CR2Cancer

Summary
Symbol	KDM3A
Name	lysine demethylase 3A
Aliases	TSGA; KIAA0742; JHMD2A; jumonji C domain-containing histone demethylase 2A; JMJD1; JMJD1A; jumonji domain co ......
Location	2p11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

[ TOP ]

Domain

PF02373 JmjC domain

Function

Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation. Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TMP1 which are required for packaging and condensation of sperm chromatin. Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1.

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification erase	Histone methylation	H3K9me1, H3K9me2	H3K9	16603237

> Gene Ontology [ TOP ]
Biological Process	GO:0006081 cellular aldehyde metabolic process GO:0006479 protein methylation GO:0006482 protein demethylation GO:0006997 nucleus organization GO:0007281 germ cell development GO:0007283 spermatogenesis GO:0007286 spermatid development GO:0007289 spermatid nucleus differentiation GO:0007290 spermatid nucleus elongation GO:0008213 protein alkylation GO:0008214 protein dealkylation GO:0009755 hormone-mediated signaling pathway GO:0016570 histone modification GO:0016571 histone methylation GO:0016577 histone demethylation GO:0018022 peptidyl-lysine methylation GO:0018027 peptidyl-lysine dimethylation GO:0018205 peptidyl-lysine modification GO:0019827 stem cell population maintenance GO:0022412 cellular process involved in reproduction in multicellular organism GO:0030518 intracellular steroid hormone receptor signaling pathway GO:0030521 androgen receptor signaling pathway GO:0030522 intracellular receptor signaling pathway GO:0031056 regulation of histone modification GO:0031057 negative regulation of histone modification GO:0031060 regulation of histone methylation GO:0031061 negative regulation of histone methylation GO:0032259 methylation GO:0033169 histone H3-K9 demethylation GO:0034968 histone lysine methylation GO:0036123 histone H3-K9 dimethylation GO:0043401 steroid hormone mediated signaling pathway GO:0043414 macromolecule methylation GO:0044283 small molecule biosynthetic process GO:0046184 aldehyde biosynthetic process GO:0046292 formaldehyde metabolic process GO:0046293 formaldehyde biosynthetic process GO:0048232 male gamete generation GO:0048515 spermatid differentiation GO:0048545 response to steroid hormone GO:0048863 stem cell differentiation GO:0051567 histone H3-K9 methylation GO:0051570 regulation of histone H3-K9 methylation GO:0051573 negative regulation of histone H3-K9 methylation GO:0061647 histone H3-K9 modification GO:0070076 histone lysine demethylation GO:0070988 demethylation GO:0071383 cellular response to steroid hormone stimulus GO:0071396 cellular response to lipid GO:0071407 cellular response to organic cyclic compound GO:0098727 maintenance of cell number GO:1902275 regulation of chromatin organization GO:1905268 negative regulation of chromatin organization GO:2000036 regulation of stem cell population maintenance GO:2000736 regulation of stem cell differentiation
Molecular Function	GO:0001047 core promoter binding GO:0003682 chromatin binding GO:0005506 iron ion binding GO:0031490 chromatin DNA binding GO:0032451 demethylase activity GO:0032452 histone demethylase activity GO:0032454 histone demethylase activity (H3-K9 specific) GO:0035257 nuclear hormone receptor binding GO:0035258 steroid hormone receptor binding GO:0043566 structure-specific DNA binding GO:0050681 androgen receptor binding GO:0051213 dioxygenase activity GO:0051427 hormone receptor binding
Cellular Component	GO:0000785 chromatin

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-3214842: HDMs demethylate histones

Summary
Symbol	KDM3A
Name	lysine demethylase 3A
Aliases	TSGA; KIAA0742; JHMD2A; jumonji C domain-containing histone demethylase 2A; JMJD1; JMJD1A; jumonji domain co ......
Location	2p11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM3963192	c.3254C>G	p.S1085C	Substitution - Missense	Lung
COSM4096112	c.191G>A	p.C64Y	Substitution - Missense	Stomach
COSM722978	c.2229G>A	p.A743A	Substitution - coding silent	Oesophagus
COSM376187	c.2591C>T	p.T864I	Substitution - Missense	Lung
COSM1023482	c.187G>T	p.V63L	Substitution - Missense	Endometrium
COSM1307068	c.2421C>T	p.A807A	Substitution - coding silent	Urinary_tract
COSM3660001	c.3383A>C	p.N1128T	Substitution - Missense	Liver
COSM4096108	c.69C>T	p.A23A	Substitution - coding silent	Stomach
COSM5603865	c.2225G>A	p.R742K	Substitution - Missense	Skin
COSM5353821	c.284delT	p.L96fs*1	Deletion - Frameshift	Large_intestine
COSM3583821	c.3020T>C	p.V1007A	Substitution - Missense	Skin
COSM1409836	c.1664G>A	p.R555H	Substitution - Missense	Large_intestine
COSM4096136	c.3144G>A	p.W1048*	Substitution - Nonsense	Stomach
COSM1023498	c.1974T>C	p.V658V	Substitution - coding silent	Endometrium
COSM255469	c.2012A>G	p.N671S	Substitution - Missense	Central_nervous_system
COSM1211722	c.1429T>G	p.L477V	Substitution - Missense	Large_intestine
COSM1023512	c.3661C>T	p.R1221C	Substitution - Missense	Endometrium
COSM1023510	c.3205A>T	p.I1069F	Substitution - Missense	Endometrium
COSM4921993	c.2604G>A	p.T868T	Substitution - coding silent	Liver
COSM197613	c.1582G>A	p.E528K	Substitution - Missense	Cervix
COSM4848257	c.2645C>G	p.S882C	Substitution - Missense	Cervix
COSM5914953	c.224G>A	p.R75K	Substitution - Missense	Skin
COSM1307064	c.70G>A	p.D24N	Substitution - Missense	Urinary_tract
COSM4096126	c.1699T>G	p.F567V	Substitution - Missense	Stomach
COSM1615190	c.3490_3491insT	p.E1165fs*1	Insertion - Frameshift	Liver
COSM3799253	c.3670C>G	p.Q1224E	Substitution - Missense	Urinary_tract
COSM1752706	c.3802G>A	p.E1268K	Substitution - Missense	Urinary_tract
COSM4096128	c.2011A>G	p.N671D	Substitution - Missense	Stomach
COSM4583683	c.1630C>T	p.P544S	Substitution - Missense	Bone
COSM359478	c.44G>T	p.R15M	Substitution - Missense	Lung
COSM1615186	c.99G>A	p.W33*	Substitution - Nonsense	Liver
COSM3910738	c.396C>T	p.R132R	Substitution - coding silent	Skin
COSM4096142	c.3508C>G	p.P1170A	Substitution - Missense	Stomach
COSM1307066	c.376G>A	p.G126R	Substitution - Missense	Urinary_tract
COSM5599757	c.1219C>T	p.P407S	Substitution - Missense	Skin
COSM2823059	c.1397A>G	p.N466S	Substitution - Missense	Liver
COSM4792286	c.2093-1G>A	p.?	Unknown	Liver
COSM722980	c.1122G>A	p.Q374Q	Substitution - coding silent	Lung
COSM4618262	c.3842G>A	p.R1281Q	Substitution - Missense	Large_intestine
COSM1023490	c.561C>A	p.D187E	Substitution - Missense	Upper_aerodigestive_tract
COSM4694926	c.1122G>T	p.Q374H	Substitution - Missense	Large_intestine
COSM329003	c.1663C>T	p.R555C	Substitution - Missense	Liver
COSM5511739	c.1301C>T	p.P434L	Substitution - Missense	Biliary_tract
COSM722978	c.2229G>A	p.A743A	Substitution - coding silent	Lung
COSM722982	c.713T>A	p.L238Q	Substitution - Missense	Lung
COSM1023490	c.561C>A	p.D187E	Substitution - Missense	Upper_aerodigestive_tract
COSM1197567	c.1595A>T	p.Q532L	Substitution - Missense	Lung
COSM1023490	c.561C>A	p.D187E	Substitution - Missense	Endometrium
COSM3426737	c.2154G>A	p.E718E	Substitution - coding silent	Large_intestine
COSM5723576	c.436C>T	p.L146F	Substitution - Missense	Skin
COSM1669122	c.2491A>C	p.N831H	Substitution - Missense	Large_intestine
COSM4488611	c.3355C>G	p.L1119V	Substitution - Missense	Skin
COSM5482616	c.3216C>T	p.P1072P	Substitution - coding silent	Large_intestine
COSM4944009	c.273A>G	p.E91E	Substitution - coding silent	Liver
COSM5984118	c.79G>A	p.D27N	Substitution - Missense	Upper_aerodigestive_tract
COSM477721	c.3915A>G	p.K1305K	Substitution - coding silent	Kidney
COSM2823127	c.3200C>A	p.A1067D	Substitution - Missense	Large_intestine
COSM4792286	c.2093-1G>A	p.?	Unknown	Liver
COSM1023506	c.2948A>C	p.H983P	Substitution - Missense	Endometrium
COSM5035001	c.2985C>T	p.F995F	Substitution - coding silent	Oesophagus
COSM1023490	c.561C>A	p.D187E	Substitution - Missense	Upper_aerodigestive_tract
COSM5638689	c.1107C>G	p.L369L	Substitution - coding silent	Oesophagus
COSM4096118	c.735C>T	p.H245H	Substitution - coding silent	Stomach
COSM5779964	c.1168T>A	p.C390S	Substitution - Missense	Breast
COSM1615188	c.3203A>C	p.N1068T	Substitution - Missense	Liver
COSM1752704	c.469C>T	p.R157*	Substitution - Nonsense	Urinary_tract
COSM3714315	c.30G>C	p.P10P	Substitution - coding silent	Upper_aerodigestive_tract
COSM4694936	c.3546G>A	p.T1182T	Substitution - coding silent	Large_intestine
COSM240323	c.2422G>C	p.G808R	Substitution - Missense	Prostate
COSM1409846	c.3097C>T	p.R1033C	Substitution - Missense	Large_intestine
COSM3583823	c.3076G>T	p.G1026*	Substitution - Nonsense	Skin
COSM1023502	c.2656C>A	p.R886R	Substitution - coding silent	Endometrium
COSM3963190	c.1263G>C	p.K421N	Substitution - Missense	Lung
COSM1483332	c.3685C>G	p.Q1229E	Substitution - Missense	Breast
COSM1023490	c.561C>A	p.D187E	Substitution - Missense	Upper_aerodigestive_tract
COSM1483330	c.2647G>A	p.G883S	Substitution - Missense	Breast
COSM1023490	c.561C>A	p.D187E	Substitution - Missense	Upper_aerodigestive_tract
COSM240325	c.3267C>G	p.N1089K	Substitution - Missense	Prostate
COSM3739964	c.431A>T	p.K144I	Substitution - Missense	Liver
COSM81329	c.2628C>G	p.P876P	Substitution - coding silent	Ovary
COSM1409848	c.3747T>C	p.H1249H	Substitution - coding silent	Large_intestine
COSM166088	c.1351_1358delAATGCACC	p.N451fs*8	Deletion - Frameshift	Breast
COSM4999475	c.1039T>C	p.S347P	Substitution - Missense	Pancreas
COSM148891	c.1559T>A	p.L520H	Substitution - Missense	Stomach
COSM1023496	c.1438C>T	p.R480*	Substitution - Nonsense	Large_intestine
COSM722972	c.3933G>A	p.L1311L	Substitution - coding silent	Lung
COSM1409850	c.3896T>C	p.V1299A	Substitution - Missense	Large_intestine
COSM4141285	c.1976G>A	p.R659Q	Substitution - Missense	Ovary
COSM477715	c.2876A>G	p.N959S	Substitution - Missense	Kidney
COSM4096116	c.319C>T	p.R107*	Substitution - Nonsense	Stomach
COSM5436698	c.2458C>A	p.P820T	Substitution - Missense	Oesophagus
COSM1729231	c.2242A>T	p.K748*	Substitution - Nonsense	Liver
COSM4096124	c.1590C>T	p.F530F	Substitution - coding silent	Stomach
COSM5938889	c.2762C>T	p.S921F	Substitution - Missense	Skin
COSM2823023	c.395G>A	p.R132H	Substitution - Missense	Large_intestine
COSM5897373	c.2923-1G>C	p.?	Unknown	Skin
COSM4608897	c.3434-1G>T	p.?	Unknown	Adrenal_gland
COSM1752704	c.469C>T	p.R157*	Substitution - Nonsense	Urinary_tract
COSM3840179	c.1073G>T	p.R358I	Substitution - Missense	Breast
COSM4694936	c.3546G>A	p.T1182T	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM1023486	c.366A>C	p.K122N	Substitution - Missense	Endometrium
COSM1136737	c.1468A>C	p.K490Q	Substitution - Missense	Kidney
COSM392501	c.329delA	p.Q110fs*5	Deletion - Frameshift	Lung
COSM5779623	c.53T>A	p.L18H	Substitution - Missense	Breast
COSM3972382	c.1706G>A	p.R569H	Substitution - Missense	Central_nervous_system
COSM4096140	c.3376G>A	p.A1126T	Substitution - Missense	Stomach
COSM1743615	c.3314-2A>T	p.?	Unknown	Biliary_tract
COSM4694928	c.1257T>C	p.P419P	Substitution - coding silent	Large_intestine
COSM1615188	c.3203A>C	p.N1068T	Substitution - Missense	Liver
COSM1023504	c.2778G>A	p.R926R	Substitution - coding silent	Endometrium
COSM2823036	c.573T>A	p.V191V	Substitution - coding silent	Large_intestine
COSM5723576	c.436C>T	p.L146F	Substitution - Missense	Skin
COSM4758450	c.397T>G	p.F133V	Substitution - Missense	Stomach
COSM4446290	c.3095-3C>G	p.?	Unknown	Skin
COSM4449793	c.3314-1G>A	p.?	Unknown	Skin
COSM4484659	c.2836C>G	p.L946V	Substitution - Missense	Skin
COSM4436850	c.3095-3C>T	p.?	Unknown	Oesophagus
COSM1669120	c.2188G>T	p.A730S	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5615137	c.2425A>T	p.S809C	Substitution - Missense	Lung
COSM443328	c.2279T>G	p.L760R	Substitution - Missense	Breast
COSM1023488	c.505G>T	p.E169*	Substitution - Nonsense	Endometrium
COSM722972	c.3933G>A	p.L1311L	Substitution - coding silent	Oesophagus
COSM4096138	c.3309T>G	p.A1103A	Substitution - coding silent	Stomach
COSM3840185	c.2898T>C	p.F966F	Substitution - coding silent	Breast
COSM1023490	c.561C>A	p.D187E	Substitution - Missense	Upper_aerodigestive_tract
COSM359476	c.16G>T	p.G6*	Substitution - Nonsense	Lung
COSM3391883	c.2777G>A	p.R926K	Substitution - Missense	Pancreas
COSM1255488	c.2288A>G	p.K763R	Substitution - Missense	Oesophagus
COSM1725312	c.2426G>A	p.S809N	Substitution - Missense	Liver
COSM4478159	c.2215C>T	p.H739Y	Substitution - Missense	Skin
COSM1023490	c.561C>A	p.D187E	Substitution - Missense	Upper_aerodigestive_tract
COSM5599757	c.1219C>T	p.P407S	Substitution - Missense	Skin
COSM5802226	c.1008-5_1040del38	p.?	Unknown	Breast
COSM1197567	c.1595A>T	p.Q532L	Substitution - Missense	Lung
COSM3840181	c.1434T>C	p.A478A	Substitution - coding silent	Breast
COSM5811321	c.3314G>T	p.G1105V	Substitution - Missense	Liver
COSM1211720	c.52C>A	p.L18I	Substitution - Missense	Large_intestine
COSM4096132	c.2290C>T	p.P764S	Substitution - Missense	Stomach
COSM4979360	c.3124G>A	p.V1042M	Substitution - Missense	Oesophagus
COSM5599757	c.1219C>T	p.P407S	Substitution - Missense	Skin
COSM1632152	c.1439G>T	p.R480L	Substitution - Missense	Liver
COSM5973915	c.430A>G	p.K144E	Substitution - Missense	Upper_aerodigestive_tract
COSM1136737	c.1468A>C	p.K490Q	Substitution - Missense	Large_intestine
COSM3840183	c.2007C>G	p.I669M	Substitution - Missense	Breast
COSM5736117	c.3171G>T	p.M1057I	Substitution - Missense	Small_intestine
COSM1023488	c.505G>T	p.E169*	Substitution - Nonsense	Endometrium
COSM1757060	c.1205G>A	p.R402K	Substitution - Missense	Urinary_tract
COSM477717	c.3307G>A	p.A1103T	Substitution - Missense	Kidney
COSM1023492	c.727G>T	p.V243F	Substitution - Missense	Endometrium
COSM1307064	c.70G>A	p.D24N	Substitution - Missense	Cervix
COSM2823093	c.2145T>C	p.H715H	Substitution - coding silent	Large_intestine
COSM3739962	c.420A>G	p.V140V	Substitution - coding silent	Liver
COSM3583825	c.3305A>C	p.N1102T	Substitution - Missense	Skin
COSM4777561	c.1638C>A	p.C546*	Substitution - Nonsense	Prostate
COSM108842	c.1000C>T	p.P334S	Substitution - Missense	Skin
COSM148892	c.1560C>T	p.L520L	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM3408020	c.1857G>A	p.K619K	Substitution - coding silent	Central_nervous_system
COSM5440940	c.3095-1G>T	p.?	Unknown	Oesophagus
COSM123885	c.3371C>G	p.S1124C	Substitution - Missense	Upper_aerodigestive_tract
COSM4758454	c.2447C>T	p.A816V	Substitution - Missense	Stomach
COSM5973917	c.1264G>T	p.A422S	Substitution - Missense	Upper_aerodigestive_tract
COSM1023490	c.561C>A	p.D187E	Substitution - Missense	Upper_aerodigestive_tract
COSM30412	c.559G>C	p.D187H	Substitution - Missense	Breast
COSM1752706	c.3802G>A	p.E1268K	Substitution - Missense	Urinary_tract
COSM3840187	c.3108T>C	p.N1036N	Substitution - coding silent	Breast
COSM1409836	c.1664G>A	p.R555H	Substitution - Missense	Large_intestine
COSM347461	c.2219C>A	p.S740Y	Substitution - Missense	Lung
COSM3718572	c.2656C>T	p.R886W	Substitution - Missense	Upper_aerodigestive_tract
COSM4694924	c.708G>A	p.P236P	Substitution - coding silent	Large_intestine
COSM3660001	c.3383A>C	p.N1128T	Substitution - Missense	Liver
COSM1023490	c.561C>A	p.D187E	Substitution - Missense	Upper_aerodigestive_tract
COSM2823036	c.573T>A	p.V191V	Substitution - coding silent	Large_intestine
COSM2823049	c.974C>T	p.S325F	Substitution - Missense	Liver
COSM5553209	c.841G>C	p.E281Q	Substitution - Missense	Prostate
COSM4479865	c.2368C>T	p.P790S	Substitution - Missense	Skin
COSM255469	c.2012A>G	p.N671S	Substitution - Missense	Central_nervous_system
COSM2823015	c.200T>A	p.F67Y	Substitution - Missense	Large_intestine
COSM722974	c.3001G>T	p.E1001*	Substitution - Nonsense	Lung
COSM4758448	c.326T>C	p.V109A	Substitution - Missense	Stomach
COSM5653227	c.669C>T	p.V223V	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM3372891	c.2239A>G	p.I747V	Substitution - Missense	Thyroid
COSM1023496	c.1438C>T	p.R480*	Substitution - Nonsense	Endometrium
COSM3583819	c.2738C>T	p.S913F	Substitution - Missense	Skin
COSM5353821	c.284delT	p.L96fs*1	Deletion - Frameshift	Large_intestine
COSM1757060	c.1205G>A	p.R402K	Substitution - Missense	Urinary_tract
COSM5883507	c.3040A>T	p.I1014F	Substitution - Missense	Skin
COSM4569450	c.1765T>C	p.F589L	Substitution - Missense	Skin
COSM4421667	c.2759C>G	p.T920S	Substitution - Missense	Pleura
COSM1023496	c.1438C>T	p.R480*	Substitution - Nonsense	Large_intestine
COSM148891	c.1559T>A	p.L520H	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1669122	c.2491A>C	p.N831H	Substitution - Missense	Large_intestine
COSM4694932	c.1739A>C	p.K580T	Substitution - Missense	Large_intestine
COSM3380240	c.3017T>C	p.L1006P	Substitution - Missense	Pancreas
COSM5635623	c.2762C>A	p.S921Y	Substitution - Missense	Oesophagus
COSM1409844	c.2848C>T	p.R950C	Substitution - Missense	Large_intestine
COSM1615186	c.99G>A	p.W33*	Substitution - Nonsense	Liver
COSM5892733	c.601G>A	p.D201N	Substitution - Missense	Skin
COSM1729758	c.3215C>G	p.P1072R	Substitution - Missense	Liver
COSM4758456	c.3670C>T	p.Q1224*	Substitution - Nonsense	Stomach
COSM3583817	c.1433C>T	p.A478V	Substitution - Missense	Skin
COSM3380242	c.3612C>T	p.H1204H	Substitution - coding silent	Pancreas
COSM3426739	c.3037G>A	p.E1013K	Substitution - Missense	Large_intestine
COSM1023484	c.224G>T	p.R75I	Substitution - Missense	Endometrium
COSM4483094	c.2672C>G	p.S891C	Substitution - Missense	Skin
COSM3426741	c.3563T>G	p.F1188C	Substitution - Missense	Large_intestine
COSM148893	c.3561A>G	p.E1187E	Substitution - coding silent	Stomach
COSM1023496	c.1438C>T	p.R480*	Substitution - Nonsense	Central_nervous_system
COSM443330	c.2486G>A	p.S829N	Substitution - Missense	Breast
COSM1176892	c.277A>C	p.N93H	Substitution - Missense	Endometrium
COSM1130729	c.2143C>T	p.H715Y	Substitution - Missense	Prostate
COSM4694938	c.3568delA	p.K1191fs*24	Deletion - Frameshift	Large_intestine
COSM3758401	c.1339T>C	p.S447P	Substitution - Missense	Large_intestine
COSM30412	c.559G>C	p.D187H	Substitution - Missense	Breast
COSM2823059	c.1397A>G	p.N466S	Substitution - Missense	Liver
COSM1409830	c.672C>T	p.N224N	Substitution - coding silent	Large_intestine
COSM5619718	c.629C>G	p.T210S	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1023490	c.561C>A	p.D187E	Substitution - Missense	Upper_aerodigestive_tract
COSM3718572	c.2656C>T	p.R886W	Substitution - Missense	Upper_aerodigestive_tract
COSM4096110	c.114C>T	p.V38V	Substitution - coding silent	Stomach
COSM3739966	c.3500A>C	p.K1167T	Substitution - Missense	Liver
COSM3714315	c.30G>C	p.P10P	Substitution - coding silent	Upper_aerodigestive_tract
COSM1752704	c.469C>T	p.R157*	Substitution - Nonsense	Urinary_tract
COSM4694934	c.1995C>T	p.C665C	Substitution - coding silent	Large_intestine
COSM1023508	c.2951A>C	p.K984T	Substitution - Missense	Endometrium
COSM3963186	c.1006G>C	p.G336R	Substitution - Missense	Lung
COSM272842	c.993delA	p.I333fs*18	Deletion - Frameshift	Large_intestine
COSM4096134	c.2803A>G	p.S935G	Substitution - Missense	Stomach
COSM148892	c.1560C>T	p.L520L	Substitution - coding silent	Stomach
COSM5805568	c.40G>T	p.G14W	Substitution - Missense	Liver
COSM3963188	c.1188C>T	p.N396N	Substitution - coding silent	Lung
COSM1023500	c.2533A>C	p.I845L	Substitution - Missense	Endometrium
COSM5599757	c.1219C>T	p.P407S	Substitution - Missense	Skin
COSM6006762	c.1936C>T	p.H646Y	Substitution - Missense	Prostate
COSM40207	c.1400G>A	p.C467Y	Substitution - Missense	Central_nervous_system
COSM4637900	c.3919G>A	p.A1307T	Substitution - Missense	Large_intestine
COSM5723576	c.436C>T	p.L146F	Substitution - Missense	Skin
COSM4096114	c.293A>G	p.E98G	Substitution - Missense	Stomach
COSM5612019	c.3259C>A	p.L1087M	Substitution - Missense	Adrenal_gland
COSM5599757	c.1219C>T	p.P407S	Substitution - Missense	Skin
COSM5823386	c.3069C>G	p.F1023L	Substitution - Missense	Liver
COSM5430093	c.320G>A	p.R107Q	Substitution - Missense	Oesophagus
COSM4096122	c.1333T>C	p.S445P	Substitution - Missense	Stomach
COSM2823099	c.2221G>C	p.V741L	Substitution - Missense	Upper_aerodigestive_tract
COSM1023494	c.956C>T	p.T319I	Substitution - Missense	Endometrium
COSM4096130	c.2061C>T	p.C687C	Substitution - coding silent	Stomach
COSM4694930	c.1649G>A	p.R550H	Substitution - Missense	Large_intestine
COSM1023490	c.561C>A	p.D187E	Substitution - Missense	Upper_aerodigestive_tract
COSM4432637	c.1778A>G	p.N593S	Substitution - Missense	Oesophagus
COSM477719	c.3639T>C	p.Y1213Y	Substitution - coding silent	Kidney
COSM5474513	c.1622C>G	p.A541G	Substitution - Missense	Large_intestine
COSM4096120	c.1226C>T	p.A409V	Substitution - Missense	Stomach
COSM5892733	c.601G>A	p.D201N	Substitution - Missense	Skin
COSM5723576	c.436C>T	p.L146F	Substitution - Missense	Skin
COSM3426735	c.309A>C	p.E103D	Substitution - Missense	Large_intestine
COSM126760	c.3851C>A	p.S1284*	Substitution - Nonsense	Upper_aerodigestive_tract
COSM1752704	c.469C>T	p.R157*	Substitution - Nonsense	Urinary_tract
COSM1211724	c.2703G>T	p.K901N	Substitution - Missense	Large_intestine
COSM4648623	c.1416A>G	p.V472V	Substitution - coding silent	Large_intestine
COSM3583815	c.1334C>T	p.S445F	Substitution - Missense	Skin

> Text Mining based Variations

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PMID	Variation	Cancer	Evidence
25189356	Mutation	Prostate carsinoma	From this genome-wide approach, mutations were found in a series of genes with prostate cancer relevance, including AR, NCOR1, KDM3A, KDM4A, CHD1, SETD5, SETD7, INPP4B, RASGRP3, RASA1, TP53BP1, and CDH1, and a novel SND1:BRAF gene fusion.

Summary
Symbol	KDM3A
Name	lysine demethylase 3A
Aliases	TSGA; KIAA0742; JHMD2A; jumonji C domain-containing histone demethylase 2A; JMJD1; JMJD1A; jumonji domain co ......
Location	2p11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

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Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
Q9Y4C1	325	S	Phosphoserine	-	No	None detected
Q9Y4C1	445	S	Phosphoserine	-	Yes	p.S445F (cancer: SKCM); p.S445P (cancer: STAD)
Q9Y4C1	766	S	Phosphoserine	-	No	None detected
Q9Y4C1	895	K	N6-acetyllysine	-	No	None detected

Summary
Symbol	KDM3A
Name	lysine demethylase 3A
Aliases	TSGA; KIAA0742; JHMD2A; jumonji C domain-containing histone demethylase 2A; JMJD1; JMJD1A; jumonji domain co ......
Location	2p11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

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Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	5.841	5.785	0.104	0.585	NS
BRCA	Breast invasive carcinoma	112	1100	6.209	6.178	0.006	0.911	NS
CESC	Cervical and endocervical cancers	3	306	6.046	6.368	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	5.685	5.944	0.302	0.00101	NS
ESCA	Esophageal carcinoma	11	185	5.705	6.093	0.325	0.115	NS
GBM	Glioblastoma multiforme	5	166	5.73	6.312	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	5.687	5.942	0.211	0.0687	NS
KIRC	Kidney renal clear cell carcinoma	72	534	5.617	6.417	0.768	4.32e-35	Over
KIRP	Kidney renal papillary cell carcinoma	32	291	5.336	5.957	0.519	1.85e-07	NS
LAML	Acute Myeloid Leukemia	0	173	NA	6.684	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	6.565	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	4.329	4.555	0.26	0.00805	NS
LUAD	Lung adenocarcinoma	59	517	5.796	5.958	0.272	2.25e-05	NS
LUSC	Lung squamous cell carcinoma	51	501	5.718	6.576	0.92	1.15e-20	Over
OV	Ovarian serous cystadenocarcinoma	0	307	NA	6.169	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	5.894	5.913	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	5.183	5.628	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	5.717	5.664	-0.103	0.138	NS
READ	Rectum adenocarcinoma	10	167	5.752	5.926	0.134	0.603	NS
SARC	Sarcoma	2	263	5.118	5.497	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	5.893	6.172	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	5.433	5.679	0.157	0.197	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	6.295	NA	NA	NA
THCA	Thyroid carcinoma	59	509	6.063	5.913	-0.133	0.0113	NS
THYM	Thymoma	2	120	6.2	5.915	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	5.849	6.02	0.118	0.303	NS

> Cancer Cell Line Encyclopedia (CCLE)

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Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	10.9
Autonomic ganglia	CHP212	9.7
Autonomic ganglia	IMR32	10.8
Autonomic ganglia	KELLY	9.2
Autonomic ganglia	KPNRTBM1	10.5
Autonomic ganglia	KPNSI9S	9.6
Autonomic ganglia	KPNYN	10.3
Autonomic ganglia	MHHNB11	10.5
Autonomic ganglia	NB1	9.5
Autonomic ganglia	NH6	10.1
Autonomic ganglia	SHSY5Y	10.3
Autonomic ganglia	SIMA	10
Autonomic ganglia	SKNAS	9.6
Autonomic ganglia	SKNBE2	10
Autonomic ganglia	SKNDZ	10.1
Autonomic ganglia	SKNFI	9.2
Autonomic ganglia	SKNSH	9.5
Biliary tract	HUCCT1	9.4
Biliary tract	HUH28	9
Biliary tract	SNU1079	10
Biliary tract	SNU1196	9.1
Biliary tract	SNU245	8.9
Biliary tract	SNU308	9.2
Biliary tract	SNU478	8.9
Bone	143B	8.7
Bone	A673	9.4
Bone	CADOES1	10
Bone	CAL78	10.4
Bone	G292CLONEA141B1	10.7
Bone	HOS	8.5
Bone	HS706T	8.8
Bone	HS737T	8.9
Bone	HS819T	9.1
Bone	HS821T	9.1
Bone	HS822T	9.7
Bone	HS863T	8.8
Bone	HS870T	8.5
Bone	HS888T	8.6
Bone	MG63	8.8
Bone	MHHES1	10.4
Bone	OUMS27	9.3
Bone	RDES	9.7
Bone	SJSA1	9.3
Bone	SKES1	9.8
Bone	SKNMC	9.8
Bone	SW1353	10.2
Bone	T173	8.3
Bone	TC71	9.6
Bone	U2OS	8.9
Breast	AU565	9
Breast	BT20	8.7
Breast	BT474	10
Breast	BT483	9.5
Breast	BT549	9.1
Breast	CAL120	8.9
Breast	CAL148	9.9
Breast	CAL51	9.6
Breast	CAL851	9.4
Breast	CAMA1	9
Breast	DU4475	8.8
Breast	EFM192A	8.8
Breast	EFM19	9.1
Breast	EVSAT	8.4
Breast	HCC1143	9.9
Breast	HCC1187	9
Breast	HCC1395	10.5
Breast	HCC1419	9.8
Breast	HCC1428	9.9
Breast	HCC1500	8.8
Breast	HCC1569	10.6
Breast	HCC1599	9.8
Breast	HCC1806	8.4
Breast	HCC1937	9
Breast	HCC1954	9.4
Breast	HCC202	9.6
Breast	HCC2157	9.9
Breast	HCC2218	8.7
Breast	HCC38	9.4
Breast	HCC70	9.1
Breast	HDQP1	9.8
Breast	HMC18	9.8
Breast	HS274T	8.6
Breast	HS281T	8.3
Breast	HS343T	8.2
Breast	HS578T	9.8
Breast	HS606T	9.5
Breast	HS739T	9.3
Breast	HS742T	9.4
Breast	JIMT1	9
Breast	KPL1	9.4
Breast	MCF7	9
Breast	MDAMB134VI	10
Breast	MDAMB157	10.5
Breast	MDAMB175VII	8.4
Breast	MDAMB231	9.4
Breast	MDAMB361	9.5
Breast	MDAMB415	8.5
Breast	MDAMB436	9.6
Breast	MDAMB453	9.4
Breast	MDAMB468	9.2
Breast	SKBR3	9.1
Breast	T47D	8.5
Breast	UACC812	9.5
Breast	UACC893	8.6
Breast	YMB1	8.8
Breast	ZR751	9.2
Breast	ZR7530	8.7
Central nervous system	1321N1	9.8
Central nervous system	42MGBA	9.2
Central nervous system	8MGBA	9.1
Central nervous system	A172	8.9
Central nervous system	AM38	9.3
Central nervous system	BECKER	10.4
Central nervous system	CAS1	9.5
Central nervous system	CCFSTTG1	8.3
Central nervous system	D283MED	10.2
Central nervous system	D341MED	10.1
Central nervous system	DAOY	8.5
Central nervous system	DBTRG05MG	9.5
Central nervous system	DKMG	7.9
Central nervous system	GAMG	9.3
Central nervous system	GB1	10
Central nervous system	GI1	8.1
Central nervous system	GMS10	8.3
Central nervous system	GOS3	9.8
Central nervous system	H4	9.1
Central nervous system	HS683	8.7
Central nervous system	KALS1	10.6
Central nervous system	KG1C	9.8
Central nervous system	KNS42	9.9
Central nervous system	KNS60	9.5
Central nervous system	KNS81	9.2
Central nervous system	KS1	9
Central nervous system	LN18	9.4
Central nervous system	LN229	9.6
Central nervous system	M059K	8.7
Central nervous system	MOGGCCM	9.4
Central nervous system	MOGGUVW	9.1
Central nervous system	NMCG1	8.5
Central nervous system	ONS76	10.2
Central nervous system	SF126	9.3
Central nervous system	SF295	8.6
Central nervous system	SNB19	8.9
Central nervous system	SNU1105	10
Central nervous system	SNU201	9.8
Central nervous system	SNU466	10.1
Central nervous system	SNU489	9.6
Central nervous system	SNU626	8.4
Central nervous system	SNU738	9.7
Central nervous system	SW1088	9.8
Central nervous system	SW1783	9.2
Central nervous system	T98G	9.6
Central nervous system	TM31	10.3
Central nervous system	U118MG	8.7
Central nervous system	U138MG	9.7
Central nervous system	U251MG	10.2
Central nervous system	U87MG	10.1
Central nervous system	YH13	8.8
Central nervous system	YKG1	9.2
Endometrium	AN3CA	8
Endometrium	COLO684	10.7
Endometrium	EFE184	9.6
Endometrium	EN	9.1
Endometrium	ESS1	9.1
Endometrium	HEC108	10.5
Endometrium	HEC151	8.4
Endometrium	HEC1A	9.3
Endometrium	HEC1B	9.8
Endometrium	HEC251	9.6
Endometrium	HEC265	6.9
Endometrium	HEC50B	9.3
Endometrium	HEC59	9.6
Endometrium	HEC6	9.1
Endometrium	ISHIKAWAHERAKLIO02ER	8.7
Endometrium	JHUEM1	9.8
Endometrium	JHUEM2	10.5
Endometrium	JHUEM3	9.8
Endometrium	KLE	8.7
Endometrium	MFE280	9.2
Endometrium	MFE296	9.4
Endometrium	MFE319	9.3
Endometrium	RL952	9.6
Endometrium	SNGM	8.7
Endometrium	SNU1077	9.7
Endometrium	SNU685	9.8
Endometrium	TEN	9
Haematopoietic and lymphoid	697	9.7
Haematopoietic and lymphoid	A3KAW	9.2
Haematopoietic and lymphoid	A4FUK	9.2
Haematopoietic and lymphoid	ALLSIL	10.4
Haematopoietic and lymphoid	AML193	9.5
Haematopoietic and lymphoid	AMO1	10.2
Haematopoietic and lymphoid	BCP1	9.9
Haematopoietic and lymphoid	BDCM	9.3
Haematopoietic and lymphoid	BL41	9.2
Haematopoietic and lymphoid	BL70	9.4
Haematopoietic and lymphoid	BV173	9.6
Haematopoietic and lymphoid	CA46	10
Haematopoietic and lymphoid	CI1	9.2
Haematopoietic and lymphoid	CMK115	10
Haematopoietic and lymphoid	CMK86	10.4
Haematopoietic and lymphoid	CMK	10.3
Haematopoietic and lymphoid	CMLT1	10.7
Haematopoietic and lymphoid	COLO775	9.8
Haematopoietic and lymphoid	DAUDI	9.8
Haematopoietic and lymphoid	DB	9.7
Haematopoietic and lymphoid	DEL	9.6
Haematopoietic and lymphoid	DND41	11.3
Haematopoietic and lymphoid	DOHH2	9.4
Haematopoietic and lymphoid	EB1	9.6
Haematopoietic and lymphoid	EB2	10.3
Haematopoietic and lymphoid	EHEB	9
Haematopoietic and lymphoid	EJM	10.2
Haematopoietic and lymphoid	EM2	9.1
Haematopoietic and lymphoid	EOL1	10
Haematopoietic and lymphoid	F36P	9.6
Haematopoietic and lymphoid	GA10	9.4
Haematopoietic and lymphoid	GDM1	10.2
Haematopoietic and lymphoid	GRANTA519	9.5
Haematopoietic and lymphoid	HDLM2	9.3
Haematopoietic and lymphoid	HDMYZ	9.6
Haematopoietic and lymphoid	HEL9217	9.8
Haematopoietic and lymphoid	HEL	9.5
Haematopoietic and lymphoid	HH	9.2
Haematopoietic and lymphoid	HL60	10
Haematopoietic and lymphoid	HPBALL	11.7
Haematopoietic and lymphoid	HS604T	8.7
Haematopoietic and lymphoid	HS611T	8.5
Haematopoietic and lymphoid	HS616T	9.1
Haematopoietic and lymphoid	HS751T	8.5
Haematopoietic and lymphoid	HT	9.9
Haematopoietic and lymphoid	HTK	8.5
Haematopoietic and lymphoid	HUNS1	9.2
Haematopoietic and lymphoid	HUT102	9.6
Haematopoietic and lymphoid	HUT78	9.1
Haematopoietic and lymphoid	JEKO1	10.8
Haematopoietic and lymphoid	JK1	10.3
Haematopoietic and lymphoid	JM1	10.4
Haematopoietic and lymphoid	JURKAT	9.2
Haematopoietic and lymphoid	JURLMK1	9.6
Haematopoietic and lymphoid	JVM2	9.8
Haematopoietic and lymphoid	JVM3	9.4
Haematopoietic and lymphoid	K562	10.1
Haematopoietic and lymphoid	KARPAS299	10.1
Haematopoietic and lymphoid	KARPAS422	10.6
Haematopoietic and lymphoid	KARPAS620	9.9
Haematopoietic and lymphoid	KASUMI1	10.2
Haematopoietic and lymphoid	KASUMI2	9.9
Haematopoietic and lymphoid	KASUMI6	10.2
Haematopoietic and lymphoid	KCL22	9.2
Haematopoietic and lymphoid	KE37	9.9
Haematopoietic and lymphoid	KE97	9.5
Haematopoietic and lymphoid	KG1	10.2
Haematopoietic and lymphoid	KHM1B	9.7
Haematopoietic and lymphoid	KIJK	10.6
Haematopoietic and lymphoid	KMH2	9.5
Haematopoietic and lymphoid	KMM1	9.3
Haematopoietic and lymphoid	KMS11	10.3
Haematopoietic and lymphoid	KMS12BM	9.8
Haematopoietic and lymphoid	KMS18	9.5
Haematopoietic and lymphoid	KMS20	10.4
Haematopoietic and lymphoid	KMS21BM	9.5
Haematopoietic and lymphoid	KMS26	10.4
Haematopoietic and lymphoid	KMS27	9.6
Haematopoietic and lymphoid	KMS28BM	10.2
Haematopoietic and lymphoid	KMS34	9.8
Haematopoietic and lymphoid	KO52	9.8
Haematopoietic and lymphoid	KOPN8	9.2
Haematopoietic and lymphoid	KU812	9.7
Haematopoietic and lymphoid	KYO1	10.8
Haematopoietic and lymphoid	L1236	9
Haematopoietic and lymphoid	L363	10
Haematopoietic and lymphoid	L428	8.7
Haematopoietic and lymphoid	L540	10.2
Haematopoietic and lymphoid	LAMA84	9.4
Haematopoietic and lymphoid	LOUCY	10.7
Haematopoietic and lymphoid	LP1	10.8
Haematopoietic and lymphoid	M07E	10
Haematopoietic and lymphoid	MC116	9.1
Haematopoietic and lymphoid	ME1	9.6
Haematopoietic and lymphoid	MEC1	9.2
Haematopoietic and lymphoid	MEC2	9.1
Haematopoietic and lymphoid	MEG01	9.4
Haematopoietic and lymphoid	MHHCALL2	9.7
Haematopoietic and lymphoid	MHHCALL3	10.2
Haematopoietic and lymphoid	MHHCALL4	10.2
Haematopoietic and lymphoid	MINO	9.4
Haematopoietic and lymphoid	MJ	8.9
Haematopoietic and lymphoid	MM1S	9.9
Haematopoietic and lymphoid	MOLM13	9.7
Haematopoietic and lymphoid	MOLM16	10
Haematopoietic and lymphoid	MOLM6	10.9
Haematopoietic and lymphoid	MOLP2	10.8
Haematopoietic and lymphoid	MOLP8	9.6
Haematopoietic and lymphoid	MOLT13	10.4
Haematopoietic and lymphoid	MOLT16	9.9
Haematopoietic and lymphoid	MOLT4	9.7
Haematopoietic and lymphoid	MONOMAC1	10.6
Haematopoietic and lymphoid	MONOMAC6	9.7
Haematopoietic and lymphoid	MOTN1	10.2
Haematopoietic and lymphoid	MUTZ5	11
Haematopoietic and lymphoid	MV411	10.5
Haematopoietic and lymphoid	NALM19	9.8
Haematopoietic and lymphoid	NALM1	10.2
Haematopoietic and lymphoid	NALM6	10.2
Haematopoietic and lymphoid	NAMALWA	10.1
Haematopoietic and lymphoid	NB4	10.1
Haematopoietic and lymphoid	NCIH929	9.4
Haematopoietic and lymphoid	NCO2	10
Haematopoietic and lymphoid	NOMO1	9.4
Haematopoietic and lymphoid	NUDHL1	11
Haematopoietic and lymphoid	NUDUL1	10.1
Haematopoietic and lymphoid	OCIAML2	10.1
Haematopoietic and lymphoid	OCIAML3	11.6
Haematopoietic and lymphoid	OCIAML5	10.5
Haematopoietic and lymphoid	OCILY10	10.1
Haematopoietic and lymphoid	OCILY19	12.3
Haematopoietic and lymphoid	OCILY3	9.7
Haematopoietic and lymphoid	OCIM1	10
Haematopoietic and lymphoid	OPM2	9.5
Haematopoietic and lymphoid	P12ICHIKAWA	10.3
Haematopoietic and lymphoid	P31FUJ	9.8
Haematopoietic and lymphoid	P3HR1	9.5
Haematopoietic and lymphoid	PCM6	9.5
Haematopoietic and lymphoid	PEER	10.6
Haematopoietic and lymphoid	PF382	10.6
Haematopoietic and lymphoid	PFEIFFER	9.6
Haematopoietic and lymphoid	PL21	9.7
Haematopoietic and lymphoid	RAJI	9.4
Haematopoietic and lymphoid	RCHACV	9.5
Haematopoietic and lymphoid	REC1	9.4
Haematopoietic and lymphoid	REH	9.7
Haematopoietic and lymphoid	RI1	9.8
Haematopoietic and lymphoid	RL	9.1
Haematopoietic and lymphoid	RPMI8226	10.4
Haematopoietic and lymphoid	RPMI8402	10.7
Haematopoietic and lymphoid	RS411	9.4
Haematopoietic and lymphoid	SEM	9.9
Haematopoietic and lymphoid	SET2	10.2
Haematopoietic and lymphoid	SIGM5	10.3
Haematopoietic and lymphoid	SKM1	9.1
Haematopoietic and lymphoid	SKMM2	9.8
Haematopoietic and lymphoid	SR786	10.1
Haematopoietic and lymphoid	ST486	9.4
Haematopoietic and lymphoid	SUDHL10	10.4
Haematopoietic and lymphoid	SUDHL1	9.5
Haematopoietic and lymphoid	SUDHL4	10.4
Haematopoietic and lymphoid	SUDHL5	9.8
Haematopoietic and lymphoid	SUDHL6	9.1
Haematopoietic and lymphoid	SUDHL8	10.6
Haematopoietic and lymphoid	SUPB15	9.6
Haematopoietic and lymphoid	SUPHD1	11.6
Haematopoietic and lymphoid	SUPM2	10.6
Haematopoietic and lymphoid	SUPT11	11.4
Haematopoietic and lymphoid	SUPT1	10.1
Haematopoietic and lymphoid	TALL1	11.4
Haematopoietic and lymphoid	TF1	9.4
Haematopoietic and lymphoid	THP1	9.4
Haematopoietic and lymphoid	TO175T	8.9
Haematopoietic and lymphoid	TOLEDO	10.1
Haematopoietic and lymphoid	U266B1	9.5
Haematopoietic and lymphoid	U937	10
Haematopoietic and lymphoid	UT7	11.2
Haematopoietic and lymphoid	WSUDLCL2	9.4
Kidney	769P	9.4
Kidney	786O	9.3
Kidney	A498	9.7
Kidney	A704	10.4
Kidney	ACHN	9.4
Kidney	BFTC909	9.3
Kidney	CAKI1	9.7
Kidney	CAKI2	9.7
Kidney	CAL54	9.9
Kidney	KMRC1	9.6
Kidney	KMRC20	9.5
Kidney	KMRC2	10.4
Kidney	KMRC3	10.5
Kidney	OSRC2	9.6
Kidney	RCC10RGB	11
Kidney	SNU1272	9.9
Kidney	SNU349	10.6
Kidney	TUHR10TKB	10.4
Kidney	TUHR14TKB	9.9
Kidney	TUHR4TKB	10
Kidney	VMRCRCW	10.3
Kidney	VMRCRCZ	10.7
Large intestine	C2BBE1	9.3
Large intestine	CCK81	10.3
Large intestine	CL11	9.4
Large intestine	CL14	9.8
Large intestine	CL34	9.5
Large intestine	CL40	9.1
Large intestine	COLO205	8.6
Large intestine	COLO320	9.9
Large intestine	COLO678	9.3
Large intestine	CW2	9.1
Large intestine	DLD1	9
Large intestine	GP2D	9.3
Large intestine	HCC56	9.6
Large intestine	HCT116	8.8
Large intestine	HCT15	8.7
Large intestine	HS675T	8.1
Large intestine	HS698T	9.1
Large intestine	HT115	9.7
Large intestine	HT29	9.4
Large intestine	HT55	9.6
Large intestine	KM12	9.8
Large intestine	LOVO	8.7
Large intestine	LS1034	8.7
Large intestine	LS123	9
Large intestine	LS180	9.4
Large intestine	LS411N	9.2
Large intestine	LS513	8.4
Large intestine	MDST8	8.9
Large intestine	NCIH508	9.8
Large intestine	NCIH716	9.2
Large intestine	NCIH747	8.9
Large intestine	OUMS23	9.8
Large intestine	RCM1	10.3
Large intestine	RKO	9.1
Large intestine	SKCO1	8.9
Large intestine	SNU1040	8.3
Large intestine	SNU1197	9.3
Large intestine	SNU175	9.5
Large intestine	SNU283	9.2
Large intestine	SNU407	9.6
Large intestine	SNU503	10.4
Large intestine	SNU61	9.2
Large intestine	SNU81	9.9
Large intestine	SNUC1	9.1
Large intestine	SNUC2A	10.1
Large intestine	SNUC4	9.5
Large intestine	SNUC5	9.4
Large intestine	SW1116	9.5
Large intestine	SW1417	9.9
Large intestine	SW1463	9.1
Large intestine	SW403	9.5
Large intestine	SW480	9.1
Large intestine	SW48	10
Large intestine	SW620	8.6
Large intestine	SW837	9.4
Large intestine	SW948	11.2
Large intestine	T84	9.1
Liver	ALEXANDERCELLS	8.9
Liver	C3A	10.1
Liver	HEP3B217	9.7
Liver	HEPG2	10.3
Liver	HLE	9.4
Liver	HLF	9.9
Liver	HUH1	9.2
Liver	HUH6	9.7
Liver	HUH7	9.9
Liver	JHH1	10
Liver	JHH2	10.2
Liver	JHH4	9.5
Liver	JHH5	9.3
Liver	JHH6	9.7
Liver	JHH7	8.9
Liver	LI7	8.9
Liver	PLCPRF5	9.2
Liver	SKHEP1	9.2
Liver	SNU182	9.6
Liver	SNU387	10.2
Liver	SNU398	10.2
Liver	SNU423	10.4
Liver	SNU449	9
Liver	SNU475	9.4
Liver	SNU761	9.5
Liver	SNU878	9.2
Liver	SNU886	9.8
Lung	A549	9.1
Lung	ABC1	8.9
Lung	BEN	9.3
Lung	CAL12T	8.7
Lung	CALU1	9.4
Lung	CALU3	8.5
Lung	CALU6	9
Lung	CHAGOK1	8.8
Lung	COLO668	9.3
Lung	COLO699	10.5
Lung	CORL105	10
Lung	CORL23	8.5
Lung	CORL24	10.4
Lung	CORL279	11
Lung	CORL311	9.6
Lung	CORL47	10.4
Lung	CORL51	10.5
Lung	CORL88	10
Lung	CORL95	10.3
Lung	CPCN	9.1
Lung	DMS114	10.2
Lung	DMS153	10.2
Lung	DMS273	9.5
Lung	DMS454	9
Lung	DMS53	10
Lung	DMS79	10.3
Lung	DV90	4.2
Lung	EBC1	7.6
Lung	EPLC272H	9.3
Lung	HARA	8.3
Lung	HCC1171	10
Lung	HCC1195	9.2
Lung	HCC15	8.9
Lung	HCC2279	9.4
Lung	HCC2935	9.5
Lung	HCC33	9.8
Lung	HCC366	10.2
Lung	HCC4006	9.4
Lung	HCC44	8.6
Lung	HCC78	9.5
Lung	HCC827	10.2
Lung	HCC95	8.6
Lung	HLC1	9.6
Lung	HLFA	7.5
Lung	HS229T	8.5
Lung	HS618T	8
Lung	IALM	10.5
Lung	KNS62	8.1
Lung	LC1F	9.3
Lung	LC1SQSF	9
Lung	LCLC103H	9.4
Lung	LCLC97TM1	9.2
Lung	LK2	10.4
Lung	LOUNH91	9.2
Lung	LU65	8.6
Lung	LU99	9.5
Lung	LUDLU1	9.8
Lung	LXF289	10
Lung	MORCPR	9.2
Lung	NCIH1048	8.1
Lung	NCIH1092	9.3
Lung	NCIH1105	10.3
Lung	NCIH1155	8.9
Lung	NCIH1184	10.2
Lung	NCIH1299	10.2
Lung	NCIH1339	10.3
Lung	NCIH1341	10.1
Lung	NCIH1355	9.7
Lung	NCIH1373	9.9
Lung	NCIH1385	10.7
Lung	NCIH1395	9.1
Lung	NCIH1435	9.1
Lung	NCIH1436	10.1
Lung	NCIH1437	8.7
Lung	NCIH146	9.9
Lung	NCIH1563	9.4
Lung	NCIH1568	8.7
Lung	NCIH1573	9.7
Lung	NCIH1581	10.1
Lung	NCIH1618	10.3
Lung	NCIH1623	9.7
Lung	NCIH1648	9.9
Lung	NCIH1650	9.7
Lung	NCIH1651	8.6
Lung	NCIH1666	9.8
Lung	NCIH1693	9.8
Lung	NCIH1694	10
Lung	NCIH1703	9.3
Lung	NCIH1734	9.3
Lung	NCIH1755	9.9
Lung	NCIH1781	9.2
Lung	NCIH1792	9.4
Lung	NCIH1793	10.2
Lung	NCIH1836	10.1
Lung	NCIH1838	9.2
Lung	NCIH1869	8.7
Lung	NCIH1876	10.3
Lung	NCIH1915	9.9
Lung	NCIH1930	10
Lung	NCIH1944	7.7
Lung	NCIH1963	10
Lung	NCIH196	8.9
Lung	NCIH1975	9.8
Lung	NCIH2009	10
Lung	NCIH2023	9.2
Lung	NCIH2029	9.7
Lung	NCIH2030	9.9
Lung	NCIH2066	9.7
Lung	NCIH2081	10
Lung	NCIH2085	9.6
Lung	NCIH2087	9.3
Lung	NCIH209	9.7
Lung	NCIH2106	9.6
Lung	NCIH2110	8.8
Lung	NCIH211	9.6
Lung	NCIH2122	8.2
Lung	NCIH2126	8.8
Lung	NCIH2141	10.8
Lung	NCIH2170	9.1
Lung	NCIH2171	10.3
Lung	NCIH2172	9.1
Lung	NCIH2196	9.2
Lung	NCIH2227	9.9
Lung	NCIH2228	9.5
Lung	NCIH226	8.6
Lung	NCIH2286	10.2
Lung	NCIH2291	9.6
Lung	NCIH2342	9.1
Lung	NCIH2347	9.2
Lung	NCIH23	11
Lung	NCIH2405	9.4
Lung	NCIH2444	9.3
Lung	NCIH292	8.3
Lung	NCIH322	9.4
Lung	NCIH3255	9.3
Lung	NCIH358	10
Lung	NCIH441	10
Lung	NCIH446	9.6
Lung	NCIH460	8.5
Lung	NCIH510	10.1
Lung	NCIH520	9.6
Lung	NCIH522	10.6
Lung	NCIH524	9.9
Lung	NCIH526	9.9
Lung	NCIH596	9.3
Lung	NCIH647	8.9
Lung	NCIH650	10.5
Lung	NCIH661	9.1
Lung	NCIH69	9.2
Lung	NCIH727	9.5
Lung	NCIH810	9.7
Lung	NCIH82	9.6
Lung	NCIH838	9.6
Lung	NCIH841	10.1
Lung	NCIH854	11
Lung	NCIH889	10.5
Lung	PC14	8.8
Lung	RERFLCAD1	10
Lung	RERFLCAD2	9.1
Lung	RERFLCAI	8.3
Lung	RERFLCKJ	8.5
Lung	RERFLCMS	9.4
Lung	RERFLCSQ1	10
Lung	SBC5	10.1
Lung	SCLC21H	10.1
Lung	SHP77	9.1
Lung	SKLU1	9.4
Lung	SKMES1	9.5
Lung	SQ1	9.4
Lung	SW1271	9.3
Lung	SW1573	9.2
Lung	SW900	8.8
Lung	VMRCLCD	9.3
Lung	VMRCLCP	8.8
Oesophagus	COLO680N	9
Oesophagus	ECGI10	10
Oesophagus	KYSE140	9.3
Oesophagus	KYSE150	8.3
Oesophagus	KYSE180	9.2
Oesophagus	KYSE270	10.6
Oesophagus	KYSE30	9.9
Oesophagus	KYSE410	9.5
Oesophagus	KYSE450	9.6
Oesophagus	KYSE510	10.1
Oesophagus	KYSE520	9.8
Oesophagus	KYSE70	9.5
Oesophagus	OE19	9.6
Oesophagus	OE33	10.5
Oesophagus	TE10	10
Oesophagus	TE11	9.4
Oesophagus	TE14	9.3
Oesophagus	TE15	8.7
Oesophagus	TE1	8.7
Oesophagus	TE4	9.4
Oesophagus	TE5	9.2
Oesophagus	TE6	9.7
Oesophagus	TE8	9.6
Oesophagus	TE9	9.1
Oesophagus	TT	11
Ovary	59M	9.1
Ovary	A2780	9.9
Ovary	CAOV3	9.1
Ovary	CAOV4	10.1
Ovary	COLO704	10.1
Ovary	COV318	10.2
Ovary	COV362	9.1
Ovary	COV434	9.7
Ovary	COV504	9
Ovary	COV644	9.1
Ovary	EFO21	9.7
Ovary	EFO27	10.3
Ovary	ES2	9.2
Ovary	FUOV1	10.2
Ovary	HEYA8	8.9
Ovary	HS571T	9.2
Ovary	IGROV1	10.2
Ovary	JHOC5	10.2
Ovary	JHOM1	10.1
Ovary	JHOM2B	9.4
Ovary	JHOS2	9.9
Ovary	JHOS4	10.2
Ovary	KURAMOCHI	10.3
Ovary	MCAS	9.3
Ovary	NIHOVCAR3	9.3
Ovary	OAW28	10.1
Ovary	OAW42	8.8
Ovary	OC314	9.3
Ovary	OC316	9.6
Ovary	ONCODG1	9.4
Ovary	OV56	10
Ovary	OV7	9.4
Ovary	OV90	9.2
Ovary	OVCAR4	9.8
Ovary	OVCAR8	9.5
Ovary	OVISE	9.5
Ovary	OVK18	8.8
Ovary	OVKATE	9.6
Ovary	OVMANA	9.9
Ovary	OVSAHO	9.9
Ovary	OVTOKO	10.3
Ovary	RMGI	9.5
Ovary	RMUGS	8.1
Ovary	SKOV3	9.2
Ovary	SNU119	9.9
Ovary	SNU840	9.9
Ovary	SNU8	9.4
Ovary	TOV112D	10.6
Ovary	TOV21G	9.7
Ovary	TYKNU	9.7
Pancreas	ASPC1	10.3
Pancreas	BXPC3	8.4
Pancreas	CAPAN1	9.2
Pancreas	CAPAN2	8.9
Pancreas	CFPAC1	9.4
Pancreas	DANG	8.6
Pancreas	HPAC	9.8
Pancreas	HPAFII	10
Pancreas	HS766T	8.8
Pancreas	HUPT3	8.9
Pancreas	HUPT4	9.1
Pancreas	KCIMOH1	9.8
Pancreas	KLM1	9.1
Pancreas	KP2	9.7
Pancreas	KP3	9.5
Pancreas	KP4	9.6
Pancreas	L33	8.9
Pancreas	MIAPACA2	9.4
Pancreas	PANC0203	9.9
Pancreas	PANC0213	10.1
Pancreas	PANC0327	9.4
Pancreas	PANC0403	9.1
Pancreas	PANC0504	9.6
Pancreas	PANC0813	9.4
Pancreas	PANC1005	9.5
Pancreas	PANC1	9.6
Pancreas	PATU8902	9.3
Pancreas	PATU8988S	9.5
Pancreas	PATU8988T	9.5
Pancreas	PK1	8.7
Pancreas	PK45H	8.9
Pancreas	PK59	9.3
Pancreas	PL45	9.9
Pancreas	PSN1	9.7
Pancreas	QGP1	9.6
Pancreas	SNU213	9.6
Pancreas	SNU324	9
Pancreas	SNU410	9.5
Pancreas	SU8686	9.3
Pancreas	SUIT2	8.3
Pancreas	SW1990	9.1
Pancreas	T3M4	8
Pancreas	TCCPAN2	9.5
Pancreas	YAPC	9.6
Pleura	ACCMESO1	8.9
Pleura	DM3	8.1
Pleura	ISTMES1	8.2
Pleura	ISTMES2	9.5
Pleura	JL1	9.6
Pleura	MPP89	9.4
Pleura	MSTO211H	9.3
Pleura	NCIH2052	10.4
Pleura	NCIH2452	9.5
Pleura	NCIH28	10.6
Prostate	22RV1	8.8
Prostate	DU145	9.4
Prostate	LNCAPCLONEFGC	9.5
Prostate	MDAPCA2B	9.1
Prostate	NCIH660	10.4
Prostate	PC3	9.9
Prostate	VCAP	8.6
Salivary gland	A253	10
Salivary gland	YD15	9.8
Skin	A101D	9.6
Skin	A2058	9.4
Skin	A375	9.6
Skin	C32	10.5
Skin	CHL1	9.8
Skin	CJM	9.5
Skin	COLO679	9.7
Skin	COLO741	9.7
Skin	COLO783	10
Skin	COLO792	9.5
Skin	COLO800	10
Skin	COLO818	9.7
Skin	COLO829	10.1
Skin	COLO849	10.7
Skin	G361	9.4
Skin	GRM	9.4
Skin	HMCB	9.9
Skin	HS294T	9.8
Skin	HS600T	8.5
Skin	HS688AT	9.7
Skin	HS695T	10.1
Skin	HS839T	8.2
Skin	HS852T	10.1
Skin	HS895T	8.7
Skin	HS934T	8.4
Skin	HS936T	9.9
Skin	HS939T	9.6
Skin	HS940T	9
Skin	HS944T	9.7
Skin	HT144	10
Skin	IGR1	10.3
Skin	IGR37	10.3
Skin	IGR39	9.1
Skin	IPC298	9.9
Skin	K029AX	9.8
Skin	LOXIMVI	9.5
Skin	MALME3M	9.7
Skin	MDAMB435S	9.8
Skin	MELHO	9.5
Skin	MELJUSO	9.4
Skin	MEWO	10.2
Skin	RPMI7951	9
Skin	RVH421	10.3
Skin	SH4	11
Skin	SKMEL1	9.6
Skin	SKMEL24	10.6
Skin	SKMEL28	10.3
Skin	SKMEL2	10.7
Skin	SKMEL30	9.8
Skin	SKMEL31	9.4
Skin	SKMEL3	9.6
Skin	SKMEL5	9.8
Skin	UACC257	9.7
Skin	UACC62	9.9
Skin	WM115	10.1
Skin	WM1799	9.9
Skin	WM2664	10.2
Skin	WM793	8.9
Skin	WM88	9.6
Skin	WM983B	10.3
Small intestine	HUTU80	9.1
Soft tissue	A204	8.3
Soft tissue	G401	9.5
Soft tissue	G402	9.7
Soft tissue	GCT	9.2
Soft tissue	HS729	9.8
Soft tissue	HT1080	9.6
Soft tissue	KYM1	9
Soft tissue	MESSA	10.2
Soft tissue	RD	10.2
Soft tissue	RH30	9.3
Soft tissue	RH41	9.5
Soft tissue	RKN	9.2
Soft tissue	S117	10.1
Soft tissue	SJRH30	10
Soft tissue	SKLMS1	9.2
Soft tissue	SKUT1	10.6
Soft tissue	TE125T	8.7
Soft tissue	TE159T	8.8
Soft tissue	TE441T	10.5
Soft tissue	TE617T	9.9
Stomach	2313287	9.1
Stomach	AGS	9.2
Stomach	AZ521	8.4
Stomach	ECC10	10.8
Stomach	ECC12	9.1
Stomach	FU97	8.5
Stomach	GCIY	9.2
Stomach	GSS	9.4
Stomach	GSU	9.7
Stomach	HGC27	9.9
Stomach	HS746T	10
Stomach	HUG1N	9.5
Stomach	IM95	8.9
Stomach	KATOIII	8.9
Stomach	KE39	9.8
Stomach	LMSU	10.1
Stomach	MKN1	9.2
Stomach	MKN45	9.5
Stomach	MKN74	9.7
Stomach	MKN7	9.6
Stomach	NCCSTCK140	10.2
Stomach	NCIN87	9.2
Stomach	NUGC2	9.7
Stomach	NUGC3	9.6
Stomach	NUGC4	9.8
Stomach	OCUM1	8.9
Stomach	RERFGC1B	10.1
Stomach	SH10TC	8.2
Stomach	SNU16	8.6
Stomach	SNU1	10.2
Stomach	SNU216	9
Stomach	SNU520	9.9
Stomach	SNU5	9.2
Stomach	SNU601	8.8
Stomach	SNU620	9.4
Stomach	SNU668	8.9
Stomach	SNU719	9.9
Stomach	TGBC11TKB	10.2
Thyroid	8305C	9.5
Thyroid	8505C	9.4
Thyroid	BCPAP	10.1
Thyroid	BHT101	9.3
Thyroid	CAL62	10.1
Thyroid	CGTHW1	8.9
Thyroid	FTC133	8.6
Thyroid	FTC238	8.9
Thyroid	ML1	10.1
Thyroid	SW579	8.6
Thyroid	TT2609C02	8.9
Thyroid	TT	9
Upper aerodigestive tract	BHY	9.5
Upper aerodigestive tract	BICR16	9.1
Upper aerodigestive tract	BICR18	8.8
Upper aerodigestive tract	BICR22	9.5
Upper aerodigestive tract	BICR31	8.9
Upper aerodigestive tract	BICR56	10
Upper aerodigestive tract	BICR6	9.7
Upper aerodigestive tract	CAL27	9.7
Upper aerodigestive tract	CAL33	9.2
Upper aerodigestive tract	DETROIT562	8.5
Upper aerodigestive tract	FADU	9.4
Upper aerodigestive tract	HS840T	8.1
Upper aerodigestive tract	HSC2	9.6
Upper aerodigestive tract	HSC3	9.4
Upper aerodigestive tract	HSC4	9.9
Upper aerodigestive tract	PECAPJ15	9
Upper aerodigestive tract	PECAPJ34CLONEC12	8.8
Upper aerodigestive tract	PECAPJ41CLONED2	10
Upper aerodigestive tract	PECAPJ49	8.4
Upper aerodigestive tract	SCC15	9.8
Upper aerodigestive tract	SCC25	9.4
Upper aerodigestive tract	SCC4	9.8
Upper aerodigestive tract	SCC9	10.1
Upper aerodigestive tract	SNU1076	9.5
Upper aerodigestive tract	SNU1214	9.5
Upper aerodigestive tract	SNU46	9.5
Upper aerodigestive tract	SNU899	9.9
Upper aerodigestive tract	YD10B	10.1
Upper aerodigestive tract	YD38	8.6
Upper aerodigestive tract	YD8	9.2
Urinary tract	5637	9.2
Urinary tract	639V	9.1
Urinary tract	647V	8.5
Urinary tract	BC3C	9.3
Urinary tract	BFTC905	9.3
Urinary tract	CAL29	9.8
Urinary tract	HS172T	8.1
Urinary tract	HT1197	8.3
Urinary tract	HT1376	9.1
Urinary tract	J82	8.5
Urinary tract	JMSU1	9.6
Urinary tract	KMBC2	9.5
Urinary tract	KU1919	10.7
Urinary tract	RT11284	9.2
Urinary tract	RT112	9.4
Urinary tract	RT4	8.6
Urinary tract	SCABER	9.7
Urinary tract	SW1710	9.8
Urinary tract	SW780	9.1
Urinary tract	T24	9.3
Urinary tract	TCCSUP	7.8
Urinary tract	UMUC1	8.8
Urinary tract	UMUC3	10.7
Urinary tract	VMCUB1	9.7

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	13.7
Adrenal gland	15.5
Appendix	18
Bone marrow	43.6
Breast	24.7
Cerebral cortex	28.4
Cervix, uterine	23.9
Colon	14.9
Duodenum	19.6
Endometrium	33.7
Epididymis	21.5
Esophagus	21.4
Fallopian tube	26.1
Gallbladder	25.1
Heart muscle	14.1
Kidney	14.8
Liver	6.7
Lung	25
Lymph node	20.9
Ovary	26.2
Pancreas	3.3
Parathyroid gland	26.5
Placenta	31
Prostate	27.2
Rectum	17.7
Salivary gland	5.7
Seminal vesicle	27
Skeletal muscle	5.5
Skin	37.2
Small intestine	21.2
Smooth muscle	22.2
Spleen	25.6
Stomach	13.7
Testis	93.2
Thyroid gland	33.5
Tonsil	18.6
Urinary bladder	17.3

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
27472901	Underexpression	Breast Carcinoma	Finally, we find defective KDM3A expression in human breast cancer cell lines and tumors.
27034728	Overexpression	Breast Carcinoma	A breast cancer transformation model was established via stably expressing three oncogenes in primary breast epithelial cells. Chromatin immunoprecipitation followed by the next-generation sequencing of histone methylations was performed to determine epigenetic events during transformation. KDM3A/JMJD1A, a demethylase for H3K9me1 and me2, gradually increases during cancer transformation and is elevated in patient tissues.
26945572	Overexpression	Non-Small Cell Lung Carcinoma	In the present study, JMJD1A was frequently upregulated in NSCLC compared with para-carcinoma tissues.
26617828	Overexpression	Gastric Carcinoma	JMJD1A was found to be upregulated in gastric cancer tissues and cell lines.
25071150	Underexpression	seminoma; yolk sac tumor; embryonal carcinoma	We reveal a striking downregulation of the hypoxia-inducible histone H3 lysine 9 (H3K9) demethylase JMJD1A as a hallmark of clinical human germ cell-derived tumors, such as seminomas, yolk sac tumors, and embryonal carcinomas.
24742640	Overexpression	Neuroblastoma	Here we demonstrated that N-Myc up-regulated the expression of JMJD1A in N-Myc oncogene-amplified human neuroblastoma cells by directly binding to the JMJD1A gene promoter.
24362521	Overexpression	Ewing Sarcoma	We show that KDM3A is overexpressed in Ewing Sarcoma, and that its depletion inhibits clonogenic and anchorage-independent growth in multiple patient-derived cell lines, and tumorigenesis in a xenograft model.
23884959	Overexpression	Prostate Carcinoma	This study showed that pathological hypoxia (<0.5% O2) increased the expression of androgen receptor (AR) target genes such as prostate-specific antigen (PSA) and kallikrein-related peptidase 2 in LNCaP human prostate cancer cells by modifying the quantity and activity of related Jumonji C domain-containing histone demethylases (JMJDs). Furthermore, hypoxia increased the expression of JMJD1A. Hypoxia and androgen additively increased the recruitment of JMJD1A and p300 on the enhancer region of PSA through interaction with the hypoxia-inducible factor-1α and AR, both of which bind the PSA enhancer.
22120715	Overexpression	Prostate Carcinoma	Our results show that the KDMs JARID1B, PHF8, KDM3A, KDM3B and KDM4A were highly expressed in clinical PrCa samples.
22020899	Overexpression	Bladder Carcinoma; Lung Carcinoma	Expression levels of KDM3A were significantly elevated in human bladder carcinomas compared with nonneoplastic bladder tissues (p < 0.0001), when assessed by real-time PCR. We confirmed that some other cancers including lung cancer also overexpressed KDM3A, using cDNA microarray analysis.
21607773	Overexpression	Hepatocellular Carcinoma	We examined Jumonji domain containing 1A expression in 110 hepatocellular carcinoma samples with quantitative real-time polymerase chain reaction and immunohistochemistry. The level of Jumonji domain containing 1A in cancer tissues was higher than in normal tissues (P < 0.0001). Protein expression was significantly related to gene expression (P < 0.0001).
21541331	Underexpression	Nasopharyngeal Carcinoma	Taken together, up-regulation of miR-155 in NPC is partly driven by LMP1 and LMP2A, and results in downregulation of JMJD1A, which is associated with N stage and poor prognosis of NPC patients.
21275466	Overexpression	Renal Cell Carcinoma	The expression of JMJD1A was determined in 10 kidney cancer tissue and adjacent tissue by quantitative polymerase chain reaction, western blotting and immunohistochemistry. The expression of JMJD1A was higher in cancer tissue than adjacent tissue, and in hypoxic environment than normal environment.
18984585	Overexpression	Renal Cell Carcinoma	Furthermore, we find increased expression of JMJD1A and JMJD2B in renal cancer cells that have lost the von Hippel Lindau tumor suppressor protein VHL and therefore display a deregulated expression of hypoxia-inducible factor.
27835890	Overexpression	Cervical Carcinoma	Here, we showed that the expression of JMJD1A is increased in cervical cancer cells and tissues, and that suppression of JMJD1A inhibits proliferation, migration, and invasion of cervical cancer cells.

Summary
Symbol	KDM3A
Name	lysine demethylase 3A
Aliases	TSGA; KIAA0742; JHMD2A; jumonji C domain-containing histone demethylase 2A; JMJD1; JMJD1A; jumonji domain co ......
Location	2p11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.234	2.02e-06	8.2	61.6	30.2	Neutral
BRCA	Breast invasive carcinoma	1075	0.315	3.24e-26	15.3	69.7	15	Neutral
CESC	Cervical and endocervical cancers	292	0.234	5.53e-05	5.5	72.9	21.6	Neutral
COAD	Colon adenocarcinoma	449	0.266	9.83e-09	2	80.8	17.1	Neutral
ESCA	Esophageal carcinoma	183	0.328	6.03e-06	5.5	56.3	38.3	Gain
GBM	Glioblastoma multiforme	147	0.12	0.147	5.4	86.4	8.2	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.218	6.35e-07	5.8	74.3	19.8	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.317	9.99e-14	2.5	83.2	14.3	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.258	9.43e-06	2.8	82.6	14.6	Neutral
LAML	Acute Myeloid Leukemia	166	0.015	0.851	0	99.4	0.6	Neutral
LGG	Brain Lower Grade Glioma	513	0.101	0.0221	3.9	93.6	2.5	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.209	5.81e-05	9.6	78.3	12.1	Neutral
LUAD	Lung adenocarcinoma	512	0.271	4.53e-10	4.7	65.2	30.1	Neutral
LUSC	Lung squamous cell carcinoma	498	0.412	8.51e-22	3.6	51.8	44.6	Gain
OV	Ovarian serous cystadenocarcinoma	300	0.507	5.1e-21	10.7	55	34.3	Gain
PAAD	Pancreatic adenocarcinoma	177	0.315	1.9e-05	5.1	86.4	8.5	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.352	4.51e-06	6.8	90.1	3.1	Neutral
PRAD	Prostate adenocarcinoma	491	0.223	6.3e-07	5.9	90.6	3.5	Neutral
READ	Rectum adenocarcinoma	164	0.335	1.17e-05	7.9	70.1	22	Neutral
SARC	Sarcoma	255	0.416	4.11e-12	22.7	54.5	22.7	Neutral
SKCM	Skin Cutaneous Melanoma	367	0.264	2.97e-07	13.9	68.1	18	Neutral
STAD	Stomach adenocarcinoma	413	0.175	0.000341	4.4	76.5	19.1	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.156	0.0567	6	62.7	31.3	Neutral
THCA	Thyroid carcinoma	497	0.108	0.0158	1.8	97.8	0.4	Neutral
THYM	Thymoma	119	-0.149	0.107	0.8	98.3	0.8	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.28	3.77e-11	2.4	79.7	17.9	Neutral

Summary
Symbol	KDM3A
Name	lysine demethylase 3A
Aliases	TSGA; KIAA0742; JHMD2A; jumonji C domain-containing histone demethylase 2A; JMJD1; JMJD1A; jumonji domain co ......
Location	2p11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.211	1.19e-05	17	408	-0.007	0.0802	NS/NA
BRCA	Breast invasive carcinoma	-0.265	2.72e-15	83	785	-0.001	0.318	NS/NA
CESC	Cervical and endocervical cancers	-0.15	0.0081	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.151	0.00739	19	297	-0.002	0.242	NS/NA
ESCA	Esophageal carcinoma	-0.183	0.0107	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.285	0.0215	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.212	6.93e-07	20	522	-0.002	0.0319	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.199	0.000207	24	319	0.012	7.52e-06	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.107	0.0651	23	275	-0.035	1.3e-13	NS/NA
LAML	Acute Myeloid Leukemia	-0.112	0.146	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.218	4.32e-07	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.115	0.0192	41	373	0.018	1.03e-18	NS/NA
LUAD	Lung adenocarcinoma	-0.164	0.000315	21	456	0.011	0.551	NS/NA
LUSC	Lung squamous cell carcinoma	-0.169	0.00101	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.767	0.0214	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.127	0.0873	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.257	0.000393	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.317	9.12e-14	35	498	0.015	0.0161	NS/NA
READ	Rectum adenocarcinoma	-0.198	0.0478	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.303	6.31e-07	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.27	3.05e-09	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.298	5.57e-09	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.158	0.0488	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.151	0.000338	50	509	-0.001	0.00606	NS/NA
THYM	Thymoma	-0.19	0.0365	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.34	6.03e-14	34	431	-0.005	2.21e-05	NS/NA

Summary
Symbol	KDM3A
Name	lysine demethylase 3A
Aliases	TSGA; KIAA0742; JHMD2A; jumonji C domain-containing histone demethylase 2A; JMJD1; JMJD1A; jumonji domain co ......
Location	2p11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA) [ TOP ]
There is no antibody staining data.

Summary
Symbol	KDM3A
Name	lysine demethylase 3A
Aliases	TSGA; KIAA0742; JHMD2A; jumonji C domain-containing histone demethylase 2A; JMJD1; JMJD1A; jumonji domain co ......
Location	2p11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.0606	NS	24476821
BRCA	Breast invasive carcinoma	521	0.00139	Significant	23000897
COAD	Colon adenocarcinoma	149	0.917	NS	22810696
GBM	Glioblastoma multiforme	157	0.393	NS	26824661
HNSC	Head and Neck squamous cell carcinoma	279	1.17e-07	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.701	NS	26536169
LGG	Brain Lower Grade Glioma	513	2.65e-12	Significant	26824661
LUAD	Lung adenocarcinoma	230	0.00711	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	3.62e-09	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	1.19e-05	Significant	21720365
PRAD	Prostate adenocarcinoma	333	0.000892	Significant	26544944
READ	Rectum adenocarcinoma	67	0.0162	Significant	22810696
SKCM	Skin Cutaneous Melanoma	315	0.00387	Significant	26091043
STAD	Stomach adenocarcinoma	277	0.000158	Significant	25079317
THCA	Thyroid carcinoma	391	2.7e-05	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.132	NS	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	0.714	0.112	NS
BRCA	Breast invasive carcinoma	1079	1.282	0.283	NS
CESC	Cervical and endocervical cancers	291	2.086	0.037	Shorter
COAD	Colon adenocarcinoma	439	2.044	0.0138	Shorter
ESCA	Esophageal carcinoma	184	1	0.999	NS
GBM	Glioblastoma multiforme	158	0.816	0.422	NS
HNSC	Head and Neck squamous cell carcinoma	518	0.923	0.679	NS
KIRC	Kidney renal clear cell carcinoma	531	0.736	0.141	NS
KIRP	Kidney renal papillary cell carcinoma	287	1.797	0.148	NS
LAML	Acute Myeloid Leukemia	149	0.382	0.00256	Longer
LGG	Brain Lower Grade Glioma	511	0.914	0.727	NS
LIHC	Liver hepatocellular carcinoma	365	2.013	0.00508	Shorter
LUAD	Lung adenocarcinoma	502	1.026	0.902	NS
LUSC	Lung squamous cell carcinoma	494	0.828	0.354	NS
OV	Ovarian serous cystadenocarcinoma	303	1.476	0.0634	NS
PAAD	Pancreatic adenocarcinoma	177	1.884	0.0338	Shorter
PCPG	Pheochromocytoma and Paraganglioma	179	1575811044.929	0.0534	NS
PRAD	Prostate adenocarcinoma	497	1.338	0.772	NS
READ	Rectum adenocarcinoma	159	1.412	0.57	NS
SARC	Sarcoma	259	1.047	0.873	NS
SKCM	Skin Cutaneous Melanoma	459	1.101	0.627	NS
STAD	Stomach adenocarcinoma	388	0.779	0.26	NS
TGCT	Testicular Germ Cell Tumors	134	1.128	0.932	NS
THCA	Thyroid carcinoma	500	0.717	0.685	NS
THYM	Thymoma	119	0.475	0.282	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	1.542	0.14	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	-0.062	0.215	NS
BRCA	Breast invasive carcinoma	1071	-0.051	0.0979	NS
CESC	Cervical and endocervical cancers	167	0.169	0.0293	Higher
COAD	Colon adenocarcinoma	445	0.081	0.0887	NS
ESCA	Esophageal carcinoma	162	-0.122	0.121	NS
HNSC	Head and Neck squamous cell carcinoma	448	0.059	0.213	NS
KIRC	Kidney renal clear cell carcinoma	531	0.037	0.394	NS
KIRP	Kidney renal papillary cell carcinoma	260	0.064	0.303	NS
LIHC	Liver hepatocellular carcinoma	347	0.202	0.000149	Higher
LUAD	Lung adenocarcinoma	507	0.041	0.36	NS
LUSC	Lung squamous cell carcinoma	497	-0.006	0.896	NS
OV	Ovarian serous cystadenocarcinoma	302	-0.162	0.00488	Lower
PAAD	Pancreatic adenocarcinoma	176	0.09	0.237	NS
READ	Rectum adenocarcinoma	156	0.13	0.107	NS
SKCM	Skin Cutaneous Melanoma	410	-0.119	0.0161	Lower
STAD	Stomach adenocarcinoma	392	0.004	0.936	NS
TGCT	Testicular Germ Cell Tumors	81	-0.091	0.422	NS
THCA	Thyroid carcinoma	499	-0.036	0.42	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.101	0.0235	Higher

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	-0.079	0.192	NS
HNSC	Head and Neck squamous cell carcinoma	498	0.05	0.268	NS
KIRC	Kidney renal clear cell carcinoma	525	-0.084	0.0557	NS
LGG	Brain Lower Grade Glioma	514	-0.054	0.225	NS
LIHC	Liver hepatocellular carcinoma	366	0.051	0.327	NS
OV	Ovarian serous cystadenocarcinoma	296	0.008	0.887	NS
PAAD	Pancreatic adenocarcinoma	176	0.118	0.118	NS
STAD	Stomach adenocarcinoma	406	-0.058	0.245	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.144	0.000828	Higher

Summary
Symbol	KDM3A
Name	lysine demethylase 3A
Aliases	TSGA; KIAA0742; JHMD2A; jumonji C domain-containing histone demethylase 2A; JMJD1; JMJD1A; jumonji domain co ......
Location	2p11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	KDM3A
Name	lysine demethylase 3A
Aliases	TSGA; KIAA0742; JHMD2A; jumonji C domain-containing histone demethylase 2A; JMJD1; JMJD1A; jumonji domain co ......
Location	2p11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for KDM3A.

Summary
Symbol	KDM3A
Name	lysine demethylase 3A
Aliases	TSGA; KIAA0742; JHMD2A; jumonji C domain-containing histone demethylase 2A; JMJD1; JMJD1A; jumonji domain co ......
Location	2p11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
27472901	Breast Carcinoma	downstream	BNIP3; BNIP3L	Positive regulation	We find that KDM3A promotes anoikis through transcriptional activation of BNIP3 and BNIP3L, which encode pro-apoptotic proteins.
27034728	Breast Carcinoma	downstream	MYC; PAX3	Regulation	Genome-wide ChIP-seq analysis reveals that the boundaries of decreased H3K9me2 large organized chromatin K9 modifications (LOCKs) are enriched with cancer-related genes, such as MYC and PAX3. Further studies show that KDM3A/JMJD1A directly binds to these oncogenes and regulates their transcription by removing H3K9me2 mark.
26945572	Non-Small Cell Lung Carcinoma	downstream	EZH2; let-7c	Positive regulation; negative regulation	Further experiments demonstrated that JMJD1A knockdown could decrease the expression of EZH2, which has been shown to play a crucial role in the carcinogenesis of NSCLC and, in turn, increase the expression of anti-tumor microRNA let-7c.
26617828	Gastric Carcinoma	downstream	MAPK pathway; MALAT1	Positive regulation	In addition, in vitro experiment revealed that knockdown of JMJD1A expression inhibited the gastric cancer cell proliferation, and further study suggested that JMJD1A knockdown suppressed MAPK pathway via transcriptional downregulation the expression of long noncoding RNA MALAT1.
25071150	seminoma; yolk sac tumor; embryonal carcinoma	partner	G9a	Collaboration	Finally, Jmjd1a and G9a drive mutually opposing expression of the antiangiogenic factor genes Robo4, Igfbp4, Notch4, and Tfpi accompanied by changes in H3K9 methylation status.
25071150	seminoma; yolk sac tumor; embryonal carcinoma	downstream	Robo4; Igfbp4; Notch4; Tfpi	Regulation	Finally, Jmjd1a and G9a drive mutually opposing expression of the antiangiogenic factor genes Robo4, Igfbp4, Notch4, and Tfpi accompanied by changes in H3K9 methylation status.
24742640	Neuroblastoma	upstream	MALAT1	Positive regulation	Affymetrix microarray studies revealed that the gene second most significantly up-regulated by JMJD1A was MALAT1.
24362521	Ewing Sarcoma	upstream	miR-22	Negative regulation	Here we show that miR-22, an EWS/Fli1-repressed miR, is inhibitory to Ewing Sarcoma clonogenic and anchorage-independent cell growth, even at modest overexpression levels. Our studies further identify the H3K9me1/2 histone demethylase KDM3A (JMJD1A/JHDM2A) as a new miR-22-regulated gene. We show that KDM3A is overexpressed in Ewing Sarcoma, and that its depletion inhibits clonogenic and anchorage-independent growth in multiple patient-derived cell lines, and tumorigenesis in a xenograft model.
23884959	Prostate Carcinoma	partner	AR; hypoxia-inducible factor-1α	interaction	Furthermore, hypoxia increased the expression of JMJD1A. Hypoxia and androgen additively increased the recruitment of JMJD1A and p300 on the enhancer region of PSA through interaction with the hypoxia-inducible factor-1α and AR, both of which bind the PSA enhancer.
22020899	Bladder Carcinoma; Lung Carcinoma	downstream	HOXA1	Positive regulation	Importantly, we found that KDM3A activates transcription of the HOXA1 gene through demethylating histone H3 at lysine 9 di-methylation by binding to its promoter region.
21541331	Nasopharyngeal Carcinoma	upstream	miR-155	Negative regulation	Taken together, up-regulation of miR-155 in NPC is partly driven by LMP1 and LMP2A, and results in downregulation of JMJD1A, which is associated with N stage and poor prognosis of NPC patients.
18984585	Renal Cell Carcinoma	upstream	HIF-1alpha	Positive regulation	Here we show that the hypoxia-inducible factor HIF-1alpha binds to specific recognition sites in the genes encoding the jumonji family histone demethylases JMJD1A and JMJD2B and induces their expression.
27835890	Cervical Carcinoma	partner	c-Myc	Positive correlation	JMJD1A protein levels correlated with c-Myc expression (P<0.001), and high co-expression of the two proteins correlated with a poor prognosis.