CR2Cancer

Summary
Symbol	KMT2E
Name	lysine methyltransferase 2E
Aliases	HDCMC04P; MLL5; myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila); NKp44L; histon ......
Location	7q22.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

[ TOP ]

Domain

PF00628 PHD-finger
PF00856 SET domain

Function

Histone methyltransferase that specifically mono- and dimethylates 'Lys-4' of histone H3 (H3K4me1 and H3K4me2). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation. Plays an essential role in retinoic-acid-induced granulopoiesis by acting as a coactivator of RAR-alpha (RARA) in target gene promoters. Also acts as an important cell cycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages. Required to suppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes in quiescent cells. Overexpression inhibits cell cycle progression, while knockdown induces cell cycle arrest at both the G1 and G2/M phases.; FUNCTION: Isoform NKp44L: Cellular ligand for NCR2/NKp44, may play a role as a danger signal in cytotoxicity and NK-cell-mediated innate immunity.

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification write	Histone methylation	H3K4	H3K4me1, H3K4me2	19377461

> Gene Ontology [ TOP ]
Biological Process	GO:0001101 response to acid chemical GO:0002262 myeloid cell homeostasis GO:0002274 myeloid leukocyte activation GO:0002443 leukocyte mediated immunity GO:0002444 myeloid leukocyte mediated immunity GO:0002446 neutrophil mediated immunity GO:0002521 leukocyte differentiation GO:0002573 myeloid leukocyte differentiation GO:0002761 regulation of myeloid leukocyte differentiation GO:0002763 positive regulation of myeloid leukocyte differentiation GO:0006304 DNA modification GO:0006305 DNA alkylation GO:0006306 DNA methylation GO:0006479 protein methylation GO:0007050 cell cycle arrest GO:0008213 protein alkylation GO:0016570 histone modification GO:0016571 histone methylation GO:0018022 peptidyl-lysine methylation GO:0018205 peptidyl-lysine modification GO:0030099 myeloid cell differentiation GO:0030218 erythrocyte differentiation GO:0030522 intracellular receptor signaling pathway GO:0030851 granulocyte differentiation GO:0030852 regulation of granulocyte differentiation GO:0030854 positive regulation of granulocyte differentiation GO:0032259 methylation GO:0032526 response to retinoic acid GO:0034101 erythrocyte homeostasis GO:0034968 histone lysine methylation GO:0036230 granulocyte activation GO:0042119 neutrophil activation GO:0043414 macromolecule methylation GO:0044728 DNA methylation or demethylation GO:0045637 regulation of myeloid cell differentiation GO:0045639 positive regulation of myeloid cell differentiation GO:0045786 negative regulation of cell cycle GO:0048384 retinoic acid receptor signaling pathway GO:0048872 homeostasis of number of cells GO:0051568 histone H3-K4 methylation GO:0071229 cellular response to acid chemical GO:0071300 cellular response to retinoic acid GO:0071396 cellular response to lipid GO:1902105 regulation of leukocyte differentiation GO:1902107 positive regulation of leukocyte differentiation GO:1903706 regulation of hemopoiesis GO:1903708 positive regulation of hemopoiesis
Molecular Function	GO:0003713 transcription coactivator activity GO:0008168 methyltransferase activity GO:0008170 N-methyltransferase activity GO:0008276 protein methyltransferase activity GO:0008757 S-adenosylmethionine-dependent methyltransferase activity GO:0016278 lysine N-methyltransferase activity GO:0016279 protein-lysine N-methyltransferase activity GO:0016741 transferase activity, transferring one-carbon groups GO:0018024 histone-lysine N-methyltransferase activity GO:0042054 histone methyltransferase activity GO:0042800 histone methyltransferase activity (H3-K4 specific)
Cellular Component	GO:0016604 nuclear body GO:0016607 nuclear speck GO:0034708 methyltransferase complex GO:0035097 histone methyltransferase complex GO:0045171 intercellular bridge GO:0070688 MLL5-L complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa00310 Lysine degradation
Reactome	R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-3214841: PKMTs methylate histone lysines

Summary
Symbol	KMT2E
Name	lysine methyltransferase 2E
Aliases	HDCMC04P; MLL5; myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila); NKp44L; histon ......
Location	7q22.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM5756935	c.1993C>T	p.R665C	Substitution - Missense	Large_intestine
COSM4637501	c.3751C>A	p.Q1251K	Substitution - Missense	Large_intestine
COSM1292393	c.4070C>T	p.P1357L	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM119772	c.4771C>G	p.P1591A	Substitution - Missense	Ovary
COSM4955547	c.5470G>A	p.V1824I	Substitution - Missense	Liver
COSM5031123	c.2645C>T	p.S882L	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4570704	c.3084T>A	p.D1028E	Substitution - Missense	Skin
COSM5945100	c.1696C>T	p.Q566*	Substitution - Nonsense	Haematopoietic_and_lymphoid_tissue
COSM3876912	c.4871C>T	p.A1624V	Substitution - Missense	Stomach
COSM4384159	c.4445A>G	p.H1482R	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1447016	c.3499C>T	p.R1167C	Substitution - Missense	Large_intestine
COSM1622170	c.5043A>C	p.P1681P	Substitution - coding silent	Lung
COSM4702523	c.364A>G	p.I122V	Substitution - Missense	Large_intestine
COSM335249	c.2787C>T	p.P929P	Substitution - coding silent	Lung
COSM4702529	c.1732G>T	p.E578*	Substitution - Nonsense	Large_intestine
COSM5014728	c.1220T>A	p.I407N	Substitution - Missense	Kidney
COSM5024262	c.67T>C	p.S23P	Substitution - Missense	Bone
COSM744287	c.4730C>T	p.S1577F	Substitution - Missense	Lung
COSM1755006	c.653C>T	p.S218L	Substitution - Missense	Urinary_tract
COSM3876909	c.4522G>A	p.A1508T	Substitution - Missense	Stomach
COSM3777994	c.3263C>T	p.T1088I	Substitution - Missense	Urinary_tract
COSM1083677	c.2685T>A	p.Y895*	Substitution - Nonsense	Endometrium
COSM3662775	c.169A>G	p.I57V	Substitution - Missense	Liver
COSM1447022	c.5505A>C	p.G1835G	Substitution - coding silent	Large_intestine
COSM1739354	c.2423C>A	p.T808N	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3876908	c.3765A>G	p.S1255S	Substitution - coding silent	Stomach
COSM484582	c.3595T>C	p.C1199R	Substitution - Missense	Kidney
COSM162522	c.4261G>A	p.V1421I	Substitution - Missense	Breast
COSM4955547	c.5470G>A	p.V1824I	Substitution - Missense	Liver
COSM1447012	c.2613delA	p.K873fs*8	Deletion - Frameshift	Prostate
COSM4702535	c.4743G>A	p.V1581V	Substitution - coding silent	Large_intestine
COSM1257804	c.2888G>A	p.R963H	Substitution - Missense	Oesophagus
COSM276082	c.1260A>C	p.E420D	Substitution - Missense	Large_intestine
COSM1447012	c.2613delA	p.K873fs*8	Deletion - Frameshift	Large_intestine
COSM5945102	c.1756C>T	p.Q586*	Substitution - Nonsense	Haematopoietic_and_lymphoid_tissue
COSM4384160	c.4754G>A	p.G1585E	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM276083	c.2621G>A	p.R874Q	Substitution - Missense	Endometrium
COSM5956081	c.2544C>G	p.V848V	Substitution - coding silent	Upper_aerodigestive_tract
COSM5482746	c.3194C>T	p.S1065F	Substitution - Missense	Large_intestine
COSM240700	c.25G>C	p.V9L	Substitution - Missense	Prostate
COSM5632083	c.1729G>A	p.E577K	Substitution - Missense	Oesophagus
COSM3253905	c.280A>G	p.T94A	Substitution - Missense	Large_intestine
COSM3253943	c.2208T>A	p.N736K	Substitution - Missense	Large_intestine
COSM1292394	c.4952C>G	p.S1651C	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM381175	c.3058G>A	p.V1020M	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4853368	c.4762C>G	p.Q1588E	Substitution - Missense	Cervix
COSM1757177	c.4441C>T	p.H1481Y	Substitution - Missense	Urinary_tract
COSM1257804	c.2888G>A	p.R963H	Substitution - Missense	Large_intestine
COSM3631654	c.1764T>C	p.F588F	Substitution - coding silent	Skin
COSM3876907	c.2743C>T	p.R915W	Substitution - Missense	Stomach
COSM3777986	c.1521G>A	p.Q507Q	Substitution - coding silent	Urinary_tract
COSM484586	c.5037A>C	p.P1679P	Substitution - coding silent	Kidney
COSM4384168	c.5504G>A	p.G1835E	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM484586	c.5037A>C	p.P1679P	Substitution - coding silent	Liver
COSM1083687	c.3427G>A	p.D1143N	Substitution - Missense	Endometrium
COSM4835224	c.5233C>G	p.Q1745E	Substitution - Missense	Cervix
COSM4822520	c.5230C>T	p.H1744Y	Substitution - Missense	Cervix
COSM299753	c.3319C>T	p.L1107L	Substitution - coding silent	Large_intestine
COSM3777988	c.1698G>A	p.Q566Q	Substitution - coding silent	Oesophagus
COSM262037	c.2855C>A	p.S952Y	Substitution - Missense	Large_intestine
COSM3777996	c.5158C>G	p.P1720A	Substitution - Missense	Urinary_tract
COSM5503293	c.1434G>A	p.M478I	Substitution - Missense	Biliary_tract
COSM1083688	c.3962T>G	p.L1321R	Substitution - Missense	Endometrium
COSM1447014	c.3125C>A	p.P1042H	Substitution - Missense	Large_intestine
COSM1215212	c.1225C>T	p.R409W	Substitution - Missense	Large_intestine
COSM1173275	c.4406C>G	p.P1469R	Substitution - Missense	Oesophagus
COSM1215214	c.680G>T	p.R227I	Substitution - Missense	Large_intestine
COSM5637565	c.3122C>T	p.T1041M	Substitution - Missense	Oesophagus
COSM1447010	c.1652delA	p.T553fs*7	Deletion - Frameshift	Large_intestine
COSM3254005	c.5319G>A	p.P1773P	Substitution - coding silent	Large_intestine
COSM351482	c.292G>C	p.D98H	Substitution - Missense	Lung
COSM3431049	c.557-2A>C	p.?	Unknown	Large_intestine
COSM3253946	c.2276G>A	p.R759H	Substitution - Missense	Pancreas
COSM1083685	c.3420T>C	p.N1140N	Substitution - coding silent	Endometrium
COSM332118	c.4440T>A	p.P1480P	Substitution - coding silent	Lung
COSM3876914	c.5203T>C	p.S1735P	Substitution - Missense	Stomach
COSM3431053	c.1345G>C	p.D449H	Substitution - Missense	Large_intestine
COSM1312554	c.1636A>G	p.I546V	Substitution - Missense	Urinary_tract
COSM4384157	c.2150T>C	p.V717A	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1447015	c.3462G>T	p.K1154N	Substitution - Missense	Large_intestine
COSM1757176	c.3881A>T	p.H1294L	Substitution - Missense	Urinary_tract
COSM1447012	c.2613delA	p.K873fs*8	Deletion - Frameshift	Large_intestine
COSM4788665	c.32C>T	p.T11I	Substitution - Missense	Liver
COSM5406144	c.3176G>A	p.G1059E	Substitution - Missense	Skin
COSM4914362	c.1781G>A	p.R594K	Substitution - Missense	Liver
COSM1083678	c.2704G>A	p.D902N	Substitution - Missense	Large_intestine
COSM4956444	c.696G>A	p.G232G	Substitution - coding silent	Liver
COSM124461	c.2845G>C	p.E949Q	Substitution - Missense	Upper_aerodigestive_tract
COSM5807213	c.3374C>A	p.S1125Y	Substitution - Missense	Liver
COSM5820264	c.607T>C	p.Y203H	Substitution - Missense	Liver
COSM1447013	c.2736G>A	p.T912T	Substitution - coding silent	Large_intestine
COSM3631656	c.3246C>T	p.S1082S	Substitution - coding silent	Skin
COSM3777995	c.4540A>C	p.T1514P	Substitution - Missense	Urinary_tract
COSM4702536	c.4831C>T	p.P1611S	Substitution - Missense	Large_intestine
COSM3995244	c.785T>G	p.I262S	Substitution - Missense	Kidney
COSM1173274	c.2275C>T	p.R759C	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5944302	c.3412delA	p.N1138fs*4	Deletion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM744291	c.1902A>G	p.E634E	Substitution - coding silent	Lung
COSM3662831	c.612T>A	p.T204T	Substitution - coding silent	Liver
COSM5923782	c.4837C>T	p.Q1613*	Substitution - Nonsense	Skin
COSM4384158	c.3443C>T	p.P1148L	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3777992	c.1716G>A	p.R572R	Substitution - coding silent	Urinary_tract
COSM1662794	c.1783G>A	p.E595K	Substitution - Missense	Kidney
COSM3831522	c.260A>G	p.N87S	Substitution - Missense	Breast
COSM1257804	c.2888G>A	p.R963H	Substitution - Missense	Biliary_tract
COSM5574756	c.2386C>A	p.P796T	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1083687	c.3427G>A	p.D1143N	Substitution - Missense	Stomach
COSM3876896	c.226G>A	p.A76T	Substitution - Missense	Stomach
COSM4553802	c.601G>A	p.E201K	Substitution - Missense	Skin
COSM4549004	c.4626G>A	p.T1542T	Substitution - coding silent	Skin
COSM5466968	c.1507G>T	p.D503Y	Substitution - Missense	Large_intestine
COSM4414589	c.3876G>T	p.P1292P	Substitution - coding silent	Kidney
COSM5512425	c.4004C>T	p.T1335M	Substitution - Missense	Biliary_tract
COSM1622164	c.2775T>C	p.N925N	Substitution - coding silent	Liver
COSM1215211	c.1913G>A	p.S638N	Substitution - Missense	Large_intestine
COSM391382	c.2557delA	p.S854fs*5	Deletion - Frameshift	Lung
COSM4954686	c.4212A>G	p.L1404L	Substitution - coding silent	Liver
COSM262037	c.2855C>A	p.S952Y	Substitution - Missense	Endometrium
COSM325826	c.1607C>T	p.S536L	Substitution - Missense	Lung
COSM3253943	c.2208T>A	p.N736K	Substitution - Missense	Large_intestine
COSM5607498	c.2107G>A	p.E703K	Substitution - Missense	Skin
COSM1257804	c.2888G>A	p.R963H	Substitution - Missense	Large_intestine
COSM1447009	c.1651_1652insA	p.T553fs*4	Insertion - Frameshift	Large_intestine
COSM5419191	c.1136_1137insA	p.Y379fs*1	Insertion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM4879116	c.5255C>T	p.S1752L	Substitution - Missense	Prostate
COSM1447008	c.1214G>A	p.R405Q	Substitution - Missense	Large_intestine
COSM1622168	c.3964_3965insT	p.M1322fs*5	Insertion - Frameshift	Liver
COSM3253990	c.4707T>C	p.Y1569Y	Substitution - coding silent	Large_intestine
COSM5801590	c.4740_4741delTG	p.F1582fs*>277	Deletion - Frameshift	Breast
COSM1757176	c.3881A>T	p.H1294L	Substitution - Missense	Urinary_tract
COSM1083695	c.5525C>T	p.A1842V	Substitution - Missense	Endometrium
COSM162523	c.4264C>T	p.R1422C	Substitution - Missense	Breast
COSM3254005	c.5319G>A	p.P1773P	Substitution - coding silent	Central_nervous_system
COSM3253978	c.4148C>G	p.T1383R	Substitution - Missense	Large_intestine
COSM4587025	c.194A>G	p.N65S	Substitution - Missense	Bone
COSM1662796	c.2202G>T	p.L734F	Substitution - Missense	Kidney
COSM330518	c.2077A>T	p.I693F	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1622169	c.4578A>G	p.Q1526Q	Substitution - coding silent	Liver
COSM1662795	c.1796A>T	p.E599V	Substitution - Missense	Kidney
COSM4384158	c.3443C>T	p.P1148L	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM387806	c.769-2A>T	p.?	Unknown	Lung
COSM4950200	c.4640C>T	p.P1547L	Substitution - Missense	Liver
COSM5358472	c.395T>C	p.M132T	Substitution - Missense	Large_intestine
COSM452105	c.4478G>A	p.R1493Q	Substitution - Missense	Breast
COSM1447012	c.2613delA	p.K873fs*8	Deletion - Frameshift	Large_intestine
COSM744292	c.186G>T	p.A62A	Substitution - coding silent	Lung
COSM4702530	c.3003G>A	p.T1001T	Substitution - coding silent	Large_intestine
COSM4928894	c.2701A>G	p.T901A	Substitution - Missense	Liver
COSM1083667	c.134_135delTA	p.T47fs*18	Deletion - Frameshift	Endometrium
COSM484584	c.4763A>G	p.Q1588R	Substitution - Missense	Kidney
COSM1330199	c.2792A>G	p.Y931C	Substitution - Missense	Ovary
COSM1447013	c.2736G>A	p.T912T	Substitution - coding silent	Stomach
COSM6012839	c.2596+4G>A	p.?	Unknown	Skin
COSM3831528	c.3321G>A	p.L1107L	Substitution - coding silent	Breast
COSM484581	c.1248+1G>A	p.?	Unknown	Kidney
COSM484587	c.5433C>A	p.F1811L	Substitution - Missense	Kidney
COSM1757177	c.4441C>T	p.H1481Y	Substitution - Missense	Urinary_tract
COSM5976167	c.3600C>G	p.A1200A	Substitution - coding silent	Upper_aerodigestive_tract
COSM4384164	c.5162C>T	p.P1721L	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM484586	c.5037A>C	p.P1679P	Substitution - coding silent	Large_intestine
COSM1215212	c.1225C>T	p.R409W	Substitution - Missense	Large_intestine
COSM5406143	c.2384C>T	p.S795L	Substitution - Missense	Skin
COSM1568717	c.3600C>T	p.A1200A	Substitution - coding silent	Large_intestine
COSM3631650	c.1293T>A	p.Y431*	Substitution - Nonsense	Skin
COSM744288	c.4645C>T	p.P1549S	Substitution - Missense	Lung
COSM1286216	c.5276C>A	p.P1759Q	Substitution - Missense	Autonomic_ganglia
COSM5646076	c.2815C>T	p.P939S	Substitution - Missense	Oesophagus
COSM1622167	c.3797A>G	p.Y1266C	Substitution - Missense	Liver
COSM484585	c.5006A>G	p.H1669R	Substitution - Missense	Kidney
COSM4950200	c.4640C>T	p.P1547L	Substitution - Missense	Liver
COSM360341	c.3481G>A	p.E1161K	Substitution - Missense	Lung
COSM4384163	c.5084A>G	p.H1695R	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM162524	c.2375G>A	p.R792K	Substitution - Missense	Breast
COSM3876900	c.497+2T>C	p.?	Unknown	Stomach
COSM1488102	c.1183G>T	p.V395F	Substitution - Missense	Breast
COSM4702525	c.937delA	p.E315fs*2	Deletion - Frameshift	Large_intestine
COSM3631655	c.2855C>T	p.S952F	Substitution - Missense	Skin
COSM1257804	c.2888G>A	p.R963H	Substitution - Missense	Small_intestine
COSM4384165	c.5168C>T	p.P1723L	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1622163	c.1030A>G	p.K344E	Substitution - Missense	Liver
COSM1083676	c.2416G>T	p.E806*	Substitution - Nonsense	Endometrium
COSM3254015	c.5484G>A	p.Q1828Q	Substitution - coding silent	Large_intestine
COSM1622163	c.1030A>G	p.K344E	Substitution - Missense	Liver
COSM1083672	c.1122C>A	p.F374L	Substitution - Missense	Endometrium
COSM484586	c.5037A>C	p.P1679P	Substitution - coding silent	Liver
COSM1622170	c.5043A>C	p.P1681P	Substitution - coding silent	Liver
COSM1137600	c.556+2T>C	p.?	Unknown	Kidney
COSM484586	c.5037A>C	p.P1679P	Substitution - coding silent	Thyroid
COSM3662775	c.169A>G	p.I57V	Substitution - Missense	Liver
COSM5422644	c.3403C>T	p.R1135W	Substitution - Missense	Prostate
COSM3831520	c.128A>C	p.H43P	Substitution - Missense	Breast
COSM3431051	c.1304G>T	p.S435I	Substitution - Missense	Large_intestine
COSM1083684	c.3298C>T	p.R1100*	Substitution - Nonsense	Endometrium
COSM1083680	c.2763A>C	p.E921D	Substitution - Missense	Endometrium
COSM1330198	c.2938G>C	p.G980R	Substitution - Missense	Ovary
COSM4530372	c.1693G>A	p.E565K	Substitution - Missense	Skin
COSM4916668	c.5250T>G	p.F1750L	Substitution - Missense	Liver
COSM1699146	c.4246_4247CC>TT	p.P1416F	Substitution - Missense	Skin
COSM5567398	c.417C>T	p.S139S	Substitution - coding silent	Prostate
COSM4403280	c.3408T>C	p.T1136T	Substitution - coding silent	Skin
COSM124460	c.1922C>T	p.T641I	Substitution - Missense	Upper_aerodigestive_tract
COSM1286215	c.3397T>A	p.F1133I	Substitution - Missense	Autonomic_ganglia
COSM3725381	c.3359C>T	p.T1120I	Substitution - Missense	Lung
COSM5801672	c.130_143del14	p.Y46fs*15	Deletion - Frameshift	Breast
COSM4384153	c.1488A>T	p.K496N	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM484586	c.5037A>C	p.P1679P	Substitution - coding silent	Kidney
COSM4444128	c.2879T>C	p.I960T	Substitution - Missense	Large_intestine
COSM269595	c.4283T>C	p.L1428P	Substitution - Missense	Large_intestine
COSM5062073	c.5159C>T	p.P1720L	Substitution - Missense	Stomach
COSM1622166	c.3336T>G	p.T1112T	Substitution - coding silent	Liver
COSM1083686	c.3426C>T	p.I1142I	Substitution - coding silent	Stomach
COSM3876913	c.4881C>A	p.P1627P	Substitution - coding silent	Stomach
COSM276083	c.2621G>A	p.R874Q	Substitution - Missense	Large_intestine
COSM3631646	c.660T>C	p.V220V	Substitution - coding silent	Skin
COSM1083673	c.1418G>A	p.R473H	Substitution - Missense	Endometrium
COSM3631648	c.794C>T	p.S265L	Substitution - Missense	Skin
COSM3995248	c.3257A>T	p.D1086V	Substitution - Missense	Kidney
COSM3876911	c.4835C>T	p.S1612F	Substitution - Missense	Stomach
COSM4384166	c.5279C>T	p.P1760L	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3777990	c.1705G>A	p.E569K	Substitution - Missense	Urinary_tract
COSM1643195	c.4998G>A	p.S1666S	Substitution - coding silent	Stomach
COSM4768761	c.3581A>G	p.N1194S	Substitution - Missense	Biliary_tract
COSM4838379	c.5086C>G	p.P1696A	Substitution - Missense	Cervix
COSM385508	c.1843G>A	p.E615K	Substitution - Missense	Lung
COSM484586	c.5037A>C	p.P1679P	Substitution - coding silent	Pleura
COSM3631660	c.5155C>T	p.P1719S	Substitution - Missense	Skin
COSM3876910	c.4810G>C	p.V1604L	Substitution - Missense	Stomach
COSM1755006	c.653C>T	p.S218L	Substitution - Missense	Urinary_tract
COSM484586	c.5037A>C	p.P1679P	Substitution - coding silent	Lung
COSM1643195	c.4998G>A	p.S1666S	Substitution - coding silent	Stomach
COSM1447009	c.1651_1652insA	p.T553fs*4	Insertion - Frameshift	Large_intestine
COSM1257805	c.2620C>T	p.R874*	Substitution - Nonsense	Oesophagus
COSM1699145	c.2755G>C	p.D919H	Substitution - Missense	Skin
COSM1447011	c.2398_2399insA	p.R802fs*8	Insertion - Frameshift	Large_intestine
COSM1447020	c.4412C>A	p.S1471*	Substitution - Nonsense	Liver
COSM1083678	c.2704G>A	p.D902N	Substitution - Missense	Endometrium
COSM1083690	c.4365G>A	p.T1455T	Substitution - coding silent	Pancreas
COSM3253968	c.3375C>T	p.S1125S	Substitution - coding silent	Large_intestine
COSM245714	c.1339G>T	p.D447Y	Substitution - Missense	Prostate
COSM3729948	c.4056delA	p.M1354fs*1	Deletion - Frameshift	Stomach
COSM4977032	c.186G>A	p.A62A	Substitution - coding silent	Oesophagus
COSM4993689	c.3477_3478insGGGAGCCT	p.L1160fs*4	Insertion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM1083689	c.4162G>A	p.E1388K	Substitution - Missense	Endometrium
COSM4933727	c.2518C>T	p.Q840*	Substitution - Nonsense	Liver
COSM6007388	c.2036C>A	p.P679Q	Substitution - Missense	Prostate
COSM4384164	c.5162C>T	p.P1721L	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4702533	c.4475A>C	p.Q1492P	Substitution - Missense	Large_intestine
COSM162522	c.4261G>A	p.V1421I	Substitution - Missense	Large_intestine
COSM5632451	c.3494G>C	p.R1165T	Substitution - Missense	Oesophagus
COSM5715318	c.1132C>A	p.P378T	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5480500	c.1123T>G	p.F375V	Substitution - Missense	Large_intestine
COSM1083694	c.5508G>T	p.Q1836H	Substitution - Missense	Biliary_tract
COSM3631659	c.4537G>A	p.A1513T	Substitution - Missense	Skin
COSM5756933	c.1475G>A	p.G492E	Substitution - Missense	Large_intestine
COSM1257804	c.2888G>A	p.R963H	Substitution - Missense	Large_intestine
COSM452107	c.5527C>A	p.Q1843K	Substitution - Missense	Breast
COSM3662831	c.612T>A	p.T204T	Substitution - coding silent	Liver
COSM3876894	c.34G>A	p.A12T	Substitution - Missense	Stomach
COSM3995246	c.897G>C	p.E299D	Substitution - Missense	Kidney
COSM3941928	c.2199C>T	p.H733H	Substitution - coding silent	Oesophagus
COSM1635033	c.1772T>G	p.L591R	Substitution - Missense	Liver
COSM4609277	c.794C>A	p.S265*	Substitution - Nonsense	Adrenal_gland
COSM5788767	c.1774G>A	p.E592K	Substitution - Missense	Breast
COSM5738089	c.695G>A	p.G232E	Substitution - Missense	Small_intestine
COSM3431055	c.2597-1G>T	p.?	Unknown	Large_intestine
COSM5653009	c.876C>T	p.Y292Y	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM1083694	c.5508G>T	p.Q1836H	Substitution - Missense	Endometrium
COSM5823016	c.611C>G	p.T204S	Substitution - Missense	Liver
COSM392036	c.571_572insT	p.A191fs*3	Insertion - Frameshift	Lung
COSM4384161	c.4975G>A	p.V1659I	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4499522	c.5444C>T	p.P1815L	Substitution - Missense	Skin
COSM5785293	c.3844+6T>A	p.?	Unknown	Breast
COSM1083679	c.2726C>T	p.S909F	Substitution - Missense	Endometrium
COSM1083686	c.3426C>T	p.I1142I	Substitution - coding silent	Endometrium
COSM3876892	c.17C>A	p.P6Q	Substitution - Missense	Stomach
COSM380663	c.2445C>A	p.C815*	Substitution - Nonsense	Lung
COSM3876904	c.1964C>G	p.S655C	Substitution - Missense	Stomach
COSM5461481	c.2272C>G	p.L758V	Substitution - Missense	Large_intestine
COSM3922424	c.284C>T	p.P95L	Substitution - Missense	Breast
COSM3876915	c.5419A>G	p.T1807A	Substitution - Missense	Stomach
COSM4655394	c.5042C>A	p.P1681Q	Substitution - Missense	Large_intestine
COSM1488103	c.4214C>T	p.S1405L	Substitution - Missense	Breast
COSM4161698	c.5326C>A	p.Q1776K	Substitution - Missense	Thyroid
COSM276083	c.2621G>A	p.R874Q	Substitution - Missense	Large_intestine
COSM1083675	c.1846T>C	p.C616R	Substitution - Missense	Endometrium
COSM4941264	c.1852G>C	p.D618H	Substitution - Missense	Liver
COSM1083673	c.1418G>A	p.R473H	Substitution - Missense	Large_intestine
COSM5026798	c.3323T>C	p.M1108T	Substitution - Missense	Breast
COSM262038	c.3827G>A	p.R1276Q	Substitution - Missense	Large_intestine
COSM1447018	c.3832G>C	p.D1278H	Substitution - Missense	Large_intestine
COSM4788665	c.32C>T	p.T11I	Substitution - Missense	Liver
COSM4826346	c.4942C>T	p.Q1648*	Substitution - Nonsense	Cervix
COSM1083683	c.3081C>T	p.L1027L	Substitution - coding silent	Endometrium
COSM4421732	c.4730C>A	p.S1577Y	Substitution - Missense	Pleura
COSM5423947	c.1604_1605delTA	p.V537fs*3	Deletion - Frameshift	Prostate
COSM3631644	c.619C>T	p.Q207*	Substitution - Nonsense	Skin
COSM1083681	c.2853T>A	p.I951I	Substitution - coding silent	Endometrium
COSM1488103	c.4214C>T	p.S1405L	Substitution - Missense	Upper_aerodigestive_tract
COSM1580169	c.632C>A	p.T211K	Substitution - Missense	Central_nervous_system
COSM4628570	c.2407A>G	p.R803G	Substitution - Missense	Large_intestine
COSM1083668	c.674A>C	p.D225A	Substitution - Missense	Endometrium
COSM4384162	c.5065C>T	p.H1689Y	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4625891	c.3210C>T	p.S1070S	Substitution - coding silent	Large_intestine
COSM3876906	c.2482A>C	p.N828H	Substitution - Missense	Stomach
COSM1083691	c.4452G>A	p.Q1484Q	Substitution - coding silent	Endometrium
COSM5521352	c.5284C>T	p.P1762S	Substitution - Missense	Biliary_tract
COSM5638738	c.1506A>G	p.K502K	Substitution - coding silent	Oesophagus
COSM5406145	c.4400C>T	p.P1467L	Substitution - Missense	Skin
COSM71657	c.3683C>G	p.S1228C	Substitution - Missense	Ovary
COSM221740	c.2979A>C	p.Q993H	Substitution - Missense	Skin
COSM3941929	c.4369C>T	p.H1457Y	Substitution - Missense	Oesophagus
COSM1643194	c.1476delA	p.D495fs*26	Deletion - Frameshift	Stomach
COSM5631581	c.2563C>T	p.P855S	Substitution - Missense	Oesophagus
COSM3831526	c.1609G>A	p.V537I	Substitution - Missense	Breast
COSM1083692	c.4768C>G	p.L1590V	Substitution - Missense	Endometrium
COSM6012840	c.4025A>G	p.D1342G	Substitution - Missense	Skin
COSM1292394	c.4952C>G	p.S1651C	Substitution - Missense	Upper_aerodigestive_tract
COSM405217	c.1651delG	p.E551fs*9	Deletion - Frameshift	Lung
COSM1083671	c.1011A>C	p.Q337H	Substitution - Missense	Endometrium
COSM744290	c.3082G>C	p.D1028H	Substitution - Missense	Lung
COSM1447019	c.4260C>T	p.H1420H	Substitution - coding silent	Large_intestine
COSM1330200	c.2716A>C	p.M906L	Substitution - Missense	Ovary
COSM4433705	c.1144G>T	p.V382L	Substitution - Missense	Oesophagus
COSM3631658	c.4249C>T	p.P1417S	Substitution - Missense	Skin
COSM1622166	c.3336T>G	p.T1112T	Substitution - coding silent	Liver
COSM4777680	c.4599_4600insG	p.F1534fs*2	Insertion - Frameshift	Prostate
COSM4153727	c.3705C>T	p.C1235C	Substitution - coding silent	Ovary
COSM3631652	c.1328C>T	p.T443I	Substitution - Missense	Skin
COSM3253973	c.3904C>G	p.H1302D	Substitution - Missense	Upper_aerodigestive_tract
COSM4435165	c.3969A>G	p.E1323E	Substitution - coding silent	Oesophagus
COSM5504819	c.731C>T	p.A244V	Substitution - Missense	Biliary_tract
COSM484586	c.5037A>C	p.P1679P	Substitution - coding silent	Thyroid
COSM4954686	c.4212A>G	p.L1404L	Substitution - coding silent	Liver
COSM1215213	c.656G>T	p.R219I	Substitution - Missense	Large_intestine
COSM282821	c.958G>A	p.D320N	Substitution - Missense	Large_intestine
COSM3253905	c.280A>G	p.T94A	Substitution - Missense	Large_intestine
COSM4385626	c.2518_2519insA	p.E841fs*11	Insertion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM4384149	c.1248G>T	p.E416D	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4956444	c.696G>A	p.G232G	Substitution - coding silent	Liver
COSM3777988	c.1698G>A	p.Q566Q	Substitution - coding silent	Urinary_tract
COSM4384155	c.1490A>T	p.D497V	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM139726	c.1334C>T	p.A445V	Substitution - Missense	Skin
COSM1622169	c.4578A>G	p.Q1526Q	Substitution - coding silent	Liver
COSM1622170	c.5043A>C	p.P1681P	Substitution - coding silent	Thyroid
COSM1447015	c.3462G>T	p.K1154N	Substitution - Missense	Large_intestine
COSM3253964	c.3179G>A	p.R1060Q	Substitution - Missense	Large_intestine
COSM1187403	c.5413A>G	p.T1805A	Substitution - Missense	Lung
COSM1083674	c.1795G>T	p.E599*	Substitution - Nonsense	Endometrium
COSM1622165	c.2942_2943insTTTT	p.R983fs*2	Insertion - Frameshift	Liver
COSM1447017	c.3755+2T>C	p.?	Unknown	Large_intestine
COSM1173274	c.2275C>T	p.R759C	Substitution - Missense	Oesophagus
COSM5763723	c.4884T>C	p.P1628P	Substitution - coding silent	Large_intestine
COSM3876898	c.457C>T	p.H153Y	Substitution - Missense	Stomach
COSM1083678	c.2704G>A	p.D902N	Substitution - Missense	Large_intestine
COSM1083684	c.3298C>T	p.R1100*	Substitution - Nonsense	Breast
COSM1757178	c.4486C>A	p.Q1496K	Substitution - Missense	Urinary_tract
COSM1312555	c.4099C>G	p.Q1367E	Substitution - Missense	Urinary_tract
COSM4702534	c.4655_4657delCTT	p.S1555delS	Deletion - In frame	Large_intestine
COSM3631661	c.5244A>G	p.P1748P	Substitution - coding silent	Skin
COSM5062072	c.2514C>A	p.P838P	Substitution - coding silent	Stomach
COSM276083	c.2621G>A	p.R874Q	Substitution - Missense	Endometrium
COSM1292392	c.2627T>G	p.F876C	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1286216	c.5276C>A	p.P1759Q	Substitution - Missense	Autonomic_ganglia
COSM1666277	c.3860G>A	p.C1287Y	Substitution - Missense	Eye
COSM3831524	c.653C>G	p.S218*	Substitution - Nonsense	Breast
COSM362993	c.1225C>G	p.R409G	Substitution - Missense	Lung
COSM3253984	c.4569C>A	p.P1523P	Substitution - coding silent	Large_intestine
COSM4702532	c.4353A>G	p.P1451P	Substitution - coding silent	Large_intestine
COSM5510244	c.1994G>A	p.R665H	Substitution - Missense	Biliary_tract
COSM3922424	c.284C>T	p.P95L	Substitution - Missense	Skin
COSM3631657	c.3254G>A	p.R1085K	Substitution - Missense	Skin
COSM5442352	c.42G>A	p.T14T	Substitution - coding silent	Oesophagus
COSM3253958	c.2713C>T	p.P905S	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM78096	c.4411T>A	p.S1471T	Substitution - Missense	Ovary
COSM4702531	c.3445C>G	p.Q1149E	Substitution - Missense	Large_intestine
COSM1083693	c.4932G>A	p.P1644P	Substitution - coding silent	Endometrium
COSM1622164	c.2775T>C	p.N925N	Substitution - coding silent	Liver
COSM5674582	c.379C>G	p.H127D	Substitution - Missense	Soft_tissue
COSM282822	c.3494G>T	p.R1165I	Substitution - Missense	Large_intestine
COSM1083670	c.970A>C	p.N324H	Substitution - Missense	Endometrium
COSM5782954	c.139A>C	p.T47P	Substitution - Missense	Breast
COSM4384158	c.3443C>T	p.P1148L	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1622166	c.3336T>G	p.T1112T	Substitution - coding silent	Liver
COSM1083669	c.921A>G	p.L307L	Substitution - coding silent	Endometrium
COSM1083682	c.2980G>T	p.E994*	Substitution - Nonsense	Endometrium
COSM3876905	c.1988A>G	p.Q663R	Substitution - Missense	Stomach
COSM4384167	c.5423C>T	p.A1808V	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM240701	c.4193_4194delAG	p.E1398fs*9	Deletion - Frameshift	Prostate
COSM85598	c.1661delC	p.P554fs*6	Deletion - Frameshift	Pancreas
COSM4384158	c.3443C>T	p.P1148L	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5997655	c.2735C>T	p.T912M	Substitution - Missense	Prostate
COSM4384151	c.1369G>A	p.V457M	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3254005	c.5319G>A	p.P1773P	Substitution - coding silent	Large_intestine
COSM744289	c.4508C>T	p.A1503V	Substitution - Missense	Lung
COSM262036	c.1014G>T	p.K338N	Substitution - Missense	Large_intestine
COSM1622170	c.5043A>C	p.P1681P	Substitution - coding silent	Thyroid
COSM5031123	c.2645C>T	p.S882L	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1447011	c.2398_2399insA	p.R802fs*8	Insertion - Frameshift	Pancreas
COSM3876902	c.1655A>C	p.K552T	Substitution - Missense	Stomach
COSM1257804	c.2888G>A	p.R963H	Substitution - Missense	Stomach
COSM5997655	c.2735C>T	p.T912M	Substitution - Missense	Prostate
COSM3831529	c.5172C>T	p.S1724S	Substitution - coding silent	Breast
COSM484583	c.4194G>T	p.E1398D	Substitution - Missense	Kidney
COSM3374443	c.557-1G>T	p.?	Unknown	Thyroid
COSM404889	c.847delC	p.R283fs*21	Deletion - Frameshift	Lung
COSM484586	c.5037A>C	p.P1679P	Substitution - coding silent	Thyroid
COSM4389077	c.3523A>G	p.K1175E	Substitution - Missense	Pancreas
COSM4495074	c.4459C>G	p.Q1487E	Substitution - Missense	Skin
COSM381175	c.3058G>A	p.V1020M	Substitution - Missense	Lung
COSM3411443	c.17C>T	p.P6L	Substitution - Missense	Central_nervous_system
COSM3831518	c.68C>G	p.S23*	Substitution - Nonsense	Breast
COSM1643194	c.1476delA	p.D495fs*26	Deletion - Frameshift	Large_intestine
COSM221741	c.4042T>A	p.C1348S	Substitution - Missense	Skin
COSM1083690	c.4365G>A	p.T1455T	Substitution - coding silent	Endometrium
COSM3253948	c.2310A>G	p.Q770Q	Substitution - coding silent	Pancreas
COSM5987133	c.3509_3510delGG	p.R1170fs*5	Deletion - Frameshift	Salivary_gland
COSM1488103	c.4214C>T	p.S1405L	Substitution - Missense	Upper_aerodigestive_tract
COSM1635034	c.2059A>C	p.T687P	Substitution - Missense	Liver
COSM1757178	c.4486C>A	p.Q1496K	Substitution - Missense	Urinary_tract

> Text Mining based Variations

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PMID	Variation	Cancer	Evidence
23259788	Mutation	Gastric Carcinoma; Colorectal Carcinoma	We also analyzed MLL3 expression in GC and CRC tissues using immunohistochemistry. We found MLL, MLL2, MLL3 and MLL5 frameshift mutations in two (one GC and one CRC), three (one GC and two CRC), 17 (14 GC and three CRC) and six (four GC and two CRC) cancers, respectively.
21670448	Mutation	Leukemia	MLL5 includes a SET domain and a single PHD finger, but lacks A-T hooks and methyltransferase homology domains that are found in MLL. The leukemia cell line RCV-ACV-A carries a heterozygous missense mutation within the PHD domain; however, no mutations within the MLL5 coding region were detected in primary leukemias.

Summary
Symbol	KMT2E
Name	lysine methyltransferase 2E
Aliases	HDCMC04P; MLL5; myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila); NKp44L; histon ......
Location	7q22.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

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Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
Q8IZD2	837	S	Phosphoserine	-	No	None detected
Q8IZD2	845	S	Phosphoserine	-	No	None detected
Q8IZD2	1070	S	Phosphoserine	-	No	None detected
Q8IZD2	1273	S	Phosphoserine	-	No	None detected
Q8IZD2	1359	S	Phosphoserine	-	No	None detected

Summary
Symbol	KMT2E
Name	lysine methyltransferase 2E
Aliases	HDCMC04P; MLL5; myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila); NKp44L; histon ......
Location	7q22.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

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Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	6.648	5.918	-0.575	0.0043	NS
BRCA	Breast invasive carcinoma	112	1100	7.04	6.584	-0.456	6.74e-11	NS
CESC	Cervical and endocervical cancers	3	306	6.614	5.902	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	6.951	6.237	-0.649	1.47e-12	Under
ESCA	Esophageal carcinoma	11	185	7.128	7.121	-0.056	0.835	NS
GBM	Glioblastoma multiforme	5	166	6.384	6.3	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	6.105	5.804	-0.278	0.0522	NS
KIRC	Kidney renal clear cell carcinoma	72	534	6.517	6.746	0.214	0.00115	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	6.263	6.138	-0.21	0.173	NS
LAML	Acute Myeloid Leukemia	0	173	NA	7.985	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	6.717	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	4.591	4.567	-0.068	0.628	NS
LUAD	Lung adenocarcinoma	59	517	6.681	6.404	-0.257	0.000631	NS
LUSC	Lung squamous cell carcinoma	51	501	6.738	6.231	-0.525	4.42e-11	NS
OV	Ovarian serous cystadenocarcinoma	0	307	NA	6.709	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	6.38	6.285	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	5.442	5.926	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	6.709	6.34	-0.459	2.88e-05	NS
READ	Rectum adenocarcinoma	10	167	6.778	6.342	-0.394	0.0672	NS
SARC	Sarcoma	2	263	5.266	5.932	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	6.504	6.579	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	6.919	7.074	0.054	0.642	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	5.597	NA	NA	NA
THCA	Thyroid carcinoma	59	509	6.664	6.496	-0.11	0.175	NS
THYM	Thymoma	2	120	6.71	6.028	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	6.677	6.169	-0.608	1.59e-06	Under

> Cancer Cell Line Encyclopedia (CCLE)

[ TOP ]

Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	10.9
Autonomic ganglia	CHP212	9.4
Autonomic ganglia	IMR32	9.6
Autonomic ganglia	KELLY	9.2
Autonomic ganglia	KPNRTBM1	10.4
Autonomic ganglia	KPNSI9S	9.6
Autonomic ganglia	KPNYN	10.2
Autonomic ganglia	MHHNB11	11
Autonomic ganglia	NB1	9.6
Autonomic ganglia	NH6	10.4
Autonomic ganglia	SHSY5Y	10.8
Autonomic ganglia	SIMA	10.2
Autonomic ganglia	SKNAS	8.9
Autonomic ganglia	SKNBE2	10
Autonomic ganglia	SKNDZ	9.4
Autonomic ganglia	SKNFI	8.9
Autonomic ganglia	SKNSH	9.1
Biliary tract	HUCCT1	8.3
Biliary tract	HUH28	8.3
Biliary tract	SNU1079	9.2
Biliary tract	SNU1196	8.8
Biliary tract	SNU245	9.4
Biliary tract	SNU308	8.8
Biliary tract	SNU478	9.2
Bone	143B	8.4
Bone	A673	9.4
Bone	CADOES1	9.7
Bone	CAL78	9.6
Bone	G292CLONEA141B1	8.8
Bone	HOS	9.2
Bone	HS706T	8.9
Bone	HS737T	9
Bone	HS819T	9
Bone	HS821T	9
Bone	HS822T	9.3
Bone	HS863T	9.4
Bone	HS870T	9.2
Bone	HS888T	9.5
Bone	MG63	8.3
Bone	MHHES1	10.2
Bone	OUMS27	10.1
Bone	RDES	9.2
Bone	SJSA1	9.1
Bone	SKES1	9.7
Bone	SKNMC	9.3
Bone	SW1353	9.7
Bone	T173	8.8
Bone	TC71	9.1
Bone	U2OS	9.9
Breast	AU565	8.9
Breast	BT20	8.3
Breast	BT474	9.9
Breast	BT483	9.8
Breast	BT549	8.6
Breast	CAL120	9.3
Breast	CAL148	11.1
Breast	CAL51	10.1
Breast	CAL851	8.4
Breast	CAMA1	9.8
Breast	DU4475	9.8
Breast	EFM192A	9.1
Breast	EFM19	9
Breast	EVSAT	9.8
Breast	HCC1143	7.6
Breast	HCC1187	9.9
Breast	HCC1395	10
Breast	HCC1419	8.8
Breast	HCC1428	9.9
Breast	HCC1500	9.4
Breast	HCC1569	9.4
Breast	HCC1599	9.2
Breast	HCC1806	9.8
Breast	HCC1937	8.4
Breast	HCC1954	9.2
Breast	HCC202	9.8
Breast	HCC2157	9.4
Breast	HCC2218	8.7
Breast	HCC38	9.9
Breast	HCC70	9.5
Breast	HDQP1	9.8
Breast	HMC18	8.7
Breast	HS274T	9.2
Breast	HS281T	9.3
Breast	HS343T	8.8
Breast	HS578T	9.4
Breast	HS606T	9.3
Breast	HS739T	9.3
Breast	HS742T	8.6
Breast	JIMT1	7.4
Breast	KPL1	10
Breast	MCF7	9.7
Breast	MDAMB134VI	7.7
Breast	MDAMB157	9.6
Breast	MDAMB175VII	8.9
Breast	MDAMB231	9.1
Breast	MDAMB361	8.1
Breast	MDAMB415	9.6
Breast	MDAMB436	9
Breast	MDAMB453	8.1
Breast	MDAMB468	9
Breast	SKBR3	9.6
Breast	T47D	8.6
Breast	UACC812	8.5
Breast	UACC893	9.3
Breast	YMB1	9.1
Breast	ZR751	8.8
Breast	ZR7530	9.7
Central nervous system	1321N1	9.6
Central nervous system	42MGBA	9.6
Central nervous system	8MGBA	9.1
Central nervous system	A172	8.8
Central nervous system	AM38	8.2
Central nervous system	BECKER	9.9
Central nervous system	CAS1	9.7
Central nervous system	CCFSTTG1	9.9
Central nervous system	D283MED	9.2
Central nervous system	D341MED	10.4
Central nervous system	DAOY	10.1
Central nervous system	DBTRG05MG	9.1
Central nervous system	DKMG	10.3
Central nervous system	GAMG	9.1
Central nervous system	GB1	8.8
Central nervous system	GI1	9.4
Central nervous system	GMS10	8.2
Central nervous system	GOS3	9.5
Central nervous system	H4	8.8
Central nervous system	HS683	9.7
Central nervous system	KALS1	8.8
Central nervous system	KG1C	9.1
Central nervous system	KNS42	9.1
Central nervous system	KNS60	9.3
Central nervous system	KNS81	9.3
Central nervous system	KS1	9.5
Central nervous system	LN18	9.9
Central nervous system	LN229	9.5
Central nervous system	M059K	9.1
Central nervous system	MOGGCCM	9.7
Central nervous system	MOGGUVW	9.2
Central nervous system	NMCG1	9.3
Central nervous system	ONS76	10.4
Central nervous system	SF126	8.7
Central nervous system	SF295	9.5
Central nervous system	SNB19	9.7
Central nervous system	SNU1105	9.7
Central nervous system	SNU201	9.1
Central nervous system	SNU466	9.7
Central nervous system	SNU489	9
Central nervous system	SNU626	10.1
Central nervous system	SNU738	9.4
Central nervous system	SW1088	9.8
Central nervous system	SW1783	9.4
Central nervous system	T98G	9.2
Central nervous system	TM31	9.2
Central nervous system	U118MG	9.4
Central nervous system	U138MG	10.4
Central nervous system	U251MG	10.2
Central nervous system	U87MG	8.8
Central nervous system	YH13	9.7
Central nervous system	YKG1	10.1
Endometrium	AN3CA	9.7
Endometrium	COLO684	10.1
Endometrium	EFE184	8.2
Endometrium	EN	8.9
Endometrium	ESS1	9.1
Endometrium	HEC108	9.8
Endometrium	HEC151	8.9
Endometrium	HEC1A	9.1
Endometrium	HEC1B	10.1
Endometrium	HEC251	9.5
Endometrium	HEC265	8.6
Endometrium	HEC50B	8.5
Endometrium	HEC59	9.8
Endometrium	HEC6	9.9
Endometrium	ISHIKAWAHERAKLIO02ER	9.3
Endometrium	JHUEM1	8.7
Endometrium	JHUEM2	9.8
Endometrium	JHUEM3	9.8
Endometrium	KLE	8
Endometrium	MFE280	8.5
Endometrium	MFE296	9.3
Endometrium	MFE319	8.7
Endometrium	RL952	9.5
Endometrium	SNGM	8.7
Endometrium	SNU1077	9.3
Endometrium	SNU685	9.3
Endometrium	TEN	9.1
Haematopoietic and lymphoid	697	9.9
Haematopoietic and lymphoid	A3KAW	9.3
Haematopoietic and lymphoid	A4FUK	10.2
Haematopoietic and lymphoid	ALLSIL	10
Haematopoietic and lymphoid	AML193	9.9
Haematopoietic and lymphoid	AMO1	9.7
Haematopoietic and lymphoid	BCP1	9.7
Haematopoietic and lymphoid	BDCM	9.6
Haematopoietic and lymphoid	BL41	10.5
Haematopoietic and lymphoid	BL70	10.3
Haematopoietic and lymphoid	BV173	10.2
Haematopoietic and lymphoid	CA46	9.7
Haematopoietic and lymphoid	CI1	9.5
Haematopoietic and lymphoid	CMK115	10.1
Haematopoietic and lymphoid	CMK86	9.9
Haematopoietic and lymphoid	CMK	9.5
Haematopoietic and lymphoid	CMLT1	10.1
Haematopoietic and lymphoid	COLO775	9
Haematopoietic and lymphoid	DAUDI	9.3
Haematopoietic and lymphoid	DB	9.9
Haematopoietic and lymphoid	DEL	10.7
Haematopoietic and lymphoid	DND41	10.1
Haematopoietic and lymphoid	DOHH2	10.4
Haematopoietic and lymphoid	EB1	9.4
Haematopoietic and lymphoid	EB2	10
Haematopoietic and lymphoid	EHEB	10
Haematopoietic and lymphoid	EJM	10.4
Haematopoietic and lymphoid	EM2	9.4
Haematopoietic and lymphoid	EOL1	9.7
Haematopoietic and lymphoid	F36P	9.5
Haematopoietic and lymphoid	GA10	9.3
Haematopoietic and lymphoid	GDM1	9.5
Haematopoietic and lymphoid	GRANTA519	9.9
Haematopoietic and lymphoid	HDLM2	9.7
Haematopoietic and lymphoid	HDMYZ	10.3
Haematopoietic and lymphoid	HEL9217	8.6
Haematopoietic and lymphoid	HEL	8.8
Haematopoietic and lymphoid	HH	10
Haematopoietic and lymphoid	HL60	10.5
Haematopoietic and lymphoid	HPBALL	10.6
Haematopoietic and lymphoid	HS604T	9
Haematopoietic and lymphoid	HS611T	9.6
Haematopoietic and lymphoid	HS616T	9
Haematopoietic and lymphoid	HS751T	9.4
Haematopoietic and lymphoid	HT	9.5
Haematopoietic and lymphoid	HTK	8.3
Haematopoietic and lymphoid	HUNS1	9.4
Haematopoietic and lymphoid	HUT102	10.2
Haematopoietic and lymphoid	HUT78	9.5
Haematopoietic and lymphoid	JEKO1	10.8
Haematopoietic and lymphoid	JK1	10.3
Haematopoietic and lymphoid	JM1	9.7
Haematopoietic and lymphoid	JURKAT	10.3
Haematopoietic and lymphoid	JURLMK1	9.9
Haematopoietic and lymphoid	JVM2	10
Haematopoietic and lymphoid	JVM3	9.8
Haematopoietic and lymphoid	K562	9.3
Haematopoietic and lymphoid	KARPAS299	9.5
Haematopoietic and lymphoid	KARPAS422	9.7
Haematopoietic and lymphoid	KARPAS620	10.4
Haematopoietic and lymphoid	KASUMI1	10.2
Haematopoietic and lymphoid	KASUMI2	10.8
Haematopoietic and lymphoid	KASUMI6	9.9
Haematopoietic and lymphoid	KCL22	9.2
Haematopoietic and lymphoid	KE37	10.1
Haematopoietic and lymphoid	KE97	9.1
Haematopoietic and lymphoid	KG1	9
Haematopoietic and lymphoid	KHM1B	10.1
Haematopoietic and lymphoid	KIJK	9.6
Haematopoietic and lymphoid	KMH2	9.2
Haematopoietic and lymphoid	KMM1	10.2
Haematopoietic and lymphoid	KMS11	10.1
Haematopoietic and lymphoid	KMS12BM	10.8
Haematopoietic and lymphoid	KMS18	9.8
Haematopoietic and lymphoid	KMS20	9.6
Haematopoietic and lymphoid	KMS21BM	9.7
Haematopoietic and lymphoid	KMS26	9.8
Haematopoietic and lymphoid	KMS27	9.1
Haematopoietic and lymphoid	KMS28BM	10.4
Haematopoietic and lymphoid	KMS34	10.8
Haematopoietic and lymphoid	KO52	9.1
Haematopoietic and lymphoid	KOPN8	9.2
Haematopoietic and lymphoid	KU812	9.3
Haematopoietic and lymphoid	KYO1	8.9
Haematopoietic and lymphoid	L1236	10.2
Haematopoietic and lymphoid	L363	10.8
Haematopoietic and lymphoid	L428	10.4
Haematopoietic and lymphoid	L540	9.9
Haematopoietic and lymphoid	LAMA84	8.7
Haematopoietic and lymphoid	LOUCY	10
Haematopoietic and lymphoid	LP1	10.8
Haematopoietic and lymphoid	M07E	9.8
Haematopoietic and lymphoid	MC116	10
Haematopoietic and lymphoid	ME1	8.7
Haematopoietic and lymphoid	MEC1	10
Haematopoietic and lymphoid	MEC2	9.7
Haematopoietic and lymphoid	MEG01	9.1
Haematopoietic and lymphoid	MHHCALL2	11.1
Haematopoietic and lymphoid	MHHCALL3	10.9
Haematopoietic and lymphoid	MHHCALL4	10.9
Haematopoietic and lymphoid	MINO	10.1
Haematopoietic and lymphoid	MJ	9.2
Haematopoietic and lymphoid	MM1S	10
Haematopoietic and lymphoid	MOLM13	9.2
Haematopoietic and lymphoid	MOLM16	9.9
Haematopoietic and lymphoid	MOLM6	9.8
Haematopoietic and lymphoid	MOLP2	9.5
Haematopoietic and lymphoid	MOLP8	10.3
Haematopoietic and lymphoid	MOLT13	10.6
Haematopoietic and lymphoid	MOLT16	10.6
Haematopoietic and lymphoid	MOLT4	10.2
Haematopoietic and lymphoid	MONOMAC1	9.6
Haematopoietic and lymphoid	MONOMAC6	9.7
Haematopoietic and lymphoid	MOTN1	10.4
Haematopoietic and lymphoid	MUTZ5	10.8
Haematopoietic and lymphoid	MV411	9.9
Haematopoietic and lymphoid	NALM19	10.5
Haematopoietic and lymphoid	NALM1	11.1
Haematopoietic and lymphoid	NALM6	10.9
Haematopoietic and lymphoid	NAMALWA	10.4
Haematopoietic and lymphoid	NB4	10.1
Haematopoietic and lymphoid	NCIH929	9.6
Haematopoietic and lymphoid	NCO2	9.3
Haematopoietic and lymphoid	NOMO1	8.5
Haematopoietic and lymphoid	NUDHL1	9.8
Haematopoietic and lymphoid	NUDUL1	10
Haematopoietic and lymphoid	OCIAML2	9.4
Haematopoietic and lymphoid	OCIAML3	10.3
Haematopoietic and lymphoid	OCIAML5	9.6
Haematopoietic and lymphoid	OCILY10	9.4
Haematopoietic and lymphoid	OCILY19	10.9
Haematopoietic and lymphoid	OCILY3	9.6
Haematopoietic and lymphoid	OCIM1	9.5
Haematopoietic and lymphoid	OPM2	10.9
Haematopoietic and lymphoid	P12ICHIKAWA	10.2
Haematopoietic and lymphoid	P31FUJ	10.1
Haematopoietic and lymphoid	P3HR1	9.4
Haematopoietic and lymphoid	PCM6	9.9
Haematopoietic and lymphoid	PEER	10.5
Haematopoietic and lymphoid	PF382	10.5
Haematopoietic and lymphoid	PFEIFFER	9.8
Haematopoietic and lymphoid	PL21	10.2
Haematopoietic and lymphoid	RAJI	9.4
Haematopoietic and lymphoid	RCHACV	10.5
Haematopoietic and lymphoid	REC1	9.8
Haematopoietic and lymphoid	REH	10.3
Haematopoietic and lymphoid	RI1	10.1
Haematopoietic and lymphoid	RL	9.8
Haematopoietic and lymphoid	RPMI8226	10.3
Haematopoietic and lymphoid	RPMI8402	9.9
Haematopoietic and lymphoid	RS411	10.9
Haematopoietic and lymphoid	SEM	10.7
Haematopoietic and lymphoid	SET2	8.9
Haematopoietic and lymphoid	SIGM5	9.6
Haematopoietic and lymphoid	SKM1	9.7
Haematopoietic and lymphoid	SKMM2	10.2
Haematopoietic and lymphoid	SR786	9.9
Haematopoietic and lymphoid	ST486	9.8
Haematopoietic and lymphoid	SUDHL10	10
Haematopoietic and lymphoid	SUDHL1	8.9
Haematopoietic and lymphoid	SUDHL4	10.1
Haematopoietic and lymphoid	SUDHL5	9.8
Haematopoietic and lymphoid	SUDHL6	10.3
Haematopoietic and lymphoid	SUDHL8	10.4
Haematopoietic and lymphoid	SUPB15	10.2
Haematopoietic and lymphoid	SUPHD1	10
Haematopoietic and lymphoid	SUPM2	9.8
Haematopoietic and lymphoid	SUPT11	9.8
Haematopoietic and lymphoid	SUPT1	10.2
Haematopoietic and lymphoid	TALL1	10.7
Haematopoietic and lymphoid	TF1	8.5
Haematopoietic and lymphoid	THP1	9.3
Haematopoietic and lymphoid	TO175T	9.1
Haematopoietic and lymphoid	TOLEDO	10
Haematopoietic and lymphoid	U266B1	10.2
Haematopoietic and lymphoid	U937	9.6
Haematopoietic and lymphoid	UT7	10.2
Haematopoietic and lymphoid	WSUDLCL2	9.8
Kidney	769P	9.1
Kidney	786O	9.1
Kidney	A498	8.9
Kidney	A704	10
Kidney	ACHN	10
Kidney	BFTC909	10.1
Kidney	CAKI1	9.2
Kidney	CAKI2	8.4
Kidney	CAL54	9.8
Kidney	KMRC1	9.1
Kidney	KMRC20	10.4
Kidney	KMRC2	9.1
Kidney	KMRC3	9.5
Kidney	OSRC2	9.7
Kidney	RCC10RGB	9.7
Kidney	SNU1272	9.4
Kidney	SNU349	8.9
Kidney	TUHR10TKB	9.8
Kidney	TUHR14TKB	9.9
Kidney	TUHR4TKB	9.4
Kidney	VMRCRCW	9.6
Kidney	VMRCRCZ	10.2
Large intestine	C2BBE1	8.9
Large intestine	CCK81	9.4
Large intestine	CL11	9.8
Large intestine	CL14	9.6
Large intestine	CL34	9.4
Large intestine	CL40	8.5
Large intestine	COLO205	9.2
Large intestine	COLO320	9
Large intestine	COLO678	10.2
Large intestine	CW2	9.4
Large intestine	DLD1	9.1
Large intestine	GP2D	9.3
Large intestine	HCC56	9.9
Large intestine	HCT116	8.8
Large intestine	HCT15	9.1
Large intestine	HS675T	9.4
Large intestine	HS698T	9.2
Large intestine	HT115	9.7
Large intestine	HT29	9.4
Large intestine	HT55	9.5
Large intestine	KM12	9.4
Large intestine	LOVO	9.3
Large intestine	LS1034	8.7
Large intestine	LS123	8.7
Large intestine	LS180	9.4
Large intestine	LS411N	9.8
Large intestine	LS513	9.7
Large intestine	MDST8	9.6
Large intestine	NCIH508	10.3
Large intestine	NCIH716	9.9
Large intestine	NCIH747	9.6
Large intestine	OUMS23	8.9
Large intestine	RCM1	9.8
Large intestine	RKO	9.9
Large intestine	SKCO1	10.7
Large intestine	SNU1040	9.8
Large intestine	SNU1197	9.9
Large intestine	SNU175	10.1
Large intestine	SNU283	9.2
Large intestine	SNU407	9.5
Large intestine	SNU503	8.5
Large intestine	SNU61	9.8
Large intestine	SNU81	10.2
Large intestine	SNUC1	10.1
Large intestine	SNUC2A	9.6
Large intestine	SNUC4	9.6
Large intestine	SNUC5	9.4
Large intestine	SW1116	9.6
Large intestine	SW1417	9.6
Large intestine	SW1463	9.2
Large intestine	SW403	9.5
Large intestine	SW480	8.9
Large intestine	SW48	9.6
Large intestine	SW620	9.3
Large intestine	SW837	9.9
Large intestine	SW948	10.4
Large intestine	T84	10.3
Liver	ALEXANDERCELLS	9.4
Liver	C3A	8.9
Liver	HEP3B217	9
Liver	HEPG2	8.7
Liver	HLE	8.5
Liver	HLF	9.2
Liver	HUH1	9.1
Liver	HUH6	9.3
Liver	HUH7	9.1
Liver	JHH1	8.8
Liver	JHH2	9.9
Liver	JHH4	10
Liver	JHH5	9.2
Liver	JHH6	9.7
Liver	JHH7	9.1
Liver	LI7	9.8
Liver	PLCPRF5	9.2
Liver	SKHEP1	10
Liver	SNU182	7.9
Liver	SNU387	9.3
Liver	SNU398	9.4
Liver	SNU423	9.4
Liver	SNU449	9.9
Liver	SNU475	9.2
Liver	SNU761	9.6
Liver	SNU878	8.7
Liver	SNU886	9.6
Lung	A549	8.7
Lung	ABC1	9
Lung	BEN	9.5
Lung	CAL12T	7.6
Lung	CALU1	9.2
Lung	CALU3	8.1
Lung	CALU6	9
Lung	CHAGOK1	9.8
Lung	COLO668	9.1
Lung	COLO699	9.2
Lung	CORL105	9.3
Lung	CORL23	8.1
Lung	CORL24	10.7
Lung	CORL279	9.7
Lung	CORL311	10
Lung	CORL47	9.7
Lung	CORL51	10.2
Lung	CORL88	9.4
Lung	CORL95	9.7
Lung	CPCN	9.7
Lung	DMS114	9.6
Lung	DMS153	9.8
Lung	DMS273	9.5
Lung	DMS454	10
Lung	DMS53	9.6
Lung	DMS79	10.8
Lung	DV90	9.1
Lung	EBC1	9.9
Lung	EPLC272H	9.3
Lung	HARA	9.1
Lung	HCC1171	10
Lung	HCC1195	9.2
Lung	HCC15	9.3
Lung	HCC2279	8.1
Lung	HCC2935	10.6
Lung	HCC33	10.3
Lung	HCC366	9.6
Lung	HCC4006	9
Lung	HCC44	8.6
Lung	HCC78	9.4
Lung	HCC827	9.2
Lung	HCC95	10.3
Lung	HLC1	9.7
Lung	HLFA	9.4
Lung	HS229T	9.1
Lung	HS618T	9.4
Lung	IALM	9
Lung	KNS62	8.8
Lung	LC1F	9.3
Lung	LC1SQSF	10.4
Lung	LCLC103H	9.2
Lung	LCLC97TM1	9.9
Lung	LK2	9.2
Lung	LOUNH91	10
Lung	LU65	8.9
Lung	LU99	7.1
Lung	LUDLU1	9.8
Lung	LXF289	9.5
Lung	MORCPR	8.6
Lung	NCIH1048	10
Lung	NCIH1092	10.9
Lung	NCIH1105	10.6
Lung	NCIH1155	9.3
Lung	NCIH1184	10.9
Lung	NCIH1299	9
Lung	NCIH1339	8.3
Lung	NCIH1341	10.1
Lung	NCIH1355	8.5
Lung	NCIH1373	9.7
Lung	NCIH1385	10.8
Lung	NCIH1395	8.6
Lung	NCIH1435	9.5
Lung	NCIH1436	10
Lung	NCIH1437	8.6
Lung	NCIH146	9.1
Lung	NCIH1563	8
Lung	NCIH1568	8.6
Lung	NCIH1573	9.4
Lung	NCIH1581	9.7
Lung	NCIH1618	9.8
Lung	NCIH1623	9.9
Lung	NCIH1648	9.4
Lung	NCIH1650	8.7
Lung	NCIH1651	9.7
Lung	NCIH1666	9.2
Lung	NCIH1693	9.4
Lung	NCIH1694	10.7
Lung	NCIH1703	9.6
Lung	NCIH1734	9.4
Lung	NCIH1755	9.6
Lung	NCIH1781	9.8
Lung	NCIH1792	8.1
Lung	NCIH1793	9.4
Lung	NCIH1836	9.8
Lung	NCIH1838	9.1
Lung	NCIH1869	9.2
Lung	NCIH1876	10.1
Lung	NCIH1915	9
Lung	NCIH1930	9.6
Lung	NCIH1944	8.7
Lung	NCIH1963	10.5
Lung	NCIH196	9.8
Lung	NCIH1975	9.7
Lung	NCIH2009	9.1
Lung	NCIH2023	8.8
Lung	NCIH2029	10
Lung	NCIH2030	8.8
Lung	NCIH2066	9.9
Lung	NCIH2081	10.7
Lung	NCIH2085	9.6
Lung	NCIH2087	9.1
Lung	NCIH209	9.6
Lung	NCIH2106	8.2
Lung	NCIH2110	9.6
Lung	NCIH211	8.5
Lung	NCIH2122	7.9
Lung	NCIH2126	9.6
Lung	NCIH2141	9.9
Lung	NCIH2170	9.3
Lung	NCIH2171	9.9
Lung	NCIH2172	8.8
Lung	NCIH2196	9.5
Lung	NCIH2227	10.2
Lung	NCIH2228	8.1
Lung	NCIH226	8.9
Lung	NCIH2286	9.3
Lung	NCIH2291	9.7
Lung	NCIH2342	9.5
Lung	NCIH2347	8.8
Lung	NCIH23	8.8
Lung	NCIH2405	9.6
Lung	NCIH2444	9.8
Lung	NCIH292	8.2
Lung	NCIH322	7.8
Lung	NCIH3255	10.1
Lung	NCIH358	9
Lung	NCIH441	10.1
Lung	NCIH446	9.2
Lung	NCIH460	9.2
Lung	NCIH510	8.7
Lung	NCIH520	8.3
Lung	NCIH522	10.2
Lung	NCIH524	9.3
Lung	NCIH526	9.9
Lung	NCIH596	8.8
Lung	NCIH647	9
Lung	NCIH650	10.5
Lung	NCIH661	9.4
Lung	NCIH69	10.1
Lung	NCIH727	9.3
Lung	NCIH810	10.2
Lung	NCIH82	10
Lung	NCIH838	8.9
Lung	NCIH841	10.1
Lung	NCIH854	9.7
Lung	NCIH889	9.7
Lung	PC14	9.4
Lung	RERFLCAD1	9.9
Lung	RERFLCAD2	8.2
Lung	RERFLCAI	9.1
Lung	RERFLCKJ	9.4
Lung	RERFLCMS	9.8
Lung	RERFLCSQ1	10.1
Lung	SBC5	10
Lung	SCLC21H	10.3
Lung	SHP77	8.7
Lung	SKLU1	9.7
Lung	SKMES1	9
Lung	SQ1	8.4
Lung	SW1271	8.7
Lung	SW1573	10
Lung	SW900	9.2
Lung	VMRCLCD	9.6
Lung	VMRCLCP	9.6
Oesophagus	COLO680N	9.1
Oesophagus	ECGI10	8.6
Oesophagus	KYSE140	9.5
Oesophagus	KYSE150	8.9
Oesophagus	KYSE180	9.5
Oesophagus	KYSE270	8.3
Oesophagus	KYSE30	9.2
Oesophagus	KYSE410	10.6
Oesophagus	KYSE450	9
Oesophagus	KYSE510	8.9
Oesophagus	KYSE520	9
Oesophagus	KYSE70	9
Oesophagus	OE19	9.1
Oesophagus	OE33	11
Oesophagus	TE10	9.4
Oesophagus	TE11	9
Oesophagus	TE14	10
Oesophagus	TE15	8.7
Oesophagus	TE1	9
Oesophagus	TE4	8.7
Oesophagus	TE5	10.9
Oesophagus	TE6	8.4
Oesophagus	TE8	9.4
Oesophagus	TE9	9.5
Oesophagus	TT	9.4
Ovary	59M	7.5
Ovary	A2780	9.1
Ovary	CAOV3	9
Ovary	CAOV4	9.8
Ovary	COLO704	10.4
Ovary	COV318	10.2
Ovary	COV362	9.6
Ovary	COV434	10.2
Ovary	COV504	9.3
Ovary	COV644	9.6
Ovary	EFO21	9
Ovary	EFO27	9.1
Ovary	ES2	8.5
Ovary	FUOV1	9.4
Ovary	HEYA8	7.5
Ovary	HS571T	8.9
Ovary	IGROV1	9.6
Ovary	JHOC5	9.1
Ovary	JHOM1	9
Ovary	JHOM2B	10.2
Ovary	JHOS2	8.3
Ovary	JHOS4	8.9
Ovary	KURAMOCHI	10.5
Ovary	MCAS	8.8
Ovary	NIHOVCAR3	8.7
Ovary	OAW28	8.4
Ovary	OAW42	8.6
Ovary	OC314	9.3
Ovary	OC316	9.4
Ovary	ONCODG1	9.1
Ovary	OV56	9.1
Ovary	OV7	9.1
Ovary	OV90	10.3
Ovary	OVCAR4	10.6
Ovary	OVCAR8	8.3
Ovary	OVISE	8.5
Ovary	OVK18	8.7
Ovary	OVKATE	9.8
Ovary	OVMANA	9.9
Ovary	OVSAHO	9.8
Ovary	OVTOKO	8.6
Ovary	RMGI	6.6
Ovary	RMUGS	7.2
Ovary	SKOV3	7.9
Ovary	SNU119	9.3
Ovary	SNU840	8.3
Ovary	SNU8	9.2
Ovary	TOV112D	8.7
Ovary	TOV21G	9.2
Ovary	TYKNU	9.9
Pancreas	ASPC1	9.7
Pancreas	BXPC3	9
Pancreas	CAPAN1	8.9
Pancreas	CAPAN2	9.3
Pancreas	CFPAC1	9.6
Pancreas	DANG	9.6
Pancreas	HPAC	10.2
Pancreas	HPAFII	9.5
Pancreas	HS766T	8.9
Pancreas	HUPT3	9.2
Pancreas	HUPT4	9.3
Pancreas	KCIMOH1	9.6
Pancreas	KLM1	8.3
Pancreas	KP2	9.6
Pancreas	KP3	8.9
Pancreas	KP4	9.6
Pancreas	L33	8.6
Pancreas	MIAPACA2	9.5
Pancreas	PANC0203	9.3
Pancreas	PANC0213	9.1
Pancreas	PANC0327	9.2
Pancreas	PANC0403	9
Pancreas	PANC0504	9.2
Pancreas	PANC0813	8.9
Pancreas	PANC1005	9.5
Pancreas	PANC1	8.9
Pancreas	PATU8902	8.4
Pancreas	PATU8988S	9.2
Pancreas	PATU8988T	8.2
Pancreas	PK1	9
Pancreas	PK45H	9.3
Pancreas	PK59	9.2
Pancreas	PL45	9.8
Pancreas	PSN1	8.2
Pancreas	QGP1	10.3
Pancreas	SNU213	9.2
Pancreas	SNU324	9.8
Pancreas	SNU410	9.6
Pancreas	SU8686	9.4
Pancreas	SUIT2	9.6
Pancreas	SW1990	9.1
Pancreas	T3M4	8.9
Pancreas	TCCPAN2	9.5
Pancreas	YAPC	9.3
Pleura	ACCMESO1	8.7
Pleura	DM3	8.8
Pleura	ISTMES1	9.5
Pleura	ISTMES2	8.8
Pleura	JL1	9.5
Pleura	MPP89	8.3
Pleura	MSTO211H	9.1
Pleura	NCIH2052	8.1
Pleura	NCIH2452	9.8
Pleura	NCIH28	9.6
Prostate	22RV1	9.9
Prostate	DU145	8.7
Prostate	LNCAPCLONEFGC	9.7
Prostate	MDAPCA2B	9.4
Prostate	NCIH660	9.8
Prostate	PC3	8.4
Prostate	VCAP	10.2
Salivary gland	A253	10.2
Salivary gland	YD15	9.2
Skin	A101D	9.7
Skin	A2058	9
Skin	A375	8.5
Skin	C32	10.4
Skin	CHL1	9
Skin	CJM	9.5
Skin	COLO679	9.7
Skin	COLO741	9.5
Skin	COLO783	9.5
Skin	COLO792	9.7
Skin	COLO800	9.7
Skin	COLO818	9.8
Skin	COLO829	9.9
Skin	COLO849	9.7
Skin	G361	9.7
Skin	GRM	8.6
Skin	HMCB	9.3
Skin	HS294T	9.6
Skin	HS600T	9
Skin	HS688AT	9.1
Skin	HS695T	9.2
Skin	HS839T	9.1
Skin	HS852T	9.9
Skin	HS895T	9
Skin	HS934T	9.1
Skin	HS936T	8.7
Skin	HS939T	9.7
Skin	HS940T	9.1
Skin	HS944T	7.9
Skin	HT144	9.2
Skin	IGR1	9.5
Skin	IGR37	8.6
Skin	IGR39	9.3
Skin	IPC298	9.8
Skin	K029AX	8.9
Skin	LOXIMVI	9.1
Skin	MALME3M	10
Skin	MDAMB435S	8.8
Skin	MELHO	9.5
Skin	MELJUSO	8.6
Skin	MEWO	9.4
Skin	RPMI7951	9.4
Skin	RVH421	10
Skin	SH4	9.9
Skin	SKMEL1	9.4
Skin	SKMEL24	9.8
Skin	SKMEL28	8.9
Skin	SKMEL2	8.8
Skin	SKMEL30	9.2
Skin	SKMEL31	10
Skin	SKMEL3	9.2
Skin	SKMEL5	8.9
Skin	UACC257	8.5
Skin	UACC62	9.2
Skin	WM115	9.7
Skin	WM1799	9.6
Skin	WM2664	10.3
Skin	WM793	10
Skin	WM88	9.4
Skin	WM983B	9.1
Small intestine	HUTU80	8.9
Soft tissue	A204	9.7
Soft tissue	G401	8.9
Soft tissue	G402	9.3
Soft tissue	GCT	8.8
Soft tissue	HS729	9.1
Soft tissue	HT1080	8.5
Soft tissue	KYM1	9.5
Soft tissue	MESSA	7.9
Soft tissue	RD	10
Soft tissue	RH30	8.7
Soft tissue	RH41	9.7
Soft tissue	RKN	8.9
Soft tissue	S117	9.4
Soft tissue	SJRH30	9.2
Soft tissue	SKLMS1	9.8
Soft tissue	SKUT1	9.5
Soft tissue	TE125T	8.8
Soft tissue	TE159T	9.2
Soft tissue	TE441T	8.5
Soft tissue	TE617T	9.1
Stomach	2313287	9.8
Stomach	AGS	9.2
Stomach	AZ521	8.7
Stomach	ECC10	10.2
Stomach	ECC12	10
Stomach	FU97	9.3
Stomach	GCIY	8.6
Stomach	GSS	9
Stomach	GSU	9.9
Stomach	HGC27	9
Stomach	HS746T	10.4
Stomach	HUG1N	10
Stomach	IM95	9.9
Stomach	KATOIII	9.2
Stomach	KE39	9.7
Stomach	LMSU	9.3
Stomach	MKN1	9.3
Stomach	MKN45	9.4
Stomach	MKN74	9.7
Stomach	MKN7	8.1
Stomach	NCCSTCK140	8.2
Stomach	NCIN87	8.4
Stomach	NUGC2	8.4
Stomach	NUGC3	8.5
Stomach	NUGC4	9.9
Stomach	OCUM1	9
Stomach	RERFGC1B	9.8
Stomach	SH10TC	8.5
Stomach	SNU16	9.7
Stomach	SNU1	9.7
Stomach	SNU216	10.2
Stomach	SNU520	10.6
Stomach	SNU5	9.8
Stomach	SNU601	8.7
Stomach	SNU620	9.6
Stomach	SNU668	9.9
Stomach	SNU719	9.3
Stomach	TGBC11TKB	9.8
Thyroid	8305C	9.6
Thyroid	8505C	8.5
Thyroid	BCPAP	8.6
Thyroid	BHT101	9.5
Thyroid	CAL62	9.5
Thyroid	CGTHW1	9.1
Thyroid	FTC133	9.6
Thyroid	FTC238	9.3
Thyroid	ML1	9.8
Thyroid	SW579	8.8
Thyroid	TT2609C02	9.5
Thyroid	TT	9.5
Upper aerodigestive tract	BHY	9.4
Upper aerodigestive tract	BICR16	9.5
Upper aerodigestive tract	BICR18	9.8
Upper aerodigestive tract	BICR22	9.6
Upper aerodigestive tract	BICR31	8.7
Upper aerodigestive tract	BICR56	9.6
Upper aerodigestive tract	BICR6	9.3
Upper aerodigestive tract	CAL27	9.1
Upper aerodigestive tract	CAL33	8.9
Upper aerodigestive tract	DETROIT562	9.5
Upper aerodigestive tract	FADU	9.2
Upper aerodigestive tract	HS840T	9
Upper aerodigestive tract	HSC2	8.5
Upper aerodigestive tract	HSC3	8.2
Upper aerodigestive tract	HSC4	10
Upper aerodigestive tract	PECAPJ15	10.4
Upper aerodigestive tract	PECAPJ34CLONEC12	9.4
Upper aerodigestive tract	PECAPJ41CLONED2	8.8
Upper aerodigestive tract	PECAPJ49	8.9
Upper aerodigestive tract	SCC15	9.3
Upper aerodigestive tract	SCC25	8.5
Upper aerodigestive tract	SCC4	8.4
Upper aerodigestive tract	SCC9	8.7
Upper aerodigestive tract	SNU1076	8.9
Upper aerodigestive tract	SNU1214	9.2
Upper aerodigestive tract	SNU46	8
Upper aerodigestive tract	SNU899	9.6
Upper aerodigestive tract	YD10B	9.8
Upper aerodigestive tract	YD38	9.1
Upper aerodigestive tract	YD8	8.8
Urinary tract	5637	8.5
Urinary tract	639V	9
Urinary tract	647V	8.3
Urinary tract	BC3C	8.9
Urinary tract	BFTC905	9.1
Urinary tract	CAL29	10.4
Urinary tract	HS172T	9.3
Urinary tract	HT1197	8.2
Urinary tract	HT1376	8.8
Urinary tract	J82	8.1
Urinary tract	JMSU1	8.7
Urinary tract	KMBC2	9.2
Urinary tract	KU1919	8.4
Urinary tract	RT11284	9.4
Urinary tract	RT112	8.9
Urinary tract	RT4	9.3
Urinary tract	SCABER	9.3
Urinary tract	SW1710	10.3
Urinary tract	SW780	9.2
Urinary tract	T24	8.7
Urinary tract	TCCSUP	5.7
Urinary tract	UMUC1	8.7
Urinary tract	UMUC3	9.9
Urinary tract	VMCUB1	10.1

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	24.1
Adrenal gland	18.9
Appendix	36.7
Bone marrow	43.8
Breast	25.6
Cerebral cortex	41.6
Cervix, uterine	40.9
Colon	26.5
Duodenum	20.2
Endometrium	52.2
Epididymis	24.9
Esophagus	23.3
Fallopian tube	38.1
Gallbladder	35.9
Heart muscle	12.8
Kidney	19.2
Liver	7.9
Lung	39.4
Lymph node	34.3
Ovary	51.8
Pancreas	4.3
Parathyroid gland	40.6
Placenta	35.8
Prostate	35
Rectum	29.5
Salivary gland	9.5
Seminal vesicle	30.9
Skeletal muscle	5
Skin	31.5
Small intestine	22
Smooth muscle	39.1
Spleen	42.2
Stomach	22.6
Testis	32.1
Thyroid gland	42.4
Tonsil	29.5
Urinary bladder	30.5

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
26678539	Underexpression	Breast Carcinoma	In the present study, we used quantitative PCR to investigate the expression profile of all five MLL genes [MLL (ALL-1), MLL2, MLL3, MLL4 and MLL5] in 7 breast cancer cell lines, 8 breast tumors and adjacent non-tumor tissues and in 12 normal tissues. We observed a diminished expression of all five genes in the breast cancer cell lines when compared to normal breast tissue.

Summary
Symbol	KMT2E
Name	lysine methyltransferase 2E
Aliases	HDCMC04P; MLL5; myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila); NKp44L; histon ......
Location	7q22.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.283	7.44e-09	9.9	54.7	35.4	Gain
BRCA	Breast invasive carcinoma	1075	0.181	2.45e-09	14.3	59.3	26.3	Neutral
CESC	Cervical and endocervical cancers	292	0.3	1.74e-07	14.4	70.2	15.4	Neutral
COAD	Colon adenocarcinoma	449	0.272	4.68e-09	1.6	49.7	48.8	Gain
ESCA	Esophageal carcinoma	183	0.611	4.27e-20	16.4	30.6	53	Gain
GBM	Glioblastoma multiforme	147	0.352	1.2e-05	0	17.7	82.3	Gain
HNSC	Head and Neck squamous cell carcinoma	514	0.399	4.81e-21	9.1	61.1	29.8	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.164	0.000155	0.2	66.9	33	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.263	5.89e-06	1.4	38.9	59.7	Gain
LAML	Acute Myeloid Leukemia	166	0.559	5.22e-15	9.6	90.4	0	Neutral
LGG	Brain Lower Grade Glioma	513	0.214	1.04e-06	0.6	66.5	32.9	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.134	0.0106	8	60.2	31.9	Neutral
LUAD	Lung adenocarcinoma	512	0.377	9.89e-19	11.3	45.9	42.8	Gain
LUSC	Lung squamous cell carcinoma	498	0.473	3.92e-29	10.8	41	48.2	Gain
OV	Ovarian serous cystadenocarcinoma	300	0.508	4.45e-21	16.7	40	43.3	Gain
PAAD	Pancreatic adenocarcinoma	177	0.212	0.00458	5.1	69.5	25.4	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.37	1.28e-06	5.6	82.1	12.3	Neutral
PRAD	Prostate adenocarcinoma	491	0.187	3.11e-05	2.2	78.2	19.6	Neutral
READ	Rectum adenocarcinoma	164	0.343	6.75e-06	2.4	45.7	51.8	Gain
SARC	Sarcoma	255	0.345	1.49e-08	15.3	55.7	29	Neutral
SKCM	Skin Cutaneous Melanoma	367	0.307	1.89e-09	7.1	38.7	54.2	Gain
STAD	Stomach adenocarcinoma	413	0.527	6.83e-31	12.6	45.8	41.6	Gain
TGCT	Testicular Germ Cell Tumors	150	-0.045	0.581	2.7	26	71.3	Gain
THCA	Thyroid carcinoma	497	-0.05	0.261	0.2	95.8	4	Neutral
THYM	Thymoma	119	0.118	0.201	1.7	84.9	13.4	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.29	7.87e-12	10.2	74.7	15.1	Neutral

Summary
Symbol	KMT2E
Name	lysine methyltransferase 2E
Aliases	HDCMC04P; MLL5; myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila); NKp44L; histon ......
Location	7q22.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.24	5.86e-07	17	408	0.009	2.81e-09	NS/NA
BRCA	Breast invasive carcinoma	-0.252	6.21e-14	83	785	0.036	1.86e-12	NS/NA
CESC	Cervical and endocervical cancers	-0.203	0.000334	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.347	2.86e-10	19	297	0.024	1.22e-17	NS/NA
ESCA	Esophageal carcinoma	-0.436	3.23e-10	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.216	0.0836	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.423	0	20	522	0.002	1.65e-08	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.181	0.00075	24	319	-0.198	1.37e-13	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.442	0	23	275	0.002	0.0745	NS/NA
LAML	Acute Myeloid Leukemia	-0.187	0.0149	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.222	2.61e-07	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.16	0.00108	41	373	0.002	2.7e-06	NS/NA
LUAD	Lung adenocarcinoma	-0.106	0.0212	21	456	0.071	1.03e-28	NS/NA
LUSC	Lung squamous cell carcinoma	-0.176	0.000619	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.517	0.162	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.217	0.00327	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.229	0.00164	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.331	5.63e-15	35	498	0.003	5.92e-06	NS/NA
READ	Rectum adenocarcinoma	-0.234	0.0188	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.221	0.000321	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.33	2.45e-13	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.375	9.85e-14	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.256	0.0013	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.066	0.12	50	509	0.02	0.0348	NS/NA
THYM	Thymoma	-0.143	0.115	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.159	0.000596	34	431	-0.01	0.00964	NS/NA

Summary
Symbol	KMT2E
Name	lysine methyltransferase 2E
Aliases	HDCMC04P; MLL5; myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila); NKp44L; histon ......
Location	7q22.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	0	Not detected
Appendix	0	Not detected
Bone marrow	2	Medium
Breast	0	Not detected
Bronchus	0	Not detected
Caudate	0	Not detected
Cerebellum	0	Not detected
Cerebral cortex	0	Not detected
Cervix, uterine	0	Not detected
Colon	0	Not detected
Duodenum	0	Not detected
Endometrium	0	Not detected
Epididymis	0	Not detected
Esophagus	0	Not detected
Fallopian tube	0	Not detected
Gallbladder	0	Not detected
Heart muscle	0	Not detected
Hippocampus	0	Not detected
Kidney	0	Not detected
Liver	0	Not detected
Lung	0	Not detected
Lymph node	0	Not detected
Nasopharynx	0	Not detected
Oral mucosa	0	Not detected
Ovary	0	Not detected
Pancreas	0	Not detected
Parathyroid gland	0	Not detected
Placenta	0	Not detected
Prostate	0	Not detected
Rectum	0	Not detected
Salivary gland	0	Not detected
Seminal vesicle	0	Not detected
Skeletal muscle	0	Not detected
Skin	0	Not detected
Small intestine	0	Not detected
Smooth muscle	0	Not detected
Soft tissue	0	Not detected
Spleen	0	Not detected
Stomach	0	Not detected
Testis	0	Not detected
Thyroid gland	0	Not detected
Tonsil	0	Not detected
Urinary bladder	0	Not detected
Vagina	0	Not detected

Summary
Symbol	KMT2E
Name	lysine methyltransferase 2E
Aliases	HDCMC04P; MLL5; myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila); NKp44L; histon ......
Location	7q22.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.554	NS	24476821
BRCA	Breast invasive carcinoma	521	5.35e-06	Significant	23000897
COAD	Colon adenocarcinoma	149	7.28e-05	Significant	22810696
GBM	Glioblastoma multiforme	157	0.00655	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	1.39e-06	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.00918	Significant	26536169
LGG	Brain Lower Grade Glioma	513	4.3e-06	Significant	26824661
LUAD	Lung adenocarcinoma	230	0.0549	NS	25079552
LUSC	Lung squamous cell carcinoma	178	0.41	NS	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.0118	Significant	21720365
PRAD	Prostate adenocarcinoma	333	0.733	NS	26544944
READ	Rectum adenocarcinoma	67	0.000893	Significant	22810696
SKCM	Skin Cutaneous Melanoma	315	0.223	NS	26091043
STAD	Stomach adenocarcinoma	277	0.0178	Significant	25079317
THCA	Thyroid carcinoma	391	0.00123	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.991	NS	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	0.873	0.529	NS
BRCA	Breast invasive carcinoma	1079	0.931	0.757	NS
CESC	Cervical and endocervical cancers	291	1.652	0.153	NS
COAD	Colon adenocarcinoma	439	1.6	0.132	NS
ESCA	Esophageal carcinoma	184	0.753	0.363	NS
GBM	Glioblastoma multiforme	158	0.834	0.463	NS
HNSC	Head and Neck squamous cell carcinoma	518	0.751	0.127	NS
KIRC	Kidney renal clear cell carcinoma	531	0.457	8e-04	Longer
KIRP	Kidney renal papillary cell carcinoma	287	2.871	0.0242	Shorter
LAML	Acute Myeloid Leukemia	149	0.545	0.039	Longer
LGG	Brain Lower Grade Glioma	511	0.742	0.248	NS
LIHC	Liver hepatocellular carcinoma	365	0.926	0.753	NS
LUAD	Lung adenocarcinoma	502	0.665	0.0511	NS
LUSC	Lung squamous cell carcinoma	494	0.794	0.217	NS
OV	Ovarian serous cystadenocarcinoma	303	1.503	0.0545	NS
PAAD	Pancreatic adenocarcinoma	177	1.375	0.272	NS
PCPG	Pheochromocytoma and Paraganglioma	179	3.992	0.199	NS
PRAD	Prostate adenocarcinoma	497	1.706	0.728	NS
READ	Rectum adenocarcinoma	159	1.165	0.765	NS
SARC	Sarcoma	259	0.763	0.346	NS
SKCM	Skin Cutaneous Melanoma	459	0.738	0.112	NS
STAD	Stomach adenocarcinoma	388	0.984	0.94	NS
TGCT	Testicular Germ Cell Tumors	134	1.074	0.96	NS
THCA	Thyroid carcinoma	500	1.468	0.672	NS
THYM	Thymoma	119	0.899	0.897	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	1.126	0.69	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	-0.041	0.408	NS
BRCA	Breast invasive carcinoma	1071	-0.048	0.119	NS
CESC	Cervical and endocervical cancers	167	-0.044	0.571	NS
COAD	Colon adenocarcinoma	445	0.117	0.0138	Higher
ESCA	Esophageal carcinoma	162	-0.091	0.251	NS
HNSC	Head and Neck squamous cell carcinoma	448	-0.043	0.367	NS
KIRC	Kidney renal clear cell carcinoma	531	-0.085	0.0502	NS
KIRP	Kidney renal papillary cell carcinoma	260	0.045	0.471	NS
LIHC	Liver hepatocellular carcinoma	347	0.063	0.243	NS
LUAD	Lung adenocarcinoma	507	-0.005	0.919	NS
LUSC	Lung squamous cell carcinoma	497	0.024	0.593	NS
OV	Ovarian serous cystadenocarcinoma	302	-0.023	0.696	NS
PAAD	Pancreatic adenocarcinoma	176	0.141	0.0612	NS
READ	Rectum adenocarcinoma	156	0.11	0.17	NS
SKCM	Skin Cutaneous Melanoma	410	-0.01	0.847	NS
STAD	Stomach adenocarcinoma	392	0.092	0.0678	NS
TGCT	Testicular Germ Cell Tumors	81	-0.255	0.0214	Lower
THCA	Thyroid carcinoma	499	-0.013	0.768	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	-0.006	0.901	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	-0.152	0.0118	Lower
HNSC	Head and Neck squamous cell carcinoma	498	0.136	0.00238	Higher
KIRC	Kidney renal clear cell carcinoma	525	-0.102	0.0192	Lower
LGG	Brain Lower Grade Glioma	514	0.021	0.629	NS
LIHC	Liver hepatocellular carcinoma	366	0.015	0.768	NS
OV	Ovarian serous cystadenocarcinoma	296	0.007	0.906	NS
PAAD	Pancreatic adenocarcinoma	176	-0.066	0.381	NS
STAD	Stomach adenocarcinoma	406	-0.048	0.336	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	-0.024	0.583	NS

Summary
Symbol	KMT2E
Name	lysine methyltransferase 2E
Aliases	HDCMC04P; MLL5; myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila); NKp44L; histon ......
Location	7q22.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	KMT2E
Name	lysine methyltransferase 2E
Aliases	HDCMC04P; MLL5; myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila); NKp44L; histon ......
Location	7q22.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for KMT2E.

Summary
Symbol	KMT2E
Name	lysine methyltransferase 2E
Aliases	HDCMC04P; MLL5; myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila); NKp44L; histon ......
Location	7q22.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]
There is no record for KMT2E.

> Interactions from Text Mining [ TOP ]
There is no record for KMT2E.