CR2Cancer

Summary
Symbol	MBD4
Name	methyl-CpG binding domain 4, DNA glycosylase
Aliases	methyl-CpG binding domain protein 4; 3,N(4)-ethenocytosine glycosylase; G/5-fluorouracil mismatch glycosylas ......
Location	3q21.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

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Domain

PF01429 Methyl-CpG binding domain

Function

Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein.

Classification

Class	Modification	Substrate	Product	PubMed
DNA modification	#	G:T, G:U	#	10930409

> Gene Ontology [ TOP ]
Biological Process	GO:0006220 pyrimidine nucleotide metabolic process GO:0006244 pyrimidine nucleotide catabolic process GO:0006284 base-excision repair GO:0006285 base-excision repair, AP site formation GO:0006304 DNA modification GO:0009166 nucleotide catabolic process GO:0009219 pyrimidine deoxyribonucleotide metabolic process GO:0009223 pyrimidine deoxyribonucleotide catabolic process GO:0009262 deoxyribonucleotide metabolic process GO:0009264 deoxyribonucleotide catabolic process GO:0009314 response to radiation GO:0009394 2'-deoxyribonucleotide metabolic process GO:0019439 aromatic compound catabolic process GO:0019692 deoxyribose phosphate metabolic process GO:0032355 response to estradiol GO:0034655 nucleobase-containing compound catabolic process GO:0044270 cellular nitrogen compound catabolic process GO:0045008 depyrimidination GO:0046386 deoxyribose phosphate catabolic process GO:0046434 organophosphate catabolic process GO:0046700 heterocycle catabolic process GO:0072527 pyrimidine-containing compound metabolic process GO:0072529 pyrimidine-containing compound catabolic process GO:1901136 carbohydrate derivative catabolic process GO:1901292 nucleoside phosphate catabolic process GO:1901361 organic cyclic compound catabolic process GO:1901565 organonitrogen compound catabolic process
Molecular Function	GO:0000700 mismatch base pair DNA N-glycosylase activity GO:0003696 satellite DNA binding GO:0004518 nuclease activity GO:0004519 endonuclease activity GO:0004520 endodeoxyribonuclease activity GO:0004536 deoxyribonuclease activity GO:0008263 pyrimidine-specific mismatch base pair DNA N-glycosylase activity GO:0016798 hydrolase activity, acting on glycosyl bonds GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds GO:0019104 DNA N-glycosylase activity
Cellular Component	GO:0000785 chromatin

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa03410 Base excision repair
Reactome	R-HSA-73884: Base Excision Repair R-HSA-73929: Base-Excision Repair, AP Site Formation R-HSA-110329: Cleavage of the damaged pyrimidine R-HSA-73894: DNA Repair R-HSA-73928: Depyrimidination R-HSA-110357: Displacement of DNA glycosylase by APEX1 R-HSA-110328: Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-73933: Resolution of Abasic Sites (AP sites)

> KEGG and Reactome Pathway

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KEGG

hsa03410 Base excision repair

Reactome

R-HSA-73884: Base Excision Repair
R-HSA-73929: Base-Excision Repair, AP Site Formation
R-HSA-110329: Cleavage of the damaged pyrimidine
R-HSA-73894: DNA Repair
R-HSA-73928: Depyrimidination
R-HSA-110357: Displacement of DNA glycosylase by APEX1
R-HSA-110328: Recognition and association of DNA glycosylase with site containing an affected pyrimidine
R-HSA-73933: Resolution of Abasic Sites (AP sites)

Summary
Symbol	MBD4
Name	methyl-CpG binding domain 4, DNA glycosylase
Aliases	methyl-CpG binding domain protein 4; 3,N(4)-ethenocytosine glycosylase; G/5-fluorouracil mismatch glycosylas ......
Location	3q21.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

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COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM3587200	c.1404G>A	p.R468R	Substitution - coding silent	Skin
COSM3408215	c.571C>T	p.P191S	Substitution - Missense	Prostate
COSM4403256	c.754A>T	p.K252*	Substitution - Nonsense	Skin
COSM1166724	c.896C>A	p.T299N	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1038084	c.247C>T	p.R83C	Substitution - Missense	Endometrium
COSM4700977	c.541C>T	p.R181*	Substitution - Nonsense	Large_intestine
COSM3060104	c.1242A>G	p.T414T	Substitution - coding silent	Large_intestine
COSM1752895	c.1087G>C	p.E363Q	Substitution - Missense	Urinary_tract
COSM5820287	c.616A>T	p.N206Y	Substitution - Missense	Liver
COSM4700975	c.1408T>G	p.S470A	Substitution - Missense	Large_intestine
COSM3759723	c.1413C>T	p.G471G	Substitution - coding silent	Large_intestine
COSM3729906	c.939delA	p.E314fs*4	Deletion - Frameshift	Stomach
COSM3729906	c.939delA	p.E314fs*4	Deletion - Frameshift	Large_intestine
COSM1741625	c.1139C>G	p.S380C	Substitution - Missense	Urinary_tract
COSM1495380	c.729T>A	p.I243I	Substitution - coding silent	Kidney
COSM5398118	c.1087G>A	p.E363K	Substitution - Missense	Skin
COSM5776285	c.1669C>G	p.H557D	Substitution - Missense	Breast
COSM1038082	c.404C>A	p.S135Y	Substitution - Missense	Endometrium
COSM1038077	c.1319C>A	p.P440H	Substitution - Missense	Endometrium
COSM1038086	c.61A>G	p.T21A	Substitution - Missense	Endometrium
COSM1327891	c.906G>C	p.V302V	Substitution - coding silent	Ovary
COSM1752895	c.1087G>C	p.E363Q	Substitution - Missense	Biliary_tract
COSM394505	c.501A>G	p.L167L	Substitution - coding silent	Lung
COSM3396517	c.1311A>G	p.K437K	Substitution - coding silent	Prostate
COSM13881	c.1418T>G	p.M473R	Substitution - Missense	Lung
COSM5002096	c.1702G>C	p.D568H	Substitution - Missense	Pancreas
COSM4533614	c.199G>A	p.E67K	Substitution - Missense	Skin
COSM4113324	c.187C>T	p.P63S	Substitution - Missense	Stomach
COSM3729906	c.939delA	p.E314fs*4	Deletion - Frameshift	Large_intestine
COSM581437	c.752G>T	p.R251M	Substitution - Missense	Large_intestine
COSM1257401	c.1056T>C	p.F352F	Substitution - coding silent	Oesophagus
COSM5636452	c.955T>C	p.S319P	Substitution - Missense	Oesophagus
COSM5729119	c.540C>T	p.T180T	Substitution - coding silent	Skin
COSM1257400	c.1483G>C	p.D495H	Substitution - Missense	Pancreas
COSM3729906	c.939delA	p.E314fs*4	Deletion - Frameshift	Large_intestine
COSM5708461	c.1276+2T>A	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM1752895	c.1087G>C	p.E363Q	Substitution - Missense	Urinary_tract
COSM4439945	c.992G>A	p.G331D	Substitution - Missense	Thyroid
COSM4700973	c.1721A>G	p.H574R	Substitution - Missense	Large_intestine
COSM4113323	c.350A>C	p.K117T	Substitution - Missense	Stomach
COSM728559	c.1501G>C	p.E501Q	Substitution - Missense	Lung
COSM240612	c.745G>A	p.G249R	Substitution - Missense	Prostate
COSM282693	c.393T>C	p.N131N	Substitution - coding silent	Large_intestine
COSM3774506	c.1737A>G	p.L579L	Substitution - coding silent	Urinary_tract
COSM3729906	c.939delA	p.E314fs*4	Deletion - Frameshift	Large_intestine
COSM5652790	c.1136G>T	p.G379V	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1186404	c.217C>T	p.Q73*	Substitution - Nonsense	Lung
COSM1418819	c.1534C>T	p.R512W	Substitution - Missense	Large_intestine
COSM1038078	c.1132C>T	p.R378C	Substitution - Missense	Endometrium
COSM5954002	c.1675G>C	p.E559Q	Substitution - Missense	Upper_aerodigestive_tract
COSM445546	c.1217G>A	p.R406Q	Substitution - Missense	Breast
COSM4113320	c.1318C>A	p.P440T	Substitution - Missense	Stomach
COSM5994673	c.1411+5G>T	p.?	Unknown	Prostate
COSM4113322	c.967T>G	p.F323V	Substitution - Missense	Stomach
COSM4113321	c.1245C>T	p.S415S	Substitution - coding silent	Stomach
COSM371419	c.546C>A	p.S182R	Substitution - Missense	Lung
COSM479397	c.1377T>C	p.L459L	Substitution - coding silent	Kidney
COSM3587203	c.159G>A	p.M53I	Substitution - Missense	Skin
COSM162402	c.240A>G	p.T80T	Substitution - coding silent	Breast
COSM479398	c.1264T>C	p.Y422H	Substitution - Missense	Kidney
COSM1693441	c.1554G>T	p.K518N	Substitution - Missense	Skin
COSM3729906	c.939delA	p.E314fs*4	Deletion - Frameshift	Large_intestine
COSM4700976	c.665A>G	p.D222G	Substitution - Missense	Large_intestine
COSM3695806	c.150G>T	p.E50D	Substitution - Missense	Large_intestine
COSM3060113	c.744delA	p.G249fs*54	Deletion - Frameshift	Large_intestine
COSM3729906	c.939delA	p.E314fs*4	Deletion - Frameshift	Large_intestine
COSM3408215	c.571C>T	p.P191S	Substitution - Missense	Central_nervous_system
COSM4807559	c.542G>A	p.R181Q	Substitution - Missense	Pancreas
COSM3060104	c.1242A>G	p.T414T	Substitution - coding silent	Large_intestine
COSM1038083	c.368C>A	p.S123*	Substitution - Nonsense	Endometrium
COSM5773901	c.1622G>A	p.G541D	Substitution - Missense	Breast
COSM3660178	c.1018A>G	p.K340E	Substitution - Missense	Liver
COSM4927075	c.997A>T	p.I333L	Substitution - Missense	Liver
COSM1038081	c.797C>A	p.S266Y	Substitution - Missense	Endometrium
COSM1038076	c.1325G>A	p.R442Q	Substitution - Missense	Endometrium
COSM4700974	c.1639A>T	p.I547F	Substitution - Missense	Large_intestine
COSM3846166	c.675C>T	p.F225F	Substitution - coding silent	Breast
COSM3729906	c.939delA	p.E314fs*4	Deletion - Frameshift	Large_intestine
COSM13881	c.1418T>G	p.M473R	Substitution - Missense	Lung
COSM1239416	c.326A>G	p.Y109C	Substitution - Missense	Oesophagus
COSM4777762	c.929_930insA	p.E314fs*13	Insertion - Frameshift	Prostate
COSM728558	c.1480G>A	p.A494T	Substitution - Missense	Lung
COSM325773	c.976G>T	p.E326*	Substitution - Nonsense	Lung
COSM1214639	c.104+1G>T	p.?	Unknown	Large_intestine
COSM5605870	c.1356T>A	p.L452L	Substitution - coding silent	Skin
COSM1495381	c.1448A>T	p.E483V	Substitution - Missense	Kidney
COSM1038075	c.1532_1534delTTC	p.L511delL	Deletion - In frame	Endometrium
COSM1038085	c.142G>T	p.E48*	Substitution - Nonsense	Endometrium
COSM1484585	c.58G>A	p.V20I	Substitution - Missense	Breast
COSM1752896	c.1027G>A	p.E343K	Substitution - Missense	Urinary_tract
COSM5678237	c.838C>G	p.Q280E	Substitution - Missense	Soft_tissue
COSM1038080	c.1048G>A	p.D350N	Substitution - Missense	Endometrium
COSM5965348	c.272A>G	p.E91G	Substitution - Missense	Breast
COSM1038079	c.1074C>T	p.I358I	Substitution - coding silent	Endometrium
COSM4840542	c.932A>C	p.K311T	Substitution - Missense	Cervix
COSM71585	c.1019A>G	p.K340R	Substitution - Missense	Ovary
COSM116704	c.1475G>C	p.R492T	Substitution - Missense	Ovary
COSM3729906	c.939delA	p.E314fs*4	Deletion - Frameshift	Large_intestine
COSM3060119	c.105-4C>T	p.?	Unknown	Skin
COSM3759723	c.1413C>T	p.G471G	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM4761254	c.1437G>T	p.W479C	Substitution - Missense	Stomach
COSM6011189	c.173G>T	p.S58I	Substitution - Missense	Skin
COSM4439945	c.992G>A	p.G331D	Substitution - Missense	Thyroid
COSM4568477	c.116T>C	p.V39A	Substitution - Missense	Skin
COSM5508678	c.1141G>A	p.E381K	Substitution - Missense	Biliary_tract
COSM4978327	c.458C>G	p.S153*	Substitution - Nonsense	Oesophagus
COSM331349	c.1168_1169AG>TT	p.R390>?	Complex	Lung
COSM3396517	c.1311A>G	p.K437K	Substitution - coding silent	Prostate
COSM479396	c.1709T>C	p.L570P	Substitution - Missense	Kidney
COSM3587201	c.1324C>T	p.R442W	Substitution - Missense	Skin
COSM5398119	c.447G>A	p.R149R	Substitution - coding silent	Skin
COSM5950618	c.1481C>T	p.A494V	Substitution - Missense	Prostate
COSM13881	c.1418T>G	p.M473R	Substitution - Missense	Lung
COSM1257400	c.1483G>C	p.D495H	Substitution - Missense	Oesophagus
COSM4831603	c.1597G>T	p.E533*	Substitution - Nonsense	Cervix
COSM3729906	c.939delA	p.E314fs*4	Deletion - Frameshift	Large_intestine
COSM1752897	c.1025C>G	p.S342*	Substitution - Nonsense	Urinary_tract
COSM3759724	c.817G>A	p.A273T	Substitution - Missense	Large_intestine
COSM3587202	c.357A>G	p.R119R	Substitution - coding silent	Skin
COSM1257399	c.1298A>G	p.K433R	Substitution - Missense	Stomach
COSM226087	c.1387A>G	p.T463A	Substitution - Missense	Skin

> Text Mining based Variations

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PMID	Variation	Cancer	Evidence
26503472	Mutation	Colorectal Neoplasm	We investigated MBD4 variants in a large series of hereditary/familial and sporadic CRC cases. Whereas MBD4 frameshifts were only detected in tumors, missense variants were found in both normal and tumor DNA.
19179424	Mutation	medulloblastomas	The MSI target genes MBD4 (methyl-CpG binding domain protein 4) and MRE11 (meiotic recombination 11 homolog A) were mutated in two different tumors. No CTNNB1 or BRAF mutations were found. This study is the most comprehensive analysis of MSI in medulloblastomas to date.
18206535	Mutation	Gastric Carcinoma	We aimed to investigate which MMR defects are present in SGC. Twenty-nine MSI-H SGC investigated previously for MLH1 promoter hypermethylation were screened for somatic mutations in MLH1, MSH2, MSH6, MLH3, and MBD4 by denaturing gradient gel electrophoresis and sequencing. Five truncating mutations (three in MSH6, one in MLH3, and one in MBD4) and one missense mutation (MLH1) were identified
18162445	Mutation	Colon Carcinoma	A strong candidate identified through this approach was MBD4 as it showed a homozygous truncating mutation associated with substantial loss of the transcript in HCA7 not seen in the other lines.
17384679	Mutation	Colorectal Neoplasm	We here screened 39 MSI colorectal tumours for the presence of mutations in 25 genes involved in DNA damage signalling and repair pathways. Using a maximum likelihood statistical method, these genes were divided into two different groups that differed significantly in their mutation frequencies, and likely represent mutations that do or do not provide selective pressure during MSI tumour progression. Interestingly, the so-called real-target mutational events were found to be distributed among genes involved in different functional pathways of the DNA metabolism, for example, DNA damage signalling (DNA-PKcs, ATR), double-strand break (DSB) repair (DNA-PKcs, RAD50), mismatch repair (MSH3, MSH6, MBD4) and replication (POLD3).
17285135	Mutation	Colorectal Carcinoma	We now show that recombinant truncated MBD4 (MBD4(tru)) inhibits glycosylase activities of normal MBD4 or Uracil DNA glycosylase in cell-free assays as a dominant negative effect. Furthermore, overexpression of MBD4(tru) in Big Blue (lacI)-transfected, MSI human colorectal carcinoma cells doubled mutation frequency, indicating that the modest dominant negative effect on DNA repair can occur in living cells in short-term experiments.
16803845	Mutation	Lung Carcinoma	The distribution of the MBD4 Glu346Lys genotypes was not significantly different between the overall lung cancer cases and the controls. However, when the cases were categorized by tumor histology, the Lys346Lys genotype was associated with a significantly decreased risk of adenocarcinoma (AC) as compared with the Glu346Glu genotype [adjusted odds ratio (OR) = 0.50, 95% confidence interval (CI) = 0.26-0.97, P = 0.04]. On the stratification analysis, the protective effect of the Lys346Lys genotype against AC was statistically significant in older individuals and heavier smokers (adjusted OR = 0.08, 95% CI = 0.01-0.64, P = 0.02; and adjusted OR = 0.09, 95% CI = 0.01-0.72, P = 0.02, respectively).
16421660	Mutation	Hereditary Nonpolyposis Colorectal Cancer	Thirty-one colorectal cancers from patients with hereditary nonpolyposis colorectal cancer at different clinicopathologic stages were analyzed for frameshift mutation in 18 genes. Mutations of the hMSH3, TCF4, CASP5, RIZ, RAD50, and MBD4 genes were comparatively frequent (>35 percent) in all stages.
16288216	Mutation	upper urinary tract urothelial cell carcinoma	Mutations in genes involved in key cellular pathways (ATR, DNA-PKcs, MBD4, TCF-4, MSH6, and BLM) were further detected.
12430186	Mutation	Gastric Carcinoma; Colon Carcinoma	MBD4/MED1 is mutated in gastric cancers as frequently as in colon cancers; these mutations reduce the accuracy of DNA repair, and may lead to cancer progression.
11526511	Mutation	Hereditary Nonpolyposis Colorectal Cancer	We analysed alterations at repeated sequences of coding regions, as well as those of 5' upstream regions, in 29 MSI-High colorectal tumors from patients with hereditary nonpolyposis colorectal cancer (HNPCC) and Turcot syndrome. Alteration at repeated sequences in the coding regions were 72% at TGFbetaRII(A)10, 24% at IGFIIR(G)8, 45% at BAX(G)8, 55% at E2F4(CAG)13, 66% at caspase-5 (A)10, 31% at MBD4(A)10, 55% at hMSH3(A)8 and 34% at hMSH6(C)8.
11104560	Mutation	Colon Carcinoma	In microsatellite unstable tumours MBD4 can itself be mutated at an exonic polynucleotide tract. By analysing DNA from microdissected tumour samples we have found that both frequency and pattern of mutation are more significant than originally reported.
10637515	Mutation	Colon Carcinoma	We describe here frameshift mutations affecting the gene for the methyl-CpG binding thymine glycosylase, MBD4, in over 40% of microsatellite unstable sporadic colon cancers.

Summary
Symbol	MBD4
Name	methyl-CpG binding domain 4, DNA glycosylase
Aliases	methyl-CpG binding domain protein 4; 3,N(4)-ethenocytosine glycosylase; G/5-fluorouracil mismatch glycosylas ......
Location	3q21.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

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Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
O95243	428	S	Phosphoserine	-	No	None detected

Summary
Symbol	MBD4
Name	methyl-CpG binding domain 4, DNA glycosylase
Aliases	methyl-CpG binding domain protein 4; 3,N(4)-ethenocytosine glycosylase; G/5-fluorouracil mismatch glycosylas ......
Location	3q21.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

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Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	4.965	5.15	0.228	0.0534	NS
BRCA	Breast invasive carcinoma	112	1100	5.203	5.504	0.36	2.11e-18	NS
CESC	Cervical and endocervical cancers	3	306	5.167	5.813	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	4.871	4.861	-0.097	0.319	NS
ESCA	Esophageal carcinoma	11	185	4.526	5.077	0.503	0.00755	NS
GBM	Glioblastoma multiforme	5	166	5.004	4.956	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	4.644	5.128	0.542	4.65e-12	NS
KIRC	Kidney renal clear cell carcinoma	72	534	5.157	5.19	-0.027	0.594	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	4.999	5.123	0.04	0.656	NS
LAML	Acute Myeloid Leukemia	0	173	NA	6.247	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	4.673	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	4.79	4.569	-0.172	0.0277	NS
LUAD	Lung adenocarcinoma	59	517	5.156	5.287	0.141	0.0193	NS
LUSC	Lung squamous cell carcinoma	51	501	5.115	5.649	0.513	1.37e-13	NS
OV	Ovarian serous cystadenocarcinoma	0	307	NA	5.529	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	5.161	5.201	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	4.894	4.582	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	4.891	4.843	-0.031	0.524	NS
READ	Rectum adenocarcinoma	10	167	4.927	4.887	-0.137	0.553	NS
SARC	Sarcoma	2	263	5.139	5.058	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	5.752	4.818	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	4.897	5.007	0.105	0.276	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	5.27	NA	NA	NA
THCA	Thyroid carcinoma	59	509	5.106	5.241	0.097	0.0183	NS
THYM	Thymoma	2	120	5.671	5.558	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	5.138	5.108	0.037	0.755	NS

> Cancer Cell Line Encyclopedia (CCLE)

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Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	9.1
Autonomic ganglia	CHP212	9.6
Autonomic ganglia	IMR32	9.7
Autonomic ganglia	KELLY	10.3
Autonomic ganglia	KPNRTBM1	9.4
Autonomic ganglia	KPNSI9S	9.7
Autonomic ganglia	KPNYN	9.4
Autonomic ganglia	MHHNB11	9.3
Autonomic ganglia	NB1	8.8
Autonomic ganglia	NH6	9.5
Autonomic ganglia	SHSY5Y	9.3
Autonomic ganglia	SIMA	9.2
Autonomic ganglia	SKNAS	9.2
Autonomic ganglia	SKNBE2	9.7
Autonomic ganglia	SKNDZ	10
Autonomic ganglia	SKNFI	9.2
Autonomic ganglia	SKNSH	9.2
Biliary tract	HUCCT1	9.7
Biliary tract	HUH28	10.5
Biliary tract	SNU1079	9.1
Biliary tract	SNU1196	9.1
Biliary tract	SNU245	9
Biliary tract	SNU308	9.9
Biliary tract	SNU478	9.2
Bone	143B	9.8
Bone	A673	9.8
Bone	CADOES1	9.2
Bone	CAL78	10
Bone	G292CLONEA141B1	9.8
Bone	HOS	9.5
Bone	HS706T	9.7
Bone	HS737T	9.4
Bone	HS819T	9.8
Bone	HS821T	9
Bone	HS822T	9.8
Bone	HS863T	9.3
Bone	HS870T	9.6
Bone	HS888T	9.3
Bone	MG63	9.9
Bone	MHHES1	9.9
Bone	OUMS27	9.4
Bone	RDES	8.9
Bone	SJSA1	9.5
Bone	SKES1	10.1
Bone	SKNMC	10.9
Bone	SW1353	9.3
Bone	T173	9.7
Bone	TC71	10.3
Bone	U2OS	9.7
Breast	AU565	9.7
Breast	BT20	10.8
Breast	BT474	9.9
Breast	BT483	9.8
Breast	BT549	9.8
Breast	CAL120	9.1
Breast	CAL148	9.9
Breast	CAL51	9.5
Breast	CAL851	9.6
Breast	CAMA1	10.3
Breast	DU4475	9.8
Breast	EFM192A	9.7
Breast	EFM19	10.4
Breast	EVSAT	9.7
Breast	HCC1143	10.3
Breast	HCC1187	9.8
Breast	HCC1395	10.1
Breast	HCC1419	9.5
Breast	HCC1428	10
Breast	HCC1500	9.7
Breast	HCC1569	10.2
Breast	HCC1599	10.2
Breast	HCC1806	10.3
Breast	HCC1937	10.1
Breast	HCC1954	9.9
Breast	HCC202	10.1
Breast	HCC2157	9.7
Breast	HCC2218	8.4
Breast	HCC38	10.1
Breast	HCC70	10.6
Breast	HDQP1	9
Breast	HMC18	10.2
Breast	HS274T	9.3
Breast	HS281T	9
Breast	HS343T	9.5
Breast	HS578T	9.8
Breast	HS606T	9.7
Breast	HS739T	9.6
Breast	HS742T	9.7
Breast	JIMT1	9.5
Breast	KPL1	10.2
Breast	MCF7	10.4
Breast	MDAMB134VI	9.8
Breast	MDAMB157	9.9
Breast	MDAMB175VII	9.7
Breast	MDAMB231	8.9
Breast	MDAMB361	9.8
Breast	MDAMB415	9.2
Breast	MDAMB436	9
Breast	MDAMB453	9.8
Breast	MDAMB468	10
Breast	SKBR3	9.2
Breast	T47D	9.9
Breast	UACC812	9.4
Breast	UACC893	10
Breast	YMB1	9.9
Breast	ZR751	10
Breast	ZR7530	9
Central nervous system	1321N1	9.9
Central nervous system	42MGBA	9.4
Central nervous system	8MGBA	10.2
Central nervous system	A172	10.7
Central nervous system	AM38	9.8
Central nervous system	BECKER	10.6
Central nervous system	CAS1	9.9
Central nervous system	CCFSTTG1	10.3
Central nervous system	D283MED	9
Central nervous system	D341MED	8.6
Central nervous system	DAOY	9.7
Central nervous system	DBTRG05MG	9.2
Central nervous system	DKMG	9.3
Central nervous system	GAMG	9.8
Central nervous system	GB1	9.8
Central nervous system	GI1	9.3
Central nervous system	GMS10	10.2
Central nervous system	GOS3	9.7
Central nervous system	H4	10
Central nervous system	HS683	9.7
Central nervous system	KALS1	9.6
Central nervous system	KG1C	9.7
Central nervous system	KNS42	10
Central nervous system	KNS60	9.6
Central nervous system	KNS81	9.7
Central nervous system	KS1	9.3
Central nervous system	LN18	10
Central nervous system	LN229	9.6
Central nervous system	M059K	9.6
Central nervous system	MOGGCCM	10
Central nervous system	MOGGUVW	9.2
Central nervous system	NMCG1	9
Central nervous system	ONS76	9.7
Central nervous system	SF126	10.1
Central nervous system	SF295	10
Central nervous system	SNB19	9.9
Central nervous system	SNU1105	9.7
Central nervous system	SNU201	10.8
Central nervous system	SNU466	9.3
Central nervous system	SNU489	9.1
Central nervous system	SNU626	9.1
Central nervous system	SNU738	9.1
Central nervous system	SW1088	10
Central nervous system	SW1783	9.2
Central nervous system	T98G	9.6
Central nervous system	TM31	9.2
Central nervous system	U118MG	9.7
Central nervous system	U138MG	9.5
Central nervous system	U251MG	9.8
Central nervous system	U87MG	9.2
Central nervous system	YH13	9.5
Central nervous system	YKG1	9.7
Endometrium	AN3CA	10.2
Endometrium	COLO684	9.2
Endometrium	EFE184	9.3
Endometrium	EN	9.7
Endometrium	ESS1	10.7
Endometrium	HEC108	8.7
Endometrium	HEC151	9.2
Endometrium	HEC1A	9.7
Endometrium	HEC1B	9.9
Endometrium	HEC251	10
Endometrium	HEC265	9.5
Endometrium	HEC50B	9.5
Endometrium	HEC59	8.9
Endometrium	HEC6	9.5
Endometrium	ISHIKAWAHERAKLIO02ER	9.9
Endometrium	JHUEM1	8.8
Endometrium	JHUEM2	9.9
Endometrium	JHUEM3	9.3
Endometrium	KLE	9.3
Endometrium	MFE280	10
Endometrium	MFE296	9.8
Endometrium	MFE319	9.4
Endometrium	RL952	9.5
Endometrium	SNGM	9.3
Endometrium	SNU1077	9.2
Endometrium	SNU685	8.5
Endometrium	TEN	10.1
Haematopoietic and lymphoid	697	9.7
Haematopoietic and lymphoid	A3KAW	10.1
Haematopoietic and lymphoid	A4FUK	10.4
Haematopoietic and lymphoid	ALLSIL	10
Haematopoietic and lymphoid	AML193	11.3
Haematopoietic and lymphoid	AMO1	9.9
Haematopoietic and lymphoid	BCP1	10.2
Haematopoietic and lymphoid	BDCM	10.1
Haematopoietic and lymphoid	BL41	9.9
Haematopoietic and lymphoid	BL70	10.8
Haematopoietic and lymphoid	BV173	10.4
Haematopoietic and lymphoid	CA46	11
Haematopoietic and lymphoid	CI1	10.6
Haematopoietic and lymphoid	CMK115	9.6
Haematopoietic and lymphoid	CMK86	9.8
Haematopoietic and lymphoid	CMK	9.6
Haematopoietic and lymphoid	CMLT1	9.9
Haematopoietic and lymphoid	COLO775	9.5
Haematopoietic and lymphoid	DAUDI	11
Haematopoietic and lymphoid	DB	9.4
Haematopoietic and lymphoid	DEL	9.8
Haematopoietic and lymphoid	DND41	9.7
Haematopoietic and lymphoid	DOHH2	11.5
Haematopoietic and lymphoid	EB1	11.1
Haematopoietic and lymphoid	EB2	11
Haematopoietic and lymphoid	EHEB	10.3
Haematopoietic and lymphoid	EJM	10.3
Haematopoietic and lymphoid	EM2	11.1
Haematopoietic and lymphoid	EOL1	10.3
Haematopoietic and lymphoid	F36P	10.6
Haematopoietic and lymphoid	GA10	10.6
Haematopoietic and lymphoid	GDM1	10
Haematopoietic and lymphoid	GRANTA519	10.6
Haematopoietic and lymphoid	HDLM2	9.7
Haematopoietic and lymphoid	HDMYZ	9.1
Haematopoietic and lymphoid	HEL9217	9.5
Haematopoietic and lymphoid	HEL	9.7
Haematopoietic and lymphoid	HH	11.1
Haematopoietic and lymphoid	HL60	10.5
Haematopoietic and lymphoid	HPBALL	10
Haematopoietic and lymphoid	HS604T	9.2
Haematopoietic and lymphoid	HS611T	11.2
Haematopoietic and lymphoid	HS616T	9.4
Haematopoietic and lymphoid	HS751T	9.4
Haematopoietic and lymphoid	HT	11.6
Haematopoietic and lymphoid	HTK	9.2
Haematopoietic and lymphoid	HUNS1	10
Haematopoietic and lymphoid	HUT102	10.5
Haematopoietic and lymphoid	HUT78	10.4
Haematopoietic and lymphoid	JEKO1	10
Haematopoietic and lymphoid	JK1	10.7
Haematopoietic and lymphoid	JM1	10
Haematopoietic and lymphoid	JURKAT	10.2
Haematopoietic and lymphoid	JURLMK1	10.7
Haematopoietic and lymphoid	JVM2	11.2
Haematopoietic and lymphoid	JVM3	10.7
Haematopoietic and lymphoid	K562	10
Haematopoietic and lymphoid	KARPAS299	10.3
Haematopoietic and lymphoid	KARPAS422	10.7
Haematopoietic and lymphoid	KARPAS620	9.9
Haematopoietic and lymphoid	KASUMI1	10.7
Haematopoietic and lymphoid	KASUMI2	10.1
Haematopoietic and lymphoid	KASUMI6	10.5
Haematopoietic and lymphoid	KCL22	9.6
Haematopoietic and lymphoid	KE37	10
Haematopoietic and lymphoid	KE97	10
Haematopoietic and lymphoid	KG1	10.5
Haematopoietic and lymphoid	KHM1B	9.9
Haematopoietic and lymphoid	KIJK	10.2
Haematopoietic and lymphoid	KMH2	9.1
Haematopoietic and lymphoid	KMM1	9.8
Haematopoietic and lymphoid	KMS11	10.6
Haematopoietic and lymphoid	KMS12BM	10.4
Haematopoietic and lymphoid	KMS18	10.1
Haematopoietic and lymphoid	KMS20	10.2
Haematopoietic and lymphoid	KMS21BM	9.9
Haematopoietic and lymphoid	KMS26	10.2
Haematopoietic and lymphoid	KMS27	10.1
Haematopoietic and lymphoid	KMS28BM	10.3
Haematopoietic and lymphoid	KMS34	10.4
Haematopoietic and lymphoid	KO52	10.1
Haematopoietic and lymphoid	KOPN8	10.3
Haematopoietic and lymphoid	KU812	9.5
Haematopoietic and lymphoid	KYO1	10
Haematopoietic and lymphoid	L1236	10
Haematopoietic and lymphoid	L363	10.9
Haematopoietic and lymphoid	L428	9.4
Haematopoietic and lymphoid	L540	10
Haematopoietic and lymphoid	LAMA84	10.6
Haematopoietic and lymphoid	LOUCY	10.3
Haematopoietic and lymphoid	LP1	10.4
Haematopoietic and lymphoid	M07E	10.2
Haematopoietic and lymphoid	MC116	10.7
Haematopoietic and lymphoid	ME1	9
Haematopoietic and lymphoid	MEC1	10.4
Haematopoietic and lymphoid	MEC2	10.4
Haematopoietic and lymphoid	MEG01	10.2
Haematopoietic and lymphoid	MHHCALL2	10.3
Haematopoietic and lymphoid	MHHCALL3	10.4
Haematopoietic and lymphoid	MHHCALL4	10.3
Haematopoietic and lymphoid	MINO	9.3
Haematopoietic and lymphoid	MJ	10
Haematopoietic and lymphoid	MM1S	10.4
Haematopoietic and lymphoid	MOLM13	10.4
Haematopoietic and lymphoid	MOLM16	10.2
Haematopoietic and lymphoid	MOLM6	10.3
Haematopoietic and lymphoid	MOLP2	9.3
Haematopoietic and lymphoid	MOLP8	9.9
Haematopoietic and lymphoid	MOLT13	10.2
Haematopoietic and lymphoid	MOLT16	10.2
Haematopoietic and lymphoid	MOLT4	10.3
Haematopoietic and lymphoid	MONOMAC1	10.4
Haematopoietic and lymphoid	MONOMAC6	10.5
Haematopoietic and lymphoid	MOTN1	10.3
Haematopoietic and lymphoid	MUTZ5	10.1
Haematopoietic and lymphoid	MV411	10
Haematopoietic and lymphoid	NALM19	9.8
Haematopoietic and lymphoid	NALM1	10.2
Haematopoietic and lymphoid	NALM6	10.6
Haematopoietic and lymphoid	NAMALWA	10.6
Haematopoietic and lymphoid	NB4	10.3
Haematopoietic and lymphoid	NCIH929	10.4
Haematopoietic and lymphoid	NCO2	10.9
Haematopoietic and lymphoid	NOMO1	10.9
Haematopoietic and lymphoid	NUDHL1	9.6
Haematopoietic and lymphoid	NUDUL1	10
Haematopoietic and lymphoid	OCIAML2	10.8
Haematopoietic and lymphoid	OCIAML3	9.7
Haematopoietic and lymphoid	OCIAML5	10.4
Haematopoietic and lymphoid	OCILY10	10.5
Haematopoietic and lymphoid	OCILY19	9.7
Haematopoietic and lymphoid	OCILY3	10.4
Haematopoietic and lymphoid	OCIM1	10.8
Haematopoietic and lymphoid	OPM2	10.9
Haematopoietic and lymphoid	P12ICHIKAWA	10.3
Haematopoietic and lymphoid	P31FUJ	10.8
Haematopoietic and lymphoid	P3HR1	11.5
Haematopoietic and lymphoid	PCM6	10.6
Haematopoietic and lymphoid	PEER	10.3
Haematopoietic and lymphoid	PF382	10.5
Haematopoietic and lymphoid	PFEIFFER	10.3
Haematopoietic and lymphoid	PL21	10.8
Haematopoietic and lymphoid	RAJI	10.3
Haematopoietic and lymphoid	RCHACV	9.7
Haematopoietic and lymphoid	REC1	10.2
Haematopoietic and lymphoid	REH	10.2
Haematopoietic and lymphoid	RI1	10.8
Haematopoietic and lymphoid	RL	10.5
Haematopoietic and lymphoid	RPMI8226	10
Haematopoietic and lymphoid	RPMI8402	10.8
Haematopoietic and lymphoid	RS411	9.9
Haematopoietic and lymphoid	SEM	10.1
Haematopoietic and lymphoid	SET2	10.2
Haematopoietic and lymphoid	SIGM5	10.6
Haematopoietic and lymphoid	SKM1	10.3
Haematopoietic and lymphoid	SKMM2	9.9
Haematopoietic and lymphoid	SR786	10.2
Haematopoietic and lymphoid	ST486	10.2
Haematopoietic and lymphoid	SUDHL10	10
Haematopoietic and lymphoid	SUDHL1	10.1
Haematopoietic and lymphoid	SUDHL4	10.3
Haematopoietic and lymphoid	SUDHL5	10.8
Haematopoietic and lymphoid	SUDHL6	10.2
Haematopoietic and lymphoid	SUDHL8	9.8
Haematopoietic and lymphoid	SUPB15	10.3
Haematopoietic and lymphoid	SUPHD1	9.8
Haematopoietic and lymphoid	SUPM2	10.4
Haematopoietic and lymphoid	SUPT11	10.4
Haematopoietic and lymphoid	SUPT1	10.3
Haematopoietic and lymphoid	TALL1	10.2
Haematopoietic and lymphoid	TF1	10
Haematopoietic and lymphoid	THP1	10.7
Haematopoietic and lymphoid	TO175T	9.8
Haematopoietic and lymphoid	TOLEDO	10.3
Haematopoietic and lymphoid	U266B1	9.7
Haematopoietic and lymphoid	U937	9.8
Haematopoietic and lymphoid	UT7	9.7
Haematopoietic and lymphoid	WSUDLCL2	11
Kidney	769P	9.1
Kidney	786O	8.9
Kidney	A498	9.1
Kidney	A704	10
Kidney	ACHN	9.2
Kidney	BFTC909	10
Kidney	CAKI1	9.7
Kidney	CAKI2	9.1
Kidney	CAL54	10.1
Kidney	KMRC1	9.4
Kidney	KMRC20	10.1
Kidney	KMRC2	8.9
Kidney	KMRC3	9.5
Kidney	OSRC2	9.6
Kidney	RCC10RGB	9.7
Kidney	SNU1272	9.4
Kidney	SNU349	9.5
Kidney	TUHR10TKB	8.6
Kidney	TUHR14TKB	10.3
Kidney	TUHR4TKB	9.7
Kidney	VMRCRCW	9.6
Kidney	VMRCRCZ	9.7
Large intestine	C2BBE1	9.4
Large intestine	CCK81	10.2
Large intestine	CL11	9.4
Large intestine	CL14	9.4
Large intestine	CL34	9.1
Large intestine	CL40	8.6
Large intestine	COLO205	10.2
Large intestine	COLO320	9.6
Large intestine	COLO678	10.1
Large intestine	CW2	8.8
Large intestine	DLD1	9.6
Large intestine	GP2D	10.3
Large intestine	HCC56	10.4
Large intestine	HCT116	8.9
Large intestine	HCT15	9.9
Large intestine	HS675T	9.4
Large intestine	HS698T	9.3
Large intestine	HT115	9.7
Large intestine	HT29	10.2
Large intestine	HT55	9.6
Large intestine	KM12	10.1
Large intestine	LOVO	9.9
Large intestine	LS1034	10
Large intestine	LS123	9.4
Large intestine	LS180	9.8
Large intestine	LS411N	10
Large intestine	LS513	9.1
Large intestine	MDST8	8.9
Large intestine	NCIH508	9.9
Large intestine	NCIH716	9.2
Large intestine	NCIH747	10.3
Large intestine	OUMS23	10.9
Large intestine	RCM1	9.8
Large intestine	RKO	10.2
Large intestine	SKCO1	9.5
Large intestine	SNU1040	8.8
Large intestine	SNU1197	10.2
Large intestine	SNU175	9.7
Large intestine	SNU283	9.4
Large intestine	SNU407	9.5
Large intestine	SNU503	10.1
Large intestine	SNU61	10
Large intestine	SNU81	9.8
Large intestine	SNUC1	9.9
Large intestine	SNUC2A	10.5
Large intestine	SNUC4	9.8
Large intestine	SNUC5	9.2
Large intestine	SW1116	10
Large intestine	SW1417	9.9
Large intestine	SW1463	9.4
Large intestine	SW403	9.8
Large intestine	SW480	9.9
Large intestine	SW48	10.2
Large intestine	SW620	9.5
Large intestine	SW837	9.9
Large intestine	SW948	9.7
Large intestine	T84	9.7
Liver	ALEXANDERCELLS	9.1
Liver	C3A	9.1
Liver	HEP3B217	9.8
Liver	HEPG2	8.8
Liver	HLE	9.1
Liver	HLF	9.2
Liver	HUH1	9.9
Liver	HUH6	10
Liver	HUH7	9.9
Liver	JHH1	9.7
Liver	JHH2	9.7
Liver	JHH4	9.3
Liver	JHH5	9.3
Liver	JHH6	9.5
Liver	JHH7	9.6
Liver	LI7	9.5
Liver	PLCPRF5	9
Liver	SKHEP1	9.1
Liver	SNU182	8.9
Liver	SNU387	10
Liver	SNU398	9.5
Liver	SNU423	9.4
Liver	SNU449	8.8
Liver	SNU475	9.6
Liver	SNU761	9.5
Liver	SNU878	9.6
Liver	SNU886	9.6
Lung	A549	9.4
Lung	ABC1	10.2
Lung	BEN	9
Lung	CAL12T	10
Lung	CALU1	9.4
Lung	CALU3	9.9
Lung	CALU6	9.8
Lung	CHAGOK1	10.3
Lung	COLO668	9.7
Lung	COLO699	9.4
Lung	CORL105	9.5
Lung	CORL23	10.9
Lung	CORL24	10.5
Lung	CORL279	10.5
Lung	CORL311	10.3
Lung	CORL47	10
Lung	CORL51	10.7
Lung	CORL88	10.2
Lung	CORL95	9.7
Lung	CPCN	11
Lung	DMS114	9.8
Lung	DMS153	10.5
Lung	DMS273	9.9
Lung	DMS454	9.8
Lung	DMS53	9.6
Lung	DMS79	10.4
Lung	DV90	9.1
Lung	EBC1	10.5
Lung	EPLC272H	10
Lung	HARA	10
Lung	HCC1171	9.3
Lung	HCC1195	9.7
Lung	HCC15	9.1
Lung	HCC2279	9.3
Lung	HCC2935	9.6
Lung	HCC33	10.6
Lung	HCC366	10
Lung	HCC4006	9.7
Lung	HCC44	9.7
Lung	HCC78	10.1
Lung	HCC827	9.3
Lung	HCC95	9.2
Lung	HLC1	10.3
Lung	HLFA	9.1
Lung	HS229T	9.8
Lung	HS618T	9.5
Lung	IALM	8.9
Lung	KNS62	9.2
Lung	LC1F	9.8
Lung	LC1SQSF	10.2
Lung	LCLC103H	9.2
Lung	LCLC97TM1	9.9
Lung	LK2	9.9
Lung	LOUNH91	9.3
Lung	LU65	9.8
Lung	LU99	9.6
Lung	LUDLU1	9.8
Lung	LXF289	9.8
Lung	MORCPR	10.8
Lung	NCIH1048	10.1
Lung	NCIH1092	10.1
Lung	NCIH1105	11.3
Lung	NCIH1155	10.1
Lung	NCIH1184	10.2
Lung	NCIH1299	10
Lung	NCIH1339	10
Lung	NCIH1341	9.5
Lung	NCIH1355	9.7
Lung	NCIH1373	10.3
Lung	NCIH1385	8.8
Lung	NCIH1395	8.1
Lung	NCIH1435	10.1
Lung	NCIH1436	10.9
Lung	NCIH1437	10.5
Lung	NCIH146	10.4
Lung	NCIH1563	10.3
Lung	NCIH1568	9.5
Lung	NCIH1573	9.9
Lung	NCIH1581	9.4
Lung	NCIH1618	10
Lung	NCIH1623	10.5
Lung	NCIH1648	10.2
Lung	NCIH1650	9.6
Lung	NCIH1651	9.3
Lung	NCIH1666	11.1
Lung	NCIH1693	9.3
Lung	NCIH1694	10.1
Lung	NCIH1703	9.9
Lung	NCIH1734	10.2
Lung	NCIH1755	9.5
Lung	NCIH1781	10.8
Lung	NCIH1792	9.1
Lung	NCIH1793	10.3
Lung	NCIH1836	10.7
Lung	NCIH1838	9.4
Lung	NCIH1869	9.8
Lung	NCIH1876	10.8
Lung	NCIH1915	9.9
Lung	NCIH1930	10
Lung	NCIH1944	9.5
Lung	NCIH1963	10
Lung	NCIH196	10.6
Lung	NCIH1975	9.8
Lung	NCIH2009	9.2
Lung	NCIH2023	10.1
Lung	NCIH2029	9.8
Lung	NCIH2030	8.8
Lung	NCIH2066	10.5
Lung	NCIH2081	10.6
Lung	NCIH2085	9.4
Lung	NCIH2087	10.6
Lung	NCIH209	10.1
Lung	NCIH2106	9.9
Lung	NCIH2110	10.2
Lung	NCIH211	9.9
Lung	NCIH2122	8.8
Lung	NCIH2126	9.5
Lung	NCIH2141	9.6
Lung	NCIH2170	8.9
Lung	NCIH2171	10.7
Lung	NCIH2172	9.8
Lung	NCIH2196	11.2
Lung	NCIH2227	8.9
Lung	NCIH2228	10.3
Lung	NCIH226	9.7
Lung	NCIH2286	10
Lung	NCIH2291	9.8
Lung	NCIH2342	9.7
Lung	NCIH2347	10.2
Lung	NCIH23	10.3
Lung	NCIH2405	9.4
Lung	NCIH2444	10.3
Lung	NCIH292	9.3
Lung	NCIH322	9.1
Lung	NCIH3255	10
Lung	NCIH358	9.5
Lung	NCIH441	10.5
Lung	NCIH446	10
Lung	NCIH460	9.3
Lung	NCIH510	9.4
Lung	NCIH520	10.4
Lung	NCIH522	9.9
Lung	NCIH524	10
Lung	NCIH526	10.5
Lung	NCIH596	10.1
Lung	NCIH647	9.7
Lung	NCIH650	9.2
Lung	NCIH661	9.4
Lung	NCIH69	9.6
Lung	NCIH727	9
Lung	NCIH810	10.2
Lung	NCIH82	9.8
Lung	NCIH838	10.4
Lung	NCIH841	9.3
Lung	NCIH854	8.2
Lung	NCIH889	9.9
Lung	PC14	9.7
Lung	RERFLCAD1	10.3
Lung	RERFLCAD2	9.3
Lung	RERFLCAI	10.2
Lung	RERFLCKJ	9.7
Lung	RERFLCMS	9.9
Lung	RERFLCSQ1	10.1
Lung	SBC5	9.6
Lung	SCLC21H	10.1
Lung	SHP77	9.2
Lung	SKLU1	9.4
Lung	SKMES1	9.5
Lung	SQ1	9.8
Lung	SW1271	9.7
Lung	SW1573	10.1
Lung	SW900	9.6
Lung	VMRCLCD	10.3
Lung	VMRCLCP	10.2
Oesophagus	COLO680N	9.5
Oesophagus	ECGI10	10.1
Oesophagus	KYSE140	10.1
Oesophagus	KYSE150	9.9
Oesophagus	KYSE180	10.6
Oesophagus	KYSE270	10.2
Oesophagus	KYSE30	8.8
Oesophagus	KYSE410	10
Oesophagus	KYSE450	10.6
Oesophagus	KYSE510	9.8
Oesophagus	KYSE520	9.5
Oesophagus	KYSE70	10.2
Oesophagus	OE19	9.4
Oesophagus	OE33	9.9
Oesophagus	TE10	10
Oesophagus	TE11	10.2
Oesophagus	TE14	9.9
Oesophagus	TE15	9.8
Oesophagus	TE1	9.5
Oesophagus	TE4	9.2
Oesophagus	TE5	9.3
Oesophagus	TE6	10.2
Oesophagus	TE8	10.6
Oesophagus	TE9	9.8
Oesophagus	TT	10.1
Ovary	59M	8.5
Ovary	A2780	9.4
Ovary	CAOV3	9.7
Ovary	CAOV4	9.5
Ovary	COLO704	9.7
Ovary	COV318	9.4
Ovary	COV362	9.3
Ovary	COV434	9.4
Ovary	COV504	9.5
Ovary	COV644	10.1
Ovary	EFO21	10
Ovary	EFO27	8.4
Ovary	ES2	9.4
Ovary	FUOV1	9.3
Ovary	HEYA8	9.1
Ovary	HS571T	8.9
Ovary	IGROV1	9.1
Ovary	JHOC5	9.2
Ovary	JHOM1	10
Ovary	JHOM2B	9.8
Ovary	JHOS2	8.8
Ovary	JHOS4	9.9
Ovary	KURAMOCHI	9.6
Ovary	MCAS	10.7
Ovary	NIHOVCAR3	10.4
Ovary	OAW28	8.9
Ovary	OAW42	9.4
Ovary	OC314	9.6
Ovary	OC316	9.8
Ovary	ONCODG1	10.4
Ovary	OV56	9.9
Ovary	OV7	9.6
Ovary	OV90	9.2
Ovary	OVCAR4	10.3
Ovary	OVCAR8	9.9
Ovary	OVISE	9.3
Ovary	OVK18	9.4
Ovary	OVKATE	10.3
Ovary	OVMANA	9.6
Ovary	OVSAHO	10
Ovary	OVTOKO	9.8
Ovary	RMGI	9.3
Ovary	RMUGS	9.5
Ovary	SKOV3	9.3
Ovary	SNU119	9.8
Ovary	SNU840	9.4
Ovary	SNU8	9.6
Ovary	TOV112D	9
Ovary	TOV21G	8.8
Ovary	TYKNU	9.7
Pancreas	ASPC1	9.1
Pancreas	BXPC3	9.4
Pancreas	CAPAN1	9.4
Pancreas	CAPAN2	9.2
Pancreas	CFPAC1	9.4
Pancreas	DANG	10.1
Pancreas	HPAC	10
Pancreas	HPAFII	9.1
Pancreas	HS766T	9.2
Pancreas	HUPT3	9.4
Pancreas	HUPT4	9.5
Pancreas	KCIMOH1	9.2
Pancreas	KLM1	9.6
Pancreas	KP2	10.6
Pancreas	KP3	9
Pancreas	KP4	9.9
Pancreas	L33	9.9
Pancreas	MIAPACA2	10.2
Pancreas	PANC0203	9.8
Pancreas	PANC0213	10
Pancreas	PANC0327	10.1
Pancreas	PANC0403	9.3
Pancreas	PANC0504	9.1
Pancreas	PANC0813	9.8
Pancreas	PANC1005	9.5
Pancreas	PANC1	10.3
Pancreas	PATU8902	10
Pancreas	PATU8988S	9.6
Pancreas	PATU8988T	9.7
Pancreas	PK1	10
Pancreas	PK45H	9.7
Pancreas	PK59	8.8
Pancreas	PL45	9.8
Pancreas	PSN1	9.6
Pancreas	QGP1	10.2
Pancreas	SNU213	9.4
Pancreas	SNU324	10.1
Pancreas	SNU410	10.1
Pancreas	SU8686	9.8
Pancreas	SUIT2	9.6
Pancreas	SW1990	9.9
Pancreas	T3M4	9.7
Pancreas	TCCPAN2	9.4
Pancreas	YAPC	9.6
Pleura	ACCMESO1	9.8
Pleura	DM3	8.5
Pleura	ISTMES1	9.3
Pleura	ISTMES2	10.3
Pleura	JL1	9.1
Pleura	MPP89	9.7
Pleura	MSTO211H	9.8
Pleura	NCIH2052	8.8
Pleura	NCIH2452	10.2
Pleura	NCIH28	9.4
Prostate	22RV1	9.4
Prostate	DU145	9.6
Prostate	LNCAPCLONEFGC	9.7
Prostate	MDAPCA2B	8
Prostate	NCIH660	10.3
Prostate	PC3	8.6
Prostate	VCAP	9
Salivary gland	A253	9.3
Salivary gland	YD15	10.1
Skin	A101D	10
Skin	A2058	9.3
Skin	A375	9.7
Skin	C32	9.2
Skin	CHL1	8.8
Skin	CJM	10.2
Skin	COLO679	9.3
Skin	COLO741	9.9
Skin	COLO783	9.3
Skin	COLO792	8
Skin	COLO800	10.4
Skin	COLO818	10
Skin	COLO829	9.4
Skin	COLO849	9.7
Skin	G361	10
Skin	GRM	9.3
Skin	HMCB	9.5
Skin	HS294T	9.1
Skin	HS600T	9.6
Skin	HS688AT	9.5
Skin	HS695T	9.9
Skin	HS839T	9.7
Skin	HS852T	9.8
Skin	HS895T	9.4
Skin	HS934T	9.5
Skin	HS936T	9.5
Skin	HS939T	9.8
Skin	HS940T	9.2
Skin	HS944T	9.4
Skin	HT144	9.8
Skin	IGR1	9.3
Skin	IGR37	9.4
Skin	IGR39	9.7
Skin	IPC298	9.5
Skin	K029AX	9.5
Skin	LOXIMVI	9
Skin	MALME3M	9.8
Skin	MDAMB435S	10.3
Skin	MELHO	10.2
Skin	MELJUSO	10.1
Skin	MEWO	9.8
Skin	RPMI7951	10
Skin	RVH421	9.2
Skin	SH4	9.8
Skin	SKMEL1	9.4
Skin	SKMEL24	8.8
Skin	SKMEL28	10.1
Skin	SKMEL2	9.8
Skin	SKMEL30	9.7
Skin	SKMEL31	9.1
Skin	SKMEL3	9.4
Skin	SKMEL5	9.4
Skin	UACC257	9.1
Skin	UACC62	10.1
Skin	WM115	9
Skin	WM1799	9.5
Skin	WM2664	9.3
Skin	WM793	9
Skin	WM88	9.2
Skin	WM983B	9.9
Small intestine	HUTU80	9.5
Soft tissue	A204	9.6
Soft tissue	G401	9.5
Soft tissue	G402	9.7
Soft tissue	GCT	9.5
Soft tissue	HS729	9.9
Soft tissue	HT1080	9.6
Soft tissue	KYM1	9.4
Soft tissue	MESSA	9.3
Soft tissue	RD	9.4
Soft tissue	RH30	7.9
Soft tissue	RH41	8.8
Soft tissue	RKN	9.2
Soft tissue	S117	8.7
Soft tissue	SJRH30	9.3
Soft tissue	SKLMS1	9.7
Soft tissue	SKUT1	10.2
Soft tissue	TE125T	9.6
Soft tissue	TE159T	9.2
Soft tissue	TE441T	9.9
Soft tissue	TE617T	9.5
Stomach	2313287	10
Stomach	AGS	9.5
Stomach	AZ521	9.2
Stomach	ECC10	9.8
Stomach	ECC12	9.7
Stomach	FU97	9.4
Stomach	GCIY	9.6
Stomach	GSS	9.5
Stomach	GSU	10.6
Stomach	HGC27	9.4
Stomach	HS746T	9.6
Stomach	HUG1N	10.7
Stomach	IM95	9.7
Stomach	KATOIII	10
Stomach	KE39	10.1
Stomach	LMSU	9.7
Stomach	MKN1	9.6
Stomach	MKN45	9.6
Stomach	MKN74	9.8
Stomach	MKN7	8.9
Stomach	NCCSTCK140	9.2
Stomach	NCIN87	9.6
Stomach	NUGC2	9.7
Stomach	NUGC3	9.1
Stomach	NUGC4	9.8
Stomach	OCUM1	9.2
Stomach	RERFGC1B	9
Stomach	SH10TC	9.5
Stomach	SNU16	9.5
Stomach	SNU1	9.9
Stomach	SNU216	9.7
Stomach	SNU520	9.9
Stomach	SNU5	9.1
Stomach	SNU601	10
Stomach	SNU620	10.5
Stomach	SNU668	8.4
Stomach	SNU719	9.3
Stomach	TGBC11TKB	9.3
Thyroid	8305C	9.2
Thyroid	8505C	9.7
Thyroid	BCPAP	9.1
Thyroid	BHT101	9.7
Thyroid	CAL62	10.3
Thyroid	CGTHW1	9.9
Thyroid	FTC133	10
Thyroid	FTC238	9.4
Thyroid	ML1	9.6
Thyroid	SW579	9.7
Thyroid	TT2609C02	9.4
Thyroid	TT	9.1
Upper aerodigestive tract	BHY	9.5
Upper aerodigestive tract	BICR16	9.6
Upper aerodigestive tract	BICR18	9.8
Upper aerodigestive tract	BICR22	9.5
Upper aerodigestive tract	BICR31	9.6
Upper aerodigestive tract	BICR56	10.1
Upper aerodigestive tract	BICR6	9.1
Upper aerodigestive tract	CAL27	9.7
Upper aerodigestive tract	CAL33	10.1
Upper aerodigestive tract	DETROIT562	10
Upper aerodigestive tract	FADU	9.9
Upper aerodigestive tract	HS840T	9.2
Upper aerodigestive tract	HSC2	9.5
Upper aerodigestive tract	HSC3	9.7
Upper aerodigestive tract	HSC4	10.3
Upper aerodigestive tract	PECAPJ15	10
Upper aerodigestive tract	PECAPJ34CLONEC12	9.7
Upper aerodigestive tract	PECAPJ41CLONED2	9.3
Upper aerodigestive tract	PECAPJ49	10.3
Upper aerodigestive tract	SCC15	9.7
Upper aerodigestive tract	SCC25	9.3
Upper aerodigestive tract	SCC4	9.9
Upper aerodigestive tract	SCC9	9.6
Upper aerodigestive tract	SNU1076	9.5
Upper aerodigestive tract	SNU1214	10.3
Upper aerodigestive tract	SNU46	9.6
Upper aerodigestive tract	SNU899	9.3
Upper aerodigestive tract	YD10B	10.2
Upper aerodigestive tract	YD38	9.4
Upper aerodigestive tract	YD8	9.6
Urinary tract	5637	9.4
Urinary tract	639V	9.6
Urinary tract	647V	9.3
Urinary tract	BC3C	10.2
Urinary tract	BFTC905	9.1
Urinary tract	CAL29	10
Urinary tract	HS172T	9.3
Urinary tract	HT1197	9
Urinary tract	HT1376	10.1
Urinary tract	J82	9.8
Urinary tract	JMSU1	9.8
Urinary tract	KMBC2	10.1
Urinary tract	KU1919	9.5
Urinary tract	RT11284	10.1
Urinary tract	RT112	10.2
Urinary tract	RT4	9.1
Urinary tract	SCABER	10
Urinary tract	SW1710	9.3
Urinary tract	SW780	9.7
Urinary tract	T24	9.7
Urinary tract	TCCSUP	9.8
Urinary tract	UMUC1	9.1
Urinary tract	UMUC3	9.8
Urinary tract	VMCUB1	10.4

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	20
Adrenal gland	23.6
Appendix	45.8
Bone marrow	27.7
Breast	26.3
Cerebral cortex	26.1
Cervix, uterine	48.3
Colon	19
Duodenum	23.9
Endometrium	37.7
Epididymis	29.1
Esophagus	16
Fallopian tube	28.4
Gallbladder	33.1
Heart muscle	13
Kidney	21.9
Liver	19.1
Lung	32.5
Lymph node	77.5
Ovary	30.1
Pancreas	4.7
Parathyroid gland	31.8
Placenta	27.4
Prostate	29
Rectum	25.2
Salivary gland	8.5
Seminal vesicle	24.1
Skeletal muscle	8.8
Skin	27.5
Small intestine	25.1
Smooth muscle	28.1
Spleen	53.8
Stomach	25.8
Testis	31.5
Thyroid gland	31.6
Tonsil	68.3
Urinary bladder	24.9

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
19127118	Underexpression (hypermethylation)	Colon Carcinoma; Ovarian Carcinoma	The MED1 promoter region was sequenced following bisulfite treatment and sequence analysis identified a CpG island within the MED1 promoter which is frequently and preferentially methylated (> or =50%) in ovarian and colorectal cancer cell lines with low/reduced MED1 expression.
11230735	Underexpression	Hepatocellular Carcinoma	Reduced expression of DNA repair protein, MBD4, was significantly correlated with poorer tumor differentiation and involvement of portal vein. Slightly reduced expression of MBD2 was detected in HCCs, and the expression of MeCP2 was particularly reduced in HCCs with portal vein involvement. These data suggest that overexpression of DNMT1 and DNMT3a, DNA hypermethylation on CpG islands, and DNA hypomethylation on pericentromeric satellite regions are early events during hepatocarcinogenesis, and that reduced expression of MBD4 may play a role in malignant progression of HCC.

Summary
Symbol	MBD4
Name	methyl-CpG binding domain 4, DNA glycosylase
Aliases	methyl-CpG binding domain protein 4; 3,N(4)-ethenocytosine glycosylase; G/5-fluorouracil mismatch glycosylas ......
Location	3q21.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.576	4.08e-37	5.2	46.5	48.3	Gain
BRCA	Breast invasive carcinoma	1075	0.61	9.47e-111	10.9	67.1	22	Neutral
CESC	Cervical and endocervical cancers	292	0.795	4.92e-65	2.7	33.9	63.4	Gain
COAD	Colon adenocarcinoma	449	0.279	1.73e-09	7.3	78.2	14.5	Neutral
ESCA	Esophageal carcinoma	183	0.713	1.02e-29	10.9	36.6	52.5	Gain
GBM	Glioblastoma multiforme	147	0.371	3.84e-06	6.1	74.8	19	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.714	2.89e-81	4.3	39.3	56.4	Gain
KIRC	Kidney renal clear cell carcinoma	525	0.617	2.4e-56	19.6	67.6	12.8	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.553	1.73e-24	2.8	63.9	33.3	Neutral
LAML	Acute Myeloid Leukemia	166	0.259	0.000767	1.8	97.6	0.6	Neutral
LGG	Brain Lower Grade Glioma	513	0.316	2.27e-13	7.2	91	1.8	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.375	1.26e-13	11.3	76.6	12.1	Neutral
LUAD	Lung adenocarcinoma	512	0.668	1.66e-67	23.4	53.9	22.7	Neutral
LUSC	Lung squamous cell carcinoma	498	0.737	2.64e-86	6.2	22.3	71.5	Gain
OV	Ovarian serous cystadenocarcinoma	300	0.564	1.41e-26	7.3	34.3	58.3	Gain
PAAD	Pancreatic adenocarcinoma	177	0.324	1.1e-05	10.2	77.4	12.4	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.801	2.03e-37	56.8	43.2	0	Loss
PRAD	Prostate adenocarcinoma	491	0.692	2.45e-71	2.6	82.3	15.1	Neutral
READ	Rectum adenocarcinoma	164	0.231	0.00294	6.1	72.6	21.3	Neutral
SARC	Sarcoma	255	0.701	4.35e-39	19.2	65.1	15.7	Neutral
SKCM	Skin Cutaneous Melanoma	367	0.583	7.81e-35	16.3	64.6	19.1	Neutral
STAD	Stomach adenocarcinoma	413	0.49	2.81e-26	11.4	61.5	27.1	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.363	4.93e-06	16	60	24	Neutral
THCA	Thyroid carcinoma	497	0.077	0.0869	0.8	98.8	0.4	Neutral
THYM	Thymoma	119	0.382	1.84e-05	6.7	89.1	4.2	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.443	3.17e-27	3.5	74.9	21.6	Neutral

Summary
Symbol	MBD4
Name	methyl-CpG binding domain 4, DNA glycosylase
Aliases	methyl-CpG binding domain protein 4; 3,N(4)-ethenocytosine glycosylase; G/5-fluorouracil mismatch glycosylas ......
Location	3q21.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.274	1.03e-08	17	408	-0.003	0.294	NS/NA
BRCA	Breast invasive carcinoma	-0.194	8.24e-09	83	785	0	0.702	NS/NA
CESC	Cervical and endocervical cancers	-0.402	2.2e-13	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.273	9.38e-07	19	297	-0.002	0.943	NS/NA
ESCA	Esophageal carcinoma	-0.391	2.19e-08	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.278	0.0255	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.269	2.29e-10	20	522	-0.004	0.0565	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.27	4.38e-07	24	319	0.004	5.36e-06	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.183	0.00149	23	275	0	0.576	NS/NA
LAML	Acute Myeloid Leukemia	-0.267	0.000462	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.164	0.00015	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.112	0.0223	41	373	-0.002	0.414	NS/NA
LUAD	Lung adenocarcinoma	-0.151	0.000987	21	456	0.027	0.236	NS/NA
LUSC	Lung squamous cell carcinoma	-0.398	1.66e-16	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.75	0.0255	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.178	0.0162	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.521	0	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.131	0.00247	35	498	0.003	6.24e-06	NS/NA
READ	Rectum adenocarcinoma	-0.364	0.000201	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.409	7.04e-12	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.255	2.1e-08	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.152	0.00325	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.28	0.000425	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.118	0.0052	50	509	-0.001	0.213	NS/NA
THYM	Thymoma	-0.272	0.00248	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.211	4.75e-06	34	431	-0.006	0.00448	NS/NA

Summary
Symbol	MBD4
Name	methyl-CpG binding domain 4, DNA glycosylase
Aliases	methyl-CpG binding domain protein 4; 3,N(4)-ethenocytosine glycosylase; G/5-fluorouracil mismatch glycosylas ......
Location	3q21.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	1	Low
Appendix	1	Low
Bone marrow	2	Medium
Breast	2	Medium
Bronchus	2	Medium
Caudate	1	Low
Cerebellum	3	High
Cerebral cortex	2	Medium
Cervix, uterine	2	Medium
Colon	2	Medium
Duodenum	1	Low
Endometrium	2	Medium
Epididymis	1	Low
Esophagus	2	Medium
Fallopian tube	1	Low
Gallbladder	2	Medium
Heart muscle	0	Not detected
Hippocampus	1	Low
Kidney	1	Low
Liver	1	Low
Lung	2	Medium
Lymph node	3	High
Nasopharynx	2	Medium
Oral mucosa	2	Medium
Ovary	1	Low
Pancreas	1	Low
Parathyroid gland	0	Not detected
Placenta	2	Medium
Prostate	2	Medium
Rectum	2	Medium
Salivary gland	1	Low
Seminal vesicle	1	Low
Skeletal muscle	1	Low
Skin	3	High
Small intestine	1	Low
Smooth muscle	1	Low
Soft tissue	3	High
Spleen	1	Low
Stomach	1	Low
Testis	2	Medium
Thyroid gland	2	Medium
Tonsil	3	High
Urinary bladder	2	Medium
Vagina	2	Medium

Summary
Symbol	MBD4
Name	methyl-CpG binding domain 4, DNA glycosylase
Aliases	methyl-CpG binding domain protein 4; 3,N(4)-ethenocytosine glycosylase; G/5-fluorouracil mismatch glycosylas ......
Location	3q21.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.572	NS	24476821
BRCA	Breast invasive carcinoma	521	1.54e-05	Significant	23000897
COAD	Colon adenocarcinoma	149	0.0239	Significant	22810696
GBM	Glioblastoma multiforme	157	1.74e-05	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	4.74e-05	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.0214	Significant	26536169
LGG	Brain Lower Grade Glioma	513	4.78e-10	Significant	26824661
LUAD	Lung adenocarcinoma	230	0.000547	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	0.223	NS	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.000142	Significant	21720365
PRAD	Prostate adenocarcinoma	333	0.194	NS	26544944
READ	Rectum adenocarcinoma	67	0.196	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.703	NS	26091043
STAD	Stomach adenocarcinoma	277	1.57e-05	Significant	25079317
THCA	Thyroid carcinoma	391	1.6e-07	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	1.31e-06	Significant	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	0.849	0.428	NS
BRCA	Breast invasive carcinoma	1079	1.208	0.408	NS
CESC	Cervical and endocervical cancers	291	0.58	0.126	NS
COAD	Colon adenocarcinoma	439	0.94	0.824	NS
ESCA	Esophageal carcinoma	184	0.984	0.962	NS
GBM	Glioblastoma multiforme	158	1.209	0.468	NS
HNSC	Head and Neck squamous cell carcinoma	518	0.858	0.43	NS
KIRC	Kidney renal clear cell carcinoma	531	1.601	0.0282	Shorter
KIRP	Kidney renal papillary cell carcinoma	287	1.163	0.697	NS
LAML	Acute Myeloid Leukemia	149	0.935	0.814	NS
LGG	Brain Lower Grade Glioma	511	2.063	0.00287	Shorter
LIHC	Liver hepatocellular carcinoma	365	0.813	0.426	NS
LUAD	Lung adenocarcinoma	502	0.826	0.343	NS
LUSC	Lung squamous cell carcinoma	494	1.114	0.589	NS
OV	Ovarian serous cystadenocarcinoma	303	1.171	0.459	NS
PAAD	Pancreatic adenocarcinoma	177	1.326	0.319	NS
PCPG	Pheochromocytoma and Paraganglioma	179	0.936	0.947	NS
PRAD	Prostate adenocarcinoma	497	8.773	0.0187	Shorter
READ	Rectum adenocarcinoma	159	0.704	0.549	NS
SARC	Sarcoma	259	0.793	0.374	NS
SKCM	Skin Cutaneous Melanoma	459	0.353	1.67e-07	Longer
STAD	Stomach adenocarcinoma	388	0.806	0.341	NS
TGCT	Testicular Germ Cell Tumors	134	538963023.484	0.342	NS
THCA	Thyroid carcinoma	500	0.622	0.5	NS
THYM	Thymoma	119	0.52	0.587	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	1.244	0.445	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	0.037	0.457	NS
BRCA	Breast invasive carcinoma	1071	-0.006	0.852	NS
CESC	Cervical and endocervical cancers	167	0.011	0.886	NS
COAD	Colon adenocarcinoma	445	0.006	0.9	NS
ESCA	Esophageal carcinoma	162	0.129	0.102	NS
HNSC	Head and Neck squamous cell carcinoma	448	0.058	0.221	NS
KIRC	Kidney renal clear cell carcinoma	531	0.154	0.000378	Higher
KIRP	Kidney renal papillary cell carcinoma	260	-0.116	0.0622	NS
LIHC	Liver hepatocellular carcinoma	347	-0.105	0.0501	NS
LUAD	Lung adenocarcinoma	507	-0.074	0.0961	NS
LUSC	Lung squamous cell carcinoma	497	-0.096	0.0327	Lower
OV	Ovarian serous cystadenocarcinoma	302	0.065	0.26	NS
PAAD	Pancreatic adenocarcinoma	176	-0.029	0.698	NS
READ	Rectum adenocarcinoma	156	0.048	0.553	NS
SKCM	Skin Cutaneous Melanoma	410	-0.001	0.982	NS
STAD	Stomach adenocarcinoma	392	0.011	0.832	NS
TGCT	Testicular Germ Cell Tumors	81	-0.023	0.837	NS
THCA	Thyroid carcinoma	499	0.017	0.706	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.07	0.116	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	-0.02	0.747	NS
HNSC	Head and Neck squamous cell carcinoma	498	0.113	0.0119	Higher
KIRC	Kidney renal clear cell carcinoma	525	0.087	0.0474	Higher
LGG	Brain Lower Grade Glioma	514	0.159	0.000309	Higher
LIHC	Liver hepatocellular carcinoma	366	-0.147	0.00472	Lower
OV	Ovarian serous cystadenocarcinoma	296	0.182	0.00164	Higher
PAAD	Pancreatic adenocarcinoma	176	-0.12	0.114	NS
STAD	Stomach adenocarcinoma	406	-0.042	0.396	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.13	0.00254	Higher

Summary
Symbol	MBD4
Name	methyl-CpG binding domain 4, DNA glycosylase
Aliases	methyl-CpG binding domain protein 4; 3,N(4)-ethenocytosine glycosylase; G/5-fluorouracil mismatch glycosylas ......
Location	3q21.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	MBD4
Name	methyl-CpG binding domain 4, DNA glycosylase
Aliases	methyl-CpG binding domain protein 4; 3,N(4)-ethenocytosine glycosylase; G/5-fluorouracil mismatch glycosylas ......
Location	3q21.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for MBD4.

Summary
Symbol	MBD4
Name	methyl-CpG binding domain 4, DNA glycosylase
Aliases	methyl-CpG binding domain protein 4; 3,N(4)-ethenocytosine glycosylase; G/5-fluorouracil mismatch glycosylas ......
Location	3q21.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining [ TOP ]
There is no record for MBD4.