CR2Cancer

Summary
Symbol	KDM2A
Name	lysine demethylase 2A
Aliases	KIAA1004; FBL11; LILINA; DKFZP434M1735; FLJ00115; CXXC8; JHDM1A; F-box protein FBL11; jumonji C domain-conta ......
Location	11q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

[ TOP ]

Domain

PF00646 F-box domain
PF02373 JmjC domain
PF16866 PHD-finger
PF02008 CXXC zinc finger domain

Function

Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis.

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification erase	Histone methylation	H3K36me2	H3K36	20417597

> Gene Ontology [ TOP ]
Biological Process	GO:0000726 non-recombinational repair GO:0006302 double-strand break repair GO:0006303 double-strand break repair via nonhomologous end joining GO:0006482 protein demethylation GO:0008214 protein dealkylation GO:0016570 histone modification GO:0016577 histone demethylation GO:0070076 histone lysine demethylation GO:0070544 histone H3-K36 demethylation GO:0070988 demethylation
Molecular Function	GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors GO:0032451 demethylase activity GO:0032452 histone demethylase activity GO:0051213 dioxygenase activity GO:0051864 histone demethylase activity (H3-K36 specific)
Cellular Component	-

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-3214842: HDMs demethylate histones

Summary
Symbol	KDM2A
Name	lysine demethylase 2A
Aliases	KIAA1004; FBL11; LILINA; DKFZP434M1735; FLJ00115; CXXC8; JHDM1A; F-box protein FBL11; jumonji C domain-conta ......
Location	11q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM1255482	c.3136C>T	p.L1046L	Substitution - coding silent	Oesophagus
COSM4756781	c.2528G>A	p.R843Q	Substitution - Missense	Stomach
COSM1255481	c.438C>A	p.L146L	Substitution - coding silent	Oesophagus
COSM931018	c.1715G>A	p.R572Q	Substitution - Missense	Endometrium
COSM5051076	c.1971C>T	p.D657D	Substitution - coding silent	Stomach
COSM5373359	c.2495C>T	p.S832F	Substitution - Missense	Skin
COSM5714759	c.3217C>T	p.H1073Y	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3452250	c.1714C>T	p.R572*	Substitution - Nonsense	Skin
COSM3935597	c.3420C>T	p.F1140F	Substitution - coding silent	Oesophagus
COSM4590278	c.310A>G	p.S104G	Substitution - Missense	Soft_tissue
COSM4035920	c.3047A>G	p.D1016G	Substitution - Missense	Stomach
COSM4511002	c.854C>T	p.A285V	Substitution - Missense	Skin
COSM2041366	c.1704A>G	p.R568R	Substitution - coding silent	Large_intestine
COSM3810194	c.828C>T	p.F276F	Substitution - coding silent	Pancreas
COSM1171829	c.3423C>G	p.I1141M	Substitution - Missense	Oesophagus
COSM95881	c.3126C>G	p.T1042T	Substitution - coding silent	Breast
COSM4590278	c.310A>G	p.S104G	Substitution - Missense	Soft_tissue
COSM5368588	c.1021G>C	p.V341L	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3452251	c.2819C>T	p.A940V	Substitution - Missense	Skin
COSM5962502	c.1669G>A	p.A557T	Substitution - Missense	Breast
COSM4165923	c.644T>C	p.F215S	Substitution - Missense	Kidney
COSM1628186	c.1702C>T	p.R568*	Substitution - Nonsense	Liver
COSM5373357	c.1371G>A	p.E457E	Substitution - coding silent	Skin
COSM3791853	c.3052C>G	p.Q1018E	Substitution - Missense	Urinary_tract
COSM5475562	c.1681G>A	p.V561M	Substitution - Missense	Large_intestine
COSM3368524	c.1607C>T	p.P536L	Substitution - Missense	Thyroid
COSM4035912	c.1300C>T	p.H434Y	Substitution - Missense	Stomach
COSM270707	c.2379G>T	p.K793N	Substitution - Missense	Large_intestine
COSM4694877	c.3202C>T	p.R1068*	Substitution - Nonsense	Large_intestine
COSM4823312	c.1065G>C	p.Q355H	Substitution - Missense	Cervix
COSM2041406	c.2723G>A	p.R908K	Substitution - Missense	Upper_aerodigestive_tract
COSM1192971	c.729delG	p.Y244fs*50	Deletion - Frameshift	Lung
COSM5753786	c.1900G>C	p.D634H	Substitution - Missense	Large_intestine
COSM4035919	c.2981C>T	p.A994V	Substitution - Missense	Stomach
COSM4983396	c.1614G>A	p.T538T	Substitution - coding silent	Oesophagus
COSM5051074	c.43C>T	p.R15C	Substitution - Missense	Stomach
COSM77940	c.667C>T	p.H223Y	Substitution - Missense	Ovary
COSM1628186	c.1702C>T	p.R568*	Substitution - Nonsense	Liver
COSM5831837	c.2531delC	p.Q846fs*33	Deletion - Frameshift	Breast
COSM4508820	c.788C>G	p.S263*	Substitution - Nonsense	Skin
COSM4819096	c.2238C>G	p.S746R	Substitution - Missense	Cervix
COSM4146183	c.599G>C	p.C200S	Substitution - Missense	Thyroid
COSM4694874	c.2287C>T	p.L763L	Substitution - coding silent	Large_intestine
COSM4590278	c.310A>G	p.S104G	Substitution - Missense	Upper_aerodigestive_tract
COSM2041354	c.1244C>T	p.P415L	Substitution - Missense	Large_intestine
COSM4035921	c.3293A>G	p.E1098G	Substitution - Missense	Stomach
COSM3666979	c.686A>C	p.K229T	Substitution - Missense	Liver
COSM2041390	c.2406G>T	p.T802T	Substitution - coding silent	Upper_aerodigestive_tract
COSM4851897	c.3203G>A	p.R1068Q	Substitution - Missense	Cervix
COSM1356354	c.894delT	p.L300fs*10	Deletion - Frameshift	Large_intestine
COSM4590278	c.310A>G	p.S104G	Substitution - Missense	Upper_aerodigestive_tract
COSM4574708	c.3021_3025delTCTTC	p.D1007fs*20	Deletion - Frameshift	Bone
COSM3788037	c.1270G>T	p.D424Y	Substitution - Missense	Pancreas
COSM931009	c.28T>C	p.Y10H	Substitution - Missense	Endometrium
COSM931016	c.990T>C	p.Y330Y	Substitution - coding silent	Endometrium
COSM213566	c.1582C>T	p.P528S	Substitution - Missense	Breast
COSM429693	c.3307+2T>G	p.?	Unknown	Oesophagus
COSM2041419	c.3192C>G	p.P1064P	Substitution - coding silent	Oesophagus
COSM94274	c.2206G>C	p.V736L	Substitution - Missense	Lung
COSM4602837	c.3487T>G	p.*1163E	Nonstop extension	Upper_aerodigestive_tract
COSM3687789	c.2462C>T	p.A821V	Substitution - Missense	Large_intestine
COSM931017	c.1552A>C	p.K518Q	Substitution - Missense	Endometrium
COSM4884759	c.2631G>T	p.R877S	Substitution - Missense	Upper_aerodigestive_tract
COSM4590278	c.310A>G	p.S104G	Substitution - Missense	Upper_aerodigestive_tract
COSM5811971	c.1377A>C	p.E459D	Substitution - Missense	Liver
COSM3869979	c.3445C>T	p.L1149F	Substitution - Missense	Skin
COSM5567213	c.312T>G	p.S104R	Substitution - Missense	Prostate
COSM347808	c.2715C>G	p.L905L	Substitution - coding silent	Lung
COSM1475800	c.1063C>T	p.Q355*	Substitution - Nonsense	Breast
COSM4590278	c.310A>G	p.S104G	Substitution - Missense	Upper_aerodigestive_tract
COSM6014529	c.2477C>T	p.S826F	Substitution - Missense	Skin
COSM4598052	c.1282G>A	p.D428N	Substitution - Missense	Upper_aerodigestive_tract
COSM5821644	c.1057G>T	p.E353*	Substitution - Nonsense	Liver
COSM4590278	c.310A>G	p.S104G	Substitution - Missense	Upper_aerodigestive_tract
COSM4506490	c.721C>T	p.L241L	Substitution - coding silent	Skin
COSM4590278	c.310A>G	p.S104G	Substitution - Missense	Upper_aerodigestive_tract
COSM690384	c.46G>T	p.G16C	Substitution - Missense	Lung
COSM4590278	c.310A>G	p.S104G	Substitution - Missense	Upper_aerodigestive_tract
COSM4590278	c.310A>G	p.S104G	Substitution - Missense	Upper_aerodigestive_tract
COSM4848397	c.474G>A	p.Q158Q	Substitution - coding silent	Cervix
COSM931012	c.350A>C	p.K117T	Substitution - Missense	Endometrium
COSM1628186	c.1702C>T	p.R568*	Substitution - Nonsense	Large_intestine
COSM5891440	c.190G>T	p.V64L	Substitution - Missense	Skin
COSM3687567	c.485C>T	p.T162M	Substitution - Missense	Large_intestine
COSM4694871	c.158T>G	p.F53C	Substitution - Missense	Large_intestine
COSM4395807	c.1169C>T	p.S390F	Substitution - Missense	Skin
COSM4590278	c.310A>G	p.S104G	Substitution - Missense	Upper_aerodigestive_tract
COSM1356364	c.3133C>T	p.R1045W	Substitution - Missense	Large_intestine
COSM467300	c.2405C>T	p.T802M	Substitution - Missense	Kidney
COSM1171829	c.3423C>G	p.I1141M	Substitution - Missense	Breast
COSM931022	c.3401G>A	p.R1134Q	Substitution - Missense	Endometrium
COSM3810195	c.1318G>A	p.D440N	Substitution - Missense	Breast
COSM3810194	c.828C>T	p.F276F	Substitution - coding silent	Breast
COSM4928810	c.938A>G	p.N313S	Substitution - Missense	Liver
COSM5517161	c.2933-10T>A	p.?	Unknown	Biliary_tract
COSM4590278	c.310A>G	p.S104G	Substitution - Missense	Upper_aerodigestive_tract
COSM4590278	c.310A>G	p.S104G	Substitution - Missense	Upper_aerodigestive_tract
COSM5733012	c.3443_3444insGCCTCTACT	p.S1148>RPLL	Complex - insertion inframe	Pancreas
COSM3810196	c.1576A>C	p.T526P	Substitution - Missense	Breast
COSM3869978	c.2390C>T	p.S797L	Substitution - Missense	Skin
COSM95880	c.3009C>G	p.L1003L	Substitution - coding silent	Lung
COSM2041346	c.800G>A	p.R267H	Substitution - Missense	Large_intestine
COSM5482413	c.2280G>T	p.R760R	Substitution - coding silent	Large_intestine
COSM5437049	c.438C>T	p.L146L	Substitution - coding silent	Oesophagus
COSM4775899	c.72T>C	p.D24D	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM1298488	c.3369G>A	p.L1123L	Substitution - coding silent	Urinary_tract
COSM931021	c.2259C>T	p.R753R	Substitution - coding silent	Endometrium
COSM1356359	c.2198G>A	p.R733Q	Substitution - Missense	Large_intestine
COSM4951669	c.2125G>T	p.D709Y	Substitution - Missense	Liver
COSM931013	c.611T>C	p.V204A	Substitution - Missense	Endometrium
COSM3666979	c.686A>C	p.K229T	Substitution - Missense	Liver
COSM415789	c.2320C>T	p.R774W	Substitution - Missense	Urinary_tract
COSM4796801	c.1564-1G>A	p.?	Unknown	Liver
COSM5373360	c.2951T>A	p.L984Q	Substitution - Missense	Skin
COSM415788	c.3058C>T	p.R1020W	Substitution - Missense	Endometrium
COSM2041395	c.2500C>A	p.R834S	Substitution - Missense	Large_intestine
COSM6014530	c.3436A>G	p.I1146V	Substitution - Missense	Skin
COSM5674055	c.59G>T	p.R20L	Substitution - Missense	Soft_tissue
COSM415788	c.3058C>T	p.R1020W	Substitution - Missense	Large_intestine
COSM3452247	c.215T>A	p.L72*	Substitution - Nonsense	Skin
COSM4590278	c.310A>G	p.S104G	Substitution - Missense	Soft_tissue
COSM4413455	c.1822C>T	p.Q608*	Substitution - Nonsense	Genital_tract
COSM4590278	c.310A>G	p.S104G	Substitution - Missense	Upper_aerodigestive_tract
COSM117772	c.2380A>C	p.I794L	Substitution - Missense	Ovary
COSM415788	c.3058C>T	p.R1020W	Substitution - Missense	Urinary_tract
COSM1492690	c.1469C>T	p.A490V	Substitution - Missense	Kidney
COSM2041370	c.1887T>C	p.N629N	Substitution - coding silent	Large_intestine
COSM329439	c.2239G>A	p.D747N	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4590278	c.310A>G	p.S104G	Substitution - Missense	Soft_tissue
COSM1239207	c.267G>A	p.P89P	Substitution - coding silent	Oesophagus
COSM5095369	c.3225C>A	p.S1075R	Substitution - Missense	Thymus
COSM4035922	c.3298A>G	p.N1100D	Substitution - Missense	Stomach
COSM4590278	c.310A>G	p.S104G	Substitution - Missense	Soft_tissue
COSM5668989	c.3278G>C	p.R1093P	Substitution - Missense	Soft_tissue
COSM1605105	c.2416C>T	p.P806S	Substitution - Missense	Liver
COSM2041353	c.1158C>T	p.S386S	Substitution - coding silent	Large_intestine
COSM4168379	c.2578_2579insGGG	p.E859_E860insG	Insertion - In frame	Peritoneum
COSM1356361	c.2559delG	p.G855fs*24	Deletion - Frameshift	Large_intestine
COSM3670872	c.2455C>A	p.L819M	Substitution - Missense	Prostate
COSM931010	c.62G>A	p.R21H	Substitution - Missense	Endometrium
COSM77941	c.2879G>A	p.S960N	Substitution - Missense	Ovary
COSM931019	c.1725A>C	p.K575N	Substitution - Missense	Endometrium
COSM4926981	c.1376A>G	p.E459G	Substitution - Missense	Liver
COSM25630	c.3014C>T	p.T1005I	Substitution - Missense	Skin
COSM4796801	c.1564-1G>A	p.?	Unknown	Liver
COSM4035917	c.2681A>G	p.Q894R	Substitution - Missense	Stomach
COSM5051075	c.1303A>G	p.N435D	Substitution - Missense	Stomach
COSM4590278	c.310A>G	p.S104G	Substitution - Missense	Soft_tissue
COSM5051077	c.2683C>T	p.R895W	Substitution - Missense	Stomach
COSM5980139	c.2212C>T	p.R738W	Substitution - Missense	Upper_aerodigestive_tract
COSM5753787	c.2035G>A	p.D679N	Substitution - Missense	Large_intestine
COSM4694875	c.2501G>T	p.R834L	Substitution - Missense	Large_intestine
COSM931020	c.2104C>A	p.L702M	Substitution - Missense	Endometrium
COSM3452249	c.1674C>T	p.S558S	Substitution - coding silent	Skin
COSM2041403	c.2578_2580delGAG	p.E866delE	Deletion - In frame	Upper_aerodigestive_tract
COSM415788	c.3058C>T	p.R1020W	Substitution - Missense	Endometrium
COSM4413456	c.2651G>T	p.W884L	Substitution - Missense	Genital_tract
COSM4590278	c.310A>G	p.S104G	Substitution - Missense	Upper_aerodigestive_tract
COSM5373358	c.2166G>A	p.M722I	Substitution - Missense	Skin
COSM4478196	c.2219C>T	p.S740F	Substitution - Missense	Skin
COSM4590278	c.310A>G	p.S104G	Substitution - Missense	Upper_aerodigestive_tract
COSM4590278	c.310A>G	p.S104G	Substitution - Missense	Upper_aerodigestive_tract
COSM5603863	c.2339C>T	p.P780L	Substitution - Missense	Skin
COSM931011	c.70G>T	p.D24Y	Substitution - Missense	Endometrium
COSM1322224	c.3208G>A	p.D1070N	Substitution - Missense	Ovary
COSM5462071	c.594-2A>G	p.?	Unknown	Large_intestine
COSM3810193	c.59G>A	p.R20Q	Substitution - Missense	Breast
COSM4823285	c.1155G>C	p.L385F	Substitution - Missense	Cervix
COSM94275	c.2334C>A	p.N778K	Substitution - Missense	Lung
COSM3810197	c.1603A>G	p.I535V	Substitution - Missense	Breast
COSM2041333	c.324G>A	p.V108V	Substitution - coding silent	Bone
COSM3359358	c.3216T>G	p.S1072R	Substitution - Missense	Kidney
COSM1255481	c.438C>A	p.L146L	Substitution - coding silent	Liver
COSM3452248	c.1109C>T	p.S370F	Substitution - Missense	Skin
COSM3953703	c.1396G>A	p.D466N	Substitution - Missense	Lung
COSM5373356	c.402G>A	p.E134E	Substitution - coding silent	Skin
COSM4035918	c.2707C>T	p.R903C	Substitution - Missense	Stomach
COSM4165924	c.2002A>C	p.N668H	Substitution - Missense	Kidney
COSM4694876	c.3181C>T	p.R1061C	Substitution - Missense	Oesophagus
COSM5739345	c.1865T>C	p.L622P	Substitution - Missense	Small_intestine
COSM1356357	c.1905T>C	p.F635F	Substitution - coding silent	Large_intestine
COSM2041411	c.2916C>T	p.L972L	Substitution - coding silent	Large_intestine
COSM1475802	c.1307G>A	p.G436E	Substitution - Missense	Breast
COSM4778743	c.2570A>T	p.E857V	Substitution - Missense	Liver
COSM4590278	c.310A>G	p.S104G	Substitution - Missense	Upper_aerodigestive_tract
COSM3676281	c.2130G>C	p.E710D	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM931022	c.3401G>A	p.R1134Q	Substitution - Missense	Kidney
COSM5970320	c.2044G>A	p.E682K	Substitution - Missense	Upper_aerodigestive_tract
COSM4165922	c.594-5G>A	p.?	Unknown	Kidney
COSM690383	c.662G>T	p.W221L	Substitution - Missense	Lung
COSM4694873	c.1619C>T	p.P540L	Substitution - Missense	Large_intestine
COSM429691	c.1480-1G>T	p.?	Unknown	Breast
COSM75102	c.3349C>T	p.R1117C	Substitution - Missense	Ovary
COSM931014	c.713C>T	p.A238V	Substitution - Missense	Endometrium
COSM4590278	c.310A>G	p.S104G	Substitution - Missense	Biliary_tract
COSM3967777	c.1696C>T	p.R566W	Substitution - Missense	Central_nervous_system
COSM2041368	c.1782T>C	p.F594F	Substitution - coding silent	Large_intestine
COSM4565873	c.2642_2643GG>AA	p.R881Q	Substitution - Missense	Skin
COSM1356364	c.3133C>T	p.R1045W	Substitution - Missense	Large_intestine
COSM4590278	c.310A>G	p.S104G	Substitution - Missense	Upper_aerodigestive_tract
COSM2041380	c.2192C>T	p.S731F	Substitution - Missense	Skin
COSM266751	c.410G>A	p.R137Q	Substitution - Missense	Large_intestine
COSM429692	c.2987G>A	p.S996N	Substitution - Missense	Breast
COSM4639778	c.1926C>T	p.C642C	Substitution - coding silent	Large_intestine
COSM5627435	c.10G>A	p.E4K	Substitution - Missense	Oesophagus
COSM1356352	c.443T>G	p.F148C	Substitution - Missense	Large_intestine
COSM4590278	c.310A>G	p.S104G	Substitution - Missense	Soft_tissue
COSM2041354	c.1244C>T	p.P415L	Substitution - Missense	Large_intestine
COSM4590278	c.310A>G	p.S104G	Substitution - Missense	Soft_tissue
COSM4613273	c.2616delG	p.G874fs*5	Deletion - Frameshift	Large_intestine
COSM4035923	c.3352A>G	p.I1118V	Substitution - Missense	Stomach
COSM94276	c.2501G>A	p.R834H	Substitution - Missense	Ovary
COSM4970858	c.2386G>A	p.G796R	Substitution - Missense	Central_nervous_system
COSM1605105	c.2416C>T	p.P806S	Substitution - Missense	Liver
COSM4854509	c.3477G>A	p.Q1159Q	Substitution - coding silent	Cervix
COSM4694876	c.3181C>T	p.R1061C	Substitution - Missense	Large_intestine
COSM4590278	c.310A>G	p.S104G	Substitution - Missense	Upper_aerodigestive_tract
COSM4590278	c.310A>G	p.S104G	Substitution - Missense	Upper_aerodigestive_tract
COSM4855895	c.3297C>A	p.L1099L	Substitution - coding silent	Cervix
COSM4035914	c.2250T>C	p.S750S	Substitution - coding silent	Stomach
COSM5899033	c.242C>T	p.S81F	Substitution - Missense	Skin
COSM931015	c.984C>T	p.F328F	Substitution - coding silent	Endometrium
COSM4395199	c.2869C>T	p.L957F	Substitution - Missense	Skin
COSM329440	c.2124C>T	p.C708C	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM5811451	c.49A>G	p.T17A	Substitution - Missense	Liver
COSM5999734	c.2607T>C	p.S869S	Substitution - coding silent	Prostate
COSM3687568	c.1079G>A	p.S360N	Substitution - Missense	Large_intestine
COSM4911605	c.571A>T	p.M191L	Substitution - Missense	Liver
COSM690379	c.2258G>A	p.R753H	Substitution - Missense	Lung
COSM3359357	c.2208G>A	p.V736V	Substitution - coding silent	Kidney
COSM2041370	c.1887T>C	p.N629N	Substitution - coding silent	Large_intestine
COSM4590278	c.310A>G	p.S104G	Substitution - Missense	Upper_aerodigestive_tract
COSM1743611	c.1144C>G	p.P382A	Substitution - Missense	Biliary_tract
COSM5764947	c.1993G>T	p.E665*	Substitution - Nonsense	Large_intestine
COSM5920138	c.2488C>T	p.R830C	Substitution - Missense	Skin
COSM3383761	c.307+1G>T	p.?	Unknown	Pancreas
COSM295027	c.2422A>G	p.K808E	Substitution - Missense	Large_intestine
COSM1356360	c.2495delC	p.R834fs*3	Deletion - Frameshift	Large_intestine
COSM4694872	c.1384C>T	p.R462C	Substitution - Missense	Large_intestine
COSM690381	c.1016G>A	p.R339H	Substitution - Missense	Lung
COSM3769421	c.2365G>T	p.V789F	Substitution - Missense	Pancreas
COSM4838290	c.373C>T	p.Q125*	Substitution - Nonsense	Cervix
COSM5633011	c.3401G>C	p.R1134P	Substitution - Missense	Oesophagus
COSM2041402	c.2577A>G	p.E859E	Substitution - coding silent	Stomach
COSM4035915	c.2388A>T	p.G796G	Substitution - coding silent	Stomach
COSM4590278	c.310A>G	p.S104G	Substitution - Missense	Upper_aerodigestive_tract
COSM1356361	c.2559delG	p.G855fs*24	Deletion - Frameshift	Large_intestine
COSM4928639	c.444T>A	p.F148L	Substitution - Missense	Liver
COSM1356360	c.2495delC	p.R834fs*3	Deletion - Frameshift	Breast
COSM3670871	c.1409C>A	p.S470Y	Substitution - Missense	Prostate
COSM4951669	c.2125G>T	p.D709Y	Substitution - Missense	Liver
COSM5704150	c.496A>G	p.I166V	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4035913	c.1480A>G	p.I494V	Substitution - Missense	Stomach
COSM4035916	c.2667C>T	p.D889D	Substitution - coding silent	Stomach

> Text Mining based Variations [ TOP ]
There is no record for KDM2A.

Summary
Symbol	KDM2A
Name	lysine demethylase 2A
Aliases	KIAA1004; FBL11; LILINA; DKFZP434M1735; FLJ00115; CXXC8; JHDM1A; F-box protein FBL11; jumonji C domain-conta ......
Location	11q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

[ TOP ]

Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
Q9Y2K7	390	S	Phosphoserine	-	No	None detected
Q9Y2K7	394	S	Phosphoserine	-	No	None detected
Q9Y2K7	550	T	Phosphothreonine	-	No	None detected
Q9Y2K7	558	S	Phosphoserine	-	No	None detected
Q9Y2K7	632	T	Phosphothreonine	-	No	None detected
Q9Y2K7	692	S	Phosphoserine	-	No	None detected
Q9Y2K7	713	T	Phosphothreonine	-	No	None detected
Q9Y2K7	718	S	Phosphoserine	-	No	None detected
Q9Y2K7	731	S	Phosphoserine	-	Yes	p.S731fs (cancer: COAD)
Q9Y2K7	825	S	Phosphoserine	-	No	None detected
Q9Y2K7	832	S	Phosphoserine	-	Yes	p.S832fs (cancer: BRCA, COAD)
Q9Y2K7	869	S	Phosphoserine	-	No	None detected
Q9Y2K7	883	S	Phosphoserine	-	No	None detected

Summary
Symbol	KDM2A
Name	lysine demethylase 2A
Aliases	KIAA1004; FBL11; LILINA; DKFZP434M1735; FLJ00115; CXXC8; JHDM1A; F-box protein FBL11; jumonji C domain-conta ......
Location	11q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	7.384	7.273	-0.1	0.464	NS
BRCA	Breast invasive carcinoma	112	1100	7.418	7.528	0.172	0.00104	NS
CESC	Cervical and endocervical cancers	3	306	6.996	7.428	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	6.972	6.894	-0.065	0.403	NS
ESCA	Esophageal carcinoma	11	185	7.463	7.721	0.169	0.398	NS
GBM	Glioblastoma multiforme	5	166	6.613	6.268	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	7.323	7.463	0.202	0.0253	NS
KIRC	Kidney renal clear cell carcinoma	72	534	6.838	7.063	0.212	1.01e-06	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	6.865	6.723	-0.124	0.118	NS
LAML	Acute Myeloid Leukemia	0	173	NA	8.345	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	6.439	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	6.174	6.245	0.09	0.258	NS
LUAD	Lung adenocarcinoma	59	517	7.172	7.441	0.311	8.92e-06	NS
LUSC	Lung squamous cell carcinoma	51	501	7.219	7.385	0.183	0.0284	NS
OV	Ovarian serous cystadenocarcinoma	0	307	NA	7.863	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	6.983	7.087	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	6.533	6.566	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	6.933	6.847	-0.035	0.534	NS
READ	Rectum adenocarcinoma	10	167	6.887	6.909	0.138	0.459	NS
SARC	Sarcoma	2	263	6.419	6.921	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	6.948	6.832	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	7.151	7.358	0.189	0.0709	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	7.082	NA	NA	NA
THCA	Thyroid carcinoma	59	509	7.097	7.138	0.003	0.937	NS
THYM	Thymoma	2	120	7.8	7.207	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	7.053	7.146	0.158	0.058	NS

> Cancer Cell Line Encyclopedia (CCLE)

[ TOP ]

Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	7.2
Autonomic ganglia	CHP212	7.6
Autonomic ganglia	IMR32	7.7
Autonomic ganglia	KELLY	7.3
Autonomic ganglia	KPNRTBM1	7.5
Autonomic ganglia	KPNSI9S	6.8
Autonomic ganglia	KPNYN	7.5
Autonomic ganglia	MHHNB11	7
Autonomic ganglia	NB1	7.6
Autonomic ganglia	NH6	7.3
Autonomic ganglia	SHSY5Y	7
Autonomic ganglia	SIMA	7
Autonomic ganglia	SKNAS	7.5
Autonomic ganglia	SKNBE2	7.9
Autonomic ganglia	SKNDZ	7.3
Autonomic ganglia	SKNFI	7.4
Autonomic ganglia	SKNSH	6.7
Biliary tract	HUCCT1	7.9
Biliary tract	HUH28	7.6
Biliary tract	SNU1079	6.5
Biliary tract	SNU1196	8.7
Biliary tract	SNU245	7.7
Biliary tract	SNU308	7.9
Biliary tract	SNU478	8.3
Bone	143B	8.3
Bone	A673	8.4
Bone	CADOES1	7
Bone	CAL78	7.4
Bone	G292CLONEA141B1	8.4
Bone	HOS	9
Bone	HS706T	7.3
Bone	HS737T	7.4
Bone	HS819T	7.6
Bone	HS821T	7.5
Bone	HS822T	7.5
Bone	HS863T	7.4
Bone	HS870T	7
Bone	HS888T	7.6
Bone	MG63	7.6
Bone	MHHES1	8.6
Bone	OUMS27	7.7
Bone	RDES	9
Bone	SJSA1	8
Bone	SKES1	7.6
Bone	SKNMC	8.5
Bone	SW1353	7.6
Bone	T173	7.3
Bone	TC71	7.7
Bone	U2OS	7.3
Breast	AU565	8.4
Breast	BT20	8.1
Breast	BT474	9.3
Breast	BT483	8.4
Breast	BT549	7.9
Breast	CAL120	7.7
Breast	CAL148	8.3
Breast	CAL51	7.9
Breast	CAL851	8.1
Breast	CAMA1	8.7
Breast	DU4475	7.2
Breast	EFM192A	7.7
Breast	EFM19	8.7
Breast	EVSAT	8.6
Breast	HCC1143	8.2
Breast	HCC1187	8.9
Breast	HCC1395	8.4
Breast	HCC1419	9.7
Breast	HCC1428	8.8
Breast	HCC1500	8.1
Breast	HCC1569	8.4
Breast	HCC1599	7.5
Breast	HCC1806	8.6
Breast	HCC1937	9.1
Breast	HCC1954	7.7
Breast	HCC202	8.2
Breast	HCC2157	8.5
Breast	HCC2218	8.1
Breast	HCC38	8.7
Breast	HCC70	7.9
Breast	HDQP1	9.7
Breast	HMC18	7.7
Breast	HS274T	7.4
Breast	HS281T	7.6
Breast	HS343T	7.6
Breast	HS578T	7.8
Breast	HS606T	7.5
Breast	HS739T	7.4
Breast	HS742T	7.3
Breast	JIMT1	8.5
Breast	KPL1	8.4
Breast	MCF7	8.5
Breast	MDAMB134VI	8.8
Breast	MDAMB157	7
Breast	MDAMB175VII	8.7
Breast	MDAMB231	8.1
Breast	MDAMB361	8.3
Breast	MDAMB415	10.7
Breast	MDAMB436	8.2
Breast	MDAMB453	8.8
Breast	MDAMB468	8.1
Breast	SKBR3	8.6
Breast	T47D	8.7
Breast	UACC812	9.1
Breast	UACC893	8.4
Breast	YMB1	9.5
Breast	ZR751	9.1
Breast	ZR7530	8.6
Central nervous system	1321N1	7.2
Central nervous system	42MGBA	7.7
Central nervous system	8MGBA	8
Central nervous system	A172	7.4
Central nervous system	AM38	6.9
Central nervous system	BECKER	7.8
Central nervous system	CAS1	7.2
Central nervous system	CCFSTTG1	7.7
Central nervous system	D283MED	7.8
Central nervous system	D341MED	7.4
Central nervous system	DAOY	7.3
Central nervous system	DBTRG05MG	7.2
Central nervous system	DKMG	7.2
Central nervous system	GAMG	7.2
Central nervous system	GB1	7.6
Central nervous system	GI1	8
Central nervous system	GMS10	7.3
Central nervous system	GOS3	7.6
Central nervous system	H4	7.6
Central nervous system	HS683	7.6
Central nervous system	KALS1	7.2
Central nervous system	KG1C	7.1
Central nervous system	KNS42	7.6
Central nervous system	KNS60	7
Central nervous system	KNS81	7.2
Central nervous system	KS1	6.9
Central nervous system	LN18	7.6
Central nervous system	LN229	7.3
Central nervous system	M059K	7.2
Central nervous system	MOGGCCM	7.3
Central nervous system	MOGGUVW	7.1
Central nervous system	NMCG1	6.8
Central nervous system	ONS76	7.5
Central nervous system	SF126	7.2
Central nervous system	SF295	7.1
Central nervous system	SNB19	7.2
Central nervous system	SNU1105	7.2
Central nervous system	SNU201	7.5
Central nervous system	SNU466	7.5
Central nervous system	SNU489	7.5
Central nervous system	SNU626	7.1
Central nervous system	SNU738	7.3
Central nervous system	SW1088	7.2
Central nervous system	SW1783	7.2
Central nervous system	T98G	7.9
Central nervous system	TM31	8.2
Central nervous system	U118MG	7.4
Central nervous system	U138MG	7.5
Central nervous system	U251MG	7.3
Central nervous system	U87MG	7.2
Central nervous system	YH13	7.6
Central nervous system	YKG1	7.2
Endometrium	AN3CA	8.1
Endometrium	COLO684	7.4
Endometrium	EFE184	7.3
Endometrium	EN	7.7
Endometrium	ESS1	7.7
Endometrium	HEC108	7.4
Endometrium	HEC151	7.8
Endometrium	HEC1A	7.5
Endometrium	HEC1B	8
Endometrium	HEC251	7.3
Endometrium	HEC265	7.9
Endometrium	HEC50B	7.5
Endometrium	HEC59	8.3
Endometrium	HEC6	7.6
Endometrium	ISHIKAWAHERAKLIO02ER	7.7
Endometrium	JHUEM1	8.3
Endometrium	JHUEM2	7.9
Endometrium	JHUEM3	7.3
Endometrium	KLE	7.1
Endometrium	MFE280	7.6
Endometrium	MFE296	7.7
Endometrium	MFE319	7.8
Endometrium	RL952	8.2
Endometrium	SNGM	7.5
Endometrium	SNU1077	8.5
Endometrium	SNU685	7.9
Endometrium	TEN	8.2
Haematopoietic and lymphoid	697	8.1
Haematopoietic and lymphoid	A3KAW	7.3
Haematopoietic and lymphoid	A4FUK	8
Haematopoietic and lymphoid	ALLSIL	8.1
Haematopoietic and lymphoid	AML193	8.3
Haematopoietic and lymphoid	AMO1	7.7
Haematopoietic and lymphoid	BCP1	8.2
Haematopoietic and lymphoid	BDCM	7.6
Haematopoietic and lymphoid	BL41	7.9
Haematopoietic and lymphoid	BL70	8
Haematopoietic and lymphoid	BV173	8
Haematopoietic and lymphoid	CA46	7.8
Haematopoietic and lymphoid	CI1	7.9
Haematopoietic and lymphoid	CMK115	8.3
Haematopoietic and lymphoid	CMK86	8.2
Haematopoietic and lymphoid	CMK	8.2
Haematopoietic and lymphoid	CMLT1	7.8
Haematopoietic and lymphoid	COLO775	8.1
Haematopoietic and lymphoid	DAUDI	7.7
Haematopoietic and lymphoid	DB	8.3
Haematopoietic and lymphoid	DEL	7.7
Haematopoietic and lymphoid	DND41	8.3
Haematopoietic and lymphoid	DOHH2	7.9
Haematopoietic and lymphoid	EB1	8.1
Haematopoietic and lymphoid	EB2	8.2
Haematopoietic and lymphoid	EHEB	8.1
Haematopoietic and lymphoid	EJM	8.7
Haematopoietic and lymphoid	EM2	8.1
Haematopoietic and lymphoid	EOL1	8.4
Haematopoietic and lymphoid	F36P	7.6
Haematopoietic and lymphoid	GA10	7.7
Haematopoietic and lymphoid	GDM1	7.6
Haematopoietic and lymphoid	GRANTA519	7.9
Haematopoietic and lymphoid	HDLM2	8.6
Haematopoietic and lymphoid	HDMYZ	6.9
Haematopoietic and lymphoid	HEL9217	7.3
Haematopoietic and lymphoid	HEL	7.3
Haematopoietic and lymphoid	HH	7.8
Haematopoietic and lymphoid	HL60	8.9
Haematopoietic and lymphoid	HPBALL	8.3
Haematopoietic and lymphoid	HS604T	7.4
Haematopoietic and lymphoid	HS611T	7.6
Haematopoietic and lymphoid	HS616T	7.4
Haematopoietic and lymphoid	HS751T	7
Haematopoietic and lymphoid	HT	8.4
Haematopoietic and lymphoid	HTK	7.8
Haematopoietic and lymphoid	HUNS1	7.3
Haematopoietic and lymphoid	HUT102	8.2
Haematopoietic and lymphoid	HUT78	8.6
Haematopoietic and lymphoid	JEKO1	8.3
Haematopoietic and lymphoid	JK1	7.9
Haematopoietic and lymphoid	JM1	7.8
Haematopoietic and lymphoid	JURKAT	7.6
Haematopoietic and lymphoid	JURLMK1	7.8
Haematopoietic and lymphoid	JVM2	7.9
Haematopoietic and lymphoid	JVM3	8.6
Haematopoietic and lymphoid	K562	7.1
Haematopoietic and lymphoid	KARPAS299	8.2
Haematopoietic and lymphoid	KARPAS422	8.3
Haematopoietic and lymphoid	KARPAS620	8.8
Haematopoietic and lymphoid	KASUMI1	8.2
Haematopoietic and lymphoid	KASUMI2	8.4
Haematopoietic and lymphoid	KASUMI6	7.6
Haematopoietic and lymphoid	KCL22	7.5
Haematopoietic and lymphoid	KE37	7.7
Haematopoietic and lymphoid	KE97	7.4
Haematopoietic and lymphoid	KG1	8.6
Haematopoietic and lymphoid	KHM1B	8.6
Haematopoietic and lymphoid	KIJK	7.7
Haematopoietic and lymphoid	KMH2	7.5
Haematopoietic and lymphoid	KMM1	8.4
Haematopoietic and lymphoid	KMS11	8.4
Haematopoietic and lymphoid	KMS12BM	8.6
Haematopoietic and lymphoid	KMS18	7.7
Haematopoietic and lymphoid	KMS20	7.9
Haematopoietic and lymphoid	KMS21BM	8.3
Haematopoietic and lymphoid	KMS26	7.7
Haematopoietic and lymphoid	KMS27	8.8
Haematopoietic and lymphoid	KMS28BM	8
Haematopoietic and lymphoid	KMS34	7.8
Haematopoietic and lymphoid	KO52	8.1
Haematopoietic and lymphoid	KOPN8	8.2
Haematopoietic and lymphoid	KU812	8.6
Haematopoietic and lymphoid	KYO1	7.7
Haematopoietic and lymphoid	L1236	7.4
Haematopoietic and lymphoid	L363	8.7
Haematopoietic and lymphoid	L428	8
Haematopoietic and lymphoid	L540	8.4
Haematopoietic and lymphoid	LAMA84	8.2
Haematopoietic and lymphoid	LOUCY	8.4
Haematopoietic and lymphoid	LP1	8
Haematopoietic and lymphoid	M07E	8
Haematopoietic and lymphoid	MC116	7.9
Haematopoietic and lymphoid	ME1	8.8
Haematopoietic and lymphoid	MEC1	7.7
Haematopoietic and lymphoid	MEC2	8.4
Haematopoietic and lymphoid	MEG01	7.5
Haematopoietic and lymphoid	MHHCALL2	8.5
Haematopoietic and lymphoid	MHHCALL3	8.6
Haematopoietic and lymphoid	MHHCALL4	8.4
Haematopoietic and lymphoid	MINO	8.1
Haematopoietic and lymphoid	MJ	8.2
Haematopoietic and lymphoid	MM1S	8.8
Haematopoietic and lymphoid	MOLM13	8.1
Haematopoietic and lymphoid	MOLM16	8.4
Haematopoietic and lymphoid	MOLM6	8
Haematopoietic and lymphoid	MOLP2	8.9
Haematopoietic and lymphoid	MOLP8	8.1
Haematopoietic and lymphoid	MOLT13	7.9
Haematopoietic and lymphoid	MOLT16	7.9
Haematopoietic and lymphoid	MOLT4	7.7
Haematopoietic and lymphoid	MONOMAC1	8.3
Haematopoietic and lymphoid	MONOMAC6	8.1
Haematopoietic and lymphoid	MOTN1	8.6
Haematopoietic and lymphoid	MUTZ5	8.4
Haematopoietic and lymphoid	MV411	8.4
Haematopoietic and lymphoid	NALM19	8.1
Haematopoietic and lymphoid	NALM1	8.3
Haematopoietic and lymphoid	NALM6	8.1
Haematopoietic and lymphoid	NAMALWA	8.2
Haematopoietic and lymphoid	NB4	8.2
Haematopoietic and lymphoid	NCIH929	7.5
Haematopoietic and lymphoid	NCO2	7.4
Haematopoietic and lymphoid	NOMO1	8.8
Haematopoietic and lymphoid	NUDHL1	8.2
Haematopoietic and lymphoid	NUDUL1	8.7
Haematopoietic and lymphoid	OCIAML2	8.4
Haematopoietic and lymphoid	OCIAML3	8.5
Haematopoietic and lymphoid	OCIAML5	8.1
Haematopoietic and lymphoid	OCILY10	8.2
Haematopoietic and lymphoid	OCILY19	8.7
Haematopoietic and lymphoid	OCILY3	8.6
Haematopoietic and lymphoid	OCIM1	7.5
Haematopoietic and lymphoid	OPM2	7.8
Haematopoietic and lymphoid	P12ICHIKAWA	8
Haematopoietic and lymphoid	P31FUJ	7.7
Haematopoietic and lymphoid	P3HR1	7.9
Haematopoietic and lymphoid	PCM6	8.5
Haematopoietic and lymphoid	PEER	7.8
Haematopoietic and lymphoid	PF382	8.2
Haematopoietic and lymphoid	PFEIFFER	8.5
Haematopoietic and lymphoid	PL21	7.7
Haematopoietic and lymphoid	RAJI	7.8
Haematopoietic and lymphoid	RCHACV	8.1
Haematopoietic and lymphoid	REC1	7.8
Haematopoietic and lymphoid	REH	8.1
Haematopoietic and lymphoid	RI1	8.4
Haematopoietic and lymphoid	RL	8.1
Haematopoietic and lymphoid	RPMI8226	7.4
Haematopoietic and lymphoid	RPMI8402	8.2
Haematopoietic and lymphoid	RS411	7.8
Haematopoietic and lymphoid	SEM	7.6
Haematopoietic and lymphoid	SET2	8.3
Haematopoietic and lymphoid	SIGM5	8.4
Haematopoietic and lymphoid	SKM1	7.5
Haematopoietic and lymphoid	SKMM2	7.9
Haematopoietic and lymphoid	SR786	8.3
Haematopoietic and lymphoid	ST486	7.9
Haematopoietic and lymphoid	SUDHL10	7.8
Haematopoietic and lymphoid	SUDHL1	7.2
Haematopoietic and lymphoid	SUDHL4	7.8
Haematopoietic and lymphoid	SUDHL5	8.3
Haematopoietic and lymphoid	SUDHL6	7.8
Haematopoietic and lymphoid	SUDHL8	7.7
Haematopoietic and lymphoid	SUPB15	8.1
Haematopoietic and lymphoid	SUPHD1	8.6
Haematopoietic and lymphoid	SUPM2	7.6
Haematopoietic and lymphoid	SUPT11	8.6
Haematopoietic and lymphoid	SUPT1	7.8
Haematopoietic and lymphoid	TALL1	8.9
Haematopoietic and lymphoid	TF1	7.8
Haematopoietic and lymphoid	THP1	7.5
Haematopoietic and lymphoid	TO175T	7.9
Haematopoietic and lymphoid	TOLEDO	8.4
Haematopoietic and lymphoid	U266B1	8
Haematopoietic and lymphoid	U937	7.6
Haematopoietic and lymphoid	UT7	7.9
Haematopoietic and lymphoid	WSUDLCL2	7.6
Kidney	769P	7.6
Kidney	786O	7.2
Kidney	A498	7.2
Kidney	A704	6.6
Kidney	ACHN	6.5
Kidney	BFTC909	7.8
Kidney	CAKI1	7.4
Kidney	CAKI2	7.2
Kidney	CAL54	7.3
Kidney	KMRC1	7.3
Kidney	KMRC20	7.5
Kidney	KMRC2	7.3
Kidney	KMRC3	7.5
Kidney	OSRC2	7.4
Kidney	RCC10RGB	7.7
Kidney	SNU1272	7.5
Kidney	SNU349	7.2
Kidney	TUHR10TKB	8.3
Kidney	TUHR14TKB	7.7
Kidney	TUHR4TKB	7.4
Kidney	VMRCRCW	7.3
Kidney	VMRCRCZ	7.4
Large intestine	C2BBE1	8.3
Large intestine	CCK81	7.4
Large intestine	CL11	7.6
Large intestine	CL14	8.4
Large intestine	CL34	7.5
Large intestine	CL40	7.9
Large intestine	COLO205	7.4
Large intestine	COLO320	7.3
Large intestine	COLO678	9.1
Large intestine	CW2	7.9
Large intestine	DLD1	7.5
Large intestine	GP2D	8
Large intestine	HCC56	7.5
Large intestine	HCT116	7.4
Large intestine	HCT15	8
Large intestine	HS675T	7.6
Large intestine	HS698T	7.3
Large intestine	HT115	7.7
Large intestine	HT29	8.2
Large intestine	HT55	7.9
Large intestine	KM12	6.6
Large intestine	LOVO	7.5
Large intestine	LS1034	8.2
Large intestine	LS123	8.7
Large intestine	LS180	7.6
Large intestine	LS411N	7.3
Large intestine	LS513	7.2
Large intestine	MDST8	7.6
Large intestine	NCIH508	7.7
Large intestine	NCIH716	6.6
Large intestine	NCIH747	8.3
Large intestine	OUMS23	8.3
Large intestine	RCM1	7.7
Large intestine	RKO	7.1
Large intestine	SKCO1	8
Large intestine	SNU1040	8.4
Large intestine	SNU1197	7.9
Large intestine	SNU175	7.6
Large intestine	SNU283	7.9
Large intestine	SNU407	7.8
Large intestine	SNU503	7.6
Large intestine	SNU61	8.6
Large intestine	SNU81	7.6
Large intestine	SNUC1	7.8
Large intestine	SNUC2A	7.9
Large intestine	SNUC4	7.9
Large intestine	SNUC5	7.5
Large intestine	SW1116	7.9
Large intestine	SW1417	7.9
Large intestine	SW1463	8.2
Large intestine	SW403	7.8
Large intestine	SW480	7.4
Large intestine	SW48	7.5
Large intestine	SW620	8.2
Large intestine	SW837	7.9
Large intestine	SW948	7.6
Large intestine	T84	8.1
Liver	ALEXANDERCELLS	7.1
Liver	C3A	7
Liver	HEP3B217	9.2
Liver	HEPG2	7.3
Liver	HLE	7.5
Liver	HLF	7.7
Liver	HUH1	8
Liver	HUH6	7.6
Liver	HUH7	9.8
Liver	JHH1	8
Liver	JHH2	7.8
Liver	JHH4	7.4
Liver	JHH5	8.4
Liver	JHH6	7.6
Liver	JHH7	7.7
Liver	LI7	7.3
Liver	PLCPRF5	7.3
Liver	SKHEP1	7.3
Liver	SNU182	7.5
Liver	SNU387	10
Liver	SNU398	7.7
Liver	SNU423	7.9
Liver	SNU449	7
Liver	SNU475	9
Liver	SNU761	8.6
Liver	SNU878	6.9
Liver	SNU886	8
Lung	A549	7.6
Lung	ABC1	8.1
Lung	BEN	8
Lung	CAL12T	8.3
Lung	CALU1	7.6
Lung	CALU3	7.8
Lung	CALU6	7.6
Lung	CHAGOK1	7.3
Lung	COLO668	7.6
Lung	COLO699	7.4
Lung	CORL105	8.1
Lung	CORL23	8.5
Lung	CORL24	7.1
Lung	CORL279	7.6
Lung	CORL311	7.8
Lung	CORL47	7.2
Lung	CORL51	7.9
Lung	CORL88	7.9
Lung	CORL95	7.7
Lung	CPCN	7
Lung	DMS114	8.7
Lung	DMS153	7.9
Lung	DMS273	7.2
Lung	DMS454	7.8
Lung	DMS53	8.2
Lung	DMS79	7.9
Lung	DV90	7.3
Lung	EBC1	8.3
Lung	EPLC272H	8.1
Lung	HARA	8
Lung	HCC1171	7.3
Lung	HCC1195	8.2
Lung	HCC15	8
Lung	HCC2279	8.2
Lung	HCC2935	7.9
Lung	HCC33	7.4
Lung	HCC366	8.8
Lung	HCC4006	8.2
Lung	HCC44	7.3
Lung	HCC78	8.9
Lung	HCC827	7.9
Lung	HCC95	7.4
Lung	HLC1	7.6
Lung	HLFA	7.3
Lung	HS229T	7.2
Lung	HS618T	7.3
Lung	IALM	8.1
Lung	KNS62	7.9
Lung	LC1F	7.6
Lung	LC1SQSF	7.5
Lung	LCLC103H	7.2
Lung	LCLC97TM1	8.2
Lung	LK2	7.9
Lung	LOUNH91	7.4
Lung	LU65	7.5
Lung	LU99	7.6
Lung	LUDLU1	8
Lung	LXF289	8.5
Lung	MORCPR	7.7
Lung	NCIH1048	7.9
Lung	NCIH1092	8
Lung	NCIH1105	8.1
Lung	NCIH1155	7.5
Lung	NCIH1184	7.6
Lung	NCIH1299	7.4
Lung	NCIH1339	8
Lung	NCIH1341	7.2
Lung	NCIH1355	7.6
Lung	NCIH1373	7.8
Lung	NCIH1385	7.8
Lung	NCIH1395	8.4
Lung	NCIH1435	8.2
Lung	NCIH1436	7.7
Lung	NCIH1437	8
Lung	NCIH146	7.8
Lung	NCIH1563	8.4
Lung	NCIH1568	8.4
Lung	NCIH1573	8.4
Lung	NCIH1581	7.9
Lung	NCIH1618	8.4
Lung	NCIH1623	9.2
Lung	NCIH1648	8.4
Lung	NCIH1650	8.8
Lung	NCIH1651	7.7
Lung	NCIH1666	8
Lung	NCIH1693	8
Lung	NCIH1694	6.7
Lung	NCIH1703	7.4
Lung	NCIH1734	7.6
Lung	NCIH1755	7.8
Lung	NCIH1781	8.1
Lung	NCIH1792	9.2
Lung	NCIH1793	7.7
Lung	NCIH1836	7.6
Lung	NCIH1838	7.7
Lung	NCIH1869	8.9
Lung	NCIH1876	8
Lung	NCIH1915	8.2
Lung	NCIH1930	7.6
Lung	NCIH1944	7.1
Lung	NCIH1963	7.4
Lung	NCIH196	7.4
Lung	NCIH1975	9.3
Lung	NCIH2009	7.8
Lung	NCIH2023	7
Lung	NCIH2029	8
Lung	NCIH2030	7.5
Lung	NCIH2066	7.6
Lung	NCIH2081	7.3
Lung	NCIH2085	7.9
Lung	NCIH2087	8
Lung	NCIH209	7.5
Lung	NCIH2106	7.4
Lung	NCIH2110	7.9
Lung	NCIH211	8.2
Lung	NCIH2122	7.1
Lung	NCIH2126	8.6
Lung	NCIH2141	8.6
Lung	NCIH2170	8
Lung	NCIH2171	7.6
Lung	NCIH2172	7.8
Lung	NCIH2196	7.4
Lung	NCIH2227	8.1
Lung	NCIH2228	8.3
Lung	NCIH226	7.4
Lung	NCIH2286	8
Lung	NCIH2291	7.3
Lung	NCIH2342	8.5
Lung	NCIH2347	7.8
Lung	NCIH23	9
Lung	NCIH2405	8
Lung	NCIH2444	7.3
Lung	NCIH292	8.7
Lung	NCIH322	8.2
Lung	NCIH3255	8.2
Lung	NCIH358	7.9
Lung	NCIH441	8.5
Lung	NCIH446	7.1
Lung	NCIH460	7
Lung	NCIH510	8
Lung	NCIH520	7.9
Lung	NCIH522	8
Lung	NCIH524	6.7
Lung	NCIH526	7.8
Lung	NCIH596	8.2
Lung	NCIH647	7.6
Lung	NCIH650	8.1
Lung	NCIH661	7.3
Lung	NCIH69	7.2
Lung	NCIH727	8.3
Lung	NCIH810	7.4
Lung	NCIH82	7.2
Lung	NCIH838	8.2
Lung	NCIH841	7.5
Lung	NCIH854	7.9
Lung	NCIH889	7.2
Lung	PC14	8.8
Lung	RERFLCAD1	8.4
Lung	RERFLCAD2	8.7
Lung	RERFLCAI	7.9
Lung	RERFLCKJ	7.6
Lung	RERFLCMS	7.5
Lung	RERFLCSQ1	7.7
Lung	SBC5	7
Lung	SCLC21H	7.2
Lung	SHP77	7.9
Lung	SKLU1	8
Lung	SKMES1	7.5
Lung	SQ1	8.5
Lung	SW1271	7.8
Lung	SW1573	7.3
Lung	SW900	8
Lung	VMRCLCD	7.9
Lung	VMRCLCP	7.8
Oesophagus	COLO680N	9.6
Oesophagus	ECGI10	7.9
Oesophagus	KYSE140	7.6
Oesophagus	KYSE150	7.9
Oesophagus	KYSE180	9.8
Oesophagus	KYSE270	8.6
Oesophagus	KYSE30	8.8
Oesophagus	KYSE410	9.4
Oesophagus	KYSE450	8
Oesophagus	KYSE510	8.2
Oesophagus	KYSE520	9
Oesophagus	KYSE70	7.3
Oesophagus	OE19	8.3
Oesophagus	OE33	7.9
Oesophagus	TE10	9
Oesophagus	TE11	8.7
Oesophagus	TE14	8.4
Oesophagus	TE15	8.1
Oesophagus	TE1	8.3
Oesophagus	TE4	8.9
Oesophagus	TE5	8.8
Oesophagus	TE6	8.4
Oesophagus	TE8	8.1
Oesophagus	TE9	8.5
Oesophagus	TT	9.4
Ovary	59M	8
Ovary	A2780	7.7
Ovary	CAOV3	7.8
Ovary	CAOV4	7.9
Ovary	COLO704	7.4
Ovary	COV318	7.8
Ovary	COV362	8.1
Ovary	COV434	7.3
Ovary	COV504	7.8
Ovary	COV644	7.9
Ovary	EFO21	7.7
Ovary	EFO27	8.3
Ovary	ES2	7.4
Ovary	FUOV1	8
Ovary	HEYA8	7.1
Ovary	HS571T	7.3
Ovary	IGROV1	8.1
Ovary	JHOC5	7.5
Ovary	JHOM1	7.6
Ovary	JHOM2B	8
Ovary	JHOS2	8.3
Ovary	JHOS4	8.1
Ovary	KURAMOCHI	8.6
Ovary	MCAS	7.9
Ovary	NIHOVCAR3	8.3
Ovary	OAW28	8.8
Ovary	OAW42	7.7
Ovary	OC314	7.7
Ovary	OC316	7.7
Ovary	ONCODG1	8.1
Ovary	OV56	7.8
Ovary	OV7	7.9
Ovary	OV90	7.7
Ovary	OVCAR4	7.9
Ovary	OVCAR8	7.9
Ovary	OVISE	8
Ovary	OVK18	8
Ovary	OVKATE	8.7
Ovary	OVMANA	7.9
Ovary	OVSAHO	7.1
Ovary	OVTOKO	7.4
Ovary	RMGI	7.8
Ovary	RMUGS	8.4
Ovary	SKOV3	7.8
Ovary	SNU119	8.5
Ovary	SNU840	8.1
Ovary	SNU8	7.2
Ovary	TOV112D	7.1
Ovary	TOV21G	7.1
Ovary	TYKNU	7.7
Pancreas	ASPC1	8.3
Pancreas	BXPC3	8.3
Pancreas	CAPAN1	8.3
Pancreas	CAPAN2	7.9
Pancreas	CFPAC1	8.1
Pancreas	DANG	8.4
Pancreas	HPAC	9.3
Pancreas	HPAFII	8.1
Pancreas	HS766T	8.4
Pancreas	HUPT3	7.5
Pancreas	HUPT4	8.2
Pancreas	KCIMOH1	8
Pancreas	KLM1	8.8
Pancreas	KP2	8.3
Pancreas	KP3	8.1
Pancreas	KP4	7.4
Pancreas	L33	7.4
Pancreas	MIAPACA2	8.2
Pancreas	PANC0203	9
Pancreas	PANC0213	8.9
Pancreas	PANC0327	8.2
Pancreas	PANC0403	7.3
Pancreas	PANC0504	7.7
Pancreas	PANC0813	8.8
Pancreas	PANC1005	8.1
Pancreas	PANC1	8.3
Pancreas	PATU8902	8.6
Pancreas	PATU8988S	7.7
Pancreas	PATU8988T	8.1
Pancreas	PK1	7.7
Pancreas	PK45H	7.4
Pancreas	PK59	8.5
Pancreas	PL45	7.9
Pancreas	PSN1	8.1
Pancreas	QGP1	7.6
Pancreas	SNU213	8.4
Pancreas	SNU324	8.1
Pancreas	SNU410	7.4
Pancreas	SU8686	8.4
Pancreas	SUIT2	7.9
Pancreas	SW1990	7.7
Pancreas	T3M4	8.2
Pancreas	TCCPAN2	8
Pancreas	YAPC	8.6
Pleura	ACCMESO1	6.6
Pleura	DM3	7.3
Pleura	ISTMES1	7.7
Pleura	ISTMES2	7.9
Pleura	JL1	7.7
Pleura	MPP89	6.9
Pleura	MSTO211H	7
Pleura	NCIH2052	7.9
Pleura	NCIH2452	8
Pleura	NCIH28	7.4
Prostate	22RV1	7.4
Prostate	DU145	7.9
Prostate	LNCAPCLONEFGC	7.7
Prostate	MDAPCA2B	7.7
Prostate	NCIH660	7.6
Prostate	PC3	7.5
Prostate	VCAP	8.7
Salivary gland	A253	8.1
Salivary gland	YD15	7.9
Skin	A101D	7.2
Skin	A2058	7.3
Skin	A375	7.4
Skin	C32	7.5
Skin	CHL1	6.6
Skin	CJM	7.7
Skin	COLO679	7
Skin	COLO741	7
Skin	COLO783	7
Skin	COLO792	7.5
Skin	COLO800	7.3
Skin	COLO818	6.7
Skin	COLO829	8
Skin	COLO849	7.5
Skin	G361	7
Skin	GRM	8.3
Skin	HMCB	6.8
Skin	HS294T	7.3
Skin	HS600T	7.4
Skin	HS688AT	7.5
Skin	HS695T	7
Skin	HS839T	7.5
Skin	HS852T	7.5
Skin	HS895T	7
Skin	HS934T	7.6
Skin	HS936T	6.3
Skin	HS939T	7.2
Skin	HS940T	7.4
Skin	HS944T	7.1
Skin	HT144	7.2
Skin	IGR1	6.5
Skin	IGR37	7.1
Skin	IGR39	7.3
Skin	IPC298	6.8
Skin	K029AX	7.6
Skin	LOXIMVI	7.7
Skin	MALME3M	6.2
Skin	MDAMB435S	7.2
Skin	MELHO	7.4
Skin	MELJUSO	7.3
Skin	MEWO	7.4
Skin	RPMI7951	7.4
Skin	RVH421	7.4
Skin	SH4	7.2
Skin	SKMEL1	7
Skin	SKMEL24	7.1
Skin	SKMEL28	6.6
Skin	SKMEL2	6
Skin	SKMEL30	8.2
Skin	SKMEL31	7.4
Skin	SKMEL3	7.5
Skin	SKMEL5	6.6
Skin	UACC257	7.2
Skin	UACC62	7.3
Skin	WM115	7.3
Skin	WM1799	7.8
Skin	WM2664	7.5
Skin	WM793	7.4
Skin	WM88	6.9
Skin	WM983B	7.5
Small intestine	HUTU80	7.4
Soft tissue	A204	7.6
Soft tissue	G401	7.5
Soft tissue	G402	7.9
Soft tissue	GCT	8
Soft tissue	HS729	7.8
Soft tissue	HT1080	7.3
Soft tissue	KYM1	7.6
Soft tissue	MESSA	7.6
Soft tissue	RD	7.4
Soft tissue	RH30	8
Soft tissue	RH41	7.1
Soft tissue	RKN	7
Soft tissue	S117	7.6
Soft tissue	SJRH30	7.5
Soft tissue	SKLMS1	7.8
Soft tissue	SKUT1	8
Soft tissue	TE125T	7
Soft tissue	TE159T	7.8
Soft tissue	TE441T	7.8
Soft tissue	TE617T	7.6
Stomach	2313287	7.7
Stomach	AGS	7.4
Stomach	AZ521	7.5
Stomach	ECC10	7.9
Stomach	ECC12	8.1
Stomach	FU97	8
Stomach	GCIY	7.3
Stomach	GSS	8.4
Stomach	GSU	7.8
Stomach	HGC27	7.4
Stomach	HS746T	7.6
Stomach	HUG1N	7.8
Stomach	IM95	7.5
Stomach	KATOIII	7.9
Stomach	KE39	8
Stomach	LMSU	8.5
Stomach	MKN1	7.6
Stomach	MKN45	8.1
Stomach	MKN74	8.7
Stomach	MKN7	8.3
Stomach	NCCSTCK140	9
Stomach	NCIN87	8.2
Stomach	NUGC2	8.4
Stomach	NUGC3	7.5
Stomach	NUGC4	7.8
Stomach	OCUM1	8.1
Stomach	RERFGC1B	8.6
Stomach	SH10TC	7.2
Stomach	SNU16	7.9
Stomach	SNU1	7.7
Stomach	SNU216	8.8
Stomach	SNU520	7.8
Stomach	SNU5	8.3
Stomach	SNU601	8.5
Stomach	SNU620	7.3
Stomach	SNU668	7
Stomach	SNU719	7.4
Stomach	TGBC11TKB	7.9
Thyroid	8305C	7.3
Thyroid	8505C	7.9
Thyroid	BCPAP	7.9
Thyroid	BHT101	7.7
Thyroid	CAL62	8.2
Thyroid	CGTHW1	8.6
Thyroid	FTC133	7.1
Thyroid	FTC238	7.2
Thyroid	ML1	7.1
Thyroid	SW579	7.9
Thyroid	TT2609C02	8.2
Thyroid	TT	8.2
Upper aerodigestive tract	BHY	8.5
Upper aerodigestive tract	BICR16	8.3
Upper aerodigestive tract	BICR18	8.1
Upper aerodigestive tract	BICR22	9
Upper aerodigestive tract	BICR31	8.4
Upper aerodigestive tract	BICR56	8.2
Upper aerodigestive tract	BICR6	8.9
Upper aerodigestive tract	CAL27	8.7
Upper aerodigestive tract	CAL33	7.9
Upper aerodigestive tract	DETROIT562	8.9
Upper aerodigestive tract	FADU	8.9
Upper aerodigestive tract	HS840T	7.3
Upper aerodigestive tract	HSC2	8.7
Upper aerodigestive tract	HSC3	7.9
Upper aerodigestive tract	HSC4	9.8
Upper aerodigestive tract	PECAPJ15	8.8
Upper aerodigestive tract	PECAPJ34CLONEC12	9.4
Upper aerodigestive tract	PECAPJ41CLONED2	8.5
Upper aerodigestive tract	PECAPJ49	8.2
Upper aerodigestive tract	SCC15	9.8
Upper aerodigestive tract	SCC25	8.6
Upper aerodigestive tract	SCC4	9
Upper aerodigestive tract	SCC9	8.9
Upper aerodigestive tract	SNU1076	8.4
Upper aerodigestive tract	SNU1214	7.7
Upper aerodigestive tract	SNU46	8.1
Upper aerodigestive tract	SNU899	8.5
Upper aerodigestive tract	YD10B	8.5
Upper aerodigestive tract	YD38	7.9
Upper aerodigestive tract	YD8	8.3
Urinary tract	5637	7.9
Urinary tract	639V	8.3
Urinary tract	647V	8.4
Urinary tract	BC3C	7.7
Urinary tract	BFTC905	9.3
Urinary tract	CAL29	10.3
Urinary tract	HS172T	7.6
Urinary tract	HT1197	7.7
Urinary tract	HT1376	8.2
Urinary tract	J82	7.8
Urinary tract	JMSU1	8.1
Urinary tract	KMBC2	8.4
Urinary tract	KU1919	9.4
Urinary tract	RT11284	7.6
Urinary tract	RT112	7.7
Urinary tract	RT4	7.6
Urinary tract	SCABER	8.7
Urinary tract	SW1710	7.7
Urinary tract	SW780	7.9
Urinary tract	T24	8.1
Urinary tract	TCCSUP	8
Urinary tract	UMUC1	8
Urinary tract	UMUC3	8.1
Urinary tract	VMCUB1	9.7

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	24
Adrenal gland	19.4
Appendix	42.7
Bone marrow	32
Breast	22.3
Cerebral cortex	19.9
Cervix, uterine	31.5
Colon	16.9
Duodenum	18.2
Endometrium	39
Epididymis	23.7
Esophagus	33.4
Fallopian tube	33.6
Gallbladder	34.4
Heart muscle	11
Kidney	16.5
Liver	9.4
Lung	31.4
Lymph node	37.4
Ovary	29.7
Pancreas	3.3
Parathyroid gland	44.5
Placenta	28.7
Prostate	28.6
Rectum	21.1
Salivary gland	8.7
Seminal vesicle	30
Skeletal muscle	11.7
Skin	28.4
Small intestine	23.5
Smooth muscle	38.5
Spleen	41.5
Stomach	19.7
Testis	59.8
Thyroid gland	34.5
Tonsil	30.8
Urinary bladder	28.1

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
26207617	Overexpression (copy number gain)	Breast Carcinoma	Two KDMs, KDM2A and KDM5B, had the highest frequency of genetic amplification and overexpression. Furthermore, among the 24 KDM genes, KDM2A had the highest correlation between copy number and mRNA expression, and high mRNA levels of KDM2A were significantly associated with shorter survival of breast cancer patients.
25029110	Overexpression	Breast Carcinoma	Here we show that KDM2A is strongly expressed in myoepithelial cells (MEPC) in breast cancer tissues by immunohistochemistry.
25245333	Overexpression	Gastric Carcinoma	Here, it was found that the expression level of KDM2A was increased in gastric cancer tissues.

Summary
Symbol	KDM2A
Name	lysine demethylase 2A
Aliases	KIAA1004; FBL11; LILINA; DKFZP434M1735; FLJ00115; CXXC8; JHDM1A; F-box protein FBL11; jumonji C domain-conta ......
Location	11q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.629	6.85e-46	18.1	55	27	Neutral
BRCA	Breast invasive carcinoma	1075	0.746	1.54e-191	14.1	58.2	27.6	Neutral
CESC	Cervical and endocervical cancers	292	0.528	2.19e-22	21.2	64	14.7	Neutral
COAD	Colon adenocarcinoma	449	0.379	8.79e-17	14.5	74.4	11.1	Neutral
ESCA	Esophageal carcinoma	183	0.635	4.97e-22	14.8	48.1	37.2	Gain
GBM	Glioblastoma multiforme	147	0.192	0.02	16.3	80.3	3.4	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.64	1.44e-60	9.5	55.8	34.6	Gain
KIRC	Kidney renal clear cell carcinoma	525	0.316	1.19e-13	3.4	90.1	6.5	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.297	2.77e-07	5.6	91.3	3.1	Neutral
LAML	Acute Myeloid Leukemia	166	0.377	5.49e-07	0	96.4	3.6	Neutral
LGG	Brain Lower Grade Glioma	513	0.259	2.7e-09	3.9	86	10.1	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.63	1.15e-41	17	71.4	11.5	Neutral
LUAD	Lung adenocarcinoma	512	0.451	5.88e-27	11.3	56.4	32.2	Neutral
LUSC	Lung squamous cell carcinoma	498	0.548	2.38e-40	19.1	53	27.9	Neutral
OV	Ovarian serous cystadenocarcinoma	300	0.546	9.57e-25	19	47.7	33.3	Neutral
PAAD	Pancreatic adenocarcinoma	177	0.5	1.34e-12	6.8	83.1	10.2	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.709	4.71e-26	22.2	74.1	3.7	Neutral
PRAD	Prostate adenocarcinoma	491	0.51	7.2e-34	0.8	89.4	9.8	Neutral
READ	Rectum adenocarcinoma	164	0.486	4.2e-11	20.7	63.4	15.9	Neutral
SARC	Sarcoma	255	0.539	1.35e-20	25.1	59.2	15.7	Neutral
SKCM	Skin Cutaneous Melanoma	367	0.701	1.5e-55	31.1	53.4	15.5	Neutral
STAD	Stomach adenocarcinoma	413	0.69	9.77e-60	10.9	66.8	22.3	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.183	0.0253	76.7	20	3.3	Loss
THCA	Thyroid carcinoma	497	0.332	2.86e-14	1.6	97.4	1	Neutral
THYM	Thymoma	119	0.366	4.23e-05	5.9	93.3	0.8	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.489	1.09e-33	9.1	78.4	12.5	Neutral

Summary
Symbol	KDM2A
Name	lysine demethylase 2A
Aliases	KIAA1004; FBL11; LILINA; DKFZP434M1735; FLJ00115; CXXC8; JHDM1A; F-box protein FBL11; jumonji C domain-conta ......
Location	11q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.337	1.37e-12	17	408	-0.01	0.0011	NS/NA
BRCA	Breast invasive carcinoma	-0.32	5.47e-24	83	785	-0.002	0.576	NS/NA
CESC	Cervical and endocervical cancers	-0.237	2.74e-05	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.279	5e-07	19	297	-0.02	0.616	NS/NA
ESCA	Esophageal carcinoma	-0.432	4.8e-10	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.16	0.202	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.316	6.55e-14	20	522	-0.005	0.282	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.166	0.00203	24	319	0.012	0.371	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.423	8.29e-15	23	275	0.15	8.87e-14	NS/NA
LAML	Acute Myeloid Leukemia	-0.348	3.76e-06	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.111	0.0108	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.24	8.86e-07	41	373	-0.007	1.48e-05	NS/NA
LUAD	Lung adenocarcinoma	-0.349	5.19e-15	21	456	-0.009	0.0114	NS/NA
LUSC	Lung squamous cell carcinoma	-0.454	0	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.833	0.00827	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.389	6.96e-08	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.412	6.23e-09	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.292	7.73e-12	35	498	0.012	5.5e-06	NS/NA
READ	Rectum adenocarcinoma	-0.433	7.58e-06	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.293	1.44e-06	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.462	0	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.405	0	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.604	0	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.255	1.18e-09	50	509	-0.127	4.84e-12	NS/NA
THYM	Thymoma	-0.16	0.078	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.33	3.59e-13	34	431	0.015	0.198	NS/NA

Summary
Symbol	KDM2A
Name	lysine demethylase 2A
Aliases	KIAA1004; FBL11; LILINA; DKFZP434M1735; FLJ00115; CXXC8; JHDM1A; F-box protein FBL11; jumonji C domain-conta ......
Location	11q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	3	High
Appendix	3	High
Bone marrow	3	High
Breast	2	Medium
Bronchus	3	High
Caudate	3	High
Cerebellum	3	High
Cerebral cortex	3	High
Cervix, uterine	3	High
Colon	3	High
Duodenum	3	High
Endometrium	3	High
Epididymis	3	High
Esophagus	3	High
Fallopian tube	3	High
Gallbladder	3	High
Heart muscle	3	High
Hippocampus	2	Medium
Kidney	3	High
Liver	2	Medium
Lung	3	High
Lymph node	3	High
Nasopharynx	3	High
Oral mucosa	3	High
Ovary	2	Medium
Pancreas	3	High
Parathyroid gland	3	High
Placenta	3	High
Prostate	2	Medium
Rectum	3	High
Salivary gland	3	High
Seminal vesicle	2	Medium
Skeletal muscle	3	High
Skin	3	High
Small intestine	3	High
Smooth muscle	2	Medium
Soft tissue	3	High
Spleen	3	High
Stomach	3	High
Testis	3	High
Thyroid gland	3	High
Tonsil	3	High
Urinary bladder	3	High
Vagina	3	High

Summary
Symbol	KDM2A
Name	lysine demethylase 2A
Aliases	KIAA1004; FBL11; LILINA; DKFZP434M1735; FLJ00115; CXXC8; JHDM1A; F-box protein FBL11; jumonji C domain-conta ......
Location	11q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.943	NS	24476821
BRCA	Breast invasive carcinoma	521	0.00721	Significant	23000897
COAD	Colon adenocarcinoma	149	0.0624	NS	22810696
GBM	Glioblastoma multiforme	157	0.0118	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	2.85e-08	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.0571	NS	26536169
LGG	Brain Lower Grade Glioma	513	0.0978	NS	26824661
LUAD	Lung adenocarcinoma	230	0.624	NS	25079552
LUSC	Lung squamous cell carcinoma	178	0.22	NS	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.0101	Significant	21720365
PRAD	Prostate adenocarcinoma	333	0.0722	NS	26544944
READ	Rectum adenocarcinoma	67	0.0784	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	9.39e-05	Significant	26091043
STAD	Stomach adenocarcinoma	277	0.0111	Significant	25079317
THCA	Thyroid carcinoma	391	3.62e-06	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	1.39e-06	Significant	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	0.754	0.163	NS
BRCA	Breast invasive carcinoma	1079	0.927	0.75	NS
CESC	Cervical and endocervical cancers	291	1.218	0.547	NS
COAD	Colon adenocarcinoma	439	0.983	0.957	NS
ESCA	Esophageal carcinoma	184	0.785	0.425	NS
GBM	Glioblastoma multiforme	158	1.244	0.395	NS
HNSC	Head and Neck squamous cell carcinoma	518	0.993	0.968	NS
KIRC	Kidney renal clear cell carcinoma	531	1.452	0.0658	NS
KIRP	Kidney renal papillary cell carcinoma	287	1.067	0.879	NS
LAML	Acute Myeloid Leukemia	149	1.125	0.689	NS
LGG	Brain Lower Grade Glioma	511	1.543	0.112	NS
LIHC	Liver hepatocellular carcinoma	365	0.861	0.542	NS
LUAD	Lung adenocarcinoma	502	0.741	0.15	NS
LUSC	Lung squamous cell carcinoma	494	1.046	0.819	NS
OV	Ovarian serous cystadenocarcinoma	303	1.295	0.204	NS
PAAD	Pancreatic adenocarcinoma	177	1.791	0.0454	Shorter
PCPG	Pheochromocytoma and Paraganglioma	179	4.86	0.113	NS
PRAD	Prostate adenocarcinoma	497	1.11	0.917	NS
READ	Rectum adenocarcinoma	159	0.566	0.373	NS
SARC	Sarcoma	259	0.743	0.28	NS
SKCM	Skin Cutaneous Melanoma	459	0.823	0.3	NS
STAD	Stomach adenocarcinoma	388	0.688	0.106	NS
TGCT	Testicular Germ Cell Tumors	134	1	1	NS
THCA	Thyroid carcinoma	500	0.392	0.245	NS
THYM	Thymoma	119	0.983	0.99	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	1.334	0.331	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	-0.042	0.403	NS
BRCA	Breast invasive carcinoma	1071	0	0.992	NS
CESC	Cervical and endocervical cancers	167	-0.052	0.508	NS
COAD	Colon adenocarcinoma	445	0.074	0.117	NS
ESCA	Esophageal carcinoma	162	-0.11	0.163	NS
HNSC	Head and Neck squamous cell carcinoma	448	-0.106	0.0249	Lower
KIRC	Kidney renal clear cell carcinoma	531	0.121	0.00524	Higher
KIRP	Kidney renal papillary cell carcinoma	260	-0.046	0.459	NS
LIHC	Liver hepatocellular carcinoma	347	-0.073	0.173	NS
LUAD	Lung adenocarcinoma	507	0.021	0.63	NS
LUSC	Lung squamous cell carcinoma	497	0.028	0.53	NS
OV	Ovarian serous cystadenocarcinoma	302	0.087	0.132	NS
PAAD	Pancreatic adenocarcinoma	176	0.159	0.0356	Higher
READ	Rectum adenocarcinoma	156	0.096	0.231	NS
SKCM	Skin Cutaneous Melanoma	410	-0.04	0.416	NS
STAD	Stomach adenocarcinoma	392	0.038	0.448	NS
TGCT	Testicular Germ Cell Tumors	81	-0.344	0.00168	Lower
THCA	Thyroid carcinoma	499	-0.086	0.0539	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.121	0.0069	Higher

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	-0.148	0.0145	Lower
HNSC	Head and Neck squamous cell carcinoma	498	-0.13	0.00357	Lower
KIRC	Kidney renal clear cell carcinoma	525	0.106	0.0154	Higher
LGG	Brain Lower Grade Glioma	514	0.087	0.0478	Higher
LIHC	Liver hepatocellular carcinoma	366	0.086	0.0986	NS
OV	Ovarian serous cystadenocarcinoma	296	0.115	0.0477	Higher
PAAD	Pancreatic adenocarcinoma	176	0.243	0.00114	Higher
STAD	Stomach adenocarcinoma	406	0.046	0.354	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.312	1.53e-13	Higher

Summary
Symbol	KDM2A
Name	lysine demethylase 2A
Aliases	KIAA1004; FBL11; LILINA; DKFZP434M1735; FLJ00115; CXXC8; JHDM1A; F-box protein FBL11; jumonji C domain-conta ......
Location	11q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	KDM2A
Name	lysine demethylase 2A
Aliases	KIAA1004; FBL11; LILINA; DKFZP434M1735; FLJ00115; CXXC8; JHDM1A; F-box protein FBL11; jumonji C domain-conta ......
Location	11q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for KDM2A.

Summary
Symbol	KDM2A
Name	lysine demethylase 2A
Aliases	KIAA1004; FBL11; LILINA; DKFZP434M1735; FLJ00115; CXXC8; JHDM1A; F-box protein FBL11; jumonji C domain-conta ......
Location	11q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining [ TOP ]
There is no record for KDM2A.