CR2Cancer

Summary
Symbol	KDM1A
Name	lysine demethylase 1A
Aliases	KIAA0601; BHC110; LSD1; AOF2; KDM1; amine oxidase (flavin containing) domain 2; lysine (K)-specific demethyl ......
Location	1p36.12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

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Domain

PF01593 Flavin containing amine oxidoreductase
PF04433 SWIRM domain

Function

Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. Also acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in ANDR-containing complexes, which mediates phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag that prevents demethylation H3K4me, prevents H3K4me demethylase activity of KDM1A. Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation. Demethylates and stabilizes the DNA methylase DNMT1. Required for gastrulation during embryogenesis. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Effector of SNAI1-mediated transcription repression of E-cadherin/CDH1, CDN7 and KRT8. Required for the maintenance of the silenced state of the SNAI1 target genes E-cadherin/CDH1 and CDN7.

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification erase	Histone methylation	H3K4me1, H3K4me2, H3K9me	H3K4, H3K9	16223729

> Gene Ontology [ TOP ]
Biological Process	GO:0000018 regulation of DNA recombination GO:0000375 RNA splicing, via transesterification reactions GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile GO:0000380 alternative mRNA splicing, via spliceosome GO:0000398 mRNA splicing, via spliceosome GO:0000724 double-strand break repair via homologous recombination GO:0000725 recombinational repair GO:0001701 in utero embryonic development GO:0002262 myeloid cell homeostasis GO:0002521 leukocyte differentiation GO:0002573 myeloid leukocyte differentiation GO:0006144 purine nucleobase metabolic process GO:0006282 regulation of DNA repair GO:0006302 double-strand break repair GO:0006310 DNA recombination GO:0006397 mRNA processing GO:0006476 protein deacetylation GO:0006479 protein methylation GO:0006482 protein demethylation GO:0007596 blood coagulation GO:0007599 hemostasis GO:0008213 protein alkylation GO:0008214 protein dealkylation GO:0008361 regulation of cell size GO:0008380 RNA splicing GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage GO:0009112 nucleobase metabolic process GO:0009314 response to radiation GO:0009411 response to UV GO:0009416 response to light stimulus GO:0009636 response to toxic substance GO:0010212 response to ionizing radiation GO:0010332 response to gamma radiation GO:0010569 regulation of double-strand break repair via homologous recombination GO:0010720 positive regulation of cell development GO:0010725 regulation of primitive erythrocyte differentiation GO:0010817 regulation of hormone levels GO:0010975 regulation of neuron projection development GO:0010976 positive regulation of neuron projection development GO:0014074 response to purine-containing compound GO:0016570 histone modification GO:0016571 histone methylation GO:0016574 histone ubiquitination GO:0016575 histone deacetylation GO:0016577 histone demethylation GO:0018022 peptidyl-lysine methylation GO:0018205 peptidyl-lysine modification GO:0021536 diencephalon development GO:0021537 telencephalon development GO:0021543 pallium development GO:0021700 developmental maturation GO:0021983 pituitary gland development GO:0021987 cerebral cortex development GO:0030099 myeloid cell differentiation GO:0030218 erythrocyte differentiation GO:0030219 megakaryocyte differentiation GO:0030330 DNA damage response, signal transduction by p53 class mediator GO:0030851 granulocyte differentiation GO:0030900 forebrain development GO:0031056 regulation of histone modification GO:0031057 negative regulation of histone modification GO:0031058 positive regulation of histone modification GO:0031060 regulation of histone methylation GO:0031061 negative regulation of histone methylation GO:0031346 positive regulation of cell projection organization GO:0031396 regulation of protein ubiquitination GO:0031398 positive regulation of protein ubiquitination GO:0032091 negative regulation of protein binding GO:0032259 methylation GO:0032350 regulation of hormone metabolic process GO:0032352 positive regulation of hormone metabolic process GO:0032535 regulation of cellular component size GO:0032844 regulation of homeostatic process GO:0032846 positive regulation of homeostatic process GO:0033169 histone H3-K9 demethylation GO:0033182 regulation of histone ubiquitination GO:0033184 positive regulation of histone ubiquitination GO:0034101 erythrocyte homeostasis GO:0034644 cellular response to UV GO:0034720 histone H3-K4 demethylation GO:0034968 histone lysine methylation GO:0035162 embryonic hemopoiesis GO:0035270 endocrine system development GO:0035561 regulation of chromatin binding GO:0035563 positive regulation of chromatin binding GO:0035601 protein deacylation GO:0042445 hormone metabolic process GO:0042446 hormone biosynthetic process GO:0042551 neuron maturation GO:0042692 muscle cell differentiation GO:0042770 signal transduction in response to DNA damage GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0043392 negative regulation of DNA binding GO:0043393 regulation of protein binding GO:0043414 macromolecule methylation GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator GO:0045637 regulation of myeloid cell differentiation GO:0045639 positive regulation of myeloid cell differentiation GO:0045646 regulation of erythrocyte differentiation GO:0045648 positive regulation of erythrocyte differentiation GO:0045652 regulation of megakaryocyte differentiation GO:0045654 positive regulation of megakaryocyte differentiation GO:0045666 positive regulation of neuron differentiation GO:0045793 positive regulation of cell size GO:0045995 regulation of embryonic development GO:0046098 guanine metabolic process GO:0046683 response to organophosphorus GO:0046885 regulation of hormone biosynthetic process GO:0046886 positive regulation of hormone biosynthetic process GO:0048469 cell maturation GO:0048568 embryonic organ development GO:0048732 gland development GO:0048872 homeostasis of number of cells GO:0050769 positive regulation of neurogenesis GO:0050817 coagulation GO:0050878 regulation of body fluid levels GO:0051052 regulation of DNA metabolic process GO:0051090 regulation of sequence-specific DNA binding transcription factor activity GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051098 regulation of binding GO:0051099 positive regulation of binding GO:0051100 negative regulation of binding GO:0051101 regulation of DNA binding GO:0051567 histone H3-K9 methylation GO:0051568 histone H3-K4 methylation GO:0051569 regulation of histone H3-K4 methylation GO:0051570 regulation of histone H3-K9 methylation GO:0051572 negative regulation of histone H3-K4 methylation GO:0051573 negative regulation of histone H3-K9 methylation GO:0051591 response to cAMP GO:0051962 positive regulation of nervous system development GO:0055001 muscle cell development GO:0060215 primitive hemopoiesis GO:0060319 primitive erythrocyte differentiation GO:0060992 response to fungicide GO:0061351 neural precursor cell proliferation GO:0061647 histone H3-K9 modification GO:0070076 histone lysine demethylation GO:0070988 demethylation GO:0071214 cellular response to abiotic stimulus GO:0071320 cellular response to cAMP GO:0071407 cellular response to organic cyclic compound GO:0071417 cellular response to organonitrogen compound GO:0071478 cellular response to radiation GO:0071479 cellular response to ionizing radiation GO:0071480 cellular response to gamma radiation GO:0071482 cellular response to light stimulus GO:0072089 stem cell proliferation GO:0072091 regulation of stem cell proliferation GO:0072331 signal transduction by p53 class mediator GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator GO:0090066 regulation of anatomical structure size GO:0097193 intrinsic apoptotic signaling pathway GO:0098732 macromolecule deacylation GO:1901796 regulation of signal transduction by p53 class mediator GO:1901797 negative regulation of signal transduction by p53 class mediator GO:1902165 regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:1902229 regulation of intrinsic apoptotic signaling pathway in response to DNA damage GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage GO:1902253 regulation of intrinsic apoptotic signaling pathway by p53 class mediator GO:1902254 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator GO:1902275 regulation of chromatin organization GO:1902532 negative regulation of intracellular signal transduction GO:1903320 regulation of protein modification by small protein conjugation or removal GO:1903322 positive regulation of protein modification by small protein conjugation or removal GO:1903706 regulation of hemopoiesis GO:1903708 positive regulation of hemopoiesis GO:1905268 negative regulation of chromatin organization GO:1905269 positive regulation of chromatin organization GO:2000177 regulation of neural precursor cell proliferation GO:2000179 positive regulation of neural precursor cell proliferation GO:2000648 positive regulation of stem cell proliferation GO:2000779 regulation of double-strand break repair GO:2001020 regulation of response to DNA damage stimulus GO:2001021 negative regulation of response to DNA damage stimulus GO:2001233 regulation of apoptotic signaling pathway GO:2001234 negative regulation of apoptotic signaling pathway GO:2001242 regulation of intrinsic apoptotic signaling pathway GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
Molecular Function	GO:0001085 RNA polymerase II transcription factor binding GO:0002039 p53 binding GO:0003682 chromatin binding GO:0003713 transcription coactivator activity GO:0004407 histone deacetylase activity GO:0008134 transcription factor binding GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides GO:0019213 deacetylase activity GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity GO:0032451 demethylase activity GO:0032452 histone demethylase activity GO:0032453 histone demethylase activity (H3-K4 specific) GO:0032454 histone demethylase activity (H3-K9 specific) GO:0033558 protein deacetylase activity GO:0034648 histone demethylase activity (H3-dimethyl-K4 specific) GO:0035257 nuclear hormone receptor binding GO:0035258 steroid hormone receptor binding GO:0042162 telomeric DNA binding GO:0043425 bHLH transcription factor binding GO:0043426 MRF binding GO:0048037 cofactor binding GO:0050660 flavin adenine dinucleotide binding GO:0050662 coenzyme binding GO:0050681 androgen receptor binding GO:0051427 hormone receptor binding GO:0061752 telomeric repeat-containing RNA binding
Cellular Component	GO:0000781 chromosome, telomeric region GO:0000784 nuclear chromosome, telomeric region GO:0000785 chromatin GO:0000790 nuclear chromatin GO:0005667 transcription factor complex GO:0044454 nuclear chromosome part GO:0098687 chromosomal region GO:1990391 DNA repair complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-5625886: Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-983231: Factors involved in megakaryocyte development and platelet production R-HSA-3214815: HDACs deacetylate histones R-HSA-3214842: HDMs demethylate histones R-HSA-109582: Hemostasis R-HSA-195258: RHO GTPase Effectors R-HSA-5625740: RHO GTPases activate PKNs R-HSA-162582: Signal Transduction R-HSA-194315: Signaling by Rho GTPases

> KEGG and Reactome Pathway

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KEGG

Reactome

R-HSA-5625886: Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
R-HSA-3247509: Chromatin modifying enzymes
R-HSA-4839726: Chromatin organization
R-HSA-983231: Factors involved in megakaryocyte development and platelet production
R-HSA-3214815: HDACs deacetylate histones
R-HSA-3214842: HDMs demethylate histones
R-HSA-109582: Hemostasis
R-HSA-195258: RHO GTPase Effectors
R-HSA-5625740: RHO GTPases activate PKNs
R-HSA-162582: Signal Transduction
R-HSA-194315: Signaling by Rho GTPases

Summary
Symbol	KDM1A
Name	lysine demethylase 1A
Aliases	KIAA0601; BHC110; LSD1; AOF2; KDM1; amine oxidase (flavin containing) domain 2; lysine (K)-specific demethyl ......
Location	1p36.12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

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COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM4448598	c.1092delG	p.V365fs*5	Deletion - Frameshift	Skin
COSM1601923	c.21G>T	p.A7A	Substitution - coding silent	Liver
COSM1340246	c.1846C>T	p.Q616*	Substitution - Nonsense	Large_intestine
COSM3671670	c.2346G>T	p.R782R	Substitution - coding silent	Prostate
COSM75101	c.454C>A	p.P152T	Substitution - Missense	Ovary
COSM3376072	c.985G>A	p.A329T	Substitution - Missense	Pancreas
COSM5788990	c.215G>T	p.G72V	Substitution - Missense	Breast
COSM1667249	c.2513C>T	p.A838V	Substitution - Missense	Skin
COSM5417902	c.990+5G>T	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM905725	c.2584C>T	p.R862C	Substitution - Missense	Endometrium
COSM3789659	c.754G>A	p.E252K	Substitution - Missense	Urinary_tract
COSM4029649	c.676A>G	p.T226A	Substitution - Missense	Stomach
COSM4831043	c.817C>A	p.H273N	Substitution - Missense	Cervix
COSM5788990	c.215G>T	p.G72V	Substitution - Missense	Breast
COSM1255479	c.812G>T	p.R271L	Substitution - Missense	Stomach
COSM215525	c.1207G>A	p.E403K	Substitution - Missense	Central_nervous_system
COSM905706	c.847A>G	p.N283D	Substitution - Missense	Endometrium
COSM4633632	c.1931C>T	p.A644V	Substitution - Missense	Large_intestine
COSM5044361	c.1210C>T	p.Q404*	Substitution - Nonsense	Adrenal_gland
COSM1601930	c.1874A>C	p.E625A	Substitution - Missense	Liver
COSM905721	c.2409A>G	p.P803P	Substitution - coding silent	Endometrium
COSM1340251	c.2427G>A	p.S809S	Substitution - coding silent	Large_intestine
COSM5795881	c.954A>G	p.Q318Q	Substitution - coding silent	Breast
COSM905712	c.1501G>A	p.E501K	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM21700	c.577+5G>T	p.?	Unknown	Lung
COSM679031	c.1399G>T	p.E467*	Substitution - Nonsense	Lung
COSM215525	c.1207G>A	p.E403K	Substitution - Missense	Central_nervous_system
COSM3730593	c.1843C>T	p.R615*	Substitution - Nonsense	Stomach
COSM4598986	c.541G>C	p.D181H	Substitution - Missense	Upper_aerodigestive_tract
COSM4995405	c.254C>T	p.A85V	Substitution - Missense	Upper_aerodigestive_tract
COSM3804388	c.1189G>C	p.E397Q	Substitution - Missense	Breast
COSM5668642	c.1868G>T	p.G623V	Substitution - Missense	Soft_tissue
COSM128299	c.1176C>T	p.V392V	Substitution - coding silent	Upper_aerodigestive_tract
COSM905717	c.1926C>T	p.C642C	Substitution - coding silent	Central_nervous_system
COSM3729117	c.2135G>A	p.R712K	Substitution - Missense	Stomach
COSM5005593	c.2354A>C	p.Y785S	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4414708	c.1007G>A	p.R336Q	Substitution - Missense	Kidney
COSM905719	c.2106C>T	p.F702F	Substitution - coding silent	Endometrium
COSM1185366	c.35C>T	p.A12V	Substitution - Missense	Lung
COSM905723	c.2455C>T	p.R819*	Substitution - Nonsense	Stomach
COSM5053233	c.2577G>A	p.T859T	Substitution - coding silent	Stomach
COSM215525	c.1207G>A	p.E403K	Substitution - Missense	Central_nervous_system
COSM4610509	c.2516T>C	p.L839P	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4029667	c.943C>A	p.R315R	Substitution - coding silent	Stomach
COSM1296009	c.2410A>G	p.I804V	Substitution - Missense	Urinary_tract
COSM4793506	c.240C>T	p.S80S	Substitution - coding silent	Liver
COSM5626524	c.1321C>G	p.Q441E	Substitution - Missense	Oesophagus
COSM381706	c.1981G>A	p.V661I	Substitution - Missense	Lung
COSM1601930	c.1874A>C	p.E625A	Substitution - Missense	Liver
COSM4793506	c.240C>T	p.S80S	Substitution - coding silent	Liver
COSM4428781	c.104C>T	p.S35F	Substitution - Missense	Oesophagus
COSM1316122	c.1658T>C	p.L553P	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3864841	c.1021C>T	p.R341C	Substitution - Missense	Skin
COSM3485389	c.378C>T	p.S126S	Substitution - coding silent	Skin
COSM3804390	c.1995A>C	p.P665P	Substitution - coding silent	Breast
COSM3789659	c.754G>A	p.E252K	Substitution - Missense	Skin
COSM1579571	c.2537C>T	p.A846V	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1560187	c.1088C>A	p.A363D	Substitution - Missense	Large_intestine
COSM1296007	c.1266C>T	p.F422F	Substitution - coding silent	Urinary_tract
COSM4694850	c.2195C>T	p.A732V	Substitution - Missense	Large_intestine
COSM161878	c.775G>A	p.E259K	Substitution - Missense	Breast
COSM3804386	c.812G>A	p.R271Q	Substitution - Missense	Breast
COSM4995402	c.154C>T	p.P52S	Substitution - Missense	Upper_aerodigestive_tract
COSM4694859	c.2531G>A	p.R844Q	Substitution - Missense	Large_intestine
COSM5777502	c.2597C>A	p.P866Q	Substitution - Missense	Breast
COSM381706	c.1981G>A	p.V661I	Substitution - Missense	Large_intestine
COSM21700	c.577+5G>T	p.?	Unknown	Lung
COSM4029675	c.2008T>C	p.W670R	Substitution - Missense	Stomach
COSM905712	c.1501G>A	p.E501K	Substitution - Missense	Endometrium
COSM213759	c.1045C>G	p.L349V	Substitution - Missense	Breast
COSM1999575	c.422G>T	p.R141I	Substitution - Missense	Large_intestine
COSM3485391	c.456C>T	p.P152P	Substitution - coding silent	Skin
COSM679029	c.1522C>G	p.H508D	Substitution - Missense	Lung
COSM4029671	c.1641A>G	p.S547S	Substitution - coding silent	Stomach
COSM4029673	c.1896C>T	p.R632R	Substitution - coding silent	Stomach
COSM1317562	c.1995A>G	p.P665P	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM168257	c.852C>T	p.F284F	Substitution - coding silent	Endometrium
COSM905717	c.1926C>T	p.C642C	Substitution - coding silent	Oesophagus
COSM3485465	c.1936C>G	p.L646V	Substitution - Missense	Skin
COSM1560184	c.1272C>T	p.V424V	Substitution - coding silent	Large_intestine
COSM4832457	c.1635C>T	p.L545L	Substitution - coding silent	Cervix
COSM1999579	c.465C>T	p.P155P	Substitution - coding silent	Large_intestine
COSM3864839	c.979T>A	p.L327M	Substitution - Missense	Skin
COSM1340244	c.1251T>C	p.S417S	Substitution - coding silent	Large_intestine
COSM4406091	c.2449A>T	p.I817F	Substitution - Missense	Skin
COSM905717	c.1926C>T	p.C642C	Substitution - coding silent	Endometrium
COSM3700656	c.1932A>T	p.A644A	Substitution - coding silent	Liver
COSM4775584	c.1321C>T	p.Q441*	Substitution - Nonsense	Haematopoietic_and_lymphoid_tissue
COSM1999579	c.465C>T	p.P155P	Substitution - coding silent	Large_intestine
COSM1185364	c.34G>T	p.A12S	Substitution - Missense	Lung
COSM3418913	c.2233G>A	p.D745N	Substitution - Missense	Liver
COSM5380132	c.1292C>T	p.S431F	Substitution - Missense	Skin
COSM5969249	c.1338T>C	p.H446H	Substitution - coding silent	Upper_aerodigestive_tract
COSM4503035	c.629C>T	p.S210F	Substitution - Missense	Skin
COSM4694847	c.1735_1737delGAT	p.D581delD	Deletion - In frame	Large_intestine
COSM1296002	c.599A>G	p.Q200R	Substitution - Missense	Urinary_tract
COSM3984848	c.747G>A	p.L249L	Substitution - coding silent	Kidney
COSM1742098	c.982G>A	p.E328K	Substitution - Missense	Urinary_tract
COSM5549539	c.985G>T	p.A329S	Substitution - Missense	Prostate
COSM5777586	c.620G>A	p.R207Q	Substitution - Missense	Breast
COSM4617358	c.869T>C	p.I290T	Substitution - Missense	Large_intestine
COSM245191	c.2317T>G	p.S773A	Substitution - Missense	Prostate
COSM4791259	c.1193A>G	p.K398R	Substitution - Missense	Liver
COSM905710	c.1433A>G	p.K478R	Substitution - Missense	Endometrium
COSM5496794	c.2505G>C	p.V835V	Substitution - coding silent	Biliary_tract
COSM5447034	c.1655T>C	p.I552T	Substitution - Missense	Large_intestine
COSM4694856	c.2440C>A	p.P814T	Substitution - Missense	Large_intestine
COSM5673403	c.1623-2A>C	p.?	Unknown	Soft_tissue
COSM3418913	c.2233G>A	p.D745N	Substitution - Missense	Large_intestine
COSM5559904	c.2062T>G	p.L688V	Substitution - Missense	Prostate
COSM1999687	c.2326C>T	p.R776C	Substitution - Missense	Stomach
COSM4989124	c.1735G>C	p.D579H	Substitution - Missense	Soft_tissue
COSM3418911	c.944G>A	p.R315Q	Substitution - Missense	Large_intestine
COSM4791259	c.1193A>G	p.K398R	Substitution - Missense	Liver
COSM5811085	c.1691A>G	p.N564S	Substitution - Missense	Liver
COSM3418913	c.2233G>A	p.D745N	Substitution - Missense	Large_intestine
COSM905723	c.2455C>T	p.R819*	Substitution - Nonsense	Endometrium
COSM1316124	c.1665G>T	p.W555C	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3864841	c.1021C>T	p.R341C	Substitution - Missense	Skin
COSM905717	c.1926C>T	p.C642C	Substitution - coding silent	Large_intestine
COSM4029669	c.1563A>G	p.L521L	Substitution - coding silent	Stomach
COSM3804392	c.2426C>G	p.S809W	Substitution - Missense	Breast
COSM1296005	c.926C>G	p.S309*	Substitution - Nonsense	Urinary_tract
COSM4452679	c.2050A>T	p.N684Y	Substitution - Missense	Skin
COSM3485457	c.1597C>T	p.Q533*	Substitution - Nonsense	Skin
COSM5927159	c.412G>A	p.E138K	Substitution - Missense	Skin
COSM257213	c.515C>T	p.S172L	Substitution - Missense	Large_intestine
COSM1999579	c.465C>T	p.P155P	Substitution - coding silent	Large_intestine
COSM4694853	c.2202A>C	p.E734D	Substitution - Missense	Large_intestine

> Text Mining based Variations [ TOP ]
There is no record for KDM1A.

Summary
Symbol	KDM1A
Name	lysine demethylase 1A
Aliases	KIAA0601; BHC110; LSD1; AOF2; KDM1; amine oxidase (flavin containing) domain 2; lysine (K)-specific demethyl ......
Location	1p36.12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

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Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
O60341	104	T	Phosphothreonine	-	No	None detected
O60341	126	S	Phosphoserine	-	No	None detected
O60341	131	S	Phosphoserine	-	No	None detected
O60341	135	Y	Phosphotyrosine	-	No	None detected
O60341	137	S	Phosphoserine	-	No	None detected
O60341	166	S	Phosphoserine	-	No	None detected
O60341	611	S	Phosphoserine	-	No	None detected
O60341	849	S	Phosphoserine	-	No	None detected

Summary
Symbol	KDM1A
Name	lysine demethylase 1A
Aliases	KIAA0601; BHC110; LSD1; AOF2; KDM1; amine oxidase (flavin containing) domain 2; lysine (K)-specific demethyl ......
Location	1p36.12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

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Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	6.305	7.266	0.84	1.6e-07	Over
BRCA	Breast invasive carcinoma	112	1100	6.217	6.638	0.452	2.77e-20	NS
CESC	Cervical and endocervical cancers	3	306	6.453	6.884	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	6.13	6.89	0.778	2.53e-22	Over
ESCA	Esophageal carcinoma	11	185	5.786	6.561	0.683	0.00119	Over
GBM	Glioblastoma multiforme	5	166	6.17	6.623	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	6.206	6.716	0.559	1.34e-13	NS
KIRC	Kidney renal clear cell carcinoma	72	534	6.095	5.592	-0.48	3.11e-29	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	5.938	5.941	-0.034	0.674	NS
LAML	Acute Myeloid Leukemia	0	173	NA	6.758	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	6.482	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	4.697	4.919	0.271	0.000731	NS
LUAD	Lung adenocarcinoma	59	517	5.74	6.299	0.628	3.46e-19	Over
LUSC	Lung squamous cell carcinoma	51	501	5.754	6.635	0.979	8.51e-34	Over
OV	Ovarian serous cystadenocarcinoma	0	307	NA	6.911	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	6	6.146	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	6.092	5.535	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	6.461	6.757	0.334	1.91e-09	NS
READ	Rectum adenocarcinoma	10	167	6.113	6.927	0.722	0.000113	Over
SARC	Sarcoma	2	263	5.965	6.313	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	8.423	6.535	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	5.8	6.25	0.479	2.16e-06	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	7.584	NA	NA	NA
THCA	Thyroid carcinoma	59	509	6.081	6.218	0.154	6.38e-07	NS
THYM	Thymoma	2	120	6.729	7.08	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	6.422	7.182	0.742	2.39e-15	Over

> Cancer Cell Line Encyclopedia (CCLE)

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Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	9.9
Autonomic ganglia	CHP212	8.8
Autonomic ganglia	IMR32	9.9
Autonomic ganglia	KELLY	10.3
Autonomic ganglia	KPNRTBM1	9.7
Autonomic ganglia	KPNSI9S	8.6
Autonomic ganglia	KPNYN	9.5
Autonomic ganglia	MHHNB11	10.2
Autonomic ganglia	NB1	10.3
Autonomic ganglia	NH6	9
Autonomic ganglia	SHSY5Y	10.7
Autonomic ganglia	SIMA	9.9
Autonomic ganglia	SKNAS	9.8
Autonomic ganglia	SKNBE2	10
Autonomic ganglia	SKNDZ	10.5
Autonomic ganglia	SKNFI	9.4
Autonomic ganglia	SKNSH	9.5
Biliary tract	HUCCT1	9
Biliary tract	HUH28	8.2
Biliary tract	SNU1079	8.8
Biliary tract	SNU1196	9
Biliary tract	SNU245	9
Biliary tract	SNU308	8.8
Biliary tract	SNU478	9.9
Bone	143B	9.6
Bone	A673	10
Bone	CADOES1	9.7
Bone	CAL78	9.9
Bone	G292CLONEA141B1	9.6
Bone	HOS	9.7
Bone	HS706T	8.6
Bone	HS737T	8.3
Bone	HS819T	8
Bone	HS821T	8.7
Bone	HS822T	8
Bone	HS863T	8.3
Bone	HS870T	8
Bone	HS888T	8.7
Bone	MG63	9.1
Bone	MHHES1	10.4
Bone	OUMS27	8.7
Bone	RDES	10.7
Bone	SJSA1	8.7
Bone	SKES1	10.7
Bone	SKNMC	10.2
Bone	SW1353	8.7
Bone	T173	7.7
Bone	TC71	10.2
Bone	U2OS	9.4
Breast	AU565	8.7
Breast	BT20	8.8
Breast	BT474	9.2
Breast	BT483	9
Breast	BT549	9.6
Breast	CAL120	9.1
Breast	CAL148	10.2
Breast	CAL51	9.9
Breast	CAL851	10.5
Breast	CAMA1	9.3
Breast	DU4475	9.2
Breast	EFM192A	7.9
Breast	EFM19	9.3
Breast	EVSAT	8.8
Breast	HCC1143	8.2
Breast	HCC1187	9.9
Breast	HCC1395	9.4
Breast	HCC1419	8.4
Breast	HCC1428	9.3
Breast	HCC1500	8.6
Breast	HCC1569	8.3
Breast	HCC1599	9.6
Breast	HCC1806	10.1
Breast	HCC1937	8.5
Breast	HCC1954	9.2
Breast	HCC202	8.7
Breast	HCC2157	10.1
Breast	HCC2218	8
Breast	HCC38	9
Breast	HCC70	9.4
Breast	HDQP1	10.2
Breast	HMC18	9.4
Breast	HS274T	8.1
Breast	HS281T	8.9
Breast	HS343T	8.6
Breast	HS578T	9
Breast	HS606T	8.2
Breast	HS739T	8.6
Breast	HS742T	8.2
Breast	JIMT1	9.2
Breast	KPL1	9.2
Breast	MCF7	8.7
Breast	MDAMB134VI	8.7
Breast	MDAMB157	9
Breast	MDAMB175VII	7.6
Breast	MDAMB231	8.9
Breast	MDAMB361	8.7
Breast	MDAMB415	8.1
Breast	MDAMB436	8.3
Breast	MDAMB453	9
Breast	MDAMB468	9.3
Breast	SKBR3	8.5
Breast	T47D	8.5
Breast	UACC812	8.2
Breast	UACC893	8.8
Breast	YMB1	8.1
Breast	ZR751	7.6
Breast	ZR7530	8.2
Central nervous system	1321N1	9.3
Central nervous system	42MGBA	8.7
Central nervous system	8MGBA	9.1
Central nervous system	A172	8.7
Central nervous system	AM38	9.3
Central nervous system	BECKER	8.8
Central nervous system	CAS1	8.8
Central nervous system	CCFSTTG1	8.8
Central nervous system	D283MED	10.2
Central nervous system	D341MED	10.1
Central nervous system	DAOY	9.7
Central nervous system	DBTRG05MG	9.3
Central nervous system	DKMG	8.5
Central nervous system	GAMG	8.5
Central nervous system	GB1	11
Central nervous system	GI1	8.7
Central nervous system	GMS10	8.5
Central nervous system	GOS3	7.9
Central nervous system	H4	8.9
Central nervous system	HS683	8.8
Central nervous system	KALS1	9.5
Central nervous system	KG1C	8.2
Central nervous system	KNS42	8.4
Central nervous system	KNS60	8.8
Central nervous system	KNS81	6.3
Central nervous system	KS1	8.3
Central nervous system	LN18	9.1
Central nervous system	LN229	8.9
Central nervous system	M059K	9
Central nervous system	MOGGCCM	8.8
Central nervous system	MOGGUVW	9.9
Central nervous system	NMCG1	8.3
Central nervous system	ONS76	8.9
Central nervous system	SF126	8.9
Central nervous system	SF295	8.7
Central nervous system	SNB19	8.5
Central nervous system	SNU1105	9.2
Central nervous system	SNU201	8.9
Central nervous system	SNU466	9
Central nervous system	SNU489	10
Central nervous system	SNU626	7
Central nervous system	SNU738	9.4
Central nervous system	SW1088	9.1
Central nervous system	SW1783	9
Central nervous system	T98G	8.9
Central nervous system	TM31	10
Central nervous system	U118MG	8.9
Central nervous system	U138MG	8.6
Central nervous system	U251MG	8.2
Central nervous system	U87MG	8.2
Central nervous system	YH13	9.2
Central nervous system	YKG1	8.7
Endometrium	AN3CA	10
Endometrium	COLO684	10.4
Endometrium	EFE184	8.5
Endometrium	EN	9.5
Endometrium	ESS1	8.6
Endometrium	HEC108	8.7
Endometrium	HEC151	9.1
Endometrium	HEC1A	8.8
Endometrium	HEC1B	9.3
Endometrium	HEC251	9.8
Endometrium	HEC265	9.2
Endometrium	HEC50B	8.8
Endometrium	HEC59	9.6
Endometrium	HEC6	9.8
Endometrium	ISHIKAWAHERAKLIO02ER	9.4
Endometrium	JHUEM1	9
Endometrium	JHUEM2	9.2
Endometrium	JHUEM3	9.2
Endometrium	KLE	10
Endometrium	MFE280	8.8
Endometrium	MFE296	10
Endometrium	MFE319	8.5
Endometrium	RL952	9.4
Endometrium	SNGM	9.3
Endometrium	SNU1077	8.9
Endometrium	SNU685	10
Endometrium	TEN	9
Haematopoietic and lymphoid	697	10.9
Haematopoietic and lymphoid	A3KAW	10.1
Haematopoietic and lymphoid	A4FUK	9
Haematopoietic and lymphoid	ALLSIL	10.5
Haematopoietic and lymphoid	AML193	8.4
Haematopoietic and lymphoid	AMO1	9.4
Haematopoietic and lymphoid	BCP1	8.9
Haematopoietic and lymphoid	BDCM	9
Haematopoietic and lymphoid	BL41	10.3
Haematopoietic and lymphoid	BL70	9.6
Haematopoietic and lymphoid	BV173	10.5
Haematopoietic and lymphoid	CA46	9.4
Haematopoietic and lymphoid	CI1	9.6
Haematopoietic and lymphoid	CMK115	10.1
Haematopoietic and lymphoid	CMK86	10.8
Haematopoietic and lymphoid	CMK	10.1
Haematopoietic and lymphoid	CMLT1	9.9
Haematopoietic and lymphoid	COLO775	9.5
Haematopoietic and lymphoid	DAUDI	8.5
Haematopoietic and lymphoid	DB	9.4
Haematopoietic and lymphoid	DEL	8.8
Haematopoietic and lymphoid	DND41	10.3
Haematopoietic and lymphoid	DOHH2	9.8
Haematopoietic and lymphoid	EB1	8.8
Haematopoietic and lymphoid	EB2	8.8
Haematopoietic and lymphoid	EHEB	9
Haematopoietic and lymphoid	EJM	9.2
Haematopoietic and lymphoid	EM2	9.7
Haematopoietic and lymphoid	EOL1	9.8
Haematopoietic and lymphoid	F36P	9.9
Haematopoietic and lymphoid	GA10	9.5
Haematopoietic and lymphoid	GDM1	9.1
Haematopoietic and lymphoid	GRANTA519	8.2
Haematopoietic and lymphoid	HDLM2	9.5
Haematopoietic and lymphoid	HDMYZ	9.6
Haematopoietic and lymphoid	HEL9217	10.4
Haematopoietic and lymphoid	HEL	10
Haematopoietic and lymphoid	HH	10.1
Haematopoietic and lymphoid	HL60	8.5
Haematopoietic and lymphoid	HPBALL	10.6
Haematopoietic and lymphoid	HS604T	7.7
Haematopoietic and lymphoid	HS611T	8.7
Haematopoietic and lymphoid	HS616T	8.1
Haematopoietic and lymphoid	HS751T	7.9
Haematopoietic and lymphoid	HT	9.3
Haematopoietic and lymphoid	HTK	10.1
Haematopoietic and lymphoid	HUNS1	9.7
Haematopoietic and lymphoid	HUT102	8.4
Haematopoietic and lymphoid	HUT78	9.3
Haematopoietic and lymphoid	JEKO1	10.4
Haematopoietic and lymphoid	JK1	9.3
Haematopoietic and lymphoid	JM1	9.8
Haematopoietic and lymphoid	JURKAT	10.5
Haematopoietic and lymphoid	JURLMK1	8.7
Haematopoietic and lymphoid	JVM2	9
Haematopoietic and lymphoid	JVM3	8.6
Haematopoietic and lymphoid	K562	9.8
Haematopoietic and lymphoid	KARPAS299	9.1
Haematopoietic and lymphoid	KARPAS422	9.4
Haematopoietic and lymphoid	KARPAS620	9.3
Haematopoietic and lymphoid	KASUMI1	9.9
Haematopoietic and lymphoid	KASUMI2	10
Haematopoietic and lymphoid	KASUMI6	9.8
Haematopoietic and lymphoid	KCL22	9.9
Haematopoietic and lymphoid	KE37	10.4
Haematopoietic and lymphoid	KE97	9.6
Haematopoietic and lymphoid	KG1	9.7
Haematopoietic and lymphoid	KHM1B	8.9
Haematopoietic and lymphoid	KIJK	8.7
Haematopoietic and lymphoid	KMH2	9.6
Haematopoietic and lymphoid	KMM1	9.3
Haematopoietic and lymphoid	KMS11	9.3
Haematopoietic and lymphoid	KMS12BM	9.2
Haematopoietic and lymphoid	KMS18	9.7
Haematopoietic and lymphoid	KMS20	9.1
Haematopoietic and lymphoid	KMS21BM	8.6
Haematopoietic and lymphoid	KMS26	8.9
Haematopoietic and lymphoid	KMS27	8.7
Haematopoietic and lymphoid	KMS28BM	8.7
Haematopoietic and lymphoid	KMS34	8.7
Haematopoietic and lymphoid	KO52	10
Haematopoietic and lymphoid	KOPN8	10.3
Haematopoietic and lymphoid	KU812	10.9
Haematopoietic and lymphoid	KYO1	10.1
Haematopoietic and lymphoid	L1236	8.5
Haematopoietic and lymphoid	L363	8.8
Haematopoietic and lymphoid	L428	8.3
Haematopoietic and lymphoid	L540	9.1
Haematopoietic and lymphoid	LAMA84	9.5
Haematopoietic and lymphoid	LOUCY	9.8
Haematopoietic and lymphoid	LP1	8.8
Haematopoietic and lymphoid	M07E	10.2
Haematopoietic and lymphoid	MC116	9.8
Haematopoietic and lymphoid	ME1	10.5
Haematopoietic and lymphoid	MEC1	9.2
Haematopoietic and lymphoid	MEC2	9.3
Haematopoietic and lymphoid	MEG01	9.8
Haematopoietic and lymphoid	MHHCALL2	9.5
Haematopoietic and lymphoid	MHHCALL3	9.8
Haematopoietic and lymphoid	MHHCALL4	9.9
Haematopoietic and lymphoid	MINO	10.1
Haematopoietic and lymphoid	MJ	10
Haematopoietic and lymphoid	MM1S	8.1
Haematopoietic and lymphoid	MOLM13	9
Haematopoietic and lymphoid	MOLM16	10.5
Haematopoietic and lymphoid	MOLM6	10.4
Haematopoietic and lymphoid	MOLP2	8.1
Haematopoietic and lymphoid	MOLP8	9.6
Haematopoietic and lymphoid	MOLT13	10.5
Haematopoietic and lymphoid	MOLT16	9.4
Haematopoietic and lymphoid	MOLT4	10.2
Haematopoietic and lymphoid	MONOMAC1	9.1
Haematopoietic and lymphoid	MONOMAC6	9.6
Haematopoietic and lymphoid	MOTN1	8.7
Haematopoietic and lymphoid	MUTZ5	9.8
Haematopoietic and lymphoid	MV411	8.6
Haematopoietic and lymphoid	NALM19	10.1
Haematopoietic and lymphoid	NALM1	10.2
Haematopoietic and lymphoid	NALM6	10.2
Haematopoietic and lymphoid	NAMALWA	10.1
Haematopoietic and lymphoid	NB4	9.8
Haematopoietic and lymphoid	NCIH929	8.1
Haematopoietic and lymphoid	NCO2	9.6
Haematopoietic and lymphoid	NOMO1	9.3
Haematopoietic and lymphoid	NUDHL1	10
Haematopoietic and lymphoid	NUDUL1	10.6
Haematopoietic and lymphoid	OCIAML2	9.2
Haematopoietic and lymphoid	OCIAML3	9.3
Haematopoietic and lymphoid	OCIAML5	9.4
Haematopoietic and lymphoid	OCILY10	9.5
Haematopoietic and lymphoid	OCILY19	10.4
Haematopoietic and lymphoid	OCILY3	8.8
Haematopoietic and lymphoid	OCIM1	9.9
Haematopoietic and lymphoid	OPM2	8.1
Haematopoietic and lymphoid	P12ICHIKAWA	10.7
Haematopoietic and lymphoid	P31FUJ	8.5
Haematopoietic and lymphoid	P3HR1	8.9
Haematopoietic and lymphoid	PCM6	8.5
Haematopoietic and lymphoid	PEER	10.5
Haematopoietic and lymphoid	PF382	10.3
Haematopoietic and lymphoid	PFEIFFER	9.8
Haematopoietic and lymphoid	PL21	9.2
Haematopoietic and lymphoid	RAJI	9.5
Haematopoietic and lymphoid	RCHACV	10.7
Haematopoietic and lymphoid	REC1	9.7
Haematopoietic and lymphoid	REH	10.3
Haematopoietic and lymphoid	RI1	9.9
Haematopoietic and lymphoid	RL	9.6
Haematopoietic and lymphoid	RPMI8226	8.9
Haematopoietic and lymphoid	RPMI8402	10.9
Haematopoietic and lymphoid	RS411	9.2
Haematopoietic and lymphoid	SEM	9.5
Haematopoietic and lymphoid	SET2	10.4
Haematopoietic and lymphoid	SIGM5	9.1
Haematopoietic and lymphoid	SKM1	9.3
Haematopoietic and lymphoid	SKMM2	9.2
Haematopoietic and lymphoid	SR786	8.6
Haematopoietic and lymphoid	ST486	9.4
Haematopoietic and lymphoid	SUDHL10	10.1
Haematopoietic and lymphoid	SUDHL1	9.2
Haematopoietic and lymphoid	SUDHL4	10
Haematopoietic and lymphoid	SUDHL5	9.5
Haematopoietic and lymphoid	SUDHL6	9.4
Haematopoietic and lymphoid	SUDHL8	9.9
Haematopoietic and lymphoid	SUPB15	9.5
Haematopoietic and lymphoid	SUPHD1	9.1
Haematopoietic and lymphoid	SUPM2	8.8
Haematopoietic and lymphoid	SUPT11	10.5
Haematopoietic and lymphoid	SUPT1	10
Haematopoietic and lymphoid	TALL1	10.2
Haematopoietic and lymphoid	TF1	10.1
Haematopoietic and lymphoid	THP1	9
Haematopoietic and lymphoid	TO175T	8.2
Haematopoietic and lymphoid	TOLEDO	9.4
Haematopoietic and lymphoid	U266B1	7.9
Haematopoietic and lymphoid	U937	9.7
Haematopoietic and lymphoid	UT7	9.7
Haematopoietic and lymphoid	WSUDLCL2	9.9
Kidney	769P	8.1
Kidney	786O	9.6
Kidney	A498	8.2
Kidney	A704	6.7
Kidney	ACHN	7.8
Kidney	BFTC909	9.4
Kidney	CAKI1	8.6
Kidney	CAKI2	8.6
Kidney	CAL54	9
Kidney	KMRC1	8.5
Kidney	KMRC20	8.9
Kidney	KMRC2	7.9
Kidney	KMRC3	7.2
Kidney	OSRC2	8.8
Kidney	RCC10RGB	8.3
Kidney	SNU1272	9.2
Kidney	SNU349	8.8
Kidney	TUHR10TKB	9.1
Kidney	TUHR14TKB	7.9
Kidney	TUHR4TKB	8.6
Kidney	VMRCRCW	8
Kidney	VMRCRCZ	7.6
Large intestine	C2BBE1	8.8
Large intestine	CCK81	10.1
Large intestine	CL11	9.6
Large intestine	CL14	8.8
Large intestine	CL34	9.4
Large intestine	CL40	9.7
Large intestine	COLO205	8.8
Large intestine	COLO320	10.7
Large intestine	COLO678	10.4
Large intestine	CW2	10.2
Large intestine	DLD1	10.1
Large intestine	GP2D	10.4
Large intestine	HCC56	9.1
Large intestine	HCT116	10.3
Large intestine	HCT15	9.8
Large intestine	HS675T	8.2
Large intestine	HS698T	8.3
Large intestine	HT115	9.6
Large intestine	HT29	9.3
Large intestine	HT55	8.7
Large intestine	KM12	9.1
Large intestine	LOVO	8.7
Large intestine	LS1034	8.7
Large intestine	LS123	9.8
Large intestine	LS180	9.3
Large intestine	LS411N	9.2
Large intestine	LS513	8.1
Large intestine	MDST8	8.8
Large intestine	NCIH508	8.4
Large intestine	NCIH716	9.3
Large intestine	NCIH747	8.5
Large intestine	OUMS23	10.8
Large intestine	RCM1	8.2
Large intestine	RKO	8.9
Large intestine	SKCO1	9.2
Large intestine	SNU1040	10.3
Large intestine	SNU1197	9.3
Large intestine	SNU175	10.4
Large intestine	SNU283	9.4
Large intestine	SNU407	9.8
Large intestine	SNU503	9.7
Large intestine	SNU61	9.3
Large intestine	SNU81	9
Large intestine	SNUC1	9.7
Large intestine	SNUC2A	9.2
Large intestine	SNUC4	9.9
Large intestine	SNUC5	9.4
Large intestine	SW1116	8.6
Large intestine	SW1417	8.5
Large intestine	SW1463	9.5
Large intestine	SW403	9.1
Large intestine	SW480	8.5
Large intestine	SW48	9.4
Large intestine	SW620	9.8
Large intestine	SW837	9.7
Large intestine	SW948	8.9
Large intestine	T84	8.9
Liver	ALEXANDERCELLS	8.6
Liver	C3A	10.1
Liver	HEP3B217	9.1
Liver	HEPG2	9.6
Liver	HLE	9
Liver	HLF	9
Liver	HUH1	8.6
Liver	HUH6	10.3
Liver	HUH7	9.1
Liver	JHH1	8.7
Liver	JHH2	8.7
Liver	JHH4	8.9
Liver	JHH5	9.4
Liver	JHH6	8.4
Liver	JHH7	10.1
Liver	LI7	9
Liver	PLCPRF5	8.5
Liver	SKHEP1	9.5
Liver	SNU182	9.2
Liver	SNU387	8.7
Liver	SNU398	8.8
Liver	SNU423	8.5
Liver	SNU449	8.8
Liver	SNU475	9
Liver	SNU761	8.9
Liver	SNU878	8.1
Liver	SNU886	9.4
Lung	A549	8.9
Lung	ABC1	8.6
Lung	BEN	8.7
Lung	CAL12T	8.7
Lung	CALU1	9.2
Lung	CALU3	8.9
Lung	CALU6	8.8
Lung	CHAGOK1	8.6
Lung	COLO668	10.4
Lung	COLO699	9.3
Lung	CORL105	7.9
Lung	CORL23	9.3
Lung	CORL24	9.1
Lung	CORL279	11.3
Lung	CORL311	10.6
Lung	CORL47	10.5
Lung	CORL51	10.6
Lung	CORL88	10.7
Lung	CORL95	9.7
Lung	CPCN	9.6
Lung	DMS114	10.7
Lung	DMS153	9.4
Lung	DMS273	10.8
Lung	DMS454	9
Lung	DMS53	9
Lung	DMS79	10.7
Lung	DV90	9.4
Lung	EBC1	9.2
Lung	EPLC272H	8.6
Lung	HARA	9.2
Lung	HCC1171	8.7
Lung	HCC1195	9.3
Lung	HCC15	9
Lung	HCC2279	8.7
Lung	HCC2935	8.3
Lung	HCC33	10.8
Lung	HCC366	8.6
Lung	HCC4006	8.7
Lung	HCC44	8.5
Lung	HCC78	8.7
Lung	HCC827	9.4
Lung	HCC95	9.1
Lung	HLC1	9.6
Lung	HLFA	7.9
Lung	HS229T	8.8
Lung	HS618T	8.3
Lung	IALM	9.6
Lung	KNS62	8.6
Lung	LC1F	8.3
Lung	LC1SQSF	8.6
Lung	LCLC103H	9.5
Lung	LCLC97TM1	9.4
Lung	LK2	11
Lung	LOUNH91	8.7
Lung	LU65	9.5
Lung	LU99	8.9
Lung	LUDLU1	8.8
Lung	LXF289	9.1
Lung	MORCPR	9.2
Lung	NCIH1048	9.4
Lung	NCIH1092	10.5
Lung	NCIH1105	10.7
Lung	NCIH1155	9.6
Lung	NCIH1184	10.1
Lung	NCIH1299	9.3
Lung	NCIH1339	9.2
Lung	NCIH1341	10
Lung	NCIH1355	9
Lung	NCIH1373	8.4
Lung	NCIH1385	8.4
Lung	NCIH1395	7.1
Lung	NCIH1435	9.2
Lung	NCIH1436	10.1
Lung	NCIH1437	8.9
Lung	NCIH146	9.3
Lung	NCIH1563	8.1
Lung	NCIH1568	8.7
Lung	NCIH1573	8.3
Lung	NCIH1581	9.9
Lung	NCIH1618	10
Lung	NCIH1623	8.3
Lung	NCIH1648	8
Lung	NCIH1650	8.7
Lung	NCIH1651	8.8
Lung	NCIH1666	8.4
Lung	NCIH1693	9.2
Lung	NCIH1694	9.7
Lung	NCIH1703	8.7
Lung	NCIH1734	8.7
Lung	NCIH1755	9.1
Lung	NCIH1781	8.4
Lung	NCIH1792	9.3
Lung	NCIH1793	8.4
Lung	NCIH1836	9.5
Lung	NCIH1838	8.6
Lung	NCIH1869	9.1
Lung	NCIH1876	10.1
Lung	NCIH1915	8.7
Lung	NCIH1930	10.1
Lung	NCIH1944	7.9
Lung	NCIH1963	9.5
Lung	NCIH196	8.6
Lung	NCIH1975	8.7
Lung	NCIH2009	9.5
Lung	NCIH2023	8.5
Lung	NCIH2029	9.4
Lung	NCIH2030	9.1
Lung	NCIH2066	9.1
Lung	NCIH2081	10.5
Lung	NCIH2085	9
Lung	NCIH2087	9.2
Lung	NCIH209	8.8
Lung	NCIH2106	10.2
Lung	NCIH2110	9.1
Lung	NCIH211	10.7
Lung	NCIH2122	8.8
Lung	NCIH2126	8.7
Lung	NCIH2141	10.6
Lung	NCIH2170	9.3
Lung	NCIH2171	10.9
Lung	NCIH2172	8.8
Lung	NCIH2196	9.4
Lung	NCIH2227	9.8
Lung	NCIH2228	8.3
Lung	NCIH226	8.7
Lung	NCIH2286	9.6
Lung	NCIH2291	8.8
Lung	NCIH2342	8.7
Lung	NCIH2347	8.8
Lung	NCIH23	9.2
Lung	NCIH2405	8.3
Lung	NCIH2444	8.7
Lung	NCIH292	8.1
Lung	NCIH322	8.4
Lung	NCIH3255	9
Lung	NCIH358	9.6
Lung	NCIH441	9.2
Lung	NCIH446	10.9
Lung	NCIH460	9.1
Lung	NCIH510	9.2
Lung	NCIH520	9.5
Lung	NCIH522	10.6
Lung	NCIH524	10.4
Lung	NCIH526	10.9
Lung	NCIH596	8.7
Lung	NCIH647	9.3
Lung	NCIH650	9.1
Lung	NCIH661	8.7
Lung	NCIH69	9.3
Lung	NCIH727	9.8
Lung	NCIH810	10.4
Lung	NCIH82	10.7
Lung	NCIH838	9.2
Lung	NCIH841	10.4
Lung	NCIH854	9.7
Lung	NCIH889	10
Lung	PC14	10
Lung	RERFLCAD1	8.4
Lung	RERFLCAD2	8.4
Lung	RERFLCAI	9.1
Lung	RERFLCKJ	8
Lung	RERFLCMS	8.7
Lung	RERFLCSQ1	8.4
Lung	SBC5	9.8
Lung	SCLC21H	11.1
Lung	SHP77	10.3
Lung	SKLU1	8.8
Lung	SKMES1	8.7
Lung	SQ1	9.1
Lung	SW1271	8.7
Lung	SW1573	9
Lung	SW900	8.2
Lung	VMRCLCD	10.9
Lung	VMRCLCP	9.8
Oesophagus	COLO680N	10
Oesophagus	ECGI10	8.4
Oesophagus	KYSE140	9.1
Oesophagus	KYSE150	8.7
Oesophagus	KYSE180	9.5
Oesophagus	KYSE270	9.7
Oesophagus	KYSE30	8.3
Oesophagus	KYSE410	9.5
Oesophagus	KYSE450	8.8
Oesophagus	KYSE510	9.5
Oesophagus	KYSE520	9.2
Oesophagus	KYSE70	8.3
Oesophagus	OE19	8.7
Oesophagus	OE33	8.2
Oesophagus	TE10	10.1
Oesophagus	TE11	9.1
Oesophagus	TE14	9.2
Oesophagus	TE15	9
Oesophagus	TE1	10.4
Oesophagus	TE4	9.2
Oesophagus	TE5	8.1
Oesophagus	TE6	9.7
Oesophagus	TE8	9.7
Oesophagus	TE9	9.8
Oesophagus	TT	8.8
Ovary	59M	10.1
Ovary	A2780	10.4
Ovary	CAOV3	9.9
Ovary	CAOV4	9.3
Ovary	COLO704	10
Ovary	COV318	9.5
Ovary	COV362	9.1
Ovary	COV434	9
Ovary	COV504	9.1
Ovary	COV644	8.5
Ovary	EFO21	9
Ovary	EFO27	11.7
Ovary	ES2	9.2
Ovary	FUOV1	8.8
Ovary	HEYA8	8.6
Ovary	HS571T	7.5
Ovary	IGROV1	10
Ovary	JHOC5	9.7
Ovary	JHOM1	9.6
Ovary	JHOM2B	9.4
Ovary	JHOS2	10.7
Ovary	JHOS4	8.7
Ovary	KURAMOCHI	10.3
Ovary	MCAS	10.5
Ovary	NIHOVCAR3	8.8
Ovary	OAW28	9
Ovary	OAW42	9.5
Ovary	OC314	9.3
Ovary	OC316	9.2
Ovary	ONCODG1	9.7
Ovary	OV56	8.7
Ovary	OV7	9.7
Ovary	OV90	9.7
Ovary	OVCAR4	8.8
Ovary	OVCAR8	9.5
Ovary	OVISE	8.7
Ovary	OVK18	10.5
Ovary	OVKATE	8
Ovary	OVMANA	9.1
Ovary	OVSAHO	9.8
Ovary	OVTOKO	8.4
Ovary	RMGI	8.9
Ovary	RMUGS	8.7
Ovary	SKOV3	9.8
Ovary	SNU119	9.4
Ovary	SNU840	9.2
Ovary	SNU8	10.5
Ovary	TOV112D	10
Ovary	TOV21G	9.2
Ovary	TYKNU	9.4
Pancreas	ASPC1	9.9
Pancreas	BXPC3	9.4
Pancreas	CAPAN1	8.4
Pancreas	CAPAN2	9.7
Pancreas	CFPAC1	8.6
Pancreas	DANG	9
Pancreas	HPAC	9.6
Pancreas	HPAFII	8.2
Pancreas	HS766T	9
Pancreas	HUPT3	8.6
Pancreas	HUPT4	9.5
Pancreas	KCIMOH1	8.8
Pancreas	KLM1	11.1
Pancreas	KP2	10.2
Pancreas	KP3	8.8
Pancreas	KP4	9.6
Pancreas	L33	8.8
Pancreas	MIAPACA2	9.4
Pancreas	PANC0203	9.2
Pancreas	PANC0213	7.1
Pancreas	PANC0327	8.3
Pancreas	PANC0403	8.6
Pancreas	PANC0504	9.6
Pancreas	PANC0813	8.8
Pancreas	PANC1005	8.4
Pancreas	PANC1	9.2
Pancreas	PATU8902	8.1
Pancreas	PATU8988S	8.3
Pancreas	PATU8988T	9
Pancreas	PK1	8.8
Pancreas	PK45H	8.9
Pancreas	PK59	11
Pancreas	PL45	8
Pancreas	PSN1	9.7
Pancreas	QGP1	8.5
Pancreas	SNU213	9.2
Pancreas	SNU324	9.4
Pancreas	SNU410	8.5
Pancreas	SU8686	8.5
Pancreas	SUIT2	8.4
Pancreas	SW1990	8.8
Pancreas	T3M4	9.3
Pancreas	TCCPAN2	8.5
Pancreas	YAPC	9.3
Pleura	ACCMESO1	9.3
Pleura	DM3	8.5
Pleura	ISTMES1	8.1
Pleura	ISTMES2	8.7
Pleura	JL1	9.6
Pleura	MPP89	8.9
Pleura	MSTO211H	9.3
Pleura	NCIH2052	8.6
Pleura	NCIH2452	8.5
Pleura	NCIH28	8
Prostate	22RV1	8.3
Prostate	DU145	8.9
Prostate	LNCAPCLONEFGC	8.5
Prostate	MDAPCA2B	9.7
Prostate	NCIH660	8.6
Prostate	PC3	9.4
Prostate	VCAP	9.1
Salivary gland	A253	9.2
Salivary gland	YD15	9.2
Skin	A101D	8.6
Skin	A2058	9.1
Skin	A375	9.7
Skin	C32	7.9
Skin	CHL1	9.3
Skin	CJM	8.7
Skin	COLO679	9.1
Skin	COLO741	8.7
Skin	COLO783	9
Skin	COLO792	8.8
Skin	COLO800	8.7
Skin	COLO818	8.4
Skin	COLO829	8.5
Skin	COLO849	8.7
Skin	G361	10
Skin	GRM	9.7
Skin	HMCB	9.5
Skin	HS294T	8.8
Skin	HS600T	8.1
Skin	HS688AT	8.2
Skin	HS695T	8.2
Skin	HS839T	8.3
Skin	HS852T	8.7
Skin	HS895T	7.8
Skin	HS934T	8.6
Skin	HS936T	8.5
Skin	HS939T	8.2
Skin	HS940T	8
Skin	HS944T	9.4
Skin	HT144	8.7
Skin	IGR1	9.7
Skin	IGR37	9.3
Skin	IGR39	9.2
Skin	IPC298	8.7
Skin	K029AX	10.1
Skin	LOXIMVI	9.2
Skin	MALME3M	8.3
Skin	MDAMB435S	8.2
Skin	MELHO	9.6
Skin	MELJUSO	8.6
Skin	MEWO	10
Skin	RPMI7951	9.1
Skin	RVH421	8.4
Skin	SH4	8.6
Skin	SKMEL1	8
Skin	SKMEL24	8.4
Skin	SKMEL28	10.2
Skin	SKMEL2	8.7
Skin	SKMEL30	9.1
Skin	SKMEL31	8.4
Skin	SKMEL3	8.9
Skin	SKMEL5	8.5
Skin	UACC257	9.5
Skin	UACC62	9.1
Skin	WM115	8.5
Skin	WM1799	9.1
Skin	WM2664	8.8
Skin	WM793	8.9
Skin	WM88	9.2
Skin	WM983B	8.8
Small intestine	HUTU80	9.6
Soft tissue	A204	9.4
Soft tissue	G401	9.7
Soft tissue	G402	9.6
Soft tissue	GCT	9
Soft tissue	HS729	8.9
Soft tissue	HT1080	9
Soft tissue	KYM1	9.7
Soft tissue	MESSA	9.5
Soft tissue	RD	10.1
Soft tissue	RH30	10.7
Soft tissue	RH41	10.4
Soft tissue	RKN	8.2
Soft tissue	S117	9.4
Soft tissue	SJRH30	10.1
Soft tissue	SKLMS1	8.9
Soft tissue	SKUT1	10.1
Soft tissue	TE125T	8.2
Soft tissue	TE159T	8
Soft tissue	TE441T	9
Soft tissue	TE617T	9.1
Stomach	2313287	9.1
Stomach	AGS	8.9
Stomach	AZ521	10.1
Stomach	ECC10	9.7
Stomach	ECC12	10
Stomach	FU97	8.5
Stomach	GCIY	9.5
Stomach	GSS	9.6
Stomach	GSU	9.3
Stomach	HGC27	9.5
Stomach	HS746T	8.8
Stomach	HUG1N	9
Stomach	IM95	9.5
Stomach	KATOIII	8.6
Stomach	KE39	9
Stomach	LMSU	10.1
Stomach	MKN1	10.9
Stomach	MKN45	10.6
Stomach	MKN74	7.8
Stomach	MKN7	11.7
Stomach	NCCSTCK140	9.2
Stomach	NCIN87	8.8
Stomach	NUGC2	10.7
Stomach	NUGC3	9.8
Stomach	NUGC4	8.4
Stomach	OCUM1	9.2
Stomach	RERFGC1B	9.2
Stomach	SH10TC	9.1
Stomach	SNU16	9.7
Stomach	SNU1	8.9
Stomach	SNU216	9.7
Stomach	SNU520	9
Stomach	SNU5	8
Stomach	SNU601	9.9
Stomach	SNU620	9
Stomach	SNU668	9.4
Stomach	SNU719	9.5
Stomach	TGBC11TKB	10.1
Thyroid	8305C	9.8
Thyroid	8505C	9.4
Thyroid	BCPAP	10.1
Thyroid	BHT101	9.2
Thyroid	CAL62	9.4
Thyroid	CGTHW1	9.5
Thyroid	FTC133	10
Thyroid	FTC238	9.9
Thyroid	ML1	9.2
Thyroid	SW579	9.2
Thyroid	TT2609C02	9.4
Thyroid	TT	8.4
Upper aerodigestive tract	BHY	8.6
Upper aerodigestive tract	BICR16	9.3
Upper aerodigestive tract	BICR18	9
Upper aerodigestive tract	BICR22	9.4
Upper aerodigestive tract	BICR31	9.1
Upper aerodigestive tract	BICR56	9.5
Upper aerodigestive tract	BICR6	9.8
Upper aerodigestive tract	CAL27	9.7
Upper aerodigestive tract	CAL33	9.2
Upper aerodigestive tract	DETROIT562	8.8
Upper aerodigestive tract	FADU	8.8
Upper aerodigestive tract	HS840T	8.3
Upper aerodigestive tract	HSC2	8.7
Upper aerodigestive tract	HSC3	9.1
Upper aerodigestive tract	HSC4	8.9
Upper aerodigestive tract	PECAPJ15	10.8
Upper aerodigestive tract	PECAPJ34CLONEC12	10.1
Upper aerodigestive tract	PECAPJ41CLONED2	9.2
Upper aerodigestive tract	PECAPJ49	9.6
Upper aerodigestive tract	SCC15	9.8
Upper aerodigestive tract	SCC25	10.1
Upper aerodigestive tract	SCC4	8.8
Upper aerodigestive tract	SCC9	9
Upper aerodigestive tract	SNU1076	9.1
Upper aerodigestive tract	SNU1214	8.8
Upper aerodigestive tract	SNU46	9
Upper aerodigestive tract	SNU899	9
Upper aerodigestive tract	YD10B	9.1
Upper aerodigestive tract	YD38	9.2
Upper aerodigestive tract	YD8	9.1
Urinary tract	5637	9.9
Urinary tract	639V	10.2
Urinary tract	647V	9.9
Urinary tract	BC3C	9.8
Urinary tract	BFTC905	10.2
Urinary tract	CAL29	9.9
Urinary tract	HS172T	7.7
Urinary tract	HT1197	10.4
Urinary tract	HT1376	8.2
Urinary tract	J82	8.9
Urinary tract	JMSU1	9.8
Urinary tract	KMBC2	9.1
Urinary tract	KU1919	9.6
Urinary tract	RT11284	10.7
Urinary tract	RT112	10.4
Urinary tract	RT4	8.5
Urinary tract	SCABER	9.8
Urinary tract	SW1710	9.8
Urinary tract	SW780	9.8
Urinary tract	T24	8.9
Urinary tract	TCCSUP	9.9
Urinary tract	UMUC1	9.5
Urinary tract	UMUC3	9.1
Urinary tract	VMCUB1	9.4

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	23
Adrenal gland	37.5
Appendix	35.1
Bone marrow	35.1
Breast	43.3
Cerebral cortex	38.7
Cervix, uterine	44.1
Colon	32.7
Duodenum	27.4
Endometrium	66.5
Epididymis	68
Esophagus	30.3
Fallopian tube	59.1
Gallbladder	41.4
Heart muscle	16
Kidney	30.5
Liver	12.5
Lung	37.2
Lymph node	42.5
Ovary	53.1
Pancreas	5.4
Parathyroid gland	78.2
Placenta	49.6
Prostate	60
Rectum	43.7
Salivary gland	12.8
Seminal vesicle	49.4
Skeletal muscle	13.6
Skin	48.8
Small intestine	30.1
Smooth muscle	49.4
Spleen	34.8
Stomach	23
Testis	163.3
Thyroid gland	51.1
Tonsil	40
Urinary bladder	36.9

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
27572339	overexpression	Breast Carcinoma	LSD1 is overexpressed in various cancers including breast cancer, but its functional roles in tumourigenesis are not fully understood.
27349498	overexpression	Castration-Resistant Prostate Carcinoma	Lysine-specific demethylase 1 (LSD1 or KDM1A) overexpression correlates with poor survival and castration resistance in prostate cancer.
27212032	overexpression	Breast Carcinoma	Protein expression of HDAC5 and LSD1 was significantly increased in primary breast cancer specimens in comparison with matched-normal adjacent tissues.
27058897	overexpression	Non-Small Cell Lung Carcinoma	Finally, high expression of KDM1A and low expression of TIMP3 significantly correlate with a poor prognosis in NSCLC patients.
26872725	overexpression	Oral Cavity Squamous Cell Carcinoma	Here we sought to interrogate the oncogenic roles of LSD1 in OSCC tumorigenesis and therapeutic intervention by integrating chemical-induced OSCC model, genetic and pharmacological loss-of-function approaches.
26848860	overexpression	Ewing Sarcoma	High LSD1 expression is observed in Ewing sarcoma patient samples and mechanistic and preclinical data suggest LSD1 inhibition globally disrupts the function of EWS-ETS proteins.
26534764	overexpression	Prostate Carcinoma	Our data showed that LSD1 was overexpressed in human PCa specimens and in AI PCa LNCaP-AI cells, which were established through a three-month continuous culture of LNCaP cells in androgen-deprived medium.
26489763	overexpression	Ovarian Neoplasm	Lysine-specific demethylase 1 (LSD1/KDM1A) acts as an epigenetic regulator and is overexpressed in ovarian tumors.
26460616	overexpression	Gallbladder Carcinoma	We found GBC tissues had upregulated LSD1 compared with normal gallbladder tissues (P = 0.003), and its high expression was associated with tumor-node-metastasis stage (P < 0.0001), Nevin's stage (P = 0.0093) and distant metastases (P = 0.0070).
26435505	overexpression	Castration-Resistant Prostate Carcinoma	The results showed that LSD1 expression was up-regulated when PCa progressed to Castration Resistant Prostate Cancer (CRPC).
26225839	overexpression	Oral Neoplasm	By comparing mRNA expression profiles, we identified an elevated KDM1A expression in oral tumors when compared to normal oral tissues.
26166558	overexpression	Endometrial Endometrioid Adenocarcinoma	Compared with normal endometrium and benign endometrial lesion (both P < 0.001), LSD1 was overexpressed in EEA.
25956476	overexpression	Ovarian Carcinoma	The positive ratio of LSD1 expression was 50% in normal ovarian epithelial tissues, 72% in serous cystadenoma, 73% in mucinous cystadenoma, 82% in borderline serous cystadenoma, 83% in borderline mucinous cystadenoma, 94% in serous cystadenocarcinoma and 92% in mucinous cystadenocarcinoma, respectively.
25759518	overexpression	Neuroblastoma; Breast Carcinoma; Hepatocellular Carcinoma	Lysine-specific demethylase 1 (LSD1/KDM1A), a histone-modifying enzyme, is upregulated in many cancers, especially in neuroblastoma, breast cancer and hepatoma.
25682387	overexpression	Tongue Neoplasm	Further, immunohistochemical analyses of tongue tumors induced by CAL27 and UMSCC2 cells revealed elevated expression of components of protumorigenic pathways deregulated in human cancers, including Cyclin D1, PCNA, Ki-67, LSD1, LOXL2, MT-MMP1, DPAGT1, E-cadherin, OCT4A, and H3K4me1/2.
25679396	overexpression	Breast Carcinoma	In breast cancer, the significance of LSD1 overexpression is not clear.
25674267	overexpression	Esophageal Carcinoma	We found that the positive LSD1 immunochemical staining was predominantly observed on the nuclei and cytoplasm of esophageal cancer cells, while negative or very weak in adjacent normal tissues.
25627913	overexpression	Prostate Carcinoma	LSD1 expression increased significantly in prostate cancer specimens compared with benign prostatic hyperplasia (P < 0.05).
25605246	overexpression	Prostate Carcinoma	Finally, LSD1 expression in human cancer specimens was significantly higher than that in normal prostate glands.
25139823	overexpression	Breast Carcinoma	Expression of LSD1 and SIRT1, but not of HDAC2, was significantly increased in tumor tissues compared to their normal counterparts (both p < 0.001).
25060070	overexpression	Colorectal Carcinoma	LSD1 expression was significantly elevated in colorectal tumor tissues compared with adjacent adenoma and normal colorectal tissues (P < 0.001), and LSD1 levels were significantly correlated with an advanced AJCC T stage (P = 0.012) and distant metastasis (P = 0.004).
25040359	overexpression	Tongue Carcinoma	Upregulated LSD1 expression was observed in tongue cancer cells and a major fraction of tongue SCC samples.
24658378	overexpression	Melanoma	Overexpression of EHMT2, SETDB1, and LSD1 was observed in 14 (21%), 38 (57%), and 53 (79%) of the 67 patients, respectively.
24561118	overexpression	Pancreatic Carcinoma	Our study investigated the role of LSD1 in pancreatic cancer and demonstrated that LSD1 was significantly up-regulated in pancreatic cancer patient tissue samples, and elevated LSD1 protein levels positively correlated with overall survival of pancreatic cancer patients.
24406160	overexpression	Neuroblastoma	Lysine-specific demethylase 1 (LSD1) is upregulated in many cancers, especially neuroblastoma.
24252778	overexpression	Medulloblastoma	Re-analysis of gene expression data and immunohistochemistry of tissue microarrays of human medulloblastomas showed strong KDM1A overexpression in the majority of tumors throughout all molecular subgroups.
24165091	overexpression	Ovarian Neoplasm	We found moderate but consistent LSD1 mRNA overexpression in stage IIIC and high-grade ovarian tumors.
24068396	overexpression	Thyroid Gland Papillary Carcinoma	Despite the fact that both RBP2 and LSD1 expressions were higher in papillary thyroid carcinoma than in paracancerous tissues (U=-3.855, p=0.000; U=-5.575, p=0.000) and thyroid adenoma (U=-1.972, p=0.049; U=-3.190, p=0.001), they did not show us statistical correlation (r=-0.149, p=0.270).
24064254	overexpression	Bladder Carcinoma	It has also been found that LSD1 expression is elevated in clinical bladder cancer tissues compared with in normal tissues, and LSD1 knock down could significantly result in the suppression of bladder cancer cell line proliferation.
23922913	overexpression	Colorectal Carcinoma	The results showed that in 19 paired samples (86.4%), LSD1 is more highly expressed in tumor tissue than in normal tissue.
23900215	overexpression	Colon Carcinoma	Lysine-specific demethylase 1 was upregulated in colon cancer tissues, and the high LSD1 expression was significantly associated with tumour-node-metastasis (TNM) stages and distant metastasis.
23816987	overexpression	Neuroblastoma	LSD1 expression was higher in NB compared to GNB, and LSD1 overexpression directly correlated with Bcl-2 expression and inversely correlated with Bax expression.
23747727	overexpression	Esophageal Squamous Cell Carcinoma	Here, we reported that LSD1 expression was elevated in cancerous tissue and correlated with lymph node metastasis and poorer overall survival in patients with ESCC.
23400681	overexpression	Neuroblastoma	The histone demethylase, lysine-specific demethylase 1 (KDM1A, previously known as LSD1), is strongly expressed in neuroblastomas, and overexpression correlates with poor patient prognosis.
23384557	overexpression	Prostate Carcinoma	LSD1 is overexpressed in numerous cancers including prostate cancer through an unknown mechanism.
23314859	overexpression	Colon Carcinoma	LSD1 was significantly more highly expressed in colon cancer specimens classified as high TNM stage lesions and with distant metastasis (P < 0.05).
23248157	overexpression	Glioma	KDM1 was overexpressed in gliomas and its expression positively correlated with histological malignancy.
23236241	overexpression	Hepatocellular Carcinoma	Immunohistochemistry, Western blotting, and qRT-PCR consistently confirmed LSD1 overexpression in HCC tissues compared to adjacent non-neoplastic tissues (P < 0.01).
23015317	overexpression	Hepatocellular Carcinoma	Immunohistochemistry and Western blotting consistently confirmed LSD1 overexpression in HCC tissues compared with adjacent non-neoplastic tissues (P<0.01).
22920283	overexpression	High Grade Ductal Breast Carcinoma In Situ	Interestingly, LSD1 was significantly overexpressed in high grade DCIS versus low grade DCIS.
22493729	overexpression	Non-Small Cell Lung Carcinoma	LSD1 expression was higher in lung cancer tissue more than in normal lung tissue.
22169281	aberrant expression	Acute Leukemia	In 72 AL patients, LSD1 expression levels were quite different. LSD1 positive rate was 56.9% (41/72), average relative amount was 1.053 ± 1.976. In 17 controls, LSD1 positive rate was 0%, relative amount was 0.004 ± 0.012.
21975933	overexpression	Testicular Seminoma	In support of these results, we found that LSD1 protein level is highly elevated in pluripotent cancer cells and in human testicular seminoma tissues that express Oct4.
21805138	overexpression	Breast Carcinoma	Additionally, LSD1 is highly expressed in estrogen receptor α negative (ER-) breast cancer cells.
21400613	overexpression	Bladder Carcinoma	JMJD2A and AR levels were significantly lower in malignant versus benign urothelium, while increased LSD1 levels were observed in malignant urothelium relative to benign.
20333681	overexpression	Bladder Carcinoma	Expression levels of LSD1 are significantly elevated in human bladder carcinomas compared with nonneoplastic bladder tissues (p < 0.0001).
27632941	Overexpression	Glioma	Furthermore, USP7 and LSD1 expression levels were higher in the 150 glioma patients than these levels in normal brain tissues and were correlated with glioma progression.
27212032	Overexpression	Breast Carcinoma	Protein expression of HDAC5 and LSD1 was significantly increased in primary breast cancer specimens in comparison with matched-normal adjacent tissues.

Summary
Symbol	KDM1A
Name	lysine demethylase 1A
Aliases	KIAA0601; BHC110; LSD1; AOF2; KDM1; amine oxidase (flavin containing) domain 2; lysine (K)-specific demethyl ......
Location	1p36.12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.411	6.72e-18	19.1	61.4	19.6	Neutral
BRCA	Breast invasive carcinoma	1075	0.445	2.69e-53	40.8	53.2	6	Loss
CESC	Cervical and endocervical cancers	292	0.504	2.98e-20	11.6	61.3	27.1	Neutral
COAD	Colon adenocarcinoma	449	0.525	3.9e-33	36.3	62.1	1.6	Loss
ESCA	Esophageal carcinoma	183	0.447	2.24e-10	36.1	51.9	12	Loss
GBM	Glioblastoma multiforme	147	0.374	3.1e-06	8.8	72.8	18.4	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.322	7.9e-14	18.3	71.6	10.1	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.317	1.05e-13	18.5	80.2	1.3	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.544	1.55e-23	18.1	81.9	0	Neutral
LAML	Acute Myeloid Leukemia	166	0.179	0.0214	0.6	97	2.4	Neutral
LGG	Brain Lower Grade Glioma	513	0.639	2.85e-60	37.6	59.3	3.1	Loss
LIHC	Liver hepatocellular carcinoma	364	0.442	8.07e-19	38.2	56.6	5.2	Loss
LUAD	Lung adenocarcinoma	512	0.378	8.61e-19	23.8	53.7	22.5	Neutral
LUSC	Lung squamous cell carcinoma	498	0.477	1.24e-29	45	44.8	10.2	Loss
OV	Ovarian serous cystadenocarcinoma	300	0.732	1.72e-51	40.7	37.3	22	Loss
PAAD	Pancreatic adenocarcinoma	177	0.363	7.08e-07	32.2	64.4	3.4	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.79	8.3e-36	63	36.4	0.6	Loss
PRAD	Prostate adenocarcinoma	491	0.252	1.44e-08	9.4	89.6	1	Neutral
READ	Rectum adenocarcinoma	164	0.608	5.82e-18	44.5	53.7	1.8	Loss
SARC	Sarcoma	255	0.644	2.54e-31	15.7	53.7	30.6	Neutral
SKCM	Skin Cutaneous Melanoma	367	0.451	9.07e-20	19.1	60.5	20.4	Neutral
STAD	Stomach adenocarcinoma	413	0.379	1.51e-15	25.9	65.9	8.2	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.499	8.24e-11	19.3	64	16.7	Neutral
THCA	Thyroid carcinoma	497	0.269	1.07e-09	0.8	98.8	0.4	Neutral
THYM	Thymoma	119	0.289	0.00141	7.6	91.6	0.8	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.472	4.43e-31	14.3	78.8	6.9	Neutral

Summary
Symbol	KDM1A
Name	lysine demethylase 1A
Aliases	KIAA0601; BHC110; LSD1; AOF2; KDM1; amine oxidase (flavin containing) domain 2; lysine (K)-specific demethyl ......
Location	1p36.12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.356	5.26e-14	17	408	-0.238	1.62e-06	Decreased
BRCA	Breast invasive carcinoma	-0.316	6.45e-22	83	785	-0.067	3.65e-06	NS/NA
CESC	Cervical and endocervical cancers	-0.448	0	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.282	3.97e-07	19	297	-0.186	8.58e-06	NS/NA
ESCA	Esophageal carcinoma	-0.296	2.99e-05	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.275	0.0272	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.265	4.62e-10	20	522	-0.114	0.000147	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.137	0.011	24	319	0.055	0.396	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.078	0.182	23	275	0.008	4.66e-05	NS/NA
LAML	Acute Myeloid Leukemia	-0.111	0.15	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.274	1.73e-10	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.308	1.85e-10	41	373	-0.204	1.27e-17	Decreased
LUAD	Lung adenocarcinoma	-0.327	3.39e-13	21	456	-0.097	1.89e-13	NS/NA
LUSC	Lung squamous cell carcinoma	-0.411	0	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.817	0.0108	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.402	2.21e-08	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.484	1.23e-14	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.479	0	35	498	-0.09	0.000223	NS/NA
READ	Rectum adenocarcinoma	-0.3	0.00238	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.196	0.00144	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.153	0.000847	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.33	8.49e-11	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.263	0.000939	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.102	0.0154	50	509	-0.001	0.224	NS/NA
THYM	Thymoma	-0.2	0.0272	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.229	6.64e-07	34	431	-0.392	3.65e-23	Decreased

Summary
Symbol	KDM1A
Name	lysine demethylase 1A
Aliases	KIAA0601; BHC110; LSD1; AOF2; KDM1; amine oxidase (flavin containing) domain 2; lysine (K)-specific demethyl ......
Location	1p36.12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	3	High
Appendix	1	Low
Bone marrow	3	High
Breast	2	Medium
Bronchus	3	High
Caudate	2	Medium
Cerebellum	3	High
Cerebral cortex	2	Medium
Cervix, uterine	2	Medium
Colon	2	Medium
Duodenum	2	Medium
Endometrium	3	High
Epididymis	2	Medium
Esophagus	2	Medium
Fallopian tube	2	Medium
Gallbladder	3	High
Heart muscle	3	High
Hippocampus	2	Medium
Kidney	3	High
Liver	2	Medium
Lung	3	High
Lymph node	2	Medium
Nasopharynx	1	Low
Oral mucosa	1	Low
Ovary	3	High
Pancreas	2	Medium
Parathyroid gland	3	High
Placenta	3	High
Prostate	0	Not detected
Rectum	2	Medium
Salivary gland	3	High
Seminal vesicle	2	Medium
Skeletal muscle	3	High
Skin	3	High
Small intestine	1	Low
Smooth muscle	1	Low
Soft tissue	3	High
Spleen	3	High
Stomach	2	Medium
Testis	2	Medium
Thyroid gland	2	Medium
Tonsil	2	Medium
Urinary bladder	2	Medium

Summary
Symbol	KDM1A
Name	lysine demethylase 1A
Aliases	KIAA0601; BHC110; LSD1; AOF2; KDM1; amine oxidase (flavin containing) domain 2; lysine (K)-specific demethyl ......
Location	1p36.12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.175	NS	24476821
BRCA	Breast invasive carcinoma	521	2.45e-16	Significant	23000897
COAD	Colon adenocarcinoma	149	0.23	NS	22810696
GBM	Glioblastoma multiforme	157	7.06e-08	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	0.00538	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.00391	Significant	26536169
LGG	Brain Lower Grade Glioma	513	7.94e-61	Significant	26824661
LUAD	Lung adenocarcinoma	230	0.000134	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	3.38e-05	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	1.48e-10	Significant	21720365
PRAD	Prostate adenocarcinoma	333	1.85e-17	Significant	26544944
READ	Rectum adenocarcinoma	67	0.0157	Significant	22810696
SKCM	Skin Cutaneous Melanoma	315	0.0117	Significant	26091043
STAD	Stomach adenocarcinoma	277	1.17e-09	Significant	25079317
THCA	Thyroid carcinoma	391	0.229	NS	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.217	NS	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	1.053	0.804	NS
BRCA	Breast invasive carcinoma	1079	1.221	0.378	NS
CESC	Cervical and endocervical cancers	291	1.324	0.446	NS
COAD	Colon adenocarcinoma	439	0.357	6e-04	Longer
ESCA	Esophageal carcinoma	184	0.864	0.667	NS
GBM	Glioblastoma multiforme	158	0.798	0.373	NS
HNSC	Head and Neck squamous cell carcinoma	518	1.343	0.131	NS
KIRC	Kidney renal clear cell carcinoma	531	0.894	0.579	NS
KIRP	Kidney renal papillary cell carcinoma	287	0.722	0.404	NS
LAML	Acute Myeloid Leukemia	149	0.776	0.393	NS
LGG	Brain Lower Grade Glioma	511	1.059	0.854	NS
LIHC	Liver hepatocellular carcinoma	365	2.448	0.000205	Shorter
LUAD	Lung adenocarcinoma	502	1.12	0.593	NS
LUSC	Lung squamous cell carcinoma	494	1.107	0.6	NS
OV	Ovarian serous cystadenocarcinoma	303	1.208	0.361	NS
PAAD	Pancreatic adenocarcinoma	177	1.841	0.0447	Shorter
PCPG	Pheochromocytoma and Paraganglioma	179	618460966.463	0.308	NS
PRAD	Prostate adenocarcinoma	497	1.794	0.524	NS
READ	Rectum adenocarcinoma	159	0.504	0.239	NS
SARC	Sarcoma	259	3.561	1.91e-05	Shorter
SKCM	Skin Cutaneous Melanoma	459	1.464	0.0534	NS
STAD	Stomach adenocarcinoma	388	1.039	0.865	NS
TGCT	Testicular Germ Cell Tumors	134	0	0.144	NS
THCA	Thyroid carcinoma	500	0.592	0.431	NS
THYM	Thymoma	119	0.499	0.448	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	1.064	0.824	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	-0.026	0.598	NS
BRCA	Breast invasive carcinoma	1071	-0.044	0.147	NS
CESC	Cervical and endocervical cancers	167	0.054	0.486	NS
COAD	Colon adenocarcinoma	445	-0.149	0.00159	Lower
ESCA	Esophageal carcinoma	162	-0.103	0.194	NS
HNSC	Head and Neck squamous cell carcinoma	448	0.201	1.84e-05	Higher
KIRC	Kidney renal clear cell carcinoma	531	-0.087	0.0455	Lower
KIRP	Kidney renal papillary cell carcinoma	260	-0.098	0.116	NS
LIHC	Liver hepatocellular carcinoma	347	0.125	0.0199	Higher
LUAD	Lung adenocarcinoma	507	0.081	0.0682	NS
LUSC	Lung squamous cell carcinoma	497	0.036	0.418	NS
OV	Ovarian serous cystadenocarcinoma	302	-0.149	0.00937	Lower
PAAD	Pancreatic adenocarcinoma	176	0.072	0.343	NS
READ	Rectum adenocarcinoma	156	-0.075	0.351	NS
SKCM	Skin Cutaneous Melanoma	410	-0.071	0.149	NS
STAD	Stomach adenocarcinoma	392	-0.018	0.728	NS
TGCT	Testicular Germ Cell Tumors	81	0.121	0.28	NS
THCA	Thyroid carcinoma	499	0.04	0.371	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	-0.006	0.889	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	0.068	0.264	NS
HNSC	Head and Neck squamous cell carcinoma	498	-0.02	0.65	NS
KIRC	Kidney renal clear cell carcinoma	525	-0.119	0.00614	Lower
LGG	Brain Lower Grade Glioma	514	0.11	0.0127	Higher
LIHC	Liver hepatocellular carcinoma	366	0.128	0.0143	Higher
OV	Ovarian serous cystadenocarcinoma	296	0.082	0.157	NS
PAAD	Pancreatic adenocarcinoma	176	0.14	0.064	NS
STAD	Stomach adenocarcinoma	406	-0.064	0.195	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.229	8.81e-08	Higher

Summary
Symbol	KDM1A
Name	lysine demethylase 1A
Aliases	KIAA0601; BHC110; LSD1; AOF2; KDM1; amine oxidase (flavin containing) domain 2; lysine (K)-specific demethyl ......
Location	1p36.12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	KDM1A
Name	lysine demethylase 1A
Aliases	KIAA0601; BHC110; LSD1; AOF2; KDM1; amine oxidase (flavin containing) domain 2; lysine (K)-specific demethyl ......
Location	1p36.12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for KDM1A.

Summary
Symbol	KDM1A
Name	lysine demethylase 1A
Aliases	KIAA0601; BHC110; LSD1; AOF2; KDM1; amine oxidase (flavin containing) domain 2; lysine (K)-specific demethyl ......
Location	1p36.12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
27572339	Breast Carcinoma	partner	PKCα	crucial for function	In addition, it has been reported that phosphorylation of the Serine 112 residue of LSD1 by PKCα is crucial for its function in gene regulation.
27572339	Breast Carcinoma	downstream	CDH1	negative regulation	LSD1 potentiates EMT in breast epithelia cells by repressing E-cadherin expression through demethylating H3K4me at gene's promoter, during which phosphorylation of LSD1 Ser112 is crucial for its binding and demethylation activity.
27212032	Breast Carcinoma	upstream	HDAC5	positive regulation	Overexpression of HDAC5 stabilized LSD1 protein and decreased the nuclear level of H3K4me1/me2 in MDA-MB-231 cells, whereas loss of HDAC5 by siRNA diminished LSD1 protein stability and demethylation activity.
26534764	Prostate Carcinoma	downstream	AR signaling pathway; p53	positive regulation; negative regulation	These findings revealed that overexpression of LSD1 promoted AI transition of PCa LNCaP cells under androgen-ablated conditions via activation of the AR signaling pathway and suppression of the p53 signaling pathway.
26489763	Ovarian Neoplasm	upstream	EGF	positive regulation	Here, we show that epidermal growth factor (EGF) signaling upregulates LSD1 protein levels in SKOV3 and HO8910 ovarian cancer cells overexpressing both LSD1 and the EGF receptor.
26460616	Gallbladder Carcinoma	downstream	c-myc	positive regulation	Inhibiting LSD1 expression in vitro impaired the proliferation and invasiveness of GBC cells and also downregulated c-myc expression and consequently inhibited GBC cell proliferation.
25679396	Breast Carcinoma	partner	BRCA1	negative correlation	Interestingly, we note that overexpression of LSD1 correlates with down-regulation of BRCA1 in triple negative breast cancer.
25627913	Prostate Carcinoma	partner	CDH1	negative correlation	Correlation analysis revealed that LSD1 expression was negatively correlated with E-cadherin expression in prostate cancer (rs = -0.486, P = 0.001).
25060070	Colorectal Carcinoma	partner	LSD1; LGR5; CTNNB1; c-Myc	positive correlation	We also observed the inactivation of β-catenin/TCF signaling after CBB1003 treatment, consistent with the positive correlations among LSD1, LGR5, β-catenin and c-Myc expression in human colon tumor and adenoma tissues.
25040359	Tongue Carcinoma	partner	Ki-67	association	Overexpression of LSD1 significantly associated with tumor size (P = 0.0357), pathological grade (P = 0.0323), Ki-67 abundance (P = 0.0148), and reduced overall and disease-free survival (Kaplan-Meier analysis, P = 0.0351, 0.0479, respectively).
24561118	Pancreatic Carcinoma	partner	HIF1α	coorperation	Mechanistically, our study demonstrated that LSD1 synergized with HIF1α (hypoxia inducible factor-1α) in maintaining glycolytic process, which fueled pancreatic cancer uncontrolled proliferation.
23922913	Colorectal Carcinoma	partner	CTNNB1	positive correlation	As DKK1 was the gene with the most significant differential expression, we analyzed the key proteins of the DKK1-related Wnt/β-catenin signaling pathway and found that, after knocking out LSD1, the amount of free β-catenin translocated to the nucleus was significantly reduced and that the transcription of the signaling pathway target gene c-Myc was down-regulated.
23922913	Colorectal Carcinoma	downstream	c-Myc	positive regulation	As DKK1 was the gene with the most significant differential expression, we analyzed the key proteins of the DKK1-related Wnt/β-catenin signaling pathway and found that, after knocking out LSD1, the amount of free β-catenin translocated to the nucleus was significantly reduced and that the transcription of the signaling pathway target gene c-Myc was down-regulated.
23816987	Neuroblastoma	partner	Bcl-2; Bax	positive correlation; negative correlation	LSD1 expression was higher in NB compared to GNB, and LSD1 overexpression directly correlated with Bcl-2 expression and inversely correlated with Bax expression.
23400681	Neuroblastoma	upstream	miR-137	negative regulation	KDM1A mRNA was repressed by miR-137 in neuroblastoma cells, and was validated as a direct target of miR-137 using reporter assays in SHEP and HEK293 cells.
23384557	Prostate Carcinoma	downstream	VEGF-A; PSA; Tmprss2	positive regulation	We show that functional depletion of LSD1 expression using siRNA in prostate cancer cells decreases VEGF-A and blocks androgen induced VEGF-A, PSA and Tmprss2 expression.
23314859	Colon Carcinoma	partner	CDH1	negative correlation	Correlation analysis revealed that LSD1 expression was negatively correlated with E-cadherin expression (r s = -0.318, P = 0.001), but not evidently correlated with N-cadherin expression (r s = 0.182, P = 0.06).
23015317	Hepatocellular Carcinoma	downstream	BRCA1	negative regulation	Consistent with recent studies describing correlative associations in basal-like breast cancers between Wnt signaling, increased Slug levels, and reduced expression of the tumor suppressor Breast Cancer 1, Early Onset (BRCA1), further studies demonstrate that Slug-as well as Snail-directly represses BRCA1 expression by recruiting the chromatin-demethylase, LSD1, and binding to a series of E-boxes located within the BRCA1 promoter.
27632941	Glioma	partner	USP7	correlation	LSD1 was increased concurrently with USP7 during glioblastoma progression and both were predictors for worsened prognosis.