Browse KDM2B in pancancer

Summary
SymbolKDM2B
Namelysine demethylase 2B
Aliases PCCX2; CXXC2; Fbl10; JHDM1B; jumonji C domain-containing histone demethylase 1B; FBXL10; F-box and leucine-r ......
Location12q24.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Domain, Function and Classification
> Gene Ontology
> KEGG and Reactome Pathway
> Domain, Function and Classification
 
Domain PF00646 F-box domain
PF16866 PHD-finger
PF02008 CXXC zinc finger domain
Function

Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Classification
Class Modification Substrate Product PubMed
Histone modification erase Histone methylation H3K4me3, H3K36me2 H3K4, H3K36 17994099
> Gene Ontology
 
Biological Process GO:0001558 regulation of cell growth
GO:0001654 eye development
GO:0001838 embryonic epithelial tube formation
GO:0001841 neural tube formation
GO:0001843 neural tube closure
GO:0003002 regionalization
GO:0006482 protein demethylation
GO:0006513 protein monoubiquitination
GO:0007283 spermatogenesis
GO:0007389 pattern specification process
GO:0007423 sensory organ development
GO:0008214 protein dealkylation
GO:0009952 anterior/posterior pattern specification
GO:0010390 histone monoubiquitination
GO:0014020 primary neural tube formation
GO:0016049 cell growth
GO:0016331 morphogenesis of embryonic epithelium
GO:0016570 histone modification
GO:0016574 histone ubiquitination
GO:0016577 histone demethylation
GO:0019827 stem cell population maintenance
GO:0021532 neural tube patterning
GO:0021537 telencephalon development
GO:0021555 midbrain-hindbrain boundary morphogenesis
GO:0021591 ventricular system development
GO:0021592 fourth ventricle development
GO:0021670 lateral ventricle development
GO:0021678 third ventricle development
GO:0021903 rostrocaudal neural tube patterning
GO:0021915 neural tube development
GO:0021993 initiation of neural tube closure
GO:0030307 positive regulation of cell growth
GO:0030900 forebrain development
GO:0030901 midbrain development
GO:0030902 hindbrain development
GO:0030917 midbrain-hindbrain boundary development
GO:0031076 embryonic camera-type eye development
GO:0033522 histone H2A ubiquitination
GO:0035148 tube formation
GO:0035239 tube morphogenesis
GO:0035518 histone H2A monoubiquitination
GO:0043010 camera-type eye development
GO:0043523 regulation of neuron apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0045927 positive regulation of growth
GO:0048048 embryonic eye morphogenesis
GO:0048232 male gamete generation
GO:0048562 embryonic organ morphogenesis
GO:0048568 embryonic organ development
GO:0048592 eye morphogenesis
GO:0048593 camera-type eye morphogenesis
GO:0048596 embryonic camera-type eye morphogenesis
GO:0051402 neuron apoptotic process
GO:0060562 epithelial tube morphogenesis
GO:0060606 tube closure
GO:0061351 neural precursor cell proliferation
GO:0070076 histone lysine demethylation
GO:0070544 histone H3-K36 demethylation
GO:0070988 demethylation
GO:0070997 neuron death
GO:0072175 epithelial tube formation
GO:0090596 sensory organ morphogenesis
GO:0098727 maintenance of cell number
GO:1901214 regulation of neuron death
GO:1901215 negative regulation of neuron death
GO:1902459 positive regulation of stem cell population maintenance
GO:2000036 regulation of stem cell population maintenance
GO:2000177 regulation of neural precursor cell proliferation
GO:2000178 negative regulation of neural precursor cell proliferation
Molecular Function GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0001046 core promoter sequence-specific DNA binding
GO:0001047 core promoter binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0019843 rRNA binding
GO:0032451 demethylase activity
GO:0032452 histone demethylase activity
GO:0051213 dioxygenase activity
GO:0051864 histone demethylase activity (H3-K36 specific)
Cellular Component GO:0031519 PcG protein complex
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-3247509: Chromatin modifying enzymes
R-HSA-4839726: Chromatin organization
R-HSA-3214842: HDMs demethylate histones
Summary
SymbolKDM2B
Namelysine demethylase 2B
Aliases PCCX2; CXXC2; Fbl10; JHDM1B; jumonji C domain-containing histone demethylase 1B; FBXL10; F-box and leucine-r ......
Location12q24.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Mutation landscape in primary tumor tissue from TCGA
> Mutation landscape in cancer cell line from CCLE
> All mutations from COSMIC database V81
> Variations from text mining
> The Cancer Genome Atlas (TCGA)
 
> Cancer Cell Line Encyclopedia (CCLE)
 
There is no record.
> Catalogue of Somatic Mutations in Cancer (COSMIC)
 
COSMIC ID CDS change AA change Mutation Type Anatomical Site
COSM4747822c.1520delAp.K507fs*66Deletion - FrameshiftStomach
COSM3457165c.2562C>Tp.I854ISubstitution - coding silentSkin
COSM4386176c.1273C>Tp.P425SSubstitution - MissenseLarge_intestine
COSM3398448c.1861G>Ap.E621KSubstitution - MissenseCentral_nervous_system
COSM5645834c.686G>Tp.G229VSubstitution - MissenseOesophagus
COSM1211712c.1903C>Tp.R635CSubstitution - MissenseSkin
COSM3457174c.1877C>Tp.P626LSubstitution - MissenseSkin
COSM4596684c.1696C>Tp.P566SSubstitution - MissenseUpper_aerodigestive_tract
COSM5571569c.568G>Ap.V190ISubstitution - MissenseProstate
COSM5753887c.2913G>Ap.L971LSubstitution - coding silentLarge_intestine
COSM1285698c.1998A>Gp.P666PSubstitution - coding silentAutonomic_ganglia
COSM4410866c.2805delTp.H936fs*4Deletion - FrameshiftKidney
COSM3870947c.609C>Tp.I203ISubstitution - coding silentSkin
COSM3870947c.609C>Tp.I203ISubstitution - coding silentSkin
COSM5822607c.1245C>Tp.R415RSubstitution - coding silentLiver
COSM4694887c.2444G>Ap.R815QSubstitution - MissenseLarge_intestine
COSM145539c.1313A>Gp.H438RSubstitution - MissenseHaematopoietic_and_lymphoid_tissue
COSM4575114c.418G>Cp.E140QSubstitution - MissenseBone
COSM4384778c.2643G>Tp.K881NSubstitution - MissenseHaematopoietic_and_lymphoid_tissue
COSM936048c.329G>Ap.R110KSubstitution - MissenseEndometrium
COSM5989469c.214G>Tp.D72YSubstitution - MissenseHaematopoietic_and_lymphoid_tissue
COSM430541c.2304C>Ap.L768LSubstitution - coding silentBreast
COSM347815c.1755G>Cp.L585LSubstitution - coding silentLung
COSM4410866c.2805delTp.H936fs*4Deletion - FrameshiftKidney
COSM4633537c.1585A>Gp.K529ESubstitution - MissenseLarge_intestine
COSM936028c.2857T>Cp.F953LSubstitution - MissenseEndometrium
COSM5573890c.1624_1625insCp.K542fs*76Insertion - FrameshiftProstate
COSM4694899c.1292G>Ap.R431HSubstitution - MissenseLarge_intestine
COSM4694883c.2865C>Ap.A955ASubstitution - coding silentLarge_intestine
COSM4384781c.2098G>Ap.A700TSubstitution - MissenseHaematopoietic_and_lymphoid_tissue
COSM5949193c.739C>Tp.R247WSubstitution - MissenseHaematopoietic_and_lymphoid_tissue
COSM3986706c.102G>Ap.R34RSubstitution - coding silentKidney
COSM4410866c.2805delTp.H936fs*4Deletion - FrameshiftKidney
COSM3457186c.619C>Tp.P207SSubstitution - MissenseSkin
COSM936038c.1810C>Ap.L604MSubstitution - MissenseEndometrium
COSM5618967c.2091C>Tp.D697DSubstitution - coding silentBreast
COSM692642c.2746G>Ap.D916NSubstitution - MissenseLung
COSM936042c.1343C>Tp.P448LSubstitution - MissenseEndometrium
COSM3811269c.196G>Ap.E66KSubstitution - MissenseBreast
COSM4039479c.1327C>Tp.R443WSubstitution - MissenseStomach
COSM4039463c.2860A>Gp.I954VSubstitution - MissenseStomach
COSM4384787c.1273C>Ap.P425TSubstitution - MissenseHaematopoietic_and_lymphoid_tissue
COSM3670998c.1623C>Tp.P541PSubstitution - coding silentProstate
COSM936030c.2584C>Ap.L862MSubstitution - MissenseEndometrium
COSM3416558c.898G>Ap.V300MSubstitution - MissenseLarge_intestine
COSM5744476c.784G>Ap.E262KSubstitution - MissenseSmall_intestine
COSM936036c.2131G>Ap.A711TSubstitution - MissenseEndometrium
COSM1299021c.1027G>Tp.E343*Substitution - NonsenseUrinary_tract
COSM353795c.1704G>Ap.E568ESubstitution - coding silentLung
COSM3870944c.2011C>Tp.P671SSubstitution - MissenseSkin
COSM1359473c.2609G>Ap.R870QSubstitution - MissenseLarge_intestine
COSM5046111c.2143T>Cp.Y715HSubstitution - MissenseOesophagus
COSM4410866c.2805delTp.H936fs*4Deletion - FrameshiftKidney
COSM5571569c.568G>Ap.V190ISubstitution - MissenseProstate
COSM3752976c.2487G>Ap.Q829QSubstitution - coding silentLarge_intestine
COSM4652148c.2196C>Tp.N732NSubstitution - coding silentLarge_intestine
COSM4482959c.1575C>Tp.L525LSubstitution - coding silentSkin
COSM4039473c.2228G>Ap.R743HSubstitution - MissenseStomach
COSM4410866c.2805delTp.H936fs*4Deletion - FrameshiftKidney
COSM4694902c.1066T>Cp.W356RSubstitution - MissenseLarge_intestine
COSM936046c.393G>Tp.K131NSubstitution - MissenseEndometrium
COSM3368691c.2714C>Ap.T905NSubstitution - MissenseThyroid
COSM4852329c.2866G>Ap.E956KSubstitution - MissenseCervix
COSM1318048c.1711_1713delAAGp.K571delKDeletion - In frameHaematopoietic_and_lymphoid_tissue
COSM3457183c.1275G>Ap.P425PSubstitution - coding silentSkin
COSM4410866c.2805delTp.H936fs*4Deletion - FrameshiftKidney
COSM5352132c.1451G>Ap.W484*Substitution - NonsenseKidney
COSM3457168c.2300C>Tp.S767FSubstitution - MissenseSkin
COSM4426195c.2785A>Gp.K929ESubstitution - MissenseOesophagus
COSM1476252c.2361G>Tp.L787LSubstitution - coding silentBreast
COSM1255487c.2736C>Ap.I912ISubstitution - coding silentOesophagus
COSM4694905c.933C>Tp.D311DSubstitution - coding silentLarge_intestine
COSM3870947c.609C>Tp.I203ISubstitution - coding silentSkin
COSM3457168c.2300C>Tp.S767FSubstitution - MissenseSkin
COSM936032c.2491C>Tp.R831WSubstitution - MissenseEndometrium
COSM3870947c.609C>Tp.I203ISubstitution - coding silentSkin
COSM5659906c.877-3C>Gp.?UnknownSoft_tissue
COSM4694908c.713C>Tp.A238VSubstitution - MissenseLarge_intestine
COSM1628422c.967A>Tp.M323LSubstitution - MissenseLiver
COSM3457192c.468G>Ap.L156LSubstitution - coding silentSkin
COSM5929407c.1388C>Tp.S463FSubstitution - MissenseSkin
COSM4388262c.2490G>Ap.M830ISubstitution - MissensePancreas
COSM1677420c.752G>Ap.R251QSubstitution - MissenseLarge_intestine
COSM3980837c.210C>Tp.G70GSubstitution - coding silentOvary
COSM1359479c.1639G>Ap.D547NSubstitution - MissenseLarge_intestine
COSM301574c.1273_1274CC>AGp.P425>?ComplexLarge_intestine
COSM5374411c.166C>Tp.Q56*Substitution - NonsenseSkin
COSM5067026c.1020+9C>Ap.?UnknownLarge_intestine
COSM936034c.2391C>Tp.G797GSubstitution - coding silentEndometrium
COSM3457171c.2016C>Tp.P672PSubstitution - coding silentSkin
COSM1299023c.199G>Tp.E67*Substitution - NonsenseUrinary_tract
COSM4694911c.698C>Tp.A233VSubstitution - MissenseLarge_intestine
COSM1628422c.967A>Tp.M323LSubstitution - MissenseLiver
COSM5578797c.2850T>Ap.C950*Substitution - NonsenseSkin
COSM4039467c.2526A>Gp.P842PSubstitution - coding silentStomach
COSM5557571c.2046C>Tp.I682ISubstitution - coding silentProstate
COSM4039482c.765C>Tp.C255CSubstitution - coding silentStomach
COSM5940281c.494C>Tp.S165FSubstitution - MissenseSkin
COSM4765947c.1624_1625insCCp.K542fs*32Insertion - FrameshiftStomach
COSM4384784c.1831C>Tp.P611SSubstitution - MissenseHaematopoietic_and_lymphoid_tissue
COSM3752979c.1641C>Tp.D547DSubstitution - coding silentLarge_intestine
COSM4596684c.1696C>Tp.P566SSubstitution - MissenseUpper_aerodigestive_tract
COSM3870947c.609C>Tp.I203ISubstitution - coding silentSkin
COSM5469903c.1933C>Tp.R645WSubstitution - MissenseLarge_intestine
COSM2175897c.1235C>Tp.A412VSubstitution - MissenseLarge_intestine
COSM4524783c.208G>Tp.G70CSubstitution - MissenseSkin
COSM2175947c.478G>Ap.V160MSubstitution - MissenseLarge_intestine
COSM4694893c.1933_1934insCp.R645fs*48Insertion - FrameshiftLarge_intestine
COSM5623794c.2777C>Gp.S926CSubstitution - MissenseOesophagus
COSM3384099c.2396C>Tp.S799LSubstitution - MissensePancreas
COSM3870941c.2527+2T>Gp.?UnknownSkin
COSM4575110c.2412G>Ap.S804SSubstitution - coding silentBone
COSM3457180c.1767G>Ap.L589LSubstitution - coding silentSkin
COSM5903018c.2366-5C>Tp.?UnknownSkin
COSM1582125c.1724G>Ap.R575HSubstitution - MissenseStomach
COSM4852137c.1699G>Ap.E567KSubstitution - MissenseCervix
COSM1743614c.409C>Tp.P137SSubstitution - MissenseBiliary_tract
COSM1605670c.2362C>Ap.P788TSubstitution - MissenseLiver
COSM4842411c.181G>Cp.E61QSubstitution - MissenseCervix
COSM692638c.521C>Tp.P174LSubstitution - MissenseLung
COSM1211714c.1666G>Ap.A556TSubstitution - MissenseLarge_intestine
COSM4925964c.134C>Ap.S45YSubstitution - MissenseLiver
COSM1359475c.2170_2171delTGp.C724fs*14Deletion - FrameshiftLarge_intestine
COSM3792274c.2411C>Tp.S804LSubstitution - MissenseUrinary_tract
COSM1684353c.1703_1705delAGAp.K571delKDeletion - In frameOvary
COSM3457189c.596C>Tp.P199LSubstitution - MissenseSkin
COSM1677417c.2305G>Tp.D769YSubstitution - MissenseOvary
COSM3398452c.839G>Ap.R280HSubstitution - MissenseCentral_nervous_system
COSM1359477c.2063G>Tp.S688ISubstitution - MissenseLarge_intestine
COSM289704c.1376C>Tp.S459LSubstitution - MissenseLarge_intestine
COSM3935780c.1549C>Tp.R517CSubstitution - MissenseOesophagus
COSM1211712c.1903C>Tp.R635CSubstitution - MissenseLarge_intestine
COSM4745555c.1080_1081GT>AGp.C361GSubstitution - MissenseLarge_intestine
COSM4384775c.2672C>Tp.T891ISubstitution - MissenseHaematopoietic_and_lymphoid_tissue
COSM1162991c.345G>Ap.E115ESubstitution - coding silentPancreas
COSM4385674c.1387_1388insCp.G465fs*38Insertion - FrameshiftHaematopoietic_and_lymphoid_tissue
COSM3376151c.72G>Cp.Q24HSubstitution - MissensePancreas
COSM240321c.450G>Tp.E150DSubstitution - MissenseProstate
COSM2175825c.2251T>Cp.S751PSubstitution - MissenseLarge_intestine
COSM5480334c.289G>Ap.G97RSubstitution - MissenseLarge_intestine
COSM1211719c.788G>Ap.C263YSubstitution - MissenseOesophagus
COSM5831997c.1623_1624insCp.K542fs*76Insertion - FrameshiftBreast
COSM1359470c.2777C>Tp.S926FSubstitution - MissenseLarge_intestine
COSM1211717c.1114C>Tp.R372CSubstitution - MissenseLarge_intestine
COSM2175959c.264G>Ap.T88TSubstitution - coding silentProstate
COSM5635324c.1281C>Tp.D427DSubstitution - coding silentOesophagus
COSM3870947c.609C>Tp.I203ISubstitution - coding silentSkin
COSM1211719c.788G>Ap.C263YSubstitution - MissenseLarge_intestine
COSM4410866c.2805delTp.H936fs*4Deletion - FrameshiftKidney
COSM75103c.2587G>Tp.D863YSubstitution - MissenseOvary
COSM4039476c.2107G>Ap.V703ISubstitution - MissenseStomach
COSM3764382c.658G>Ap.A220TSubstitution - MissenseCentral_nervous_system
COSM3457165c.2562C>Tp.I854ISubstitution - coding silentSkin
COSM3739473c.831C>Gp.G277GSubstitution - coding silentLiver
COSM3986703c.1350G>Tp.E450DSubstitution - MissenseKidney
COSM5753887c.2913G>Ap.L971LSubstitution - coding silentLarge_intestine
COSM4650295c.1522C>Tp.R508WSubstitution - MissenseLarge_intestine
COSM4516137c.525_526GG>AAp.G176SSubstitution - MissenseSkin
COSM4765944c.2070_2071insCp.D692fs*1Insertion - FrameshiftStomach
COSM5078071c.1539C>Tp.N513NSubstitution - coding silentLarge_intestine
COSM3457177c.1841C>Tp.S614LSubstitution - MissenseSkin
COSM5671016c.1115G>Ap.R372HSubstitution - MissenseSoft_tissue
COSM4039470c.2288G>Ap.R763QSubstitution - MissenseStomach
COSM3752976c.2487G>Ap.Q829QSubstitution - coding silentBreast
COSM5012630c.1107A>Tp.K369NSubstitution - MissenseKidney
COSM5734630c.2753A>Gp.N918SSubstitution - MissensePancreas
COSM4694896c.1933delCp.R645fs*37Deletion - FrameshiftStomach
COSM2175962c.187_189delGAGp.E63delEDeletion - In frameSoft_tissue
COSM4747822c.1520delAp.K507fs*66Deletion - FrameshiftLarge_intestine
COSM5570113c.610A>Cp.T204PSubstitution - MissenseProstate
COSM3811265c.2893C>Ap.Q965KSubstitution - MissenseBreast
COSM4855986c.1941G>Ap.L647LSubstitution - coding silentCervix
COSM4168963c.742C>Gp.R248GSubstitution - MissensePeritoneum
COSM4410866c.2805delTp.H936fs*4Deletion - FrameshiftKidney
COSM1732389c.745C>Tp.R249WSubstitution - MissenseSoft_tissue
COSM4388590c.400A>Cp.T134PSubstitution - MissensePancreas
COSM4913993c.2424C>Ap.S808RSubstitution - MissenseLiver
COSM1637763c.2400G>Ap.W800*Substitution - NonsenseBone
COSM1211717c.1114C>Tp.R372CSubstitution - MissenseBone
COSM1211717c.1114C>Tp.R372CSubstitution - MissenseLarge_intestine
COSM1605670c.2362C>Ap.P788TSubstitution - MissenseLiver
COSM1677420c.752G>Ap.R251QSubstitution - MissenseLarge_intestine
COSM5623122c.2731delGp.E911fs*29Deletion - FrameshiftOesophagus
COSM3703908c.2140A>Tp.S714CSubstitution - MissenseLiver
COSM2175810c.2381T>Cp.V794ASubstitution - MissenseHaematopoietic_and_lymphoid_tissue
COSM269424c.285C>Ap.A95ASubstitution - coding silentLarge_intestine
COSM692640c.2158G>Cp.D720HSubstitution - MissenseLung
COSM5374415c.19G>Ap.E7KSubstitution - MissenseSkin
COSM4620318c.831C>Ap.G277GSubstitution - coding silentLarge_intestine
COSM355023c.317G>Ap.R106QSubstitution - MissenseLung
COSM936040c.1557G>Ap.A519ASubstitution - coding silentEndometrium
COSM430543c.1576C>Tp.R526WSubstitution - MissenseBreast
COSM4747822c.1520delAp.K507fs*66Deletion - FrameshiftLarge_intestine
COSM1188631c.365C>Gp.S122CSubstitution - MissenseLung
COSM4410866c.2805delTp.H936fs*4Deletion - FrameshiftKidney
COSM1211714c.1666G>Ap.A556TSubstitution - MissenseLarge_intestine
COSM2175825c.2251T>Cp.S751PSubstitution - MissenseLarge_intestine
COSM415994c.1161C>Gp.L387LSubstitution - coding silentUrinary_tract
COSM4694896c.1933delCp.R645fs*37Deletion - FrameshiftLarge_intestine
COSM4880425c.1569G>Ap.K523KSubstitution - coding silentProstate
COSM4694890c.1943G>Ap.R648QSubstitution - MissenseLarge_intestine
COSM5005897c.2094T>Cp.D698DSubstitution - coding silentHaematopoietic_and_lymphoid_tissue
COSM3687997c.746G>Ap.R249QSubstitution - MissenseLarge_intestine
COSM4817690c.444C>Gp.L148LSubstitution - coding silentCervix
COSM5550586c.1542C>Tp.A514ASubstitution - coding silentProstate
COSM6007926c.2719G>Ap.D907NSubstitution - MissenseProstate
COSM430545c.1335C>Tp.Y445YSubstitution - coding silentLarge_intestine
COSM145539c.1313A>Gp.H438RSubstitution - MissenseHaematopoietic_and_lymphoid_tissue
COSM5244665c.1244G>Cp.R415PSubstitution - MissenseLiver
COSM110184c.401C>Tp.T134ISubstitution - MissenseSkin
COSM3986700c.1351C>Tp.L451LSubstitution - coding silentKidney
COSM4694879c.2919delAp.K973fs*2Deletion - FrameshiftLarge_intestine
COSM1318050c.1775A>Gp.E592GSubstitution - MissenseHaematopoietic_and_lymphoid_tissue
COSM4384790c.431A>Gp.K144RSubstitution - MissenseHaematopoietic_and_lymphoid_tissue
COSM936042c.1343C>Tp.P448LSubstitution - MissenseSkin
COSM1211714c.1666G>Ap.A556TSubstitution - MissenseCentral_nervous_system
COSM3980834c.2527G>Cp.G843RSubstitution - MissenseOvary
COSM3398452c.839G>Ap.R280HSubstitution - MissenseStomach
COSM3870950c.321C>Tp.F107FSubstitution - coding silentSkin
> Text Mining based Variations
 
There is no record for KDM2B.
Summary
SymbolKDM2B
Namelysine demethylase 2B
Aliases PCCX2; CXXC2; Fbl10; JHDM1B; jumonji C domain-containing histone demethylase 1B; FBXL10; F-box and leucine-r ......
Location12q24.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Post-translational modification (PTM)
> Post-translational modification (PTM)
 
 Filter By:
Uniprot ID Position Amino Acid Description Upstream Enzyme Affected By Mutation Amino Acid Sequence Variant
Q8NHM5474SPhosphoserine-Yesp.S474F (cancer: HNSC)
Q8NHM5477SPhosphoserine-NoNone detected
Q8NHM5493TPhosphothreonine-NoNone detected
Q8NHM5497SPhosphoserine-NoNone detected
Q8NHM5951SPhosphoserine-NoNone detected
Q8NHM5975SPhosphoserine-Yesp.S975L (cancer: SKCM)
Q8NHM5979SPhosphoserine-Yesp.S979N (cancer: PAAD)
Q8NHM51018SPhosphoserine-NoNone detected
Q8NHM51031SPhosphoserine-NoNone detected
Summary
SymbolKDM2B
Namelysine demethylase 2B
Aliases PCCX2; CXXC2; Fbl10; JHDM1B; jumonji C domain-containing histone demethylase 1B; FBXL10; F-box and leucine-r ......
Location12q24.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Expression analysis in primary tumor tissue from TCGA
> Expression level in cancer cell line from CCLE
> Expression level in human normal tissue from HPA
> Text mining based expression change
> The Cancer Genome Atlas (TCGA)
 


  Differential expression analysis for cancers with more than 10 normal samples
Cancer Full Name # N # T Median (N) Median (T) LogFC Adj. P Status
BLCABladder urothelial carcinoma194085.1485.4560.2890.0152NS
BRCABreast invasive carcinoma11211004.9295.2430.43.49e-17NS
CESCCervical and endocervical cancers33064.6955.6NANANA
COADColon adenocarcinoma414594.7535.2330.4881.97e-14NS
ESCAEsophageal carcinoma111855.0955.6590.4450.0169NS
GBMGlioblastoma multiforme51665.5825.355NANANA
HNSCHead and Neck squamous cell carcinoma445225.3715.234-0.0080.929NS
KIRCKidney renal clear cell carcinoma725344.4694.8760.4243.11e-18NS
KIRPKidney renal papillary cell carcinoma322914.474.8310.4153.03e-07NS
LAMLAcute Myeloid Leukemia0173NA6.801NANANA
LGGBrain Lower Grade Glioma0530NA5.615NANANA
LIHCLiver hepatocellular carcinoma503734.1754.087-0.0770.439NS
LUADLung adenocarcinoma595175.0894.948-0.0920.169NS
LUSCLung squamous cell carcinoma515015.1315.4580.3635.09e-06NS
OVOvarian serous cystadenocarcinoma0307NA5.758NANANA
PAADPancreatic adenocarcinoma41795.1124.728NANANA
PCPGPheochromocytoma and Paraganglioma31843.9544.561NANANA
PRADProstate adenocarcinoma524984.4574.297-0.1730.00986NS
READRectum adenocarcinoma101674.935.2190.4480.000964NS
SARCSarcoma22634.4755.218NANANA
SKCMSkin Cutaneous Melanoma14725.5965.462NANANA
STADStomach adenocarcinoma354155.1425.4790.2870.00185NS
TGCTTesticular Germ Cell Tumors0156NA6.682NANANA
THCAThyroid carcinoma595094.7794.587-0.2132.94e-05NS
THYMThymoma21206.1455.572NANANA
UCECUterine Corpus Endometrial Carcinoma355465.255.5910.3484.11e-05NS
> Cancer Cell Line Encyclopedia (CCLE)
 



Tissue Cell Line Expression Level (Microarray)
Autonomic ganglia CHP126 9.6
Autonomic ganglia CHP212 9.2
Autonomic ganglia IMR32 10.4
Autonomic ganglia KELLY 9.3
Autonomic ganglia KPNRTBM1 10.1
Autonomic ganglia KPNSI9S 8.2
Autonomic ganglia KPNYN 9.8
Autonomic ganglia MHHNB11 9.5
Autonomic ganglia NB1 10.2
Autonomic ganglia NH6 10
Autonomic ganglia SHSY5Y 9.2
Autonomic ganglia SIMA 9.6
Autonomic ganglia SKNAS 9.6
Autonomic ganglia SKNBE2 9.9
Autonomic ganglia SKNDZ 10.3
Autonomic ganglia SKNFI 9.7
Autonomic ganglia SKNSH 9.4
Biliary tract HUCCT1 8.5
Biliary tract HUH28 8.2
Biliary tract SNU1079 8.8
Biliary tract SNU1196 8.5
Biliary tract SNU245 9.3
Biliary tract SNU308 8.3
Biliary tract SNU478 9.6
Bone 143B 8.6
Bone A673 8.9
Bone CADOES1 9.8
Bone CAL78 8.3
Bone G292CLONEA141B1 9.2
Bone HOS 8.9
Bone HS706T 8.5
Bone HS737T 8.4
Bone HS819T 7.7
Bone HS821T 8.4
Bone HS822T 8.3
Bone HS863T 8.1
Bone HS870T 8.2
Bone HS888T 9
Bone MG63 8.9
Bone MHHES1 9.4
Bone OUMS27 8.9
Bone RDES 10.4
Bone SJSA1 8.3
Bone SKES1 10.5
Bone SKNMC 10.1
Bone SW1353 8.8
Bone T173 7.9
Bone TC71 9.2
Bone U2OS 8.8
Breast AU565 8.5
Breast BT20 8.2
Breast BT474 9.6
Breast BT483 9.6
Breast BT549 8.1
Breast CAL120 8.3
Breast CAL148 10.5
Breast CAL51 9.6
Breast CAL851 8.4
Breast CAMA1 8.4
Breast DU4475 9.2
Breast EFM192A 8.4
Breast EFM19 9.9
Breast EVSAT 9.2
Breast HCC1143 8.2
Breast HCC1187 10
Breast HCC1395 8.2
Breast HCC1419 8.8
Breast HCC1428 9.1
Breast HCC1500 9.6
Breast HCC1569 8.6
Breast HCC1599 9.9
Breast HCC1806 9.4
Breast HCC1937 8.5
Breast HCC1954 8.7
Breast HCC202 9.4
Breast HCC2157 9
Breast HCC2218 8.7
Breast HCC38 9.1
Breast HCC70 8.7
Breast HDQP1 9
Breast HMC18 8.8
Breast HS274T 7.8
Breast HS281T 8.5
Breast HS343T 8.7
Breast HS578T 8.5
Breast HS606T 8.1
Breast HS739T 8.4
Breast HS742T 8
Breast JIMT1 9.9
Breast KPL1 9.3
Breast MCF7 8.7
Breast MDAMB134VI 9.3
Breast MDAMB157 8.9
Breast MDAMB175VII 7.9
Breast MDAMB231 8.6
Breast MDAMB361 9.4
Breast MDAMB415 6.7
Breast MDAMB436 9.3
Breast MDAMB453 8.7
Breast MDAMB468 8.4
Breast SKBR3 8.3
Breast T47D 9.3
Breast UACC812 9
Breast UACC893 8.6
Breast YMB1 8.9
Breast ZR751 8.4
Breast ZR7530 8.2
Central nervous system 1321N1 9
Central nervous system 42MGBA 8.9
Central nervous system 8MGBA 8.2
Central nervous system A172 8.6
Central nervous system AM38 9
Central nervous system BECKER 8.6
Central nervous system CAS1 8.6
Central nervous system CCFSTTG1 8.9
Central nervous system D283MED 9.4
Central nervous system D341MED 8.8
Central nervous system DAOY 9.1
Central nervous system DBTRG05MG 8.5
Central nervous system DKMG 8.7
Central nervous system GAMG 8.4
Central nervous system GB1 9.4
Central nervous system GI1 8.6
Central nervous system GMS10 7.9
Central nervous system GOS3 8.5
Central nervous system H4 8.5
Central nervous system HS683 8.4
Central nervous system KALS1 9.4
Central nervous system KG1C 8.9
Central nervous system KNS42 8.3
Central nervous system KNS60 8.6
Central nervous system KNS81 8.4
Central nervous system KS1 8.6
Central nervous system LN18 8.9
Central nervous system LN229 8.2
Central nervous system M059K 7.9
Central nervous system MOGGCCM 8.1
Central nervous system MOGGUVW 8.4
Central nervous system NMCG1 8.2
Central nervous system ONS76 8.1
Central nervous system SF126 8.7
Central nervous system SF295 8.7
Central nervous system SNB19 8.5
Central nervous system SNU1105 8.5
Central nervous system SNU201 8.7
Central nervous system SNU466 9.2
Central nervous system SNU489 8.5
Central nervous system SNU626 8.5
Central nervous system SNU738 9.1
Central nervous system SW1088 8.5
Central nervous system SW1783 8.2
Central nervous system T98G 8.3
Central nervous system TM31 8.6
Central nervous system U118MG 8.8
Central nervous system U138MG 9
Central nervous system U251MG 8
Central nervous system U87MG 8.5
Central nervous system YH13 8.1
Central nervous system YKG1 9.1
Endometrium AN3CA 7.4
Endometrium COLO684 9
Endometrium EFE184 8
Endometrium EN 8.7
Endometrium ESS1 8.1
Endometrium HEC108 9.1
Endometrium HEC151 8.7
Endometrium HEC1A 8.2
Endometrium HEC1B 9
Endometrium HEC251 8.7
Endometrium HEC265 8.7
Endometrium HEC50B 8.4
Endometrium HEC59 9.2
Endometrium HEC6 9.1
Endometrium ISHIKAWAHERAKLIO02ER 9.3
Endometrium JHUEM1 8.5
Endometrium JHUEM2 9.6
Endometrium JHUEM3 8.8
Endometrium KLE 8.3
Endometrium MFE280 9.4
Endometrium MFE296 9.3
Endometrium MFE319 7.8
Endometrium RL952 9.3
Endometrium SNGM 8.6
Endometrium SNU1077 8.5
Endometrium SNU685 9.3
Endometrium TEN 8.9
Haematopoietic and lymphoid 697 10.6
Haematopoietic and lymphoid A3KAW 9.7
Haematopoietic and lymphoid A4FUK 9.6
Haematopoietic and lymphoid ALLSIL 10.8
Haematopoietic and lymphoid AML193 9.6
Haematopoietic and lymphoid AMO1 9.4
Haematopoietic and lymphoid BCP1 9.6
Haematopoietic and lymphoid BDCM 9.8
Haematopoietic and lymphoid BL41 10.5
Haematopoietic and lymphoid BL70 10.7
Haematopoietic and lymphoid BV173 10
Haematopoietic and lymphoid CA46 9.8
Haematopoietic and lymphoid CI1 10.3
Haematopoietic and lymphoid CMK115 9.6
Haematopoietic and lymphoid CMK86 10.2
Haematopoietic and lymphoid CMK 10
Haematopoietic and lymphoid CMLT1 10.2
Haematopoietic and lymphoid COLO775 9.2
Haematopoietic and lymphoid DAUDI 9.8
Haematopoietic and lymphoid DB 10.2
Haematopoietic and lymphoid DEL 8.3
Haematopoietic and lymphoid DND41 10.9
Haematopoietic and lymphoid DOHH2 10.7
Haematopoietic and lymphoid EB1 10.2
Haematopoietic and lymphoid EB2 9.7
Haematopoietic and lymphoid EHEB 10.8
Haematopoietic and lymphoid EJM 9.8
Haematopoietic and lymphoid EM2 10.1
Haematopoietic and lymphoid EOL1 10.9
Haematopoietic and lymphoid F36P 9.7
Haematopoietic and lymphoid GA10 10.3
Haematopoietic and lymphoid GDM1 9.8
Haematopoietic and lymphoid GRANTA519 10.4
Haematopoietic and lymphoid HDLM2 9.5
Haematopoietic and lymphoid HDMYZ 8.1
Haematopoietic and lymphoid HEL9217 9.9
Haematopoietic and lymphoid HEL 9.7
Haematopoietic and lymphoid HH 8.9
Haematopoietic and lymphoid HL60 9.8
Haematopoietic and lymphoid HPBALL 10.8
Haematopoietic and lymphoid HS604T 7.9
Haematopoietic and lymphoid HS611T 10.1
Haematopoietic and lymphoid HS616T 7.9
Haematopoietic and lymphoid HS751T 8.5
Haematopoietic and lymphoid HT 10
Haematopoietic and lymphoid HTK 8.9
Haematopoietic and lymphoid HUNS1 10.3
Haematopoietic and lymphoid HUT102 9.1
Haematopoietic and lymphoid HUT78 9.6
Haematopoietic and lymphoid JEKO1 11.1
Haematopoietic and lymphoid JK1 9.4
Haematopoietic and lymphoid JM1 10.3
Haematopoietic and lymphoid JURKAT 10.1
Haematopoietic and lymphoid JURLMK1 10
Haematopoietic and lymphoid JVM2 10.6
Haematopoietic and lymphoid JVM3 11.2
Haematopoietic and lymphoid K562 8.7
Haematopoietic and lymphoid KARPAS299 9
Haematopoietic and lymphoid KARPAS422 10.5
Haematopoietic and lymphoid KARPAS620 9.9
Haematopoietic and lymphoid KASUMI1 10.2
Haematopoietic and lymphoid KASUMI2 10.9
Haematopoietic and lymphoid KASUMI6 10.4
Haematopoietic and lymphoid KCL22 9.6
Haematopoietic and lymphoid KE37 10.4
Haematopoietic and lymphoid KE97 10.1
Haematopoietic and lymphoid KG1 10
Haematopoietic and lymphoid KHM1B 9.4
Haematopoietic and lymphoid KIJK 8.6
Haematopoietic and lymphoid KMH2 11.7
Haematopoietic and lymphoid KMM1 9.3
Haematopoietic and lymphoid KMS11 9.1
Haematopoietic and lymphoid KMS12BM 10.1
Haematopoietic and lymphoid KMS18 10.1
Haematopoietic and lymphoid KMS20 10.4
Haematopoietic and lymphoid KMS21BM 9.1
Haematopoietic and lymphoid KMS26 8.6
Haematopoietic and lymphoid KMS27 8.9
Haematopoietic and lymphoid KMS28BM 8.7
Haematopoietic and lymphoid KMS34 9
Haematopoietic and lymphoid KO52 10.1
Haematopoietic and lymphoid KOPN8 11.3
Haematopoietic and lymphoid KU812 9.6
Haematopoietic and lymphoid KYO1 9.5
Haematopoietic and lymphoid L1236 8.1
Haematopoietic and lymphoid L363 9
Haematopoietic and lymphoid L428 8.2
Haematopoietic and lymphoid L540 9.3
Haematopoietic and lymphoid LAMA84 9.6
Haematopoietic and lymphoid LOUCY 10.4
Haematopoietic and lymphoid LP1 8.8
Haematopoietic and lymphoid M07E 9.9
Haematopoietic and lymphoid MC116 10.6
Haematopoietic and lymphoid ME1 10.8
Haematopoietic and lymphoid MEC1 10.3
Haematopoietic and lymphoid MEC2 10.5
Haematopoietic and lymphoid MEG01 9.6
Haematopoietic and lymphoid MHHCALL2 10.4
Haematopoietic and lymphoid MHHCALL3 11.2
Haematopoietic and lymphoid MHHCALL4 11
Haematopoietic and lymphoid MINO 10.9
Haematopoietic and lymphoid MJ 9.7
Haematopoietic and lymphoid MM1S 8.3
Haematopoietic and lymphoid MOLM13 10.3
Haematopoietic and lymphoid MOLM16 10
Haematopoietic and lymphoid MOLM6 10.1
Haematopoietic and lymphoid MOLP2 9.4
Haematopoietic and lymphoid MOLP8 9.5
Haematopoietic and lymphoid MOLT13 10.8
Haematopoietic and lymphoid MOLT16 10.4
Haematopoietic and lymphoid MOLT4 9.8
Haematopoietic and lymphoid MONOMAC1 10.8
Haematopoietic and lymphoid MONOMAC6 10.1
Haematopoietic and lymphoid MOTN1 10.1
Haematopoietic and lymphoid MUTZ5 11
Haematopoietic and lymphoid MV411 10.8
Haematopoietic and lymphoid NALM19 10.5
Haematopoietic and lymphoid NALM1 10.8
Haematopoietic and lymphoid NALM6 10.7
Haematopoietic and lymphoid NAMALWA 10.3
Haematopoietic and lymphoid NB4 10.9
Haematopoietic and lymphoid NCIH929 8.3
Haematopoietic and lymphoid NCO2 9.1
Haematopoietic and lymphoid NOMO1 10.3
Haematopoietic and lymphoid NUDHL1 10.5
Haematopoietic and lymphoid NUDUL1 10.5
Haematopoietic and lymphoid OCIAML2 11
Haematopoietic and lymphoid OCIAML3 9.9
Haematopoietic and lymphoid OCIAML5 11.1
Haematopoietic and lymphoid OCILY10 10.3
Haematopoietic and lymphoid OCILY19 10.9
Haematopoietic and lymphoid OCILY3 11.2
Haematopoietic and lymphoid OCIM1 8.8
Haematopoietic and lymphoid OPM2 8.8
Haematopoietic and lymphoid P12ICHIKAWA 10.5
Haematopoietic and lymphoid P31FUJ 9.6
Haematopoietic and lymphoid P3HR1 10.1
Haematopoietic and lymphoid PCM6 8.4
Haematopoietic and lymphoid PEER 10.2
Haematopoietic and lymphoid PF382 10.1
Haematopoietic and lymphoid PFEIFFER 10.7
Haematopoietic and lymphoid PL21 10
Haematopoietic and lymphoid RAJI 10.4
Haematopoietic and lymphoid RCHACV 11.3
Haematopoietic and lymphoid REC1 10.4
Haematopoietic and lymphoid REH 10.2
Haematopoietic and lymphoid RI1 11.4
Haematopoietic and lymphoid RL 9.9
Haematopoietic and lymphoid RPMI8226 9
Haematopoietic and lymphoid RPMI8402 10.6
Haematopoietic and lymphoid RS411 10.4
Haematopoietic and lymphoid SEM 10.6
Haematopoietic and lymphoid SET2 9.9
Haematopoietic and lymphoid SIGM5 10.5
Haematopoietic and lymphoid SKM1 9.7
Haematopoietic and lymphoid SKMM2 9.3
Haematopoietic and lymphoid SR786 9
Haematopoietic and lymphoid ST486 10.2
Haematopoietic and lymphoid SUDHL10 10.4
Haematopoietic and lymphoid SUDHL1 8.2
Haematopoietic and lymphoid SUDHL4 10.8
Haematopoietic and lymphoid SUDHL5 10.4
Haematopoietic and lymphoid SUDHL6 10.3
Haematopoietic and lymphoid SUDHL8 9.8
Haematopoietic and lymphoid SUPB15 10.4
Haematopoietic and lymphoid SUPHD1 8
Haematopoietic and lymphoid SUPM2 8.6
Haematopoietic and lymphoid SUPT11 10.8
Haematopoietic and lymphoid SUPT1 9.6
Haematopoietic and lymphoid TALL1 10.5
Haematopoietic and lymphoid TF1 9.1
Haematopoietic and lymphoid THP1 10.7
Haematopoietic and lymphoid TO175T 8.3
Haematopoietic and lymphoid TOLEDO 10.3
Haematopoietic and lymphoid U266B1 8.9
Haematopoietic and lymphoid U937 9.8
Haematopoietic and lymphoid UT7 9.6
Haematopoietic and lymphoid WSUDLCL2 10.3
Kidney 769P 7.8
Kidney 786O 8.6
Kidney A498 8
Kidney A704 8.5
Kidney ACHN 8.5
Kidney BFTC909 7.7
Kidney CAKI1 8.4
Kidney CAKI2 8.6
Kidney CAL54 9.2
Kidney KMRC1 8.1
Kidney KMRC20 8.2
Kidney KMRC2 8.5
Kidney KMRC3 7.9
Kidney OSRC2 9.1
Kidney RCC10RGB 8.1
Kidney SNU1272 8.6
Kidney SNU349 8.7
Kidney TUHR10TKB 9.9
Kidney TUHR14TKB 7.7
Kidney TUHR4TKB 8.8
Kidney VMRCRCW 7.3
Kidney VMRCRCZ 7.5
Large intestine C2BBE1 9
Large intestine CCK81 9.1
Large intestine CL11 9.4
Large intestine CL14 9.1
Large intestine CL34 8.7
Large intestine CL40 9.7
Large intestine COLO205 8.5
Large intestine COLO320 10.5
Large intestine COLO678 10.4
Large intestine CW2 9.3
Large intestine DLD1 8.6
Large intestine GP2D 10.2
Large intestine HCC56 9.2
Large intestine HCT116 9.4
Large intestine HCT15 8.4
Large intestine HS675T 8.2
Large intestine HS698T 7.8
Large intestine HT115 9.1
Large intestine HT29 8.1
Large intestine HT55 9.1
Large intestine KM12 8.3
Large intestine LOVO 9.6
Large intestine LS1034 8.6
Large intestine LS123 9.4
Large intestine LS180 9
Large intestine LS411N 8.8
Large intestine LS513 8.7
Large intestine MDST8 9.7
Large intestine NCIH508 8.4
Large intestine NCIH716 8.4
Large intestine NCIH747 8.5
Large intestine OUMS23 9
Large intestine RCM1 8.4
Large intestine RKO 9.3
Large intestine SKCO1 9.5
Large intestine SNU1040 9.6
Large intestine SNU1197 7.9
Large intestine SNU175 9.2
Large intestine SNU283 9.2
Large intestine SNU407 9.3
Large intestine SNU503 9.2
Large intestine SNU61 9.7
Large intestine SNU81 8.5
Large intestine SNUC1 9.5
Large intestine SNUC2A 9.1
Large intestine SNUC4 9.8
Large intestine SNUC5 9.1
Large intestine SW1116 8.7
Large intestine SW1417 8.6
Large intestine SW1463 9.3
Large intestine SW403 9.1
Large intestine SW480 8
Large intestine SW48 9.2
Large intestine SW620 8.8
Large intestine SW837 9.3
Large intestine SW948 9.1
Large intestine T84 9.6
Liver ALEXANDERCELLS 8.6
Liver C3A 9
Liver HEP3B217 9.3
Liver HEPG2 9.3
Liver HLE 7.7
Liver HLF 8
Liver HUH1 9.4
Liver HUH6 9.7
Liver HUH7 8.3
Liver JHH1 7.9
Liver JHH2 7.8
Liver JHH4 8.2
Liver JHH5 8.7
Liver JHH6 8.7
Liver JHH7 9.2
Liver LI7 9.4
Liver PLCPRF5 9
Liver SKHEP1 9
Liver SNU182 8.4
Liver SNU387 8.9
Liver SNU398 9.6
Liver SNU423 8.5
Liver SNU449 8.7
Liver SNU475 8.3
Liver SNU761 8.2
Liver SNU878 8.4
Liver SNU886 8.4
Lung A549 8.4
Lung ABC1 8.2
Lung BEN 8.1
Lung CAL12T 9.1
Lung CALU1 8
Lung CALU3 8.1
Lung CALU6 8.7
Lung CHAGOK1 8.7
Lung COLO668 9.9
Lung COLO699 9.6
Lung CORL105 8.8
Lung CORL23 9
Lung CORL24 9.9
Lung CORL279 9.2
Lung CORL311 10.6
Lung CORL47 10.2
Lung CORL51 9.9
Lung CORL88 9.5
Lung CORL95 9.8
Lung CPCN 9.3
Lung DMS114 9.2
Lung DMS153 8.1
Lung DMS273 9.8
Lung DMS454 8.8
Lung DMS53 8.6
Lung DMS79 9.6
Lung DV90 6.8
Lung EBC1 9
Lung EPLC272H 8.1
Lung HARA 9
Lung HCC1171 8.3
Lung HCC1195 9.2
Lung HCC15 8.6
Lung HCC2279 8.2
Lung HCC2935 7.5
Lung HCC33 9.7
Lung HCC366 8.4
Lung HCC4006 8.4
Lung HCC44 7.6
Lung HCC78 8.2
Lung HCC827 9.1
Lung HCC95 8.3
Lung HLC1 9.2
Lung HLFA 8.1
Lung HS229T 8.7
Lung HS618T 8.6
Lung IALM 9.2
Lung KNS62 8.2
Lung LC1F 8.9
Lung LC1SQSF 8.3
Lung LCLC103H 8.7
Lung LCLC97TM1 9.1
Lung LK2 9.6
Lung LOUNH91 8
Lung LU65 8.5
Lung LU99 10.7
Lung LUDLU1 8.5
Lung LXF289 8.5
Lung MORCPR 8.5
Lung NCIH1048 9.7
Lung NCIH1092 9
Lung NCIH1105 10.4
Lung NCIH1155 9
Lung NCIH1184 9.3
Lung NCIH1299 8.2
Lung NCIH1339 9.2
Lung NCIH1341 9
Lung NCIH1355 8.3
Lung NCIH1373 8.4
Lung NCIH1385 8.9
Lung NCIH1395 8
Lung NCIH1435 9
Lung NCIH1436 9.7
Lung NCIH1437 8.8
Lung NCIH146 9.2
Lung NCIH1563 8
Lung NCIH1568 9.8
Lung NCIH1573 8.3
Lung NCIH1581 9.4
Lung NCIH1618 9.3
Lung NCIH1623 8.5
Lung NCIH1648 8.7
Lung NCIH1650 8.5
Lung NCIH1651 8.4
Lung NCIH1666 7.9
Lung NCIH1693 8.5
Lung NCIH1694 9
Lung NCIH1703 8
Lung NCIH1734 8.5
Lung NCIH1755 8.5
Lung NCIH1781 7.2
Lung NCIH1792 9.3
Lung NCIH1793 8.2
Lung NCIH1836 9.7
Lung NCIH1838 8.3
Lung NCIH1869 8.6
Lung NCIH1876 10.2
Lung NCIH1915 8.6
Lung NCIH1930 8.6
Lung NCIH1944 8.3
Lung NCIH1963 9.6
Lung NCIH196 8
Lung NCIH1975 7.7
Lung NCIH2009 8.4
Lung NCIH2023 8
Lung NCIH2029 9.2
Lung NCIH2030 7.3
Lung NCIH2066 8.7
Lung NCIH2081 9.4
Lung NCIH2085 8.7
Lung NCIH2087 8.8
Lung NCIH209 8.6
Lung NCIH2106 9.2
Lung NCIH2110 9
Lung NCIH211 9.8
Lung NCIH2122 8
Lung NCIH2126 8.9
Lung NCIH2141 10.1
Lung NCIH2170 8.3
Lung NCIH2171 9.5
Lung NCIH2172 8.7
Lung NCIH2196 8.2
Lung NCIH2227 9.5
Lung NCIH2228 8.5
Lung NCIH226 7.9
Lung NCIH2286 9.3
Lung NCIH2291 8.4
Lung NCIH2342 8.7
Lung NCIH2347 8.3
Lung NCIH23 8.8
Lung NCIH2405 8.2
Lung NCIH2444 7.5
Lung NCIH292 8.5
Lung NCIH322 7.7
Lung NCIH3255 8.2
Lung NCIH358 8.3
Lung NCIH441 7
Lung NCIH446 9.4
Lung NCIH460 9
Lung NCIH510 9.6
Lung NCIH520 9.1
Lung NCIH522 8.8
Lung NCIH524 8.9
Lung NCIH526 10.1
Lung NCIH596 8
Lung NCIH647 8.6
Lung NCIH650 8.5
Lung NCIH661 8.7
Lung NCIH69 9.8
Lung NCIH727 8.7
Lung NCIH810 8.3
Lung NCIH82 9.5
Lung NCIH838 8.3
Lung NCIH841 9.8
Lung NCIH854 8.5
Lung NCIH889 9.6
Lung PC14 8.3
Lung RERFLCAD1 8.5
Lung RERFLCAD2 8.3
Lung RERFLCAI 8
Lung RERFLCKJ 8.3
Lung RERFLCMS 8
Lung RERFLCSQ1 8.2
Lung SBC5 8.7
Lung SCLC21H 9.8
Lung SHP77 9.4
Lung SKLU1 7.9
Lung SKMES1 8.3
Lung SQ1 8.2
Lung SW1271 8
Lung SW1573 8.6
Lung SW900 8.2
Lung VMRCLCD 9.3
Lung VMRCLCP 9.8
Oesophagus COLO680N 8.6
Oesophagus ECGI10 8.6
Oesophagus KYSE140 8.3
Oesophagus KYSE150 8.3
Oesophagus KYSE180 8.6
Oesophagus KYSE270 9.2
Oesophagus KYSE30 7.5
Oesophagus KYSE410 8.3
Oesophagus KYSE450 8.8
Oesophagus KYSE510 8.3
Oesophagus KYSE520 8.4
Oesophagus KYSE70 8.3
Oesophagus OE19 7.9
Oesophagus OE33 7.8
Oesophagus TE10 8.8
Oesophagus TE11 8.6
Oesophagus TE14 9.4
Oesophagus TE15 8.5
Oesophagus TE1 8.7
Oesophagus TE4 8.5
Oesophagus TE5 8.8
Oesophagus TE6 8.6
Oesophagus TE8 9.1
Oesophagus TE9 8.6
Oesophagus TT 8.7
Ovary 59M 7.9
Ovary A2780 9.6
Ovary CAOV3 8.6
Ovary CAOV4 9.1
Ovary COLO704 8.7
Ovary COV318 8
Ovary COV362 7.9
Ovary COV434 9.3
Ovary COV504 9
Ovary COV644 8.4
Ovary EFO21 8.9
Ovary EFO27 9
Ovary ES2 8.4
Ovary FUOV1 8.6
Ovary HEYA8 7.9
Ovary HS571T 7.5
Ovary IGROV1 8.6
Ovary JHOC5 8.5
Ovary JHOM1 8.8
Ovary JHOM2B 9.4
Ovary JHOS2 7.9
Ovary JHOS4 9.1
Ovary KURAMOCHI 8.5
Ovary MCAS 8.2
Ovary NIHOVCAR3 8.6
Ovary OAW28 9.1
Ovary OAW42 9.2
Ovary OC314 7.5
Ovary OC316 7.6
Ovary ONCODG1 9.1
Ovary OV56 7.6
Ovary OV7 8.7
Ovary OV90 8.9
Ovary OVCAR4 7.8
Ovary OVCAR8 8.7
Ovary OVISE 8.3
Ovary OVK18 9.3
Ovary OVKATE 7.9
Ovary OVMANA 9.3
Ovary OVSAHO 7.9
Ovary OVTOKO 8
Ovary RMGI 7.7
Ovary RMUGS 9.8
Ovary SKOV3 9.2
Ovary SNU119 8.6
Ovary SNU840 9.5
Ovary SNU8 8.6
Ovary TOV112D 9.9
Ovary TOV21G 8.6
Ovary TYKNU 8.4
Pancreas ASPC1 7.9
Pancreas BXPC3 9.3
Pancreas CAPAN1 8.4
Pancreas CAPAN2 7
Pancreas CFPAC1 8.2
Pancreas DANG 8.9
Pancreas HPAC 8.1
Pancreas HPAFII 8.4
Pancreas HS766T 7.9
Pancreas HUPT3 8.4
Pancreas HUPT4 9.3
Pancreas KCIMOH1 8
Pancreas KLM1 8.8
Pancreas KP2 8
Pancreas KP3 7.5
Pancreas KP4 8.8
Pancreas L33 8.1
Pancreas MIAPACA2 8.1
Pancreas PANC0203 8.3
Pancreas PANC0213 7.7
Pancreas PANC0327 8
Pancreas PANC0403 7.7
Pancreas PANC0504 8.3
Pancreas PANC0813 8.2
Pancreas PANC1005 7.3
Pancreas PANC1 8.4
Pancreas PATU8902 7.6
Pancreas PATU8988S 9.1
Pancreas PATU8988T 8.7
Pancreas PK1 8.6
Pancreas PK45H 8.1
Pancreas PK59 8.6
Pancreas PL45 7.2
Pancreas PSN1 9.2
Pancreas QGP1 7.7
Pancreas SNU213 8.1
Pancreas SNU324 8.9
Pancreas SNU410 8.4
Pancreas SU8686 8.4
Pancreas SUIT2 9.2
Pancreas SW1990 8
Pancreas T3M4 8.4
Pancreas TCCPAN2 7.7
Pancreas YAPC 9.2
Pleura ACCMESO1 8.1
Pleura DM3 8.3
Pleura ISTMES1 8.2
Pleura ISTMES2 7.6
Pleura JL1 8.8
Pleura MPP89 8.3
Pleura MSTO211H 9.2
Pleura NCIH2052 8.7
Pleura NCIH2452 8.6
Pleura NCIH28 8.9
Prostate 22RV1 9
Prostate DU145 8.2
Prostate LNCAPCLONEFGC 8.6
Prostate MDAPCA2B 8.6
Prostate NCIH660 8.9
Prostate PC3 8.9
Prostate VCAP 8.6
Salivary gland A253 8.6
Salivary gland YD15 8.6
Skin A101D 8.8
Skin A2058 8.9
Skin A375 8.8
Skin C32 8.6
Skin CHL1 9.1
Skin CJM 8.6
Skin COLO679 8.3
Skin COLO741 9.1
Skin COLO783 9.7
Skin COLO792 9.4
Skin COLO800 8.2
Skin COLO818 8.5
Skin COLO829 8.3
Skin COLO849 8.6
Skin G361 8.8
Skin GRM 9.7
Skin HMCB 9.3
Skin HS294T 8.4
Skin HS600T 7.9
Skin HS688AT 8.6
Skin HS695T 8.4
Skin HS839T 8.3
Skin HS852T 8.4
Skin HS895T 8.1
Skin HS934T 8.2
Skin HS936T 9.1
Skin HS939T 8.8
Skin HS940T 8.1
Skin HS944T 7.7
Skin HT144 9
Skin IGR1 9.4
Skin IGR37 8.3
Skin IGR39 7.9
Skin IPC298 9.1
Skin K029AX 8.6
Skin LOXIMVI 8.4
Skin MALME3M 8.3
Skin MDAMB435S 8.6
Skin MELHO 9.1
Skin MELJUSO 8.7
Skin MEWO 9.3
Skin RPMI7951 8.6
Skin RVH421 8.9
Skin SH4 9.2
Skin SKMEL1 9.9
Skin SKMEL24 8
Skin SKMEL28 8.4
Skin SKMEL2 8.5
Skin SKMEL30 9
Skin SKMEL31 8.2
Skin SKMEL3 8.7
Skin SKMEL5 8.6
Skin UACC257 8.2
Skin UACC62 9.1
Skin WM115 8.6
Skin WM1799 9
Skin WM2664 8.7
Skin WM793 8.6
Skin WM88 8.6
Skin WM983B 8.5
Small intestine HUTU80 9.5
Soft tissue A204 8.5
Soft tissue G401 9.3
Soft tissue G402 8.4
Soft tissue GCT 8.5
Soft tissue HS729 8.4
Soft tissue HT1080 8.7
Soft tissue KYM1 9.6
Soft tissue MESSA 9.5
Soft tissue RD 9
Soft tissue RH30 9.4
Soft tissue RH41 9.9
Soft tissue RKN 8.6
Soft tissue S117 9
Soft tissue SJRH30 9.3
Soft tissue SKLMS1 8.9
Soft tissue SKUT1 9.6
Soft tissue TE125T 7.9
Soft tissue TE159T 8
Soft tissue TE441T 9.7
Soft tissue TE617T 9.2
Stomach 2313287 7.7
Stomach AGS 9.2
Stomach AZ521 9.2
Stomach ECC10 8.8
Stomach ECC12 7.9
Stomach FU97 8.6
Stomach GCIY 9.2
Stomach GSS 9.6
Stomach GSU 10.7
Stomach HGC27 8.9
Stomach HS746T 8.6
Stomach HUG1N 9.1
Stomach IM95 8.6
Stomach KATOIII 8.4
Stomach KE39 9.3
Stomach LMSU 9.4
Stomach MKN1 8.8
Stomach MKN45 9.7
Stomach MKN74 8.6
Stomach MKN7 8.8
Stomach NCCSTCK140 9.1
Stomach NCIN87 9.1
Stomach NUGC2 9.1
Stomach NUGC3 8.2
Stomach NUGC4 8.2
Stomach OCUM1 8.6
Stomach RERFGC1B 9.1
Stomach SH10TC 8.1
Stomach SNU16 9.8
Stomach SNU1 9.4
Stomach SNU216 9
Stomach SNU520 8.5
Stomach SNU5 9.3
Stomach SNU601 10.1
Stomach SNU620 9
Stomach SNU668 8.8
Stomach SNU719 9.2
Stomach TGBC11TKB 9.6
Thyroid 8305C 8.7
Thyroid 8505C 9
Thyroid BCPAP 8.7
Thyroid BHT101 8.1
Thyroid CAL62 9.1
Thyroid CGTHW1 8.7
Thyroid FTC133 8.1
Thyroid FTC238 8.8
Thyroid ML1 8.1
Thyroid SW579 8.2
Thyroid TT2609C02 8.6
Thyroid TT 7.7
Upper aerodigestive tract BHY 8.3
Upper aerodigestive tract BICR16 8.4
Upper aerodigestive tract BICR18 8.8
Upper aerodigestive tract BICR22 8
Upper aerodigestive tract BICR31 8.6
Upper aerodigestive tract BICR56 7.6
Upper aerodigestive tract BICR6 8.7
Upper aerodigestive tract CAL27 7.7
Upper aerodigestive tract CAL33 7.6
Upper aerodigestive tract DETROIT562 8.5
Upper aerodigestive tract FADU 9.1
Upper aerodigestive tract HS840T 8.7
Upper aerodigestive tract HSC2 8
Upper aerodigestive tract HSC3 8.8
Upper aerodigestive tract HSC4 9
Upper aerodigestive tract PECAPJ15 8.7
Upper aerodigestive tract PECAPJ34CLONEC12 9.2
Upper aerodigestive tract PECAPJ41CLONED2 8.5
Upper aerodigestive tract PECAPJ49 8.7
Upper aerodigestive tract SCC15 8.1
Upper aerodigestive tract SCC25 8.5
Upper aerodigestive tract SCC4 7.8
Upper aerodigestive tract SCC9 8.5
Upper aerodigestive tract SNU1076 8.3
Upper aerodigestive tract SNU1214 8.6
Upper aerodigestive tract SNU46 8.2
Upper aerodigestive tract SNU899 8.2
Upper aerodigestive tract YD10B 8.4
Upper aerodigestive tract YD38 8.1
Upper aerodigestive tract YD8 9.6
Urinary tract 5637 9.7
Urinary tract 639V 9.7
Urinary tract 647V 9.6
Urinary tract BC3C 8.8
Urinary tract BFTC905 9.5
Urinary tract CAL29 9.7
Urinary tract HS172T 8
Urinary tract HT1197 9.3
Urinary tract HT1376 9
Urinary tract J82 8.5
Urinary tract JMSU1 9.7
Urinary tract KMBC2 9.1
Urinary tract KU1919 8.7
Urinary tract RT11284 9.9
Urinary tract RT112 9.2
Urinary tract RT4 9.3
Urinary tract SCABER 7.7
Urinary tract SW1710 8.7
Urinary tract SW780 9.5
Urinary tract T24 9.5
Urinary tract TCCSUP 9.6
Urinary tract UMUC1 8.4
Urinary tract UMUC3 8.7
Urinary tract VMCUB1 7.9
> The Human Protein Atlas (HPA)
 


Tissue Expression Level (TPM)
Adipose tissue 8.4
Adrenal gland 8.1
Appendix 32.8
Bone marrow 14.4
Breast 9.8
Cerebral cortex 22.6
Cervix, uterine 15
Colon 9.6
Duodenum 11.5
Endometrium 21.2
Epididymis 9
Esophagus 16.2
Fallopian tube 22
Gallbladder 14.2
Heart muscle 5.3
Kidney 6.9
Liver 5.8
Lung 19.3
Lymph node 36.3
Ovary 21.5
Pancreas 1.6
Parathyroid gland 27
Placenta 14
Prostate 10.8
Rectum 11.7
Salivary gland 4.7
Seminal vesicle 11.8
Skeletal muscle 6
Skin 26.1
Small intestine 12.3
Smooth muscle 15.7
Spleen 32.3
Stomach 9.7
Testis 22.2
Thyroid gland 13.8
Tonsil 27.3
Urinary bladder 18.3
> Text Mining based Expression
 
PMID Expression Cancer Evidence
22086844OverexpressionAcute Myeloid LeukemiaIn AML cell lines and AML-derived ALDH(hi) (high aldehyde dehydrogenase activity)/CD34(+) cells, the levels of JHDM1B mRNA were significantly higher than in normal ALDH(hi) /CD34(+) cells. Compared to normal ALDH(hi) /CD34(+) cells, JHDM1B gene expression was 1.57- to 1.87-fold higher in AML-derived ALDH(hi) /CD34(+) cells.
28706445OverexpressionMalignant Ovarian NeoplasmWe found that KDM2B expression was gradually increased in ovarian tumors, with the highest expression found in the malignant ovarian tissues, and the differences in KDM2B expression among the different International Federation of Gynecology and Obstetrics stages and pathological grades/types were statistically significant.
Summary
SymbolKDM2B
Namelysine demethylase 2B
Aliases PCCX2; CXXC2; Fbl10; JHDM1B; jumonji C domain-containing histone demethylase 1B; FBXL10; F-box and leucine-r ......
Location12q24.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Somatic copy number alteration in primary tomur tissue
> The Cancer Genome Atlas (TCGA)
 


  Correlation between expression and SCNA as well as percentage of patients in different status.
Cancer Full Name # Sample R P % Loss % Neutral % Gain Status
BLCABladder urothelial carcinoma4040.4354.6e-2017.158.224.8Neutral
BRCABreast invasive carcinoma10750.3452.12e-3119.762.417.9Neutral
CESCCervical and endocervical cancers2920.4282.11e-147.97616.1Neutral
COADColon adenocarcinoma4490.4533.97e-2412.267.919.8Neutral
ESCAEsophageal carcinoma1830.5374.74e-152454.121.9Neutral
GBMGlioblastoma multiforme1470.050.5468.882.38.8Neutral
HNSCHead and Neck squamous cell carcinoma5140.3922.44e-2010.973.715.4Neutral
KIRCKidney renal clear cell carcinoma5250.1690.0001051.17622.9Neutral
KIRPKidney renal papillary cell carcinoma2880.3726.58e-11060.139.9Gain
LAMLAcute Myeloid Leukemia1660.3271.73e-050.699.40Neutral
LGGBrain Lower Grade Glioma5130.2518.27e-0910.7854.3Neutral
LIHCLiver hepatocellular carcinoma3640.2327.4e-061472.813.2Neutral
LUADLung adenocarcinoma5120.4266.17e-242451.824.2Neutral
LUSCLung squamous cell carcinoma4980.4866.51e-3117.558.623.9Neutral
OVOvarian serous cystadenocarcinoma3000.6915.98e-4431.337.731Neutral
PAADPancreatic adenocarcinoma1770.4224.7e-092268.49.6Neutral
PCPGPheochromocytoma and Paraganglioma1620.3144.67e-052.588.98.6Neutral
PRADProstate adenocarcinoma4910.2746.53e-106.387.46.3Neutral
READRectum adenocarcinoma1640.3562.87e-0613.47214.6Neutral
SARCSarcoma2550.6762.23e-3524.755.320Neutral
SKCMSkin Cutaneous Melanoma3670.5431.45e-2922.967.89.3Neutral
STADStomach adenocarcinoma4130.413.3e-181463.922Neutral
TGCTTesticular Germ Cell Tumors1500.2040.01241.342.756Gain
THCAThyroid carcinoma4970.3746.12e-180973Neutral
THYMThymoma1190.3987.47e-065.990.83.4Neutral
UCECUterine Corpus Endometrial Carcinoma5370.4174.68e-2412.376.910.8Neutral
Summary
SymbolKDM2B
Namelysine demethylase 2B
Aliases PCCX2; CXXC2; Fbl10; JHDM1B; jumonji C domain-containing histone demethylase 1B; FBXL10; F-box and leucine-r ......
Location12q24.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Methylation level in the promoter region of CR
> Methylation level in the promoter region of CR
 


  Correlation between expression and methylation as well as differential methylation analysis.
Cancer Full Name R P # N # T Delta beta (T vs N) P value (T vs N) Status
BLCABladder urothelial carcinoma-0.1630.00076317408-0.0410.393NS/NA
BRCABreast invasive carcinoma-0.1310.00011783785-0.0280.0248NS/NA
CESCCervical and endocervical cancers-0.1930.000683306NANANS/NA
COADColon adenocarcinoma-0.1310.0195192970.0935.51e-05NS/NA
ESCAEsophageal carcinoma-0.3361.98e-069185NANANS/NA
GBMGlioblastoma multiforme-0.3810.00185164NANANS/NA
HNSCHead and Neck squamous cell carcinoma-0.1510.000419205220.0031.6e-09NS/NA
KIRCKidney renal clear cell carcinoma-0.2723.58e-0724319-0.3832.35e-19Decreased
KIRPKidney renal papillary cell carcinoma-0.1960.00069623275-0.0230.0517NS/NA
LAMLAcute Myeloid Leukemia-0.1540.04570170NANANS/NA
LGGBrain Lower Grade Glioma-0.1050.01580530NANANS/NA
LIHCLiver hepatocellular carcinoma-0.0650.1874137300.933NS/NA
LUADLung adenocarcinoma-0.3061.15e-11214560.1363.67e-09NS/NA
LUSCLung squamous cell carcinoma-0.2084.78e-058370NANANS/NA
OVOvarian serous cystadenocarcinoma-0.3330.38509NANANS/NA
PAADPancreatic adenocarcinoma-0.2580.0004494179NANANS/NA
PCPGPheochromocytoma and Paraganglioma-0.2450.000763184NANANS/NA
PRADProstate adenocarcinoma-0.1928.79e-06354980.0040.00216NS/NA
READRectum adenocarcinoma-0.1910.0552299NANANS/NA
SARCSarcoma-0.210.0006080263NANANS/NA
SKCMSkin Cutaneous Melanoma-0.2333.14e-071471NANANS/NA
STADStomach adenocarcinoma-0.0820.1160372NANANS/NA
TGCTTesticular Germ Cell Tumors-0.3663.05e-060156NANANS/NA
THCAThyroid carcinoma-0.1540.00027505090.1061.32e-15NS/NA
THYMThymoma-0.4641.07e-072120NANANS/NA
UCECUterine Corpus Endometrial Carcinoma-0.1894.24e-0534431-0.0010.754NS/NA
Summary
SymbolKDM2B
Namelysine demethylase 2B
Aliases PCCX2; CXXC2; Fbl10; JHDM1B; jumonji C domain-containing histone demethylase 1B; FBXL10; F-box and leucine-r ......
Location12q24.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Primary tumor tissue from TCGA
> Normal tumor tissue from HPA
>The Cancer Genome Atlas (TCGA)
 
There is no record.
> The Human Protein Atlas (HPA)
 
There is no antibody staining data.
Summary
SymbolKDM2B
Namelysine demethylase 2B
Aliases PCCX2; CXXC2; Fbl10; JHDM1B; jumonji C domain-containing histone demethylase 1B; FBXL10; F-box and leucine-r ......
Location12q24.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Association between expresson and subtype
> Overall survival analysis based on expression
> Association between expresson and stage
> Association between expresson and grade
> Subtype
 


  Association between expresson and subtype.
Cancer Full Name # Patients P Value (Kruskal-Wallis) Association Source
BLCABladder urothelial carcinoma1280.805NS24476821
BRCABreast invasive carcinoma5213.68e-25Significant23000897
COADColon adenocarcinoma1490.137NS22810696
GBMGlioblastoma multiforme1577.58e-08Significant26824661
HNSCHead and Neck squamous cell carcinoma2791.91e-08Significant25631445
KIRPKidney renal papillary cell carcinoma1610.0101Significant26536169
LGGBrain Lower Grade Glioma5132.42e-16Significant26824661
LUADLung adenocarcinoma2300.00736Significant25079552
LUSCLung squamous cell carcinoma1780.00089Significant22960745
OVOvarian serous cystadenocarcinoma2870.000262Significant21720365
PRADProstate adenocarcinoma3330.133NS26544944
READRectum adenocarcinoma670.988NS22810696
SKCMSkin Cutaneous Melanoma3150.0206Significant26091043
STADStomach adenocarcinoma2771.05e-07Significant25079317
THCAThyroid carcinoma3911.39e-14Significant25417114
UCECUterine Corpus Endometrial Carcinoma2320.278NS23636398
> Overall survival
 

  Overall survival analysis based on expression.
Cancer Full Name # Patients Hazard Ratio P Value (Log Rank Test) Association
BLCABladder urothelial carcinoma405 0.8110.32NS
BRCABreast invasive carcinoma1079 0.8620.523NS
CESCCervical and endocervical cancers291 0.5430.0487Longer
COADColon adenocarcinoma439 1.0670.814NS
ESCAEsophageal carcinoma184 1.430.269NS
GBMGlioblastoma multiforme158 1.0430.873NS
HNSCHead and Neck squamous cell carcinoma518 0.5060.000934Longer
KIRCKidney renal clear cell carcinoma531 2.2130.000405Shorter
KIRPKidney renal papillary cell carcinoma287 0.7440.511NS
LAMLAcute Myeloid Leukemia149 0.5280.0347Longer
LGGBrain Lower Grade Glioma511 0.4910.00364Longer
LIHCLiver hepatocellular carcinoma365 0.6670.141NS
LUADLung adenocarcinoma502 0.8170.326NS
LUSCLung squamous cell carcinoma494 0.7320.108NS
OVOvarian serous cystadenocarcinoma303 1.1380.536NS
PAADPancreatic adenocarcinoma177 0.4450.0139Longer
PCPGPheochromocytoma and Paraganglioma179 1.1220.935NS
PRADProstate adenocarcinoma497 0.8360.816NS
READRectum adenocarcinoma159 0.4070.118NS
SARCSarcoma259 1.8750.0278Shorter
SKCMSkin Cutaneous Melanoma459 1.710.00445Shorter
STADStomach adenocarcinoma388 0.8480.461NS
TGCTTesticular Germ Cell Tumors134 1219008792.8270.238NS
THCAThyroid carcinoma500 0.8890.878NS
THYMThymoma119 0.6780.67NS
UCECUterine Corpus Endometrial Carcinoma543 0.6950.187NS
> Stage
 

  Association between expresson and stage.
Cancer Full Name # Patients R Value (Spearman) P Value (Spearman) Association
BLCABladder urothelial carcinoma406 -0.0640.196NS
BRCABreast invasive carcinoma1071 -0.0280.354NS
CESCCervical and endocervical cancers167 0.0140.857NS
COADColon adenocarcinoma445 -0.0920.0532NS
ESCAEsophageal carcinoma162 -0.0110.885NS
HNSCHead and Neck squamous cell carcinoma448 -0.0490.297NS
KIRCKidney renal clear cell carcinoma531 0.0660.129NS
KIRPKidney renal papillary cell carcinoma260 0.0060.921NS
LIHCLiver hepatocellular carcinoma347 0.0130.814NS
LUADLung adenocarcinoma507 -0.0380.39NS
LUSCLung squamous cell carcinoma497 0.0280.536NS
OVOvarian serous cystadenocarcinoma302 -0.140.0147Lower
PAADPancreatic adenocarcinoma176 -0.0490.515NS
READRectum adenocarcinoma156 -0.1130.16NS
SKCMSkin Cutaneous Melanoma410 -0.0620.209NS
STADStomach adenocarcinoma392 0.0070.886NS
TGCTTesticular Germ Cell Tumors81 0.2210.047Higher
THCAThyroid carcinoma499 -0.0310.489NS
UCECUterine Corpus Endometrial Carcinoma501 -0.0610.171NS
> Grade
 

  Association between expresson and grade.
Cancer Full Name # Patients R Value (Spearman) P Value (Spearman) Association
CESCCervical and endocervical cancers272 0.0610.317NS
HNSCHead and Neck squamous cell carcinoma498 0.0350.439NS
KIRCKidney renal clear cell carcinoma525 0.0840.0542NS
LGGBrain Lower Grade Glioma514 0.0170.701NS
LIHCLiver hepatocellular carcinoma366 0.010.846NS
OVOvarian serous cystadenocarcinoma296 0.1350.0204Higher
PAADPancreatic adenocarcinoma176 0.0340.65NS
STADStomach adenocarcinoma406 0.0650.194NS
UCECUterine Corpus Endometrial Carcinoma534 -0.0030.939NS
Summary
SymbolKDM2B
Namelysine demethylase 2B
Aliases PCCX2; CXXC2; Fbl10; JHDM1B; jumonji C domain-containing histone demethylase 1B; FBXL10; F-box and leucine-r ......
Location12q24.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Targets inferred by reverse engineering method
> Targets identified by ChIP-seq data
> Targets inferred by reverse engineering method
 
> Targets identified by ChIP-seq data
 
Summary
SymbolKDM2B
Namelysine demethylase 2B
Aliases PCCX2; CXXC2; Fbl10; JHDM1B; jumonji C domain-containing histone demethylase 1B; FBXL10; F-box and leucine-r ......
Location12q24.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Drugs from DrugBank database
> Drugs from DrugBank database
 
There is no record for KDM2B.
Summary
SymbolKDM2B
Namelysine demethylase 2B
Aliases PCCX2; CXXC2; Fbl10; JHDM1B; jumonji C domain-containing histone demethylase 1B; FBXL10; F-box and leucine-r ......
Location12q24.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Protein-Protein Interaction Network
> miRNA Regulatory Relationship
> Interactions from Text Mining
> Protein-Protein Interaction Network
 
> miRNA Regulatory Relationship
 
> Interactions from Text Mining
 
There is no record for KDM2B.