CR2Cancer

Summary
Symbol	JADE3
Name	jade family PHD finger 3
Aliases	KIAA0215; JADE-3; PHF16; PHD finger protein 16; jade family PHD finger protein 3; Protein Jade-3
Location	Xp11.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

[ TOP ]

Domain

PF10513 Enhancer of polycomb-like

Function

Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo.

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification write	Histone acetylation	H3, H4	H3ac, H4ac	14612400

> Gene Ontology [ TOP ]
Biological Process	GO:0006473 protein acetylation GO:0006475 internal protein amino acid acetylation GO:0016570 histone modification GO:0016573 histone acetylation GO:0018205 peptidyl-lysine modification GO:0018393 internal peptidyl-lysine acetylation GO:0018394 peptidyl-lysine acetylation GO:0043543 protein acylation GO:0043966 histone H3 acetylation GO:0043967 histone H4 acetylation GO:0043981 histone H4-K5 acetylation GO:0043982 histone H4-K8 acetylation GO:0043983 histone H4-K12 acetylation
Molecular Function	-
Cellular Component	GO:0000123 histone acetyltransferase complex GO:0031248 protein acetyltransferase complex GO:1902493 acetyltransferase complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-3214847: HATs acetylate histones

Summary
Symbol	JADE3
Name	jade family PHD finger 3
Aliases	KIAA0215; JADE-3; PHF16; PHD finger protein 16; jade family PHD finger protein 3; Protein Jade-3
Location	Xp11.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM757217	c.1706G>T	p.S569I	Substitution - Missense	Lung
COSM1714907	c.229G>A	p.E77K	Substitution - Missense	Skin
COSM488388	c.1966A>C	p.K656Q	Substitution - Missense	Kidney
COSM163441	c.862A>G	p.I288V	Substitution - Missense	Breast
COSM1121697	c.1343C>A	p.P448H	Substitution - Missense	Endometrium
COSM4946472	c.1600T>C	p.Y534H	Substitution - Missense	Liver
COSM757221	c.783A>T	p.K261N	Substitution - Missense	Lung
COSM3844755	c.1715C>G	p.S572C	Substitution - Missense	Breast
COSM1121700	c.2104G>A	p.G702S	Substitution - Missense	Endometrium
COSM1121698	c.1811G>A	p.R604H	Substitution - Missense	Large_intestine
COSM1121693	c.956C>T	p.T319M	Substitution - Missense	Stomach
COSM219574	c.2094G>T	p.L698F	Substitution - Missense	Breast
COSM1756581	c.1255G>A	p.E419K	Substitution - Missense	Urinary_tract
COSM488386	c.579A>C	p.L193L	Substitution - coding silent	Kidney
COSM1682573	c.1435C>A	p.L479M	Substitution - Missense	Large_intestine
COSM4408295	c.2092T>G	p.L698V	Substitution - Missense	Pancreas
COSM3765012	c.1474C>T	p.R492*	Substitution - Nonsense	Central_nervous_system
COSM5757546	c.650T>C	p.M217T	Substitution - Missense	Large_intestine
COSM673747	c.47-9C>G	p.?	Unknown	Endometrium
COSM4840336	c.2317C>T	p.L773L	Substitution - coding silent	Cervix
COSM3561787	c.2370G>A	p.R790R	Substitution - coding silent	Skin
COSM1756582	c.2408C>G	p.S803C	Substitution - Missense	Urinary_tract
COSM1663472	c.16C>T	p.P6S	Substitution - Missense	Kidney
COSM5761337	c.432C>T	p.D144D	Substitution - coding silent	Pancreas
COSM1121691	c.657C>A	p.F219L	Substitution - Missense	Endometrium
COSM5347588	c.1290_1293delCTAT	p.Y431fs*5	Deletion - Frameshift	Liver
COSM5094956	c.1653A>T	p.E551D	Substitution - Missense	Thymus
COSM1625908	c.1126G>A	p.E376K	Substitution - Missense	Liver
COSM1636552	c.2348A>C	p.N783T	Substitution - Missense	Liver
COSM1121698	c.1811G>A	p.R604H	Substitution - Missense	Endometrium
COSM3973672	c.361A>G	p.T121A	Substitution - Missense	Central_nervous_system
COSM5064698	c.1890C>T	p.C630C	Substitution - coding silent	Stomach
COSM1315528	c.403G>C	p.V135L	Substitution - Missense	Urinary_tract
COSM3561785	c.1549G>A	p.E517K	Substitution - Missense	Skin
COSM1121686	c.43G>A	p.E15K	Substitution - Missense	Stomach
COSM5412704	c.849C>T	p.I283I	Substitution - coding silent	Skin
COSM3914010	c.1226C>T	p.S409F	Substitution - Missense	Skin
COSM1121694	c.1063G>A	p.E355K	Substitution - Missense	Endometrium
COSM1121689	c.223G>A	p.E75K	Substitution - Missense	Endometrium
COSM3844753	c.912A>C	p.P304P	Substitution - coding silent	Breast
COSM4629020	c.1146T>C	p.A382A	Substitution - coding silent	Large_intestine
COSM3406387	c.310G>A	p.V104I	Substitution - Missense	Central_nervous_system
COSM5159319	c.973-10C>A	p.?	Unknown	Large_intestine
COSM757219	c.997G>T	p.A333S	Substitution - Missense	Lung
COSM1262040	c.656T>C	p.F219S	Substitution - Missense	Stomach
COSM5366825	c.1652A>C	p.E551A	Substitution - Missense	Large_intestine
COSM4149056	c.1137C>A	p.H379Q	Substitution - Missense	Ovary
COSM1262039	c.1267C>T	p.P423S	Substitution - Missense	Oesophagus
COSM5086493	c.92_93insA	p.I33fs*4	Insertion - Frameshift	Large_intestine
COSM4795767	c.1579G>A	p.A527T	Substitution - Missense	Liver
COSM4713950	c.1022A>C	p.E341A	Substitution - Missense	Large_intestine
COSM4589429	c.2076T>C	p.P692P	Substitution - coding silent	Bone
COSM3844751	c.313C>G	p.L105V	Substitution - Missense	Breast
COSM5423274	c.2375A>G	p.D792G	Substitution - Missense	Prostate
COSM1682573	c.1435C>A	p.L479M	Substitution - Missense	Large_intestine
COSM4406115	c.94A>C	p.K32Q	Substitution - Missense	Skin
COSM4649415	c.2450C>T	p.S817F	Substitution - Missense	Large_intestine
COSM4919167	c.6A>G	p.K2K	Substitution - coding silent	Liver
COSM1293014	c.1559C>T	p.A520V	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM356543	c.1809C>A	p.N603K	Substitution - Missense	Lung
COSM1194357	c.1780C>G	p.P594A	Substitution - Missense	Lung
COSM3800613	c.1360G>A	p.E454K	Substitution - Missense	Urinary_tract
COSM4473603	c.1861C>T	p.P621S	Substitution - Missense	Skin
COSM1315530	c.1384G>T	p.E462*	Substitution - Nonsense	Urinary_tract
COSM457539	c.660T>C	p.C220C	Substitution - coding silent	Breast
COSM3940002	c.1836T>G	p.S612S	Substitution - coding silent	Oesophagus
COSM5718270	c.869G>A	p.C290Y	Substitution - Missense	Skin
COSM1121687	c.121G>T	p.A41S	Substitution - Missense	Endometrium
COSM4713951	c.1561G>A	p.G521R	Substitution - Missense	Large_intestine
COSM3561783	c.1194G>A	p.Q398Q	Substitution - coding silent	Oesophagus
COSM5519866	c.529C>T	p.R177C	Substitution - Missense	Biliary_tract
COSM3561783	c.1194G>A	p.Q398Q	Substitution - coding silent	Skin
COSM4002303	c.246A>C	p.V82V	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM757218	c.1574C>A	p.T525K	Substitution - Missense	Lung
COSM4109602	c.2468G>T	p.R823M	Substitution - Missense	Stomach
COSM4156853	c.472A>C	p.M158L	Substitution - Missense	Thyroid
COSM3561782	c.552C>T	p.N184N	Substitution - coding silent	Skin
COSM1121692	c.925G>T	p.A309S	Substitution - Missense	Endometrium
COSM1121696	c.1234C>T	p.R412*	Substitution - Nonsense	Endometrium
COSM4002303	c.246A>C	p.V82V	Substitution - coding silent	Stomach
COSM1121692	c.925G>T	p.A309S	Substitution - Missense	Endometrium
COSM4951388	c.2068C>T	p.Q690*	Substitution - Nonsense	Liver
COSM4149057	c.1138C>A	p.H380N	Substitution - Missense	Ovary
COSM1497267	c.1233A>G	p.V411V	Substitution - coding silent	Kidney
COSM1644036	c.1294_1295insA	p.N432fs*10	Insertion - Frameshift	Stomach
COSM5757546	c.650T>C	p.M217T	Substitution - Missense	Large_intestine
COSM5898682	c.285G>A	p.R95R	Substitution - coding silent	Skin
COSM1121701	c.2228A>C	p.K743T	Substitution - Missense	Endometrium
COSM3561781	c.139G>A	p.D47N	Substitution - Missense	Skin
COSM4713949	c.323G>A	p.R108Q	Substitution - Missense	Large_intestine
COSM757216	c.2452C>A	p.H818N	Substitution - Missense	Lung
COSM1121688	c.158A>C	p.K53T	Substitution - Missense	Endometrium
COSM5892501	c.1342C>T	p.P448S	Substitution - Missense	Skin
COSM1682573	c.1435C>A	p.L479M	Substitution - Missense	Large_intestine
COSM3561784	c.1353G>A	p.E451E	Substitution - coding silent	Skin
COSM294698	c.2106C>A	p.G702G	Substitution - coding silent	Large_intestine
COSM5617558	c.1011C>A	p.T337T	Substitution - coding silent	Lung
COSM3844752	c.488T>G	p.V163G	Substitution - Missense	Breast
COSM488387	c.1612A>T	p.R538*	Substitution - Nonsense	Kidney
COSM1682573	c.1435C>A	p.L479M	Substitution - Missense	Large_intestine
COSM3844754	c.1479G>T	p.E493D	Substitution - Missense	Breast
COSM4951388	c.2068C>T	p.Q690*	Substitution - Nonsense	Liver
COSM1121699	c.2030T>C	p.V677A	Substitution - Missense	Endometrium
COSM1756581	c.1255G>A	p.E419K	Substitution - Missense	Urinary_tract
COSM125335	c.2021C>G	p.S674C	Substitution - Missense	Upper_aerodigestive_tract
COSM4109600	c.1375C>T	p.Q459*	Substitution - Nonsense	Stomach
COSM3414290	c.133C>T	p.R45W	Substitution - Missense	Oesophagus
COSM5742253	c.2061C>A	p.F687L	Substitution - Missense	Small_intestine
COSM257718	c.1613G>T	p.R538I	Substitution - Missense	Large_intestine
COSM4109601	c.1402C>T	p.R468*	Substitution - Nonsense	Stomach
COSM4713952	c.1718T>C	p.V573A	Substitution - Missense	Large_intestine
COSM4569266	c.1634T>A	p.M545K	Substitution - Missense	Skin
COSM4109599	c.322C>T	p.R108*	Substitution - Nonsense	Stomach
COSM125334	c.1775C>T	p.S592L	Substitution - Missense	Upper_aerodigestive_tract
COSM1121695	c.1158C>T	p.S386S	Substitution - coding silent	Endometrium
COSM125334	c.1775C>T	p.S592L	Substitution - Missense	Endometrium
COSM5412705	c.1515G>A	p.Q505Q	Substitution - coding silent	Skin
COSM1121686	c.43G>A	p.E15K	Substitution - Missense	Endometrium
COSM1468088	c.919C>T	p.R307W	Substitution - Missense	Large_intestine
COSM1728167	c.2131C>T	p.H711Y	Substitution - Missense	Liver
COSM4754375	c.2203A>C	p.K735Q	Substitution - Missense	Stomach
COSM1315529	c.1372G>C	p.V458L	Substitution - Missense	Urinary_tract
COSM1756582	c.2408C>G	p.S803C	Substitution - Missense	Urinary_tract
COSM5963978	c.2389G>A	p.E797K	Substitution - Missense	Breast
COSM1190533	c.1066G>A	p.V356M	Substitution - Missense	Lung
COSM1121693	c.956C>T	p.T319M	Substitution - Missense	Cervix
COSM1121694	c.1063G>A	p.E355K	Substitution - Missense	Pancreas
COSM1121686	c.43G>A	p.E15K	Substitution - Missense	Thyroid
COSM3783607	c.673G>A	p.V225I	Substitution - Missense	Stomach
COSM4850710	c.2296G>A	p.G766S	Substitution - Missense	Cervix
COSM1121690	c.535T>C	p.C179R	Substitution - Missense	Endometrium
COSM1490974	c.974G>A	p.C325Y	Substitution - Missense	Breast
COSM757220	c.822G>T	p.W274C	Substitution - Missense	Lung
COSM1220350	c.1271C>T	p.T424M	Substitution - Missense	Large_intestine
COSM1121693	c.956C>T	p.T319M	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5796587	c.394G>T	p.A132S	Substitution - Missense	Breast
COSM1468089	c.1100delA	p.N368fs*58	Deletion - Frameshift	Large_intestine
COSM163441	c.862A>G	p.I288V	Substitution - Missense	Breast
COSM1625908	c.1126G>A	p.E376K	Substitution - Missense	Liver
COSM3783607	c.673G>A	p.V225I	Substitution - Missense	Prostate
COSM1220349	c.620G>A	p.R207Q	Substitution - Missense	Large_intestine
COSM4713948	c.49C>A	p.P17T	Substitution - Missense	Large_intestine
COSM2965600	c.951G>A	p.L317L	Substitution - coding silent	Thyroid
COSM4379352	c.747G>T	p.L249L	Substitution - coding silent	Large_intestine
COSM1121693	c.956C>T	p.T319M	Substitution - Missense	Endometrium
COSM4471601	c.172C>G	p.H58D	Substitution - Missense	Skin
COSM4908749	c.601G>A	p.V201M	Substitution - Missense	Central_nervous_system
COSM1138153	c.619C>T	p.R207W	Substitution - Missense	Kidney
COSM3406388	c.2286G>C	p.Q762H	Substitution - Missense	Central_nervous_system
COSM3561786	c.1998C>T	p.S666S	Substitution - coding silent	Skin
COSM219574	c.2094G>T	p.L698F	Substitution - Missense	Breast
COSM5898683	c.1178C>T	p.T393I	Substitution - Missense	Skin
COSM4795767	c.1579G>A	p.A527T	Substitution - Missense	Liver
COSM3414291	c.2370G>T	p.R790S	Substitution - Missense	Oesophagus

> Text Mining based Variations [ TOP ]
There is no record for JADE3.

Summary
Symbol	JADE3
Name	jade family PHD finger 3
Aliases	KIAA0215; JADE-3; PHF16; PHD finger protein 16; jade family PHD finger protein 3; Protein Jade-3
Location	Xp11.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

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Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
Q92613	32	K	N6-acetyllysine	-	No	None detected
Q92613	85	S	Phosphoserine	-	No	None detected
Q92613	566	S	Phosphoserine	-	No	None detected
Q92613	601	K	N6-acetyllysine	-	No	None detected
Q92613	608	S	Phosphoserine	-	No	None detected
Q92613	638	K	N6-acetyllysine	-	No	None detected
Q92613	735	K	N6-acetyllysine	-	No	None detected
Q92613	774	S	Phosphoserine	-	No	None detected
Q92613	776	S	Phosphoserine	-	No	None detected
Q92613	780	S	Phosphoserine	-	No	None detected

Summary
Symbol	JADE3
Name	jade family PHD finger 3
Aliases	KIAA0215; JADE-3; PHF16; PHD finger protein 16; jade family PHD finger protein 3; Protein Jade-3
Location	Xp11.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	3.652	3.928	0.233	0.257	NS
BRCA	Breast invasive carcinoma	112	1100	4.325	5.031	0.646	6.8e-13	Over
CESC	Cervical and endocervical cancers	3	306	4.399	3.822	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	3.182	4.405	1.304	1.25e-26	Over
ESCA	Esophageal carcinoma	11	185	4.255	4.144	-0.108	0.71	NS
GBM	Glioblastoma multiforme	5	166	2.524	3.627	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	3.128	3.346	0.236	0.0365	NS
KIRC	Kidney renal clear cell carcinoma	72	534	4.167	3.949	-0.282	3.7e-05	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	3.778	3.675	-0.082	0.566	NS
LAML	Acute Myeloid Leukemia	0	173	NA	4.541	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	4.764	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	3.782	3.748	0.018	0.869	NS
LUAD	Lung adenocarcinoma	59	517	3.831	4.054	0.262	0.00206	NS
LUSC	Lung squamous cell carcinoma	51	501	3.749	3.836	0.162	0.0653	NS
OV	Ovarian serous cystadenocarcinoma	0	307	NA	4.489	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	3.588	3.438	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	5.514	3.218	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	3.929	3.873	-0.224	0.00505	NS
READ	Rectum adenocarcinoma	10	167	3.264	4.563	1.254	3.64e-07	Over
SARC	Sarcoma	2	263	3.587	3.665	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	3.092	3.725	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	3.217	4.164	0.834	5.53e-13	Over
TGCT	Testicular Germ Cell Tumors	0	156	NA	3.558	NA	NA	NA
THCA	Thyroid carcinoma	59	509	3.469	3.99	0.536	8.16e-18	NS
THYM	Thymoma	2	120	3.804	3.546	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	4.221	4.125	-0.161	0.247	NS

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	3.2
Adrenal gland	13.5
Appendix	4.3
Bone marrow	1.3
Breast	7.9
Cerebral cortex	6.3
Cervix, uterine	8.4
Colon	2.8
Duodenum	2.3
Endometrium	9.9
Epididymis	19.1
Esophagus	3.7
Fallopian tube	6.4
Gallbladder	5.1
Heart muscle	2.1
Kidney	4
Liver	3.9
Lung	5.5
Lymph node	5.7
Ovary	8.7
Pancreas	1.7
Parathyroid gland	5
Placenta	21.9
Prostate	6.9
Rectum	3.8
Salivary gland	1.5
Seminal vesicle	10
Skeletal muscle	0.4
Skin	3.6
Small intestine	2.7
Smooth muscle	7.5
Spleen	5.6
Stomach	3
Testis	22.5
Thyroid gland	6.9
Tonsil	5.7
Urinary bladder	4.5

> Text Mining based Expression [ TOP ]
There is no record.

Summary
Symbol	JADE3
Name	jade family PHD finger 3
Aliases	KIAA0215; JADE-3; PHF16; PHD finger protein 16; jade family PHD finger protein 3; Protein Jade-3
Location	Xp11.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.214	1.48e-05	20.3	62.4	17.3	Neutral
BRCA	Breast invasive carcinoma	1075	0.075	0.0138	17.1	66.3	16.6	Neutral
CESC	Cervical and endocervical cancers	292	0.202	0.000518	23.6	63	13.4	Neutral
COAD	Colon adenocarcinoma	449	0.157	0.000874	15.1	69	15.8	Neutral
ESCA	Esophageal carcinoma	183	0.44	4.46e-10	36.6	50.8	12.6	Loss
GBM	Glioblastoma multiforme	147	-0.056	0.5	24.5	72.8	2.7	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.365	1.35e-17	28.4	63.2	8.4	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.174	5.84e-05	9	85.1	5.9	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	-0.211	0.000303	11.5	55.9	32.6	Neutral
LAML	Acute Myeloid Leukemia	166	0.035	0.655	3	95.8	1.2	Neutral
LGG	Brain Lower Grade Glioma	513	0.094	0.034	19.3	75.6	5.1	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.011	0.841	27.2	61	11.8	Neutral
LUAD	Lung adenocarcinoma	512	0.442	7.69e-26	20.9	66.6	12.5	Neutral
LUSC	Lung squamous cell carcinoma	498	0.189	2.19e-05	27.5	59	13.5	Neutral
OV	Ovarian serous cystadenocarcinoma	300	0.433	3.98e-15	47	29	24	Loss
PAAD	Pancreatic adenocarcinoma	177	0.128	0.0885	14.7	80.2	5.1	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.056	0.481	27.8	67.9	4.3	Neutral
PRAD	Prostate adenocarcinoma	491	0.132	0.00349	5.7	90.8	3.5	Neutral
READ	Rectum adenocarcinoma	164	0.277	0.000329	19.5	63.4	17.1	Neutral
SARC	Sarcoma	255	0.032	0.609	20	43.9	36.1	Gain
SKCM	Skin Cutaneous Melanoma	367	-0.063	0.229	23.4	61.9	14.7	Neutral
STAD	Stomach adenocarcinoma	413	0.247	3.82e-07	15.5	71.2	13.3	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.105	0.201	18.7	63.3	18	Neutral
THCA	Thyroid carcinoma	497	-0.069	0.127	0.8	97.6	1.6	Neutral
THYM	Thymoma	119	0.201	0.0286	6.7	91.6	1.7	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.25	4.02e-09	11.4	71.9	16.8	Neutral

Summary
Symbol	JADE3
Name	jade family PHD finger 3
Aliases	KIAA0215; JADE-3; PHF16; PHD finger protein 16; jade family PHD finger protein 3; Protein Jade-3
Location	Xp11.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.329	4.97e-12	17	408	-0.106	0.0103	NS/NA
BRCA	Breast invasive carcinoma	-0.205	1.11e-09	83	785	-0.083	8.67e-12	NS/NA
CESC	Cervical and endocervical cancers	-0.288	2.82e-07	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.303	4.7e-08	19	297	0.038	0.729	NS/NA
ESCA	Esophageal carcinoma	-0.364	2.28e-07	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.128	0.309	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.234	3.9e-08	20	522	-0.011	0.397	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.058	0.283	24	319	0.076	0.0523	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.262	5.02e-06	23	275	0.006	0.115	NS/NA
LAML	Acute Myeloid Leukemia	-0.167	0.0299	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.078	0.0732	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.162	0.000976	41	373	-0.003	0.376	NS/NA
LUAD	Lung adenocarcinoma	-0.169	0.000208	21	456	0.15	0.259	NS/NA
LUSC	Lung squamous cell carcinoma	-0.248	1.1e-06	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.583	0.108	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.108	0.145	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.047	0.524	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.161	0.000186	35	498	-0.018	0.0122	NS/NA
READ	Rectum adenocarcinoma	-0.349	0.000373	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.072	0.243	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.226	7.76e-07	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.234	5.53e-06	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.263	0.000964	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.081	0.056	50	509	-0.117	0.304	NS/NA
THYM	Thymoma	-0.051	0.577	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.185	6.43e-05	34	431	-0.036	1.53e-07	NS/NA

Summary
Symbol	JADE3
Name	jade family PHD finger 3
Aliases	KIAA0215; JADE-3; PHF16; PHD finger protein 16; jade family PHD finger protein 3; Protein Jade-3
Location	Xp11.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA) [ TOP ]
There is no antibody staining data.

Summary
Symbol	JADE3
Name	jade family PHD finger 3
Aliases	KIAA0215; JADE-3; PHF16; PHD finger protein 16; jade family PHD finger protein 3; Protein Jade-3
Location	Xp11.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.841	NS	24476821
BRCA	Breast invasive carcinoma	521	0.192	NS	23000897
COAD	Colon adenocarcinoma	149	2.99e-06	Significant	22810696
GBM	Glioblastoma multiforme	157	2.75e-10	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	0.00112	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.0781	NS	26536169
LGG	Brain Lower Grade Glioma	513	1.08e-38	Significant	26824661
LUAD	Lung adenocarcinoma	230	6.04e-10	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	6.6e-10	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	4.33e-06	Significant	21720365
PRAD	Prostate adenocarcinoma	333	0.00201	Significant	26544944
READ	Rectum adenocarcinoma	67	0.00722	Significant	22810696
SKCM	Skin Cutaneous Melanoma	315	0.364	NS	26091043
STAD	Stomach adenocarcinoma	277	0.000112	Significant	25079317
THCA	Thyroid carcinoma	391	1.26e-06	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.000253	Significant	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	0.898	0.61	NS
BRCA	Breast invasive carcinoma	1079	1.215	0.407	NS
CESC	Cervical and endocervical cancers	291	1.109	0.773	NS
COAD	Colon adenocarcinoma	439	0.985	0.96	NS
ESCA	Esophageal carcinoma	184	2.731	0.00309	Shorter
GBM	Glioblastoma multiforme	158	0.6	0.0443	Longer
HNSC	Head and Neck squamous cell carcinoma	518	0.744	0.134	NS
KIRC	Kidney renal clear cell carcinoma	531	0.593	0.0102	Longer
KIRP	Kidney renal papillary cell carcinoma	287	4.534	0.000907	Shorter
LAML	Acute Myeloid Leukemia	149	0.802	0.476	NS
LGG	Brain Lower Grade Glioma	511	0.386	3.42e-05	Longer
LIHC	Liver hepatocellular carcinoma	365	1.325	0.252	NS
LUAD	Lung adenocarcinoma	502	0.97	0.887	NS
LUSC	Lung squamous cell carcinoma	494	1.014	0.941	NS
OV	Ovarian serous cystadenocarcinoma	303	1.134	0.547	NS
PAAD	Pancreatic adenocarcinoma	177	2.077	0.0212	Shorter
PCPG	Pheochromocytoma and Paraganglioma	179	1.462	0.676	NS
PRAD	Prostate adenocarcinoma	497	0.932	0.935	NS
READ	Rectum adenocarcinoma	159	1.171	0.811	NS
SARC	Sarcoma	259	1.451	0.231	NS
SKCM	Skin Cutaneous Melanoma	459	1.378	0.104	NS
STAD	Stomach adenocarcinoma	388	1.034	0.88	NS
TGCT	Testicular Germ Cell Tumors	134	543675702.092	0.34	NS
THCA	Thyroid carcinoma	500	0.542	0.337	NS
THYM	Thymoma	119	0.215	0.17	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	1.889	0.0493	Shorter

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	0.064	0.202	NS
BRCA	Breast invasive carcinoma	1071	-0.027	0.385	NS
CESC	Cervical and endocervical cancers	167	0.016	0.833	NS
COAD	Colon adenocarcinoma	445	0.037	0.435	NS
ESCA	Esophageal carcinoma	162	0.034	0.669	NS
HNSC	Head and Neck squamous cell carcinoma	448	-0.003	0.947	NS
KIRC	Kidney renal clear cell carcinoma	531	-0.148	0.000644	Lower
KIRP	Kidney renal papillary cell carcinoma	260	0.248	5.29e-05	Higher
LIHC	Liver hepatocellular carcinoma	347	-0.02	0.707	NS
LUAD	Lung adenocarcinoma	507	0.016	0.716	NS
LUSC	Lung squamous cell carcinoma	497	0.012	0.786	NS
OV	Ovarian serous cystadenocarcinoma	302	-0.084	0.146	NS
PAAD	Pancreatic adenocarcinoma	176	0.031	0.686	NS
READ	Rectum adenocarcinoma	156	0.075	0.354	NS
SKCM	Skin Cutaneous Melanoma	410	-0.05	0.315	NS
STAD	Stomach adenocarcinoma	392	0.001	0.987	NS
TGCT	Testicular Germ Cell Tumors	81	0.248	0.0254	Higher
THCA	Thyroid carcinoma	499	0.008	0.851	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.115	0.00971	Higher

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	0.044	0.471	NS
HNSC	Head and Neck squamous cell carcinoma	498	0.083	0.0649	NS
KIRC	Kidney renal clear cell carcinoma	525	-0.148	0.000655	Lower
LGG	Brain Lower Grade Glioma	514	-0.207	2.1e-06	Lower
LIHC	Liver hepatocellular carcinoma	366	0.082	0.118	NS
OV	Ovarian serous cystadenocarcinoma	296	0.086	0.139	NS
PAAD	Pancreatic adenocarcinoma	176	-0.003	0.966	NS
STAD	Stomach adenocarcinoma	406	-0.071	0.152	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.291	7.16e-12	Higher

Summary
Symbol	JADE3
Name	jade family PHD finger 3
Aliases	KIAA0215; JADE-3; PHF16; PHD finger protein 16; jade family PHD finger protein 3; Protein Jade-3
Location	Xp11.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	JADE3
Name	jade family PHD finger 3
Aliases	KIAA0215; JADE-3; PHF16; PHD finger protein 16; jade family PHD finger protein 3; Protein Jade-3
Location	Xp11.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for JADE3.

Summary
Symbol	JADE3
Name	jade family PHD finger 3
Aliases	KIAA0215; JADE-3; PHF16; PHD finger protein 16; jade family PHD finger protein 3; Protein Jade-3
Location	Xp11.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]
There is no record for JADE3.

> Interactions from Text Mining [ TOP ]
There is no record for JADE3.