CR2Cancer

Summary
Symbol	KDM5D
Name	lysine demethylase 5D
Aliases	KIAA0234; HYA; HY; SMCY; JARID1D; Jumonji, AT rich interactive domain 1D (RBP2-like); Smcy homolog, Y-linked ......
Location	Yq11.223
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

[ TOP ]

Domain

PF01388 ARID/BRIGHT DNA binding domain
PF02373 JmjC domain
PF02375 jmjN domain
PF00628 PHD-finger
PF08429 PLU-1-like protein
PF02928 C5HC2 zinc finger

Function

Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May play a role in spermatogenesis. Involved in transcriptional repression of diverse metastasis-associated genes; in this function seems to cooperate with ZMYND8. Suppresses prostate cancer cell invasion. Regulates androgen receptor (AR) transcriptional activity by demethylating H3K4me3 active transcription marks.

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification erase	Histone methylation	H3K4me3, H3K4me2	H3K4	17320160

> Gene Ontology [ TOP ]
Biological Process	GO:0002250 adaptive immune response GO:0002443 leukocyte mediated immunity GO:0002449 lymphocyte mediated immunity GO:0002456 T cell mediated immunity GO:0002457 T cell antigen processing and presentation GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0006482 protein demethylation GO:0008214 protein dealkylation GO:0016570 histone modification GO:0016577 histone demethylation GO:0019882 antigen processing and presentation GO:0034720 histone H3-K4 demethylation GO:0070076 histone lysine demethylation GO:0070988 demethylation
Molecular Function	GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors GO:0032451 demethylase activity GO:0032452 histone demethylase activity GO:0032453 histone demethylase activity (H3-K4 specific) GO:0051213 dioxygenase activity
Cellular Component	-

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-3214842: HDMs demethylate histones

Summary
Symbol	KDM5D
Name	lysine demethylase 5D
Aliases	KIAA0234; HYA; HY; SMCY; JARID1D; Jumonji, AT rich interactive domain 1D (RBP2-like); Smcy homolog, Y-linked ......
Location	Yq11.223
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM1211794	c.476G>A	p.R159H	Substitution - Missense	Large_intestine
COSM1162076	c.2434G>T	p.V812L	Substitution - Missense	Kidney
COSM1637003	c.2374C>T	p.R792C	Substitution - Missense	Bone
COSM1470015	c.3009G>A	p.L1003L	Substitution - coding silent	Large_intestine
COSM5981948	c.1716+2T>C	p.?	Unknown	Upper_aerodigestive_tract
COSM5413252	c.2377G>T	p.E793*	Substitution - Nonsense	Skin
COSM3144284	c.4052C>T	p.A1351V	Substitution - Missense	Upper_aerodigestive_tract
COSM4695028	c.2375G>A	p.R792H	Substitution - Missense	Large_intestine
COSM3800807	c.1920G>C	p.K640N	Substitution - Missense	Urinary_tract
COSM1737443	c.3326C>T	p.A1109V	Substitution - Missense	Central_nervous_system
COSM5695844	c.1020C>G	p.H340Q	Substitution - Missense	Soft_tissue
COSM1162076	c.2434G>T	p.V812L	Substitution - Missense	Kidney
COSM1470017	c.800delC	p.P267fs*5	Deletion - Frameshift	Large_intestine
COSM3364880	c.4169G>T	p.G1390V	Substitution - Missense	Kidney
COSM3914350	c.394C>T	p.R132C	Substitution - Missense	Skin
COSM1470012	c.4325G>A	p.R1442Q	Substitution - Missense	Large_intestine
COSM4157076	c.3939C>A	p.V1313V	Substitution - coding silent	Thyroid
COSM3584442	c.4432C>T	p.R1478*	Substitution - Nonsense	Skin
COSM1470013	c.4255C>T	p.R1419C	Substitution - Missense	Skin
COSM301583	c.2302C>T	p.R768*	Substitution - Nonsense	Large_intestine
COSM3584443	c.2846C>T	p.S949F	Substitution - Missense	Skin
COSM1470016	c.1380G>A	p.A460A	Substitution - coding silent	Large_intestine
COSM1683052	c.2905C>T	p.R969C	Substitution - Missense	Skin
COSM1211795	c.4177C>T	p.L1393F	Substitution - Missense	Large_intestine
COSM4541818	c.2983G>A	p.E995K	Substitution - Missense	Skin
COSM22858	c.469T>A	p.Y157N	Substitution - Missense	Skin
COSM3584444	c.2166C>T	p.S722S	Substitution - coding silent	Skin
COSM369622	c.1577G>T	p.G526V	Substitution - Missense	Lung
COSM1470014	c.3903G>A	p.Q1301Q	Substitution - coding silent	Large_intestine
COSM758039	c.4042G>T	p.E1348*	Substitution - Nonsense	Lung
COSM182704	c.3492A>G	p.P1164P	Substitution - coding silent	Large_intestine
COSM3144297	c.850A>G	p.T284A	Substitution - Missense	Upper_aerodigestive_tract
COSM5817881	c.2009T>A	p.L670Q	Substitution - Missense	Liver
COSM4401935	c.4067C>T	p.S1356F	Substitution - Missense	Skin
COSM3144295	c.1092G>A	p.A364A	Substitution - coding silent	Bone
COSM5564220	c.3454C>T	p.R1152C	Substitution - Missense	Prostate
COSM4887407	c.4069+1G>T	p.?	Unknown	Upper_aerodigestive_tract
COSM312109	c.3997A>G	p.K1333E	Substitution - Missense	Lung
COSM182706	c.1734G>A	p.Q578Q	Substitution - coding silent	Large_intestine
COSM4449952	c.4069+1G>A	p.?	Unknown	Skin
COSM4157075	c.3941A>C	p.Y1314S	Substitution - Missense	Thyroid
COSM3728128	c.290G>C	p.G97A	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1211796	c.4235C>A	p.P1412H	Substitution - Missense	Large_intestine
COSM4914649	c.870G>A	p.L290L	Substitution - coding silent	Liver
COSM4111729	c.3861T>A	p.D1287E	Substitution - Missense	Stomach
COSM1470013	c.4255C>T	p.R1419C	Substitution - Missense	Large_intestine
COSM1644110	c.3585G>C	p.W1195C	Substitution - Missense	Stomach
COSM6018865	c.4129G>C	p.E1377Q	Substitution - Missense	Skin
COSM488716	c.376G>A	p.E126K	Substitution - Missense	Kidney
COSM4802290	c.2502G>T	p.Q834H	Substitution - Missense	Liver
COSM4695029	c.638C>T	p.A213V	Substitution - Missense	Large_intestine
COSM758040	c.4299G>C	p.R1433R	Substitution - coding silent	Lung
COSM4993593	c.588C>T	p.P196P	Substitution - coding silent	Skin
COSM170529	c.3229C>A	p.L1077I	Substitution - Missense	Large_intestine
COSM1293087	c.1513A>G	p.I505V	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4005203	c.637G>A	p.A213T	Substitution - Missense	Urinary_tract
COSM3584445	c.1762C>T	p.P588S	Substitution - Missense	Skin
COSM404209	c.379G>T	p.A127S	Substitution - Missense	Lung
COSM4802290	c.2502G>T	p.Q834H	Substitution - Missense	Liver
COSM3408051	c.919A>T	p.S307C	Substitution - Missense	Central_nervous_system
COSM6005444	c.352-3C>T	p.?	Unknown	Prostate
COSM1726212	c.1891G>C	p.V631L	Substitution - Missense	Liver
COSM3391915	c.2174A>G	p.N725S	Substitution - Missense	Pancreas
COSM3944536	c.899T>C	p.M300T	Substitution - Missense	Lung
COSM182711	c.341G>A	p.S114N	Substitution - Missense	Large_intestine
COSM4909469	c.556A>G	p.K186E	Substitution - Missense	Liver
COSM4386508	c.407G>A	p.R136Q	Substitution - Missense	Large_intestine
COSM1715921	c.2165C>T	p.S722F	Substitution - Missense	Skin
COSM758038	c.934-1G>T	p.?	Unknown	Lung
COSM758037	c.550G>T	p.E184*	Substitution - Nonsense	Lung
COSM3702267	c.3432G>C	p.E1144D	Substitution - Missense	Liver
COSM4636545	c.1942T>C	p.L648L	Substitution - coding silent	Large_intestine
COSM3914349	c.1870C>G	p.R624G	Substitution - Missense	Skin

> Text Mining based Variations [ TOP ]
There is no record for KDM5D.

Summary
Symbol	KDM5D
Name	lysine demethylase 5D
Aliases	KIAA0234; HYA; HY; SMCY; JARID1D; Jumonji, AT rich interactive domain 1D (RBP2-like); Smcy homolog, Y-linked ......
Location	Yq11.223
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM) [ TOP ]
There is no PTM data

Summary
Symbol	KDM5D
Name	lysine demethylase 5D
Aliases	KIAA0234; HYA; HY; SMCY; JARID1D; Jumonji, AT rich interactive domain 1D (RBP2-like); Smcy homolog, Y-linked ......
Location	Yq11.223
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

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Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	5.079	4.148	1.442	0.289	NS
COAD	Colon adenocarcinoma	41	459	-3.385	1.45	0.027	0.976	NS
ESCA	Esophageal carcinoma	11	185	5.665	3.382	1.718	0.277	NS
GBM	Glioblastoma multiforme	5	166	5.592	4.722	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	4.852	2.953	-0.525	0.512	NS
KIRC	Kidney renal clear cell carcinoma	72	534	5.018	4.022	-0.935	0.163	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	5.184	2.052	-1.128	0.2	NS
LAML	Acute Myeloid Leukemia	0	173	NA	6.525	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	4.796	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	3.717	3.315	0.861	0.278	NS
LUAD	Lung adenocarcinoma	59	517	-4.177	-3.728	0.104	0.905	NS
LUSC	Lung squamous cell carcinoma	51	501	4.975	3.436	-0.51	0.485	NS
PAAD	Pancreatic adenocarcinoma	4	179	0.602	3.734	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	6.268	-3.23	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	5.845	5.833	-0.006	0.951	NS
READ	Rectum adenocarcinoma	10	167	-6.035	1.668	2.486	0.17	NS
SARC	Sarcoma	2	263	1.532	-3.047	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	6.491	2.759	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	5.205	3.031	-1.289	0.2	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	5.852	NA	NA	NA
THCA	Thyroid carcinoma	59	509	-6.678	-6.306	0.23	0.787	NS
THYM	Thymoma	2	120	-6.928	4.78	NA	NA	NA

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	0.1
Adrenal gland	0
Appendix	15
Bone marrow	9.4
Breast	0
Cerebral cortex	9.1
Cervix, uterine	0
Colon	7.4
Duodenum	16.6
Endometrium	0
Epididymis	17.4
Esophagus	12.1
Fallopian tube	0
Gallbladder	17.1
Heart muscle	3.9
Kidney	2.9
Liver	3.8
Lung	8.4
Lymph node	10.8
Ovary	0
Pancreas	1.9
Parathyroid gland	0
Placenta	12.6
Prostate	25.5
Rectum	22.7
Salivary gland	2.1
Seminal vesicle	23.9
Skeletal muscle	2.9
Skin	11.4
Small intestine	37.3
Smooth muscle	0
Spleen	17.5
Stomach	11.1
Testis	21.4
Thyroid gland	4.3
Tonsil	17.3
Urinary bladder	20.3

> Text Mining based Expression

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PMID	Expression	Cancer	Evidence
26747897	Underexpression	Metastatic Prostate Carcinoma	Our additional results demonstrated that JARID1D levels were highly downregulated in metastatic prostate tumors compared with normal prostate tissues and primary prostate tumors.

Summary
Symbol	KDM5D
Name	lysine demethylase 5D
Aliases	KIAA0234; HYA; HY; SMCY; JARID1D; Jumonji, AT rich interactive domain 1D (RBP2-like); Smcy homolog, Y-linked ......
Location	Yq11.223
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

Summary
Symbol	KDM5D
Name	lysine demethylase 5D
Aliases	KIAA0234; HYA; HY; SMCY; JARID1D; Jumonji, AT rich interactive domain 1D (RBP2-like); Smcy homolog, Y-linked ......
Location	Yq11.223
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.757	0	17	408	NA	0.0495	NS/NA
ESCA	Esophageal carcinoma	-0.828	0	9	185	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.699	0	20	522	NA	0.0732	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.656	0	24	319	NA	1.39e-07	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.668	0	23	275	NA	5.77e-21	NS/NA
LGG	Brain Lower Grade Glioma	-0.291	1.04e-10	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.624	4.17e-42	41	373	NA	0.0312	NS/NA
LUSC	Lung squamous cell carcinoma	-0.73	0	8	370	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.645	1.29e-21	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.665	5.34e-25	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.134	0.00198	35	498	0.027	3.03e-05	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.657	0	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.722	0	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.535	0	0	156	NA	NA	NS/NA
THYM	Thymoma	-0.699	0	2	120	NA	NA	NS/NA

Summary
Symbol	KDM5D
Name	lysine demethylase 5D
Aliases	KIAA0234; HYA; HY; SMCY; JARID1D; Jumonji, AT rich interactive domain 1D (RBP2-like); Smcy homolog, Y-linked ......
Location	Yq11.223
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA) [ TOP ]
There is no antibody staining data.

Summary
Symbol	KDM5D
Name	lysine demethylase 5D
Aliases	KIAA0234; HYA; HY; SMCY; JARID1D; Jumonji, AT rich interactive domain 1D (RBP2-like); Smcy homolog, Y-linked ......
Location	Yq11.223
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

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Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.00419	Significant	24476821
COAD	Colon adenocarcinoma	149	0.102	NS	22810696
GBM	Glioblastoma multiforme	157	0.32	NS	26824661
HNSC	Head and Neck squamous cell carcinoma	279	0.0187	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.792	NS	26536169
LGG	Brain Lower Grade Glioma	513	0.453	NS	26824661
LUAD	Lung adenocarcinoma	230	2.28e-05	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	0.717	NS	22960745
PRAD	Prostate adenocarcinoma	333	8.95e-23	Significant	26544944
READ	Rectum adenocarcinoma	67	0.38	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.865	NS	26091043
STAD	Stomach adenocarcinoma	277	0.000109	Significant	25079317
THCA	Thyroid carcinoma	391	0.61	NS	25417114

> Overall survival

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Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	0.766	0.227	NS
COAD	Colon adenocarcinoma	439	1.266	0.431	NS
ESCA	Esophageal carcinoma	184	1.628	0.156	NS
GBM	Glioblastoma multiforme	158	0.87	0.586	NS
HNSC	Head and Neck squamous cell carcinoma	518	0.537	0.0021	Longer
KIRC	Kidney renal clear cell carcinoma	531	1.102	0.648	NS
KIRP	Kidney renal papillary cell carcinoma	287	0.902	0.794	NS
LAML	Acute Myeloid Leukemia	149	0.632	0.117	NS
LGG	Brain Lower Grade Glioma	511	0.923	0.768	NS
LIHC	Liver hepatocellular carcinoma	365	0.68	0.133	NS
LUAD	Lung adenocarcinoma	502	0.948	0.8	NS
LUSC	Lung squamous cell carcinoma	494	1.099	0.642	NS
PAAD	Pancreatic adenocarcinoma	177	0.845	0.624	NS
PCPG	Pheochromocytoma and Paraganglioma	179	2.041	0.552	NS
PRAD	Prostate adenocarcinoma	497	1.488	0.603	NS
READ	Rectum adenocarcinoma	159	0.74	0.591	NS
SARC	Sarcoma	259	0.821	0.486	NS
SKCM	Skin Cutaneous Melanoma	459	1.225	0.307	NS
STAD	Stomach adenocarcinoma	388	1.129	0.592	NS
TGCT	Testicular Germ Cell Tumors	134	594299979.502	0.317	NS
THCA	Thyroid carcinoma	500	2.731	0.215	NS
THYM	Thymoma	119	0.268	0.223	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	-0.047	0.346	NS
COAD	Colon adenocarcinoma	445	-0.04	0.397	NS
ESCA	Esophageal carcinoma	162	0.126	0.109	NS
HNSC	Head and Neck squamous cell carcinoma	448	0.007	0.885	NS
KIRC	Kidney renal clear cell carcinoma	531	0.096	0.0272	Higher
KIRP	Kidney renal papillary cell carcinoma	260	0.001	0.981	NS
LIHC	Liver hepatocellular carcinoma	347	-0.124	0.021	Lower
LUAD	Lung adenocarcinoma	507	0.026	0.554	NS
LUSC	Lung squamous cell carcinoma	497	-0.014	0.758	NS
PAAD	Pancreatic adenocarcinoma	176	-0.015	0.842	NS
READ	Rectum adenocarcinoma	156	-0.017	0.833	NS
SKCM	Skin Cutaneous Melanoma	410	-0.018	0.712	NS
STAD	Stomach adenocarcinoma	392	0.029	0.567	NS
TGCT	Testicular Germ Cell Tumors	81	-0.303	0.00594	Lower
THCA	Thyroid carcinoma	499	0.132	0.00323	Higher

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
HNSC	Head and Neck squamous cell carcinoma	498	0.146	0.00104	Higher
KIRC	Kidney renal clear cell carcinoma	525	0.119	0.00653	Higher
LGG	Brain Lower Grade Glioma	514	-0.02	0.644	NS
LIHC	Liver hepatocellular carcinoma	366	-0.091	0.0833	NS
PAAD	Pancreatic adenocarcinoma	176	0.111	0.142	NS
STAD	Stomach adenocarcinoma	406	0.003	0.956	NS

Summary
Symbol	KDM5D
Name	lysine demethylase 5D
Aliases	KIAA0234; HYA; HY; SMCY; JARID1D; Jumonji, AT rich interactive domain 1D (RBP2-like); Smcy homolog, Y-linked ......
Location	Yq11.223
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	KDM5D
Name	lysine demethylase 5D
Aliases	KIAA0234; HYA; HY; SMCY; JARID1D; Jumonji, AT rich interactive domain 1D (RBP2-like); Smcy homolog, Y-linked ......
Location	Yq11.223
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database

[ TOP ]

DrugBank ID	Name	Type	All Targets
DB00126	Vitamin C	Small Molecule Drug

Summary
Symbol	KDM5D
Name	lysine demethylase 5D
Aliases	KIAA0234; HYA; HY; SMCY; JARID1D; Jumonji, AT rich interactive domain 1D (RBP2-like); Smcy homolog, Y-linked ......
Location	Yq11.223
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
26747897	Metastatic Prostate Carcinoma	partner	H3K4	demethylation	We found that JARID1D specifically repressed the invasion-associated genes MMP1, MMP2, MMP3, MMP7, and Slug by demethylating trimethyl H3K4, a gene-activating mark, at their promoters.
26747897	Metastatic Prostate Carcinoma	downstream	MMP1; MMP2; MMP3; MMP7; Slug	Negative regulation	We found that JARID1D specifically repressed the invasion-associated genes MMP1, MMP2, MMP3, MMP7, and Slug by demethylating trimethyl H3K4, a gene-activating mark, at their promoters.