CR2Cancer

Summary
Symbol	KDM4A
Name	lysine demethylase 4A
Aliases	KIAA0677; JHDM3A; TDRD14A; jumonji C domain-containing histone demethylase 3A; tudor domain containing 14A; ......
Location	1p34.2-p34.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

[ TOP ]

Domain

PF02373 JmjC domain
PF02375 jmjN domain

Function

Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively.; FUNCTION: Isoform 2: Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain.

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification erase	Histone methylation	H3K4me3, H3K36me3	H3K4me2, H3K36me2	16603238

> Gene Ontology [ TOP ]
Biological Process	GO:0003012 muscle system process GO:0003299 muscle hypertrophy in response to stress GO:0003300 cardiac muscle hypertrophy GO:0006479 protein methylation GO:0006482 protein demethylation GO:0006914 autophagy GO:0008213 protein alkylation GO:0008214 protein dealkylation GO:0009991 response to extracellular stimulus GO:0010001 glial cell differentiation GO:0010506 regulation of autophagy GO:0010507 negative regulation of autophagy GO:0010720 positive regulation of cell development GO:0010721 negative regulation of cell development GO:0014013 regulation of gliogenesis GO:0014014 negative regulation of gliogenesis GO:0014887 cardiac muscle adaptation GO:0014888 striated muscle adaptation GO:0014896 muscle hypertrophy GO:0014897 striated muscle hypertrophy GO:0014898 cardiac muscle hypertrophy in response to stress GO:0016570 histone modification GO:0016571 histone methylation GO:0016577 histone demethylation GO:0018022 peptidyl-lysine methylation GO:0018023 peptidyl-lysine trimethylation GO:0018205 peptidyl-lysine modification GO:0031056 regulation of histone modification GO:0031057 negative regulation of histone modification GO:0031060 regulation of histone methylation GO:0031061 negative regulation of histone methylation GO:0031667 response to nutrient levels GO:0032259 methylation GO:0034968 histone lysine methylation GO:0036124 histone H3-K9 trimethylation GO:0042063 gliogenesis GO:0043414 macromolecule methylation GO:0043500 muscle adaptation GO:0045666 positive regulation of neuron differentiation GO:0045685 regulation of glial cell differentiation GO:0045686 negative regulation of glial cell differentiation GO:0048708 astrocyte differentiation GO:0048710 regulation of astrocyte differentiation GO:0048712 negative regulation of astrocyte differentiation GO:0050768 negative regulation of neurogenesis GO:0050769 positive regulation of neurogenesis GO:0051567 histone H3-K9 methylation GO:0051570 regulation of histone H3-K9 methylation GO:0051573 negative regulation of histone H3-K9 methylation GO:0051961 negative regulation of nervous system development GO:0051962 positive regulation of nervous system development GO:0061647 histone H3-K9 modification GO:0070076 histone lysine demethylation GO:0070544 histone H3-K36 demethylation GO:0070988 demethylation GO:1900112 regulation of histone H3-K9 trimethylation GO:1900113 negative regulation of histone H3-K9 trimethylation GO:1902275 regulation of chromatin organization GO:1905268 negative regulation of chromatin organization
Molecular Function	GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors GO:0031625 ubiquitin protein ligase binding GO:0032451 demethylase activity GO:0032452 histone demethylase activity GO:0035064 methylated histone binding GO:0042393 histone binding GO:0044389 ubiquitin-like protein ligase binding GO:0051213 dioxygenase activity GO:0051864 histone demethylase activity (H3-K36 specific)
Cellular Component	GO:0000775 chromosome, centromeric region GO:0000785 chromatin GO:0000792 heterochromatin GO:0005721 pericentric heterochromatin GO:0098687 chromosomal region

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-5693606: DNA Double Strand Break Response R-HSA-5693532: DNA Double-Strand Break Repair R-HSA-73894: DNA Repair R-HSA-3214842: HDMs demethylate histones R-HSA-5693565: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks

Summary
Symbol	KDM4A
Name	lysine demethylase 4A
Aliases	KIAA0677; JHDM3A; TDRD14A; jumonji C domain-containing histone demethylase 3A; tudor domain containing 14A; ......
Location	1p34.2-p34.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM1342903	c.356G>A	p.R119Q	Substitution - Missense	Large_intestine
COSM909895	c.1199G>A	p.R400Q	Substitution - Missense	Endometrium
COSM3386190	c.2914G>T	p.V972F	Substitution - Missense	Pancreas
COSM909896	c.1429G>A	p.E477K	Substitution - Missense	Endometrium
COSM3790058	c.1444G>C	p.A482P	Substitution - Missense	Urinary_tract
COSM3689709	c.653G>A	p.R218Q	Substitution - Missense	Large_intestine
COSM4952685	c.1190A>G	p.K397R	Substitution - Missense	Liver
COSM5992256	c.2300C>A	p.S767*	Substitution - Nonsense	Prostate
COSM4388773	c.2320-7T>C	p.?	Unknown	Pancreas
COSM681261	c.352G>T	p.E118*	Substitution - Nonsense	Lung
COSM3741291	c.662G>T	p.R221L	Substitution - Missense	Liver
COSM4777663	c.389_390insC	p.I131fs*12	Insertion - Frameshift	Prostate
COSM909894	c.955G>A	p.V319M	Substitution - Missense	Endometrium
COSM5906261	c.2569C>T	p.H857Y	Substitution - Missense	Skin
COSM5910189	c.1360C>T	p.P454S	Substitution - Missense	Skin
COSM5505666	c.1183G>A	p.G395R	Substitution - Missense	Biliary_tract
COSM5624070	c.1813C>T	p.R605C	Substitution - Missense	Oesophagus
COSM1627080	c.2363C>T	p.A788V	Substitution - Missense	Liver
COSM325599	c.1903G>T	p.A635S	Substitution - Missense	Lung
COSM4694954	c.2592C>T	p.A864A	Substitution - coding silent	Large_intestine
COSM282118	c.673+7T>C	p.?	Unknown	Large_intestine
COSM909899	c.2138C>T	p.S713L	Substitution - Missense	Endometrium
COSM312112	c.1303G>A	p.A435T	Substitution - Missense	Large_intestine
COSM161882	c.866C>T	p.T289I	Substitution - Missense	Breast
COSM1602444	c.1258C>A	p.L420M	Substitution - Missense	Liver
COSM234843	c.1944T>A	p.P648P	Substitution - coding silent	Skin
COSM3790059	c.1651G>C	p.D551H	Substitution - Missense	Urinary_tract
COSM3790061	c.3100G>A	p.E1034K	Substitution - Missense	Urinary_tract
COSM5922042	c.1555G>A	p.D519N	Substitution - Missense	Skin
COSM5095405	c.2226C>T	p.S742S	Substitution - coding silent	Thymus
COSM4562659	c.937G>A	p.V313M	Substitution - Missense	Skin
COSM4491526	c.381C>T	p.F127F	Substitution - coding silent	Skin
COSM4466945	c.1462C>T	p.L488F	Substitution - Missense	Skin
COSM5719265	c.683C>T	p.P228L	Substitution - Missense	Skin
COSM3689710	c.2614G>A	p.D872N	Substitution - Missense	Large_intestine
COSM4995456	c.613C>T	p.P205S	Substitution - Missense	Upper_aerodigestive_tract
COSM120930	c.8C>T	p.S3F	Substitution - Missense	Upper_aerodigestive_tract
COSM4008298	c.1493G>A	p.R498H	Substitution - Missense	Stomach
COSM5509687	c.2256delC	p.P754fs*18	Deletion - Frameshift	Biliary_tract
COSM3720142	c.2426A>G	p.N809S	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5794490	c.2195C>G	p.T732S	Substitution - Missense	Breast
COSM1211731	c.1873A>G	p.T625A	Substitution - Missense	Stomach
COSM1211731	c.1873A>G	p.T625A	Substitution - Missense	Large_intestine
COSM3944103	c.138+6G>T	p.?	Unknown	Ovary
COSM3805347	c.1318A>C	p.T440P	Substitution - Missense	Breast
COSM312113	c.1602A>T	p.R534R	Substitution - coding silent	Lung
COSM1667511	c.2035C>T	p.Q679*	Substitution - Nonsense	Lung
COSM4768947	c.3025G>A	p.E1009K	Substitution - Missense	Biliary_tract
COSM5381065	c.297G>A	p.K99K	Substitution - coding silent	Skin
COSM1719244	c.1148G>T	p.G383V	Substitution - Missense	Skin
COSM5705464	c.2866C>T	p.P956S	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4408765	c.2593G>A	p.G865S	Substitution - Missense	Oesophagus
COSM5733862	c.2955G>A	p.M985I	Substitution - Missense	Pancreas
COSM1342901	c.4G>A	p.A2T	Substitution - Missense	Large_intestine
COSM4754054	c.2738G>A	p.R913H	Substitution - Missense	Stomach
COSM426322	c.1495C>T	p.L499F	Substitution - Missense	Breast
COSM4943694	c.310G>A	p.D104N	Substitution - Missense	Liver
COSM110112	c.454C>T	p.R152W	Substitution - Missense	Skin
COSM909899	c.2138C>T	p.S713L	Substitution - Missense	Stomach
COSM4951497	c.2375G>C	p.R792T	Substitution - Missense	Liver
COSM1190677	c.2308delG	p.A770fs*2	Deletion - Frameshift	Lung
COSM1627080	c.2363C>T	p.A788V	Substitution - Missense	Liver
COSM4627264	c.2198G>A	p.S733N	Substitution - Missense	Large_intestine
COSM128301	c.1626C>T	p.L542L	Substitution - coding silent	Upper_aerodigestive_tract
COSM909893	c.83G>A	p.S28N	Substitution - Missense	Endometrium
COSM909898	c.1940G>A	p.R647Q	Substitution - Missense	Endometrium
COSM3790060	c.2177A>T	p.Y726F	Substitution - Missense	Urinary_tract
COSM1602446	c.3030T>C	p.L1010L	Substitution - coding silent	Liver
COSM1719244	c.1148G>T	p.G383V	Substitution - Missense	Skin
COSM5941519	c.1163+6C>T	p.?	Unknown	Skin
COSM4238620	c.1508G>T	p.G503V	Substitution - Missense	Large_intestine
COSM426320	c.1043C>T	p.P348L	Substitution - Missense	Breast
COSM4008297	c.1468G>A	p.V490M	Substitution - Missense	Stomach
COSM459171	c.2294G>A	p.R765Q	Substitution - Missense	Cervix
COSM4952685	c.1190A>G	p.K397R	Substitution - Missense	Liver
COSM3944104	c.2559A>T	p.P853P	Substitution - coding silent	Ovary
COSM4877885	c.2807C>T	p.S936F	Substitution - Missense	Prostate
COSM1627079	c.2362G>T	p.A788S	Substitution - Missense	Liver
COSM4143992	c.1445C>A	p.A482E	Substitution - Missense	Thyroid
COSM4008295	c.107C>T	p.S36F	Substitution - Missense	Stomach
COSM3490035	c.1779C>T	p.S593S	Substitution - coding silent	Skin
COSM1172148	c.1684A>T	p.R562W	Substitution - Missense	Oesophagus
COSM1748463	c.247A>G	p.T83A	Substitution - Missense	Urinary_tract
COSM4008299	c.1630G>A	p.V544M	Substitution - Missense	Stomach
COSM5992256	c.2300C>A	p.S767*	Substitution - Nonsense	Prostate
COSM1342904	c.676delT	p.F227fs*16	Deletion - Frameshift	Large_intestine
COSM909901	c.3073C>T	p.R1025C	Substitution - Missense	Endometrium
COSM4694948	c.156G>A	p.E52E	Substitution - coding silent	Large_intestine
COSM1667512	c.3041T>C	p.V1014A	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4515316	c.1036_1037CC>TT	p.P346F	Substitution - Missense	Skin
COSM3490032	c.551C>T	p.S184F	Substitution - Missense	Skin
COSM5053522	c.1198C>T	p.R400*	Substitution - Nonsense	Stomach
COSM909900	c.2474G>A	p.R825H	Substitution - Missense	Endometrium
COSM1602445	c.2728A>G	p.K910E	Substitution - Missense	Liver
COSM5958598	c.1114G>A	p.E372K	Substitution - Missense	Thyroid
COSM1342909	c.3087T>A	p.I1029I	Substitution - coding silent	Large_intestine
COSM4791533	c.759T>C	p.Y253Y	Substitution - coding silent	Liver
COSM4800243	c.2239G>T	p.A747S	Substitution - Missense	Liver
COSM464663	c.606T>C	p.F202F	Substitution - coding silent	Kidney
COSM4491759	c.385C>T	p.P129S	Substitution - Missense	Skin
COSM4500211	c.55C>T	p.P19S	Substitution - Missense	Skin
COSM3741292	c.1213A>C	p.I405L	Substitution - Missense	Liver
COSM4694950	c.680T>C	p.F227S	Substitution - Missense	Large_intestine
COSM426321	c.1276G>A	p.E426K	Substitution - Missense	Breast
COSM681258	c.2843G>C	p.S948T	Substitution - Missense	Lung
COSM3985090	c.3091A>G	p.T1031A	Substitution - Missense	Kidney
COSM3735966	c.1280T>C	p.M427T	Substitution - Missense	Skin
COSM1342906	c.1699G>A	p.A567T	Substitution - Missense	Prostate
COSM265343	c.328C>T	p.R110C	Substitution - Missense	Large_intestine
COSM312112	c.1303G>A	p.A435T	Substitution - Missense	Lung
COSM3805349	c.2182G>C	p.E728Q	Substitution - Missense	Breast
COSM3490031	c.499A>G	p.T167A	Substitution - Missense	Skin
COSM4878625	c.2230C>T	p.R744W	Substitution - Missense	Prostate
COSM4986563	c.2300C>T	p.S767L	Substitution - Missense	Soft_tissue
COSM110112	c.454C>T	p.R152W	Substitution - Missense	Stomach
COSM5781877	c.587G>A	p.S196N	Substitution - Missense	Breast
COSM4694951	c.699C>A	p.S233R	Substitution - Missense	Large_intestine
COSM1602446	c.3030T>C	p.L1010L	Substitution - coding silent	Liver
COSM5943886	c.315-6delA	p.?	Unknown	Skin
COSM2171210	c.1214T>C	p.I405T	Substitution - Missense	Large_intestine
COSM1748463	c.247A>G	p.T83A	Substitution - Missense	Urinary_tract
COSM1321046	c.1283C>T	p.T428M	Substitution - Missense	Ovary
COSM110112	c.454C>T	p.R152W	Substitution - Missense	Skin
COSM1342905	c.962T>C	p.V321A	Substitution - Missense	Large_intestine
COSM5624069	c.1789C>A	p.R597S	Substitution - Missense	Oesophagus
COSM123887	c.1984G>T	p.A662S	Substitution - Missense	Upper_aerodigestive_tract
COSM4754051	c.2419T>G	p.F807V	Substitution - Missense	Stomach
COSM4791533	c.759T>C	p.Y253Y	Substitution - coding silent	Liver
COSM681259	c.1672G>C	p.E558Q	Substitution - Missense	Lung
COSM3805348	c.1386C>G	p.V462V	Substitution - coding silent	Breast
COSM414900	c.3094G>A	p.E1032K	Substitution - Missense	Urinary_tract
COSM3490033	c.1753T>G	p.F585V	Substitution - Missense	Skin
COSM3785296	c.2242+9T>A	p.?	Unknown	Pancreas
COSM5992862	c.2301A>G	p.S767S	Substitution - coding silent	Prostate
COSM5992256	c.2300C>A	p.S767*	Substitution - Nonsense	Prostate
COSM3386189	c.2496C>A	p.F832L	Substitution - Missense	Pancreas
COSM6009256	c.2336C>T	p.S779L	Substitution - Missense	Skin
COSM4008301	c.2821C>T	p.L941F	Substitution - Missense	Stomach
COSM1602444	c.1258C>A	p.L420M	Substitution - Missense	Liver
COSM312113	c.1602A>T	p.R534R	Substitution - coding silent	Soft_tissue
COSM3490034	c.1755T>A	p.F585L	Substitution - Missense	Skin
COSM4143992	c.1445C>A	p.A482E	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM355924	c.2231G>A	p.R744Q	Substitution - Missense	Lung
COSM4165203	c.1951T>A	p.F651I	Substitution - Missense	Kidney
COSM5507987	c.499A>T	p.T167S	Substitution - Missense	Biliary_tract
COSM4694953	c.1475C>T	p.P492L	Substitution - Missense	Large_intestine
COSM5943886	c.315-6delA	p.?	Unknown	Skin
COSM909902	c.3182C>T	p.A1061V	Substitution - Missense	Endometrium
COSM1627079	c.2362G>T	p.A788S	Substitution - Missense	Liver
COSM4951497	c.2375G>C	p.R792T	Substitution - Missense	Liver
COSM4411994	c.806T>C	p.I269T	Substitution - Missense	Oesophagus
COSM224778	c.716G>A	p.R239H	Substitution - Missense	Skin
COSM909901	c.3073C>T	p.R1025C	Substitution - Missense	Endometrium
COSM4995457	c.2737C>A	p.R913S	Substitution - Missense	Upper_aerodigestive_tract
COSM5719265	c.683C>T	p.P228L	Substitution - Missense	Skin
COSM5992862	c.2301A>G	p.S767S	Substitution - coding silent	Prostate
COSM909897	c.1790G>A	p.R597H	Substitution - Missense	Endometrium
COSM5982785	c.1057T>C	p.F353L	Substitution - Missense	Upper_aerodigestive_tract
COSM4970430	c.897C>T	p.Y299Y	Substitution - coding silent	Central_nervous_system
COSM5992862	c.2301A>G	p.S767S	Substitution - coding silent	Prostate
COSM245193	c.2613C>A	p.D871E	Substitution - Missense	Prostate
COSM5786642	c.101T>C	p.I34T	Substitution - Missense	Breast
COSM3966611	c.890T>C	p.I297T	Substitution - Missense	Central_nervous_system
COSM5485699	c.2908G>A	p.G970S	Substitution - Missense	Large_intestine
COSM4008300	c.2312T>C	p.L771P	Substitution - Missense	Stomach
COSM120931	c.337G>A	p.E113K	Substitution - Missense	Upper_aerodigestive_tract
COSM3356591	c.3087T>G	p.I1029M	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4799980	c.2833G>C	p.D945H	Substitution - Missense	Liver
COSM4127675	c.2842-3C>T	p.?	Unknown	Oesophagus
COSM2171221	c.1945C>T	p.P649S	Substitution - Missense	Oesophagus
COSM3805350	c.3035A>G	p.K1012R	Substitution - Missense	Breast
COSM3805346	c.1284G>A	p.T428T	Substitution - coding silent	Breast
COSM5719265	c.683C>T	p.P228L	Substitution - Missense	Skin
COSM1196531	c.1529C>G	p.S510C	Substitution - Missense	Lung
COSM4694949	c.283C>T	p.R95*	Substitution - Nonsense	Large_intestine
COSM4008296	c.666C>T	p.L222L	Substitution - coding silent	Stomach
COSM1732390	c.1885G>C	p.E629Q	Substitution - Missense	Bone
COSM4143992	c.1445C>A	p.A482E	Substitution - Missense	Breast
COSM1342907	c.2484+2T>C	p.?	Unknown	Large_intestine
COSM5504835	c.1207C>G	p.L403V	Substitution - Missense	Biliary_tract
COSM4387345	c.503T>C	p.I168T	Substitution - Missense	Lung
COSM2171230	c.2583C>T	p.A861A	Substitution - coding silent	Large_intestine
COSM5719265	c.683C>T	p.P228L	Substitution - Missense	Skin
COSM5594751	c.2512A>G	p.K838E	Substitution - Missense	Skin
COSM1342908	c.2778C>A	p.T926T	Substitution - coding silent	Large_intestine
COSM4800243	c.2239G>T	p.A747S	Substitution - Missense	Liver
COSM4799980	c.2833G>C	p.D945H	Substitution - Missense	Liver
COSM1342906	c.1699G>A	p.A567T	Substitution - Missense	Large_intestine
COSM3790057	c.1396G>C	p.E466Q	Substitution - Missense	Urinary_tract
COSM4926728	c.749T>C	p.L250P	Substitution - Missense	Liver
COSM4855999	c.2807C>A	p.S936Y	Substitution - Missense	Cervix
COSM5803110	c.1856-2A>G	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM4404432	c.1500C>G	p.V500V	Substitution - coding silent	Skin
COSM5025262	c.2039T>C	p.V680A	Substitution - Missense	Breast
COSM4143992	c.1445C>A	p.A482E	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM464664	c.1935G>C	p.Q645H	Substitution - Missense	Kidney
COSM4143992	c.1445C>A	p.A482E	Substitution - Missense	Biliary_tract
COSM681262	c.259A>G	p.I87V	Substitution - Missense	Lung
COSM4615864	c.1505_1506insTTGTCT	p.S502_G503insCL	Insertion - In frame	Large_intestine
COSM426319	c.383A>G	p.N128S	Substitution - Missense	Breast
COSM5585565	c.767C>T	p.P256L	Substitution - Missense	Skin
COSM4442640	c.322A>G	p.T108A	Substitution - Missense	Large_intestine
COSM1687593	c.2513A>G	p.K838R	Substitution - Missense	Skin
COSM1602445	c.2728A>G	p.K910E	Substitution - Missense	Liver
COSM1178835	c.412G>A	p.G138S	Substitution - Missense	Prostate
COSM1211732	c.2516G>T	p.R839I	Substitution - Missense	Large_intestine
COSM5053521	c.1035G>A	p.L345L	Substitution - coding silent	Stomach
COSM4694952	c.1096_1098delGAG	p.E368delE	Deletion - In frame	Large_intestine
COSM5053520	c.639T>C	p.P213P	Substitution - coding silent	Stomach
COSM3805345	c.1276G>C	p.E426Q	Substitution - Missense	Breast
COSM4486698	c.3090C>T	p.F1030F	Substitution - coding silent	Skin
COSM5448663	c.2202A>G	p.I734M	Substitution - Missense	Large_intestine

> Text Mining based Variations

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PMID	Variation	Cancer	Evidence
28611305	Mutation	Oral Squamous Cell Carcinoma	The purpose of this study was to examine KDM4A as an independent prognostic marker in oral squamous cell carcinoma, using multicenter tissue microarrays. The expression of KDM4A was significantly correlated with lymph node metastasis and TNM stage. KDM4A overexpression was associated with poor overall survival, and it was found to be a statistically significant independent predictor of all-cause mortality.

Summary
Symbol	KDM4A
Name	lysine demethylase 4A
Aliases	KIAA0677; JHDM3A; TDRD14A; jumonji C domain-containing histone demethylase 3A; tudor domain containing 14A; ......
Location	1p34.2-p34.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

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Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
O75164	523	S	Phosphoserine	-	No	None detected

Summary
Symbol	KDM4A
Name	lysine demethylase 4A
Aliases	KIAA0677; JHDM3A; TDRD14A; jumonji C domain-containing histone demethylase 3A; tudor domain containing 14A; ......
Location	1p34.2-p34.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

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Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	5.626	6.108	0.528	0.00018	NS
BRCA	Breast invasive carcinoma	112	1100	5.964	6.24	0.257	1.09e-07	NS
CESC	Cervical and endocervical cancers	3	306	5.613	6.022	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	6.517	5.801	-0.607	1.24e-17	Under
ESCA	Esophageal carcinoma	11	185	5.582	5.79	0.297	0.124	NS
GBM	Glioblastoma multiforme	5	166	5.743	5.917	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	5.702	5.852	0.187	0.0207	NS
KIRC	Kidney renal clear cell carcinoma	72	534	5.821	5.58	-0.174	0.000532	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	5.805	5.642	-0.118	0.19	NS
LAML	Acute Myeloid Leukemia	0	173	NA	6.523	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	5.861	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	4.855	4.94	0.04	0.688	NS
LUAD	Lung adenocarcinoma	59	517	5.939	5.862	-0.053	0.414	NS
LUSC	Lung squamous cell carcinoma	51	501	5.87	6.146	0.359	3.95e-05	NS
OV	Ovarian serous cystadenocarcinoma	0	307	NA	6.558	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	5.698	5.49	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	6.032	5.207	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	5.905	6.044	0.157	0.00437	NS
READ	Rectum adenocarcinoma	10	167	6.074	5.795	-0.19	0.274	NS
SARC	Sarcoma	2	263	5.295	5.706	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	5.725	6.018	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	5.827	5.712	0.019	0.868	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	6.489	NA	NA	NA
THCA	Thyroid carcinoma	59	509	6.032	6.119	0.102	0.0219	NS
THYM	Thymoma	2	120	6.089	6.224	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	5.823	6.294	0.418	1.08e-05	NS

> Cancer Cell Line Encyclopedia (CCLE)

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Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	7.6
Autonomic ganglia	CHP212	7.1
Autonomic ganglia	IMR32	7.4
Autonomic ganglia	KELLY	8.3
Autonomic ganglia	KPNRTBM1	7.1
Autonomic ganglia	KPNSI9S	7.4
Autonomic ganglia	KPNYN	6.9
Autonomic ganglia	MHHNB11	7.8
Autonomic ganglia	NB1	7.3
Autonomic ganglia	NH6	7.1
Autonomic ganglia	SHSY5Y	7.4
Autonomic ganglia	SIMA	7.6
Autonomic ganglia	SKNAS	7.4
Autonomic ganglia	SKNBE2	7.2
Autonomic ganglia	SKNDZ	7.7
Autonomic ganglia	SKNFI	7.4
Autonomic ganglia	SKNSH	7.4
Biliary tract	HUCCT1	7.4
Biliary tract	HUH28	8.5
Biliary tract	SNU1079	7
Biliary tract	SNU1196	7
Biliary tract	SNU245	6.9
Biliary tract	SNU308	6.9
Biliary tract	SNU478	7.1
Bone	143B	7.5
Bone	A673	7.6
Bone	CADOES1	8.1
Bone	CAL78	7.8
Bone	G292CLONEA141B1	7.8
Bone	HOS	7.7
Bone	HS706T	7.4
Bone	HS737T	7.8
Bone	HS819T	7.7
Bone	HS821T	7.3
Bone	HS822T	7.4
Bone	HS863T	7.1
Bone	HS870T	6.9
Bone	HS888T	7.3
Bone	MG63	7.2
Bone	MHHES1	9
Bone	OUMS27	7.7
Bone	RDES	8.5
Bone	SJSA1	7.5
Bone	SKES1	8.2
Bone	SKNMC	8.1
Bone	SW1353	7.5
Bone	T173	7.6
Bone	TC71	8.1
Bone	U2OS	8.1
Breast	AU565	7.1
Breast	BT20	7.5
Breast	BT474	8.2
Breast	BT483	7.8
Breast	BT549	7.5
Breast	CAL120	7.8
Breast	CAL148	8.1
Breast	CAL51	8.2
Breast	CAL851	7.2
Breast	CAMA1	7.1
Breast	DU4475	7.1
Breast	EFM192A	6.9
Breast	EFM19	8.4
Breast	EVSAT	7.2
Breast	HCC1143	7.2
Breast	HCC1187	8.3
Breast	HCC1395	8
Breast	HCC1419	7.6
Breast	HCC1428	7.5
Breast	HCC1500	7.5
Breast	HCC1569	8.1
Breast	HCC1599	7.2
Breast	HCC1806	7.5
Breast	HCC1937	7.3
Breast	HCC1954	7.3
Breast	HCC202	7.7
Breast	HCC2157	8
Breast	HCC2218	7.3
Breast	HCC38	8.2
Breast	HCC70	7.9
Breast	HDQP1	7.4
Breast	HMC18	8.2
Breast	HS274T	7.7
Breast	HS281T	7.4
Breast	HS343T	7.1
Breast	HS578T	7.3
Breast	HS606T	7.6
Breast	HS739T	7.7
Breast	HS742T	7.2
Breast	JIMT1	8.3
Breast	KPL1	7.7
Breast	MCF7	8
Breast	MDAMB134VI	7.1
Breast	MDAMB157	7.3
Breast	MDAMB175VII	7
Breast	MDAMB231	7.3
Breast	MDAMB361	7.4
Breast	MDAMB415	7.7
Breast	MDAMB436	7.6
Breast	MDAMB453	8.2
Breast	MDAMB468	7.9
Breast	SKBR3	7.7
Breast	T47D	7.2
Breast	UACC812	7.7
Breast	UACC893	7
Breast	YMB1	7
Breast	ZR751	6.6
Breast	ZR7530	7.8
Central nervous system	1321N1	8.2
Central nervous system	42MGBA	8.4
Central nervous system	8MGBA	8.3
Central nervous system	A172	7.2
Central nervous system	AM38	7.2
Central nervous system	BECKER	7.3
Central nervous system	CAS1	7.2
Central nervous system	CCFSTTG1	6.9
Central nervous system	D283MED	7.8
Central nervous system	D341MED	8.4
Central nervous system	DAOY	7
Central nervous system	DBTRG05MG	7.5
Central nervous system	DKMG	7.3
Central nervous system	GAMG	7.4
Central nervous system	GB1	7.3
Central nervous system	GI1	7.9
Central nervous system	GMS10	7.8
Central nervous system	GOS3	7.8
Central nervous system	H4	8
Central nervous system	HS683	7.3
Central nervous system	KALS1	7.7
Central nervous system	KG1C	7.6
Central nervous system	KNS42	7.4
Central nervous system	KNS60	7.4
Central nervous system	KNS81	7.3
Central nervous system	KS1	6.9
Central nervous system	LN18	7.9
Central nervous system	LN229	7.5
Central nervous system	M059K	7.3
Central nervous system	MOGGCCM	7.4
Central nervous system	MOGGUVW	7.8
Central nervous system	NMCG1	6.8
Central nervous system	ONS76	7.1
Central nervous system	SF126	7.8
Central nervous system	SF295	7.2
Central nervous system	SNB19	7.7
Central nervous system	SNU1105	7.5
Central nervous system	SNU201	7.2
Central nervous system	SNU466	7.7
Central nervous system	SNU489	7.7
Central nervous system	SNU626	7.1
Central nervous system	SNU738	7.7
Central nervous system	SW1088	7.5
Central nervous system	SW1783	7.3
Central nervous system	T98G	8.1
Central nervous system	TM31	7.4
Central nervous system	U118MG	6.9
Central nervous system	U138MG	7.4
Central nervous system	U251MG	7.5
Central nervous system	U87MG	7
Central nervous system	YH13	7.3
Central nervous system	YKG1	7.9
Endometrium	AN3CA	8.1
Endometrium	COLO684	7.4
Endometrium	EFE184	7.5
Endometrium	EN	7.7
Endometrium	ESS1	7.5
Endometrium	HEC108	7.8
Endometrium	HEC151	7.6
Endometrium	HEC1A	7.6
Endometrium	HEC1B	7.6
Endometrium	HEC251	7.3
Endometrium	HEC265	7.2
Endometrium	HEC50B	7.5
Endometrium	HEC59	7.5
Endometrium	HEC6	7.8
Endometrium	ISHIKAWAHERAKLIO02ER	7.8
Endometrium	JHUEM1	8.3
Endometrium	JHUEM2	8.5
Endometrium	JHUEM3	7.5
Endometrium	KLE	7.6
Endometrium	MFE280	8.1
Endometrium	MFE296	8.3
Endometrium	MFE319	7.9
Endometrium	RL952	7.7
Endometrium	SNGM	8.2
Endometrium	SNU1077	7.3
Endometrium	SNU685	7.2
Endometrium	TEN	7.6
Haematopoietic and lymphoid	697	7.8
Haematopoietic and lymphoid	A3KAW	7.7
Haematopoietic and lymphoid	A4FUK	7.6
Haematopoietic and lymphoid	ALLSIL	7.5
Haematopoietic and lymphoid	AML193	7.9
Haematopoietic and lymphoid	AMO1	7.7
Haematopoietic and lymphoid	BCP1	8.4
Haematopoietic and lymphoid	BDCM	8.1
Haematopoietic and lymphoid	BL41	7.4
Haematopoietic and lymphoid	BL70	7.7
Haematopoietic and lymphoid	BV173	8.1
Haematopoietic and lymphoid	CA46	8.6
Haematopoietic and lymphoid	CI1	7.2
Haematopoietic and lymphoid	CMK115	7.6
Haematopoietic and lymphoid	CMK86	7.6
Haematopoietic and lymphoid	CMK	8.1
Haematopoietic and lymphoid	CMLT1	7.9
Haematopoietic and lymphoid	COLO775	6.7
Haematopoietic and lymphoid	DAUDI	7.5
Haematopoietic and lymphoid	DB	7.4
Haematopoietic and lymphoid	DEL	7.6
Haematopoietic and lymphoid	DND41	8.1
Haematopoietic and lymphoid	DOHH2	7.6
Haematopoietic and lymphoid	EB1	7.9
Haematopoietic and lymphoid	EB2	7.6
Haematopoietic and lymphoid	EHEB	7.3
Haematopoietic and lymphoid	EJM	7.8
Haematopoietic and lymphoid	EM2	7.5
Haematopoietic and lymphoid	EOL1	8
Haematopoietic and lymphoid	F36P	8
Haematopoietic and lymphoid	GA10	7.3
Haematopoietic and lymphoid	GDM1	7.6
Haematopoietic and lymphoid	GRANTA519	7.6
Haematopoietic and lymphoid	HDLM2	7.1
Haematopoietic and lymphoid	HDMYZ	7.9
Haematopoietic and lymphoid	HEL9217	8.4
Haematopoietic and lymphoid	HEL	8.6
Haematopoietic and lymphoid	HH	7.8
Haematopoietic and lymphoid	HL60	8.2
Haematopoietic and lymphoid	HPBALL	7.9
Haematopoietic and lymphoid	HS604T	7.5
Haematopoietic and lymphoid	HS611T	7.5
Haematopoietic and lymphoid	HS616T	7.6
Haematopoietic and lymphoid	HS751T	7.1
Haematopoietic and lymphoid	HT	7.5
Haematopoietic and lymphoid	HTK	7.6
Haematopoietic and lymphoid	HUNS1	7.1
Haematopoietic and lymphoid	HUT102	7.6
Haematopoietic and lymphoid	HUT78	7.9
Haematopoietic and lymphoid	JEKO1	7.1
Haematopoietic and lymphoid	JK1	7.5
Haematopoietic and lymphoid	JM1	7.1
Haematopoietic and lymphoid	JURKAT	7.7
Haematopoietic and lymphoid	JURLMK1	8
Haematopoietic and lymphoid	JVM2	7.6
Haematopoietic and lymphoid	JVM3	7.8
Haematopoietic and lymphoid	K562	8.1
Haematopoietic and lymphoid	KARPAS299	8
Haematopoietic and lymphoid	KARPAS422	7.8
Haematopoietic and lymphoid	KARPAS620	7.1
Haematopoietic and lymphoid	KASUMI1	7.2
Haematopoietic and lymphoid	KASUMI2	7.5
Haematopoietic and lymphoid	KASUMI6	7.6
Haematopoietic and lymphoid	KCL22	8.2
Haematopoietic and lymphoid	KE37	7.9
Haematopoietic and lymphoid	KE97	7.4
Haematopoietic and lymphoid	KG1	7.8
Haematopoietic and lymphoid	KHM1B	7
Haematopoietic and lymphoid	KIJK	7.1
Haematopoietic and lymphoid	KMH2	8
Haematopoietic and lymphoid	KMM1	6.7
Haematopoietic and lymphoid	KMS11	7.3
Haematopoietic and lymphoid	KMS12BM	7.2
Haematopoietic and lymphoid	KMS18	7.6
Haematopoietic and lymphoid	KMS20	6.9
Haematopoietic and lymphoid	KMS21BM	7.2
Haematopoietic and lymphoid	KMS26	8
Haematopoietic and lymphoid	KMS27	7.9
Haematopoietic and lymphoid	KMS28BM	7.6
Haematopoietic and lymphoid	KMS34	7.8
Haematopoietic and lymphoid	KO52	8.5
Haematopoietic and lymphoid	KOPN8	7.8
Haematopoietic and lymphoid	KU812	8
Haematopoietic and lymphoid	KYO1	7.3
Haematopoietic and lymphoid	L1236	7.8
Haematopoietic and lymphoid	L363	8
Haematopoietic and lymphoid	L428	7.4
Haematopoietic and lymphoid	L540	7.7
Haematopoietic and lymphoid	LAMA84	7.5
Haematopoietic and lymphoid	LOUCY	8.2
Haematopoietic and lymphoid	LP1	7.9
Haematopoietic and lymphoid	M07E	8.2
Haematopoietic and lymphoid	MC116	7.4
Haematopoietic and lymphoid	ME1	7.7
Haematopoietic and lymphoid	MEC1	7.9
Haematopoietic and lymphoid	MEC2	7.6
Haematopoietic and lymphoid	MEG01	8
Haematopoietic and lymphoid	MHHCALL2	7.4
Haematopoietic and lymphoid	MHHCALL3	7.6
Haematopoietic and lymphoid	MHHCALL4	7.8
Haematopoietic and lymphoid	MINO	7.4
Haematopoietic and lymphoid	MJ	7.6
Haematopoietic and lymphoid	MM1S	7.7
Haematopoietic and lymphoid	MOLM13	7.8
Haematopoietic and lymphoid	MOLM16	8.4
Haematopoietic and lymphoid	MOLM6	7.7
Haematopoietic and lymphoid	MOLP2	7.2
Haematopoietic and lymphoid	MOLP8	8.1
Haematopoietic and lymphoid	MOLT13	7.6
Haematopoietic and lymphoid	MOLT16	8.3
Haematopoietic and lymphoid	MOLT4	7.7
Haematopoietic and lymphoid	MONOMAC1	8.3
Haematopoietic and lymphoid	MONOMAC6	8.5
Haematopoietic and lymphoid	MOTN1	7.7
Haematopoietic and lymphoid	MUTZ5	8.1
Haematopoietic and lymphoid	MV411	8.1
Haematopoietic and lymphoid	NALM19	7.9
Haematopoietic and lymphoid	NALM1	8
Haematopoietic and lymphoid	NALM6	8.1
Haematopoietic and lymphoid	NAMALWA	7.5
Haematopoietic and lymphoid	NB4	7.5
Haematopoietic and lymphoid	NCIH929	7.3
Haematopoietic and lymphoid	NCO2	7.5
Haematopoietic and lymphoid	NOMO1	8
Haematopoietic and lymphoid	NUDHL1	8.2
Haematopoietic and lymphoid	NUDUL1	8.1
Haematopoietic and lymphoid	OCIAML2	7.8
Haematopoietic and lymphoid	OCIAML3	8.4
Haematopoietic and lymphoid	OCIAML5	7.6
Haematopoietic and lymphoid	OCILY10	7.8
Haematopoietic and lymphoid	OCILY19	7.3
Haematopoietic and lymphoid	OCILY3	6.4
Haematopoietic and lymphoid	OCIM1	8.4
Haematopoietic and lymphoid	OPM2	7.6
Haematopoietic and lymphoid	P12ICHIKAWA	7.9
Haematopoietic and lymphoid	P31FUJ	8.1
Haematopoietic and lymphoid	P3HR1	7.9
Haematopoietic and lymphoid	PCM6	8.4
Haematopoietic and lymphoid	PEER	8.1
Haematopoietic and lymphoid	PF382	8
Haematopoietic and lymphoid	PFEIFFER	7.7
Haematopoietic and lymphoid	PL21	8.2
Haematopoietic and lymphoid	RAJI	7.6
Haematopoietic and lymphoid	RCHACV	8.1
Haematopoietic and lymphoid	REC1	7.9
Haematopoietic and lymphoid	REH	8
Haematopoietic and lymphoid	RI1	7.9
Haematopoietic and lymphoid	RL	7.7
Haematopoietic and lymphoid	RPMI8226	7.6
Haematopoietic and lymphoid	RPMI8402	8.2
Haematopoietic and lymphoid	RS411	7.8
Haematopoietic and lymphoid	SEM	8.1
Haematopoietic and lymphoid	SET2	7.9
Haematopoietic and lymphoid	SIGM5	7.4
Haematopoietic and lymphoid	SKM1	7.3
Haematopoietic and lymphoid	SKMM2	7.8
Haematopoietic and lymphoid	SR786	7.9
Haematopoietic and lymphoid	ST486	7.6
Haematopoietic and lymphoid	SUDHL10	8.1
Haematopoietic and lymphoid	SUDHL1	7.9
Haematopoietic and lymphoid	SUDHL4	8
Haematopoietic and lymphoid	SUDHL5	7.5
Haematopoietic and lymphoid	SUDHL6	7.7
Haematopoietic and lymphoid	SUDHL8	8.1
Haematopoietic and lymphoid	SUPB15	8.4
Haematopoietic and lymphoid	SUPHD1	7.1
Haematopoietic and lymphoid	SUPM2	7.6
Haematopoietic and lymphoid	SUPT11	8.4
Haematopoietic and lymphoid	SUPT1	7.9
Haematopoietic and lymphoid	TALL1	7.4
Haematopoietic and lymphoid	TF1	9.1
Haematopoietic and lymphoid	THP1	10.1
Haematopoietic and lymphoid	TO175T	7.6
Haematopoietic and lymphoid	TOLEDO	7.7
Haematopoietic and lymphoid	U266B1	6.9
Haematopoietic and lymphoid	U937	8.3
Haematopoietic and lymphoid	UT7	8
Haematopoietic and lymphoid	WSUDLCL2	8.4
Kidney	769P	7.5
Kidney	786O	7.6
Kidney	A498	7.7
Kidney	A704	7.3
Kidney	ACHN	7
Kidney	BFTC909	7
Kidney	CAKI1	7.7
Kidney	CAKI2	6.8
Kidney	CAL54	7.4
Kidney	KMRC1	7.2
Kidney	KMRC20	7.2
Kidney	KMRC2	7.7
Kidney	KMRC3	6.8
Kidney	OSRC2	7.2
Kidney	RCC10RGB	6.9
Kidney	SNU1272	7.1
Kidney	SNU349	7
Kidney	TUHR10TKB	7.4
Kidney	TUHR14TKB	7.9
Kidney	TUHR4TKB	7.7
Kidney	VMRCRCW	8
Kidney	VMRCRCZ	7.8
Large intestine	C2BBE1	6.7
Large intestine	CCK81	8
Large intestine	CL11	7.6
Large intestine	CL14	7.3
Large intestine	CL34	7.8
Large intestine	CL40	7.5
Large intestine	COLO205	7.3
Large intestine	COLO320	7.4
Large intestine	COLO678	7.7
Large intestine	CW2	8
Large intestine	DLD1	7.9
Large intestine	GP2D	7.7
Large intestine	HCC56	7.8
Large intestine	HCT116	7.6
Large intestine	HCT15	7.6
Large intestine	HS675T	7.2
Large intestine	HS698T	7.2
Large intestine	HT115	7.5
Large intestine	HT29	7.8
Large intestine	HT55	7.8
Large intestine	KM12	7.8
Large intestine	LOVO	7.6
Large intestine	LS1034	7.6
Large intestine	LS123	7.1
Large intestine	LS180	8.1
Large intestine	LS411N	8.3
Large intestine	LS513	6.8
Large intestine	MDST8	7.3
Large intestine	NCIH508	7.7
Large intestine	NCIH716	7.8
Large intestine	NCIH747	6.9
Large intestine	OUMS23	8.1
Large intestine	RCM1	6.8
Large intestine	RKO	6.6
Large intestine	SKCO1	7.5
Large intestine	SNU1040	7.5
Large intestine	SNU1197	7.3
Large intestine	SNU175	7.7
Large intestine	SNU283	7.2
Large intestine	SNU407	8
Large intestine	SNU503	8.4
Large intestine	SNU61	7.3
Large intestine	SNU81	8
Large intestine	SNUC1	7.4
Large intestine	SNUC2A	8.1
Large intestine	SNUC4	7.8
Large intestine	SNUC5	7.7
Large intestine	SW1116	7.5
Large intestine	SW1417	7.3
Large intestine	SW1463	7.6
Large intestine	SW403	7.5
Large intestine	SW480	7
Large intestine	SW48	8.5
Large intestine	SW620	7.4
Large intestine	SW837	6.9
Large intestine	SW948	7.5
Large intestine	T84	7.3
Liver	ALEXANDERCELLS	7
Liver	C3A	7.5
Liver	HEP3B217	7.6
Liver	HEPG2	7.1
Liver	HLE	6.8
Liver	HLF	7.2
Liver	HUH1	8
Liver	HUH6	7.3
Liver	HUH7	7.3
Liver	JHH1	8
Liver	JHH2	7.6
Liver	JHH4	7.5
Liver	JHH5	8
Liver	JHH6	6.8
Liver	JHH7	7.3
Liver	LI7	7.1
Liver	PLCPRF5	7.1
Liver	SKHEP1	7.3
Liver	SNU182	7.4
Liver	SNU387	6.8
Liver	SNU398	7.5
Liver	SNU423	6.7
Liver	SNU449	6.9
Liver	SNU475	7.4
Liver	SNU761	6.7
Liver	SNU878	7.2
Liver	SNU886	7.5
Lung	A549	7.5
Lung	ABC1	7.5
Lung	BEN	7.4
Lung	CAL12T	7.2
Lung	CALU1	7.1
Lung	CALU3	7.3
Lung	CALU6	7.3
Lung	CHAGOK1	7.8
Lung	COLO668	8.1
Lung	COLO699	7.8
Lung	CORL105	6.7
Lung	CORL23	7.2
Lung	CORL24	8.8
Lung	CORL279	7.6
Lung	CORL311	8.2
Lung	CORL47	7.6
Lung	CORL51	8.1
Lung	CORL88	7.5
Lung	CORL95	7.2
Lung	CPCN	7.9
Lung	DMS114	8.9
Lung	DMS153	8.2
Lung	DMS273	7.8
Lung	DMS454	7.8
Lung	DMS53	8.4
Lung	DMS79	8.5
Lung	DV90	7.7
Lung	EBC1	7.4
Lung	EPLC272H	7.7
Lung	HARA	7.1
Lung	HCC1171	6.9
Lung	HCC1195	8
Lung	HCC15	7.6
Lung	HCC2279	7.2
Lung	HCC2935	6.8
Lung	HCC33	8
Lung	HCC366	7.2
Lung	HCC4006	6.6
Lung	HCC44	7.2
Lung	HCC78	7.1
Lung	HCC827	7.9
Lung	HCC95	6.6
Lung	HLC1	8.3
Lung	HLFA	7.6
Lung	HS229T	7.1
Lung	HS618T	7
Lung	IALM	8.1
Lung	KNS62	7.3
Lung	LC1F	7.1
Lung	LC1SQSF	7.2
Lung	LCLC103H	7.6
Lung	LCLC97TM1	7.4
Lung	LK2	7.7
Lung	LOUNH91	8
Lung	LU65	7.3
Lung	LU99	7.5
Lung	LUDLU1	6.5
Lung	LXF289	7.2
Lung	MORCPR	7.5
Lung	NCIH1048	8
Lung	NCIH1092	7.7
Lung	NCIH1105	8.3
Lung	NCIH1155	8
Lung	NCIH1184	7.6
Lung	NCIH1299	7.6
Lung	NCIH1339	6.9
Lung	NCIH1341	8.1
Lung	NCIH1355	7.1
Lung	NCIH1373	7.3
Lung	NCIH1385	6.9
Lung	NCIH1395	6.9
Lung	NCIH1435	7.1
Lung	NCIH1436	7.7
Lung	NCIH1437	6.6
Lung	NCIH146	7.3
Lung	NCIH1563	8
Lung	NCIH1568	7.4
Lung	NCIH1573	8.7
Lung	NCIH1581	8.1
Lung	NCIH1618	7.9
Lung	NCIH1623	7.7
Lung	NCIH1648	7.1
Lung	NCIH1650	7.3
Lung	NCIH1651	6.7
Lung	NCIH1666	7.4
Lung	NCIH1693	7.5
Lung	NCIH1694	8.3
Lung	NCIH1703	8.3
Lung	NCIH1734	6.9
Lung	NCIH1755	7.6
Lung	NCIH1781	7.4
Lung	NCIH1792	6.8
Lung	NCIH1793	7.6
Lung	NCIH1836	8.2
Lung	NCIH1838	6.7
Lung	NCIH1869	7.4
Lung	NCIH1876	8.6
Lung	NCIH1915	6.5
Lung	NCIH1930	8
Lung	NCIH1944	6.6
Lung	NCIH1963	7.8
Lung	NCIH196	7.7
Lung	NCIH1975	7.5
Lung	NCIH2009	7.4
Lung	NCIH2023	7.4
Lung	NCIH2029	9
Lung	NCIH2030	7.3
Lung	NCIH2066	7.4
Lung	NCIH2081	8.4
Lung	NCIH2085	7.5
Lung	NCIH2087	7.6
Lung	NCIH209	8.7
Lung	NCIH2106	6.8
Lung	NCIH2110	6.6
Lung	NCIH211	8.1
Lung	NCIH2122	7.6
Lung	NCIH2126	8
Lung	NCIH2141	7.7
Lung	NCIH2170	7
Lung	NCIH2171	8.3
Lung	NCIH2172	6.9
Lung	NCIH2196	7.6
Lung	NCIH2227	7.6
Lung	NCIH2228	6.4
Lung	NCIH226	7.4
Lung	NCIH2286	8
Lung	NCIH2291	7.4
Lung	NCIH2342	7.7
Lung	NCIH2347	6.9
Lung	NCIH23	7.9
Lung	NCIH2405	7.4
Lung	NCIH2444	7.5
Lung	NCIH292	7.5
Lung	NCIH322	6.9
Lung	NCIH3255	7
Lung	NCIH358	7.2
Lung	NCIH441	7.7
Lung	NCIH446	7.9
Lung	NCIH460	6.5
Lung	NCIH510	9.3
Lung	NCIH520	9.3
Lung	NCIH522	8.7
Lung	NCIH524	7.5
Lung	NCIH526	9.7
Lung	NCIH596	7.4
Lung	NCIH647	8
Lung	NCIH650	7.5
Lung	NCIH661	7.2
Lung	NCIH69	7.1
Lung	NCIH727	7.5
Lung	NCIH810	7.8
Lung	NCIH82	7.8
Lung	NCIH838	6.5
Lung	NCIH841	8.1
Lung	NCIH854	7.6
Lung	NCIH889	8.1
Lung	PC14	8.4
Lung	RERFLCAD1	7.6
Lung	RERFLCAD2	7.2
Lung	RERFLCAI	6.9
Lung	RERFLCKJ	7.3
Lung	RERFLCMS	7.4
Lung	RERFLCSQ1	7.6
Lung	SBC5	8.8
Lung	SCLC21H	7.4
Lung	SHP77	7.6
Lung	SKLU1	7.5
Lung	SKMES1	7.3
Lung	SQ1	7
Lung	SW1271	7.2
Lung	SW1573	7.8
Lung	SW900	7.3
Lung	VMRCLCD	7.1
Lung	VMRCLCP	7.6
Oesophagus	COLO680N	7.2
Oesophagus	ECGI10	6.7
Oesophagus	KYSE140	7.5
Oesophagus	KYSE150	8
Oesophagus	KYSE180	7.5
Oesophagus	KYSE270	8
Oesophagus	KYSE30	8.2
Oesophagus	KYSE410	7.4
Oesophagus	KYSE450	8
Oesophagus	KYSE510	7.4
Oesophagus	KYSE520	7.7
Oesophagus	KYSE70	8.8
Oesophagus	OE19	7.4
Oesophagus	OE33	6.3
Oesophagus	TE10	7.4
Oesophagus	TE11	7.5
Oesophagus	TE14	7.5
Oesophagus	TE15	7.1
Oesophagus	TE1	8
Oesophagus	TE4	7.3
Oesophagus	TE5	7.3
Oesophagus	TE6	7.1
Oesophagus	TE8	7.3
Oesophagus	TE9	7.4
Oesophagus	TT	8.1
Ovary	59M	7.2
Ovary	A2780	8.4
Ovary	CAOV3	8.5
Ovary	CAOV4	8
Ovary	COLO704	8.2
Ovary	COV318	8.3
Ovary	COV362	7.1
Ovary	COV434	7.5
Ovary	COV504	7.1
Ovary	COV644	7.4
Ovary	EFO21	7.8
Ovary	EFO27	7.9
Ovary	ES2	7.7
Ovary	FUOV1	7.5
Ovary	HEYA8	7.9
Ovary	HS571T	7.6
Ovary	IGROV1	8.5
Ovary	JHOC5	7.4
Ovary	JHOM1	7.9
Ovary	JHOM2B	7.6
Ovary	JHOS2	7.5
Ovary	JHOS4	7.8
Ovary	KURAMOCHI	8.5
Ovary	MCAS	7.6
Ovary	NIHOVCAR3	7.4
Ovary	OAW28	7.4
Ovary	OAW42	7.5
Ovary	OC314	7.6
Ovary	OC316	7.3
Ovary	ONCODG1	7.5
Ovary	OV56	7.2
Ovary	OV7	7.4
Ovary	OV90	7.8
Ovary	OVCAR4	7.9
Ovary	OVCAR8	6.6
Ovary	OVISE	8
Ovary	OVK18	8.4
Ovary	OVKATE	7.9
Ovary	OVMANA	7.5
Ovary	OVSAHO	8.4
Ovary	OVTOKO	7
Ovary	RMGI	7.6
Ovary	RMUGS	7.9
Ovary	SKOV3	7
Ovary	SNU119	7.8
Ovary	SNU840	7.9
Ovary	SNU8	7.5
Ovary	TOV112D	7.3
Ovary	TOV21G	7.7
Ovary	TYKNU	8.2
Pancreas	ASPC1	7.6
Pancreas	BXPC3	7.6
Pancreas	CAPAN1	7.3
Pancreas	CAPAN2	7.5
Pancreas	CFPAC1	7.1
Pancreas	DANG	6.8
Pancreas	HPAC	8.2
Pancreas	HPAFII	7.1
Pancreas	HS766T	8.1
Pancreas	HUPT3	7.5
Pancreas	HUPT4	7.2
Pancreas	KCIMOH1	8.3
Pancreas	KLM1	7.5
Pancreas	KP2	7.7
Pancreas	KP3	7.8
Pancreas	KP4	8.2
Pancreas	L33	7.3
Pancreas	MIAPACA2	8.5
Pancreas	PANC0203	7.3
Pancreas	PANC0213	7.8
Pancreas	PANC0327	7.3
Pancreas	PANC0403	7.3
Pancreas	PANC0504	7.5
Pancreas	PANC0813	6.5
Pancreas	PANC1005	7.1
Pancreas	PANC1	7.2
Pancreas	PATU8902	7.2
Pancreas	PATU8988S	7.4
Pancreas	PATU8988T	7
Pancreas	PK1	7.3
Pancreas	PK45H	7.2
Pancreas	PK59	8
Pancreas	PL45	6.8
Pancreas	PSN1	7.4
Pancreas	QGP1	9.6
Pancreas	SNU213	7.4
Pancreas	SNU324	7.7
Pancreas	SNU410	7.3
Pancreas	SU8686	7.3
Pancreas	SUIT2	6.9
Pancreas	SW1990	6.8
Pancreas	T3M4	6.8
Pancreas	TCCPAN2	6.9
Pancreas	YAPC	6.8
Pleura	ACCMESO1	6.9
Pleura	DM3	7.1
Pleura	ISTMES1	7.5
Pleura	ISTMES2	7.7
Pleura	JL1	8.2
Pleura	MPP89	7.5
Pleura	MSTO211H	7.8
Pleura	NCIH2052	7.9
Pleura	NCIH2452	8
Pleura	NCIH28	7.9
Prostate	22RV1	7.5
Prostate	DU145	7
Prostate	LNCAPCLONEFGC	8.2
Prostate	MDAPCA2B	7.8
Prostate	NCIH660	8.4
Prostate	PC3	7.1
Prostate	VCAP	7.5
Salivary gland	A253	6.7
Salivary gland	YD15	7.2
Skin	A101D	7.6
Skin	A2058	6.9
Skin	A375	7.3
Skin	C32	8.2
Skin	CHL1	8.4
Skin	CJM	7.7
Skin	COLO679	7.5
Skin	COLO741	7.7
Skin	COLO783	7.5
Skin	COLO792	6.9
Skin	COLO800	7.8
Skin	COLO818	7.4
Skin	COLO829	7.9
Skin	COLO849	7.2
Skin	G361	7
Skin	GRM	7.8
Skin	HMCB	8.5
Skin	HS294T	7.5
Skin	HS600T	7.4
Skin	HS688AT	7.6
Skin	HS695T	7.2
Skin	HS839T	7.2
Skin	HS852T	7.4
Skin	HS895T	6.9
Skin	HS934T	7.3
Skin	HS936T	7
Skin	HS939T	7.1
Skin	HS940T	7.5
Skin	HS944T	7.3
Skin	HT144	7.3
Skin	IGR1	7.5
Skin	IGR37	7.1
Skin	IGR39	7.2
Skin	IPC298	7.5
Skin	K029AX	7.8
Skin	LOXIMVI	7.6
Skin	MALME3M	7.1
Skin	MDAMB435S	6.9
Skin	MELHO	7.6
Skin	MELJUSO	7.6
Skin	MEWO	7
Skin	RPMI7951	7.6
Skin	RVH421	7.3
Skin	SH4	7.3
Skin	SKMEL1	7.3
Skin	SKMEL24	7.8
Skin	SKMEL28	7.5
Skin	SKMEL2	7.2
Skin	SKMEL30	7.7
Skin	SKMEL31	7.8
Skin	SKMEL3	7.5
Skin	SKMEL5	7
Skin	UACC257	7.2
Skin	UACC62	7.5
Skin	WM115	7.9
Skin	WM1799	7.1
Skin	WM2664	7.2
Skin	WM793	7.1
Skin	WM88	7.2
Skin	WM983B	7.6
Small intestine	HUTU80	8.2
Soft tissue	A204	7.6
Soft tissue	G401	7.8
Soft tissue	G402	8
Soft tissue	GCT	7.2
Soft tissue	HS729	7.8
Soft tissue	HT1080	7.7
Soft tissue	KYM1	7.6
Soft tissue	MESSA	7.8
Soft tissue	RD	7.8
Soft tissue	RH30	7.5
Soft tissue	RH41	7.9
Soft tissue	RKN	7.9
Soft tissue	S117	7.5
Soft tissue	SJRH30	8
Soft tissue	SKLMS1	7.6
Soft tissue	SKUT1	8.4
Soft tissue	TE125T	7.3
Soft tissue	TE159T	7.3
Soft tissue	TE441T	8
Soft tissue	TE617T	7.8
Stomach	2313287	8.1
Stomach	AGS	8
Stomach	AZ521	7.5
Stomach	ECC10	7.3
Stomach	ECC12	8
Stomach	FU97	7.1
Stomach	GCIY	7.6
Stomach	GSS	7.5
Stomach	GSU	7.8
Stomach	HGC27	7.8
Stomach	HS746T	7.4
Stomach	HUG1N	7.5
Stomach	IM95	7.7
Stomach	KATOIII	7.3
Stomach	KE39	7.8
Stomach	LMSU	7.6
Stomach	MKN1	7.5
Stomach	MKN45	7.9
Stomach	MKN74	8.1
Stomach	MKN7	7.3
Stomach	NCCSTCK140	7.5
Stomach	NCIN87	7.3
Stomach	NUGC2	7.7
Stomach	NUGC3	7.3
Stomach	NUGC4	7.6
Stomach	OCUM1	7.4
Stomach	RERFGC1B	7.7
Stomach	SH10TC	7.2
Stomach	SNU16	8.1
Stomach	SNU1	8.3
Stomach	SNU216	8.2
Stomach	SNU520	8.4
Stomach	SNU5	7.6
Stomach	SNU601	7.4
Stomach	SNU620	7.3
Stomach	SNU668	6.9
Stomach	SNU719	7.4
Stomach	TGBC11TKB	7.9
Thyroid	8305C	7.3
Thyroid	8505C	7
Thyroid	BCPAP	8.4
Thyroid	BHT101	7.9
Thyroid	CAL62	7.2
Thyroid	CGTHW1	7.7
Thyroid	FTC133	7.2
Thyroid	FTC238	6.7
Thyroid	ML1	7.5
Thyroid	SW579	7.9
Thyroid	TT2609C02	7.1
Thyroid	TT	7.8
Upper aerodigestive tract	BHY	7.2
Upper aerodigestive tract	BICR16	7.7
Upper aerodigestive tract	BICR18	7.5
Upper aerodigestive tract	BICR22	7.6
Upper aerodigestive tract	BICR31	6.9
Upper aerodigestive tract	BICR56	7.6
Upper aerodigestive tract	BICR6	7.4
Upper aerodigestive tract	CAL27	7.2
Upper aerodigestive tract	CAL33	7.2
Upper aerodigestive tract	DETROIT562	6.8
Upper aerodigestive tract	FADU	8.1
Upper aerodigestive tract	HS840T	7.1
Upper aerodigestive tract	HSC2	7.6
Upper aerodigestive tract	HSC3	7.2
Upper aerodigestive tract	HSC4	8.6
Upper aerodigestive tract	PECAPJ15	7
Upper aerodigestive tract	PECAPJ34CLONEC12	7.4
Upper aerodigestive tract	PECAPJ41CLONED2	7.5
Upper aerodigestive tract	PECAPJ49	7.6
Upper aerodigestive tract	SCC15	7.3
Upper aerodigestive tract	SCC25	7.3
Upper aerodigestive tract	SCC4	7.3
Upper aerodigestive tract	SCC9	7.7
Upper aerodigestive tract	SNU1076	8.2
Upper aerodigestive tract	SNU1214	7.7
Upper aerodigestive tract	SNU46	7.2
Upper aerodigestive tract	SNU899	7
Upper aerodigestive tract	YD10B	7.9
Upper aerodigestive tract	YD38	7.6
Upper aerodigestive tract	YD8	8.5
Urinary tract	5637	7.5
Urinary tract	639V	8.2
Urinary tract	647V	7.5
Urinary tract	BC3C	6.9
Urinary tract	BFTC905	8.3
Urinary tract	CAL29	7.3
Urinary tract	HS172T	6.8
Urinary tract	HT1197	7.1
Urinary tract	HT1376	8.3
Urinary tract	J82	7.8
Urinary tract	JMSU1	8.3
Urinary tract	KMBC2	7.6
Urinary tract	KU1919	7.4
Urinary tract	RT11284	7.3
Urinary tract	RT112	7.1
Urinary tract	RT4	8.2
Urinary tract	SCABER	7.6
Urinary tract	SW1710	7.3
Urinary tract	SW780	8.1
Urinary tract	T24	7.4
Urinary tract	TCCSUP	7.3
Urinary tract	UMUC1	6.9
Urinary tract	UMUC3	7.9
Urinary tract	VMCUB1	8

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	12
Adrenal gland	20.1
Appendix	16.5
Bone marrow	7.2
Breast	15.6
Cerebral cortex	17.2
Cervix, uterine	21.1
Colon	17.3
Duodenum	27.7
Endometrium	21.8
Epididymis	15.5
Esophagus	13.2
Fallopian tube	27.4
Gallbladder	18.1
Heart muscle	6.7
Kidney	12.6
Liver	7.7
Lung	21.3
Lymph node	17.3
Ovary	22.5
Pancreas	2.5
Parathyroid gland	30.6
Placenta	15.5
Prostate	21
Rectum	19.5
Salivary gland	5.6
Seminal vesicle	15.5
Skeletal muscle	3.8
Skin	25.4
Small intestine	22.9
Smooth muscle	20.4
Spleen	19.4
Stomach	13.2
Testis	10.5
Thyroid gland	28.9
Tonsil	15.2
Urinary bladder	18

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
28693517	Overexpression	Nasopharyngeal Carcinoma	JMJD2A was expressed at high levels in NPC tumor tissues and cell lines.

Summary
Symbol	KDM4A
Name	lysine demethylase 4A
Aliases	KIAA0677; JHDM3A; TDRD14A; jumonji C domain-containing histone demethylase 3A; tudor domain containing 14A; ......
Location	1p34.2-p34.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

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Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.449	2.08e-21	12.9	64.9	22.3	Neutral
BRCA	Breast invasive carcinoma	1075	0.564	4.09e-91	27.3	57.3	15.4	Neutral
CESC	Cervical and endocervical cancers	292	0.412	2.13e-13	4.5	63.4	32.2	Neutral
COAD	Colon adenocarcinoma	449	0.427	2.34e-21	24.5	70.4	5.1	Neutral
ESCA	Esophageal carcinoma	183	0.422	2.75e-09	25.7	54.6	19.7	Neutral
GBM	Glioblastoma multiforme	147	0.228	0.00553	5.4	76.9	17.7	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.403	1.91e-21	12.1	73	15	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.366	4.45e-18	14.7	82.5	2.9	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.398	2.32e-12	13.9	84.7	1.4	Neutral
LAML	Acute Myeloid Leukemia	166	0.018	0.816	0	97.6	2.4	Neutral
LGG	Brain Lower Grade Glioma	513	0.671	2.59e-68	35.9	61.2	2.9	Loss
LIHC	Liver hepatocellular carcinoma	364	0.426	1.74e-17	27.7	61.3	11	Neutral
LUAD	Lung adenocarcinoma	512	0.426	5.38e-24	18.4	54.5	27.1	Neutral
LUSC	Lung squamous cell carcinoma	498	0.498	1.25e-32	33.5	49.4	17.1	Loss
OV	Ovarian serous cystadenocarcinoma	300	0.619	3.84e-33	10.3	43.3	46.3	Gain
PAAD	Pancreatic adenocarcinoma	177	0.634	2.91e-21	23.2	70.6	6.2	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.704	1.6e-25	64.8	34	1.2	Loss
PRAD	Prostate adenocarcinoma	491	0.267	1.83e-09	8.1	91	0.8	Neutral
READ	Rectum adenocarcinoma	164	0.494	1.75e-11	29.9	65.2	4.9	Neutral
SARC	Sarcoma	255	0.386	1.76e-10	12.5	58.4	29	Neutral
SKCM	Skin Cutaneous Melanoma	367	0.509	1.39e-25	15.3	63.2	21.5	Neutral
STAD	Stomach adenocarcinoma	413	0.378	1.78e-15	17.9	71.2	10.9	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.253	0.0018	16.7	59.3	24	Neutral
THCA	Thyroid carcinoma	497	0.138	0.0021	0.8	98.6	0.6	Neutral
THYM	Thymoma	119	0.107	0.248	5.9	93.3	0.8	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.395	1.61e-21	5.2	82.3	12.5	Neutral

Summary
Symbol	KDM4A
Name	lysine demethylase 4A
Aliases	KIAA0677; JHDM3A; TDRD14A; jumonji C domain-containing histone demethylase 3A; tudor domain containing 14A; ......
Location	1p34.2-p34.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.245	3.53e-07	17	408	-0.437	1.57e-09	Decreased
BRCA	Breast invasive carcinoma	-0.218	8.79e-11	83	785	-0.002	0.0977	NS/NA
CESC	Cervical and endocervical cancers	-0.293	1.83e-07	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.227	4.71e-05	19	297	0.004	0.00023	NS/NA
ESCA	Esophageal carcinoma	-0.287	5.31e-05	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.209	0.0949	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.241	1.56e-08	20	522	0.001	0.408	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.138	0.0108	24	319	0.007	3.88e-10	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.288	4.79e-07	23	275	0.009	0.146	NS/NA
LAML	Acute Myeloid Leukemia	-0.53	0	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.545	0	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.296	1.02e-09	41	373	0.006	0.872	NS/NA
LUAD	Lung adenocarcinoma	-0.192	2.44e-05	21	456	-0.009	0.129	NS/NA
LUSC	Lung squamous cell carcinoma	-0.296	5.2e-09	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.767	0.0214	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.245	0.000878	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.592	0	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.132	0.00226	35	498	-0.002	0.522	NS/NA
READ	Rectum adenocarcinoma	-0.411	2.28e-05	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.192	0.00184	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.271	2.62e-09	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.221	1.75e-05	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.281	0.000391	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.061	0.15	50	509	-0.003	0.0803	NS/NA
THYM	Thymoma	-0.182	0.0446	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.184	6.55e-05	34	431	-0.001	0.371	NS/NA

Summary
Symbol	KDM4A
Name	lysine demethylase 4A
Aliases	KIAA0677; JHDM3A; TDRD14A; jumonji C domain-containing histone demethylase 3A; tudor domain containing 14A; ......
Location	1p34.2-p34.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	2	Medium
Appendix	1	Low
Bone marrow	1	Low
Breast	1	Low
Bronchus	1	Low
Caudate	3	High
Cerebellum	3	High
Cerebral cortex	3	High
Cervix, uterine	1	Low
Colon	1	Low
Duodenum	3	High
Endometrium	1	Low
Epididymis	2	Medium
Fallopian tube	1	Low
Gallbladder	2	Medium
Heart muscle	1	Low
Hippocampus	3	High
Kidney	1	Low
Liver	1	Low
Lung	2	Medium
Lymph node	2	Medium
Nasopharynx	1	Low
Oral mucosa	1	Low
Ovary	1	Low
Pancreas	0	Not detected
Placenta	1	Low
Prostate	1	Low
Rectum	1	Low
Salivary gland	0	Not detected
Seminal vesicle	1	Low
Skeletal muscle	1	Low
Skin	2	Medium
Small intestine	2	Medium
Smooth muscle	0	Not detected
Soft tissue	1	Low
Spleen	2	Medium
Stomach	1	Low
Testis	3	High
Thyroid gland	2	Medium
Tonsil	2	Medium
Urinary bladder	1	Low

Summary
Symbol	KDM4A
Name	lysine demethylase 4A
Aliases	KIAA0677; JHDM3A; TDRD14A; jumonji C domain-containing histone demethylase 3A; tudor domain containing 14A; ......
Location	1p34.2-p34.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.0565	NS	24476821
BRCA	Breast invasive carcinoma	521	0.00811	Significant	23000897
COAD	Colon adenocarcinoma	149	0.163	NS	22810696
GBM	Glioblastoma multiforme	157	0.000336	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	0.0295	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.00097	Significant	26536169
LGG	Brain Lower Grade Glioma	513	2.49e-55	Significant	26824661
LUAD	Lung adenocarcinoma	230	0.00505	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	0.334	NS	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.0864	NS	21720365
PRAD	Prostate adenocarcinoma	333	0.00694	Significant	26544944
READ	Rectum adenocarcinoma	67	0.0644	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.0139	Significant	26091043
STAD	Stomach adenocarcinoma	277	0.000341	Significant	25079317
THCA	Thyroid carcinoma	391	0.923	NS	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.0148	Significant	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	0.869	0.526	NS
BRCA	Breast invasive carcinoma	1079	0.882	0.59	NS
CESC	Cervical and endocervical cancers	291	1.478	0.259	NS
COAD	Colon adenocarcinoma	439	0.847	0.572	NS
ESCA	Esophageal carcinoma	184	0.705	0.244	NS
GBM	Glioblastoma multiforme	158	0.786	0.338	NS
HNSC	Head and Neck squamous cell carcinoma	518	0.689	0.0625	NS
KIRC	Kidney renal clear cell carcinoma	531	0.955	0.826	NS
KIRP	Kidney renal papillary cell carcinoma	287	1.001	0.999	NS
LAML	Acute Myeloid Leukemia	149	0.812	0.52	NS
LGG	Brain Lower Grade Glioma	511	3.118	0.00074	Shorter
LIHC	Liver hepatocellular carcinoma	365	1.413	0.16	NS
LUAD	Lung adenocarcinoma	502	0.634	0.0377	Longer
LUSC	Lung squamous cell carcinoma	494	0.788	0.231	NS
OV	Ovarian serous cystadenocarcinoma	303	0.972	0.897	NS
PAAD	Pancreatic adenocarcinoma	177	1.048	0.873	NS
PCPG	Pheochromocytoma and Paraganglioma	179	0.99	0.994	NS
PRAD	Prostate adenocarcinoma	497	1.358	0.761	NS
READ	Rectum adenocarcinoma	159	0.386	0.138	NS
SARC	Sarcoma	259	1.655	0.074	NS
SKCM	Skin Cutaneous Melanoma	459	1.367	0.1	NS
STAD	Stomach adenocarcinoma	388	0.517	0.00336	Longer
TGCT	Testicular Germ Cell Tumors	134	1	1	NS
THCA	Thyroid carcinoma	500	0.47	0.207	NS
THYM	Thymoma	119	0.943	0.949	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	1.419	0.218	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	-0.086	0.0829	NS
BRCA	Breast invasive carcinoma	1071	-0.048	0.12	NS
CESC	Cervical and endocervical cancers	167	0.084	0.279	NS
COAD	Colon adenocarcinoma	445	-0.146	0.00208	Lower
ESCA	Esophageal carcinoma	162	-0.076	0.336	NS
HNSC	Head and Neck squamous cell carcinoma	448	-0.121	0.0103	Lower
KIRC	Kidney renal clear cell carcinoma	531	0.016	0.714	NS
KIRP	Kidney renal papillary cell carcinoma	260	0.056	0.37	NS
LIHC	Liver hepatocellular carcinoma	347	-0.01	0.851	NS
LUAD	Lung adenocarcinoma	507	-0.039	0.376	NS
LUSC	Lung squamous cell carcinoma	497	-0.034	0.455	NS
OV	Ovarian serous cystadenocarcinoma	302	0.024	0.672	NS
PAAD	Pancreatic adenocarcinoma	176	-0.055	0.467	NS
READ	Rectum adenocarcinoma	156	-0.093	0.247	NS
SKCM	Skin Cutaneous Melanoma	410	-0.074	0.137	NS
STAD	Stomach adenocarcinoma	392	-0.057	0.26	NS
TGCT	Testicular Germ Cell Tumors	81	0.177	0.114	NS
THCA	Thyroid carcinoma	499	-0.052	0.251	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	-0.014	0.762	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	0.1	0.0996	NS
HNSC	Head and Neck squamous cell carcinoma	498	0.015	0.738	NS
KIRC	Kidney renal clear cell carcinoma	525	0.07	0.11	NS
LGG	Brain Lower Grade Glioma	514	0.185	2.46e-05	Higher
LIHC	Liver hepatocellular carcinoma	366	-0.093	0.0747	NS
OV	Ovarian serous cystadenocarcinoma	296	0.132	0.023	Higher
PAAD	Pancreatic adenocarcinoma	176	-0.024	0.756	NS
STAD	Stomach adenocarcinoma	406	-0.04	0.423	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.169	8.65e-05	Higher

Summary
Symbol	KDM4A
Name	lysine demethylase 4A
Aliases	KIAA0677; JHDM3A; TDRD14A; jumonji C domain-containing histone demethylase 3A; tudor domain containing 14A; ......
Location	1p34.2-p34.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	KDM4A
Name	lysine demethylase 4A
Aliases	KIAA0677; JHDM3A; TDRD14A; jumonji C domain-containing histone demethylase 3A; tudor domain containing 14A; ......
Location	1p34.2-p34.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for KDM4A.

Summary
Symbol	KDM4A
Name	lysine demethylase 4A
Aliases	KIAA0677; JHDM3A; TDRD14A; jumonji C domain-containing histone demethylase 3A; tudor domain containing 14A; ......
Location	1p34.2-p34.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
28693517	Nasopharyngeal Carcinoma	downstream	LDHA; LDH	Negative regulation; positive regulation	JMJD2A silencing decreased LDHA expression and the intracellular ATP level and increased LDH activity, lactate production and glucose utilization, while JMJD2A overexpression produced the opposite results.