid	MOLT13	9.1
Haematopoietic and lymphoid	MOLT16	9.3
Haematopoietic and lymphoid	MOLT4	10
Haematopoietic and lymphoid	MONOMAC1	9.2
Haematopoietic and lymphoid	MONOMAC6	9.3
Haematopoietic and lymphoid	MOTN1	8.2
Haematopoietic and lymphoid	MUTZ5	9.6
Haematopoietic and lymphoid	MV411	9.2
Haematopoietic and lymphoid	NALM19	9.1
Haematopoietic and lymphoid	NALM1	9
Haematopoietic and lymphoid	NALM6	9.3
Haematopoietic and lymphoid	NAMALWA	9
Haematopoietic and lymphoid	NB4	9.4
Haematopoietic and lymphoid	NCIH929	9.6
Haematopoietic and lymphoid	NCO2	9.9
Haematopoietic and lymphoid	NOMO1	9.4
Haematopoietic and lymphoid	NUDHL1	8.8
Haematopoietic and lymphoid	NUDUL1	9.1
Haematopoietic and lymphoid	OCIAML2	9.6
Haematopoietic and lymphoid	OCIAML3	9.4
Haematopoietic and lymphoid	OCIAML5	9.8
Haematopoietic and lymphoid	OCILY10	8.9
Haematopoietic and lymphoid	OCILY19	9.5
Haematopoietic and lymphoid	OCILY3	10.2
Haematopoietic and lymphoid	OCIM1	9.1
Haematopoietic and lymphoid	OPM2	9.3
Haematopoietic and lymphoid	P12ICHIKAWA	9.2
Haematopoietic and lymphoid	P31FUJ	9.4
Haematopoietic and lymphoid	P3HR1	9.7
Haematopoietic and lymphoid	PCM6	9.4
Haematopoietic and lymphoid	PEER	10.8
Haematopoietic and lymphoid	PF382	9.5
Haematopoietic and lymphoid	PFEIFFER	7.9
Haematopoietic and lymphoid	PL21	9.5
Haematopoietic and lymphoid	RAJI	10.1
Haematopoietic and lymphoid	RCHACV	8.8
Haematopoietic and lymphoid	REC1	9
Haematopoietic and lymphoid	REH	9.3
Haematopoietic and lymphoid	RI1	9.1
Haematopoietic and lymphoid	RL	9.2
Haematopoietic and lymphoid	RPMI8226	9
Haematopoietic and lymphoid	RPMI8402	10
Haematopoietic and lymphoid	RS411	9.7
Haematopoietic and lymphoid	SEM	9.4
Haematopoietic and lymphoid	SET2	9.5
Haematopoietic and lymphoid	SIGM5	9.2
Haematopoietic and lymphoid	SKM1	10.1
Haematopoietic and lymphoid	SKMM2	8.9
Haematopoietic and lymphoid	SR786	8.4
Haematopoietic and lymphoid	ST486	10.1
Haematopoietic and lymphoid	SUDHL10	9.4
Haematopoietic and lymphoid	SUDHL1	9.1
Haematopoietic and lymphoid	SUDHL4	9.2
Haematopoietic and lymphoid	SUDHL5	9.8
Haematopoietic and lymphoid	SUDHL6	9.5
Haematopoietic and lymphoid	SUDHL8	8.9
Haematopoietic and lymphoid	SUPB15	9.1
Haematopoietic and lymphoid	SUPHD1	8
Haematopoietic and lymphoid	SUPM2	9.7
Haematopoietic and lymphoid	SUPT11	10.4
Haematopoietic and lymphoid	SUPT1	9.8
Haematopoietic and lymphoid	TALL1	9.8
Haematopoietic and lymphoid	TF1	9.3
Haematopoietic and lymphoid	THP1	9.4
Haematopoietic and lymphoid	TO175T	9
Haematopoietic and lymphoid	TOLEDO	10.5
Haematopoietic and lymphoid	U266B1	8.6
Haematopoietic and lymphoid	U937	10.2
Haematopoietic and lymphoid	UT7	9.3
Haematopoietic and lymphoid	WSUDLCL2	9.4
Kidney	769P	9.2
Kidney	786O	7.7
Kidney	A498	8.5
Kidney	A704	8.6
Kidney	ACHN	8.8
Kidney	BFTC909	8.9
Kidney	CAKI1	9.5
Kidney	CAKI2	9.4
Kidney	CAL54	7.8
Kidney	KMRC1	9
Kidney	KMRC20	9.5
Kidney	KMRC2	8.9
Kidney	KMRC3	8.7
Kidney	OSRC2	7.8
Kidney	RCC10RGB	7
Kidney	SNU1272	8.6
Kidney	SNU349	8.8
Kidney	TUHR10TKB	10
Kidney	TUHR14TKB	7.8
Kidney	TUHR4TKB	8.1
Kidney	VMRCRCW	8.9
Kidney	VMRCRCZ	8.9
Large intestine	C2BBE1	8.8
Large intestine	CCK81	9.6
Large intestine	CL11	8.7
Large intestine	CL14	7.9
Large intestine	CL34	8.8
Large intestine	CL40	8.1
Large intestine	COLO205	9.6
Large intestine	COLO320	8.5
Large intestine	COLO678	8.1
Large intestine	CW2	8.9
Large intestine	DLD1	10.1
Large intestine	GP2D	9.8
Large intestine	HCC56	8.7
Large intestine	HCT116	8.5
Large intestine	HCT15	10.1
Large intestine	HS675T	9.1
Large intestine	HS698T	8.6
Large intestine	HT115	9.2
Large intestine	HT29	8.5
Large intestine	HT55	8.6
Large intestine	KM12	9.4
Large intestine	LOVO	9.2
Large intestine	LS1034	8.6
Large intestine	LS123	9.2
Large intestine	LS180	9.5
Large intestine	LS411N	9.7
Large intestine	LS513	8.7
Large intestine	MDST8	8.8
Large intestine	NCIH508	7.1
Large intestine	NCIH716	10
Large intestine	NCIH747	8.7
Large intestine	OUMS23	8.2
Large intestine	RCM1	9
Large intestine	RKO	9.9
Large intestine	SKCO1	8.7
Large intestine	SNU1040	9.1
Large intestine	SNU1197	9.3
Large intestine	SNU175	9.2
Large intestine	SNU283	8.6
Large intestine	SNU407	9.1
Large intestine	SNU503	8.6
Large intestine	SNU61	9
Large intestine	SNU81	8.7
Large intestine	SNUC1	9.1
Large intestine	SNUC2A	9
Large intestine	SNUC4	9.1
Large intestine	SNUC5	8.9
Large intestine	SW1116	8.8
Large intestine	SW1417	8.6
Large intestine	SW1463	8.3
Large intestine	SW403	7.1
Large intestine	SW480	9.7
Large intestine	SW48	9.6
Large intestine	SW620	9.3
Large intestine	SW837	9.3
Large intestine	SW948	8.5
Large intestine	T84	9.4
Liver	ALEXANDERCELLS	8
Liver	C3A	9
Liver	HEP3B217	8.3
Liver	HEPG2	9
Liver	HLE	9.7
Liver	HLF	10.4
Liver	HUH1	9.1
Liver	HUH6	9.2
Liver	HUH7	8.5
Liver	JHH1	9.5
Liver	JHH2	9
Liver	JHH4	9
Liver	JHH5	9.3
Liver	JHH6	8.6
Liver	JHH7	10
Liver	LI7	9.3
Liver	PLCPRF5	9
Liver	SKHEP1	8.6
Liver	SNU182	7
Liver	SNU387	8.7
Liver	SNU398	11
Liver	SNU423	9.4
Liver	SNU449	8.1
Liver	SNU475	8.6
Liver	SNU761	8.1
Liver	SNU878	8.6
Liver	SNU886	9.2
Lung	A549	8.9
Lung	ABC1	10.9
Lung	BEN	7.2
Lung	CAL12T	10.1
Lung	CALU1	9.4
Lung	CALU3	8.7
Lung	CALU6	8.5
Lung	CHAGOK1	9.3
Lung	COLO668	9
Lung	COLO699	8
Lung	CORL105	8.9
Lung	CORL23	9.4
Lung	CORL24	8.4
Lung	CORL279	8.7
Lung	CORL311	8.8
Lung	CORL47	9.6
Lung	CORL51	9.6
Lung	CORL88	8.7
Lung	CORL95	9.3
Lung	CPCN	9.3
Lung	DMS114	10.6
Lung	DMS153	9.6
Lung	DMS273	9.4
Lung	DMS454	8.8
Lung	DMS53	8.9
Lung	DMS79	9.4
Lung	DV90	10.1
Lung	EBC1	9.8
Lung	EPLC272H	9.1
Lung	HARA	9.6
Lung	HCC1171	9.6
Lung	HCC1195	9
Lung	HCC15	8.4
Lung	HCC2279	9.1
Lung	HCC2935	9.3
Lung	HCC33	9.5
Lung	HCC366	8.5
Lung	HCC4006	9
Lung	HCC44	8.1
Lung	HCC78	9.6
Lung	HCC827	9.2
Lung	HCC95	8.2
Lung	HLC1	9.8
Lung	HLFA	9.1
Lung	HS229T	9.7
Lung	HS618T	9.3
Lung	IALM	10.2
Lung	KNS62	8.1
Lung	LC1F	9
Lung	LC1SQSF	9
Lung	LCLC103H	8.1
Lung	LCLC97TM1	8.8
Lung	LK2	8.6
Lung	LOUNH91	8.2
Lung	LU65	9.6
Lung	LU99	9.4
Lung	LUDLU1	9.2
Lung	LXF289	8.9
Lung	MORCPR	8.8
Lung	NCIH1048	9.7
Lung	NCIH1092	9.1
Lung	NCIH1105	8.5
Lung	NCIH1155	9.7
Lung	NCIH1184	9.5
Lung	NCIH1299	8.9
Lung	NCIH1339	9.6
Lung	NCIH1341	10.1
Lung	NCIH1355	9.7
Lung	NCIH1373	10
Lung	NCIH1385	8.5
Lung	NCIH1395	8.6
Lung	NCIH1435	9
Lung	NCIH1436	9.4
Lung	NCIH1437	8.9
Lung	NCIH146	9.7
Lung	NCIH1563	9.2
Lung	NCIH1568	8.6
Lung	NCIH1573	9.6
Lung	NCIH1581	9.2
Lung	NCIH1618	9.7
Lung	NCIH1623	8.5
Lung	NCIH1648	9.3
Lung	NCIH1650	9.6
Lung	NCIH1651	9.6
Lung	NCIH1666	9.7
Lung	NCIH1693	9.7
Lung	NCIH1694	9.7
Lung	NCIH1703	9.7
Lung	NCIH1734	9.8
Lung	NCIH1755	9.9
Lung	NCIH1781	9.6
Lung	NCIH1792	8.9
Lung	NCIH1793	9
Lung	NCIH1836	9.3
Lung	NCIH1838	9.7
Lung	NCIH1869	9.7
Lung	NCIH1876	8.7
Lung	NCIH1915	9.4
Lung	NCIH1930	10
Lung	NCIH1944	9
Lung	NCIH1963	8.9
Lung	NCIH196	9.1
Lung	NCIH1975	9.4
Lung	NCIH2009	9.7
Lung	NCIH2023	9.8
Lung	NCIH2029	8.9
Lung	NCIH2030	8.8
Lung	NCIH2066	8.4
Lung	NCIH2081	8.5
Lung	NCIH2085	9.6
Lung	NCIH2087	9.1
Lung	NCIH209	9.6
Lung	NCIH2106	9.2
Lung	NCIH2110	8.4
Lung	NCIH211	9.3
Lung	NCIH2122	9.2
Lung	NCIH2126	9.4
Lung	NCIH2141	8.1
Lung	NCIH2170	9.2
Lung	NCIH2171	8.4
Lung	NCIH2172	9.4
Lung	NCIH2196	8.1
Lung	NCIH2227	10.3
Lung	NCIH2228	9.9
Lung	NCIH226	9.5
Lung	NCIH2286	10.3
Lung	NCIH2291	9.9
Lung	NCIH2342	8.9
Lung	NCIH2347	10.3
Lung	NCIH23	9
Lung	NCIH2405	9.8
Lung	NCIH2444	9
Lung	NCIH292	9.2
Lung	NCIH322	10.1
Lung	NCIH3255	9.6
Lung	NCIH358	10.5
Lung	NCIH441	9.7
Lung	NCIH446	9.2
Lung	NCIH460	9.5
Lung	NCIH510	9.5
Lung	NCIH520	9.5
Lung	NCIH522	9.9
Lung	NCIH524	8.7
Lung	NCIH526	9.1
Lung	NCIH596	9.4
Lung	NCIH647	9.4
Lung	NCIH650	9.7
Lung	NCIH661	9
Lung	NCIH69	9
Lung	NCIH727	8.3
Lung	NCIH810	8.6
Lung	NCIH82	8.3
Lung	NCIH838	9.1
Lung	NCIH841	9.8
Lung	NCIH854	6.9
Lung	NCIH889	8.4
Lung	PC14	9.7
Lung	RERFLCAD1	9.6
Lung	RERFLCAD2	10.2
Lung	RERFLCAI	9.8
Lung	RERFLCKJ	10.6
Lung	RERFLCMS	9.4
Lung	RERFLCSQ1	9.7
Lung	SBC5	8.8
Lung	SCLC21H	9.7
Lung	SHP77	8.2
Lung	SKLU1	10.3
Lung	SKMES1	9.7
Lung	SQ1	10.3
Lung	SW1271	9.4
Lung	SW1573	8.2
Lung	SW900	8.7
Lung	VMRCLCD	8.6
Lung	VMRCLCP	8.6
Oesophagus	COLO680N	8.8
Oesophagus	ECGI10	9
Oesophagus	KYSE140	8.3
Oesophagus	KYSE150	8.3
Oesophagus	KYSE180	10
Oesophagus	KYSE270	9.2
Oesophagus	KYSE30	8.3
Oesophagus	KYSE410	9.6
Oesophagus	KYSE450	9.2
Oesophagus	KYSE510	9.8
Oesophagus	KYSE520	9
Oesophagus	KYSE70	7.5
Oesophagus	OE19	7.7
Oesophagus	OE33	9.2
Oesophagus	TE10	9.1
Oesophagus	TE11	9.6
Oesophagus	TE14	9
Oesophagus	TE15	9.8
Oesophagus	TE1	8.7
Oesophagus	TE4	9.4
Oesophagus	TE5	8.5
Oesophagus	TE6	9.5
Oesophagus	TE8	8.8
Oesophagus	TE9	9.9
Oesophagus	TT	9.5
Ovary	59M	8.2
Ovary	A2780	10.2
Ovary	CAOV3	9.4
Ovary	CAOV4	8.7
Ovary	COLO704	9.3
Ovary	COV318	8.9
Ovary	COV362	9.9
Ovary	COV434	9.8
Ovary	COV504	9.2
Ovary	COV644	8.4
Ovary	EFO21	7
Ovary	EFO27	9.1
Ovary	ES2	8.7
Ovary	FUOV1	9.5
Ovary	HEYA8	8.9
Ovary	HS571T	8.7
Ovary	IGROV1	10.4
Ovary	JHOC5	9.1
Ovary	JHOM1	9.3
Ovary	JHOM2B	8.7
Ovary	JHOS2	9.7
Ovary	JHOS4	9.6
Ovary	KURAMOCHI	8.4
Ovary	MCAS	9.4
Ovary	NIHOVCAR3	9.9
Ovary	OAW28	8.4
Ovary	OAW42	9.1
Ovary	OC314	9.9
Ovary	OC316	10.2
Ovary	ONCODG1	9.1
Ovary	OV56	10.1
Ovary	OV7	8.7
Ovary	OV90	9.3
Ovary	OVCAR4	9.7
Ovary	OVCAR8	8.8
Ovary	OVISE	9.6
Ovary	OVK18	9.3
Ovary	OVKATE	8.6
Ovary	OVMANA	9.2
Ovary	OVSAHO	9.2
Ovary	OVTOKO	10
Ovary	RMGI	9.5
Ovary	RMUGS	9.5
Ovary	SKOV3	9.6
Ovary	SNU119	10.7
Ovary	SNU840	8.2
Ovary	SNU8	8.5
Ovary	TOV112D	9.4
Ovary	TOV21G	10.1
Ovary	TYKNU	9.4
Pancreas	ASPC1	9.1
Pancreas	BXPC3	9.1
Pancreas	CAPAN1	8.8
Pancreas	CAPAN2	9.9
Pancreas	CFPAC1	9.7
Pancreas	DANG	8.3
Pancreas	HPAC	8.8
Pancreas	HPAFII	9.1
Pancreas	HS766T	8.2
Pancreas	HUPT3	8.9
Pancreas	HUPT4	8.5
Pancreas	KCIMOH1	8.8
Pancreas	KLM1	9.2
Pancreas	KP2	9.1
Pancreas	KP3	8
Pancreas	KP4	9.7
Pancreas	L33	9
Pancreas	MIAPACA2	8.7
Pancreas	PANC0203	8.8
Pancreas	PANC0213	8.4
Pancreas	PANC0327	9.6
Pancreas	PANC0403	10
Pancreas	PANC0504	8.7
Pancreas	PANC0813	8
Pancreas	PANC1005	9.5
Pancreas	PANC1	10.3
Pancreas	PATU8902	8.5
Pancreas	PATU8988S	9.7
Pancreas	PATU8988T	10.5
Pancreas	PK1	9.3
Pancreas	PK45H	8.8
Pancreas	PK59	8.7
Pancreas	PL45	9.9
Pancreas	PSN1	8.8
Pancreas	QGP1	8.9
Pancreas	SNU213	9.2
Pancreas	SNU324	8.3
Pancreas	SNU410	8.2
Pancreas	SU8686	9.3
Pancreas	SUIT2	9.1
Pancreas	SW1990	9.6
Pancreas	T3M4	8.5
Pancreas	TCCPAN2	9.1
Pancreas	YAPC	9.3
Pleura	ACCMESO1	9
Pleura	DM3	8.8
Pleura	ISTMES1	9.6
Pleura	ISTMES2	9.7
Pleura	JL1	7.6
Pleura	MPP89	9.9
Pleura	MSTO211H	9.3
Pleura	NCIH2052	8.9
Pleura	NCIH2452	8.9
Pleura	NCIH28	8.7
Prostate	22RV1	9.3
Prostate	DU145	8.9
Prostate	LNCAPCLONEFGC	8.8
Prostate	MDAPCA2B	9.1
Prostate	NCIH660	9.9
Prostate	PC3	9
Prostate	VCAP	8.6
Salivary gland	A253	9.2
Salivary gland	YD15	9.1
Skin	A101D	9.1
Skin	A2058	8.4
Skin	A375	9.7
Skin	C32	9.3
Skin	CHL1	8.3
Skin	CJM	9.2
Skin	COLO679	9.1
Skin	COLO741	8
Skin	COLO783	8.2
Skin	COLO792	8.3
Skin	COLO800	8.1
Skin	COLO818	8.3
Skin	COLO829	9.3
Skin	COLO849	8.4
Skin	G361	8.1
Skin	GRM	8.9
Skin	HMCB	8.2
Skin	HS294T	9
Skin	HS600T	9
Skin	HS688AT	9.3
Skin	HS695T	8.6
Skin	HS839T	9.4
Skin	HS852T	9.1
Skin	HS895T	9.2
Skin	HS934T	8.8
Skin	HS936T	8.3
Skin	HS939T	9.1
Skin	HS940T	8.7
Skin	HS944T	10.1
Skin	HT144	9.1
Skin	IGR1	8.2
Skin	IGR37	7.9
Skin	IGR39	9
Skin	IPC298	8.7
Skin	K029AX	7.3
Skin	LOXIMVI	9.1
Skin	MALME3M	9
Skin	MDAMB435S	9.2
Skin	MELHO	8.8
Skin	MELJUSO	9.2
Skin	MEWO	7
Skin	RPMI7951	9.4
Skin	RVH421	9.2
Skin	SH4	8.6
Skin	SKMEL1	8.4
Skin	SKMEL24	8
Skin	SKMEL28	8.2
Skin	SKMEL2	9.5
Skin	SKMEL30	8.7
Skin	SKMEL31	8.5
Skin	SKMEL3	8.7
Skin	SKMEL5	8.4
Skin	UACC257	7.7
Skin	UACC62	8
Skin	WM115	8.7
Skin	WM1799	7.1
Skin	WM2664	8.2
Skin	WM793	8.6
Skin	WM88	8.6
Skin	WM983B	8.4
Small intestine	HUTU80	10.3
Soft tissue	A204	10
Soft tissue	G401	9.9
Soft tissue	G402	9
Soft tissue	GCT	9.3
Soft tissue	HS729	8.7
Soft tissue	HT1080	9.6
Soft tissue	KYM1	9.1
Soft tissue	MESSA	9.8
Soft tissue	RD	8.4
Soft tissue	RH30	8
Soft tissue	RH41	9.3
Soft tissue	RKN	9.5
Soft tissue	S117	9.9
Soft tissue	SJRH30	8.8
Soft tissue	SKLMS1	9.3
Soft tissue	SKUT1	10.2
Soft tissue	TE125T	9
Soft tissue	TE159T	8.8
Soft tissue	TE441T	9.3
Soft tissue	TE617T	10.1
Stomach	2313287	8.8
Stomach	AGS	9.9
Stomach	AZ521	9.3
Stomach	ECC10	8.5
Stomach	ECC12	8.9
Stomach	FU97	9.2
Stomach	GCIY	9.2
Stomach	GSS	8.6
Stomach	GSU	8.4
Stomach	HGC27	9.9
Stomach	HS746T	10.8
Stomach	HUG1N	9.5
Stomach	IM95	9.6
Stomach	KATOIII	9.7
Stomach	KE39	8.9
Stomach	LMSU	9.3
Stomach	MKN1	9.7
Stomach	MKN45	10
Stomach	MKN74	9.6
Stomach	MKN7	9.3
Stomach	NCCSTCK140	9.3
Stomach	NCIN87	9
Stomach	NUGC2	8.3
Stomach	NUGC3	9.3
Stomach	NUGC4	8.7
Stomach	OCUM1	9.1
Stomach	RERFGC1B	9.3
Stomach	SH10TC	8.5
Stomach	SNU16	9.1
Stomach	SNU1	9.1
Stomach	SNU216	8.3
Stomach	SNU520	9.3
Stomach	SNU5	9.4
Stomach	SNU601	8.2
Stomach	SNU620	9.1
Stomach	SNU668	8
Stomach	SNU719	8.6
Stomach	TGBC11TKB	8.3
Thyroid	8305C	8.6
Thyroid	8505C	9.8
Thyroid	BCPAP	8.8
Thyroid	BHT101	7.6
Thyroid	CAL62	8.6
Thyroid	CGTHW1	9.4
Thyroid	FTC133	9.3
Thyroid	FTC238	9.1
Thyroid	ML1	9.1
Thyroid	SW579	9.4
Thyroid	TT2609C02	9.2
Thyroid	TT	8.4
Upper aerodigestive tract	BHY	7.9
Upper aerodigestive tract	BICR16	8.4
Upper aerodigestive tract	BICR18	8.7
Upper aerodigestive tract	BICR22	8.1
Upper aerodigestive tract	BICR31	8.2
Upper aerodigestive tract	BICR56	8.4
Upper aerodigestive tract	BICR6	7.8
Upper aerodigestive tract	CAL27	7.9
Upper aerodigestive tract	CAL33	8
Upper aerodigestive tract	DETROIT562	9.7
Upper aerodigestive tract	FADU	9
Upper aerodigestive tract	HS840T	9.8
Upper aerodigestive tract	HSC2	9
Upper aerodigestive tract	HSC3	10.3
Upper aerodigestive tract	HSC4	8
Upper aerodigestive tract	PECAPJ15	8.6
Upper aerodigestive tract	PECAPJ34CLONEC12	9.3
Upper aerodigestive tract	PECAPJ41CLONED2	8.1
Upper aerodigestive tract	PECAPJ49	9.4
Upper aerodigestive tract	SCC15	8
Upper aerodigestive tract	SCC25	9.3
Upper aerodigestive tract	SCC4	8.5
Upper aerodigestive tract	SCC9	7.9
Upper aerodigestive tract	SNU1076	6.5
Upper aerodigestive tract	SNU1214	9.2
Upper aerodigestive tract	SNU46	8.9
Upper aerodigestive tract	SNU899	7.6
Upper aerodigestive tract	YD10B	7.8
Upper aerodigestive tract	YD38	8.3
Upper aerodigestive tract	YD8	8.2
Urinary tract	5637	8.8
Urinary tract	639V	9.2
Urinary tract	647V	8.6
Urinary tract	BC3C	8.8
Urinary tract	BFTC905	8.5
Urinary tract	CAL29	8.7
Urinary tract	HS172T	8.6
Urinary tract	HT1197	9.7
Urinary tract	HT1376	9.3
Urinary tract	J82	9.7
Urinary tract	JMSU1	9.6
Urinary tract	KMBC2	10.1
Urinary tract	KU1919	9.3
Urinary tract	RT11284	8.5
Urinary tract	RT112	8.5
Urinary tract	RT4	9.5
Urinary tract	SCABER	9.1
Urinary tract	SW1710	7.5
Urinary tract	SW780	9
Urinary tract	T24	9.5
Urinary tract	TCCSUP	7.9
Urinary tract	UMUC1	7.7
Urinary tract	UMUC3	10.3
Urinary tract	VMCUB1	8.6

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	11.5
Adrenal gland	44.8
Appendix	10.7
Bone marrow	23.4
Breast	14.6
Cerebral cortex	16.5
Cervix, uterine	13.4
Colon	10.8
Duodenum	16.9
Endometrium	11.1
Epididymis	21
Esophagus	17.5
Fallopian tube	19.9
Gallbladder	20.4
Heart muscle	5.3
Kidney	15.1
Liver	7.8
Lung	14.9
Lymph node	11.9
Ovary	63.1
Pancreas	4.9
Parathyroid gland	15.3
Placenta	13.9
Prostate	15.5
Rectum	11.2
Salivary gland	5
Seminal vesicle	9.2
Skeletal muscle	7.6
Skin	9.6
Small intestine	23.7
Smooth muscle	10.2
Spleen	13.7
Stomach	10.1
Testis	50.7
Thyroid gland	19.9
Tonsil	10
Urinary bladder	13.7

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
25613071	Underexpression	Skin Basal Cell Carcinoma	It was detected that ING2 mRNA expression level decreased in tumoral tissues when compared to non-tumoral tissues from BCC patients (p=0.0001).
25190103	Underexpression	Osteosarcoma	In the present study, we confirmed that the levels of ING2 mRNA and protein were lower in cancer tissues than these levels in normal tissues. Loss of nuclear ING2 protein was significantly associated with a decreased survival time of patients.
24712846	Underexpression	Non-small Cell Lung Carcinoma; Adenocarcinoma; Squamous Cell Carcinoma	Decreased expression of ING2 gene and its clinicopathological significance in Chinese NSCLC patients. The IHC results showed that ING2 protein expression was significantly decreased in NSCLC samples compared with normal lung tissues (P
19962781	Loss of expression	Non-small Cell Lung Carcinoma	Expression of candidate tumor suppressor gene ING2 is lost in non-small cell lung carcinoma.
19437536	Overexpression	Colon Carcinoma	ING2 is upregulated in colon cancer and increases invasion by enhanced MMP13 expression.
19432890	Overexpression	Colon Carcinoma	Our recent results showed that ING2 is overexpressed in colorectal cancer, and induces colon cancer cell invasion through an MMP13-dependent pathway.
18160212	Underexpression	Hepatocellular Carcinoma	Decreased expression of ING2 gene and its clinicopathological significance in hepatocellular carcinoma. Using reverse transcription-polymerase chain reaction (RT-PCR) and Western blot, ING2 transcription and post-transcription level was found to be downregulated in the majority of tumors compared with matched non-tumors liver tissues (p=0.004 and p=0.014, respectively). The immunohistochemistry data indicated significant reduction of ING2 expression level in 44 of 84 (52.4%) HCC cases.
16755297	Underexpression	Cutaneous Melanoma	Nuclear ING2 expression is reduced in human cutaneous melanomas. Taken together, our results suggest that nuclear ING2 expression is significantly reduced in human melanomas and that reduced ING2 may be an important molecular event in the initiation of melanoma development.
16465410	Underexpression	Lung Carcinoma	ING1 expression was up-regulated in all 7 lung cancer cell lines that had a p53 mutation, while the expression of ING2 was down-regulated in 6 of 7 lung cancer cell lines that had a p53 mutation.
10072587	Overexpression	Breast Carcinoma	Both ING1 and ING1L are expressed in a variety of human tissues, but we found ING1L expression to be significantly more pronounced in tumors from several colon-cancer patients than in normal colon tissues excised at the same surgical sites.
26717876	altered expression	Breast Carcinoma; Cervical Carcinoma; Endometrial Carcinoma	Compared with that in the respective normal tissues, ING2 expression in breast cancer tissues was decreased, while that in cervical cancer was upregulated in the nuclei as well as the cytoplasm. In endometrial cancer, expression of ING2 was increased in the nuclei and declined in the cytoplasm compared with that in the normal endometrium.
27305909	Underexpression	Prostate Carcinoma	Inhibitor of growth 1 (ING1) and ING2 are tumor suppressors with reduced expression in many cancer types.

Summary
Symbol	ING2
Name	inhibitor of growth family member 2
Aliases	p33ING2; ING1L; inhibitor of growth family, member 1-like; ING1Lp; inhibitor of growth 1-like protein; Inhib ......
Location	4q35.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.51	4.27e-28	42.6	48.8	8.7	Loss
BRCA	Breast invasive carcinoma	1075	0.515	6.9e-74	32	58.2	9.8	Neutral
CESC	Cervical and endocervical cancers	292	0.593	4.24e-29	38	55.8	6.2	Loss
COAD	Colon adenocarcinoma	449	0.551	4.52e-37	35	61.9	3.1	Loss
ESCA	Esophageal carcinoma	183	0.611	4.12e-20	53	36.1	10.9	Loss
GBM	Glioblastoma multiforme	147	0.288	0.000396	17.7	78.2	4.1	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.513	6.75e-36	36.6	54.9	8.6	Loss
KIRC	Kidney renal clear cell carcinoma	525	0.263	9.68e-10	14.9	83	2.1	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.379	2.8e-11	9.7	87.2	3.1	Neutral
LAML	Acute Myeloid Leukemia	166	0.069	0.376	1.2	97.6	1.2	Neutral
LGG	Brain Lower Grade Glioma	513	0.427	3.96e-24	26.1	73.1	0.8	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.513	9.02e-26	46.2	50	3.8	Loss
LUAD	Lung adenocarcinoma	512	0.518	1.63e-36	36.5	54.7	8.8	Loss
LUSC	Lung squamous cell carcinoma	498	0.504	1.94e-33	66.7	28.1	5.2	Loss
OV	Ovarian serous cystadenocarcinoma	300	0.585	5.43e-29	71	21.3	7.7	Loss
PAAD	Pancreatic adenocarcinoma	177	0.549	2.43e-15	19.2	76.3	4.5	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.236	0.00251	8.6	88.9	2.5	Neutral
PRAD	Prostate adenocarcinoma	491	0.338	1.45e-14	6.1	90.6	3.3	Neutral
READ	Rectum adenocarcinoma	164	0.52	9.74e-13	43.3	51.8	4.9	Loss
SARC	Sarcoma	255	0.477	6.45e-16	36.9	51	12.2	Loss
SKCM	Skin Cutaneous Melanoma	367	0.502	8.45e-25	26.4	59.4	14.2	Neutral
STAD	Stomach adenocarcinoma	413	0.482	2.01e-25	46.2	50.4	3.4	Loss
TGCT	Testicular Germ Cell Tumors	150	0.265	0.00103	70	28	2	Loss
THCA	Thyroid carcinoma	497	0.185	3.44e-05	0.6	98.4	1	Neutral
THYM	Thymoma	119	0.233	0.0109	4.2	94.1	1.7	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.31	1.98e-13	22.5	74.7	2.8	Neutral

Summary
Symbol	ING2
Name	inhibitor of growth family member 2
Aliases	p33ING2; ING1L; inhibitor of growth family, member 1-like; ING1Lp; inhibitor of growth 1-like protein; Inhib ......
Location	4q35.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.188	9.76e-05	17	408	-0.003	0.279	NS/NA
BRCA	Breast invasive carcinoma	-0.15	8.89e-06	83	785	0.002	3.14e-07	NS/NA
CESC	Cervical and endocervical cancers	-0.208	0.000236	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.177	0.00162	19	297	-0.001	0.237	NS/NA
ESCA	Esophageal carcinoma	-0.178	0.0131	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.16	0.203	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.082	0.0558	20	522	0.006	1.79e-14	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.057	0.295	24	319	0.005	3.39e-06	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.05	0.391	23	275	0.002	0.137	NS/NA
LAML	Acute Myeloid Leukemia	-0.11	0.152	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.117	0.00726	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.123	0.012	41	373	0.002	0.0544	NS/NA
LUAD	Lung adenocarcinoma	-0.15	0.00102	21	456	-0.004	0.175	NS/NA
LUSC	Lung squamous cell carcinoma	-0.043	0.407	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.633	0.076	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.129	0.0808	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.174	0.0176	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.096	0.0269	35	498	-0.007	0.00176	NS/NA
READ	Rectum adenocarcinoma	-0.274	0.00564	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.174	0.00482	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.194	2.19e-05	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.144	0.00559	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.192	0.0164	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.103	0.0145	50	509	-0.002	0.877	NS/NA
THYM	Thymoma	-0.021	0.822	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.126	0.00653	34	431	0	0.599	NS/NA

Summary
Symbol	ING2
Name	inhibitor of growth family member 2
Aliases	p33ING2; ING1L; inhibitor of growth family, member 1-like; ING1Lp; inhibitor of growth 1-like protein; Inhib ......
Location	4q35.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	3	High
Appendix	1	Low
Bone marrow	1	Low
Breast	2	Medium
Bronchus	3	High
Caudate	2	Medium
Cerebellum	1	Low
Cerebral cortex	2	Medium
Cervix, uterine	3	High
Colon	2	Medium
Duodenum	2	Medium
Endometrium	2	Medium
Epididymis	2	Medium
Esophagus	2	Medium
Fallopian tube	2	Medium
Gallbladder	3	High
Heart muscle	2	Medium
Hippocampus	2	Medium
Kidney	2	Medium
Liver	2	Medium
Lung	2	Medium
Lymph node	2	Medium
Nasopharynx	3	High
Oral mucosa	2	Medium
Ovary	3	High
Pancreas	2	Medium
Parathyroid gland	3	High
Placenta	2	Medium
Prostate	2	Medium
Rectum	2	Medium
Salivary gland	2	Medium
Seminal vesicle	2	Medium
Skeletal muscle	1	Low
Skin	2	Medium
Small intestine	3	High
Smooth muscle	2	Medium
Soft tissue	2	Medium
Spleen	1	Low
Stomach	2	Medium
Testis	2	Medium
Thyroid gland	2	Medium
Tonsil	2	Medium
Urinary bladder	2	Medium
Vagina	2	Medium

Summary
Symbol	ING2
Name	inhibitor of growth family member 2
Aliases	p33ING2; ING1L; inhibitor of growth family, member 1-like; ING1Lp; inhibitor of growth 1-like protein; Inhib ......
Location	4q35.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.809	NS	24476821
BRCA	Breast invasive carcinoma	521	0.000279	Significant	23000897
COAD	Colon adenocarcinoma	149	0.00539	Significant	22810696
GBM	Glioblastoma multiforme	157	0.000672	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	3.89e-08	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.0925	NS	26536169
LGG	Brain Lower Grade Glioma	513	4.44e-08	Significant	26824661
LUAD	Lung adenocarcinoma	230	0.735	NS	25079552
LUSC	Lung squamous cell carcinoma	178	0.0317	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.0121	Significant	21720365
PRAD	Prostate adenocarcinoma	333	0.000625	Significant	26544944
READ	Rectum adenocarcinoma	67	0.868	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.718	NS	26091043
STAD	Stomach adenocarcinoma	277	4.18e-12	Significant	25079317
THCA	Thyroid carcinoma	391	0.0359	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.164	NS	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	1.327	0.197	NS
BRCA	Breast invasive carcinoma	1079	0.686	0.0837	NS
CESC	Cervical and endocervical cancers	291	0.83	0.573	NS
COAD	Colon adenocarcinoma	439	0.951	0.865	NS
ESCA	Esophageal carcinoma	184	0.654	0.209	NS
GBM	Glioblastoma multiforme	158	1.639	0.0554	NS
HNSC	Head and Neck squamous cell carcinoma	518	0.895	0.573	NS
KIRC	Kidney renal clear cell carcinoma	531	0.914	0.659	NS
KIRP	Kidney renal papillary cell carcinoma	287	0.375	0.0559	NS
LAML	Acute Myeloid Leukemia	149	0.864	0.619	NS
LGG	Brain Lower Grade Glioma	511	1.338	0.265	NS
LIHC	Liver hepatocellular carcinoma	365	1.327	0.246	NS
LUAD	Lung adenocarcinoma	502	1.52	0.0499	Shorter
LUSC	Lung squamous cell carcinoma	494	0.903	0.598	NS
OV	Ovarian serous cystadenocarcinoma	303	0.845	0.426	NS
PAAD	Pancreatic adenocarcinoma	177	1.013	0.966	NS
PCPG	Pheochromocytoma and Paraganglioma	179	0.438	0.488	NS
PRAD	Prostate adenocarcinoma	497	0.744	0.735	NS
READ	Rectum adenocarcinoma	159	1.409	0.547	NS
SARC	Sarcoma	259	0.745	0.342	NS
SKCM	Skin Cutaneous Melanoma	459	0.784	0.212	NS
STAD	Stomach adenocarcinoma	388	0.664	0.0625	NS
TGCT	Testicular Germ Cell Tumors	134	0.515	0.581	NS
THCA	Thyroid carcinoma	500	0.624	0.479	NS
THYM	Thymoma	119	1.515	0.647	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	0.826	0.558	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	0.011	0.833	NS
BRCA	Breast invasive carcinoma	1071	-0.033	0.277	NS
CESC	Cervical and endocervical cancers	167	-0.127	0.101	NS
COAD	Colon adenocarcinoma	445	-0.075	0.115	NS
ESCA	Esophageal carcinoma	162	-0.089	0.26	NS
HNSC	Head and Neck squamous cell carcinoma	448	0.059	0.21	NS
KIRC	Kidney renal clear cell carcinoma	531	-0.106	0.0145	Lower
KIRP	Kidney renal papillary cell carcinoma	260	-0.172	0.00535	Lower
LIHC	Liver hepatocellular carcinoma	347	0.044	0.416	NS
LUAD	Lung adenocarcinoma	507	0.061	0.171	NS
LUSC	Lung squamous cell carcinoma	497	0.086	0.0562	NS
OV	Ovarian serous cystadenocarcinoma	302	0.007	0.91	NS
PAAD	Pancreatic adenocarcinoma	176	-0.032	0.671	NS
READ	Rectum adenocarcinoma	156	0.005	0.955	NS
SKCM	Skin Cutaneous Melanoma	410	-0.043	0.387	NS
STAD	Stomach adenocarcinoma	392	0.003	0.956	NS
TGCT	Testicular Germ Cell Tumors	81	-0.043	0.703	NS
THCA	Thyroid carcinoma	499	-0.017	0.699	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.013	0.765	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	-0.169	0.00521	Lower
HNSC	Head and Neck squamous cell carcinoma	498	-0.048	0.28	NS
KIRC	Kidney renal clear cell carcinoma	525	-0.075	0.0858	NS
LGG	Brain Lower Grade Glioma	514	0.041	0.355	NS
LIHC	Liver hepatocellular carcinoma	366	-0.018	0.728	NS
OV	Ovarian serous cystadenocarcinoma	296	-0.045	0.436	NS
PAAD	Pancreatic adenocarcinoma	176	-0.127	0.0927	NS
STAD	Stomach adenocarcinoma	406	-0.049	0.322	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.259	1.21e-09	Higher

Summary
Symbol	ING2
Name	inhibitor of growth family member 2
Aliases	p33ING2; ING1L; inhibitor of growth family, member 1-like; ING1Lp; inhibitor of growth 1-like protein; Inhib ......
Location	4q35.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	ING2
Name	inhibitor of growth family member 2
Aliases	p33ING2; ING1L; inhibitor of growth family, member 1-like; ING1Lp; inhibitor of growth 1-like protein; Inhib ......
Location	4q35.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for ING2.

Summary
Symbol	ING2
Name	inhibitor of growth family member 2
Aliases	p33ING2; ING1L; inhibitor of growth family, member 1-like; ING1Lp; inhibitor of growth 1-like protein; Inhib ......
Location	4q35.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
19437536	Colon Carcinoma	downstream	MMP13	Positive regulation	Subsequent microarray analyses revealed that ING2 upregulates expression of matrix metalloproteinase 13 (MMP13), which enhances cancer invasion and metastasis.
27305909	Prostate Carcinoma	partner	ING1	Compensation	ING2 levels are increased upon downregulation of ING1 expression indicating a compensatory mechanism and suggests a novel crosstalk between ING1 and ING2 tumor suppressors to inhibit AR signaling and induce cellular senescence in PCa cells.
27305909	Prostate Carcinoma	downstream	AR; p16 (INK4a)	Negative regulation; Positive regulation	Accordingly, the data suggest that ING2 interacts with AR and hampers the AR transcriptional activation, causes growth arrest, and induces cellular senescence. The data further suggest that ING2 upregulates p16 (INK4a) , which is a novel target for ING2.