CR2Cancer

Summary
Symbol	KDM6B
Name	lysine demethylase 6B
Aliases	KIAA0346; JMJD3; jumonji domain containing 3; jumonji domain containing 3, histone lysine demethylase; jmjC ......
Location	17p13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

[ TOP ]

Domain

PF02373 JmjC domain

Function

Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code (PubMed:17825402, PubMed:17851529, PubMed:17713478, PubMed:18003914). Demethylates trimethylated and dimethylated H3 'Lys-27' (PubMed:17825402, PubMed:17851529, PubMed:17713478, PubMed:18003914). Plays a central role in regulation of posterior development, by regulating HOX gene expression (PubMed:17851529). Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation (PubMed:17825402).

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification erase	Histone methylation	H3K27me2. H3K27me4	H3K28	17851529

> Gene Ontology [ TOP ]
Biological Process	GO:0000302 response to reactive oxygen species GO:0001704 formation of primary germ layer GO:0001707 mesoderm formation GO:0002437 inflammatory response to antigenic stimulus GO:0003158 endothelium development GO:0006482 protein demethylation GO:0006979 response to oxidative stress GO:0007369 gastrulation GO:0007498 mesoderm development GO:0007507 heart development GO:0008214 protein dealkylation GO:0009636 response to toxic substance GO:0010035 response to inorganic substance GO:0014706 striated muscle tissue development GO:0014823 response to activity GO:0016570 histone modification GO:0016577 histone demethylation GO:0021537 telencephalon development GO:0021543 pallium development GO:0021761 limbic system development GO:0021766 hippocampus development GO:0030900 forebrain development GO:0034599 cellular response to oxidative stress GO:0034614 cellular response to reactive oxygen species GO:0035051 cardiocyte differentiation GO:0042542 response to hydrogen peroxide GO:0042692 muscle cell differentiation GO:0045165 cell fate commitment GO:0045446 endothelial cell differentiation GO:0048332 mesoderm morphogenesis GO:0048333 mesodermal cell differentiation GO:0048738 cardiac muscle tissue development GO:0051146 striated muscle cell differentiation GO:0055007 cardiac muscle cell differentiation GO:0060537 muscle tissue development GO:0060992 response to fungicide GO:0070076 histone lysine demethylation GO:0070301 cellular response to hydrogen peroxide GO:0070988 demethylation GO:0071557 histone H3-K27 demethylation
Molecular Function	GO:0003682 chromatin binding GO:0008013 beta-catenin binding GO:0032451 demethylase activity GO:0032452 histone demethylase activity GO:0051213 dioxygenase activity GO:0071558 histone demethylase activity (H3-K27 specific)
Cellular Component	-

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-2559583: Cellular Senescence R-HSA-2262752: Cellular responses to stress R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-3214842: HDMs demethylate histones R-HSA-2559580: Oxidative Stress Induced Senescence

Summary
Symbol	KDM6B
Name	lysine demethylase 6B
Aliases	KIAA0346; JMJD3; jumonji domain containing 3; jumonji domain containing 3, histone lysine demethylase; jmjC ......
Location	17p13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM1169351	c.1297T>C	p.S433P	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4979945	c.2412C>T	p.L804L	Substitution - coding silent	Oesophagus
COSM5771773	c.3827C>G	p.T1276S	Substitution - Missense	Breast
COSM2802553	c.397G>A	p.A133T	Substitution - Missense	Large_intestine
COSM359056	c.2010C>G	p.L670L	Substitution - coding silent	Lung
COSM4603241	c.761_762insACCACC	p.P264_L265insPP	Insertion - In frame	Upper_aerodigestive_tract
COSM5496287	c.2280C>G	p.T760T	Substitution - coding silent	Biliary_tract
COSM4603241	c.761_762insACCACC	p.P264_L265insPP	Insertion - In frame	Upper_aerodigestive_tract
COSM1610922	c.723C>T	p.P241P	Substitution - coding silent	Liver
COSM3725275	c.2170C>A	p.P724T	Substitution - Missense	Lung
COSM3378378	c.2547G>A	p.P849P	Substitution - coding silent	Pancreas
COSM5496287	c.2280C>G	p.T760T	Substitution - coding silent	Biliary_tract
COSM5422190	c.1836C>G	p.S612S	Substitution - coding silent	Prostate
COSM1679534	c.2446T>G	p.Y816D	Substitution - Missense	Large_intestine
COSM4070284	c.1193C>G	p.T398S	Substitution - Missense	Stomach
COSM4440488	c.2520delC	p.P842fs*52	Deletion - Frameshift	Thyroid
COSM4614819	c.2703_2705delCCT	p.L902delL	Deletion - In frame	Large_intestine
COSM3746461	c.752T>C	p.L251S	Substitution - Missense	Liver
COSM985377	c.752_753insACCACC	p.P264_L265insPP	Insertion - In frame	Liver
COSM1387272	c.4669G>A	p.A1557T	Substitution - Missense	Large_intestine
COSM3712467	c.3276G>T	p.L1092L	Substitution - coding silent	Upper_aerodigestive_tract
COSM5562300	c.1126C>G	p.P376A	Substitution - Missense	Prostate
COSM5387543	c.1030G>A	p.A344T	Substitution - Missense	Skin
COSM4634274	c.797C>A	p.P266H	Substitution - Missense	Large_intestine
COSM4987393	c.2258C>T	p.T753I	Substitution - Missense	Soft_tissue
COSM2802596	c.1875G>A	p.P625P	Substitution - coding silent	Stomach
COSM4895343	c.2640G>A	p.R880R	Substitution - coding silent	Skin
COSM985381	c.1587G>A	p.P529P	Substitution - coding silent	Endometrium
COSM1161219	c.117C>T	p.S39S	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM5020393	c.607C>G	p.P203A	Substitution - Missense	Soft_tissue
COSM4130750	c.2145C>T	p.H715H	Substitution - coding silent	Soft_tissue
COSM437697	c.753_761delACCACCACC	p.P262_P264delPPP	Deletion - In frame	Large_intestine
COSM5614524	c.3348G>T	p.E1116D	Substitution - Missense	Lung
COSM4130749	c.807T>C	p.A269A	Substitution - coding silent	Thyroid
COSM985380	c.1383G>A	p.L461L	Substitution - coding silent	Endometrium
COSM5599760	c.3860C>T	p.S1287F	Substitution - Missense	Skin
COSM5018159	c.2374_2376delCCA	p.P798delP	Deletion - In frame	Soft_tissue
COSM3717729	c.2068A>T	p.I690F	Substitution - Missense	Liver
COSM5812078	c.2146G>T	p.E716*	Substitution - Nonsense	Liver
COSM2802648	c.4582A>G	p.S1528G	Substitution - Missense	Large_intestine
COSM4272855	c.757C>T	p.P253S	Substitution - Missense	Biliary_tract
COSM5649971	c.753_755delACC	p.P264delP	Deletion - In frame	Oesophagus
COSM4987391	c.2254A>G	p.T752A	Substitution - Missense	Soft_tissue
COSM4695059	c.4031T>C	p.L1344P	Substitution - Missense	Large_intestine
COSM5913897	c.862G>A	p.D288N	Substitution - Missense	Skin
COSM3523217	c.2769C>T	p.T923T	Substitution - coding silent	Skin
COSM4130750	c.2145C>T	p.H715H	Substitution - coding silent	Thyroid
COSM5559608	c.1375C>A	p.L459I	Substitution - Missense	Prostate
COSM3691899	c.4697G>A	p.R1566H	Substitution - Missense	Large_intestine
COSM4431337	c.3447C>T	p.A1149A	Substitution - coding silent	Oesophagus
COSM5020639	c.923C>T	p.S308L	Substitution - Missense	Soft_tissue
COSM1679534	c.2446T>G	p.Y816D	Substitution - Missense	Large_intestine
COSM4475228	c.1972C>A	p.P658T	Substitution - Missense	Skin
COSM4960640	c.1993G>A	p.A665T	Substitution - Missense	Liver
COSM4635972	c.4599C>T	p.F1533F	Substitution - coding silent	Large_intestine
COSM473480	c.2635G>T	p.A879S	Substitution - Missense	Upper_aerodigestive_tract
COSM3937637	c.2222C>G	p.A741G	Substitution - Missense	Oesophagus
COSM1750410	c.4383C>T	p.L1461L	Substitution - coding silent	Urinary_tract
COSM4070278	c.40C>T	p.R14W	Substitution - Missense	Stomach
COSM5629548	c.4684G>T	p.A1562S	Substitution - Missense	Oesophagus
COSM4986867	c.2924G>A	p.R975Q	Substitution - Missense	Soft_tissue
COSM5499280	c.3988A>G	p.T1330A	Substitution - Missense	Biliary_tract
COSM5493519	c.3043C>T	p.R1015C	Substitution - Missense	Biliary_tract
COSM4603241	c.761_762insACCACC	p.P264_L265insPP	Insertion - In frame	Upper_aerodigestive_tract
COSM4695052	c.1063delC	p.G357fs*130	Deletion - Frameshift	Large_intestine
COSM4496218	c.4707C>T	p.D1569D	Substitution - coding silent	Prostate
COSM5516756	c.2889C>T	p.G963G	Substitution - coding silent	Biliary_tract
COSM4641110	c.712A>G	p.T238A	Substitution - Missense	Upper_aerodigestive_tract
COSM5569156	c.3740C>T	p.T1247I	Substitution - Missense	Prostate
COSM5696479	c.3158C>T	p.P1053L	Substitution - Missense	Soft_tissue
COSM211589	c.4432T>G	p.C1478G	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4987393	c.2258C>T	p.T753I	Substitution - Missense	Soft_tissue
COSM5893923	c.2579C>T	p.S860F	Substitution - Missense	Skin
COSM1679533	c.1033G>A	p.E345K	Substitution - Missense	Large_intestine
COSM5433399	c.84G>C	p.W28C	Substitution - Missense	Oesophagus
COSM4956255	c.3818C>T	p.S1273F	Substitution - Missense	Liver
COSM5959281	c.2716C>G	p.P906A	Substitution - Missense	Upper_aerodigestive_tract
COSM4956255	c.3818C>T	p.S1273F	Substitution - Missense	Liver
COSM4603241	c.761_762insACCACC	p.P264_L265insPP	Insertion - In frame	Upper_aerodigestive_tract
COSM1387257	c.74C>T	p.A25V	Substitution - Missense	Large_intestine
COSM4495020	c.4446C>T	p.A1482A	Substitution - coding silent	Skin
COSM3378377	c.496C>T	p.R166*	Substitution - Nonsense	Pancreas
COSM473480	c.2635G>T	p.A879S	Substitution - Missense	Biliary_tract
COSM1679532	c.643T>G	p.S215A	Substitution - Missense	Large_intestine
COSM4416780	c.1782C>A	p.P594P	Substitution - coding silent	Soft_tissue
COSM4878643	c.3643A>T	p.I1215F	Substitution - Missense	Prostate
COSM1211799	c.2059G>A	p.E687K	Substitution - Missense	Large_intestine
COSM5020639	c.923C>T	p.S308L	Substitution - Missense	Soft_tissue
COSM473480	c.2635G>T	p.A879S	Substitution - Missense	Oesophagus
COSM229296	c.4819C>T	p.R1607W	Substitution - Missense	Skin
COSM1189394	c.1336C>T	p.R446W	Substitution - Missense	Lung
COSM5585571	c.1838C>T	p.S613F	Substitution - Missense	Skin
COSM3770482	c.2684C>A	p.P895H	Substitution - Missense	Soft_tissue
COSM5456650	c.1106G>A	p.R369Q	Substitution - Missense	Large_intestine
COSM349454	c.803T>A	p.L268Q	Substitution - Missense	Lung
COSM5853682	c.941C>T	p.P314L	Substitution - Missense	Skin
COSM707752	c.2194C>G	p.L732V	Substitution - Missense	Lung
COSM1387273	c.4858G>T	p.E1620*	Substitution - Nonsense	Large_intestine
COSM5017373	c.767_768insAAT	p.P256_P257insI	Insertion - In frame	Soft_tissue
COSM4989126	c.2281A>G	p.T761A	Substitution - Missense	Soft_tissue
COSM5972472	c.1914C>T	p.P638P	Substitution - coding silent	Upper_aerodigestive_tract
COSM5433864	c.1427T>C	p.L476P	Substitution - Missense	Oesophagus
COSM5020229	c.1330A>G	p.S444G	Substitution - Missense	Soft_tissue
COSM4070291	c.3787C>T	p.R1263W	Substitution - Missense	Skin
COSM88033	c.3466C>T	p.R1156*	Substitution - Nonsense	Skin
COSM5464213	c.32G>A	p.R11H	Substitution - Missense	Large_intestine
COSM4695053	c.1432_1433insA	p.R478fs*32	Insertion - Frameshift	Large_intestine
COSM143705	c.2426_2427CC>TT	p.S809F	Substitution - Missense	Skin
COSM5055837	c.3423C>T	p.D1141D	Substitution - coding silent	Stomach
COSM4565265	c.1921_1922GG>AA	p.G641K	Substitution - Missense	Skin
COSM232567	c.3409C>A	p.H1137N	Substitution - Missense	Skin
COSM3755968	c.1444C>T	p.P482S	Substitution - Missense	Large_intestine
COSM4695054	c.1624_1625insC	p.P544fs*11	Insertion - Frameshift	Large_intestine
COSM707758	c.650C>T	p.P217L	Substitution - Missense	Lung
COSM5937724	c.2179G>A	p.E727K	Substitution - Missense	Skin
COSM229580	c.3530C>T	p.P1177L	Substitution - Missense	Skin
COSM5599760	c.3860C>T	p.S1287F	Substitution - Missense	Skin
COSM5768277	c.4584C>T	p.S1528S	Substitution - coding silent	Breast
COSM4766940	c.2920C>T	p.R974W	Substitution - Missense	Stomach
COSM3932767	c.989T>G	p.V330G	Substitution - Missense	Urinary_tract
COSM4885848	c.113G>T	p.R38L	Substitution - Missense	Upper_aerodigestive_tract
COSM4695055	c.3092G>A	p.R1031H	Substitution - Missense	Large_intestine
COSM5930342	c.2086G>A	p.A696T	Substitution - Missense	Skin
COSM985382	c.2253_2258delCACCAC	p.T761_T762delTT	Deletion - In frame	Upper_aerodigestive_tract
COSM4989126	c.2281A>G	p.T761A	Substitution - Missense	Biliary_tract
COSM4695056	c.3190delC	p.P1065fs*26	Deletion - Frameshift	Large_intestine
COSM1750410	c.4383C>T	p.L1461L	Substitution - coding silent	Urinary_tract
COSM4933258	c.2070C>T	p.I690I	Substitution - coding silent	Liver
COSM5364094	c.3487G>A	p.A1163T	Substitution - Missense	Large_intestine
COSM707757	c.686G>A	p.R229Q	Substitution - Missense	Lung
COSM4987391	c.2254A>G	p.T752A	Substitution - Missense	Soft_tissue
COSM4695051	c.752_753insACC	p.P264_L265insP	Insertion - In frame	Large_intestine
COSM3691898	c.1318C>T	p.P440S	Substitution - Missense	Large_intestine
COSM4130747	c.177C>T	p.P59P	Substitution - coding silent	Thyroid
COSM5826000	c.2252_2253insCAC	p.T762_A763insT	Insertion - In frame	Large_intestine
COSM4615600	c.3021_3026delCAAGGT	p.K1008_V1009delKV	Deletion - In frame	Large_intestine
COSM985387	c.4384G>A	p.V1462M	Substitution - Missense	Endometrium
COSM5559608	c.1375C>A	p.L459I	Substitution - Missense	Prostate
COSM985382	c.2253_2258delCACCAC	p.T761_T762delTT	Deletion - In frame	Upper_aerodigestive_tract
COSM985377	c.752_753insACCACC	p.P264_L265insPP	Insertion - In frame	Endometrium
COSM5921170	c.2192C>T	p.S731F	Substitution - Missense	Skin
COSM4603241	c.761_762insACCACC	p.P264_L265insPP	Insertion - In frame	Upper_aerodigestive_tract
COSM4603241	c.761_762insACCACC	p.P264_L265insPP	Insertion - In frame	Upper_aerodigestive_tract
COSM5576738	c.1342C>T	p.P448S	Substitution - Missense	Skin
COSM1303430	c.1410A>C	p.P470P	Substitution - coding silent	Urinary_tract
COSM4966265	c.549G>A	p.E183E	Substitution - coding silent	Prostate
COSM84371	c.3195G>A	p.P1065P	Substitution - coding silent	Pancreas
COSM1169351	c.1297T>C	p.S433P	Substitution - Missense	Soft_tissue
COSM473482	c.4667G>A	p.R1556Q	Substitution - Missense	Kidney
COSM1318422	c.881G>A	p.R294H	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3755969	c.2172G>A	p.P724P	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM1721253	c.3546delC	p.P1184fs*31	Deletion - Frameshift	Skin
COSM4987165	c.2032C>A	p.L678M	Substitution - Missense	Soft_tissue
COSM1189393	c.275C>G	p.S92C	Substitution - Missense	Lung
COSM5599760	c.3860C>T	p.S1287F	Substitution - Missense	Skin
COSM4130748	c.181C>T	p.P61S	Substitution - Missense	Thyroid
COSM4614818	c.1974_1975insG	p.V660fs*13	Insertion - Frameshift	Large_intestine
COSM3989394	c.4230G>C	p.W1410C	Substitution - Missense	Kidney
COSM3989395	c.4269T>G	p.A1423A	Substitution - coding silent	Kidney
COSM3523218	c.3861C>T	p.S1287S	Substitution - coding silent	Skin
COSM1679533	c.1033G>A	p.E345K	Substitution - Missense	Large_intestine
COSM4130750	c.2145C>T	p.H715H	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM985382	c.2253_2258delCACCAC	p.T761_T762delTT	Deletion - In frame	Endometrium
COSM5731366	c.4500C>T	p.Y1500Y	Substitution - coding silent	Central_nervous_system
COSM4695050	c.549+2T>C	p.?	Unknown	Large_intestine
COSM4272870	c.2599T>G	p.S867A	Substitution - Missense	Large_intestine
COSM118307	c.3828C>T	p.T1276T	Substitution - coding silent	Ovary
COSM1480123	c.2253_2255delCAC	p.T762delT	Deletion - In frame	Skin
COSM4695058	c.3666G>A	p.L1222L	Substitution - coding silent	Large_intestine
COSM5037548	c.2705T>C	p.L902P	Substitution - Missense	Skin
COSM5019922	c.456+6A>G	p.?	Unknown	Soft_tissue
COSM3820842	c.3309G>A	p.L1103L	Substitution - coding silent	Breast
COSM3362395	c.3542T>C	p.L1181P	Substitution - Missense	Kidney
COSM1211800	c.1756C>T	p.R586W	Substitution - Missense	Large_intestine
COSM1679533	c.1033G>A	p.E345K	Substitution - Missense	Large_intestine
COSM3989393	c.2150C>T	p.A717V	Substitution - Missense	Kidney
COSM2152632	c.3149C>T	p.P1050L	Substitution - Missense	Central_nervous_system
COSM5456651	c.3667C>T	p.R1223W	Substitution - Missense	Large_intestine
COSM1387271	c.4301C>T	p.T1434M	Substitution - Missense	Large_intestine
COSM5788074	c.4197C>G	p.V1399V	Substitution - coding silent	Breast
COSM3378378	c.2547G>A	p.P849P	Substitution - coding silent	Pancreas
COSM4537951	c.2483G>A	p.R828Q	Substitution - Missense	Skin
COSM211589	c.4432T>G	p.C1478G	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4960640	c.1993G>A	p.A665T	Substitution - Missense	Liver
COSM473480	c.2635G>T	p.A879S	Substitution - Missense	Upper_aerodigestive_tract
COSM5021081	c.3795C>A	p.I1265I	Substitution - coding silent	Soft_tissue
COSM2802635	c.3626G>A	p.R1209Q	Substitution - Missense	Large_intestine
COSM4170847	c.416G>A	p.S139N	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5643716	c.3316C>T	p.R1106W	Substitution - Missense	Oesophagus
COSM437697	c.753_761delACCACCACC	p.P262_P264delPPP	Deletion - In frame	Upper_aerodigestive_tract
COSM1679532	c.643T>G	p.S215A	Substitution - Missense	Large_intestine
COSM4989126	c.2281A>G	p.T761A	Substitution - Missense	Soft_tissue
COSM5981138	c.835C>T	p.P279S	Substitution - Missense	Upper_aerodigestive_tract
COSM5923214	c.3736C>T	p.R1246C	Substitution - Missense	Skin
COSM4989126	c.2281A>G	p.T761A	Substitution - Missense	Biliary_tract
COSM4630359	c.2951G>A	p.R984Q	Substitution - Missense	Large_intestine
COSM4070282	c.917G>A	p.R306Q	Substitution - Missense	Stomach
COSM4426912	c.3626G>T	p.R1209L	Substitution - Missense	Oesophagus
COSM2802616	c.2601G>A	p.S867S	Substitution - coding silent	Large_intestine
COSM4603241	c.761_762insACCACC	p.P264_L265insPP	Insertion - In frame	Upper_aerodigestive_tract
COSM211589	c.4432T>G	p.C1478G	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1387266	c.2154C>T	p.G718G	Substitution - coding silent	Stomach
COSM5454621	c.4737+9G>A	p.?	Unknown	Large_intestine
COSM4646566	c.1688G>A	p.S563N	Substitution - Missense	Large_intestine
COSM4603241	c.761_762insACCACC	p.P264_L265insPP	Insertion - In frame	Upper_aerodigestive_tract
COSM4603241	c.761_762insACCACC	p.P264_L265insPP	Insertion - In frame	Upper_aerodigestive_tract
COSM4469291	c.1592C>G	p.S531C	Substitution - Missense	Skin
COSM3717730	c.2069T>G	p.I690S	Substitution - Missense	Liver
COSM1161219	c.117C>T	p.S39S	Substitution - coding silent	Stomach
COSM4603241	c.761_762insACCACC	p.P264_L265insPP	Insertion - In frame	Upper_aerodigestive_tract
COSM5893923	c.2579C>T	p.S860F	Substitution - Missense	Skin
COSM4070290	c.3718G>A	p.E1240K	Substitution - Missense	Stomach
COSM3717730	c.2069T>G	p.I690S	Substitution - Missense	Liver
COSM4603241	c.761_762insACCACC	p.P264_L265insPP	Insertion - In frame	Upper_aerodigestive_tract
COSM3755969	c.2172G>A	p.P724P	Substitution - coding silent	Thyroid
COSM4695049	c.112C>T	p.R38C	Substitution - Missense	Large_intestine
COSM3820841	c.899C>T	p.P300L	Substitution - Missense	Breast
COSM4130750	c.2145C>T	p.H715H	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM3783116	c.3104G>T	p.R1035L	Substitution - Missense	Prostate
COSM2802619	c.2651C>T	p.A884V	Substitution - Missense	Thyroid
COSM297759	c.1955delC	p.Q654fs*46	Deletion - Frameshift	Large_intestine
COSM4695057	c.3424G>A	p.V1142I	Substitution - Missense	Large_intestine
COSM3691897	c.437G>A	p.R146H	Substitution - Missense	Large_intestine
COSM5606238	c.999_1000insC	p.G336fs*24	Insertion - Frameshift	Skin
COSM3523213	c.2417C>T	p.S806F	Substitution - Missense	Skin
COSM985378	c.978C>T	p.G326G	Substitution - coding silent	Endometrium
COSM985376	c.96G>A	p.P32P	Substitution - coding silent	Endometrium
COSM4695060	c.4521C>T	p.N1507N	Substitution - coding silent	Large_intestine
COSM5343043	c.4067T>C	p.V1356A	Substitution - Missense	Large_intestine
COSM4070285	c.1265C>T	p.A422V	Substitution - Missense	Stomach
COSM3932766	c.704C>G	p.S235C	Substitution - Missense	Urinary_tract
COSM985388	c.4695C>A	p.G1565G	Substitution - coding silent	Endometrium
COSM4746654	c.2167delC	p.P724fs*2	Deletion - Frameshift	Stomach
COSM5038636	c.3884_3886delAGA	p.K1296delK	Deletion - In frame	Liver
COSM4070293	c.4716C>A	p.A1572A	Substitution - coding silent	Stomach
COSM4603241	c.761_762insACCACC	p.P264_L265insPP	Insertion - In frame	Upper_aerodigestive_tract
COSM293752	c.3295delC	p.K1101fs*3	Deletion - Frameshift	Large_intestine
COSM707753	c.1941C>T	p.G647G	Substitution - coding silent	Lung
COSM3746460	c.751T>C	p.L251L	Substitution - coding silent	Liver
COSM4641110	c.712A>G	p.T238A	Substitution - Missense	Large_intestine
COSM4639005	c.2980G>A	p.V994M	Substitution - Missense	Large_intestine
COSM985386	c.4055C>T	p.A1352V	Substitution - Missense	Endometrium
COSM5755165	c.4922C>G	p.T1641R	Substitution - Missense	Large_intestine
COSM1387268	c.2950C>T	p.R984W	Substitution - Missense	Large_intestine
COSM985382	c.2253_2258delCACCAC	p.T761_T762delTT	Deletion - In frame	Upper_aerodigestive_tract
COSM88033	c.3466C>T	p.R1156*	Substitution - Nonsense	Skin
COSM232567	c.3409C>A	p.H1137N	Substitution - Missense	Skin
COSM2802640	c.4188C>T	p.F1396F	Substitution - coding silent	Liver
COSM4987392	c.2257A>G	p.T753A	Substitution - Missense	Soft_tissue
COSM6002798	c.4130A>G	p.Q1377R	Substitution - Missense	Prostate
COSM3755970	c.4044G>A	p.L1348L	Substitution - coding silent	Large_intestine
COSM2802564	c.791_792insACCACC	p.P264_L265insPP	Insertion - In frame	Thyroid
COSM2802615	c.2569G>A	p.A857T	Substitution - Missense	Stomach
COSM4987393	c.2258C>T	p.T753I	Substitution - Missense	Soft_tissue
COSM3755969	c.2172G>A	p.P724P	Substitution - coding silent	Large_intestine
COSM985377	c.752_753insACCACC	p.P264_L265insPP	Insertion - In frame	Thyroid
COSM3378377	c.496C>T	p.R166*	Substitution - Nonsense	Pancreas
COSM4070289	c.3580C>T	p.R1194W	Substitution - Missense	Stomach
COSM4603241	c.761_762insACCACC	p.P264_L265insPP	Insertion - In frame	Upper_aerodigestive_tract
COSM5725946	c.1172C>T	p.P391L	Substitution - Missense	Skin
COSM437697	c.753_761delACCACCACC	p.P262_P264delPPP	Deletion - In frame	Endometrium
COSM4987392	c.2257A>G	p.T753A	Substitution - Missense	Soft_tissue
COSM5982225	c.1537C>T	p.R513C	Substitution - Missense	Upper_aerodigestive_tract
COSM985385	c.3999C>A	p.D1333E	Substitution - Missense	Endometrium
COSM4416780	c.1782C>A	p.P594P	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM4496218	c.4707C>T	p.D1569D	Substitution - coding silent	Skin
COSM2802564	c.791_792insACCACC	p.P264_L265insPP	Insertion - In frame	Thyroid
COSM4917574	c.574C>T	p.R192W	Substitution - Missense	Liver
COSM4987392	c.2257A>G	p.T753A	Substitution - Missense	Soft_tissue
COSM5957508	c.3153_3154ins18	p.P1058_S1059insPSAPAP	Insertion - In frame	Thyroid
COSM1644701	c.1417T>C	p.C473R	Substitution - Missense	Salivary_gland
COSM5959281	c.2716C>G	p.P906A	Substitution - Missense	Thyroid
COSM3712467	c.3276G>T	p.L1092L	Substitution - coding silent	Upper_aerodigestive_tract
COSM4070281	c.380C>T	p.T127I	Substitution - Missense	Stomach
COSM4504756	c.673C>T	p.P225S	Substitution - Missense	Skin
COSM1679534	c.2446T>G	p.Y816D	Substitution - Missense	Large_intestine
COSM707751	c.2776G>A	p.E926K	Substitution - Missense	Lung
COSM985377	c.752_753insACCACC	p.P264_L265insPP	Insertion - In frame	Thyroid
COSM707754	c.1408C>G	p.P470A	Substitution - Missense	Lung
COSM1480123	c.2253_2255delCAC	p.T762delT	Deletion - In frame	Kidney
COSM2152632	c.3149C>T	p.P1050L	Substitution - Missense	Central_nervous_system
COSM3523216	c.2600C>T	p.S867L	Substitution - Missense	Skin
COSM4639004	c.2287G>A	p.A763T	Substitution - Missense	Large_intestine
COSM5559608	c.1375C>A	p.L459I	Substitution - Missense	Prostate
COSM2802572	c.1018C>T	p.R340C	Substitution - Missense	Large_intestine
COSM3717729	c.2068A>T	p.I690F	Substitution - Missense	Liver
COSM4603241	c.761_762insACCACC	p.P264_L265insPP	Insertion - In frame	Upper_aerodigestive_tract
COSM985384	c.3737G>A	p.R1246H	Substitution - Missense	Endometrium
COSM88033	c.3466C>T	p.R1156*	Substitution - Nonsense	Central_nervous_system
COSM4070287	c.3294G>C	p.G1098G	Substitution - coding silent	Stomach
COSM211589	c.4432T>G	p.C1478G	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5988170	c.4181A>G	p.N1394S	Substitution - Missense	Salivary_gland
COSM4617821	c.486C>T	p.S162S	Substitution - coding silent	Large_intestine
COSM5134900	c.3075C>T	p.S1025S	Substitution - coding silent	Large_intestine
COSM4603241	c.761_762insACCACC	p.P264_L265insPP	Insertion - In frame	Upper_aerodigestive_tract
COSM707756	c.1196G>C	p.S399T	Substitution - Missense	Thyroid
COSM4070283	c.1077C>T	p.D359D	Substitution - coding silent	Stomach
COSM4448916	c.1434delC	p.P480fs*7	Deletion - Frameshift	Skin
COSM3523215	c.2598C>T	p.S866S	Substitution - coding silent	Skin
COSM4515361	c.1065_1066CC>TT	p.P356S	Substitution - Missense	Skin
COSM4466259	c.1423C>T	p.R475C	Substitution - Missense	Skin
COSM4070291	c.3787C>T	p.R1263W	Substitution - Missense	Stomach
COSM2802651	c.4734C>T	p.C1578C	Substitution - coding silent	Large_intestine
COSM985389	c.4729G>A	p.E1577K	Substitution - Missense	Endometrium
COSM2802557	c.553A>G	p.K185E	Substitution - Missense	Oesophagus
COSM5747814	c.3753G>C	p.Q1251H	Substitution - Missense	Pancreas
COSM3362397	c.4078G>T	p.G1360C	Substitution - Missense	Kidney
COSM1387262	c.1259C>A	p.P420H	Substitution - Missense	Large_intestine
COSM4070279	c.304C>T	p.R102W	Substitution - Missense	Stomach
COSM460185	c.2412C>G	p.L804L	Substitution - coding silent	Cervix
COSM2802564	c.791_792insACCACC	p.P264_L265insPP	Insertion - In frame	Thyroid
COSM1387270	c.3727G>A	p.V1243M	Substitution - Missense	Large_intestine
COSM3970416	c.3299C>A	p.P1100H	Substitution - Missense	Central_nervous_system
COSM4603241	c.761_762insACCACC	p.P264_L265insPP	Insertion - In frame	Upper_aerodigestive_tract
COSM4847947	c.982C>T	p.R328W	Substitution - Missense	Cervix
COSM3523221	c.4533C>T	p.I1511I	Substitution - coding silent	Skin
COSM985382	c.2253_2258delCACCAC	p.T761_T762delTT	Deletion - In frame	Prostate
COSM3691899	c.4697G>A	p.R1566H	Substitution - Missense	Large_intestine
COSM473480	c.2635G>T	p.A879S	Substitution - Missense	Upper_aerodigestive_tract
COSM4987393	c.2258C>T	p.T753I	Substitution - Missense	Soft_tissue
COSM1303429	c.644C>T	p.S215L	Substitution - Missense	Urinary_tract
COSM2802632	c.3377G>A	p.R1126Q	Substitution - Missense	Soft_tissue
COSM5019544	c.234A>G	p.P78P	Substitution - coding silent	Soft_tissue
COSM437697	c.753_761delACCACCACC	p.P262_P264delPPP	Deletion - In frame	Upper_aerodigestive_tract
COSM3362396	c.3652C>A	p.L1218M	Substitution - Missense	Kidney
COSM3755970	c.4044G>A	p.L1348L	Substitution - coding silent	Large_intestine
COSM4987391	c.2254A>G	p.T752A	Substitution - Missense	Soft_tissue
COSM3755969	c.2172G>A	p.P724P	Substitution - coding silent	Breast
COSM4603241	c.761_762insACCACC	p.P264_L265insPP	Insertion - In frame	Upper_aerodigestive_tract
COSM4580201	c.2559G>A	p.A853A	Substitution - coding silent	Bone
COSM4987392	c.2257A>G	p.T753A	Substitution - Missense	Soft_tissue
COSM3728132	c.4174G>T	p.E1392*	Substitution - Nonsense	Haematopoietic_and_lymphoid_tissue
COSM4070280	c.339T>C	p.L113L	Substitution - coding silent	Stomach
COSM985383	c.3503C>A	p.P1168Q	Substitution - Missense	Endometrium
COSM473480	c.2635G>T	p.A879S	Substitution - Missense	Upper_aerodigestive_tract
COSM4130750	c.2145C>T	p.H715H	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM4070288	c.3337G>A	p.G1113S	Substitution - Missense	Stomach
COSM5559608	c.1375C>A	p.L459I	Substitution - Missense	Prostate
COSM3523214	c.2513C>T	p.S838F	Substitution - Missense	Skin
COSM4188777	c.46delG	p.A16fs*7	Deletion - Frameshift	Kidney
COSM3523220	c.4370G>A	p.R1457Q	Substitution - Missense	Skin
COSM437699	c.4036G>A	p.E1346K	Substitution - Missense	Breast
COSM5387544	c.2236G>A	p.A746T	Substitution - Missense	Skin
COSM4603241	c.761_762insACCACC	p.P264_L265insPP	Insertion - In frame	Upper_aerodigestive_tract
COSM4949583	c.3458G>A	p.G1153E	Substitution - Missense	Liver
COSM5629546	c.4683C>A	p.I1561I	Substitution - coding silent	Oesophagus
COSM4474799	c.1942C>T	p.P648S	Substitution - Missense	Skin
COSM3958883	c.4334A>G	p.Y1445C	Substitution - Missense	Lung
COSM3523214	c.2513C>T	p.S838F	Substitution - Missense	Skin
COSM5808776	c.314C>T	p.A105V	Substitution - Missense	Liver
COSM4849319	c.4667G>T	p.R1556L	Substitution - Missense	Cervix
COSM4170848	c.2251G>A	p.V751I	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4070292	c.4696C>A	p.R1566S	Substitution - Missense	Stomach
COSM5364094	c.3487G>A	p.A1163T	Substitution - Missense	Large_intestine
COSM1255503	c.985C>T	p.L329L	Substitution - coding silent	Oesophagus
COSM5485919	c.2867C>T	p.A956V	Substitution - Missense	Large_intestine
COSM4130749	c.807T>C	p.A269A	Substitution - coding silent	Thyroid
COSM707756	c.1196G>C	p.S399T	Substitution - Missense	Lung
COSM4939227	c.3227A>G	p.E1076G	Substitution - Missense	Liver
COSM5599760	c.3860C>T	p.S1287F	Substitution - Missense	Skin
COSM1387264	c.1531delC	p.R513fs*69	Deletion - Frameshift	Large_intestine
COSM4943507	c.3290A>T	p.E1097V	Substitution - Missense	Liver
COSM4650423	c.4897G>A	p.A1633T	Substitution - Missense	Large_intestine
COSM473480	c.2635G>T	p.A879S	Substitution - Missense	Kidney
COSM4130749	c.807T>C	p.A269A	Substitution - coding silent	Thyroid
COSM1522883	c.1231C>T	p.R411W	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM2802614	c.2546C>T	p.P849L	Substitution - Missense	Central_nervous_system
COSM3523219	c.4318A>G	p.I1440V	Substitution - Missense	Skin
COSM4949583	c.3458G>A	p.G1153E	Substitution - Missense	Liver
COSM1387259	c.161C>A	p.P54H	Substitution - Missense	Large_intestine
COSM3755970	c.4044G>A	p.L1348L	Substitution - coding silent	Thyroid
COSM985382	c.2253_2258delCACCAC	p.T761_T762delTT	Deletion - In frame	Upper_aerodigestive_tract
COSM3523216	c.2600C>T	p.S867L	Substitution - Missense	Skin
COSM3796177	c.2239C>G	p.P747A	Substitution - Missense	Urinary_tract
COSM4130749	c.807T>C	p.A269A	Substitution - coding silent	Thyroid
COSM985377	c.752_753insACCACC	p.P264_L265insPP	Insertion - In frame	Upper_aerodigestive_tract
COSM2802646	c.4548C>T	p.H1516H	Substitution - coding silent	Large_intestine
COSM1211802	c.355T>C	p.S119P	Substitution - Missense	Large_intestine
COSM4603241	c.761_762insACCACC	p.P264_L265insPP	Insertion - In frame	Upper_aerodigestive_tract
COSM985382	c.2253_2258delCACCAC	p.T761_T762delTT	Deletion - In frame	Oesophagus
COSM1679533	c.1033G>A	p.E345K	Substitution - Missense	Large_intestine
COSM473480	c.2635G>T	p.A879S	Substitution - Missense	Upper_aerodigestive_tract
COSM2802635	c.3626G>A	p.R1209Q	Substitution - Missense	Liver
COSM3691897	c.437G>A	p.R146H	Substitution - Missense	Thyroid
COSM3378378	c.2547G>A	p.P849P	Substitution - coding silent	Biliary_tract
COSM4443315	c.539T>C	p.L180P	Substitution - Missense	Large_intestine
COSM297759	c.1955delC	p.Q654fs*46	Deletion - Frameshift	Large_intestine
COSM5972469	c.147C>T	p.A49A	Substitution - coding silent	Upper_aerodigestive_tract
COSM4603241	c.761_762insACCACC	p.P264_L265insPP	Insertion - In frame	Upper_aerodigestive_tract
COSM365697	c.577G>A	p.G193R	Substitution - Missense	Lung
COSM985379	c.1245G>A	p.P415P	Substitution - coding silent	Endometrium
COSM5559608	c.1375C>A	p.L459I	Substitution - Missense	Prostate
COSM3958883	c.4334A>G	p.Y1445C	Substitution - Missense	Kidney
COSM473480	c.2635G>T	p.A879S	Substitution - Missense	Upper_aerodigestive_tract
COSM1610922	c.723C>T	p.P241P	Substitution - coding silent	Liver
COSM1211801	c.4186T>G	p.F1396V	Substitution - Missense	Large_intestine
COSM1387269	c.3245C>T	p.P1082L	Substitution - Missense	Large_intestine
COSM5055836	c.2519G>C	p.G840A	Substitution - Missense	Stomach
COSM473480	c.2635G>T	p.A879S	Substitution - Missense	Oesophagus
COSM3421983	c.2921G>A	p.R974Q	Substitution - Missense	Large_intestine
COSM5017374	c.782_783insACCACA	p.P262_P263insQP	Insertion - In frame	Soft_tissue
COSM2802618	c.2638C>G	p.R880G	Substitution - Missense	Large_intestine
COSM5599760	c.3860C>T	p.S1287F	Substitution - Missense	Skin
COSM4070286	c.1287G>A	p.A429A	Substitution - coding silent	Stomach
COSM1387267	c.2222delC	p.T743fs*39	Deletion - Frameshift	Large_intestine
COSM1387266	c.2154C>T	p.G718G	Substitution - coding silent	Large_intestine

> Text Mining based Variations

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PMID	Variation	Cancer	Evidence
23508829	Mutation	lymphoblastic Leukemia	Whole-exome- and whole-genome-sequencing of MHH-CALL-2 revealed homozygous non-synonymous coding mutations predicted to be deleterious for the protein function of 63 genes, among them known cancer-associated genes, such as FANCA, NF1, TCF7L2, CARD11, EP400, histone demethylases, and transferases (KDM6B, KDM1A, PRDM11).

Summary
Symbol	KDM6B
Name	lysine demethylase 6B
Aliases	KIAA0346; JMJD3; jumonji domain containing 3; jumonji domain containing 3, histone lysine demethylase; jmjC ......
Location	17p13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

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Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant

Summary
Symbol	KDM6B
Name	lysine demethylase 6B
Aliases	KIAA0346; JMJD3; jumonji domain containing 3; jumonji domain containing 3, histone lysine demethylase; jmjC ......
Location	17p13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

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Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	6.583	5.794	-1.017	3.19e-07	Under
BRCA	Breast invasive carcinoma	112	1100	5.661	5.459	-0.178	0.00134	NS
CESC	Cervical and endocervical cancers	3	306	6.285	5.312	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	6.107	5.618	-0.418	0.000201	NS
ESCA	Esophageal carcinoma	11	185	6.49	6.516	-0.104	0.68	NS
GBM	Glioblastoma multiforme	5	166	4.777	4.863	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	5.758	5.851	0.021	0.876	NS
KIRC	Kidney renal clear cell carcinoma	72	534	5.547	5.771	0.381	4.64e-05	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	6.035	6.155	0.042	0.745	NS
LAML	Acute Myeloid Leukemia	0	173	NA	6.752	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	5.635	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	5.164	4.152	-1.024	2.05e-19	Under
LUAD	Lung adenocarcinoma	59	517	6.206	5.817	-0.628	1.91e-09	Under
LUSC	Lung squamous cell carcinoma	51	501	6.403	5.709	-0.947	1.33e-16	Under
OV	Ovarian serous cystadenocarcinoma	0	307	NA	5.97	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	5.969	5.692	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	5.964	6.153	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	5.727	5.754	0.043	0.632	NS
READ	Rectum adenocarcinoma	10	167	5.662	5.587	-0.056	0.822	NS
SARC	Sarcoma	2	263	5.342	5.226	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	4.836	5.47	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	6.545	6.232	-0.195	0.096	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	5.582	NA	NA	NA
THCA	Thyroid carcinoma	59	509	5.829	5.594	-0.314	2.79e-06	NS
THYM	Thymoma	2	120	6.938	6.135	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	5.994	6.139	0.013	0.917	NS

> Cancer Cell Line Encyclopedia (CCLE)

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Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	6.2
Autonomic ganglia	CHP212	5.6
Autonomic ganglia	IMR32	6.5
Autonomic ganglia	KELLY	6.1
Autonomic ganglia	KPNRTBM1	6.6
Autonomic ganglia	KPNSI9S	5.6
Autonomic ganglia	KPNYN	5.8
Autonomic ganglia	MHHNB11	6.3
Autonomic ganglia	NB1	6.9
Autonomic ganglia	NH6	5.6
Autonomic ganglia	SHSY5Y	6.7
Autonomic ganglia	SIMA	7.1
Autonomic ganglia	SKNAS	5.5
Autonomic ganglia	SKNBE2	6
Autonomic ganglia	SKNDZ	6.2
Autonomic ganglia	SKNFI	6.1
Autonomic ganglia	SKNSH	5.3
Biliary tract	HUCCT1	5.2
Biliary tract	HUH28	5.8
Biliary tract	SNU1079	5.9
Biliary tract	SNU1196	6
Biliary tract	SNU245	5.7
Biliary tract	SNU308	5.6
Biliary tract	SNU478	5.5
Bone	143B	5.3
Bone	A673	5.6
Bone	CADOES1	6.2
Bone	CAL78	5.7
Bone	G292CLONEA141B1	6.2
Bone	HOS	5.3
Bone	HS706T	5.3
Bone	HS737T	5.3
Bone	HS819T	5.2
Bone	HS821T	5.7
Bone	HS822T	5.3
Bone	HS863T	5.2
Bone	HS870T	5.1
Bone	HS888T	5.7
Bone	MG63	5.3
Bone	MHHES1	7
Bone	OUMS27	5.4
Bone	RDES	6.1
Bone	SJSA1	5.1
Bone	SKES1	6.1
Bone	SKNMC	6
Bone	SW1353	5.4
Bone	T173	5.1
Bone	TC71	5.3
Bone	U2OS	5.6
Breast	AU565	6
Breast	BT20	6.3
Breast	BT474	6.1
Breast	BT483	6.4
Breast	BT549	5.9
Breast	CAL120	5.8
Breast	CAL148	7.4
Breast	CAL51	5.8
Breast	CAL851	5.8
Breast	CAMA1	5.5
Breast	DU4475	5.7
Breast	EFM192A	5.6
Breast	EFM19	5.7
Breast	EVSAT	5.7
Breast	HCC1143	5.5
Breast	HCC1187	6.1
Breast	HCC1395	5.9
Breast	HCC1419	5.9
Breast	HCC1428	5.6
Breast	HCC1500	5.5
Breast	HCC1569	5.9
Breast	HCC1599	5.6
Breast	HCC1806	6.1
Breast	HCC1937	5.4
Breast	HCC1954	5.5
Breast	HCC202	6.4
Breast	HCC2157	5.8
Breast	HCC2218	5.9
Breast	HCC38	5
Breast	HCC70	5.5
Breast	HDQP1	5.2
Breast	HMC18	5.8
Breast	HS274T	5.6
Breast	HS281T	5.3
Breast	HS343T	5.3
Breast	HS578T	6
Breast	HS606T	5.3
Breast	HS739T	5.2
Breast	HS742T	5.4
Breast	JIMT1	5.5
Breast	KPL1	6
Breast	MCF7	6
Breast	MDAMB134VI	5.6
Breast	MDAMB157	5.4
Breast	MDAMB175VII	5.4
Breast	MDAMB231	5.4
Breast	MDAMB361	6
Breast	MDAMB415	5.9
Breast	MDAMB436	6.3
Breast	MDAMB453	5.3
Breast	MDAMB468	5.6
Breast	SKBR3	6
Breast	T47D	5.2
Breast	UACC812	6.8
Breast	UACC893	6.4
Breast	YMB1	6
Breast	ZR751	5.6
Breast	ZR7530	5.7
Central nervous system	1321N1	5.2
Central nervous system	42MGBA	5.4
Central nervous system	8MGBA	5.3
Central nervous system	A172	5.6
Central nervous system	AM38	5.1
Central nervous system	BECKER	5.5
Central nervous system	CAS1	5.9
Central nervous system	CCFSTTG1	5.3
Central nervous system	D283MED	5.4
Central nervous system	D341MED	6.5
Central nervous system	DAOY	5.2
Central nervous system	DBTRG05MG	5.6
Central nervous system	DKMG	5.7
Central nervous system	GAMG	5
Central nervous system	GB1	6.2
Central nervous system	GI1	5.4
Central nervous system	GMS10	5
Central nervous system	GOS3	5.4
Central nervous system	H4	5.4
Central nervous system	HS683	5.4
Central nervous system	KALS1	5.3
Central nervous system	KG1C	5.4
Central nervous system	KNS42	5.4
Central nervous system	KNS60	5.6
Central nervous system	KNS81	5.2
Central nervous system	KS1	5.2
Central nervous system	LN18	5.7
Central nervous system	LN229	5.2
Central nervous system	M059K	5
Central nervous system	MOGGCCM	5.4
Central nervous system	MOGGUVW	5.6
Central nervous system	NMCG1	5.1
Central nervous system	ONS76	5.3
Central nervous system	SF126	5.6
Central nervous system	SF295	5.4
Central nervous system	SNB19	5.2
Central nervous system	SNU1105	5.7
Central nervous system	SNU201	5.6
Central nervous system	SNU466	6
Central nervous system	SNU489	6.3
Central nervous system	SNU626	5.4
Central nervous system	SNU738	5.5
Central nervous system	SW1088	5.5
Central nervous system	SW1783	5.3
Central nervous system	T98G	5.7
Central nervous system	TM31	6.2
Central nervous system	U118MG	5.7
Central nervous system	U138MG	5.4
Central nervous system	U251MG	5.6
Central nervous system	U87MG	5.5
Central nervous system	YH13	5
Central nervous system	YKG1	5.6
Endometrium	AN3CA	6.2
Endometrium	COLO684	6.5
Endometrium	EFE184	5.8
Endometrium	EN	5.8
Endometrium	ESS1	5.1
Endometrium	HEC108	6
Endometrium	HEC151	5.9
Endometrium	HEC1A	5.2
Endometrium	HEC1B	5.7
Endometrium	HEC251	5.5
Endometrium	HEC265	5.4
Endometrium	HEC50B	5.5
Endometrium	HEC59	5.3
Endometrium	HEC6	5.3
Endometrium	ISHIKAWAHERAKLIO02ER	5.5
Endometrium	JHUEM1	6.4
Endometrium	JHUEM2	5.4
Endometrium	JHUEM3	5.1
Endometrium	KLE	5.3
Endometrium	MFE280	5.7
Endometrium	MFE296	5.4
Endometrium	MFE319	6.3
Endometrium	RL952	5.6
Endometrium	SNGM	6.8
Endometrium	SNU1077	5.8
Endometrium	SNU685	6.2
Endometrium	TEN	5.3
Haematopoietic and lymphoid	697	6
Haematopoietic and lymphoid	A3KAW	5.9
Haematopoietic and lymphoid	A4FUK	5.9
Haematopoietic and lymphoid	ALLSIL	5.4
Haematopoietic and lymphoid	AML193	5.5
Haematopoietic and lymphoid	AMO1	5.7
Haematopoietic and lymphoid	BCP1	5.5
Haematopoietic and lymphoid	BDCM	5.6
Haematopoietic and lymphoid	BL41	5.8
Haematopoietic and lymphoid	BL70	5.9
Haematopoietic and lymphoid	BV173	6
Haematopoietic and lymphoid	CA46	7.1
Haematopoietic and lymphoid	CI1	5.7
Haematopoietic and lymphoid	CMK115	5.7
Haematopoietic and lymphoid	CMK86	6
Haematopoietic and lymphoid	CMK	6.1
Haematopoietic and lymphoid	CMLT1	7.4
Haematopoietic and lymphoid	COLO775	6
Haematopoietic and lymphoid	DAUDI	6
Haematopoietic and lymphoid	DB	5.7
Haematopoietic and lymphoid	DEL	7.1
Haematopoietic and lymphoid	DND41	6.4
Haematopoietic and lymphoid	DOHH2	6.6
Haematopoietic and lymphoid	EB1	6.9
Haematopoietic and lymphoid	EB2	6.4
Haematopoietic and lymphoid	EHEB	6.8
Haematopoietic and lymphoid	EJM	5.5
Haematopoietic and lymphoid	EM2	5.6
Haematopoietic and lymphoid	EOL1	6.5
Haematopoietic and lymphoid	F36P	6.7
Haematopoietic and lymphoid	GA10	5.7
Haematopoietic and lymphoid	GDM1	5.6
Haematopoietic and lymphoid	GRANTA519	5.8
Haematopoietic and lymphoid	HDLM2	5.5
Haematopoietic and lymphoid	HDMYZ	5.4
Haematopoietic and lymphoid	HEL9217	5.5
Haematopoietic and lymphoid	HEL	6.2
Haematopoietic and lymphoid	HH	5.7
Haematopoietic and lymphoid	HL60	6.4
Haematopoietic and lymphoid	HPBALL	6.9
Haematopoietic and lymphoid	HS604T	5.7
Haematopoietic and lymphoid	HS611T	5.5
Haematopoietic and lymphoid	HS616T	5.3
Haematopoietic and lymphoid	HS751T	5.3
Haematopoietic and lymphoid	HT	5.8
Haematopoietic and lymphoid	HTK	5.7
Haematopoietic and lymphoid	HUNS1	5.8
Haematopoietic and lymphoid	HUT102	6
Haematopoietic and lymphoid	HUT78	5.3
Haematopoietic and lymphoid	JEKO1	6.1
Haematopoietic and lymphoid	JK1	6.6
Haematopoietic and lymphoid	JM1	5.7
Haematopoietic and lymphoid	JURKAT	6.9
Haematopoietic and lymphoid	JURLMK1	6.8
Haematopoietic and lymphoid	JVM2	6.9
Haematopoietic and lymphoid	JVM3	6.8
Haematopoietic and lymphoid	K562	6.5
Haematopoietic and lymphoid	KARPAS299	6.5
Haematopoietic and lymphoid	KARPAS422	7.2
Haematopoietic and lymphoid	KARPAS620	5.5
Haematopoietic and lymphoid	KASUMI1	5.5
Haematopoietic and lymphoid	KASUMI2	5.5
Haematopoietic and lymphoid	KASUMI6	5.7
Haematopoietic and lymphoid	KCL22	6
Haematopoietic and lymphoid	KE37	6.2
Haematopoietic and lymphoid	KE97	5.3
Haematopoietic and lymphoid	KG1	5.2
Haematopoietic and lymphoid	KHM1B	5.9
Haematopoietic and lymphoid	KIJK	5.6
Haematopoietic and lymphoid	KMH2	5.7
Haematopoietic and lymphoid	KMM1	5.7
Haematopoietic and lymphoid	KMS11	5.3
Haematopoietic and lymphoid	KMS12BM	5.6
Haematopoietic and lymphoid	KMS18	5.9
Haematopoietic and lymphoid	KMS20	5.8
Haematopoietic and lymphoid	KMS21BM	5.7
Haematopoietic and lymphoid	KMS26	5.4
Haematopoietic and lymphoid	KMS27	5.5
Haematopoietic and lymphoid	KMS28BM	5.4
Haematopoietic and lymphoid	KMS34	5.6
Haematopoietic and lymphoid	KO52	5.7
Haematopoietic and lymphoid	KOPN8	5.9
Haematopoietic and lymphoid	KU812	5.8
Haematopoietic and lymphoid	KYO1	6.5
Haematopoietic and lymphoid	L1236	5.6
Haematopoietic and lymphoid	L363	6.2
Haematopoietic and lymphoid	L428	5.9
Haematopoietic and lymphoid	L540	5.9
Haematopoietic and lymphoid	LAMA84	6.8
Haematopoietic and lymphoid	LOUCY	5.8
Haematopoietic and lymphoid	LP1	6.7
Haematopoietic and lymphoid	M07E	7.3
Haematopoietic and lymphoid	MC116	6.1
Haematopoietic and lymphoid	ME1	5.9
Haematopoietic and lymphoid	MEC1	5.2
Haematopoietic and lymphoid	MEC2	5.6
Haematopoietic and lymphoid	MEG01	6.1
Haematopoietic and lymphoid	MHHCALL2	5.5
Haematopoietic and lymphoid	MHHCALL3	5.7
Haematopoietic and lymphoid	MHHCALL4	5.7
Haematopoietic and lymphoid	MINO	6.5
Haematopoietic and lymphoid	MJ	5.5
Haematopoietic and lymphoid	MM1S	5.5
Haematopoietic and lymphoid	MOLM13	6.2
Haematopoietic and lymphoid	MOLM16	7
Haematopoietic and lymphoid	MOLM6	6.1
Haematopoietic and lymphoid	MOLP2	5.4
Haematopoietic and lymphoid	MOLP8	6.3
Haematopoietic and lymphoid	MOLT13	6.2
Haematopoietic and lymphoid	MOLT16	7
Haematopoietic and lymphoid	MOLT4	5.5
Haematopoietic and lymphoid	MONOMAC1	5.5
Haematopoietic and lymphoid	MONOMAC6	5.9
Haematopoietic and lymphoid	MOTN1	5.3
Haematopoietic and lymphoid	MUTZ5	6
Haematopoietic and lymphoid	MV411	6.3
Haematopoietic and lymphoid	NALM19	5.5
Haematopoietic and lymphoid	NALM1	6.4
Haematopoietic and lymphoid	NALM6	6.5
Haematopoietic and lymphoid	NAMALWA	6.5
Haematopoietic and lymphoid	NB4	5.6
Haematopoietic and lymphoid	NCIH929	5.7
Haematopoietic and lymphoid	NCO2	5.9
Haematopoietic and lymphoid	NOMO1	5.7
Haematopoietic and lymphoid	NUDHL1	7.6
Haematopoietic and lymphoid	NUDUL1	6.1
Haematopoietic and lymphoid	OCIAML2	6.2
Haematopoietic and lymphoid	OCIAML3	6.8
Haematopoietic and lymphoid	OCIAML5	5.6
Haematopoietic and lymphoid	OCILY10	6.2
Haematopoietic and lymphoid	OCILY19	7.1
Haematopoietic and lymphoid	OCILY3	5.6
Haematopoietic and lymphoid	OCIM1	7.1
Haematopoietic and lymphoid	OPM2	6.6
Haematopoietic and lymphoid	P12ICHIKAWA	6.1
Haematopoietic and lymphoid	P31FUJ	5.5
Haematopoietic and lymphoid	P3HR1	6
Haematopoietic and lymphoid	PCM6	5.5
Haematopoietic and lymphoid	PEER	5.5
Haematopoietic and lymphoid	PF382	6.4
Haematopoietic and lymphoid	PFEIFFER	5.5
Haematopoietic and lymphoid	PL21	6.2
Haematopoietic and lymphoid	RAJI	5.9
Haematopoietic and lymphoid	RCHACV	6.1
Haematopoietic and lymphoid	REC1	8
Haematopoietic and lymphoid	REH	5.7
Haematopoietic and lymphoid	RI1	6.7
Haematopoietic and lymphoid	RL	5.7
Haematopoietic and lymphoid	RPMI8226	5.4
Haematopoietic and lymphoid	RPMI8402	6
Haematopoietic and lymphoid	RS411	5.6
Haematopoietic and lymphoid	SEM	5.6
Haematopoietic and lymphoid	SET2	6.2
Haematopoietic and lymphoid	SIGM5	6.4
Haematopoietic and lymphoid	SKM1	5.3
Haematopoietic and lymphoid	SKMM2	5.8
Haematopoietic and lymphoid	SR786	6.6
Haematopoietic and lymphoid	ST486	5.7
Haematopoietic and lymphoid	SUDHL10	6.7
Haematopoietic and lymphoid	SUDHL1	6.8
Haematopoietic and lymphoid	SUDHL4	7.2
Haematopoietic and lymphoid	SUDHL5	6.8
Haematopoietic and lymphoid	SUDHL6	6.2
Haematopoietic and lymphoid	SUDHL8	6.1
Haematopoietic and lymphoid	SUPB15	5.8
Haematopoietic and lymphoid	SUPHD1	6.6
Haematopoietic and lymphoid	SUPM2	6
Haematopoietic and lymphoid	SUPT11	6.1
Haematopoietic and lymphoid	SUPT1	6
Haematopoietic and lymphoid	TALL1	7.1
Haematopoietic and lymphoid	TF1	6
Haematopoietic and lymphoid	THP1	5.2
Haematopoietic and lymphoid	TO175T	5.6
Haematopoietic and lymphoid	TOLEDO	5.3
Haematopoietic and lymphoid	U266B1	5.3
Haematopoietic and lymphoid	U937	5.8
Haematopoietic and lymphoid	UT7	6.1
Haematopoietic and lymphoid	WSUDLCL2	6.9
Kidney	769P	5.7
Kidney	786O	5.4
Kidney	A498	5.6
Kidney	A704	5.3
Kidney	ACHN	5.3
Kidney	BFTC909	5.8
Kidney	CAKI1	5.4
Kidney	CAKI2	4.9
Kidney	CAL54	6.3
Kidney	KMRC1	5.2
Kidney	KMRC20	5.1
Kidney	KMRC2	5.6
Kidney	KMRC3	5.6
Kidney	OSRC2	5.6
Kidney	RCC10RGB	5.2
Kidney	SNU1272	5.2
Kidney	SNU349	6
Kidney	TUHR10TKB	5.4
Kidney	TUHR14TKB	5.6
Kidney	TUHR4TKB	5.3
Kidney	VMRCRCW	5.7
Kidney	VMRCRCZ	5.4
Large intestine	C2BBE1	5.3
Large intestine	CCK81	6
Large intestine	CL11	5.4
Large intestine	CL14	5.6
Large intestine	CL34	6.2
Large intestine	CL40	6.2
Large intestine	COLO205	5.5
Large intestine	COLO320	6.1
Large intestine	COLO678	5.6
Large intestine	CW2	5.8
Large intestine	DLD1	5.3
Large intestine	GP2D	5.8
Large intestine	HCC56	6.1
Large intestine	HCT116	5.5
Large intestine	HCT15	5.3
Large intestine	HS675T	5.4
Large intestine	HS698T	5.4
Large intestine	HT115	6.2
Large intestine	HT29	5.6
Large intestine	HT55	5.6
Large intestine	KM12	6.2
Large intestine	LOVO	5.4
Large intestine	LS1034	5.6
Large intestine	LS123	5.6
Large intestine	LS180	5.7
Large intestine	LS411N	5.6
Large intestine	LS513	5.7
Large intestine	MDST8	5.7
Large intestine	NCIH508	6.1
Large intestine	NCIH716	5.5
Large intestine	NCIH747	5.3
Large intestine	OUMS23	6.7
Large intestine	RCM1	5.6
Large intestine	RKO	6.2
Large intestine	SKCO1	6.1
Large intestine	SNU1040	6.2
Large intestine	SNU1197	5.4
Large intestine	SNU175	5.8
Large intestine	SNU283	5.6
Large intestine	SNU407	5.9
Large intestine	SNU503	6.2
Large intestine	SNU61	5.7
Large intestine	SNU81	6.7
Large intestine	SNUC1	6
Large intestine	SNUC2A	5.4
Large intestine	SNUC4	6
Large intestine	SNUC5	5.7
Large intestine	SW1116	6
Large intestine	SW1417	5.5
Large intestine	SW1463	5.9
Large intestine	SW403	5.6
Large intestine	SW480	5.4
Large intestine	SW48	6
Large intestine	SW620	5.7
Large intestine	SW837	5.2
Large intestine	SW948	5.6
Large intestine	T84	6.4
Liver	ALEXANDERCELLS	5.6
Liver	C3A	5.8
Liver	HEP3B217	5.9
Liver	HEPG2	5.7
Liver	HLE	5.2
Liver	HLF	5.5
Liver	HUH1	5.6
Liver	HUH6	6
Liver	HUH7	5.6
Liver	JHH1	5.4
Liver	JHH2	5.9
Liver	JHH4	5.3
Liver	JHH5	5.7
Liver	JHH6	5.7
Liver	JHH7	5.9
Liver	LI7	5.3
Liver	PLCPRF5	5.9
Liver	SKHEP1	5.3
Liver	SNU182	5.9
Liver	SNU387	5.5
Liver	SNU398	5.6
Liver	SNU423	5.3
Liver	SNU449	5.5
Liver	SNU475	5.6
Liver	SNU761	5.9
Liver	SNU878	5.4
Liver	SNU886	5.7
Lung	A549	5.4
Lung	ABC1	5.3
Lung	BEN	6.9
Lung	CAL12T	5.3
Lung	CALU1	5.3
Lung	CALU3	5.6
Lung	CALU6	5.9
Lung	CHAGOK1	5.5
Lung	COLO668	5.8
Lung	COLO699	5.2
Lung	CORL105	5.3
Lung	CORL23	6.2
Lung	CORL24	7.3
Lung	CORL279	7.5
Lung	CORL311	7.1
Lung	CORL47	5.7
Lung	CORL51	7.1
Lung	CORL88	5.7
Lung	CORL95	5.8
Lung	CPCN	5.7
Lung	DMS114	5.7
Lung	DMS153	5.6
Lung	DMS273	6
Lung	DMS454	5.7
Lung	DMS53	6.2
Lung	DMS79	5.8
Lung	DV90	5.9
Lung	EBC1	5.7
Lung	EPLC272H	6
Lung	HARA	5.4
Lung	HCC1171	5.2
Lung	HCC1195	6.7
Lung	HCC15	5.3
Lung	HCC2279	5.2
Lung	HCC2935	6.5
Lung	HCC33	6.2
Lung	HCC366	5.2
Lung	HCC4006	5.9
Lung	HCC44	6.1
Lung	HCC78	5.1
Lung	HCC827	6
Lung	HCC95	5.3
Lung	HLC1	6.3
Lung	HLFA	5.2
Lung	HS229T	5.1
Lung	HS618T	5.2
Lung	IALM	5.7
Lung	KNS62	5.5
Lung	LC1F	5.6
Lung	LC1SQSF	5.2
Lung	LCLC103H	5.6
Lung	LCLC97TM1	6.1
Lung	LK2	5.8
Lung	LOUNH91	5.6
Lung	LU65	5.5
Lung	LU99	5.2
Lung	LUDLU1	5.4
Lung	LXF289	5.7
Lung	MORCPR	6.1
Lung	NCIH1048	5.7
Lung	NCIH1092	5.7
Lung	NCIH1105	6.7
Lung	NCIH1155	5.5
Lung	NCIH1184	6.2
Lung	NCIH1299	5.6
Lung	NCIH1339	5.9
Lung	NCIH1341	5.4
Lung	NCIH1355	5.1
Lung	NCIH1373	5.7
Lung	NCIH1385	7.9
Lung	NCIH1395	5.4
Lung	NCIH1435	5.8
Lung	NCIH1436	6.7
Lung	NCIH1437	5.5
Lung	NCIH146	5.7
Lung	NCIH1563	5.7
Lung	NCIH1568	5.5
Lung	NCIH1573	5.8
Lung	NCIH1581	5.8
Lung	NCIH1618	6
Lung	NCIH1623	5.7
Lung	NCIH1648	5.8
Lung	NCIH1650	5.7
Lung	NCIH1651	5.3
Lung	NCIH1666	5.5
Lung	NCIH1693	5.2
Lung	NCIH1694	5.9
Lung	NCIH1703	5.6
Lung	NCIH1734	5.3
Lung	NCIH1755	5.2
Lung	NCIH1781	5.7
Lung	NCIH1792	5
Lung	NCIH1793	5.6
Lung	NCIH1836	6
Lung	NCIH1838	5.8
Lung	NCIH1869	5.6
Lung	NCIH1876	6.5
Lung	NCIH1915	5.6
Lung	NCIH1930	5.8
Lung	NCIH1944	5.2
Lung	NCIH1963	6.1
Lung	NCIH196	5.1
Lung	NCIH1975	5.7
Lung	NCIH2009	5.6
Lung	NCIH2023	5.4
Lung	NCIH2029	6
Lung	NCIH2030	5.4
Lung	NCIH2066	6.6
Lung	NCIH2081	6
Lung	NCIH2085	5.4
Lung	NCIH2087	5.7
Lung	NCIH209	5.8
Lung	NCIH2106	5.5
Lung	NCIH2110	5.8
Lung	NCIH211	5.5
Lung	NCIH2122	5.9
Lung	NCIH2126	5.8
Lung	NCIH2141	6.1
Lung	NCIH2170	5.8
Lung	NCIH2171	6.3
Lung	NCIH2172	5.1
Lung	NCIH2196	5.4
Lung	NCIH2227	6.2
Lung	NCIH2228	4.8
Lung	NCIH226	5.2
Lung	NCIH2286	5.3
Lung	NCIH2291	5.3
Lung	NCIH2342	5.3
Lung	NCIH2347	5.3
Lung	NCIH23	5.9
Lung	NCIH2405	5.3
Lung	NCIH2444	6.4
Lung	NCIH292	5.8
Lung	NCIH322	5.8
Lung	NCIH3255	6.3
Lung	NCIH358	5.9
Lung	NCIH441	5.9
Lung	NCIH446	5.9
Lung	NCIH460	5.5
Lung	NCIH510	6
Lung	NCIH520	5.2
Lung	NCIH522	5.5
Lung	NCIH524	5.4
Lung	NCIH526	6.3
Lung	NCIH596	5.8
Lung	NCIH647	5.1
Lung	NCIH650	6.3
Lung	NCIH661	5.7
Lung	NCIH69	5.4
Lung	NCIH727	6.1
Lung	NCIH810	6.3
Lung	NCIH82	6.1
Lung	NCIH838	5.1
Lung	NCIH841	6.2
Lung	NCIH854	6.5
Lung	NCIH889	5.9
Lung	PC14	5.8
Lung	RERFLCAD1	5.2
Lung	RERFLCAD2	5.5
Lung	RERFLCAI	5.2
Lung	RERFLCKJ	5.9
Lung	RERFLCMS	5.5
Lung	RERFLCSQ1	5.2
Lung	SBC5	5.8
Lung	SCLC21H	5.9
Lung	SHP77	6.3
Lung	SKLU1	5.3
Lung	SKMES1	5.4
Lung	SQ1	5.9
Lung	SW1271	5.4
Lung	SW1573	5.7
Lung	SW900	6.2
Lung	VMRCLCD	6.8
Lung	VMRCLCP	5.7
Oesophagus	COLO680N	6.4
Oesophagus	ECGI10	6.8
Oesophagus	KYSE140	5.9
Oesophagus	KYSE150	6.5
Oesophagus	KYSE180	5.9
Oesophagus	KYSE270	5.9
Oesophagus	KYSE30	6.4
Oesophagus	KYSE410	5.6
Oesophagus	KYSE450	6.2
Oesophagus	KYSE510	5.7
Oesophagus	KYSE520	5.7
Oesophagus	KYSE70	5.9
Oesophagus	OE19	6.2
Oesophagus	OE33	5.2
Oesophagus	TE10	6.1
Oesophagus	TE11	5.5
Oesophagus	TE14	6.1
Oesophagus	TE15	5.5
Oesophagus	TE1	5.2
Oesophagus	TE4	5.9
Oesophagus	TE5	5.7
Oesophagus	TE6	5.6
Oesophagus	TE8	5.5
Oesophagus	TE9	5.7
Oesophagus	TT	6.4
Ovary	59M	5.6
Ovary	A2780	6.2
Ovary	CAOV3	5.3
Ovary	CAOV4	6
Ovary	COLO704	5.8
Ovary	COV318	5.6
Ovary	COV362	5.1
Ovary	COV434	6.1
Ovary	COV504	5.2
Ovary	COV644	5.6
Ovary	EFO21	6
Ovary	EFO27	5.8
Ovary	ES2	5.3
Ovary	FUOV1	5.3
Ovary	HEYA8	5.2
Ovary	HS571T	5.3
Ovary	IGROV1	5.9
Ovary	JHOC5	5.6
Ovary	JHOM1	6.1
Ovary	JHOM2B	5.7
Ovary	JHOS2	5.3
Ovary	JHOS4	5.5
Ovary	KURAMOCHI	6.9
Ovary	MCAS	5.8
Ovary	NIHOVCAR3	6.1
Ovary	OAW28	5.1
Ovary	OAW42	5.5
Ovary	OC314	5.5
Ovary	OC316	5.5
Ovary	ONCODG1	6
Ovary	OV56	6.1
Ovary	OV7	5.1
Ovary	OV90	6.1
Ovary	OVCAR4	5.6
Ovary	OVCAR8	5.1
Ovary	OVISE	5.7
Ovary	OVK18	6.5
Ovary	OVKATE	5.1
Ovary	OVMANA	5.7
Ovary	OVSAHO	5.2
Ovary	OVTOKO	5.5
Ovary	RMGI	5.7
Ovary	RMUGS	5.1
Ovary	SKOV3	5.2
Ovary	SNU119	5.2
Ovary	SNU840	5.4
Ovary	SNU8	5.4
Ovary	TOV112D	6.2
Ovary	TOV21G	5.9
Ovary	TYKNU	5.5
Pancreas	ASPC1	5.9
Pancreas	BXPC3	5.3
Pancreas	CAPAN1	5.6
Pancreas	CAPAN2	5.3
Pancreas	CFPAC1	5.6
Pancreas	DANG	5.4
Pancreas	HPAC	6.1
Pancreas	HPAFII	6.1
Pancreas	HS766T	5.1
Pancreas	HUPT3	5.3
Pancreas	HUPT4	5.4
Pancreas	KCIMOH1	5.6
Pancreas	KLM1	6.5
Pancreas	KP2	5.4
Pancreas	KP3	5.7
Pancreas	KP4	5.8
Pancreas	L33	5.1
Pancreas	MIAPACA2	5.7
Pancreas	PANC0203	5.8
Pancreas	PANC0213	5.8
Pancreas	PANC0327	5.4
Pancreas	PANC0403	5.3
Pancreas	PANC0504	5.7
Pancreas	PANC0813	5.8
Pancreas	PANC1005	5.3
Pancreas	PANC1	5.3
Pancreas	PATU8902	5.3
Pancreas	PATU8988S	5.4
Pancreas	PATU8988T	5.3
Pancreas	PK1	5.7
Pancreas	PK45H	5.4
Pancreas	PK59	5.8
Pancreas	PL45	5.2
Pancreas	PSN1	5.8
Pancreas	QGP1	7
Pancreas	SNU213	5.6
Pancreas	SNU324	6.1
Pancreas	SNU410	5.5
Pancreas	SU8686	6
Pancreas	SUIT2	5.2
Pancreas	SW1990	4.9
Pancreas	T3M4	5.4
Pancreas	TCCPAN2	5.4
Pancreas	YAPC	5.7
Pleura	ACCMESO1	5.3
Pleura	DM3	5.5
Pleura	ISTMES1	5.3
Pleura	ISTMES2	5.3
Pleura	JL1	5.8
Pleura	MPP89	5.4
Pleura	MSTO211H	5.5
Pleura	NCIH2052	5
Pleura	NCIH2452	5.3
Pleura	NCIH28	5.4
Prostate	22RV1	6.3
Prostate	DU145	5.1
Prostate	LNCAPCLONEFGC	6.5
Prostate	MDAPCA2B	6.4
Prostate	NCIH660	5.6
Prostate	PC3	5.4
Prostate	VCAP	5.6
Salivary gland	A253	5.8
Salivary gland	YD15	5.3
Skin	A101D	5.5
Skin	A2058	5.7
Skin	A375	5.9
Skin	C32	5.7
Skin	CHL1	5.6
Skin	CJM	6.5
Skin	COLO679	5.3
Skin	COLO741	5.5
Skin	COLO783	5.9
Skin	COLO792	5.5
Skin	COLO800	5.7
Skin	COLO818	5.4
Skin	COLO829	6.1
Skin	COLO849	5.9
Skin	G361	5.1
Skin	GRM	6.4
Skin	HMCB	5.4
Skin	HS294T	5.8
Skin	HS600T	5.2
Skin	HS688AT	5.2
Skin	HS695T	5.5
Skin	HS839T	5.3
Skin	HS852T	5.6
Skin	HS895T	5.4
Skin	HS934T	5.3
Skin	HS936T	5.3
Skin	HS939T	5.4
Skin	HS940T	5.3
Skin	HS944T	5.6
Skin	HT144	5.7
Skin	IGR1	6.2
Skin	IGR37	5.6
Skin	IGR39	5.4
Skin	IPC298	5.1
Skin	K029AX	5.6
Skin	LOXIMVI	5.8
Skin	MALME3M	5.5
Skin	MDAMB435S	5.3
Skin	MELHO	5.3
Skin	MELJUSO	5.4
Skin	MEWO	5.4
Skin	RPMI7951	5.2
Skin	RVH421	5.6
Skin	SH4	5.9
Skin	SKMEL1	5.3
Skin	SKMEL24	5.4
Skin	SKMEL28	5.3
Skin	SKMEL2	5.2
Skin	SKMEL30	5.2
Skin	SKMEL31	5.8
Skin	SKMEL3	5.8
Skin	SKMEL5	5.6
Skin	UACC257	5.5
Skin	UACC62	6
Skin	WM115	5.7
Skin	WM1799	5.5
Skin	WM2664	5.4
Skin	WM793	6.5
Skin	WM88	5.7
Skin	WM983B	5.7
Small intestine	HUTU80	6.2
Soft tissue	A204	5.4
Soft tissue	G401	5.6
Soft tissue	G402	5.6
Soft tissue	GCT	5.3
Soft tissue	HS729	5.6
Soft tissue	HT1080	5.2
Soft tissue	KYM1	6
Soft tissue	MESSA	5.7
Soft tissue	RD	5.5
Soft tissue	RH30	6.2
Soft tissue	RH41	6
Soft tissue	RKN	5.6
Soft tissue	S117	5.5
Soft tissue	SJRH30	6.1
Soft tissue	SKLMS1	5.5
Soft tissue	SKUT1	5.4
Soft tissue	TE125T	5.3
Soft tissue	TE159T	5.4
Soft tissue	TE441T	6
Soft tissue	TE617T	6
Stomach	2313287	6.3
Stomach	AGS	5.8
Stomach	AZ521	6.2
Stomach	ECC10	7.2
Stomach	ECC12	5.4
Stomach	FU97	5.3
Stomach	GCIY	5.4
Stomach	GSS	6.7
Stomach	GSU	6.3
Stomach	HGC27	5.3
Stomach	HS746T	5.6
Stomach	HUG1N	5.5
Stomach	IM95	5.6
Stomach	KATOIII	5.7
Stomach	KE39	5.4
Stomach	LMSU	5.5
Stomach	MKN1	5.5
Stomach	MKN45	6.3
Stomach	MKN74	6.3
Stomach	MKN7	5.2
Stomach	NCCSTCK140	6.4
Stomach	NCIN87	5.5
Stomach	NUGC2	6.3
Stomach	NUGC3	5.4
Stomach	NUGC4	5.9
Stomach	OCUM1	5.8
Stomach	RERFGC1B	5.2
Stomach	SH10TC	5.4
Stomach	SNU16	5.6
Stomach	SNU1	5.5
Stomach	SNU216	5.8
Stomach	SNU520	6.6
Stomach	SNU5	5.2
Stomach	SNU601	6.3
Stomach	SNU620	5.5
Stomach	SNU668	6.1
Stomach	SNU719	6.2
Stomach	TGBC11TKB	6.3
Thyroid	8305C	5.5
Thyroid	8505C	5.3
Thyroid	BCPAP	6.7
Thyroid	BHT101	6
Thyroid	CAL62	5.4
Thyroid	CGTHW1	5.5
Thyroid	FTC133	5.4
Thyroid	FTC238	5.3
Thyroid	ML1	5.4
Thyroid	SW579	5.3
Thyroid	TT2609C02	5.3
Thyroid	TT	6.4
Upper aerodigestive tract	BHY	5.4
Upper aerodigestive tract	BICR16	6.6
Upper aerodigestive tract	BICR18	6.5
Upper aerodigestive tract	BICR22	6.4
Upper aerodigestive tract	BICR31	5.8
Upper aerodigestive tract	BICR56	6.6
Upper aerodigestive tract	BICR6	5.9
Upper aerodigestive tract	CAL27	5.9
Upper aerodigestive tract	CAL33	6.9
Upper aerodigestive tract	DETROIT562	5.4
Upper aerodigestive tract	FADU	5.8
Upper aerodigestive tract	HS840T	5.2
Upper aerodigestive tract	HSC2	5.8
Upper aerodigestive tract	HSC3	5.3
Upper aerodigestive tract	HSC4	6
Upper aerodigestive tract	PECAPJ15	5.9
Upper aerodigestive tract	PECAPJ34CLONEC12	6
Upper aerodigestive tract	PECAPJ41CLONED2	5.6
Upper aerodigestive tract	PECAPJ49	5.6
Upper aerodigestive tract	SCC15	6.3
Upper aerodigestive tract	SCC25	5.8
Upper aerodigestive tract	SCC4	6
Upper aerodigestive tract	SCC9	5.9
Upper aerodigestive tract	SNU1076	6.1
Upper aerodigestive tract	SNU1214	5.4
Upper aerodigestive tract	SNU46	5.9
Upper aerodigestive tract	SNU899	6.2
Upper aerodigestive tract	YD10B	6.2
Upper aerodigestive tract	YD38	5.8
Upper aerodigestive tract	YD8	6.4
Urinary tract	5637	5.5
Urinary tract	639V	6.1
Urinary tract	647V	6
Urinary tract	BC3C	5.2
Urinary tract	BFTC905	6.4
Urinary tract	CAL29	5.6
Urinary tract	HS172T	5.7
Urinary tract	HT1197	5.3
Urinary tract	HT1376	5.8
Urinary tract	J82	5.1
Urinary tract	JMSU1	5.2
Urinary tract	KMBC2	5.4
Urinary tract	KU1919	5.7
Urinary tract	RT11284	5.3
Urinary tract	RT112	5.3
Urinary tract	RT4	5.4
Urinary tract	SCABER	5.6
Urinary tract	SW1710	5.7
Urinary tract	SW780	5.9
Urinary tract	T24	5
Urinary tract	TCCSUP	6.4
Urinary tract	UMUC1	6.3
Urinary tract	UMUC3	5.6
Urinary tract	VMCUB1	6.2

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	20.5
Adrenal gland	16.7
Appendix	29.5
Bone marrow	23.7
Breast	4.3
Cerebral cortex	10.2
Cervix, uterine	8.1
Colon	7.1
Duodenum	15.2
Endometrium	20
Epididymis	4.1
Esophagus	7.8
Fallopian tube	10.8
Gallbladder	27.7
Heart muscle	5.7
Kidney	5.8
Liver	5.4
Lung	15.1
Lymph node	10.2
Ovary	18.5
Pancreas	3.9
Parathyroid gland	12.5
Placenta	10.2
Prostate	11.3
Rectum	4.6
Salivary gland	3.5
Seminal vesicle	9.2
Skeletal muscle	3.7
Skin	13.3
Small intestine	18
Smooth muscle	8.5
Spleen	20.2
Stomach	8.2
Testis	17.1
Thyroid gland	10.6
Tonsil	4.7
Urinary bladder	12.9

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
27651311	Overexpression	Hepatocellular Carcinoma	Expression levels of JMJD3 in clinical specimens of HCC correlated inversely with patient survival.
26261509	Overexpression	Clear cell Renal Cell Carcinoma	Here, we reported KDM6B has high expression level in ccRCC and is positively correlated with poor ccRCC prognosis.
25652587	Overexpression	Glioma	Querying patient expression profile databases confirmed JMJD3 overexpression in high-grade glioma.
23538751	Overexpression	myelodysplastic syndrome	We then analyzed expression of histone demethylases and observed significant overexpression of the JmjC-domain histone demethylase JMJD3 (KDM6b) in MDS CD34+ cells.
23236496	Overexpression	Breast Carcinoma	Consistently, our analysis of the Oncomine database found that KDM6B expression was significantly increased in invasive breast carcinoma compared with normal breast tissues.
23057811	Overexpression	Renal Cell Carcinoma	This study demonstrated that UTX and JMJD3 were upregulated in cancer tissues, suggesting that they may be involved in the development of primary RCC.
21242977	Overexpression	Hodgkin's Lymphoma	KDM6B is over-expressed in primary HL and induced by the EBV oncogene, latent membrane protein (LMP1) in GC B cells, the presumptive progenitors of HL.
17923864	Overexpression	Prostate Carcinoma	In addition, we found that JMJD3 is upregulated in prostate cancer, and its expression is higher in metastatic prostate cancer.
28197626	Overexpression	Pleural Malignant Mesothelioma	Both Kdm6a and Kdm6b were found to be significantly overexpressed in MPM at the mRNA level.
27983522	Underexpression	Renal Cell Carcinoma	By comparing with adjacent normal tissues, the expression of JMJD3 (10/21 = 47.62%) and UTX (10/21 = 47.62%) were significantly upregulated in bladder cancer tissues and the expression of JMJD3 (15/35 = 42.86%) was significantly downregulated in RCC tissues.
27983522	Overexpression	Bladder Carcinoma	By comparing with adjacent normal tissues, the expression of JMJD3 (10/21 = 47.62%) and UTX (10/21 = 47.62%) were significantly upregulated in bladder cancer tissues and the expression of JMJD3 (15/35 = 42.86%) was significantly downregulated in RCC tissues.
27651311	Underexpression	Hepatocellular Carcinoma	Expression levels of JMJD3 in clinical specimens of hepatocellular carcinoma correlated inversely with patient survival.

Summary
Symbol	KDM6B
Name	lysine demethylase 6B
Aliases	KIAA0346; JMJD3; jumonji domain containing 3; jumonji domain containing 3, histone lysine demethylase; jmjC ......
Location	17p13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.304	4.69e-10	50.7	39.1	10.1	Loss
BRCA	Breast invasive carcinoma	1075	0.42	3.05e-47	60.5	34.2	5.3	Loss
CESC	Cervical and endocervical cancers	292	0.46	1.16e-16	36.3	58.9	4.8	Loss
COAD	Colon adenocarcinoma	449	0.473	2.2e-26	56.1	40.8	3.1	Loss
ESCA	Esophageal carcinoma	183	0.328	5.75e-06	47	41	12	Loss
GBM	Glioblastoma multiforme	147	0.065	0.435	17.7	76.2	6.1	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.285	4.41e-11	24.1	63.8	12.1	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.231	8.57e-08	9.7	85.3	5	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.539	4.36e-23	5.9	36.1	58	Gain
LAML	Acute Myeloid Leukemia	166	0.38	4.56e-07	8.4	91	0.6	Neutral
LGG	Brain Lower Grade Glioma	513	0.145	0.000973	3.1	92.4	4.5	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.493	9.87e-24	60.4	35.7	3.8	Loss
LUAD	Lung adenocarcinoma	512	0.321	9.87e-14	53.5	38.9	7.6	Loss
LUSC	Lung squamous cell carcinoma	498	0.333	2.52e-14	62.9	27.7	9.4	Loss
OV	Ovarian serous cystadenocarcinoma	300	0.521	2.87e-22	73.7	15.3	11	Loss
PAAD	Pancreatic adenocarcinoma	177	0.412	1.24e-08	48.6	46.9	4.5	Loss
PCPG	Pheochromocytoma and Paraganglioma	162	0.374	9.2e-07	39.5	60.5	0	Loss
PRAD	Prostate adenocarcinoma	491	0.229	3e-07	32.8	66.8	0.4	Neutral
READ	Rectum adenocarcinoma	164	0.508	3.75e-12	69.5	28	2.4	Loss
SARC	Sarcoma	255	0.506	5.73e-18	41.2	38.4	20.4	Loss
SKCM	Skin Cutaneous Melanoma	367	0.401	1.21e-15	37.1	53.4	9.5	Loss
STAD	Stomach adenocarcinoma	413	0.348	3.34e-13	41.2	54.7	4.1	Loss
TGCT	Testicular Germ Cell Tumors	150	0.201	0.0135	29.3	45.3	25.3	Neutral
THCA	Thyroid carcinoma	497	0.164	0.000249	1.6	95.2	3.2	Neutral
THYM	Thymoma	119	0.392	1.06e-05	12.6	85.7	1.7	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.533	1.1e-40	25.5	71.5	3	Neutral

Summary
Symbol	KDM6B
Name	lysine demethylase 6B
Aliases	KIAA0346; JMJD3; jumonji domain containing 3; jumonji domain containing 3, histone lysine demethylase; jmjC ......
Location	17p13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.382	1.61e-16	17	408	-0.139	2.04e-10	NS/NA
BRCA	Breast invasive carcinoma	-0.224	2.77e-11	83	785	-0.013	0.0952	NS/NA
CESC	Cervical and endocervical cancers	-0.268	1.85e-06	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.258	3.51e-06	19	297	0.004	8.24e-06	NS/NA
ESCA	Esophageal carcinoma	-0.251	0.000444	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.272	0.0285	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.247	5.92e-09	20	522	0.002	0.0178	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.321	1.36e-09	24	319	-0.27	2.28e-13	Decreased
KIRP	Kidney renal papillary cell carcinoma	-0.304	1.02e-07	23	275	-0.175	5.67e-14	NS/NA
LAML	Acute Myeloid Leukemia	-0.111	0.151	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.382	0	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.425	0	41	373	0.006	9.65e-22	NS/NA
LUAD	Lung adenocarcinoma	-0.206	6.26e-06	21	456	-0.021	0.281	NS/NA
LUSC	Lung squamous cell carcinoma	-0.182	0.000381	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.967	0.000165	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.177	0.0164	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.27	0.000201	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.151	0.000469	35	498	0.003	0.00191	NS/NA
READ	Rectum adenocarcinoma	-0.234	0.0188	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.317	1.79e-07	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.231	4.18e-07	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.207	5.88e-05	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.543	0	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.187	8.73e-06	50	509	0.011	0.0578	NS/NA
THYM	Thymoma	-0.341	0.000135	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.241	1.5e-07	34	431	0.099	1.94e-05	NS/NA

Summary
Symbol	KDM6B
Name	lysine demethylase 6B
Aliases	KIAA0346; JMJD3; jumonji domain containing 3; jumonji domain containing 3, histone lysine demethylase; jmjC ......
Location	17p13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

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Tissue	Level	Level Name
Adrenal gland	3	High
Appendix	2	Medium
Bone marrow	2	Medium
Breast	2	Medium
Bronchus	2	Medium
Caudate	2	Medium
Cerebellum	3	High
Cerebral cortex	2	Medium
Cervix, uterine	1	Low
Colon	3	High
Duodenum	3	High
Endometrium	2	Medium
Epididymis	2	Medium
Esophagus	2	Medium
Fallopian tube	2	Medium
Gallbladder	2	Medium
Heart muscle	1	Low
Hippocampus	1	Low
Kidney	2	Medium
Liver	2	Medium
Lung	2	Medium
Lymph node	1	Low
Nasopharynx	2	Medium
Oral mucosa	2	Medium
Ovary	2	Medium
Pancreas	3	High
Parathyroid gland	2	Medium
Placenta	3	High
Prostate	2	Medium
Rectum	2	Medium
Salivary gland	1	Low
Seminal vesicle	2	Medium
Skeletal muscle	2	Medium
Skin	3	High
Small intestine	2	Medium
Smooth muscle	1	Low
Soft tissue	0	Not detected
Spleen	0	Not detected
Stomach	2	Medium
Testis	2	Medium
Thyroid gland	2	Medium
Tonsil	3	High
Urinary bladder	2	Medium
Vagina	1	Low

Summary
Symbol	KDM6B
Name	lysine demethylase 6B
Aliases	KIAA0346; JMJD3; jumonji domain containing 3; jumonji domain containing 3, histone lysine demethylase; jmjC ......
Location	17p13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

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Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.0761	NS	24476821
BRCA	Breast invasive carcinoma	521	0.00511	Significant	23000897
COAD	Colon adenocarcinoma	149	0.155	NS	22810696
GBM	Glioblastoma multiforme	157	5.02e-07	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	0.00757	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	4.96e-06	Significant	26536169
LGG	Brain Lower Grade Glioma	513	2e-19	Significant	26824661
LUAD	Lung adenocarcinoma	230	0.000692	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	0.143	NS	22960745
OV	Ovarian serous cystadenocarcinoma	287	8.41e-08	Significant	21720365
PRAD	Prostate adenocarcinoma	333	0.0192	Significant	26544944
READ	Rectum adenocarcinoma	67	0.352	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.00361	Significant	26091043
STAD	Stomach adenocarcinoma	277	0.00266	Significant	25079317
THCA	Thyroid carcinoma	391	0.721	NS	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	3.47e-05	Significant	23636398

> Overall survival

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Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	0.868	0.532	NS
BRCA	Breast invasive carcinoma	1079	1.145	0.547	NS
CESC	Cervical and endocervical cancers	291	1.261	0.516	NS
COAD	Colon adenocarcinoma	439	1.34	0.326	NS
ESCA	Esophageal carcinoma	184	1.185	0.587	NS
GBM	Glioblastoma multiforme	158	1.285	0.321	NS
HNSC	Head and Neck squamous cell carcinoma	518	1.164	0.424	NS
KIRC	Kidney renal clear cell carcinoma	531	0.632	0.0312	Longer
KIRP	Kidney renal papillary cell carcinoma	287	0.312	0.0199	Longer
LAML	Acute Myeloid Leukemia	149	0.766	0.353	NS
LGG	Brain Lower Grade Glioma	511	0.468	0.00309	Longer
LIHC	Liver hepatocellular carcinoma	365	0.774	0.282	NS
LUAD	Lung adenocarcinoma	502	0.956	0.835	NS
LUSC	Lung squamous cell carcinoma	494	1.208	0.345	NS
OV	Ovarian serous cystadenocarcinoma	303	1.384	0.123	NS
PAAD	Pancreatic adenocarcinoma	177	0.428	0.00559	Longer
PCPG	Pheochromocytoma and Paraganglioma	179	1.291	0.838	NS
PRAD	Prostate adenocarcinoma	497	3.509	0.112	NS
READ	Rectum adenocarcinoma	159	1.016	0.977	NS
SARC	Sarcoma	259	1.039	0.892	NS
SKCM	Skin Cutaneous Melanoma	459	1.092	0.647	NS
STAD	Stomach adenocarcinoma	388	1.077	0.74	NS
TGCT	Testicular Germ Cell Tumors	134	0.949	0.971	NS
THCA	Thyroid carcinoma	500	502985538.523	0.00683	Shorter
THYM	Thymoma	119	0.285	0.12	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	0.622	0.0949	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	-0.133	0.00722	Lower
BRCA	Breast invasive carcinoma	1071	0.029	0.338	NS
CESC	Cervical and endocervical cancers	167	0.078	0.319	NS
COAD	Colon adenocarcinoma	445	-0.014	0.775	NS
ESCA	Esophageal carcinoma	162	-0.043	0.583	NS
HNSC	Head and Neck squamous cell carcinoma	448	0.053	0.267	NS
KIRC	Kidney renal clear cell carcinoma	531	-0.155	0.000333	Lower
KIRP	Kidney renal papillary cell carcinoma	260	-0.178	0.0039	Lower
LIHC	Liver hepatocellular carcinoma	347	-0.084	0.116	NS
LUAD	Lung adenocarcinoma	507	-0.028	0.525	NS
LUSC	Lung squamous cell carcinoma	497	-0.027	0.543	NS
OV	Ovarian serous cystadenocarcinoma	302	-0.16	0.00544	Lower
PAAD	Pancreatic adenocarcinoma	176	0.005	0.945	NS
READ	Rectum adenocarcinoma	156	-0.052	0.518	NS
SKCM	Skin Cutaneous Melanoma	410	0.025	0.608	NS
STAD	Stomach adenocarcinoma	392	-0.008	0.877	NS
TGCT	Testicular Germ Cell Tumors	81	0.004	0.972	NS
THCA	Thyroid carcinoma	499	-0.018	0.694	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	-0.145	0.00116	Lower

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	-0.126	0.0374	Lower
HNSC	Head and Neck squamous cell carcinoma	498	-0.153	0.00059	Lower
KIRC	Kidney renal clear cell carcinoma	525	-0.226	1.66e-07	Lower
LGG	Brain Lower Grade Glioma	514	-0.006	0.9	NS
LIHC	Liver hepatocellular carcinoma	366	-0.052	0.317	NS
OV	Ovarian serous cystadenocarcinoma	296	0.009	0.873	NS
PAAD	Pancreatic adenocarcinoma	176	-0.132	0.0811	NS
STAD	Stomach adenocarcinoma	406	-0.056	0.257	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	-0.182	2.24e-05	Lower

Summary
Symbol	KDM6B
Name	lysine demethylase 6B
Aliases	KIAA0346; JMJD3; jumonji domain containing 3; jumonji domain containing 3, histone lysine demethylase; jmjC ......
Location	17p13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	KDM6B
Name	lysine demethylase 6B
Aliases	KIAA0346; JMJD3; jumonji domain containing 3; jumonji domain containing 3, histone lysine demethylase; jmjC ......
Location	17p13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for KDM6B.

Summary
Symbol	KDM6B
Name	lysine demethylase 6B
Aliases	KIAA0346; JMJD3; jumonji domain containing 3; jumonji domain containing 3, histone lysine demethylase; jmjC ......
Location	17p13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

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PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
27651311	Hepatocellular Carcinoma	downstream	SLUG	Positive regulation	Mechanistically, JMJD3 modulated H3K27me3 in the SLUG gene promoter, a histone mark associated with active SLUG transcription. SLUG silencing blocked JMJD3-induced EMT, stemness, and metastasis. Furthermore, SLUG expression in hepatocellular carcinoma clinical specimens correlated positively with JMJD3 expression.
26261509	Clear cell Renal Cell Carcinoma	downstream	SLUG	Positive regulation	ChIP assays revealed that KDM6B stimulated SLUG expression by demethylate histone H3K27me3.
25652587	Glioma	downstream	SASP-assoicated genes; SA-β-gal activity	Positive regulation	Overexpressing wild-type JMJD3 (JMJD3wt) activated SASP-associated genes, enhanced SA-β-gal activity, and induced nuclear blebbing.
23538751	myelodysplastic syndrome	downstream	NF-κB	Positive regulation	Furthermore, we demonstrate that JMJD3 has a positive effect on transcription of multiple CHIP-Seq identified genes involved in NF-κB activation
23236496	Breast Carcinoma	upstream	TGF-β	Positive regulation	KDM6B was induced by TGF-β, and the knockdown of KDM6B inhibited EMT induced by TGF-β.
23236496	Breast Carcinoma	downstream	SNAI1	Positive regulation	Chromatin immunoprecipitation (ChIP) assays revealed that KDM6B promoted SNAI1 expression by removing histone H3 lysine trimethylation marks