CR2Cancer

Summary
Symbol	KDM5A
Name	lysine demethylase 5A
Aliases	RBBP2; JARID1A; retinoblastoma-binding protein 2; Jumonji, AT rich interactive domain 1A (RBBP2-like); jumon ......
Location	12p13.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

[ TOP ]

Domain

PF01388 ARID/BRIGHT DNA binding domain
PF02373 JmjC domain
PF02375 jmjN domain
PF00628 PHD-finger
PF08429 PLU-1-like protein
PF02928 C5HC2 zinc finger

Function

Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May stimulate transcription mediated by nuclear receptors. May be involved in transcriptional regulation of Hox proteins during cell differentiation. May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1 (By similarity).

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification erase	Histone methylation	H3K4me3	H3K4	17320163

> Gene Ontology [ TOP ]
Biological Process	GO:0006476 protein deacetylation GO:0006482 protein demethylation GO:0007283 spermatogenesis GO:0007548 sex differentiation GO:0007623 circadian rhythm GO:0008214 protein dealkylation GO:0008406 gonad development GO:0008584 male gonad development GO:0016570 histone modification GO:0016575 histone deacetylation GO:0016577 histone demethylation GO:0031056 regulation of histone modification GO:0031057 negative regulation of histone modification GO:0031063 regulation of histone deacetylation GO:0031064 negative regulation of histone deacetylation GO:0032922 circadian regulation of gene expression GO:0034720 histone H3-K4 demethylation GO:0035601 protein deacylation GO:0045137 development of primary sexual characteristics GO:0046546 development of primary male sexual characteristics GO:0046661 male sex differentiation GO:0048232 male gamete generation GO:0048511 rhythmic process GO:0048608 reproductive structure development GO:0051346 negative regulation of hydrolase activity GO:0061458 reproductive system development GO:0070076 histone lysine demethylation GO:0070988 demethylation GO:0090311 regulation of protein deacetylation GO:0098732 macromolecule deacylation GO:1901725 regulation of histone deacetylase activity GO:1901726 negative regulation of histone deacetylase activity GO:1902275 regulation of chromatin organization GO:1905268 negative regulation of chromatin organization
Molecular Function	GO:0003682 chromatin binding GO:0003713 transcription coactivator activity GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors GO:0031490 chromatin DNA binding GO:0032451 demethylase activity GO:0032452 histone demethylase activity GO:0043566 structure-specific DNA binding GO:0051213 dioxygenase activity
Cellular Component	GO:0000307 cyclin-dependent protein kinase holoenzyme complex GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex GO:0019908 nuclear cyclin-dependent protein kinase holoenzyme complex GO:0032806 carboxy-terminal domain protein kinase complex GO:0032993 protein-DNA complex GO:0061695 transferase complex, transferring phosphorus-containing groups GO:1902554 serine/threonine protein kinase complex GO:1902911 protein kinase complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-3214842: HDMs demethylate histones

Summary
Symbol	KDM5A
Name	lysine demethylase 5A
Aliases	RBBP2; JARID1A; retinoblastoma-binding protein 2; Jumonji, AT rich interactive domain 1A (RBBP2-like); jumon ......
Location	12p13.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM3954723	c.3497G>A	p.C1166Y	Substitution - Missense	Lung
COSM939277	c.2049T>C	p.C683C	Substitution - coding silent	Endometrium
COSM312105	c.3693A>G	p.V1231V	Substitution - coding silent	Soft_tissue
COSM5645136	c.3554A>T	p.H1185L	Substitution - Missense	Oesophagus
COSM3812056	c.769G>C	p.D257H	Substitution - Missense	Breast
COSM1676614	c.4499A>C	p.K1500T	Substitution - Missense	Large_intestine
COSM3384378	c.434G>A	p.R145H	Substitution - Missense	Pancreas
COSM4615515	c.3597_3598insA	p.G1200fs*7	Insertion - Frameshift	Large_intestine
COSM173429	c.3235G>A	p.D1079N	Substitution - Missense	Endometrium
COSM3710747	c.3044G>T	p.S1015I	Substitution - Missense	Upper_aerodigestive_tract
COSM1299359	c.2716G>T	p.E906*	Substitution - Nonsense	Prostate
COSM3460674	c.2315A>C	p.D772A	Substitution - Missense	Skin
COSM5657308	c.1133T>A	p.F378Y	Substitution - Missense	Soft_tissue
COSM4382860	c.5C>G	p.A2G	Substitution - Missense	Soft_tissue
COSM939384	c.1475T>G	p.I492S	Substitution - Missense	Endometrium
COSM4536185	c.2275G>A	p.D759N	Substitution - Missense	Skin
COSM939212	c.3091C>T	p.R1031C	Substitution - Missense	Endometrium
COSM6000512	c.1657T>C	p.Y553H	Substitution - Missense	Prostate
COSM161883	c.1303G>A	p.E435K	Substitution - Missense	Breast
COSM261527	c.2473G>T	p.E825*	Substitution - Nonsense	Stomach
COSM223510	c.4148C>T	p.S1383F	Substitution - Missense	Skin
COSM4430281	c.672+3A>G	p.?	Unknown	Oesophagus
COSM4041708	c.3561C>T	p.S1187S	Substitution - coding silent	Stomach
COSM240327	c.3470G>A	p.R1157H	Substitution - Missense	Prostate
COSM1193975	c.3786G>T	p.Q1262H	Substitution - Missense	Lung
COSM6000633	c.2116C>A	p.L706M	Substitution - Missense	Prostate
COSM4413679	c.2643C>T	p.G881G	Substitution - coding silent	Prostate
COSM4637679	c.3360C>T	p.T1120T	Substitution - coding silent	Large_intestine
COSM5951947	c.2783C>G	p.S928C	Substitution - Missense	Oesophagus
COSM3871582	c.2155C>T	p.R719C	Substitution - Missense	Skin
COSM1639127	c.2034A>G	p.A678A	Substitution - coding silent	Stomach
COSM4418536	c.1023C>G	p.V341V	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM4150054	c.4154A>C	p.E1385A	Substitution - Missense	Ovary
COSM5810807	c.30G>T	p.A10A	Substitution - coding silent	Liver
COSM1676614	c.4499A>C	p.K1500T	Substitution - Missense	Large_intestine
COSM226272	c.4261C>T	p.P1421S	Substitution - Missense	Skin
COSM3986891	c.4858T>C	p.C1620R	Substitution - Missense	Kidney
COSM1180774	c.3597delA	p.G1200fs*9	Deletion - Frameshift	Large_intestine
COSM302465	c.2718A>C	p.E906D	Substitution - Missense	Central_nervous_system
COSM352452	c.659G>T	p.R220L	Substitution - Missense	Lung
COSM22850	c.537+1G>A	p.?	Unknown	Skin
COSM287413	c.3710C>T	p.P1237L	Substitution - Missense	Large_intestine
COSM3710753	c.1308G>T	p.E436D	Substitution - Missense	Upper_aerodigestive_tract
COSM5361915	c.3092G>A	p.R1031H	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3359717	c.4016A>T	p.D1339V	Substitution - Missense	Kidney
COSM5937557	c.2978C>T	p.S993F	Substitution - Missense	Skin
COSM166089	c.95delC	p.P32fs*34	Deletion - Frameshift	Breast
COSM5427938	c.2163A>C	p.P721P	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM1285705	c.5121C>A	p.F1707L	Substitution - Missense	Autonomic_ganglia
COSM1322557	c.1963C>G	p.Q655E	Substitution - Missense	Ovary
COSM287413	c.3710C>T	p.P1237L	Substitution - Missense	Skin
COSM4041875	c.1615A>G	p.I539V	Substitution - Missense	Stomach
COSM5657061	c.5074A>G	p.K1692E	Substitution - Missense	Soft_tissue
COSM275660	c.4150G>A	p.E1384K	Substitution - Missense	Large_intestine
COSM1180774	c.3597delA	p.G1200fs*9	Deletion - Frameshift	Large_intestine
COSM431192	c.349C>A	p.L117M	Substitution - Missense	Breast
COSM3954744	c.2293G>A	p.V765I	Substitution - Missense	Lung
COSM939001	c.4538G>A	p.R1513Q	Substitution - Missense	Endometrium
COSM939214	c.3041G>A	p.G1014D	Substitution - Missense	Endometrium
COSM287413	c.3710C>T	p.P1237L	Substitution - Missense	Skin
COSM5763413	c.3416A>G	p.E1139G	Substitution - Missense	Large_intestine
COSM3812054	c.791G>A	p.R264Q	Substitution - Missense	Breast
COSM1180774	c.3597delA	p.G1200fs*9	Deletion - Frameshift	Large_intestine
COSM147386	c.3747G>A	p.L1249L	Substitution - coding silent	Stomach
COSM4042461	c.51A>G	p.P17P	Substitution - coding silent	Stomach
COSM939275	c.2086C>T	p.R696W	Substitution - Missense	Prostate
COSM4479602	c.2340C>T	p.L780L	Substitution - coding silent	Skin
COSM3460553	c.3711C>T	p.P1237P	Substitution - coding silent	Skin
COSM4913359	c.1476C>G	p.I492M	Substitution - Missense	Liver
COSM5051575	c.4395C>T	p.D1465D	Substitution - coding silent	Stomach
COSM693863	c.498C>G	p.L166L	Substitution - coding silent	Lung
COSM939271	c.2345G>A	p.R782Q	Substitution - Missense	Oesophagus
COSM548236	c.3649C>T	p.R1217W	Substitution - Missense	Pituitary
COSM2068399	c.491G>T	p.R164I	Substitution - Missense	Large_intestine
COSM3812002	c.2020C>T	p.R674W	Substitution - Missense	Breast
COSM6000633	c.2116C>A	p.L706M	Substitution - Missense	Prostate
COSM5198875	c.2274_2275insA	p.D759fs*4	Insertion - Frameshift	Upper_aerodigestive_tract
COSM2067307	c.1406C>T	p.P469L	Substitution - Missense	Large_intestine
COSM2066501	c.3123G>A	p.P1041P	Substitution - coding silent	Large_intestine
COSM2007600	c.227G>A	p.R76H	Substitution - Missense	Large_intestine
COSM939250	c.2662C>T	p.L888F	Substitution - Missense	Endometrium
COSM1659001	c.2928C>A	p.S976R	Substitution - Missense	Salivary_gland
COSM3688201	c.2087G>A	p.R696Q	Substitution - Missense	Large_intestine
COSM289706	c.3715C>T	p.R1239W	Substitution - Missense	Large_intestine
COSM939212	c.3091C>T	p.R1031C	Substitution - Missense	Large_intestine
COSM5945235	c.2524C>T	p.Q842*	Substitution - Nonsense	Haematopoietic_and_lymphoid_tissue
COSM939268	c.2454G>T	p.R818R	Substitution - coding silent	Endometrium
COSM1180774	c.3597delA	p.G1200fs*9	Deletion - Frameshift	Large_intestine
COSM1361090	c.4170G>A	p.M1390I	Substitution - Missense	Large_intestine
COSM5598416	c.3795C>T	p.A1265A	Substitution - coding silent	Skin
COSM1361194	c.1808G>A	p.R603Q	Substitution - Missense	Large_intestine
COSM6000635	c.1861G>A	p.A621T	Substitution - Missense	Prostate
COSM939609	c.645G>A	p.P215P	Substitution - coding silent	Endometrium
COSM230693	c.3781C>T	p.R1261W	Substitution - Missense	Skin
COSM459507	c.955C>G	p.H319D	Substitution - Missense	Cervix
COSM4041878	c.1346C>T	p.P449L	Substitution - Missense	Stomach
COSM4401899	c.2287T>G	p.L763V	Substitution - Missense	Skin
COSM5945245	c.1445G>A	p.W482*	Substitution - Nonsense	Haematopoietic_and_lymphoid_tissue
COSM4819236	c.674C>G	p.S225*	Substitution - Nonsense	Cervix
COSM1676618	c.920A>C	p.K307T	Substitution - Missense	Large_intestine
COSM1180774	c.3597delA	p.G1200fs*9	Deletion - Frameshift	Large_intestine
COSM5478236	c.3999A>G	p.R1333R	Substitution - coding silent	Large_intestine
COSM5945243	c.1773G>A	p.W591*	Substitution - Nonsense	Haematopoietic_and_lymphoid_tissue
COSM1726485	c.3254G>A	p.S1085N	Substitution - Missense	Liver
COSM6000396	c.2295A>G	p.V765V	Substitution - coding silent	Prostate
COSM1299353	c.3493A>G	p.I1165V	Substitution - Missense	Urinary_tract
COSM312105	c.3693A>G	p.V1231V	Substitution - coding silent	Lung
COSM3398705	c.3571C>T	p.L1191F	Substitution - Missense	Central_nervous_system
COSM939008	c.4283G>A	p.S1428N	Substitution - Missense	Endometrium
COSM1756776	c.2233C>T	p.R745C	Substitution - Missense	Urinary_tract
COSM4041575	c.4820A>G	p.E1607G	Substitution - Missense	Stomach
COSM5721869	c.2979C>T	p.S993S	Substitution - coding silent	Skin
COSM1746934	c.881A>T	p.Y294F	Substitution - Missense	Urinary_tract
COSM5916231	c.3100C>T	p.P1034S	Substitution - Missense	Skin
COSM415867	c.3037-1G>C	p.?	Unknown	Urinary_tract
COSM1166673	c.965G>A	p.C322Y	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3460383	c.5143A>G	p.M1715V	Substitution - Missense	Skin
COSM2068405	c.432T>C	p.S144S	Substitution - coding silent	Upper_aerodigestive_tract
COSM3871582	c.2155C>T	p.R719C	Substitution - Missense	Skin
COSM4446294	c.2541+3G>A	p.?	Unknown	Skin
COSM4627079	c.3048T>C	p.N1016N	Substitution - coding silent	Large_intestine
COSM4446292	c.4075-3C>T	p.?	Unknown	Skin
COSM275660	c.4150G>A	p.E1384K	Substitution - Missense	Lung
COSM4643712	c.2765T>C	p.M922T	Substitution - Missense	Large_intestine
COSM4041704	c.3898C>T	p.L1300F	Substitution - Missense	Stomach
COSM1285701	c.3083C>T	p.A1028V	Substitution - Missense	Autonomic_ganglia
COSM3792582	c.2355G>A	p.R785R	Substitution - coding silent	Urinary_tract
COSM4384660	c.1370C>T	p.A457V	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4147042	c.1413C>T	p.L471L	Substitution - coding silent	Thyroid
COSM255249	c.4470+6G>T	p.?	Unknown	Central_nervous_system
COSM5747351	c.3029C>T	p.A1010V	Substitution - Missense	Pancreas
COSM2066717	c.2511G>A	p.P837P	Substitution - coding silent	Large_intestine
COSM5361915	c.3092G>A	p.R1031H	Substitution - Missense	Large_intestine
COSM4041706	c.3758C>T	p.A1253V	Substitution - Missense	Stomach
COSM693234	c.4208C>T	p.S1403F	Substitution - Missense	Lung
COSM4694998	c.2131A>C	p.M711L	Substitution - Missense	Large_intestine
COSM939273	c.2161C>A	p.P721T	Substitution - Missense	Endometrium
COSM6000633	c.2116C>A	p.L706M	Substitution - Missense	Prostate
COSM4453198	c.2636A>T	p.D879V	Substitution - Missense	Skin
COSM4832126	c.3948C>T	p.F1316F	Substitution - coding silent	Cervix
COSM1211761	c.1406C>A	p.P469Q	Substitution - Missense	Stomach
COSM4851572	c.3845G>A	p.R1282H	Substitution - Missense	Biliary_tract
COSM4482601	c.2623C>T	p.Q875*	Substitution - Nonsense	Skin
COSM1299359	c.2716G>T	p.E906*	Substitution - Nonsense	Urinary_tract
COSM939270	c.2379C>A	p.T793T	Substitution - coding silent	Endometrium
COSM939014	c.4221G>T	p.K1407N	Substitution - Missense	Endometrium
COSM5567406	c.4282A>T	p.S1428C	Substitution - Missense	Prostate
COSM1628576	c.4395C>A	p.D1465E	Substitution - Missense	Liver
COSM261531	c.713A>C	p.K238T	Substitution - Missense	Large_intestine
COSM693245	c.4848A>C	p.A1616A	Substitution - coding silent	Lung
COSM1236245	c.1810C>T	p.R604C	Substitution - Missense	Autonomic_ganglia
COSM4765535	c.3598_3599insA	p.G1200fs*7	Insertion - Frameshift	Stomach
COSM5944616	c.4124_4125insT	p.D1376fs*1	Insertion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM1361140	c.3601T>C	p.S1201P	Substitution - Missense	Large_intestine
COSM3811942	c.4437A>C	p.P1479P	Substitution - coding silent	Breast
COSM3710745	c.3061G>T	p.E1021*	Substitution - Nonsense	Upper_aerodigestive_tract
COSM5721869	c.2979C>T	p.S993S	Substitution - coding silent	Skin
COSM4694996	c.2530C>T	p.R844W	Substitution - Missense	Large_intestine
COSM4775691	c.2427-6C>T	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM4748313	c.1332T>G	p.N444K	Substitution - Missense	Stomach
COSM272845	c.5042A>T	p.E1681V	Substitution - Missense	Large_intestine
COSM1322569	c.4357C>T	p.L1453F	Substitution - Missense	Ovary
COSM4041772	c.2682G>A	p.L894L	Substitution - coding silent	Stomach
COSM3811944	c.4098T>C	p.S1366S	Substitution - coding silent	Breast
COSM939296	c.1912G>T	p.E638*	Substitution - Nonsense	Endometrium
COSM5369314	c.1768G>C	p.D590H	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5480719	c.165+5C>T	p.?	Unknown	Large_intestine
COSM693859	c.402C>A	p.T134T	Substitution - coding silent	Lung
COSM5581452	c.3002C>T	p.A1001V	Substitution - Missense	Skin
COSM4834737	c.3222G>A	p.L1074L	Substitution - coding silent	Cervix
COSM3460557	c.3602C>T	p.S1201F	Substitution - Missense	Skin
COSM245196	c.744T>A	p.V248V	Substitution - coding silent	Prostate
COSM1361192	c.1943G>A	p.R648Q	Substitution - Missense	Large_intestine
COSM71281	c.3685C>T	p.L1229F	Substitution - Missense	Ovary
COSM240329	c.2033_2044del12	p.R680_C683delRTTC	Deletion - In frame	Prostate
COSM1128597	c.3515G>T	p.G1172V	Substitution - Missense	Prostate
COSM4836251	c.3283G>A	p.E1095K	Substitution - Missense	Cervix
COSM145541	c.2758G>T	p.D920Y	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3460459	c.4274C>T	p.P1425L	Substitution - Missense	Skin
COSM1746936	c.755C>T	p.A252V	Substitution - Missense	Urinary_tract
COSM1746936	c.755C>T	p.A252V	Substitution - Missense	Urinary_tract
COSM3398703	c.3666G>A	p.R1222R	Substitution - coding silent	Central_nervous_system
COSM5020164	c.3197C>G	p.S1066C	Substitution - Missense	Soft_tissue
COSM4776605	c.3362G>C	p.R1121T	Substitution - Missense	Breast
COSM468357	c.1609G>A	p.V537I	Substitution - Missense	Kidney
COSM3871534	c.4298G>A	p.R1433Q	Substitution - Missense	Skin
COSM4694988	c.4697G>T	p.R1566I	Substitution - Missense	Large_intestine
COSM2007600	c.227G>A	p.R76H	Substitution - Missense	Large_intestine
COSM4618994	c.2145T>C	p.C715C	Substitution - coding silent	Large_intestine
COSM1180774	c.3597delA	p.G1200fs*9	Deletion - Frameshift	Large_intestine
COSM4604610	c.1930G>A	p.E644K	Substitution - Missense	Upper_aerodigestive_tract
COSM261529	c.1456G>A	p.D486N	Substitution - Missense	Large_intestine
COSM939216	c.3016G>A	p.A1006T	Substitution - Missense	Endometrium
COSM3460676	c.2130C>T	p.P710P	Substitution - coding silent	Skin
COSM348659	c.2908A>T	p.S970C	Substitution - Missense	Lung
COSM4851572	c.3845G>A	p.R1282H	Substitution - Missense	Cervix
COSM4152825	c.774A>T	p.K258N	Substitution - Missense	Kidney
COSM1180774	c.3597delA	p.G1200fs*9	Deletion - Frameshift	Large_intestine
COSM5721869	c.2979C>T	p.S993S	Substitution - coding silent	Skin
COSM4041798	c.2098C>T	p.L700F	Substitution - Missense	Stomach
COSM6007813	c.3322G>C	p.E1108Q	Substitution - Missense	Prostate
COSM468359	c.1578T>C	p.F526F	Substitution - coding silent	Kidney
COSM4394068	c.1774-1G>A	p.?	Unknown	Skin
COSM693971	c.1658A>G	p.Y553C	Substitution - Missense	Lung
COSM4613324	c.3276delA	p.V1093fs*1	Deletion - Frameshift	Large_intestine
COSM1180774	c.3597delA	p.G1200fs*9	Deletion - Frameshift	Stomach
COSM5977696	c.2242G>A	p.E748K	Substitution - Missense	Central_nervous_system
COSM1211761	c.1406C>A	p.P469Q	Substitution - Missense	Large_intestine
COSM1211765	c.4773A>C	p.K1591N	Substitution - Missense	Large_intestine
COSM1756778	c.1999G>C	p.E667Q	Substitution - Missense	Urinary_tract
COSM939555	c.796C>T	p.R266*	Substitution - Nonsense	Endometrium
COSM1180774	c.3597delA	p.G1200fs*9	Deletion - Frameshift	Large_intestine
COSM2066293	c.4048C>T	p.R1350*	Substitution - Nonsense	Large_intestine
COSM5361915	c.3092G>A	p.R1031H	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3460559	c.3450C>T	p.A1150A	Substitution - coding silent	Skin
COSM5685937	c.2151-16_2151-3delTTTTTTTTTTTTGT	p.?	Unknown	Soft_tissue
COSM5696909	c.3807A>G	p.L1269L	Substitution - coding silent	Soft_tissue
COSM1236245	c.1810C>T	p.R604C	Substitution - Missense	Autonomic_ganglia
COSM5198875	c.2274_2275insA	p.D759fs*4	Insertion - Frameshift	Breast
COSM939934	c.339A>C	p.K113N	Substitution - Missense	Endometrium
COSM5945237	c.2491C>T	p.Q831*	Substitution - Nonsense	Haematopoietic_and_lymphoid_tissue
COSM693913	c.1076G>T	p.R359L	Substitution - Missense	Lung
COSM1361268	c.692G>A	p.S231N	Substitution - Missense	Large_intestine
COSM261527	c.2473G>T	p.E825*	Substitution - Nonsense	Large_intestine
COSM4449080	c.166-1G>A	p.?	Unknown	Skin
COSM3710753	c.1308G>T	p.E436D	Substitution - Missense	Upper_aerodigestive_tract
COSM4827334	c.445C>G	p.L149V	Substitution - Missense	Cervix
COSM939484	c.1268C>T	p.P423L	Substitution - Missense	Oesophagus
COSM1211763	c.541G>A	p.V181M	Substitution - Missense	Large_intestine
COSM3460999	c.1027G>A	p.E343K	Substitution - Missense	Skin
COSM939281	c.1991_1993delAAG	p.E664delE	Deletion - In frame	Endometrium
COSM5693360	c.1507T>C	p.W503R	Substitution - Missense	Soft_tissue
COSM1180774	c.3597delA	p.G1200fs*9	Deletion - Frameshift	Stomach
COSM3460701	c.1871C>T	p.P624L	Substitution - Missense	Skin
COSM693888	c.790C>T	p.R264*	Substitution - Nonsense	Lung
COSM224415	c.4366G>A	p.V1456I	Substitution - Missense	Skin
COSM939248	c.2678G>A	p.R893Q	Substitution - Missense	Endometrium
COSM3772615	c.2045C>T	p.T682I	Substitution - Missense	Pancreas
COSM939298	c.1883A>G	p.D628G	Substitution - Missense	Endometrium
COSM3368797	c.3484A>C	p.K1162Q	Substitution - Missense	Thyroid
COSM4384656	c.2333A>G	p.N778S	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5624227	c.572A>C	p.K191T	Substitution - Missense	Oesophagus
COSM4041979	c.1121A>G	p.K374R	Substitution - Missense	Stomach
COSM22859	c.3230_3231insC	p.T1078fs*12	Insertion - Frameshift	Skin
COSM4384658	c.2225G>T	p.W742L	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4604331	c.1413C>G	p.L471L	Substitution - coding silent	Upper_aerodigestive_tract
COSM939275	c.2086C>T	p.R696W	Substitution - Missense	Large_intestine
COSM4150076	c.3250G>A	p.G1084R	Substitution - Missense	Prostate
COSM5935885	c.3001G>A	p.A1001T	Substitution - Missense	Skin
COSM939492	c.1052C>T	p.A351V	Substitution - Missense	Endometrium
COSM1180774	c.3597delA	p.G1200fs*9	Deletion - Frameshift	Large_intestine
COSM4041817	c.1819C>T	p.R607C	Substitution - Missense	Stomach
COSM5458374	c.3967C>T	p.R1323W	Substitution - Missense	Large_intestine
COSM693863	c.498C>G	p.L166L	Substitution - coding silent	Endometrium
COSM230695	c.3568C>T	p.P1190S	Substitution - Missense	Skin
COSM4384664	c.43C>T	p.P15S	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3986897	c.4274C>G	p.P1425R	Substitution - Missense	Kidney
COSM4411541	c.4807T>G	p.S1603A	Substitution - Missense	Oesophagus
COSM3398695	c.4634T>G	p.L1545*	Substitution - Nonsense	Central_nervous_system
COSM5985835	c.604C>T	p.Q202*	Substitution - Nonsense	Haematopoietic_and_lymphoid_tissue
COSM939271	c.2345G>A	p.R782Q	Substitution - Missense	Endometrium
COSM2066717	c.2511G>A	p.P837P	Substitution - coding silent	Large_intestine
COSM3460555	c.3631C>T	p.L1211F	Substitution - Missense	Skin
COSM5945239	c.1936G>T	p.E646*	Substitution - Nonsense	Haematopoietic_and_lymphoid_tissue
COSM4384654	c.3442A>G	p.N1148D	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5020672	c.2423A>T	p.H808L	Substitution - Missense	Soft_tissue
COSM5778330	c.3840C>T	p.S1280S	Substitution - coding silent	Breast
COSM4475258	c.1974C>T	p.V658V	Substitution - coding silent	Skin
COSM1562160	c.4211C>A	p.S1404Y	Substitution - Missense	Large_intestine
COSM939248	c.2678G>A	p.R893Q	Substitution - Missense	Endometrium
COSM1360988	c.5040T>A	p.A1680A	Substitution - coding silent	Large_intestine
COSM5601681	c.2104C>T	p.H702Y	Substitution - Missense	Skin
COSM5478287	c.337A>C	p.K113Q	Substitution - Missense	Large_intestine
COSM4041774	c.2564A>T	p.E855V	Substitution - Missense	Stomach
COSM4613321	c.4421delT	p.L1474fs*26	Deletion - Frameshift	Large_intestine
COSM693123	c.2775G>C	p.L925L	Substitution - coding silent	Lung
COSM3811920	c.5138T>C	p.L1713P	Substitution - Missense	Breast
COSM459505	c.797G>A	p.R266Q	Substitution - Missense	Cervix
COSM4384652	c.3499C>T	p.R1167C	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5020872	c.3519T>C	p.F1173F	Substitution - coding silent	Soft_tissue
COSM289706	c.3715C>T	p.R1239W	Substitution - Missense	Oesophagus
COSM5967043	c.1703G>T	p.R568L	Substitution - Missense	Pituitary
COSM693234	c.4208C>T	p.S1403F	Substitution - Missense	Biliary_tract
COSM1236245	c.1810C>T	p.R604C	Substitution - Missense	Oesophagus
COSM1180774	c.3597delA	p.G1200fs*9	Deletion - Frameshift	Large_intestine
COSM939484	c.1268C>T	p.P423L	Substitution - Missense	Endometrium
COSM1756778	c.1999G>C	p.E667Q	Substitution - Missense	Urinary_tract
COSM2066862	c.1835C>T	p.S612L	Substitution - Missense	Skin
COSM693861	c.469C>G	p.L157V	Substitution - Missense	Lung
COSM1180774	c.3597delA	p.G1200fs*9	Deletion - Frameshift	Breast
COSM4441611	c.4262C>A	p.P1421Q	Substitution - Missense	Large_intestine
COSM282119	c.4619A>T	p.K1540M	Substitution - Missense	Large_intestine
COSM939218	c.2946G>T	p.K982N	Substitution - Missense	Endometrium
COSM4694994	c.3044G>C	p.S1015T	Substitution - Missense	Large_intestine
COSM4042019	c.688G>C	p.V230L	Substitution - Missense	Stomach
COSM4995123	c.3914C>A	p.A1305D	Substitution - Missense	Upper_aerodigestive_tract
COSM1180774	c.3597delA	p.G1200fs*9	Deletion - Frameshift	Large_intestine
COSM939212	c.3091C>T	p.R1031C	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5935887	c.4868C>T	p.P1623L	Substitution - Missense	Skin
COSM5021085	c.4435C>A	p.P1479T	Substitution - Missense	Soft_tissue
COSM5510561	c.5067C>T	p.N1689N	Substitution - coding silent	Biliary_tract
COSM4152815	c.2897+3G>A	p.?	Unknown	Kidney
COSM3710747	c.3044G>T	p.S1015I	Substitution - Missense	Upper_aerodigestive_tract
COSM4384662	c.970A>G	p.I324V	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5945241	c.1865C>T	p.A622V	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3871582	c.2155C>T	p.R719C	Substitution - Missense	Skin
COSM939548	c.984T>C	p.P328P	Substitution - coding silent	Endometrium
COSM4904466	c.4203T>C	p.A1401A	Substitution - coding silent	Skin
COSM1756774	c.4362G>A	p.M1454I	Substitution - Missense	Urinary_tract
COSM5685594	c.3837G>T	p.L1279F	Substitution - Missense	Soft_tissue
COSM1211757	c.1115A>C	p.N372T	Substitution - Missense	Large_intestine
COSM5774004	c.3330G>A	p.L1110L	Substitution - coding silent	Breast
COSM939553	c.851G>A	p.G284D	Substitution - Missense	Endometrium
COSM2065407	c.4710G>A	p.K1570K	Substitution - coding silent	Large_intestine
COSM1756774	c.4362G>A	p.M1454I	Substitution - Missense	Urinary_tract
COSM1243336	c.820G>A	p.A274T	Substitution - Missense	Oesophagus
COSM4041748	c.3122C>T	p.P1041L	Substitution - Missense	Stomach
COSM431138	c.735G>A	p.G245G	Substitution - coding silent	Breast
COSM5945247	c.1329G>A	p.W443*	Substitution - Nonsense	Haematopoietic_and_lymphoid_tissue
COSM1180774	c.3597delA	p.G1200fs*9	Deletion - Frameshift	Large_intestine
COSM4487792	c.322C>T	p.P108S	Substitution - Missense	Skin
COSM4645851	c.3862G>A	p.A1288T	Substitution - Missense	Large_intestine
COSM245194	c.1703G>A	p.R568H	Substitution - Missense	Prostate
COSM693164	c.3721C>T	p.P1241S	Substitution - Missense	Lung
COSM3461474	c.342C>T	p.I114I	Substitution - coding silent	Skin
COSM4041796	c.2139G>T	p.K713N	Substitution - Missense	Stomach
COSM431086	c.2815G>C	p.E939Q	Substitution - Missense	Breast
COSM5721869	c.2979C>T	p.S993S	Substitution - coding silent	Skin
COSM3376238	c.4592A>C	p.E1531A	Substitution - Missense	Pancreas
COSM2068210	c.659G>A	p.R220H	Substitution - Missense	Large_intestine
COSM6000398	c.277C>G	p.Q93E	Substitution - Missense	Prostate
COSM4821111	c.2344C>T	p.R782*	Substitution - Nonsense	Cervix
COSM379581	c.1864G>T	p.A622S	Substitution - Missense	Lung
COSM5988563	c.868T>C	p.F290L	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1285703	c.3219G>T	p.V1073V	Substitution - coding silent	Autonomic_ganglia
COSM4847231	c.4513G>C	p.D1505H	Substitution - Missense	Cervix
COSM3710745	c.3061G>T	p.E1021*	Substitution - Nonsense	Upper_aerodigestive_tract
COSM4694992	c.3596_3597delAA	p.K1199fs*7	Deletion - Frameshift	Large_intestine
COSM939275	c.2086C>T	p.R696W	Substitution - Missense	Stomach
COSM5916229	c.1784G>A	p.G595E	Substitution - Missense	Skin
COSM3792592	c.1583C>G	p.S528C	Substitution - Missense	Urinary_tract
COSM939246	c.2821G>A	p.A941T	Substitution - Missense	Endometrium
COSM1211759	c.4537C>T	p.R1513W	Substitution - Missense	Large_intestine
COSM5960569	c.879C>T	p.L293L	Substitution - coding silent	Breast
COSM1361136	c.3982G>A	p.V1328M	Substitution - Missense	Large_intestine
COSM4385661	c.3363_3364insAGA	p.R1121_D1122insR	Insertion - In frame	Haematopoietic_and_lymphoid_tissue
COSM4694990	c.4265G>A	p.R1422K	Substitution - Missense	Large_intestine
COSM4647600	c.4317G>A	p.V1439V	Substitution - coding silent	Large_intestine
COSM403343	c.3660G>T	p.R1220S	Substitution - Missense	Lung
COSM3986938	c.671A>G	p.Q224R	Substitution - Missense	Kidney
COSM2068407	c.417G>A	p.W139*	Substitution - Nonsense	Haematopoietic_and_lymphoid_tissue
COSM1194640	c.1917G>T	p.L639F	Substitution - Missense	Lung
COSM5945233	c.3044G>A	p.S1015N	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM939279	c.2022G>A	p.R674R	Substitution - coding silent	Endometrium
COSM468385	c.878T>C	p.L293P	Substitution - Missense	Kidney
COSM3461001	c.974C>T	p.P325L	Substitution - Missense	Skin
COSM693632	c.190G>C	p.E64Q	Substitution - Missense	Lung
COSM1361277	c.570A>C	p.E190D	Substitution - Missense	Large_intestine
COSM3739656	c.2776A>G	p.I926V	Substitution - Missense	Liver
COSM230693	c.3781C>T	p.R1261W	Substitution - Missense	Biliary_tract
COSM269426	c.3766T>C	p.W1256R	Substitution - Missense	Large_intestine
COSM5920440	c.4354G>A	p.E1452K	Substitution - Missense	Skin
COSM1628576	c.4395C>A	p.D1465E	Substitution - Missense	Liver
COSM145541	c.2758G>T	p.D920Y	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4843280	c.991C>A	p.P331T	Substitution - Missense	Cervix
COSM939300	c.1790A>C	p.Q597P	Substitution - Missense	Endometrium
COSM5945231	c.3146C>T	p.A1049V	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4613324	c.3276delA	p.V1093fs*1	Deletion - Frameshift	Large_intestine
COSM2067961	c.1024G>A	p.A342T	Substitution - Missense	Large_intestine
COSM1756776	c.2233C>T	p.R745C	Substitution - Missense	Urinary_tract
COSM1180774	c.3597delA	p.G1200fs*9	Deletion - Frameshift	Large_intestine
COSM939003	c.4478G>T	p.S1493I	Substitution - Missense	Endometrium
COSM4473743	c.1870C>T	p.P624S	Substitution - Missense	Skin
COSM415871	c.3697C>T	p.L1233F	Substitution - Missense	Urinary_tract
COSM1562151	c.1902G>A	p.M634I	Substitution - Missense	Large_intestine
COSM5033358	c.4133A>C	p.E1378A	Substitution - Missense	Oesophagus
COSM5945229	c.3930+2C>T	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM939275	c.2086C>T	p.R696W	Substitution - Missense	Endometrium
COSM1166673	c.965G>A	p.C322Y	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4974262	c.1126G>C	p.D376H	Substitution - Missense	Oesophagus
COSM4150076	c.3250G>A	p.G1084R	Substitution - Missense	Ovary
COSM1676616	c.3365A>G	p.D1122G	Substitution - Missense	Lung
COSM287413	c.3710C>T	p.P1237L	Substitution - Missense	Skin
COSM4041764	c.2715C>T	p.D905D	Substitution - coding silent	Stomach
COSM3359719	c.3265A>T	p.R1089W	Substitution - Missense	Kidney
COSM1676616	c.3365A>G	p.D1122G	Substitution - Missense	Central_nervous_system

> Text Mining based Variations

[ TOP ]

PMID	Variation	Cancer	Evidence
27114462	Mutation	Acute megakaryoblastic Leukemia	To assess frequencies and outcome parameters of recurrent cytogenetic aberrations in AMKL, samples and clinical data of patients treated by the Associazione Italiana Ematologia Oncologia Pediatrica, Berlin-Frankfurt-Munster Study Group, Children's Oncology Group, Dutch Childhood Oncology Group, and the Saint Louis Hpital were collected, enabling us to screen 153 newly diagnosed pediatric AMKL cases for the aforementioned aberrations and to study their clinical characteristics and outcome. CBFA2T3/GLIS2 was identified in 16% of the cases; RBM15/MKL1, in 12%; NUP98/KDM5A and KMT2A rearrangements, in 9% each; and monosomy 7, in 6%.
23531517	Mutation	Acute Myeloid Leukemia	In this study we screened 105 pediatric AMKL cases to analyze the frequency of NUP98/JARID1A and other recurrent genetic abnormalities. NUP98/JARID1A was identified in 11/105 patients (10.5%).
16419055	Mutation	Leukemia	Using a NUP98-specific split-signal fluorescence in situ hybridization (FISH) probe combination, we analyzed 84 patients with acute myeloid leukemia (AML), acute lymphoblastic leukemia, or myelodysplastic syndrome with either normal karyotypes or 11p abnormalities to investigate whether there are unidentified 11p15 rearrangements. JARID1A, at 12p13, codes for retinoblastoma binding protein 2, a protein implicated in transcriptional regulation. This is the first report of JARID1A as a partner gene in leukemia.

Summary
Symbol	KDM5A
Name	lysine demethylase 5A
Aliases	RBBP2; JARID1A; retinoblastoma-binding protein 2; Jumonji, AT rich interactive domain 1A (RBBP2-like); jumon ......
Location	12p13.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

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Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
P29375	1111	S	Phosphoserine	-	No	None detected
P29375	1330	S	Phosphoserine	-	No	None detected
P29375	1331	S	Phosphoserine	-	No	None detected
P29375	1343	T	Phosphothreonine	-	No	None detected
P29375	1345	S	Phosphoserine	-	No	None detected
P29375	1438	S	Phosphoserine	-	No	None detected
P29375	1488	S	Phosphoserine	-	Yes	p.S1488I (cancer: UCEC)
P29375	1595	Y	Phosphotyrosine	-	No	None detected
P29375	1598	S	Phosphoserine	-	No	None detected
P29375	1603	S	Phosphoserine	-	Yes	p.S1603C (cancer: LUAD)
P29375	1666	S	Phosphoserine	-	No	None detected

Summary
Symbol	KDM5A
Name	lysine demethylase 5A
Aliases	RBBP2; JARID1A; retinoblastoma-binding protein 2; Jumonji, AT rich interactive domain 1A (RBBP2-like); jumon ......
Location	12p13.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

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Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	6.168	5.921	-0.171	0.227	NS
BRCA	Breast invasive carcinoma	112	1100	6.663	6.453	-0.156	0.0089	NS
CESC	Cervical and endocervical cancers	3	306	5.807	5.915	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	5.864	5.749	-0.087	0.303	NS
ESCA	Esophageal carcinoma	11	185	6.504	6.59	0.122	0.587	NS
GBM	Glioblastoma multiforme	5	166	4.887	5.543	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	5.98	6.224	0.259	0.0068	NS
KIRC	Kidney renal clear cell carcinoma	72	534	6.261	6.084	-0.171	0.00561	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	5.835	5.503	-0.296	0.00539	NS
LAML	Acute Myeloid Leukemia	0	173	NA	7.515	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	5.717	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	4.958	4.757	-0.2	0.0104	NS
LUAD	Lung adenocarcinoma	59	517	6.098	6.033	-0.036	0.658	NS
LUSC	Lung squamous cell carcinoma	51	501	6.07	6.369	0.298	0.000262	NS
OV	Ovarian serous cystadenocarcinoma	0	307	NA	6.131	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	5.913	5.919	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	6.09	5.216	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	6.093	5.791	-0.272	0.00023	NS
READ	Rectum adenocarcinoma	10	167	5.924	5.785	-0.137	0.584	NS
SARC	Sarcoma	2	263	5.148	5.61	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	6.071	6.123	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	5.968	6.278	0.252	0.00328	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	7.17	NA	NA	NA
THCA	Thyroid carcinoma	59	509	5.961	5.79	-0.153	0.0111	NS
THYM	Thymoma	2	120	6.553	6.189	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	5.782	5.592	-0.146	0.105	NS

> Cancer Cell Line Encyclopedia (CCLE)

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Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	7.8
Autonomic ganglia	CHP212	7.1
Autonomic ganglia	IMR32	8
Autonomic ganglia	KELLY	7
Autonomic ganglia	KPNRTBM1	7.3
Autonomic ganglia	KPNSI9S	6.6
Autonomic ganglia	KPNYN	7.5
Autonomic ganglia	MHHNB11	7.6
Autonomic ganglia	NB1	8.1
Autonomic ganglia	NH6	6.9
Autonomic ganglia	SHSY5Y	7.8
Autonomic ganglia	SIMA	8
Autonomic ganglia	SKNAS	7
Autonomic ganglia	SKNBE2	7.2
Autonomic ganglia	SKNDZ	7.9
Autonomic ganglia	SKNFI	8.1
Autonomic ganglia	SKNSH	6.9
Biliary tract	HUCCT1	6.9
Biliary tract	HUH28	6.8
Biliary tract	SNU1079	7.3
Biliary tract	SNU1196	6.5
Biliary tract	SNU245	6.8
Biliary tract	SNU308	6.8
Biliary tract	SNU478	6.6
Bone	143B	6.9
Bone	A673	7.3
Bone	CADOES1	7.4
Bone	CAL78	7.3
Bone	G292CLONEA141B1	7.5
Bone	HOS	6.6
Bone	HS706T	6.6
Bone	HS737T	6.9
Bone	HS819T	7
Bone	HS821T	7
Bone	HS822T	7
Bone	HS863T	7.1
Bone	HS870T	6.8
Bone	HS888T	7.1
Bone	MG63	7.1
Bone	MHHES1	8.2
Bone	OUMS27	7.4
Bone	RDES	7.8
Bone	SJSA1	7.5
Bone	SKES1	7.7
Bone	SKNMC	7.6
Bone	SW1353	6.9
Bone	T173	6.6
Bone	TC71	6.4
Bone	U2OS	7.1
Breast	AU565	7.1
Breast	BT20	6.7
Breast	BT474	6.6
Breast	BT483	7.6
Breast	BT549	6.5
Breast	CAL120	7.9
Breast	CAL148	7.4
Breast	CAL51	7.4
Breast	CAL851	6.3
Breast	CAMA1	6.2
Breast	DU4475	7.2
Breast	EFM192A	6.1
Breast	EFM19	6.6
Breast	EVSAT	6.6
Breast	HCC1143	6.6
Breast	HCC1187	8
Breast	HCC1395	7.2
Breast	HCC1419	7.4
Breast	HCC1428	8
Breast	HCC1500	7.6
Breast	HCC1569	6.7
Breast	HCC1599	6.4
Breast	HCC1806	7.3
Breast	HCC1937	7.7
Breast	HCC1954	7.1
Breast	HCC202	6.5
Breast	HCC2157	6
Breast	HCC2218	6.1
Breast	HCC38	6.6
Breast	HCC70	6.5
Breast	HDQP1	7.7
Breast	HMC18	6.7
Breast	HS274T	7.2
Breast	HS281T	7
Breast	HS343T	7
Breast	HS578T	6.7
Breast	HS606T	7
Breast	HS739T	7
Breast	HS742T	7
Breast	JIMT1	7.6
Breast	KPL1	6.6
Breast	MCF7	6.6
Breast	MDAMB134VI	7.5
Breast	MDAMB157	6
Breast	MDAMB175VII	6.8
Breast	MDAMB231	6.5
Breast	MDAMB361	7.3
Breast	MDAMB415	5.9
Breast	MDAMB436	7.5
Breast	MDAMB453	6.8
Breast	MDAMB468	6.2
Breast	SKBR3	7.2
Breast	T47D	6.4
Breast	UACC812	6.4
Breast	UACC893	7
Breast	YMB1	7.5
Breast	ZR751	7.4
Breast	ZR7530	7.5
Central nervous system	1321N1	6.6
Central nervous system	42MGBA	7
Central nervous system	8MGBA	6.8
Central nervous system	A172	6.4
Central nervous system	AM38	6.5
Central nervous system	BECKER	6.9
Central nervous system	CAS1	6.8
Central nervous system	CCFSTTG1	6.6
Central nervous system	D283MED	7.7
Central nervous system	D341MED	7.8
Central nervous system	DAOY	6.7
Central nervous system	DBTRG05MG	7
Central nervous system	DKMG	7.3
Central nervous system	GAMG	6.7
Central nervous system	GB1	7.1
Central nervous system	GI1	6.8
Central nervous system	GMS10	6.4
Central nervous system	GOS3	7.3
Central nervous system	H4	7.2
Central nervous system	HS683	7
Central nervous system	KALS1	7.5
Central nervous system	KG1C	7
Central nervous system	KNS42	7.2
Central nervous system	KNS60	7
Central nervous system	KNS81	7.2
Central nervous system	KS1	6.9
Central nervous system	LN18	6.8
Central nervous system	LN229	7.1
Central nervous system	M059K	6.4
Central nervous system	MOGGCCM	6.5
Central nervous system	MOGGUVW	6.9
Central nervous system	NMCG1	6.6
Central nervous system	ONS76	6.7
Central nervous system	SF126	6.8
Central nervous system	SF295	6.6
Central nervous system	SNB19	6.3
Central nervous system	SNU1105	7
Central nervous system	SNU201	7.3
Central nervous system	SNU466	7.5
Central nervous system	SNU489	7
Central nervous system	SNU626	6.9
Central nervous system	SNU738	7.4
Central nervous system	SW1088	6.8
Central nervous system	SW1783	6.6
Central nervous system	T98G	7.4
Central nervous system	TM31	7.7
Central nervous system	U118MG	7.1
Central nervous system	U138MG	6.9
Central nervous system	U251MG	6.5
Central nervous system	U87MG	6.9
Central nervous system	YH13	7.2
Central nervous system	YKG1	7.5
Endometrium	AN3CA	6.5
Endometrium	COLO684	6.5
Endometrium	EFE184	6.6
Endometrium	EN	6.4
Endometrium	ESS1	7.5
Endometrium	HEC108	7
Endometrium	HEC151	6.3
Endometrium	HEC1A	7
Endometrium	HEC1B	7.4
Endometrium	HEC251	7.3
Endometrium	HEC265	6.5
Endometrium	HEC50B	5.6
Endometrium	HEC59	6.6
Endometrium	HEC6	5.4
Endometrium	ISHIKAWAHERAKLIO02ER	7.5
Endometrium	JHUEM1	6.2
Endometrium	JHUEM2	7.1
Endometrium	JHUEM3	6.7
Endometrium	KLE	6.1
Endometrium	MFE280	6.5
Endometrium	MFE296	7
Endometrium	MFE319	6.1
Endometrium	RL952	7
Endometrium	SNGM	6.9
Endometrium	SNU1077	7.2
Endometrium	SNU685	7.8
Endometrium	TEN	7.2
Haematopoietic and lymphoid	697	8.2
Haematopoietic and lymphoid	A3KAW	6.8
Haematopoietic and lymphoid	A4FUK	7.9
Haematopoietic and lymphoid	ALLSIL	8.5
Haematopoietic and lymphoid	AML193	7.6
Haematopoietic and lymphoid	AMO1	8
Haematopoietic and lymphoid	BCP1	8.4
Haematopoietic and lymphoid	BDCM	7
Haematopoietic and lymphoid	BL41	7.9
Haematopoietic and lymphoid	BL70	7.7
Haematopoietic and lymphoid	BV173	7.9
Haematopoietic and lymphoid	CA46	7.9
Haematopoietic and lymphoid	CI1	7.4
Haematopoietic and lymphoid	CMK115	6.8
Haematopoietic and lymphoid	CMK86	7
Haematopoietic and lymphoid	CMK	6.9
Haematopoietic and lymphoid	CMLT1	8
Haematopoietic and lymphoid	COLO775	6.7
Haematopoietic and lymphoid	DAUDI	7.4
Haematopoietic and lymphoid	DB	7.7
Haematopoietic and lymphoid	DEL	7.8
Haematopoietic and lymphoid	DND41	7.9
Haematopoietic and lymphoid	DOHH2	8.1
Haematopoietic and lymphoid	EB1	7.6
Haematopoietic and lymphoid	EB2	7.2
Haematopoietic and lymphoid	EHEB	7.4
Haematopoietic and lymphoid	EJM	6.5
Haematopoietic and lymphoid	EM2	7.9
Haematopoietic and lymphoid	EOL1	8.3
Haematopoietic and lymphoid	F36P	7.4
Haematopoietic and lymphoid	GA10	7.8
Haematopoietic and lymphoid	GDM1	7.5
Haematopoietic and lymphoid	GRANTA519	8.1
Haematopoietic and lymphoid	HDLM2	8.3
Haematopoietic and lymphoid	HDMYZ	6.6
Haematopoietic and lymphoid	HEL9217	7.2
Haematopoietic and lymphoid	HEL	7.9
Haematopoietic and lymphoid	HH	7.5
Haematopoietic and lymphoid	HL60	8.3
Haematopoietic and lymphoid	HPBALL	7.5
Haematopoietic and lymphoid	HS604T	7.4
Haematopoietic and lymphoid	HS611T	7.4
Haematopoietic and lymphoid	HS616T	6.9
Haematopoietic and lymphoid	HS751T	6.9
Haematopoietic and lymphoid	HT	7.5
Haematopoietic and lymphoid	HTK	6.8
Haematopoietic and lymphoid	HUNS1	7.1
Haematopoietic and lymphoid	HUT102	7.5
Haematopoietic and lymphoid	HUT78	7.3
Haematopoietic and lymphoid	JEKO1	7.9
Haematopoietic and lymphoid	JK1	7.3
Haematopoietic and lymphoid	JM1	7.8
Haematopoietic and lymphoid	JURKAT	8
Haematopoietic and lymphoid	JURLMK1	7.5
Haematopoietic and lymphoid	JVM2	7.9
Haematopoietic and lymphoid	JVM3	8.7
Haematopoietic and lymphoid	K562	6.6
Haematopoietic and lymphoid	KARPAS299	8.4
Haematopoietic and lymphoid	KARPAS422	7.9
Haematopoietic and lymphoid	KARPAS620	7.9
Haematopoietic and lymphoid	KASUMI1	8.1
Haematopoietic and lymphoid	KASUMI2	7.8
Haematopoietic and lymphoid	KASUMI6	6.9
Haematopoietic and lymphoid	KCL22	7.1
Haematopoietic and lymphoid	KE37	8.1
Haematopoietic and lymphoid	KE97	7.2
Haematopoietic and lymphoid	KG1	7.3
Haematopoietic and lymphoid	KHM1B	6.8
Haematopoietic and lymphoid	KIJK	7.3
Haematopoietic and lymphoid	KMH2	8
Haematopoietic and lymphoid	KMM1	7.1
Haematopoietic and lymphoid	KMS11	7.6
Haematopoietic and lymphoid	KMS12BM	7.7
Haematopoietic and lymphoid	KMS18	7.8
Haematopoietic and lymphoid	KMS20	7.3
Haematopoietic and lymphoid	KMS21BM	6.4
Haematopoietic and lymphoid	KMS26	7.2
Haematopoietic and lymphoid	KMS27	7
Haematopoietic and lymphoid	KMS28BM	6.5
Haematopoietic and lymphoid	KMS34	7.5
Haematopoietic and lymphoid	KO52	8
Haematopoietic and lymphoid	KOPN8	7.2
Haematopoietic and lymphoid	KU812	7.6
Haematopoietic and lymphoid	KYO1	6.4
Haematopoietic and lymphoid	L1236	7.8
Haematopoietic and lymphoid	L363	8.1
Haematopoietic and lymphoid	L428	8.4
Haematopoietic and lymphoid	L540	7.7
Haematopoietic and lymphoid	LAMA84	7.6
Haematopoietic and lymphoid	LOUCY	8.5
Haematopoietic and lymphoid	LP1	6.9
Haematopoietic and lymphoid	M07E	8.3
Haematopoietic and lymphoid	MC116	7.6
Haematopoietic and lymphoid	ME1	7.2
Haematopoietic and lymphoid	MEC1	8.3
Haematopoietic and lymphoid	MEC2	8.3
Haematopoietic and lymphoid	MEG01	7.2
Haematopoietic and lymphoid	MHHCALL2	8.8
Haematopoietic and lymphoid	MHHCALL3	8.6
Haematopoietic and lymphoid	MHHCALL4	7.7
Haematopoietic and lymphoid	MINO	7.8
Haematopoietic and lymphoid	MJ	7.1
Haematopoietic and lymphoid	MM1S	7.2
Haematopoietic and lymphoid	MOLM13	7.7
Haematopoietic and lymphoid	MOLM16	7.9
Haematopoietic and lymphoid	MOLM6	7.5
Haematopoietic and lymphoid	MOLP2	8.1
Haematopoietic and lymphoid	MOLP8	7.9
Haematopoietic and lymphoid	MOLT13	8.5
Haematopoietic and lymphoid	MOLT16	8.6
Haematopoietic and lymphoid	MOLT4	7.6
Haematopoietic and lymphoid	MONOMAC1	7.8
Haematopoietic and lymphoid	MONOMAC6	6.4
Haematopoietic and lymphoid	MOTN1	8.1
Haematopoietic and lymphoid	MUTZ5	8.3
Haematopoietic and lymphoid	MV411	8.1
Haematopoietic and lymphoid	NALM19	8.6
Haematopoietic and lymphoid	NALM1	8.6
Haematopoietic and lymphoid	NALM6	7.9
Haematopoietic and lymphoid	NAMALWA	8.2
Haematopoietic and lymphoid	NB4	7.9
Haematopoietic and lymphoid	NCIH929	6.8
Haematopoietic and lymphoid	NCO2	7.5
Haematopoietic and lymphoid	NOMO1	8.3
Haematopoietic and lymphoid	NUDHL1	8
Haematopoietic and lymphoid	NUDUL1	8.5
Haematopoietic and lymphoid	OCIAML2	7.7
Haematopoietic and lymphoid	OCIAML3	8
Haematopoietic and lymphoid	OCIAML5	7.6
Haematopoietic and lymphoid	OCILY10	7.4
Haematopoietic and lymphoid	OCILY19	8.5
Haematopoietic and lymphoid	OCILY3	7.3
Haematopoietic and lymphoid	OCIM1	7.9
Haematopoietic and lymphoid	OPM2	8.2
Haematopoietic and lymphoid	P12ICHIKAWA	7.8
Haematopoietic and lymphoid	P31FUJ	7
Haematopoietic and lymphoid	P3HR1	7.7
Haematopoietic and lymphoid	PCM6	7.4
Haematopoietic and lymphoid	PEER	7.8
Haematopoietic and lymphoid	PF382	8.3
Haematopoietic and lymphoid	PFEIFFER	7.8
Haematopoietic and lymphoid	PL21	8.7
Haematopoietic and lymphoid	RAJI	7.4
Haematopoietic and lymphoid	RCHACV	8.3
Haematopoietic and lymphoid	REC1	7.2
Haematopoietic and lymphoid	REH	7.1
Haematopoietic and lymphoid	RI1	7.8
Haematopoietic and lymphoid	RL	7.8
Haematopoietic and lymphoid	RPMI8226	6.9
Haematopoietic and lymphoid	RPMI8402	8.6
Haematopoietic and lymphoid	RS411	7.9
Haematopoietic and lymphoid	SEM	7.4
Haematopoietic and lymphoid	SET2	7.7
Haematopoietic and lymphoid	SIGM5	8.3
Haematopoietic and lymphoid	SKM1	6.6
Haematopoietic and lymphoid	SKMM2	7.3
Haematopoietic and lymphoid	SR786	8.1
Haematopoietic and lymphoid	ST486	7.8
Haematopoietic and lymphoid	SUDHL10	7.4
Haematopoietic and lymphoid	SUDHL1	8.1
Haematopoietic and lymphoid	SUDHL4	8.3
Haematopoietic and lymphoid	SUDHL5	8.6
Haematopoietic and lymphoid	SUDHL6	7.9
Haematopoietic and lymphoid	SUDHL8	8.4
Haematopoietic and lymphoid	SUPB15	7.8
Haematopoietic and lymphoid	SUPHD1	7.5
Haematopoietic and lymphoid	SUPM2	7.5
Haematopoietic and lymphoid	SUPT11	7.4
Haematopoietic and lymphoid	SUPT1	7.6
Haematopoietic and lymphoid	TALL1	8.2
Haematopoietic and lymphoid	TF1	7.1
Haematopoietic and lymphoid	THP1	6.3
Haematopoietic and lymphoid	TO175T	6.9
Haematopoietic and lymphoid	TOLEDO	8.4
Haematopoietic and lymphoid	U266B1	6.2
Haematopoietic and lymphoid	U937	7.2
Haematopoietic and lymphoid	UT7	7.6
Haematopoietic and lymphoid	WSUDLCL2	7.7
Kidney	769P	6.8
Kidney	786O	6.5
Kidney	A498	7.2
Kidney	A704	7
Kidney	ACHN	7.2
Kidney	BFTC909	7.8
Kidney	CAKI1	6.9
Kidney	CAKI2	6.8
Kidney	CAL54	7.4
Kidney	KMRC1	7.3
Kidney	KMRC20	6.7
Kidney	KMRC2	7
Kidney	KMRC3	6.9
Kidney	OSRC2	7.2
Kidney	RCC10RGB	7.4
Kidney	SNU1272	7
Kidney	SNU349	7.3
Kidney	TUHR10TKB	6.8
Kidney	TUHR14TKB	7.2
Kidney	TUHR4TKB	7.4
Kidney	VMRCRCW	6.5
Kidney	VMRCRCZ	7.1
Large intestine	C2BBE1	6.8
Large intestine	CCK81	6.5
Large intestine	CL11	6.3
Large intestine	CL14	6.9
Large intestine	CL34	6.9
Large intestine	CL40	7.4
Large intestine	COLO205	6.7
Large intestine	COLO320	8.2
Large intestine	COLO678	8
Large intestine	CW2	6.8
Large intestine	DLD1	6.2
Large intestine	GP2D	6.8
Large intestine	HCC56	7.3
Large intestine	HCT116	6.2
Large intestine	HCT15	6.7
Large intestine	HS675T	6.7
Large intestine	HS698T	6.9
Large intestine	HT115	6.3
Large intestine	HT29	6.7
Large intestine	HT55	7.3
Large intestine	KM12	6.5
Large intestine	LOVO	6.8
Large intestine	LS1034	8
Large intestine	LS123	7.8
Large intestine	LS180	6.6
Large intestine	LS411N	6.8
Large intestine	LS513	6.7
Large intestine	MDST8	6.9
Large intestine	NCIH508	6.8
Large intestine	NCIH716	7.2
Large intestine	NCIH747	6.2
Large intestine	OUMS23	7.4
Large intestine	RCM1	6.9
Large intestine	RKO	6.7
Large intestine	SKCO1	7
Large intestine	SNU1040	6.7
Large intestine	SNU1197	5.7
Large intestine	SNU175	6.5
Large intestine	SNU283	7.1
Large intestine	SNU407	6.9
Large intestine	SNU503	7.7
Large intestine	SNU61	6.8
Large intestine	SNU81	7.2
Large intestine	SNUC1	6.7
Large intestine	SNUC2A	6.7
Large intestine	SNUC4	6.3
Large intestine	SNUC5	6.7
Large intestine	SW1116	6.8
Large intestine	SW1417	6.4
Large intestine	SW1463	7.2
Large intestine	SW403	6.5
Large intestine	SW480	6.9
Large intestine	SW48	6.5
Large intestine	SW620	7.6
Large intestine	SW837	7.1
Large intestine	SW948	6.9
Large intestine	T84	7.3
Liver	ALEXANDERCELLS	6.4
Liver	C3A	6.8
Liver	HEP3B217	8
Liver	HEPG2	7.1
Liver	HLE	7.2
Liver	HLF	6.9
Liver	HUH1	6.3
Liver	HUH6	7.1
Liver	HUH7	7.1
Liver	JHH1	7.5
Liver	JHH2	6.5
Liver	JHH4	7
Liver	JHH5	6.9
Liver	JHH6	7.4
Liver	JHH7	7
Liver	LI7	7.3
Liver	PLCPRF5	6.7
Liver	SKHEP1	7.7
Liver	SNU182	6.7
Liver	SNU387	7.2
Liver	SNU398	7.5
Liver	SNU423	6.5
Liver	SNU449	6.7
Liver	SNU475	6.6
Liver	SNU761	7.3
Liver	SNU878	6.3
Liver	SNU886	6.9
Lung	A549	6.9
Lung	ABC1	6.3
Lung	BEN	7.7
Lung	CAL12T	6.5
Lung	CALU1	7.1
Lung	CALU3	6.9
Lung	CALU6	7.7
Lung	CHAGOK1	7
Lung	COLO668	7.9
Lung	COLO699	6.8
Lung	CORL105	7.3
Lung	CORL23	6.4
Lung	CORL24	8
Lung	CORL279	7
Lung	CORL311	6.7
Lung	CORL47	6.7
Lung	CORL51	7.6
Lung	CORL88	8.5
Lung	CORL95	7.4
Lung	CPCN	6.9
Lung	DMS114	7.1
Lung	DMS153	7.2
Lung	DMS273	6.8
Lung	DMS454	7
Lung	DMS53	7.5
Lung	DMS79	7.2
Lung	DV90	5.7
Lung	EBC1	7.2
Lung	EPLC272H	7
Lung	HARA	6.6
Lung	HCC1171	7.2
Lung	HCC1195	7
Lung	HCC15	6.9
Lung	HCC2279	7.3
Lung	HCC2935	7.1
Lung	HCC33	8.8
Lung	HCC366	7
Lung	HCC4006	6.8
Lung	HCC44	6.6
Lung	HCC78	6.8
Lung	HCC827	7.2
Lung	HCC95	7.7
Lung	HLC1	7
Lung	HLFA	6.8
Lung	HS229T	6.5
Lung	HS618T	6.4
Lung	IALM	8.9
Lung	KNS62	6.3
Lung	LC1F	6.8
Lung	LC1SQSF	7.7
Lung	LCLC103H	7.2
Lung	LCLC97TM1	8.2
Lung	LK2	7.3
Lung	LOUNH91	6.9
Lung	LU65	6.5
Lung	LU99	6.7
Lung	LUDLU1	6.9
Lung	LXF289	7.2
Lung	MORCPR	6.9
Lung	NCIH1048	7.2
Lung	NCIH1092	8.2
Lung	NCIH1105	8.4
Lung	NCIH1155	6.7
Lung	NCIH1184	7.4
Lung	NCIH1299	7
Lung	NCIH1339	7.3
Lung	NCIH1341	6.8
Lung	NCIH1355	6.5
Lung	NCIH1373	6.3
Lung	NCIH1385	7.7
Lung	NCIH1395	5.9
Lung	NCIH1435	6.8
Lung	NCIH1436	7.9
Lung	NCIH1437	6.3
Lung	NCIH146	7.1
Lung	NCIH1563	7.1
Lung	NCIH1568	7
Lung	NCIH1573	7
Lung	NCIH1581	6.8
Lung	NCIH1618	7.6
Lung	NCIH1623	8
Lung	NCIH1648	6.9
Lung	NCIH1650	7
Lung	NCIH1651	7.7
Lung	NCIH1666	6.6
Lung	NCIH1693	6.3
Lung	NCIH1694	7.6
Lung	NCIH1703	7.3
Lung	NCIH1734	6.4
Lung	NCIH1755	6.1
Lung	NCIH1781	6.6
Lung	NCIH1792	6.5
Lung	NCIH1793	6.2
Lung	NCIH1836	7.9
Lung	NCIH1838	5.7
Lung	NCIH1869	6.9
Lung	NCIH1876	9.1
Lung	NCIH1915	6.7
Lung	NCIH1930	7.8
Lung	NCIH1944	7.2
Lung	NCIH1963	7.7
Lung	NCIH196	7.6
Lung	NCIH1975	6.5
Lung	NCIH2009	6.8
Lung	NCIH2023	6.8
Lung	NCIH2029	7.7
Lung	NCIH2030	6.2
Lung	NCIH2066	7.2
Lung	NCIH2081	7.7
Lung	NCIH2085	6.7
Lung	NCIH2087	6.3
Lung	NCIH209	7.3
Lung	NCIH2106	6.7
Lung	NCIH2110	7.5
Lung	NCIH211	7.4
Lung	NCIH2122	6.5
Lung	NCIH2126	6.4
Lung	NCIH2141	8.9
Lung	NCIH2170	7.1
Lung	NCIH2171	8.3
Lung	NCIH2172	6.4
Lung	NCIH2196	6.3
Lung	NCIH2227	6.3
Lung	NCIH2228	6.7
Lung	NCIH226	7.2
Lung	NCIH2286	7.5
Lung	NCIH2291	6.5
Lung	NCIH2342	6.2
Lung	NCIH2347	6.3
Lung	NCIH23	7.1
Lung	NCIH2405	7.2
Lung	NCIH2444	7.3
Lung	NCIH292	6.7
Lung	NCIH322	6.8
Lung	NCIH3255	6.9
Lung	NCIH358	6.1
Lung	NCIH441	6.9
Lung	NCIH446	7.1
Lung	NCIH460	6.7
Lung	NCIH510	7.3
Lung	NCIH520	7
Lung	NCIH522	7.1
Lung	NCIH524	7
Lung	NCIH526	6.8
Lung	NCIH596	6.4
Lung	NCIH647	7
Lung	NCIH650	8.4
Lung	NCIH661	6.7
Lung	NCIH69	6.7
Lung	NCIH727	7.7
Lung	NCIH810	7.6
Lung	NCIH82	7.7
Lung	NCIH838	6.6
Lung	NCIH841	7.4
Lung	NCIH854	7.5
Lung	NCIH889	7.7
Lung	PC14	7
Lung	RERFLCAD1	7.2
Lung	RERFLCAD2	7
Lung	RERFLCAI	6.3
Lung	RERFLCKJ	7.1
Lung	RERFLCMS	5.9
Lung	RERFLCSQ1	6.7
Lung	SBC5	6.9
Lung	SCLC21H	6.5
Lung	SHP77	6.5
Lung	SKLU1	7.5
Lung	SKMES1	6.4
Lung	SQ1	5.9
Lung	SW1271	7.6
Lung	SW1573	7.7
Lung	SW900	6.7
Lung	VMRCLCD	7.3
Lung	VMRCLCP	7.2
Oesophagus	COLO680N	7.2
Oesophagus	ECGI10	7.6
Oesophagus	KYSE140	7.1
Oesophagus	KYSE150	7.1
Oesophagus	KYSE180	6.6
Oesophagus	KYSE270	7.5
Oesophagus	KYSE30	7.6
Oesophagus	KYSE410	6.9
Oesophagus	KYSE450	7.3
Oesophagus	KYSE510	6.8
Oesophagus	KYSE520	7.1
Oesophagus	KYSE70	6.9
Oesophagus	OE19	6.5
Oesophagus	OE33	7.1
Oesophagus	TE10	7.1
Oesophagus	TE11	6.7
Oesophagus	TE14	6.8
Oesophagus	TE15	6.3
Oesophagus	TE1	5.8
Oesophagus	TE4	6.7
Oesophagus	TE5	7.6
Oesophagus	TE6	7.8
Oesophagus	TE8	7.7
Oesophagus	TE9	7.1
Oesophagus	TT	7.6
Ovary	59M	7.2
Ovary	A2780	7.2
Ovary	CAOV3	7.7
Ovary	CAOV4	8
Ovary	COLO704	6.7
Ovary	COV318	7
Ovary	COV362	7.1
Ovary	COV434	7.4
Ovary	COV504	6.9
Ovary	COV644	7.4
Ovary	EFO21	5.3
Ovary	EFO27	6.8
Ovary	ES2	6.7
Ovary	FUOV1	8
Ovary	HEYA8	7.5
Ovary	HS571T	7
Ovary	IGROV1	6.6
Ovary	JHOC5	6.9
Ovary	JHOM1	8.1
Ovary	JHOM2B	8.2
Ovary	JHOS2	7.9
Ovary	JHOS4	6.8
Ovary	KURAMOCHI	6.9
Ovary	MCAS	6.6
Ovary	NIHOVCAR3	6.9
Ovary	OAW28	7.8
Ovary	OAW42	6.8
Ovary	OC314	6.3
Ovary	OC316	6.2
Ovary	ONCODG1	7
Ovary	OV56	6.7
Ovary	OV7	6.3
Ovary	OV90	7.4
Ovary	OVCAR4	6.7
Ovary	OVCAR8	7.2
Ovary	OVISE	7.3
Ovary	OVK18	5.3
Ovary	OVKATE	6.2
Ovary	OVMANA	8
Ovary	OVSAHO	6.3
Ovary	OVTOKO	7
Ovary	RMGI	6.6
Ovary	RMUGS	6.3
Ovary	SKOV3	6.3
Ovary	SNU119	8
Ovary	SNU840	7
Ovary	SNU8	7
Ovary	TOV112D	7.2
Ovary	TOV21G	6.3
Ovary	TYKNU	6.5
Pancreas	ASPC1	6.8
Pancreas	BXPC3	6.6
Pancreas	CAPAN1	7
Pancreas	CAPAN2	7
Pancreas	CFPAC1	6.5
Pancreas	DANG	6.6
Pancreas	HPAC	8.2
Pancreas	HPAFII	6.5
Pancreas	HS766T	6.3
Pancreas	HUPT3	6.6
Pancreas	HUPT4	6.9
Pancreas	KCIMOH1	7.5
Pancreas	KLM1	7
Pancreas	KP2	7.5
Pancreas	KP3	7
Pancreas	KP4	8.3
Pancreas	L33	6.8
Pancreas	MIAPACA2	8.1
Pancreas	PANC0203	6.8
Pancreas	PANC0213	6.9
Pancreas	PANC0327	7.2
Pancreas	PANC0403	6.7
Pancreas	PANC0504	6.9
Pancreas	PANC0813	7.1
Pancreas	PANC1005	6.9
Pancreas	PANC1	6.2
Pancreas	PATU8902	9
Pancreas	PATU8988S	6.2
Pancreas	PATU8988T	6.2
Pancreas	PK1	6.3
Pancreas	PK45H	7.6
Pancreas	PK59	6.4
Pancreas	PL45	6.6
Pancreas	PSN1	7
Pancreas	QGP1	7.2
Pancreas	SNU213	6.5
Pancreas	SNU324	7.3
Pancreas	SNU410	7.1
Pancreas	SU8686	7.9
Pancreas	SUIT2	7.3
Pancreas	SW1990	7.1
Pancreas	T3M4	6.3
Pancreas	TCCPAN2	6.3
Pancreas	YAPC	6.9
Pleura	ACCMESO1	6.7
Pleura	DM3	6.7
Pleura	ISTMES1	6.9
Pleura	ISTMES2	6.8
Pleura	JL1	7.5
Pleura	MPP89	6.7
Pleura	MSTO211H	7.2
Pleura	NCIH2052	7
Pleura	NCIH2452	7.2
Pleura	NCIH28	6.9
Prostate	22RV1	6.9
Prostate	DU145	6.1
Prostate	LNCAPCLONEFGC	6.9
Prostate	MDAPCA2B	6.5
Prostate	NCIH660	6.6
Prostate	PC3	6
Prostate	VCAP	7.1
Salivary gland	A253	6.8
Salivary gland	YD15	6.6
Skin	A101D	7.1
Skin	A2058	6.9
Skin	A375	6.9
Skin	C32	6.7
Skin	CHL1	7.3
Skin	CJM	7.2
Skin	COLO679	7.2
Skin	COLO741	6.7
Skin	COLO783	7.5
Skin	COLO792	6.5
Skin	COLO800	7
Skin	COLO818	7.2
Skin	COLO829	7.1
Skin	COLO849	6.9
Skin	G361	6.5
Skin	GRM	6.6
Skin	HMCB	7.2
Skin	HS294T	7.4
Skin	HS600T	6.7
Skin	HS688AT	6.8
Skin	HS695T	7
Skin	HS839T	6.4
Skin	HS852T	7
Skin	HS895T	6.5
Skin	HS934T	7
Skin	HS936T	6.8
Skin	HS939T	6.5
Skin	HS940T	6.8
Skin	HS944T	6.1
Skin	HT144	6.9
Skin	IGR1	8
Skin	IGR37	6.6
Skin	IGR39	7.7
Skin	IPC298	6.8
Skin	K029AX	6.6
Skin	LOXIMVI	7
Skin	MALME3M	6.8
Skin	MDAMB435S	7
Skin	MELHO	6.5
Skin	MELJUSO	6.9
Skin	MEWO	6.4
Skin	RPMI7951	7
Skin	RVH421	6.8
Skin	SH4	6.5
Skin	SKMEL1	8.7
Skin	SKMEL24	7.2
Skin	SKMEL28	6.7
Skin	SKMEL2	6.3
Skin	SKMEL30	6.8
Skin	SKMEL31	8.2
Skin	SKMEL3	7
Skin	SKMEL5	6.6
Skin	UACC257	6.3
Skin	UACC62	6.5
Skin	WM115	7.2
Skin	WM1799	7.3
Skin	WM2664	6.3
Skin	WM793	7.2
Skin	WM88	7.5
Skin	WM983B	7.5
Small intestine	HUTU80	7.3
Soft tissue	A204	6.8
Soft tissue	G401	7.1
Soft tissue	G402	6.3
Soft tissue	GCT	7.1
Soft tissue	HS729	6.7
Soft tissue	HT1080	6.9
Soft tissue	KYM1	7.5
Soft tissue	MESSA	7.2
Soft tissue	RD	7.2
Soft tissue	RH30	8
Soft tissue	RH41	7
Soft tissue	RKN	7.4
Soft tissue	S117	7
Soft tissue	SJRH30	7.9
Soft tissue	SKLMS1	6.5
Soft tissue	SKUT1	6.8
Soft tissue	TE125T	6.8
Soft tissue	TE159T	6.7
Soft tissue	TE441T	8.2
Soft tissue	TE617T	7.1
Stomach	2313287	6.8
Stomach	AGS	6.9
Stomach	AZ521	7.4
Stomach	ECC10	7.5
Stomach	ECC12	7.2
Stomach	FU97	7.5
Stomach	GCIY	6.1
Stomach	GSS	6.8
Stomach	GSU	7.4
Stomach	HGC27	6.4
Stomach	HS746T	6.7
Stomach	HUG1N	6.7
Stomach	IM95	5.8
Stomach	KATOIII	6.1
Stomach	KE39	6.9
Stomach	LMSU	6.4
Stomach	MKN1	6.4
Stomach	MKN45	8.7
Stomach	MKN74	6.9
Stomach	MKN7	5.8
Stomach	NCCSTCK140	7.3
Stomach	NCIN87	7.2
Stomach	NUGC2	7.9
Stomach	NUGC3	6.5
Stomach	NUGC4	6.7
Stomach	OCUM1	6.9
Stomach	RERFGC1B	7
Stomach	SH10TC	7.5
Stomach	SNU16	6.4
Stomach	SNU1	7
Stomach	SNU216	6.8
Stomach	SNU520	6.5
Stomach	SNU5	6.6
Stomach	SNU601	7
Stomach	SNU620	6.9
Stomach	SNU668	6.9
Stomach	SNU719	7.1
Stomach	TGBC11TKB	7.9
Thyroid	8305C	6.6
Thyroid	8505C	7.3
Thyroid	BCPAP	7.8
Thyroid	BHT101	7.6
Thyroid	CAL62	7.7
Thyroid	CGTHW1	7.3
Thyroid	FTC133	6.5
Thyroid	FTC238	6.8
Thyroid	ML1	7.7
Thyroid	SW579	7
Thyroid	TT2609C02	7.1
Thyroid	TT	7.2
Upper aerodigestive tract	BHY	7
Upper aerodigestive tract	BICR16	6.7
Upper aerodigestive tract	BICR18	6.9
Upper aerodigestive tract	BICR22	7.5
Upper aerodigestive tract	BICR31	7.2
Upper aerodigestive tract	BICR56	7.1
Upper aerodigestive tract	BICR6	7.3
Upper aerodigestive tract	CAL27	7.2
Upper aerodigestive tract	CAL33	7.1
Upper aerodigestive tract	DETROIT562	7
Upper aerodigestive tract	FADU	8.3
Upper aerodigestive tract	HS840T	6.5
Upper aerodigestive tract	HSC2	7.4
Upper aerodigestive tract	HSC3	7
Upper aerodigestive tract	HSC4	7.4
Upper aerodigestive tract	PECAPJ15	7.2
Upper aerodigestive tract	PECAPJ34CLONEC12	6.8
Upper aerodigestive tract	PECAPJ41CLONED2	6.7
Upper aerodigestive tract	PECAPJ49	6.9
Upper aerodigestive tract	SCC15	7.3
Upper aerodigestive tract	SCC25	7
Upper aerodigestive tract	SCC4	7.1
Upper aerodigestive tract	SCC9	6.5
Upper aerodigestive tract	SNU1076	7.8
Upper aerodigestive tract	SNU1214	7.1
Upper aerodigestive tract	SNU46	7.3
Upper aerodigestive tract	SNU899	7.2
Upper aerodigestive tract	YD10B	8.2
Upper aerodigestive tract	YD38	7.1
Upper aerodigestive tract	YD8	7.8
Urinary tract	5637	6.1
Urinary tract	639V	7.8
Urinary tract	647V	7.5
Urinary tract	BC3C	6.9
Urinary tract	BFTC905	7.5
Urinary tract	CAL29	7.6
Urinary tract	HS172T	6.9
Urinary tract	HT1197	7.3
Urinary tract	HT1376	6.8
Urinary tract	J82	6.6
Urinary tract	JMSU1	7.7
Urinary tract	KMBC2	7.1
Urinary tract	KU1919	7.7
Urinary tract	RT11284	7.4
Urinary tract	RT112	6.9
Urinary tract	RT4	7.1
Urinary tract	SCABER	6.7
Urinary tract	SW1710	6.9
Urinary tract	SW780	7.1
Urinary tract	T24	7
Urinary tract	TCCSUP	6.5
Urinary tract	UMUC1	6.5
Urinary tract	UMUC3	7.4
Urinary tract	VMCUB1	7.3

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	10.5
Adrenal gland	13.3
Appendix	18.2
Bone marrow	31.1
Breast	14.3
Cerebral cortex	9.3
Cervix, uterine	15.5
Colon	9.4
Duodenum	8.5
Endometrium	18
Epididymis	9.7
Esophagus	10.5
Fallopian tube	13.7
Gallbladder	14.9
Heart muscle	3.9
Kidney	9.9
Liver	6.2
Lung	15.2
Lymph node	21
Ovary	15.1
Pancreas	2.1
Parathyroid gland	26
Placenta	18.8
Prostate	14.8
Rectum	12.6
Salivary gland	3.2
Seminal vesicle	11.3
Skeletal muscle	1.8
Skin	16
Small intestine	9.8
Smooth muscle	15.4
Spleen	21.7
Stomach	9.1
Testis	42.5
Thyroid gland	17.2
Tonsil	16.2
Urinary bladder	12.9

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
27548814	Overexpression	Neuroendocrine Neoplasm	We measured RBP2 mRNA and protein levels in enteropancreatic NETs by measuring RBP2 in matched human normal and NET tissue samples. RBP2 was overexpressed relative to tissue-matched normal controls in 80% of the human tumors measured.
26841866	Overexpression	primary breast cancer	Finally, by immunohistochemical staining of primary breast tissue microarrays we find that EMSY/KDM5A/SIN3B complex subunits are frequently overexpressed in primary breast cancer cases in a correlative manner.
25575817	Underexpression	Chronic Myeloid Leukemia	In this study, we found that the histone H3 lysine 4 (H3K4) demethylase RBP2 (also called JARID1A and KDM5A) is underexpressed in CML-BP. The RBP2 histone demethylase stimulates leukemia cell differentiation and inhibits cell proliferation.
24200674	Overexpression	Prostatic Carcinoma	SMYD3, SUV39H2, PRMT6, KDM5A, and KDM6A were upregulated, whereas KMT2A-E (MLL1-5) and KDM4B were downregulated in PCa, compared with normal prostate tissues.
23922798	Overexpression	Hepatocellular Carcinoma	We analyzed gene expression in 20 specimens each of human HCC and normal liver tissue by quantitative real-time PCR and immunohistochemistry. The expression of RBP2 was stronger in cancerous than non-cancerous tissues, but that of its binding microRNA, Homo sapiens miR-212 (hsa-miR-212), showed an opposite pattern
23722541	Overexpression	Lung Carcinoma	RBP2 was overexpressed in human lung cancer tissues where its depletion impaired cell proliferation, motility, migration, invasion, and metastasis.
22937203	Overexpression (Copy Number Gain)	Breast Carcinoma	In the present study, we found that the KDM5A gene was significantly amplified and over-expressed in various human tumors, including breast cancer.
28714030	Overexpression	Ovarian Carcinoma	Compared with adjacent normal tissue, it was identified that KDM5A was highly expressed in ovarian cancer tissues.

Summary
Symbol	KDM5A
Name	lysine demethylase 5A
Aliases	RBBP2; JARID1A; retinoblastoma-binding protein 2; Jumonji, AT rich interactive domain 1A (RBBP2-like); jumon ......
Location	12p13.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.532	6.26e-31	13.4	54.2	32.4	Neutral
BRCA	Breast invasive carcinoma	1075	0.517	1.6e-74	13.2	60.7	26	Neutral
CESC	Cervical and endocervical cancers	292	0.646	6.25e-36	13.7	65.8	20.5	Neutral
COAD	Colon adenocarcinoma	449	0.532	3.43e-34	10.5	65.3	24.3	Neutral
ESCA	Esophageal carcinoma	183	0.633	7.14e-22	19.7	43.2	37.2	Gain
GBM	Glioblastoma multiforme	147	0.434	4e-08	8.8	78.9	12.2	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.508	4.58e-35	7	60.7	32.3	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.174	6.04e-05	1	75.6	23.4	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.287	7.26e-07	0.7	60.8	38.5	Gain
LAML	Acute Myeloid Leukemia	166	0.317	3.25e-05	2.4	97.6	0	Neutral
LGG	Brain Lower Grade Glioma	513	0.482	3.04e-31	5.3	82.5	12.3	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.436	2.46e-18	20.3	67.3	12.4	Neutral
LUAD	Lung adenocarcinoma	512	0.589	4.85e-49	24.2	46.9	28.9	Neutral
LUSC	Lung squamous cell carcinoma	498	0.653	9.37e-62	7.8	41.2	51	Gain
OV	Ovarian serous cystadenocarcinoma	300	0.73	3.9e-51	14.7	30	55.3	Gain
PAAD	Pancreatic adenocarcinoma	177	0.722	9.48e-30	11.9	66.7	21.5	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.185	0.0183	1.2	91.4	7.4	Neutral
PRAD	Prostate adenocarcinoma	491	0.381	2.01e-18	13.4	83.5	3.1	Neutral
READ	Rectum adenocarcinoma	164	0.375	7.44e-07	12.8	62.8	24.4	Neutral
SARC	Sarcoma	255	0.492	5.65e-17	27.8	51.8	20.4	Neutral
SKCM	Skin Cutaneous Melanoma	367	0.421	3.25e-17	16.1	64.9	19.1	Neutral
STAD	Stomach adenocarcinoma	413	0.621	1.8e-45	16.2	59.6	24.2	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.55	3.26e-13	0	3.3	96.7	Gain
THCA	Thyroid carcinoma	497	0.032	0.479	0.4	97	2.6	Neutral
THYM	Thymoma	119	0.251	0.00588	5.9	90.8	3.4	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.471	5.05e-31	7.1	76.7	16.2	Neutral

Summary
Symbol	KDM5A
Name	lysine demethylase 5A
Aliases	RBBP2; JARID1A; retinoblastoma-binding protein 2; Jumonji, AT rich interactive domain 1A (RBBP2-like); jumon ......
Location	12p13.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR [ TOP ]
There is no record.

Summary
Symbol	KDM5A
Name	lysine demethylase 5A
Aliases	RBBP2; JARID1A; retinoblastoma-binding protein 2; Jumonji, AT rich interactive domain 1A (RBBP2-like); jumon ......
Location	12p13.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA) [ TOP ]
There is no antibody staining data.

Summary
Symbol	KDM5A
Name	lysine demethylase 5A
Aliases	RBBP2; JARID1A; retinoblastoma-binding protein 2; Jumonji, AT rich interactive domain 1A (RBBP2-like); jumon ......
Location	12p13.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.501	NS	24476821
BRCA	Breast invasive carcinoma	521	1.3e-06	Significant	23000897
COAD	Colon adenocarcinoma	149	0.194	NS	22810696
GBM	Glioblastoma multiforme	157	0.00451	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	0.0247	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.0252	Significant	26536169
LGG	Brain Lower Grade Glioma	513	0.0311	Significant	26824661
LUAD	Lung adenocarcinoma	230	0.03	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	0.00828	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.00817	Significant	21720365
PRAD	Prostate adenocarcinoma	333	0.122	NS	26544944
READ	Rectum adenocarcinoma	67	0.144	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.537	NS	26091043
STAD	Stomach adenocarcinoma	277	0.104	NS	25079317
THCA	Thyroid carcinoma	391	0.00383	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.0821	NS	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	1.273	0.246	NS
BRCA	Breast invasive carcinoma	1079	1.103	0.679	NS
CESC	Cervical and endocervical cancers	291	1.387	0.329	NS
COAD	Colon adenocarcinoma	439	1.028	0.92	NS
ESCA	Esophageal carcinoma	184	1.487	0.23	NS
GBM	Glioblastoma multiforme	158	0.958	0.865	NS
HNSC	Head and Neck squamous cell carcinoma	518	1.137	0.516	NS
KIRC	Kidney renal clear cell carcinoma	531	0.548	0.00701	Longer
KIRP	Kidney renal papillary cell carcinoma	287	1.65	0.229	NS
LAML	Acute Myeloid Leukemia	149	0.819	0.501	NS
LGG	Brain Lower Grade Glioma	511	1.421	0.196	NS
LIHC	Liver hepatocellular carcinoma	365	0.909	0.697	NS
LUAD	Lung adenocarcinoma	502	1.183	0.41	NS
LUSC	Lung squamous cell carcinoma	494	0.974	0.892	NS
OV	Ovarian serous cystadenocarcinoma	303	1.665	0.0202	Shorter
PAAD	Pancreatic adenocarcinoma	177	1.615	0.101	NS
PCPG	Pheochromocytoma and Paraganglioma	179	0.99	0.992	NS
PRAD	Prostate adenocarcinoma	497	1.393	0.746	NS
READ	Rectum adenocarcinoma	159	0.666	0.431	NS
SARC	Sarcoma	259	1.394	0.228	NS
SKCM	Skin Cutaneous Melanoma	459	0.93	0.71	NS
STAD	Stomach adenocarcinoma	388	1.194	0.433	NS
TGCT	Testicular Germ Cell Tumors	134	0	0.309	NS
THCA	Thyroid carcinoma	500	1.185	0.824	NS
THYM	Thymoma	119	0	0.00297	Longer
UCEC	Uterine Corpus Endometrial Carcinoma	543	1.034	0.905	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	-0.007	0.893	NS
BRCA	Breast invasive carcinoma	1071	-0.007	0.824	NS
CESC	Cervical and endocervical cancers	167	0.075	0.336	NS
COAD	Colon adenocarcinoma	445	0.065	0.172	NS
ESCA	Esophageal carcinoma	162	0.059	0.457	NS
HNSC	Head and Neck squamous cell carcinoma	448	0.031	0.509	NS
KIRC	Kidney renal clear cell carcinoma	531	-0.029	0.511	NS
KIRP	Kidney renal papillary cell carcinoma	260	0.132	0.0335	Higher
LIHC	Liver hepatocellular carcinoma	347	0.003	0.953	NS
LUAD	Lung adenocarcinoma	507	0.109	0.0141	Higher
LUSC	Lung squamous cell carcinoma	497	-0.011	0.801	NS
OV	Ovarian serous cystadenocarcinoma	302	-0.095	0.0994	NS
PAAD	Pancreatic adenocarcinoma	176	0.104	0.17	NS
READ	Rectum adenocarcinoma	156	-0.061	0.451	NS
SKCM	Skin Cutaneous Melanoma	410	-0.054	0.28	NS
STAD	Stomach adenocarcinoma	392	0.084	0.0959	NS
TGCT	Testicular Germ Cell Tumors	81	0.065	0.565	NS
THCA	Thyroid carcinoma	499	-0.018	0.683	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.052	0.242	NS

> Grade

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Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	-0.051	0.401	NS
HNSC	Head and Neck squamous cell carcinoma	498	-0.017	0.699	NS
KIRC	Kidney renal clear cell carcinoma	525	-0.056	0.198	NS
LGG	Brain Lower Grade Glioma	514	0.128	0.00353	Higher
LIHC	Liver hepatocellular carcinoma	366	-0.036	0.487	NS
OV	Ovarian serous cystadenocarcinoma	296	0.047	0.417	NS
PAAD	Pancreatic adenocarcinoma	176	0.062	0.415	NS
STAD	Stomach adenocarcinoma	406	0.062	0.21	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.185	1.63e-05	Higher

Summary
Symbol	KDM5A
Name	lysine demethylase 5A
Aliases	RBBP2; JARID1A; retinoblastoma-binding protein 2; Jumonji, AT rich interactive domain 1A (RBBP2-like); jumon ......
Location	12p13.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	KDM5A
Name	lysine demethylase 5A
Aliases	RBBP2; JARID1A; retinoblastoma-binding protein 2; Jumonji, AT rich interactive domain 1A (RBBP2-like); jumon ......
Location	12p13.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for KDM5A.

Summary
Symbol	KDM5A
Name	lysine demethylase 5A
Aliases	RBBP2; JARID1A; retinoblastoma-binding protein 2; Jumonji, AT rich interactive domain 1A (RBBP2-like); jumon ......
Location	12p13.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

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PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
27548814	Neuroendocrine Neoplasm	partner	p21; p57	Negative correlation	The cell cycle inhibitors p21 and p57 decreased with RBP2 overexpression and increased upon its depletion, suggesting a regulatory role for RBP2 in cellular proliferation.
27114462	Acute megakaryoblastic Leukemia	partner	CBFA2T3/GLIS2; RBM15/MKL1; KMT2A	Mutually exclusive mutation	CBFA2T3/GLIS2 was identified in 16% of the cases; RBM15/MKL1, in 12%; NUP98/KDM5A and KMT2A rearrangements, in 9% each; and monosomy 7, in 6%. These aberrations were mutually exclusive
26841866	primary breast cancer	partner	EMSY; SIN3	Binding	Finally, by immunohistochemical staining of primary breast tissue microarrays we find that EMSY/KDM5A/SIN3B complex subunits are frequently overexpressed in primary breast cancer cases in a correlative manner.
25575817	Chronic Myeloid Leukemia	downstream	miR-21; PDCD4	Negative regulation; positive regulation	We identified miR-21 was directly downregulated by RBP2 and found that miR-21 downregulated PDCD4 expression in leukemia cells. By binding to miR-21 promoter and by demethylating of trimethylated H3K4 at the miR-21 locus, RBP2 downregulated miR-21 expression. This in turn activated PDCD4.
23922798	Hepatocellular Carcinoma	upstream	has-miR-212	Negative regulation	RBP2 is overexpressed in HCC and negatively regulated by hsa-miR-212.
23722541	Lung Carcinoma	partner	p27	Binding	Mechanistic investigations established that RBP2 bound directly to the p27, cyclin D1, and ITGB1 promoters and that exogenous expression of cyclin D1, cyclin E1, or ITGB1 was sufficient to rescue proliferation or migration/invasion, respectively.
23722541	Lung Carcinoma	downstream	cyclin D1; cyclin E1; CDKN1B; ITGB1	Positive regulation; positive regulation; negative regulation; positive regulation	RBP2 upregulated expression of cyclins D1 and E1 while suppressing the expression of cyclin-dependent kinase inhibitor p27 (CDKN1B), each contributing to RBP2-mediated cell proliferation. Expression microarray analyses revealed that RBP2 promoted expression of integrin-β1 (ITGB1), which is implicated in lung cancer metastasis.
23531517	Acute Myeloid Leukemia	partner	NUP98; HOXA/B	Fusion; correlation	Using split-signal fluorescence in situ hybridization, other NUP98-rearranged pediatric AML cases were identified, including several acute megakaryoblastic leukemia (AMKL) cases with a cytogenetically cryptic fusion of NUP98 to JARID1A (t(11;15)(p15;q35)). JARID1A NUP98/JARID1A cases were characterized by HOXA/B gene overexpression, which is a potential druggable pathway.
22937203	Breast Carcinoma	downstream	CDK inhibitors	Negative regulation	Furthermore, knockdown of KDM5A gene expression altered H3K4 methylation and induced upregulation of CDK inhibitors as well as genes mediating apoptotic cell death.
16419055	Leukemia	partner	NUP98	Fusion	JARID1A was identified as the fusion partner of NUP98 using 3' RACE, RT-PCR, and FISH. JARID1A, at 12p13, codes for retinoblastoma binding protein 2, a protein implicated in transcriptional regulation. This is the first report of JARID1A as a partner gene in leukemia.