CR2Cancer

Summary
Symbol	KDM2B
Name	lysine demethylase 2B
Aliases	PCCX2; CXXC2; Fbl10; JHDM1B; jumonji C domain-containing histone demethylase 1B; FBXL10; F-box and leucine-r ......
Location	12q24.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

[ TOP ]

Domain

PF00646 F-box domain
PF16866 PHD-finger
PF02008 CXXC zinc finger domain

Function

Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification erase	Histone methylation	H3K4me3, H3K36me2	H3K4, H3K36	17994099

> Gene Ontology [ TOP ]
Biological Process	GO:0001558 regulation of cell growth GO:0001654 eye development GO:0001838 embryonic epithelial tube formation GO:0001841 neural tube formation GO:0001843 neural tube closure GO:0003002 regionalization GO:0006482 protein demethylation GO:0006513 protein monoubiquitination GO:0007283 spermatogenesis GO:0007389 pattern specification process GO:0007423 sensory organ development GO:0008214 protein dealkylation GO:0009952 anterior/posterior pattern specification GO:0010390 histone monoubiquitination GO:0014020 primary neural tube formation GO:0016049 cell growth GO:0016331 morphogenesis of embryonic epithelium GO:0016570 histone modification GO:0016574 histone ubiquitination GO:0016577 histone demethylation GO:0019827 stem cell population maintenance GO:0021532 neural tube patterning GO:0021537 telencephalon development GO:0021555 midbrain-hindbrain boundary morphogenesis GO:0021591 ventricular system development GO:0021592 fourth ventricle development GO:0021670 lateral ventricle development GO:0021678 third ventricle development GO:0021903 rostrocaudal neural tube patterning GO:0021915 neural tube development GO:0021993 initiation of neural tube closure GO:0030307 positive regulation of cell growth GO:0030900 forebrain development GO:0030901 midbrain development GO:0030902 hindbrain development GO:0030917 midbrain-hindbrain boundary development GO:0031076 embryonic camera-type eye development GO:0033522 histone H2A ubiquitination GO:0035148 tube formation GO:0035239 tube morphogenesis GO:0035518 histone H2A monoubiquitination GO:0043010 camera-type eye development GO:0043523 regulation of neuron apoptotic process GO:0043524 negative regulation of neuron apoptotic process GO:0045927 positive regulation of growth GO:0048048 embryonic eye morphogenesis GO:0048232 male gamete generation GO:0048562 embryonic organ morphogenesis GO:0048568 embryonic organ development GO:0048592 eye morphogenesis GO:0048593 camera-type eye morphogenesis GO:0048596 embryonic camera-type eye morphogenesis GO:0051402 neuron apoptotic process GO:0060562 epithelial tube morphogenesis GO:0060606 tube closure GO:0061351 neural precursor cell proliferation GO:0070076 histone lysine demethylation GO:0070544 histone H3-K36 demethylation GO:0070988 demethylation GO:0070997 neuron death GO:0072175 epithelial tube formation GO:0090596 sensory organ morphogenesis GO:0098727 maintenance of cell number GO:1901214 regulation of neuron death GO:1901215 negative regulation of neuron death GO:1902459 positive regulation of stem cell population maintenance GO:2000036 regulation of stem cell population maintenance GO:2000177 regulation of neural precursor cell proliferation GO:2000178 negative regulation of neural precursor cell proliferation
Molecular Function	GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding GO:0001046 core promoter sequence-specific DNA binding GO:0001047 core promoter binding GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors GO:0019843 rRNA binding GO:0032451 demethylase activity GO:0032452 histone demethylase activity GO:0051213 dioxygenase activity GO:0051864 histone demethylase activity (H3-K36 specific)
Cellular Component	GO:0031519 PcG protein complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-3214842: HDMs demethylate histones

Summary
Symbol	KDM2B
Name	lysine demethylase 2B
Aliases	PCCX2; CXXC2; Fbl10; JHDM1B; jumonji C domain-containing histone demethylase 1B; FBXL10; F-box and leucine-r ......
Location	12q24.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM4747822	c.1520delA	p.K507fs*66	Deletion - Frameshift	Stomach
COSM3457165	c.2562C>T	p.I854I	Substitution - coding silent	Skin
COSM4386176	c.1273C>T	p.P425S	Substitution - Missense	Large_intestine
COSM3398448	c.1861G>A	p.E621K	Substitution - Missense	Central_nervous_system
COSM5645834	c.686G>T	p.G229V	Substitution - Missense	Oesophagus
COSM1211712	c.1903C>T	p.R635C	Substitution - Missense	Skin
COSM3457174	c.1877C>T	p.P626L	Substitution - Missense	Skin
COSM4596684	c.1696C>T	p.P566S	Substitution - Missense	Upper_aerodigestive_tract
COSM5571569	c.568G>A	p.V190I	Substitution - Missense	Prostate
COSM5753887	c.2913G>A	p.L971L	Substitution - coding silent	Large_intestine
COSM1285698	c.1998A>G	p.P666P	Substitution - coding silent	Autonomic_ganglia
COSM4410866	c.2805delT	p.H936fs*4	Deletion - Frameshift	Kidney
COSM3870947	c.609C>T	p.I203I	Substitution - coding silent	Skin
COSM3870947	c.609C>T	p.I203I	Substitution - coding silent	Skin
COSM5822607	c.1245C>T	p.R415R	Substitution - coding silent	Liver
COSM4694887	c.2444G>A	p.R815Q	Substitution - Missense	Large_intestine
COSM145539	c.1313A>G	p.H438R	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4575114	c.418G>C	p.E140Q	Substitution - Missense	Bone
COSM4384778	c.2643G>T	p.K881N	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM936048	c.329G>A	p.R110K	Substitution - Missense	Endometrium
COSM5989469	c.214G>T	p.D72Y	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM430541	c.2304C>A	p.L768L	Substitution - coding silent	Breast
COSM347815	c.1755G>C	p.L585L	Substitution - coding silent	Lung
COSM4410866	c.2805delT	p.H936fs*4	Deletion - Frameshift	Kidney
COSM4633537	c.1585A>G	p.K529E	Substitution - Missense	Large_intestine
COSM936028	c.2857T>C	p.F953L	Substitution - Missense	Endometrium
COSM5573890	c.1624_1625insC	p.K542fs*76	Insertion - Frameshift	Prostate
COSM4694899	c.1292G>A	p.R431H	Substitution - Missense	Large_intestine
COSM4694883	c.2865C>A	p.A955A	Substitution - coding silent	Large_intestine
COSM4384781	c.2098G>A	p.A700T	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5949193	c.739C>T	p.R247W	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3986706	c.102G>A	p.R34R	Substitution - coding silent	Kidney
COSM4410866	c.2805delT	p.H936fs*4	Deletion - Frameshift	Kidney
COSM3457186	c.619C>T	p.P207S	Substitution - Missense	Skin
COSM936038	c.1810C>A	p.L604M	Substitution - Missense	Endometrium
COSM5618967	c.2091C>T	p.D697D	Substitution - coding silent	Breast
COSM692642	c.2746G>A	p.D916N	Substitution - Missense	Lung
COSM936042	c.1343C>T	p.P448L	Substitution - Missense	Endometrium
COSM3811269	c.196G>A	p.E66K	Substitution - Missense	Breast
COSM4039479	c.1327C>T	p.R443W	Substitution - Missense	Stomach
COSM4039463	c.2860A>G	p.I954V	Substitution - Missense	Stomach
COSM4384787	c.1273C>A	p.P425T	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3670998	c.1623C>T	p.P541P	Substitution - coding silent	Prostate
COSM936030	c.2584C>A	p.L862M	Substitution - Missense	Endometrium
COSM3416558	c.898G>A	p.V300M	Substitution - Missense	Large_intestine
COSM5744476	c.784G>A	p.E262K	Substitution - Missense	Small_intestine
COSM936036	c.2131G>A	p.A711T	Substitution - Missense	Endometrium
COSM1299021	c.1027G>T	p.E343*	Substitution - Nonsense	Urinary_tract
COSM353795	c.1704G>A	p.E568E	Substitution - coding silent	Lung
COSM3870944	c.2011C>T	p.P671S	Substitution - Missense	Skin
COSM1359473	c.2609G>A	p.R870Q	Substitution - Missense	Large_intestine
COSM5046111	c.2143T>C	p.Y715H	Substitution - Missense	Oesophagus
COSM4410866	c.2805delT	p.H936fs*4	Deletion - Frameshift	Kidney
COSM5571569	c.568G>A	p.V190I	Substitution - Missense	Prostate
COSM3752976	c.2487G>A	p.Q829Q	Substitution - coding silent	Large_intestine
COSM4652148	c.2196C>T	p.N732N	Substitution - coding silent	Large_intestine
COSM4482959	c.1575C>T	p.L525L	Substitution - coding silent	Skin
COSM4039473	c.2228G>A	p.R743H	Substitution - Missense	Stomach
COSM4410866	c.2805delT	p.H936fs*4	Deletion - Frameshift	Kidney
COSM4694902	c.1066T>C	p.W356R	Substitution - Missense	Large_intestine
COSM936046	c.393G>T	p.K131N	Substitution - Missense	Endometrium
COSM3368691	c.2714C>A	p.T905N	Substitution - Missense	Thyroid
COSM4852329	c.2866G>A	p.E956K	Substitution - Missense	Cervix
COSM1318048	c.1711_1713delAAG	p.K571delK	Deletion - In frame	Haematopoietic_and_lymphoid_tissue
COSM3457183	c.1275G>A	p.P425P	Substitution - coding silent	Skin
COSM4410866	c.2805delT	p.H936fs*4	Deletion - Frameshift	Kidney
COSM5352132	c.1451G>A	p.W484*	Substitution - Nonsense	Kidney
COSM3457168	c.2300C>T	p.S767F	Substitution - Missense	Skin
COSM4426195	c.2785A>G	p.K929E	Substitution - Missense	Oesophagus
COSM1476252	c.2361G>T	p.L787L	Substitution - coding silent	Breast
COSM1255487	c.2736C>A	p.I912I	Substitution - coding silent	Oesophagus
COSM4694905	c.933C>T	p.D311D	Substitution - coding silent	Large_intestine
COSM3870947	c.609C>T	p.I203I	Substitution - coding silent	Skin
COSM3457168	c.2300C>T	p.S767F	Substitution - Missense	Skin
COSM936032	c.2491C>T	p.R831W	Substitution - Missense	Endometrium
COSM3870947	c.609C>T	p.I203I	Substitution - coding silent	Skin
COSM5659906	c.877-3C>G	p.?	Unknown	Soft_tissue
COSM4694908	c.713C>T	p.A238V	Substitution - Missense	Large_intestine
COSM1628422	c.967A>T	p.M323L	Substitution - Missense	Liver
COSM3457192	c.468G>A	p.L156L	Substitution - coding silent	Skin
COSM5929407	c.1388C>T	p.S463F	Substitution - Missense	Skin
COSM4388262	c.2490G>A	p.M830I	Substitution - Missense	Pancreas
COSM1677420	c.752G>A	p.R251Q	Substitution - Missense	Large_intestine
COSM3980837	c.210C>T	p.G70G	Substitution - coding silent	Ovary
COSM1359479	c.1639G>A	p.D547N	Substitution - Missense	Large_intestine
COSM301574	c.1273_1274CC>AG	p.P425>?	Complex	Large_intestine
COSM5374411	c.166C>T	p.Q56*	Substitution - Nonsense	Skin
COSM5067026	c.1020+9C>A	p.?	Unknown	Large_intestine
COSM936034	c.2391C>T	p.G797G	Substitution - coding silent	Endometrium
COSM3457171	c.2016C>T	p.P672P	Substitution - coding silent	Skin
COSM1299023	c.199G>T	p.E67*	Substitution - Nonsense	Urinary_tract
COSM4694911	c.698C>T	p.A233V	Substitution - Missense	Large_intestine
COSM1628422	c.967A>T	p.M323L	Substitution - Missense	Liver
COSM5578797	c.2850T>A	p.C950*	Substitution - Nonsense	Skin
COSM4039467	c.2526A>G	p.P842P	Substitution - coding silent	Stomach
COSM5557571	c.2046C>T	p.I682I	Substitution - coding silent	Prostate
COSM4039482	c.765C>T	p.C255C	Substitution - coding silent	Stomach
COSM5940281	c.494C>T	p.S165F	Substitution - Missense	Skin
COSM4765947	c.1624_1625insCC	p.K542fs*32	Insertion - Frameshift	Stomach
COSM4384784	c.1831C>T	p.P611S	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3752979	c.1641C>T	p.D547D	Substitution - coding silent	Large_intestine
COSM4596684	c.1696C>T	p.P566S	Substitution - Missense	Upper_aerodigestive_tract
COSM3870947	c.609C>T	p.I203I	Substitution - coding silent	Skin
COSM5469903	c.1933C>T	p.R645W	Substitution - Missense	Large_intestine
COSM2175897	c.1235C>T	p.A412V	Substitution - Missense	Large_intestine
COSM4524783	c.208G>T	p.G70C	Substitution - Missense	Skin
COSM2175947	c.478G>A	p.V160M	Substitution - Missense	Large_intestine
COSM4694893	c.1933_1934insC	p.R645fs*48	Insertion - Frameshift	Large_intestine
COSM5623794	c.2777C>G	p.S926C	Substitution - Missense	Oesophagus
COSM3384099	c.2396C>T	p.S799L	Substitution - Missense	Pancreas
COSM3870941	c.2527+2T>G	p.?	Unknown	Skin
COSM4575110	c.2412G>A	p.S804S	Substitution - coding silent	Bone
COSM3457180	c.1767G>A	p.L589L	Substitution - coding silent	Skin
COSM5903018	c.2366-5C>T	p.?	Unknown	Skin
COSM1582125	c.1724G>A	p.R575H	Substitution - Missense	Stomach
COSM4852137	c.1699G>A	p.E567K	Substitution - Missense	Cervix
COSM1743614	c.409C>T	p.P137S	Substitution - Missense	Biliary_tract
COSM1605670	c.2362C>A	p.P788T	Substitution - Missense	Liver
COSM4842411	c.181G>C	p.E61Q	Substitution - Missense	Cervix
COSM692638	c.521C>T	p.P174L	Substitution - Missense	Lung
COSM1211714	c.1666G>A	p.A556T	Substitution - Missense	Large_intestine
COSM4925964	c.134C>A	p.S45Y	Substitution - Missense	Liver
COSM1359475	c.2170_2171delTG	p.C724fs*14	Deletion - Frameshift	Large_intestine
COSM3792274	c.2411C>T	p.S804L	Substitution - Missense	Urinary_tract
COSM1684353	c.1703_1705delAGA	p.K571delK	Deletion - In frame	Ovary
COSM3457189	c.596C>T	p.P199L	Substitution - Missense	Skin
COSM1677417	c.2305G>T	p.D769Y	Substitution - Missense	Ovary
COSM3398452	c.839G>A	p.R280H	Substitution - Missense	Central_nervous_system
COSM1359477	c.2063G>T	p.S688I	Substitution - Missense	Large_intestine
COSM289704	c.1376C>T	p.S459L	Substitution - Missense	Large_intestine
COSM3935780	c.1549C>T	p.R517C	Substitution - Missense	Oesophagus
COSM1211712	c.1903C>T	p.R635C	Substitution - Missense	Large_intestine
COSM4745555	c.1080_1081GT>AG	p.C361G	Substitution - Missense	Large_intestine
COSM4384775	c.2672C>T	p.T891I	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1162991	c.345G>A	p.E115E	Substitution - coding silent	Pancreas
COSM4385674	c.1387_1388insC	p.G465fs*38	Insertion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM3376151	c.72G>C	p.Q24H	Substitution - Missense	Pancreas
COSM240321	c.450G>T	p.E150D	Substitution - Missense	Prostate
COSM2175825	c.2251T>C	p.S751P	Substitution - Missense	Large_intestine
COSM5480334	c.289G>A	p.G97R	Substitution - Missense	Large_intestine
COSM1211719	c.788G>A	p.C263Y	Substitution - Missense	Oesophagus
COSM5831997	c.1623_1624insC	p.K542fs*76	Insertion - Frameshift	Breast
COSM1359470	c.2777C>T	p.S926F	Substitution - Missense	Large_intestine
COSM1211717	c.1114C>T	p.R372C	Substitution - Missense	Large_intestine
COSM2175959	c.264G>A	p.T88T	Substitution - coding silent	Prostate
COSM5635324	c.1281C>T	p.D427D	Substitution - coding silent	Oesophagus
COSM3870947	c.609C>T	p.I203I	Substitution - coding silent	Skin
COSM1211719	c.788G>A	p.C263Y	Substitution - Missense	Large_intestine
COSM4410866	c.2805delT	p.H936fs*4	Deletion - Frameshift	Kidney
COSM75103	c.2587G>T	p.D863Y	Substitution - Missense	Ovary
COSM4039476	c.2107G>A	p.V703I	Substitution - Missense	Stomach
COSM3764382	c.658G>A	p.A220T	Substitution - Missense	Central_nervous_system
COSM3457165	c.2562C>T	p.I854I	Substitution - coding silent	Skin
COSM3739473	c.831C>G	p.G277G	Substitution - coding silent	Liver
COSM3986703	c.1350G>T	p.E450D	Substitution - Missense	Kidney
COSM5753887	c.2913G>A	p.L971L	Substitution - coding silent	Large_intestine
COSM4650295	c.1522C>T	p.R508W	Substitution - Missense	Large_intestine
COSM4516137	c.525_526GG>AA	p.G176S	Substitution - Missense	Skin
COSM4765944	c.2070_2071insC	p.D692fs*1	Insertion - Frameshift	Stomach
COSM5078071	c.1539C>T	p.N513N	Substitution - coding silent	Large_intestine
COSM3457177	c.1841C>T	p.S614L	Substitution - Missense	Skin
COSM5671016	c.1115G>A	p.R372H	Substitution - Missense	Soft_tissue
COSM4039470	c.2288G>A	p.R763Q	Substitution - Missense	Stomach
COSM3752976	c.2487G>A	p.Q829Q	Substitution - coding silent	Breast
COSM5012630	c.1107A>T	p.K369N	Substitution - Missense	Kidney
COSM5734630	c.2753A>G	p.N918S	Substitution - Missense	Pancreas
COSM4694896	c.1933delC	p.R645fs*37	Deletion - Frameshift	Stomach
COSM2175962	c.187_189delGAG	p.E63delE	Deletion - In frame	Soft_tissue
COSM4747822	c.1520delA	p.K507fs*66	Deletion - Frameshift	Large_intestine
COSM5570113	c.610A>C	p.T204P	Substitution - Missense	Prostate
COSM3811265	c.2893C>A	p.Q965K	Substitution - Missense	Breast
COSM4855986	c.1941G>A	p.L647L	Substitution - coding silent	Cervix
COSM4168963	c.742C>G	p.R248G	Substitution - Missense	Peritoneum
COSM4410866	c.2805delT	p.H936fs*4	Deletion - Frameshift	Kidney
COSM1732389	c.745C>T	p.R249W	Substitution - Missense	Soft_tissue
COSM4388590	c.400A>C	p.T134P	Substitution - Missense	Pancreas
COSM4913993	c.2424C>A	p.S808R	Substitution - Missense	Liver
COSM1637763	c.2400G>A	p.W800*	Substitution - Nonsense	Bone
COSM1211717	c.1114C>T	p.R372C	Substitution - Missense	Bone
COSM1211717	c.1114C>T	p.R372C	Substitution - Missense	Large_intestine
COSM1605670	c.2362C>A	p.P788T	Substitution - Missense	Liver
COSM1677420	c.752G>A	p.R251Q	Substitution - Missense	Large_intestine
COSM5623122	c.2731delG	p.E911fs*29	Deletion - Frameshift	Oesophagus
COSM3703908	c.2140A>T	p.S714C	Substitution - Missense	Liver
COSM2175810	c.2381T>C	p.V794A	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM269424	c.285C>A	p.A95A	Substitution - coding silent	Large_intestine
COSM692640	c.2158G>C	p.D720H	Substitution - Missense	Lung
COSM5374415	c.19G>A	p.E7K	Substitution - Missense	Skin
COSM4620318	c.831C>A	p.G277G	Substitution - coding silent	Large_intestine
COSM355023	c.317G>A	p.R106Q	Substitution - Missense	Lung
COSM936040	c.1557G>A	p.A519A	Substitution - coding silent	Endometrium
COSM430543	c.1576C>T	p.R526W	Substitution - Missense	Breast
COSM4747822	c.1520delA	p.K507fs*66	Deletion - Frameshift	Large_intestine
COSM1188631	c.365C>G	p.S122C	Substitution - Missense	Lung
COSM4410866	c.2805delT	p.H936fs*4	Deletion - Frameshift	Kidney
COSM1211714	c.1666G>A	p.A556T	Substitution - Missense	Large_intestine
COSM2175825	c.2251T>C	p.S751P	Substitution - Missense	Large_intestine
COSM415994	c.1161C>G	p.L387L	Substitution - coding silent	Urinary_tract
COSM4694896	c.1933delC	p.R645fs*37	Deletion - Frameshift	Large_intestine
COSM4880425	c.1569G>A	p.K523K	Substitution - coding silent	Prostate
COSM4694890	c.1943G>A	p.R648Q	Substitution - Missense	Large_intestine
COSM5005897	c.2094T>C	p.D698D	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM3687997	c.746G>A	p.R249Q	Substitution - Missense	Large_intestine
COSM4817690	c.444C>G	p.L148L	Substitution - coding silent	Cervix
COSM5550586	c.1542C>T	p.A514A	Substitution - coding silent	Prostate
COSM6007926	c.2719G>A	p.D907N	Substitution - Missense	Prostate
COSM430545	c.1335C>T	p.Y445Y	Substitution - coding silent	Large_intestine
COSM145539	c.1313A>G	p.H438R	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5244665	c.1244G>C	p.R415P	Substitution - Missense	Liver
COSM110184	c.401C>T	p.T134I	Substitution - Missense	Skin
COSM3986700	c.1351C>T	p.L451L	Substitution - coding silent	Kidney
COSM4694879	c.2919delA	p.K973fs*2	Deletion - Frameshift	Large_intestine
COSM1318050	c.1775A>G	p.E592G	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4384790	c.431A>G	p.K144R	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM936042	c.1343C>T	p.P448L	Substitution - Missense	Skin
COSM1211714	c.1666G>A	p.A556T	Substitution - Missense	Central_nervous_system
COSM3980834	c.2527G>C	p.G843R	Substitution - Missense	Ovary
COSM3398452	c.839G>A	p.R280H	Substitution - Missense	Stomach
COSM3870950	c.321C>T	p.F107F	Substitution - coding silent	Skin

> Text Mining based Variations [ TOP ]
There is no record for KDM2B.

Summary
Symbol	KDM2B
Name	lysine demethylase 2B
Aliases	PCCX2; CXXC2; Fbl10; JHDM1B; jumonji C domain-containing histone demethylase 1B; FBXL10; F-box and leucine-r ......
Location	12q24.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

[ TOP ]

Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
Q8NHM5	474	S	Phosphoserine	-	Yes	p.S474F (cancer: HNSC)
Q8NHM5	477	S	Phosphoserine	-	No	None detected
Q8NHM5	493	T	Phosphothreonine	-	No	None detected
Q8NHM5	497	S	Phosphoserine	-	No	None detected
Q8NHM5	951	S	Phosphoserine	-	No	None detected
Q8NHM5	975	S	Phosphoserine	-	Yes	p.S975L (cancer: SKCM)
Q8NHM5	979	S	Phosphoserine	-	Yes	p.S979N (cancer: PAAD)
Q8NHM5	1018	S	Phosphoserine	-	No	None detected
Q8NHM5	1031	S	Phosphoserine	-	No	None detected

Summary
Symbol	KDM2B
Name	lysine demethylase 2B
Aliases	PCCX2; CXXC2; Fbl10; JHDM1B; jumonji C domain-containing histone demethylase 1B; FBXL10; F-box and leucine-r ......
Location	12q24.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	5.148	5.456	0.289	0.0152	NS
BRCA	Breast invasive carcinoma	112	1100	4.929	5.243	0.4	3.49e-17	NS
CESC	Cervical and endocervical cancers	3	306	4.695	5.6	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	4.753	5.233	0.488	1.97e-14	NS
ESCA	Esophageal carcinoma	11	185	5.095	5.659	0.445	0.0169	NS
GBM	Glioblastoma multiforme	5	166	5.582	5.355	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	5.371	5.234	-0.008	0.929	NS
KIRC	Kidney renal clear cell carcinoma	72	534	4.469	4.876	0.424	3.11e-18	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	4.47	4.831	0.415	3.03e-07	NS
LAML	Acute Myeloid Leukemia	0	173	NA	6.801	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	5.615	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	4.175	4.087	-0.077	0.439	NS
LUAD	Lung adenocarcinoma	59	517	5.089	4.948	-0.092	0.169	NS
LUSC	Lung squamous cell carcinoma	51	501	5.131	5.458	0.363	5.09e-06	NS
OV	Ovarian serous cystadenocarcinoma	0	307	NA	5.758	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	5.112	4.728	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	3.954	4.561	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	4.457	4.297	-0.173	0.00986	NS
READ	Rectum adenocarcinoma	10	167	4.93	5.219	0.448	0.000964	NS
SARC	Sarcoma	2	263	4.475	5.218	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	5.596	5.462	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	5.142	5.479	0.287	0.00185	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	6.682	NA	NA	NA
THCA	Thyroid carcinoma	59	509	4.779	4.587	-0.213	2.94e-05	NS
THYM	Thymoma	2	120	6.145	5.572	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	5.25	5.591	0.348	4.11e-05	NS

> Cancer Cell Line Encyclopedia (CCLE)

[ TOP ]

Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	9.6
Autonomic ganglia	CHP212	9.2
Autonomic ganglia	IMR32	10.4
Autonomic ganglia	KELLY	9.3
Autonomic ganglia	KPNRTBM1	10.1
Autonomic ganglia	KPNSI9S	8.2
Autonomic ganglia	KPNYN	9.8
Autonomic ganglia	MHHNB11	9.5
Autonomic ganglia	NB1	10.2
Autonomic ganglia	NH6	10
Autonomic ganglia	SHSY5Y	9.2
Autonomic ganglia	SIMA	9.6
Autonomic ganglia	SKNAS	9.6
Autonomic ganglia	SKNBE2	9.9
Autonomic ganglia	SKNDZ	10.3
Autonomic ganglia	SKNFI	9.7
Autonomic ganglia	SKNSH	9.4
Biliary tract	HUCCT1	8.5
Biliary tract	HUH28	8.2
Biliary tract	SNU1079	8.8
Biliary tract	SNU1196	8.5
Biliary tract	SNU245	9.3
Biliary tract	SNU308	8.3
Biliary tract	SNU478	9.6
Bone	143B	8.6
Bone	A673	8.9
Bone	CADOES1	9.8
Bone	CAL78	8.3
Bone	G292CLONEA141B1	9.2
Bone	HOS	8.9
Bone	HS706T	8.5
Bone	HS737T	8.4
Bone	HS819T	7.7
Bone	HS821T	8.4
Bone	HS822T	8.3
Bone	HS863T	8.1
Bone	HS870T	8.2
Bone	HS888T	9
Bone	MG63	8.9
Bone	MHHES1	9.4
Bone	OUMS27	8.9
Bone	RDES	10.4
Bone	SJSA1	8.3
Bone	SKES1	10.5
Bone	SKNMC	10.1
Bone	SW1353	8.8
Bone	T173	7.9
Bone	TC71	9.2
Bone	U2OS	8.8
Breast	AU565	8.5
Breast	BT20	8.2
Breast	BT474	9.6
Breast	BT483	9.6
Breast	BT549	8.1
Breast	CAL120	8.3
Breast	CAL148	10.5
Breast	CAL51	9.6
Breast	CAL851	8.4
Breast	CAMA1	8.4
Breast	DU4475	9.2
Breast	EFM192A	8.4
Breast	EFM19	9.9
Breast	EVSAT	9.2
Breast	HCC1143	8.2
Breast	HCC1187	10
Breast	HCC1395	8.2
Breast	HCC1419	8.8
Breast	HCC1428	9.1
Breast	HCC1500	9.6
Breast	HCC1569	8.6
Breast	HCC1599	9.9
Breast	HCC1806	9.4
Breast	HCC1937	8.5
Breast	HCC1954	8.7
Breast	HCC202	9.4
Breast	HCC2157	9
Breast	HCC2218	8.7
Breast	HCC38	9.1
Breast	HCC70	8.7
Breast	HDQP1	9
Breast	HMC18	8.8
Breast	HS274T	7.8
Breast	HS281T	8.5
Breast	HS343T	8.7
Breast	HS578T	8.5
Breast	HS606T	8.1
Breast	HS739T	8.4
Breast	HS742T	8
Breast	JIMT1	9.9
Breast	KPL1	9.3
Breast	MCF7	8.7
Breast	MDAMB134VI	9.3
Breast	MDAMB157	8.9
Breast	MDAMB175VII	7.9
Breast	MDAMB231	8.6
Breast	MDAMB361	9.4
Breast	MDAMB415	6.7
Breast	MDAMB436	9.3
Breast	MDAMB453	8.7
Breast	MDAMB468	8.4
Breast	SKBR3	8.3
Breast	T47D	9.3
Breast	UACC812	9
Breast	UACC893	8.6
Breast	YMB1	8.9
Breast	ZR751	8.4
Breast	ZR7530	8.2
Central nervous system	1321N1	9
Central nervous system	42MGBA	8.9
Central nervous system	8MGBA	8.2
Central nervous system	A172	8.6
Central nervous system	AM38	9
Central nervous system	BECKER	8.6
Central nervous system	CAS1	8.6
Central nervous system	CCFSTTG1	8.9
Central nervous system	D283MED	9.4
Central nervous system	D341MED	8.8
Central nervous system	DAOY	9.1
Central nervous system	DBTRG05MG	8.5
Central nervous system	DKMG	8.7
Central nervous system	GAMG	8.4
Central nervous system	GB1	9.4
Central nervous system	GI1	8.6
Central nervous system	GMS10	7.9
Central nervous system	GOS3	8.5
Central nervous system	H4	8.5
Central nervous system	HS683	8.4
Central nervous system	KALS1	9.4
Central nervous system	KG1C	8.9
Central nervous system	KNS42	8.3
Central nervous system	KNS60	8.6
Central nervous system	KNS81	8.4
Central nervous system	KS1	8.6
Central nervous system	LN18	8.9
Central nervous system	LN229	8.2
Central nervous system	M059K	7.9
Central nervous system	MOGGCCM	8.1
Central nervous system	MOGGUVW	8.4
Central nervous system	NMCG1	8.2
Central nervous system	ONS76	8.1
Central nervous system	SF126	8.7
Central nervous system	SF295	8.7
Central nervous system	SNB19	8.5
Central nervous system	SNU1105	8.5
Central nervous system	SNU201	8.7
Central nervous system	SNU466	9.2
Central nervous system	SNU489	8.5
Central nervous system	SNU626	8.5
Central nervous system	SNU738	9.1
Central nervous system	SW1088	8.5
Central nervous system	SW1783	8.2
Central nervous system	T98G	8.3
Central nervous system	TM31	8.6
Central nervous system	U118MG	8.8
Central nervous system	U138MG	9
Central nervous system	U251MG	8
Central nervous system	U87MG	8.5
Central nervous system	YH13	8.1
Central nervous system	YKG1	9.1
Endometrium	AN3CA	7.4
Endometrium	COLO684	9
Endometrium	EFE184	8
Endometrium	EN	8.7
Endometrium	ESS1	8.1
Endometrium	HEC108	9.1
Endometrium	HEC151	8.7
Endometrium	HEC1A	8.2
Endometrium	HEC1B	9
Endometrium	HEC251	8.7
Endometrium	HEC265	8.7
Endometrium	HEC50B	8.4
Endometrium	HEC59	9.2
Endometrium	HEC6	9.1
Endometrium	ISHIKAWAHERAKLIO02ER	9.3
Endometrium	JHUEM1	8.5
Endometrium	JHUEM2	9.6
Endometrium	JHUEM3	8.8
Endometrium	KLE	8.3
Endometrium	MFE280	9.4
Endometrium	MFE296	9.3
Endometrium	MFE319	7.8
Endometrium	RL952	9.3
Endometrium	SNGM	8.6
Endometrium	SNU1077	8.5
Endometrium	SNU685	9.3
Endometrium	TEN	8.9
Haematopoietic and lymphoid	697	10.6
Haematopoietic and lymphoid	A3KAW	9.7
Haematopoietic and lymphoid	A4FUK	9.6
Haematopoietic and lymphoid	ALLSIL	10.8
Haematopoietic and lymphoid	AML193	9.6
Haematopoietic and lymphoid	AMO1	9.4
Haematopoietic and lymphoid	BCP1	9.6
Haematopoietic and lymphoid	BDCM	9.8
Haematopoietic and lymphoid	BL41	10.5
Haematopoietic and lymphoid	BL70	10.7
Haematopoietic and lymphoid	BV173	10
Haematopoietic and lymphoid	CA46	9.8
Haematopoietic and lymphoid	CI1	10.3
Haematopoietic and lymphoid	CMK115	9.6
Haematopoietic and lymphoid	CMK86	10.2
Haematopoietic and lymphoid	CMK	10
Haematopoietic and lymphoid	CMLT1	10.2
Haematopoietic and lymphoid	COLO775	9.2
Haematopoietic and lymphoid	DAUDI	9.8
Haematopoietic and lymphoid	DB	10.2
Haematopoietic and lymphoid	DEL	8.3
Haematopoietic and lymphoid	DND41	10.9
Haematopoietic and lymphoid	DOHH2	10.7
Haematopoietic and lymphoid	EB1	10.2
Haematopoietic and lymphoid	EB2	9.7
Haematopoietic and lymphoid	EHEB	10.8
Haematopoietic and lymphoid	EJM	9.8
Haematopoietic and lymphoid	EM2	10.1
Haematopoietic and lymphoid	EOL1	10.9
Haematopoietic and lymphoid	F36P	9.7
Haematopoietic and lymphoid	GA10	10.3
Haematopoietic and lymphoid	GDM1	9.8
Haematopoietic and lymphoid	GRANTA519	10.4
Haematopoietic and lymphoid	HDLM2	9.5
Haematopoietic and lymphoid	HDMYZ	8.1
Haematopoietic and lymphoid	HEL9217	9.9
Haematopoietic and lymphoid	HEL	9.7
Haematopoietic and lymphoid	HH	8.9
Haematopoietic and lymphoid	HL60	9.8
Haematopoietic and lymphoid	HPBALL	10.8
Haematopoietic and lymphoid	HS604T	7.9
Haematopoietic and lymphoid	HS611T	10.1
Haematopoietic and lymphoid	HS616T	7.9
Haematopoietic and lymphoid	HS751T	8.5
Haematopoietic and lymphoid	HT	10
Haematopoietic and lymphoid	HTK	8.9
Haematopoietic and lymphoid	HUNS1	10.3
Haematopoietic and lymphoid	HUT102	9.1
Haematopoietic and lymphoid	HUT78	9.6
Haematopoietic and lymphoid	JEKO1	11.1
Haematopoietic and lymphoid	JK1	9.4
Haematopoietic and lymphoid	JM1	10.3
Haematopoietic and lymphoid	JURKAT	10.1
Haematopoietic and lymphoid	JURLMK1	10
Haematopoietic and lymphoid	JVM2	10.6
Haematopoietic and lymphoid	JVM3	11.2
Haematopoietic and lymphoid	K562	8.7
Haematopoietic and lymphoid	KARPAS299	9
Haematopoietic and lymphoid	KARPAS422	10.5
Haematopoietic and lymphoid	KARPAS620	9.9
Haematopoietic and lymphoid	KASUMI1	10.2
Haematopoietic and lymphoid	KASUMI2	10.9
Haematopoietic and lymphoid	KASUMI6	10.4
Haematopoietic and lymphoid	KCL22	9.6
Haematopoietic and lymphoid	KE37	10.4
Haematopoietic and lymphoid	KE97	10.1
Haematopoietic and lymphoid	KG1	10
Haematopoietic and lymphoid	KHM1B	9.4
Haematopoietic and lymphoid	KIJK	8.6
Haematopoietic and lymphoid	KMH2	11.7
Haematopoietic and lymphoid	KMM1	9.3
Haematopoietic and lymphoid	KMS11	9.1
Haematopoietic and lymphoid	KMS12BM	10.1
Haematopoietic and lymphoid	KMS18	10.1
Haematopoietic and lymphoid	KMS20	10.4
Haematopoietic and lymphoid	KMS21BM	9.1
Haematopoietic and lymphoid	KMS26	8.6
Haematopoietic and lymphoid	KMS27	8.9
Haematopoietic and lymphoid	KMS28BM	8.7
Haematopoietic and lymphoid	KMS34	9
Haematopoietic and lymphoid	KO52	10.1
Haematopoietic and lymphoid	KOPN8	11.3
Haematopoietic and lymphoid	KU812	9.6
Haematopoietic and lymphoid	KYO1	9.5
Haematopoietic and lymphoid	L1236	8.1
Haematopoietic and lymphoid	L363	9
Haematopoietic and lymphoid	L428	8.2
Haematopoietic and lymphoid	L540	9.3
Haematopoietic and lymphoid	LAMA84	9.6
Haematopoietic and lymphoid	LOUCY	10.4
Haematopoietic and lymphoid	LP1	8.8
Haematopoietic and lymphoid	M07E	9.9
Haematopoietic and lymphoid	MC116	10.6
Haematopoietic and lymphoid	ME1	10.8
Haematopoietic and lymphoid	MEC1	10.3
Haematopoietic and lymphoid	MEC2	10.5
Haematopoietic and lymphoid	MEG01	9.6
Haematopoietic and lymphoid	MHHCALL2	10.4
Haematopoietic and lymphoid	MHHCALL3	11.2
Haematopoietic and lymphoid	MHHCALL4	11
Haematopoietic and lymphoid	MINO	10.9
Haematopoietic and lymphoid	MJ	9.7
Haematopoietic and lymphoid	MM1S	8.3
Haematopoietic and lymphoid	MOLM13	10.3
Haematopoietic and lymphoid	MOLM16	10
Haematopoietic and lymphoid	MOLM6	10.1
Haematopoietic and lymphoid	MOLP2	9.4
Haematopoietic and lymphoid	MOLP8	9.5
Haematopoietic and lymphoid	MOLT13	10.8
Haematopoietic and lymphoid	MOLT16	10.4
Haematopoietic and lymphoid	MOLT4	9.8
Haematopoietic and lymphoid	MONOMAC1	10.8
Haematopoietic and lymphoid	MONOMAC6	10.1
Haematopoietic and lymphoid	MOTN1	10.1
Haematopoietic and lymphoid	MUTZ5	11
Haematopoietic and lymphoid	MV411	10.8
Haematopoietic and lymphoid	NALM19	10.5
Haematopoietic and lymphoid	NALM1	10.8
Haematopoietic and lymphoid	NALM6	10.7
Haematopoietic and lymphoid	NAMALWA	10.3
Haematopoietic and lymphoid	NB4	10.9
Haematopoietic and lymphoid	NCIH929	8.3
Haematopoietic and lymphoid	NCO2	9.1
Haematopoietic and lymphoid	NOMO1	10.3
Haematopoietic and lymphoid	NUDHL1	10.5
Haematopoietic and lymphoid	NUDUL1	10.5
Haematopoietic and lymphoid	OCIAML2	11
Haematopoietic and lymphoid	OCIAML3	9.9
Haematopoietic and lymphoid	OCIAML5	11.1
Haematopoietic and lymphoid	OCILY10	10.3
Haematopoietic and lymphoid	OCILY19	10.9
Haematopoietic and lymphoid	OCILY3	11.2
Haematopoietic and lymphoid	OCIM1	8.8
Haematopoietic and lymphoid	OPM2	8.8
Haematopoietic and lymphoid	P12ICHIKAWA	10.5
Haematopoietic and lymphoid	P31FUJ	9.6
Haematopoietic and lymphoid	P3HR1	10.1
Haematopoietic and lymphoid	PCM6	8.4
Haematopoietic and lymphoid	PEER	10.2
Haematopoietic and lymphoid	PF382	10.1
Haematopoietic and lymphoid	PFEIFFER	10.7
Haematopoietic and lymphoid	PL21	10
Haematopoietic and lymphoid	RAJI	10.4
Haematopoietic and lymphoid	RCHACV	11.3
Haematopoietic and lymphoid	REC1	10.4
Haematopoietic and lymphoid	REH	10.2
Haematopoietic and lymphoid	RI1	11.4
Haematopoietic and lymphoid	RL	9.9
Haematopoietic and lymphoid	RPMI8226	9
Haematopoietic and lymphoid	RPMI8402	10.6
Haematopoietic and lymphoid	RS411	10.4
Haematopoietic and lymphoid	SEM	10.6
Haematopoietic and lymphoid	SET2	9.9
Haematopoietic and lymphoid	SIGM5	10.5
Haematopoietic and lymphoid	SKM1	9.7
Haematopoietic and lymphoid	SKMM2	9.3
Haematopoietic and lymphoid	SR786	9
Haematopoietic and lymphoid	ST486	10.2
Haematopoietic and lymphoid	SUDHL10	10.4
Haematopoietic and lymphoid	SUDHL1	8.2
Haematopoietic and lymphoid	SUDHL4	10.8
Haematopoietic and lymphoid	SUDHL5	10.4
Haematopoietic and lymphoid	SUDHL6	10.3
Haematopoietic and lymphoid	SUDHL8	9.8
Haematopoietic and lymphoid	SUPB15	10.4
Haematopoietic and lymphoid	SUPHD1	8
Haematopoietic and lymphoid	SUPM2	8.6
Haematopoietic and lymphoid	SUPT11	10.8
Haematopoietic and lymphoid	SUPT1	9.6
Haematopoietic and lymphoid	TALL1	10.5
Haematopoietic and lymphoid	TF1	9.1
Haematopoietic and lymphoid	THP1	10.7
Haematopoietic and lymphoid	TO175T	8.3
Haematopoietic and lymphoid	TOLEDO	10.3
Haematopoietic and lymphoid	U266B1	8.9
Haematopoietic and lymphoid	U937	9.8
Haematopoietic and lymphoid	UT7	9.6
Haematopoietic and lymphoid	WSUDLCL2	10.3
Kidney	769P	7.8
Kidney	786O	8.6
Kidney	A498	8
Kidney	A704	8.5
Kidney	ACHN	8.5
Kidney	BFTC909	7.7
Kidney	CAKI1	8.4
Kidney	CAKI2	8.6
Kidney	CAL54	9.2
Kidney	KMRC1	8.1
Kidney	KMRC20	8.2
Kidney	KMRC2	8.5
Kidney	KMRC3	7.9
Kidney	OSRC2	9.1
Kidney	RCC10RGB	8.1
Kidney	SNU1272	8.6
Kidney	SNU349	8.7
Kidney	TUHR10TKB	9.9
Kidney	TUHR14TKB	7.7
Kidney	TUHR4TKB	8.8
Kidney	VMRCRCW	7.3
Kidney	VMRCRCZ	7.5
Large intestine	C2BBE1	9
Large intestine	CCK81	9.1
Large intestine	CL11	9.4
Large intestine	CL14	9.1
Large intestine	CL34	8.7
Large intestine	CL40	9.7
Large intestine	COLO205	8.5
Large intestine	COLO320	10.5
Large intestine	COLO678	10.4
Large intestine	CW2	9.3
Large intestine	DLD1	8.6
Large intestine	GP2D	10.2
Large intestine	HCC56	9.2
Large intestine	HCT116	9.4
Large intestine	HCT15	8.4
Large intestine	HS675T	8.2
Large intestine	HS698T	7.8
Large intestine	HT115	9.1
Large intestine	HT29	8.1
Large intestine	HT55	9.1
Large intestine	KM12	8.3
Large intestine	LOVO	9.6
Large intestine	LS1034	8.6
Large intestine	LS123	9.4
Large intestine	LS180	9
Large intestine	LS411N	8.8
Large intestine	LS513	8.7
Large intestine	MDST8	9.7
Large intestine	NCIH508	8.4
Large intestine	NCIH716	8.4
Large intestine	NCIH747	8.5
Large intestine	OUMS23	9
Large intestine	RCM1	8.4
Large intestine	RKO	9.3
Large intestine	SKCO1	9.5
Large intestine	SNU1040	9.6
Large intestine	SNU1197	7.9
Large intestine	SNU175	9.2
Large intestine	SNU283	9.2
Large intestine	SNU407	9.3
Large intestine	SNU503	9.2
Large intestine	SNU61	9.7
Large intestine	SNU81	8.5
Large intestine	SNUC1	9.5
Large intestine	SNUC2A	9.1
Large intestine	SNUC4	9.8
Large intestine	SNUC5	9.1
Large intestine	SW1116	8.7
Large intestine	SW1417	8.6
Large intestine	SW1463	9.3
Large intestine	SW403	9.1
Large intestine	SW480	8
Large intestine	SW48	9.2
Large intestine	SW620	8.8
Large intestine	SW837	9.3
Large intestine	SW948	9.1
Large intestine	T84	9.6
Liver	ALEXANDERCELLS	8.6
Liver	C3A	9
Liver	HEP3B217	9.3
Liver	HEPG2	9.3
Liver	HLE	7.7
Liver	HLF	8
Liver	HUH1	9.4
Liver	HUH6	9.7
Liver	HUH7	8.3
Liver	JHH1	7.9
Liver	JHH2	7.8
Liver	JHH4	8.2
Liver	JHH5	8.7
Liver	JHH6	8.7
Liver	JHH7	9.2
Liver	LI7	9.4
Liver	PLCPRF5	9
Liver	SKHEP1	9
Liver	SNU182	8.4
Liver	SNU387	8.9
Liver	SNU398	9.6
Liver	SNU423	8.5
Liver	SNU449	8.7
Liver	SNU475	8.3
Liver	SNU761	8.2
Liver	SNU878	8.4
Liver	SNU886	8.4
Lung	A549	8.4
Lung	ABC1	8.2
Lung	BEN	8.1
Lung	CAL12T	9.1
Lung	CALU1	8
Lung	CALU3	8.1
Lung	CALU6	8.7
Lung	CHAGOK1	8.7
Lung	COLO668	9.9
Lung	COLO699	9.6
Lung	CORL105	8.8
Lung	CORL23	9
Lung	CORL24	9.9
Lung	CORL279	9.2
Lung	CORL311	10.6
Lung	CORL47	10.2
Lung	CORL51	9.9
Lung	CORL88	9.5
Lung	CORL95	9.8
Lung	CPCN	9.3
Lung	DMS114	9.2
Lung	DMS153	8.1
Lung	DMS273	9.8
Lung	DMS454	8.8
Lung	DMS53	8.6
Lung	DMS79	9.6
Lung	DV90	6.8
Lung	EBC1	9
Lung	EPLC272H	8.1
Lung	HARA	9
Lung	HCC1171	8.3
Lung	HCC1195	9.2
Lung	HCC15	8.6
Lung	HCC2279	8.2
Lung	HCC2935	7.5
Lung	HCC33	9.7
Lung	HCC366	8.4
Lung	HCC4006	8.4
Lung	HCC44	7.6
Lung	HCC78	8.2
Lung	HCC827	9.1
Lung	HCC95	8.3
Lung	HLC1	9.2
Lung	HLFA	8.1
Lung	HS229T	8.7
Lung	HS618T	8.6
Lung	IALM	9.2
Lung	KNS62	8.2
Lung	LC1F	8.9
Lung	LC1SQSF	8.3
Lung	LCLC103H	8.7
Lung	LCLC97TM1	9.1
Lung	LK2	9.6
Lung	LOUNH91	8
Lung	LU65	8.5
Lung	LU99	10.7
Lung	LUDLU1	8.5
Lung	LXF289	8.5
Lung	MORCPR	8.5
Lung	NCIH1048	9.7
Lung	NCIH1092	9
Lung	NCIH1105	10.4
Lung	NCIH1155	9
Lung	NCIH1184	9.3
Lung	NCIH1299	8.2
Lung	NCIH1339	9.2
Lung	NCIH1341	9
Lung	NCIH1355	8.3
Lung	NCIH1373	8.4
Lung	NCIH1385	8.9
Lung	NCIH1395	8
Lung	NCIH1435	9
Lung	NCIH1436	9.7
Lung	NCIH1437	8.8
Lung	NCIH146	9.2
Lung	NCIH1563	8
Lung	NCIH1568	9.8
Lung	NCIH1573	8.3
Lung	NCIH1581	9.4
Lung	NCIH1618	9.3
Lung	NCIH1623	8.5
Lung	NCIH1648	8.7
Lung	NCIH1650	8.5
Lung	NCIH1651	8.4
Lung	NCIH1666	7.9
Lung	NCIH1693	8.5
Lung	NCIH1694	9
Lung	NCIH1703	8
Lung	NCIH1734	8.5
Lung	NCIH1755	8.5
Lung	NCIH1781	7.2
Lung	NCIH1792	9.3
Lung	NCIH1793	8.2
Lung	NCIH1836	9.7
Lung	NCIH1838	8.3
Lung	NCIH1869	8.6
Lung	NCIH1876	10.2
Lung	NCIH1915	8.6
Lung	NCIH1930	8.6
Lung	NCIH1944	8.3
Lung	NCIH1963	9.6
Lung	NCIH196	8
Lung	NCIH1975	7.7
Lung	NCIH2009	8.4
Lung	NCIH2023	8
Lung	NCIH2029	9.2
Lung	NCIH2030	7.3
Lung	NCIH2066	8.7
Lung	NCIH2081	9.4
Lung	NCIH2085	8.7
Lung	NCIH2087	8.8
Lung	NCIH209	8.6
Lung	NCIH2106	9.2
Lung	NCIH2110	9
Lung	NCIH211	9.8
Lung	NCIH2122	8
Lung	NCIH2126	8.9
Lung	NCIH2141	10.1
Lung	NCIH2170	8.3
Lung	NCIH2171	9.5
Lung	NCIH2172	8.7
Lung	NCIH2196	8.2
Lung	NCIH2227	9.5
Lung	NCIH2228	8.5
Lung	NCIH226	7.9
Lung	NCIH2286	9.3
Lung	NCIH2291	8.4
Lung	NCIH2342	8.7
Lung	NCIH2347	8.3
Lung	NCIH23	8.8
Lung	NCIH2405	8.2
Lung	NCIH2444	7.5
Lung	NCIH292	8.5
Lung	NCIH322	7.7
Lung	NCIH3255	8.2
Lung	NCIH358	8.3
Lung	NCIH441	7
Lung	NCIH446	9.4
Lung	NCIH460	9
Lung	NCIH510	9.6
Lung	NCIH520	9.1
Lung	NCIH522	8.8
Lung	NCIH524	8.9
Lung	NCIH526	10.1
Lung	NCIH596	8
Lung	NCIH647	8.6
Lung	NCIH650	8.5
Lung	NCIH661	8.7
Lung	NCIH69	9.8
Lung	NCIH727	8.7
Lung	NCIH810	8.3
Lung	NCIH82	9.5
Lung	NCIH838	8.3
Lung	NCIH841	9.8
Lung	NCIH854	8.5
Lung	NCIH889	9.6
Lung	PC14	8.3
Lung	RERFLCAD1	8.5
Lung	RERFLCAD2	8.3
Lung	RERFLCAI	8
Lung	RERFLCKJ	8.3
Lung	RERFLCMS	8
Lung	RERFLCSQ1	8.2
Lung	SBC5	8.7
Lung	SCLC21H	9.8
Lung	SHP77	9.4
Lung	SKLU1	7.9
Lung	SKMES1	8.3
Lung	SQ1	8.2
Lung	SW1271	8
Lung	SW1573	8.6
Lung	SW900	8.2
Lung	VMRCLCD	9.3
Lung	VMRCLCP	9.8
Oesophagus	COLO680N	8.6
Oesophagus	ECGI10	8.6
Oesophagus	KYSE140	8.3
Oesophagus	KYSE150	8.3
Oesophagus	KYSE180	8.6
Oesophagus	KYSE270	9.2
Oesophagus	KYSE30	7.5
Oesophagus	KYSE410	8.3
Oesophagus	KYSE450	8.8
Oesophagus	KYSE510	8.3
Oesophagus	KYSE520	8.4
Oesophagus	KYSE70	8.3
Oesophagus	OE19	7.9
Oesophagus	OE33	7.8
Oesophagus	TE10	8.8
Oesophagus	TE11	8.6
Oesophagus	TE14	9.4
Oesophagus	TE15	8.5
Oesophagus	TE1	8.7
Oesophagus	TE4	8.5
Oesophagus	TE5	8.8
Oesophagus	TE6	8.6
Oesophagus	TE8	9.1
Oesophagus	TE9	8.6
Oesophagus	TT	8.7
Ovary	59M	7.9
Ovary	A2780	9.6
Ovary	CAOV3	8.6
Ovary	CAOV4	9.1
Ovary	COLO704	8.7
Ovary	COV318	8
Ovary	COV362	7.9
Ovary	COV434	9.3
Ovary	COV504	9
Ovary	COV644	8.4
Ovary	EFO21	8.9
Ovary	EFO27	9
Ovary	ES2	8.4
Ovary	FUOV1	8.6
Ovary	HEYA8	7.9
Ovary	HS571T	7.5
Ovary	IGROV1	8.6
Ovary	JHOC5	8.5
Ovary	JHOM1	8.8
Ovary	JHOM2B	9.4
Ovary	JHOS2	7.9
Ovary	JHOS4	9.1
Ovary	KURAMOCHI	8.5
Ovary	MCAS	8.2
Ovary	NIHOVCAR3	8.6
Ovary	OAW28	9.1
Ovary	OAW42	9.2
Ovary	OC314	7.5
Ovary	OC316	7.6
Ovary	ONCODG1	9.1
Ovary	OV56	7.6
Ovary	OV7	8.7
Ovary	OV90	8.9
Ovary	OVCAR4	7.8
Ovary	OVCAR8	8.7
Ovary	OVISE	8.3
Ovary	OVK18	9.3
Ovary	OVKATE	7.9
Ovary	OVMANA	9.3
Ovary	OVSAHO	7.9
Ovary	OVTOKO	8
Ovary	RMGI	7.7
Ovary	RMUGS	9.8
Ovary	SKOV3	9.2
Ovary	SNU119	8.6
Ovary	SNU840	9.5
Ovary	SNU8	8.6
Ovary	TOV112D	9.9
Ovary	TOV21G	8.6
Ovary	TYKNU	8.4
Pancreas	ASPC1	7.9
Pancreas	BXPC3	9.3
Pancreas	CAPAN1	8.4
Pancreas	CAPAN2	7
Pancreas	CFPAC1	8.2
Pancreas	DANG	8.9
Pancreas	HPAC	8.1
Pancreas	HPAFII	8.4
Pancreas	HS766T	7.9
Pancreas	HUPT3	8.4
Pancreas	HUPT4	9.3
Pancreas	KCIMOH1	8
Pancreas	KLM1	8.8
Pancreas	KP2	8
Pancreas	KP3	7.5
Pancreas	KP4	8.8
Pancreas	L33	8.1
Pancreas	MIAPACA2	8.1
Pancreas	PANC0203	8.3
Pancreas	PANC0213	7.7
Pancreas	PANC0327	8
Pancreas	PANC0403	7.7
Pancreas	PANC0504	8.3
Pancreas	PANC0813	8.2
Pancreas	PANC1005	7.3
Pancreas	PANC1	8.4
Pancreas	PATU8902	7.6
Pancreas	PATU8988S	9.1
Pancreas	PATU8988T	8.7
Pancreas	PK1	8.6
Pancreas	PK45H	8.1
Pancreas	PK59	8.6
Pancreas	PL45	7.2
Pancreas	PSN1	9.2
Pancreas	QGP1	7.7
Pancreas	SNU213	8.1
Pancreas	SNU324	8.9
Pancreas	SNU410	8.4
Pancreas	SU8686	8.4
Pancreas	SUIT2	9.2
Pancreas	SW1990	8
Pancreas	T3M4	8.4
Pancreas	TCCPAN2	7.7
Pancreas	YAPC	9.2
Pleura	ACCMESO1	8.1
Pleura	DM3	8.3
Pleura	ISTMES1	8.2
Pleura	ISTMES2	7.6
Pleura	JL1	8.8
Pleura	MPP89	8.3
Pleura	MSTO211H	9.2
Pleura	NCIH2052	8.7
Pleura	NCIH2452	8.6
Pleura	NCIH28	8.9
Prostate	22RV1	9
Prostate	DU145	8.2
Prostate	LNCAPCLONEFGC	8.6
Prostate	MDAPCA2B	8.6
Prostate	NCIH660	8.9
Prostate	PC3	8.9
Prostate	VCAP	8.6
Salivary gland	A253	8.6
Salivary gland	YD15	8.6
Skin	A101D	8.8
Skin	A2058	8.9
Skin	A375	8.8
Skin	C32	8.6
Skin	CHL1	9.1
Skin	CJM	8.6
Skin	COLO679	8.3
Skin	COLO741	9.1
Skin	COLO783	9.7
Skin	COLO792	9.4
Skin	COLO800	8.2
Skin	COLO818	8.5
Skin	COLO829	8.3
Skin	COLO849	8.6
Skin	G361	8.8
Skin	GRM	9.7
Skin	HMCB	9.3
Skin	HS294T	8.4
Skin	HS600T	7.9
Skin	HS688AT	8.6
Skin	HS695T	8.4
Skin	HS839T	8.3
Skin	HS852T	8.4
Skin	HS895T	8.1
Skin	HS934T	8.2
Skin	HS936T	9.1
Skin	HS939T	8.8
Skin	HS940T	8.1
Skin	HS944T	7.7
Skin	HT144	9
Skin	IGR1	9.4
Skin	IGR37	8.3
Skin	IGR39	7.9
Skin	IPC298	9.1
Skin	K029AX	8.6
Skin	LOXIMVI	8.4
Skin	MALME3M	8.3
Skin	MDAMB435S	8.6
Skin	MELHO	9.1
Skin	MELJUSO	8.7
Skin	MEWO	9.3
Skin	RPMI7951	8.6
Skin	RVH421	8.9
Skin	SH4	9.2
Skin	SKMEL1	9.9
Skin	SKMEL24	8
Skin	SKMEL28	8.4
Skin	SKMEL2	8.5
Skin	SKMEL30	9
Skin	SKMEL31	8.2
Skin	SKMEL3	8.7
Skin	SKMEL5	8.6
Skin	UACC257	8.2
Skin	UACC62	9.1
Skin	WM115	8.6
Skin	WM1799	9
Skin	WM2664	8.7
Skin	WM793	8.6
Skin	WM88	8.6
Skin	WM983B	8.5
Small intestine	HUTU80	9.5
Soft tissue	A204	8.5
Soft tissue	G401	9.3
Soft tissue	G402	8.4
Soft tissue	GCT	8.5
Soft tissue	HS729	8.4
Soft tissue	HT1080	8.7
Soft tissue	KYM1	9.6
Soft tissue	MESSA	9.5
Soft tissue	RD	9
Soft tissue	RH30	9.4
Soft tissue	RH41	9.9
Soft tissue	RKN	8.6
Soft tissue	S117	9
Soft tissue	SJRH30	9.3
Soft tissue	SKLMS1	8.9
Soft tissue	SKUT1	9.6
Soft tissue	TE125T	7.9
Soft tissue	TE159T	8
Soft tissue	TE441T	9.7
Soft tissue	TE617T	9.2
Stomach	2313287	7.7
Stomach	AGS	9.2
Stomach	AZ521	9.2
Stomach	ECC10	8.8
Stomach	ECC12	7.9
Stomach	FU97	8.6
Stomach	GCIY	9.2
Stomach	GSS	9.6
Stomach	GSU	10.7
Stomach	HGC27	8.9
Stomach	HS746T	8.6
Stomach	HUG1N	9.1
Stomach	IM95	8.6
Stomach	KATOIII	8.4
Stomach	KE39	9.3
Stomach	LMSU	9.4
Stomach	MKN1	8.8
Stomach	MKN45	9.7
Stomach	MKN74	8.6
Stomach	MKN7	8.8
Stomach	NCCSTCK140	9.1
Stomach	NCIN87	9.1
Stomach	NUGC2	9.1
Stomach	NUGC3	8.2
Stomach	NUGC4	8.2
Stomach	OCUM1	8.6
Stomach	RERFGC1B	9.1
Stomach	SH10TC	8.1
Stomach	SNU16	9.8
Stomach	SNU1	9.4
Stomach	SNU216	9
Stomach	SNU520	8.5
Stomach	SNU5	9.3
Stomach	SNU601	10.1
Stomach	SNU620	9
Stomach	SNU668	8.8
Stomach	SNU719	9.2
Stomach	TGBC11TKB	9.6
Thyroid	8305C	8.7
Thyroid	8505C	9
Thyroid	BCPAP	8.7
Thyroid	BHT101	8.1
Thyroid	CAL62	9.1
Thyroid	CGTHW1	8.7
Thyroid	FTC133	8.1
Thyroid	FTC238	8.8
Thyroid	ML1	8.1
Thyroid	SW579	8.2
Thyroid	TT2609C02	8.6
Thyroid	TT	7.7
Upper aerodigestive tract	BHY	8.3
Upper aerodigestive tract	BICR16	8.4
Upper aerodigestive tract	BICR18	8.8
Upper aerodigestive tract	BICR22	8
Upper aerodigestive tract	BICR31	8.6
Upper aerodigestive tract	BICR56	7.6
Upper aerodigestive tract	BICR6	8.7
Upper aerodigestive tract	CAL27	7.7
Upper aerodigestive tract	CAL33	7.6
Upper aerodigestive tract	DETROIT562	8.5
Upper aerodigestive tract	FADU	9.1
Upper aerodigestive tract	HS840T	8.7
Upper aerodigestive tract	HSC2	8
Upper aerodigestive tract	HSC3	8.8
Upper aerodigestive tract	HSC4	9
Upper aerodigestive tract	PECAPJ15	8.7
Upper aerodigestive tract	PECAPJ34CLONEC12	9.2
Upper aerodigestive tract	PECAPJ41CLONED2	8.5
Upper aerodigestive tract	PECAPJ49	8.7
Upper aerodigestive tract	SCC15	8.1
Upper aerodigestive tract	SCC25	8.5
Upper aerodigestive tract	SCC4	7.8
Upper aerodigestive tract	SCC9	8.5
Upper aerodigestive tract	SNU1076	8.3
Upper aerodigestive tract	SNU1214	8.6
Upper aerodigestive tract	SNU46	8.2
Upper aerodigestive tract	SNU899	8.2
Upper aerodigestive tract	YD10B	8.4
Upper aerodigestive tract	YD38	8.1
Upper aerodigestive tract	YD8	9.6
Urinary tract	5637	9.7
Urinary tract	639V	9.7
Urinary tract	647V	9.6
Urinary tract	BC3C	8.8
Urinary tract	BFTC905	9.5
Urinary tract	CAL29	9.7
Urinary tract	HS172T	8
Urinary tract	HT1197	9.3
Urinary tract	HT1376	9
Urinary tract	J82	8.5
Urinary tract	JMSU1	9.7
Urinary tract	KMBC2	9.1
Urinary tract	KU1919	8.7
Urinary tract	RT11284	9.9
Urinary tract	RT112	9.2
Urinary tract	RT4	9.3
Urinary tract	SCABER	7.7
Urinary tract	SW1710	8.7
Urinary tract	SW780	9.5
Urinary tract	T24	9.5
Urinary tract	TCCSUP	9.6
Urinary tract	UMUC1	8.4
Urinary tract	UMUC3	8.7
Urinary tract	VMCUB1	7.9

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	8.4
Adrenal gland	8.1
Appendix	32.8
Bone marrow	14.4
Breast	9.8
Cerebral cortex	22.6
Cervix, uterine	15
Colon	9.6
Duodenum	11.5
Endometrium	21.2
Epididymis	9
Esophagus	16.2
Fallopian tube	22
Gallbladder	14.2
Heart muscle	5.3
Kidney	6.9
Liver	5.8
Lung	19.3
Lymph node	36.3
Ovary	21.5
Pancreas	1.6
Parathyroid gland	27
Placenta	14
Prostate	10.8
Rectum	11.7
Salivary gland	4.7
Seminal vesicle	11.8
Skeletal muscle	6
Skin	26.1
Small intestine	12.3
Smooth muscle	15.7
Spleen	32.3
Stomach	9.7
Testis	22.2
Thyroid gland	13.8
Tonsil	27.3
Urinary bladder	18.3

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
22086844	Overexpression	Acute Myeloid Leukemia	In AML cell lines and AML-derived ALDH(hi) (high aldehyde dehydrogenase activity)/CD34(+) cells, the levels of JHDM1B mRNA were significantly higher than in normal ALDH(hi) /CD34(+) cells. Compared to normal ALDH(hi) /CD34(+) cells, JHDM1B gene expression was 1.57- to 1.87-fold higher in AML-derived ALDH(hi) /CD34(+) cells.
28706445	Overexpression	Malignant Ovarian Neoplasm	We found that KDM2B expression was gradually increased in ovarian tumors, with the highest expression found in the malignant ovarian tissues, and the differences in KDM2B expression among the different International Federation of Gynecology and Obstetrics stages and pathological grades/types were statistically significant.

Summary
Symbol	KDM2B
Name	lysine demethylase 2B
Aliases	PCCX2; CXXC2; Fbl10; JHDM1B; jumonji C domain-containing histone demethylase 1B; FBXL10; F-box and leucine-r ......
Location	12q24.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.435	4.6e-20	17.1	58.2	24.8	Neutral
BRCA	Breast invasive carcinoma	1075	0.345	2.12e-31	19.7	62.4	17.9	Neutral
CESC	Cervical and endocervical cancers	292	0.428	2.11e-14	7.9	76	16.1	Neutral
COAD	Colon adenocarcinoma	449	0.453	3.97e-24	12.2	67.9	19.8	Neutral
ESCA	Esophageal carcinoma	183	0.537	4.74e-15	24	54.1	21.9	Neutral
GBM	Glioblastoma multiforme	147	0.05	0.546	8.8	82.3	8.8	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.392	2.44e-20	10.9	73.7	15.4	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.169	0.000105	1.1	76	22.9	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.372	6.58e-11	0	60.1	39.9	Gain
LAML	Acute Myeloid Leukemia	166	0.327	1.73e-05	0.6	99.4	0	Neutral
LGG	Brain Lower Grade Glioma	513	0.251	8.27e-09	10.7	85	4.3	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.232	7.4e-06	14	72.8	13.2	Neutral
LUAD	Lung adenocarcinoma	512	0.426	6.17e-24	24	51.8	24.2	Neutral
LUSC	Lung squamous cell carcinoma	498	0.486	6.51e-31	17.5	58.6	23.9	Neutral
OV	Ovarian serous cystadenocarcinoma	300	0.691	5.98e-44	31.3	37.7	31	Neutral
PAAD	Pancreatic adenocarcinoma	177	0.422	4.7e-09	22	68.4	9.6	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.314	4.67e-05	2.5	88.9	8.6	Neutral
PRAD	Prostate adenocarcinoma	491	0.274	6.53e-10	6.3	87.4	6.3	Neutral
READ	Rectum adenocarcinoma	164	0.356	2.87e-06	13.4	72	14.6	Neutral
SARC	Sarcoma	255	0.676	2.23e-35	24.7	55.3	20	Neutral
SKCM	Skin Cutaneous Melanoma	367	0.543	1.45e-29	22.9	67.8	9.3	Neutral
STAD	Stomach adenocarcinoma	413	0.41	3.3e-18	14	63.9	22	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.204	0.0124	1.3	42.7	56	Gain
THCA	Thyroid carcinoma	497	0.374	6.12e-18	0	97	3	Neutral
THYM	Thymoma	119	0.398	7.47e-06	5.9	90.8	3.4	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.417	4.68e-24	12.3	76.9	10.8	Neutral

Summary
Symbol	KDM2B
Name	lysine demethylase 2B
Aliases	PCCX2; CXXC2; Fbl10; JHDM1B; jumonji C domain-containing histone demethylase 1B; FBXL10; F-box and leucine-r ......
Location	12q24.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.163	0.000763	17	408	-0.041	0.393	NS/NA
BRCA	Breast invasive carcinoma	-0.131	0.000117	83	785	-0.028	0.0248	NS/NA
CESC	Cervical and endocervical cancers	-0.193	0.00068	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.131	0.0195	19	297	0.093	5.51e-05	NS/NA
ESCA	Esophageal carcinoma	-0.336	1.98e-06	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.381	0.00185	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.151	0.000419	20	522	0.003	1.6e-09	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.272	3.58e-07	24	319	-0.383	2.35e-19	Decreased
KIRP	Kidney renal papillary cell carcinoma	-0.196	0.000696	23	275	-0.023	0.0517	NS/NA
LAML	Acute Myeloid Leukemia	-0.154	0.0457	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.105	0.0158	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.065	0.187	41	373	0	0.933	NS/NA
LUAD	Lung adenocarcinoma	-0.306	1.15e-11	21	456	0.136	3.67e-09	NS/NA
LUSC	Lung squamous cell carcinoma	-0.208	4.78e-05	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.333	0.385	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.258	0.000449	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.245	0.00076	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.192	8.79e-06	35	498	0.004	0.00216	NS/NA
READ	Rectum adenocarcinoma	-0.191	0.0552	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.21	0.000608	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.233	3.14e-07	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.082	0.116	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.366	3.05e-06	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.154	0.00027	50	509	0.106	1.32e-15	NS/NA
THYM	Thymoma	-0.464	1.07e-07	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.189	4.24e-05	34	431	-0.001	0.754	NS/NA

Summary
Symbol	KDM2B
Name	lysine demethylase 2B
Aliases	PCCX2; CXXC2; Fbl10; JHDM1B; jumonji C domain-containing histone demethylase 1B; FBXL10; F-box and leucine-r ......
Location	12q24.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA) [ TOP ]
There is no antibody staining data.

Summary
Symbol	KDM2B
Name	lysine demethylase 2B
Aliases	PCCX2; CXXC2; Fbl10; JHDM1B; jumonji C domain-containing histone demethylase 1B; FBXL10; F-box and leucine-r ......
Location	12q24.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.805	NS	24476821
BRCA	Breast invasive carcinoma	521	3.68e-25	Significant	23000897
COAD	Colon adenocarcinoma	149	0.137	NS	22810696
GBM	Glioblastoma multiforme	157	7.58e-08	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	1.91e-08	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.0101	Significant	26536169
LGG	Brain Lower Grade Glioma	513	2.42e-16	Significant	26824661
LUAD	Lung adenocarcinoma	230	0.00736	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	0.00089	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.000262	Significant	21720365
PRAD	Prostate adenocarcinoma	333	0.133	NS	26544944
READ	Rectum adenocarcinoma	67	0.988	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.0206	Significant	26091043
STAD	Stomach adenocarcinoma	277	1.05e-07	Significant	25079317
THCA	Thyroid carcinoma	391	1.39e-14	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.278	NS	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	0.811	0.32	NS
BRCA	Breast invasive carcinoma	1079	0.862	0.523	NS
CESC	Cervical and endocervical cancers	291	0.543	0.0487	Longer
COAD	Colon adenocarcinoma	439	1.067	0.814	NS
ESCA	Esophageal carcinoma	184	1.43	0.269	NS
GBM	Glioblastoma multiforme	158	1.043	0.873	NS
HNSC	Head and Neck squamous cell carcinoma	518	0.506	0.000934	Longer
KIRC	Kidney renal clear cell carcinoma	531	2.213	0.000405	Shorter
KIRP	Kidney renal papillary cell carcinoma	287	0.744	0.511	NS
LAML	Acute Myeloid Leukemia	149	0.528	0.0347	Longer
LGG	Brain Lower Grade Glioma	511	0.491	0.00364	Longer
LIHC	Liver hepatocellular carcinoma	365	0.667	0.141	NS
LUAD	Lung adenocarcinoma	502	0.817	0.326	NS
LUSC	Lung squamous cell carcinoma	494	0.732	0.108	NS
OV	Ovarian serous cystadenocarcinoma	303	1.138	0.536	NS
PAAD	Pancreatic adenocarcinoma	177	0.445	0.0139	Longer
PCPG	Pheochromocytoma and Paraganglioma	179	1.122	0.935	NS
PRAD	Prostate adenocarcinoma	497	0.836	0.816	NS
READ	Rectum adenocarcinoma	159	0.407	0.118	NS
SARC	Sarcoma	259	1.875	0.0278	Shorter
SKCM	Skin Cutaneous Melanoma	459	1.71	0.00445	Shorter
STAD	Stomach adenocarcinoma	388	0.848	0.461	NS
TGCT	Testicular Germ Cell Tumors	134	1219008792.827	0.238	NS
THCA	Thyroid carcinoma	500	0.889	0.878	NS
THYM	Thymoma	119	0.678	0.67	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	0.695	0.187	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	-0.064	0.196	NS
BRCA	Breast invasive carcinoma	1071	-0.028	0.354	NS
CESC	Cervical and endocervical cancers	167	0.014	0.857	NS
COAD	Colon adenocarcinoma	445	-0.092	0.0532	NS
ESCA	Esophageal carcinoma	162	-0.011	0.885	NS
HNSC	Head and Neck squamous cell carcinoma	448	-0.049	0.297	NS
KIRC	Kidney renal clear cell carcinoma	531	0.066	0.129	NS
KIRP	Kidney renal papillary cell carcinoma	260	0.006	0.921	NS
LIHC	Liver hepatocellular carcinoma	347	0.013	0.814	NS
LUAD	Lung adenocarcinoma	507	-0.038	0.39	NS
LUSC	Lung squamous cell carcinoma	497	0.028	0.536	NS
OV	Ovarian serous cystadenocarcinoma	302	-0.14	0.0147	Lower
PAAD	Pancreatic adenocarcinoma	176	-0.049	0.515	NS
READ	Rectum adenocarcinoma	156	-0.113	0.16	NS
SKCM	Skin Cutaneous Melanoma	410	-0.062	0.209	NS
STAD	Stomach adenocarcinoma	392	0.007	0.886	NS
TGCT	Testicular Germ Cell Tumors	81	0.221	0.047	Higher
THCA	Thyroid carcinoma	499	-0.031	0.489	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	-0.061	0.171	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	0.061	0.317	NS
HNSC	Head and Neck squamous cell carcinoma	498	0.035	0.439	NS
KIRC	Kidney renal clear cell carcinoma	525	0.084	0.0542	NS
LGG	Brain Lower Grade Glioma	514	0.017	0.701	NS
LIHC	Liver hepatocellular carcinoma	366	0.01	0.846	NS
OV	Ovarian serous cystadenocarcinoma	296	0.135	0.0204	Higher
PAAD	Pancreatic adenocarcinoma	176	0.034	0.65	NS
STAD	Stomach adenocarcinoma	406	0.065	0.194	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	-0.003	0.939	NS

Summary
Symbol	KDM2B
Name	lysine demethylase 2B
Aliases	PCCX2; CXXC2; Fbl10; JHDM1B; jumonji C domain-containing histone demethylase 1B; FBXL10; F-box and leucine-r ......
Location	12q24.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	KDM2B
Name	lysine demethylase 2B
Aliases	PCCX2; CXXC2; Fbl10; JHDM1B; jumonji C domain-containing histone demethylase 1B; FBXL10; F-box and leucine-r ......
Location	12q24.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for KDM2B.

Summary
Symbol	KDM2B
Name	lysine demethylase 2B
Aliases	PCCX2; CXXC2; Fbl10; JHDM1B; jumonji C domain-containing histone demethylase 1B; FBXL10; F-box and leucine-r ......
Location	12q24.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining [ TOP ]
There is no record for KDM2B.