CR2Cancer

Summary
Symbol	MTA1
Name	metastasis associated 1
Aliases	metastasis associated gene 1 protein; Metastasis-associated protein MTA1
Location	14q32.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

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Domain

PF01426 BAH domain
PF01448 ELM2 domain
PF00320 GATA zinc finger
PF00249 Myb-like DNA-binding domain

Function

Transcriptional coregulator which can act as both a transcriptional corepressor and coactivator. As a part of the histone-deacetylase multiprotein complex (NuRD), regulates transcription of its targets by modifying the acetylation status of the target chromatin and cofactor accessibility to the target DNA. In conjunction with other components of NuRD, acts as a transcriptional corepressor of BRCA1, ESR1, TFF1 and CDKN1A. Acts as a transcriptional coactivator of BCAS3, PAX5 and SUMO2, independent of the NuRD complex. Stimulates the expression of WNT1 by inhibiting the expression of its transcriptional corepressor SIX3. Plays a role in the inflammatory responses, both as a target and as a component of the NF-kappa-B signaling and regulates a subset of proinflammatory cytokines such as IL1B, MIP2, and TNF. Regulates p53-dependent and -independent DNA repair processes following genotoxic stress. Regulates the stability and function of p53/TP53 by inhibiting its ubiquitination by COP1 and MDM2 thereby regulating the p53-dependent DNA repair. Plays an important role in tumorigenesis, tumor invasion, and metastasis. Involved in the epigenetic regulation of ESR1 expression in breast cancer in a TFAP2C, IFI16 and HDAC4/5/6-dependent manner. Plays a role in the regulation of the circadian clock and is essential for the generation and maintenance of circadian rhythms under constant light and for normal entrainment of behavior to light-dark (LD) cycles. Positively regulates the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of its own transcription and the transcription of CRY1. Regulates deacetylation of ARNTL/BMAL1 by regulating SIRT1 expression, resulting in derepressing CRY1-mediated transcription repression. Isoform Short binds to ESR1 and sequesters it in the cytoplasm and enhances its non-genomic responses.

Classification

Class	Modification	Substrate	Product	PubMed
Chromatin remodelling cofactor	#	#	#	9885572

> Gene Ontology [ TOP ]
Biological Process	GO:0002237 response to molecule of bacterial origin GO:0006302 double-strand break repair GO:0006476 protein deacetylation GO:0007622 rhythmic behavior GO:0007623 circadian rhythm GO:0007626 locomotory behavior GO:0009314 response to radiation GO:0009416 response to light stimulus GO:0009648 photoperiodism GO:0009649 entrainment of circadian clock GO:0010212 response to ionizing radiation GO:0010498 proteasomal protein catabolic process GO:0016570 histone modification GO:0016575 histone deacetylation GO:0016925 protein sumoylation GO:0018205 peptidyl-lysine modification GO:0031396 regulation of protein ubiquitination GO:0031398 positive regulation of protein ubiquitination GO:0032496 response to lipopolysaccharide GO:0032922 circadian regulation of gene expression GO:0035601 protein deacylation GO:0040029 regulation of gene expression, epigenetic GO:0042752 regulation of circadian rhythm GO:0043153 entrainment of circadian clock by photoperiod GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0045475 locomotor rhythm GO:0048511 rhythmic process GO:0048512 circadian behavior GO:0050727 regulation of inflammatory response GO:0051865 protein autoubiquitination GO:0098732 macromolecule deacylation GO:1902498 regulation of protein autoubiquitination GO:1902499 positive regulation of protein autoubiquitination GO:1903320 regulation of protein modification by small protein conjugation or removal GO:1903322 positive regulation of protein modification by small protein conjugation or removal
Molecular Function	GO:0001046 core promoter sequence-specific DNA binding GO:0001047 core promoter binding GO:0001085 RNA polymerase II transcription factor binding GO:0001103 RNA polymerase II repressing transcription factor binding GO:0003682 chromatin binding GO:0003713 transcription coactivator activity GO:0003714 transcription corepressor activity GO:0004407 histone deacetylase activity GO:0008134 transcription factor binding GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides GO:0019213 deacetylase activity GO:0033558 protein deacetylase activity GO:0070491 repressing transcription factor binding
Cellular Component	GO:0005635 nuclear envelope GO:0005874 microtubule

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-427389: ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-212165: Epigenetic regulation of gene expression R-HSA-74160: Gene Expression R-HSA-3214815: HDACs deacetylate histones R-HSA-392499: Metabolism of proteins R-HSA-5250913: Positive epigenetic regulation of rRNA expression R-HSA-597592: Post-translational protein modification R-HSA-73854: RNA Polymerase I Promoter Clearance R-HSA-73864: RNA Polymerase I Transcription R-HSA-73762: RNA Polymerase I Transcription Initiation R-HSA-504046: RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription R-HSA-3108232: SUMO E3 ligases SUMOylate target proteins R-HSA-2990846: SUMOylation R-HSA-3232118: SUMOylation of transcription factors

> KEGG and Reactome Pathway

[ TOP ]

KEGG

Reactome

R-HSA-3247509: Chromatin modifying enzymes
R-HSA-4839726: Chromatin organization
R-HSA-427389: ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
R-HSA-212165: Epigenetic regulation of gene expression
R-HSA-74160: Gene Expression
R-HSA-3214815: HDACs deacetylate histones
R-HSA-392499: Metabolism of proteins
R-HSA-5250913: Positive epigenetic regulation of rRNA expression
R-HSA-597592: Post-translational protein modification
R-HSA-73854: RNA Polymerase I Promoter Clearance
R-HSA-73864: RNA Polymerase I Transcription
R-HSA-73762: RNA Polymerase I Transcription Initiation
R-HSA-504046: RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
R-HSA-3108232: SUMO E3 ligases SUMOylate target proteins
R-HSA-2990846: SUMOylation
R-HSA-3232118: SUMOylation of transcription factors

Summary
Symbol	MTA1
Name	metastasis associated 1
Aliases	metastasis associated gene 1 protein; Metastasis-associated protein MTA1
Location	14q32.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM4798751	c.1713C>T	p.V571V	Substitution - coding silent	Liver
COSM953996	c.33C>T	p.Y11Y	Substitution - coding silent	Large_intestine
COSM5956226	c.653+3G>A	p.?	Unknown	Upper_aerodigestive_tract
COSM1368704	c.1243C>T	p.R415C	Substitution - Missense	Skin
COSM2027706	c.1907delG	p.G638fs*11	Deletion - Frameshift	Large_intestine
COSM1188930	c.1271G>T	p.W424L	Substitution - Missense	Lung
COSM4795027	c.631G>A	p.D211N	Substitution - Missense	Liver
COSM469729	c.1182G>C	p.E394D	Substitution - Missense	Kidney
COSM1258018	c.1944G>A	p.M648I	Substitution - Missense	Oesophagus
COSM5350170	c.1807A>T	p.S603C	Substitution - Missense	Lung
COSM4620678	c.1591C>T	p.R531C	Substitution - Missense	Large_intestine
COSM287290	c.113_114insG	p.E39fs*32	Insertion - Frameshift	Large_intestine
COSM4049558	c.1163G>A	p.G388E	Substitution - Missense	Stomach
COSM953996	c.33C>T	p.Y11Y	Substitution - coding silent	Endometrium
COSM5983405	c.1856G>A	p.R619Q	Substitution - Missense	Upper_aerodigestive_tract
COSM954001	c.1000G>A	p.D334N	Substitution - Missense	Endometrium
COSM3494290	c.775C>T	p.H259Y	Substitution - Missense	Skin
COSM3731914	c.1344+5delG	p.?	Unknown	Large_intestine
COSM2027689	c.1245T>C	p.R415R	Substitution - coding silent	Pancreas
COSM404545	c.1956C>T	p.D652D	Substitution - coding silent	Lung
COSM1607438	c.427C>T	p.R143W	Substitution - Missense	Liver
COSM4703488	c.2065G>A	p.A689T	Substitution - Missense	Large_intestine
COSM4703483	c.282C>T	p.D94D	Substitution - coding silent	Large_intestine
COSM4049568	c.2071C>T	p.R691C	Substitution - Missense	Stomach
COSM147860	c.1114G>A	p.V372I	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3983138	c.780G>A	p.K260K	Substitution - coding silent	Ovary
COSM4703486	c.1459C>T	p.R487C	Substitution - Missense	Large_intestine
COSM147860	c.1114G>A	p.V372I	Substitution - Missense	Large_intestine
COSM953998	c.602C>T	p.A201V	Substitution - Missense	Endometrium
COSM5814189	c.1742G>T	p.G581V	Substitution - Missense	Liver
COSM953997	c.34G>A	p.V12I	Substitution - Missense	Endometrium
COSM953997	c.34G>A	p.V12I	Substitution - Missense	Large_intestine
COSM4620678	c.1591C>T	p.R531C	Substitution - Missense	Large_intestine
COSM1215635	c.1607C>T	p.A536V	Substitution - Missense	Large_intestine
COSM1678293	c.909T>A	p.Y303*	Substitution - Nonsense	Haematopoietic_and_lymphoid_tissue
COSM953997	c.34G>A	p.V12I	Substitution - Missense	Large_intestine
COSM953996	c.33C>T	p.Y11Y	Substitution - coding silent	Large_intestine
COSM5097156	c.1146G>A	p.A382A	Substitution - coding silent	Large_intestine
COSM953998	c.602C>T	p.A201V	Substitution - Missense	Large_intestine
COSM954000	c.978C>A	p.Y326*	Substitution - Nonsense	Endometrium
COSM1368700	c.701G>A	p.R234Q	Substitution - Missense	Large_intestine
COSM4836525	c.359C>T	p.T120M	Substitution - Missense	Cervix
COSM5136501	c.1998-7C>T	p.?	Unknown	Large_intestine
COSM1607437	c.133T>C	p.F45L	Substitution - Missense	Liver
COSM1215634	c.212C>T	p.A71V	Substitution - Missense	Large_intestine
COSM5362372	c.1777+9delC	p.?	Unknown	Large_intestine
COSM1368703	c.1139C>T	p.T380M	Substitution - Missense	Large_intestine
COSM4798751	c.1713C>T	p.V571V	Substitution - coding silent	Liver
COSM5004724	c.1939C>T	p.R647W	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4049570	c.2124C>T	p.D708D	Substitution - coding silent	Stomach
COSM302683	c.1850C>A	p.P617Q	Substitution - Missense	Central_nervous_system
COSM2027701	c.1517C>T	p.A506V	Substitution - Missense	Small_intestine
COSM3689994	c.2116G>A	p.V706I	Substitution - Missense	Large_intestine
COSM1194420	c.1123G>T	p.G375C	Substitution - Missense	Lung
COSM40346	c.1105G>A	p.V369I	Substitution - Missense	Central_nervous_system
COSM953999	c.630C>T	p.I210I	Substitution - coding silent	Endometrium
COSM5447097	c.789C>T	p.Y263Y	Substitution - coding silent	Large_intestine
COSM5187156	c.905A>G	p.K302R	Substitution - Missense	Large_intestine
COSM1368701	c.723C>T	p.S241S	Substitution - coding silent	Large_intestine
COSM5161103	c.369-5T>C	p.?	Unknown	Large_intestine
COSM357514	c.772C>T	p.L258F	Substitution - Missense	Lung
COSM1662868	c.268C>A	p.P90T	Substitution - Missense	Kidney
COSM356781	c.1315G>C	p.E439Q	Substitution - Missense	Lung
COSM5122937	c.849C>T	p.D283D	Substitution - coding silent	Large_intestine
COSM4147934	c.1593C>A	p.R531R	Substitution - coding silent	Thyroid
COSM5562829	c.2089C>T	p.P697S	Substitution - Missense	Prostate
COSM6001234	c.810G>A	p.S270S	Substitution - coding silent	Prostate
COSM4703484	c.1453C>A	p.L485M	Substitution - Missense	Large_intestine
COSM1707921	c.1706C>T	p.A569V	Substitution - Missense	Skin
COSM5757820	c.1777+8_1777+9insC	p.?	Unknown	Bone
COSM379053	c.112G>A	p.V38M	Substitution - Missense	Lung
COSM1578180	c.1259G>C	p.C420S	Substitution - Missense	Lung
COSM954002	c.1252G>A	p.A418T	Substitution - Missense	Endometrium
COSM3494292	c.1905C>T	p.I635I	Substitution - coding silent	Skin
COSM4876361	c.2047C>T	p.R683W	Substitution - Missense	Prostate
COSM5808474	c.178G>T	p.D60Y	Substitution - Missense	Liver
COSM1368706	c.1972T>C	p.F658L	Substitution - Missense	Large_intestine
COSM3786224	c.908A>G	p.Y303C	Substitution - Missense	Pancreas
COSM4049559	c.1447C>T	p.R483W	Substitution - Missense	Stomach
COSM2027705	c.1906_1907insG	p.S639fs*18	Insertion - Frameshift	Large_intestine
COSM4049557	c.909T>C	p.Y303Y	Substitution - coding silent	Stomach
COSM2027676	c.1017+8C>T	p.?	Unknown	Large_intestine
COSM3689993	c.232G>A	p.G78S	Substitution - Missense	Large_intestine
COSM3793533	c.874G>C	p.E292Q	Substitution - Missense	Urinary_tract
COSM5187157	c.1123G>A	p.G375S	Substitution - Missense	Large_intestine
COSM1215637	c.403G>A	p.E135K	Substitution - Missense	Large_intestine
COSM4049563	c.1835C>T	p.A612V	Substitution - Missense	Stomach
COSM1721292	c.1637_1638insC	p.K549fs*3	Insertion - Frameshift	Large_intestine
COSM1607439	c.730G>C	p.A244P	Substitution - Missense	Liver
COSM5669017	c.361C>T	p.H121Y	Substitution - Missense	Soft_tissue
COSM3419674	c.1134C>T	p.N378N	Substitution - coding silent	Large_intestine
COSM3494296	c.2139C>T	p.I713I	Substitution - coding silent	Skin
COSM4426686	c.1937G>A	p.R646Q	Substitution - Missense	Oesophagus
COSM1300447	c.1691C>T	p.T564M	Substitution - Missense	Urinary_tract
COSM5718244	c.536A>C	p.D179A	Substitution - Missense	Skin
COSM1215633	c.1898G>A	p.R633H	Substitution - Missense	Large_intestine
COSM4703490	c.2113C>T	p.P705S	Substitution - Missense	Large_intestine
COSM953999	c.630C>T	p.I210I	Substitution - coding silent	Large_intestine
COSM953997	c.34G>A	p.V12I	Substitution - Missense	Large_intestine
COSM4608173	c.1444G>T	p.A482S	Substitution - Missense	Adrenal_gland
COSM1368702	c.888C>T	p.F296F	Substitution - coding silent	Large_intestine
COSM1368702	c.888C>T	p.F296F	Substitution - coding silent	Skin
COSM147860	c.1114G>A	p.V372I	Substitution - Missense	Stomach
COSM5740244	c.977A>G	p.Y326C	Substitution - Missense	Small_intestine
COSM1322763	c.1193C>T	p.T398I	Substitution - Missense	Ovary
COSM3731914	c.1344+5delG	p.?	Unknown	Large_intestine
COSM954001	c.1000G>A	p.D334N	Substitution - Missense	Large_intestine
COSM4627241	c.1487C>T	p.A496V	Substitution - Missense	Large_intestine
COSM3494291	c.956C>T	p.S319L	Substitution - Missense	Skin
COSM4759833	c.2044C>T	p.R682C	Substitution - Missense	Stomach
COSM5462360	c.352C>T	p.P118S	Substitution - Missense	Large_intestine
COSM1721292	c.1637_1638insC	p.K549fs*3	Insertion - Frameshift	Skin
COSM3731914	c.1344+5delG	p.?	Unknown	Large_intestine
COSM5547758	c.1140delG	p.A382fs*49	Deletion - Frameshift	Prostate
COSM1368705	c.1828G>A	p.G610R	Substitution - Missense	Large_intestine
COSM5687422	c.1127T>C	p.V376A	Substitution - Missense	Soft_tissue
COSM2027712	c.2005C>T	p.R669C	Substitution - Missense	Stomach
COSM312960	c.603G>A	p.A201A	Substitution - coding silent	Lung
COSM6015647	c.1076+7G>T	p.?	Unknown	Skin
COSM4049561	c.1464G>T	p.E488D	Substitution - Missense	Stomach
COSM1607438	c.427C>T	p.R143W	Substitution - Missense	Liver
COSM4703486	c.1459C>T	p.R487C	Substitution - Missense	Large_intestine
COSM4049566	c.2038G>A	p.A680T	Substitution - Missense	Stomach
COSM1721292	c.1637_1638insC	p.K549fs*3	Insertion - Frameshift	Large_intestine
COSM954004	c.1804C>T	p.P602S	Substitution - Missense	Endometrium
COSM4608509	c.1229C>A	p.P410H	Substitution - Missense	Adrenal_gland
COSM3731914	c.1344+5delG	p.?	Unknown	Large_intestine
COSM3786225	c.1917C>T	p.S639S	Substitution - coding silent	Pancreas
COSM5951202	c.1696G>T	p.A566S	Substitution - Missense	Oesophagus
COSM2027678	c.1033G>A	p.A345T	Substitution - Missense	Large_intestine
COSM5148407	c.1457G>A	p.C486Y	Substitution - Missense	Large_intestine
COSM1322764	c.1069C>G	p.P357A	Substitution - Missense	Ovary
COSM697770	c.36C>G	p.V12V	Substitution - coding silent	Lung
COSM953997	c.34G>A	p.V12I	Substitution - Missense	Large_intestine
COSM1215636	c.2143G>T	p.D715Y	Substitution - Missense	Large_intestine
COSM5763417	c.1244G>A	p.R415H	Substitution - Missense	Large_intestine
COSM1300448	c.2034G>C	p.K678N	Substitution - Missense	Urinary_tract
COSM147860	c.1114G>A	p.V372I	Substitution - Missense	Skin
COSM4502601	c.617C>A	p.T206K	Substitution - Missense	Skin
COSM5550300	c.187G>A	p.A63T	Substitution - Missense	Prostate
COSM3494294	c.2001G>A	p.K667K	Substitution - coding silent	Skin
COSM5180839	c.1722C>T	p.N574N	Substitution - coding silent	Large_intestine
COSM3731914	c.1344+5delG	p.?	Unknown	Large_intestine
COSM954003	c.1353C>A	p.H451Q	Substitution - Missense	Endometrium
COSM4930261	c.1382C>G	p.P461R	Substitution - Missense	Liver
COSM697769	c.883C>A	p.L295I	Substitution - Missense	Lung
COSM4599261	c.302A>C	p.H101P	Substitution - Missense	Upper_aerodigestive_tract
COSM5516688	c.48_50delCTC	p.S19delS	Deletion - In frame	Biliary_tract
COSM3401176	c.1936C>T	p.R646W	Substitution - Missense	Central_nervous_system
COSM3786225	c.1917C>T	p.S639S	Substitution - coding silent	Skin
COSM5519292	c.231C>T	p.N77N	Substitution - coding silent	Biliary_tract
COSM2027706	c.1907delG	p.G638fs*11	Deletion - Frameshift	Large_intestine
COSM1607439	c.730G>C	p.A244P	Substitution - Missense	Liver
COSM5626066	c.1899C>T	p.R633R	Substitution - coding silent	Oesophagus
COSM5381974	c.311G>A	p.R104Q	Substitution - Missense	Skin
COSM5153826	c.1344+4_1344+5insG	p.?	Unknown	Large_intestine
COSM5633044	c.973G>C	p.E325Q	Substitution - Missense	Oesophagus
COSM5916361	c.242-3C>T	p.?	Unknown	Skin
COSM2027705	c.1906_1907insG	p.S639fs*18	Insertion - Frameshift	Large_intestine
COSM6001464	c.1193-5C>T	p.?	Unknown	Prostate
COSM4147936	c.1834G>A	p.A612T	Substitution - Missense	Thyroid
COSM4637317	c.689G>A	p.S230N	Substitution - Missense	Large_intestine
COSM4605718	c.639C>T	p.F213F	Substitution - coding silent	Upper_aerodigestive_tract
COSM3885737	c.2122G>A	p.D708N	Substitution - Missense	Skin
COSM3731914	c.1344+5delG	p.?	Unknown	Stomach
COSM3955837	c.676G>T	p.A226S	Substitution - Missense	Lung
COSM2027706	c.1907delG	p.G638fs*11	Deletion - Frameshift	Large_intestine
COSM4891471	c.1169G>A	p.G390D	Substitution - Missense	Upper_aerodigestive_tract
COSM4795027	c.631G>A	p.D211N	Substitution - Missense	Liver
COSM1368704	c.1243C>T	p.R415C	Substitution - Missense	Large_intestine
COSM5740243	c.391C>T	p.L131F	Substitution - Missense	Small_intestine
COSM3731914	c.1344+5delG	p.?	Unknown	Large_intestine
COSM5422991	c.1925C>T	p.P642L	Substitution - Missense	Prostate
COSM357514	c.772C>T	p.L258F	Substitution - Missense	Pancreas
COSM50405	c.1427C>T	p.T476M	Substitution - Missense	Breast
COSM5186602	c.1727delC	p.T578fs*18	Deletion - Frameshift	Large_intestine
COSM1707920	c.1246C>T	p.L416F	Substitution - Missense	Skin
COSM1721292	c.1637_1638insC	p.K549fs*3	Insertion - Frameshift	Large_intestine
COSM1607437	c.133T>C	p.F45L	Substitution - Missense	Liver
COSM1607437	c.133T>C	p.F45L	Substitution - Missense	Liver
COSM391270	c.225delG	p.D76fs*8	Deletion - Frameshift	Lung

> Text Mining based Variations [ TOP ]
There is no record for MTA1.

Summary
Symbol	MTA1
Name	metastasis associated 1
Aliases	metastasis associated gene 1 protein; Metastasis-associated protein MTA1
Location	14q32.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

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Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
Q13330	446	S	Phosphoserine	-	No	None detected
Q13330	449	S	Phosphoserine	-	No	None detected
Q13330	522	S	Phosphoserine	-	No	None detected
Q13330	564	T	Phosphothreonine	-	Yes	p.T564M (cancer: BLCA)
Q13330	576	S	Phosphoserine	-	No	None detected
Q13330	578	T	Phosphothreonine	-	No	None detected
Q13330	626	K	N6-acetyllysine	-	No	None detected
Q13330	639	S	Phosphoserine	-	No	None detected

Summary
Symbol	MTA1
Name	metastasis associated 1
Aliases	metastasis associated gene 1 protein; Metastasis-associated protein MTA1
Location	14q32.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

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Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	5.69	6.074	0.36	0.00988	NS
BRCA	Breast invasive carcinoma	112	1100	5.526	5.734	0.258	1.87e-05	NS
CESC	Cervical and endocervical cancers	3	306	5.919	5.979	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	5.255	5.824	0.623	1.7e-12	Over
ESCA	Esophageal carcinoma	11	185	6.035	6.374	0.383	0.0647	NS
GBM	Glioblastoma multiforme	5	166	5.922	5.859	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	5.11	5.57	0.474	2.71e-07	NS
KIRC	Kidney renal clear cell carcinoma	72	534	4.46	5.05	0.578	1.97e-13	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	4.956	5.409	0.406	6.89e-05	NS
LAML	Acute Myeloid Leukemia	0	173	NA	6.799	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	6.387	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	4.454	4.636	0.243	0.00291	NS
LUAD	Lung adenocarcinoma	59	517	5.106	5.608	0.586	2.56e-11	Over
LUSC	Lung squamous cell carcinoma	51	501	5.047	5.972	0.989	2.46e-22	Over
OV	Ovarian serous cystadenocarcinoma	0	307	NA	6.901	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	5.671	5.614	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	5.357	6.178	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	5.67	5.965	0.244	0.000123	NS
READ	Rectum adenocarcinoma	10	167	5.117	5.807	0.76	0.000278	Over
SARC	Sarcoma	2	263	5.252	5.771	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	5.452	5.883	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	5.948	6.097	0.144	0.155	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	6.184	NA	NA	NA
THCA	Thyroid carcinoma	59	509	5.648	5.827	0.162	0.000918	NS
THYM	Thymoma	2	120	6.67	6.591	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	6.459	6.71	0.288	0.00299	NS

> Cancer Cell Line Encyclopedia (CCLE)

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Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	8.8
Autonomic ganglia	CHP212	7.4
Autonomic ganglia	IMR32	8.1
Autonomic ganglia	KELLY	6.5
Autonomic ganglia	KPNRTBM1	8.3
Autonomic ganglia	KPNSI9S	7.1
Autonomic ganglia	KPNYN	8.1
Autonomic ganglia	MHHNB11	9.5
Autonomic ganglia	NB1	7.3
Autonomic ganglia	NH6	7.4
Autonomic ganglia	SHSY5Y	8.8
Autonomic ganglia	SIMA	9.1
Autonomic ganglia	SKNAS	7.3
Autonomic ganglia	SKNBE2	7.9
Autonomic ganglia	SKNDZ	6.5
Autonomic ganglia	SKNFI	6.7
Autonomic ganglia	SKNSH	6.8
Biliary tract	HUCCT1	7.8
Biliary tract	HUH28	6.2
Biliary tract	SNU1079	8.4
Biliary tract	SNU1196	7.9
Biliary tract	SNU245	7.3
Biliary tract	SNU308	7.6
Biliary tract	SNU478	7.4
Bone	143B	8.4
Bone	A673	7.3
Bone	CADOES1	8.2
Bone	CAL78	7.2
Bone	G292CLONEA141B1	7
Bone	HOS	7.8
Bone	HS706T	6.1
Bone	HS737T	6.5
Bone	HS819T	6.5
Bone	HS821T	6.5
Bone	HS822T	6.4
Bone	HS863T	6.6
Bone	HS870T	6.2
Bone	HS888T	7
Bone	MG63	7.1
Bone	MHHES1	8.1
Bone	OUMS27	6.4
Bone	RDES	7.4
Bone	SJSA1	6.3
Bone	SKES1	7.5
Bone	SKNMC	7.9
Bone	SW1353	6.8
Bone	T173	6.1
Bone	TC71	7.7
Bone	U2OS	6.6
Breast	AU565	8.4
Breast	BT20	7.3
Breast	BT474	7.8
Breast	BT483	9
Breast	BT549	7.1
Breast	CAL120	7.7
Breast	CAL148	8
Breast	CAL51	7.9
Breast	CAL851	6.6
Breast	CAMA1	6.9
Breast	DU4475	7.2
Breast	EFM192A	7.7
Breast	EFM19	7.2
Breast	EVSAT	7.2
Breast	HCC1143	8.4
Breast	HCC1187	8.2
Breast	HCC1395	6.9
Breast	HCC1419	8.5
Breast	HCC1428	8.3
Breast	HCC1500	7.1
Breast	HCC1569	6.7
Breast	HCC1599	7.5
Breast	HCC1806	7.4
Breast	HCC1937	6.8
Breast	HCC1954	6.7
Breast	HCC202	8.7
Breast	HCC2157	6.9
Breast	HCC2218	6.8
Breast	HCC38	7
Breast	HCC70	7.7
Breast	HDQP1	7.2
Breast	HMC18	7.6
Breast	HS274T	6.8
Breast	HS281T	6.6
Breast	HS343T	6.9
Breast	HS578T	7
Breast	HS606T	6.5
Breast	HS739T	6.5
Breast	HS742T	6.4
Breast	JIMT1	6
Breast	KPL1	8.2
Breast	MCF7	7.3
Breast	MDAMB134VI	7.5
Breast	MDAMB157	7.6
Breast	MDAMB175VII	6.9
Breast	MDAMB231	6.7
Breast	MDAMB361	7.5
Breast	MDAMB415	6.4
Breast	MDAMB436	6.5
Breast	MDAMB453	7.8
Breast	MDAMB468	7.2
Breast	SKBR3	8.2
Breast	T47D	6.8
Breast	UACC812	7.7
Breast	UACC893	8.6
Breast	YMB1	8.3
Breast	ZR751	8.2
Breast	ZR7530	8.4
Central nervous system	1321N1	7.3
Central nervous system	42MGBA	6.7
Central nervous system	8MGBA	6.4
Central nervous system	A172	6.4
Central nervous system	AM38	7.3
Central nervous system	BECKER	6.6
Central nervous system	CAS1	6.7
Central nervous system	CCFSTTG1	7.1
Central nervous system	D283MED	8.1
Central nervous system	D341MED	8.2
Central nervous system	DAOY	7.6
Central nervous system	DBTRG05MG	6.6
Central nervous system	DKMG	7.1
Central nervous system	GAMG	6.4
Central nervous system	GB1	6.1
Central nervous system	GI1	7.2
Central nervous system	GMS10	6.6
Central nervous system	GOS3	6
Central nervous system	H4	7.2
Central nervous system	HS683	6.6
Central nervous system	KALS1	6.6
Central nervous system	KG1C	5.7
Central nervous system	KNS42	6.8
Central nervous system	KNS60	7.1
Central nervous system	KNS81	5.9
Central nervous system	KS1	6.7
Central nervous system	LN18	7.7
Central nervous system	LN229	6.3
Central nervous system	M059K	7.1
Central nervous system	MOGGCCM	6.1
Central nervous system	MOGGUVW	6.5
Central nervous system	NMCG1	7.1
Central nervous system	ONS76	7.2
Central nervous system	SF126	6.7
Central nervous system	SF295	7
Central nervous system	SNB19	6.4
Central nervous system	SNU1105	6.7
Central nervous system	SNU201	6
Central nervous system	SNU466	6.9
Central nervous system	SNU489	6.6
Central nervous system	SNU626	6.2
Central nervous system	SNU738	7.2
Central nervous system	SW1088	6.6
Central nervous system	SW1783	6.7
Central nervous system	T98G	6.5
Central nervous system	TM31	8.1
Central nervous system	U118MG	7.1
Central nervous system	U138MG	7
Central nervous system	U251MG	6.6
Central nervous system	U87MG	7.1
Central nervous system	YH13	7.1
Central nervous system	YKG1	6.3
Endometrium	AN3CA	7.6
Endometrium	COLO684	9.1
Endometrium	EFE184	7.2
Endometrium	EN	6.8
Endometrium	ESS1	6.7
Endometrium	HEC108	7.2
Endometrium	HEC151	7.2
Endometrium	HEC1A	7
Endometrium	HEC1B	7.5
Endometrium	HEC251	6.9
Endometrium	HEC265	7.2
Endometrium	HEC50B	7.1
Endometrium	HEC59	7.5
Endometrium	HEC6	7.1
Endometrium	ISHIKAWAHERAKLIO02ER	7.9
Endometrium	JHUEM1	7.4
Endometrium	JHUEM2	7.2
Endometrium	JHUEM3	7.3
Endometrium	KLE	7.9
Endometrium	MFE280	7.8
Endometrium	MFE296	7.9
Endometrium	MFE319	6.6
Endometrium	RL952	7.6
Endometrium	SNGM	7.9
Endometrium	SNU1077	8.2
Endometrium	SNU685	8.6
Endometrium	TEN	6.8
Haematopoietic and lymphoid	697	8.6
Haematopoietic and lymphoid	A3KAW	7.6
Haematopoietic and lymphoid	A4FUK	7.4
Haematopoietic and lymphoid	ALLSIL	8.2
Haematopoietic and lymphoid	AML193	7.3
Haematopoietic and lymphoid	AMO1	7.7
Haematopoietic and lymphoid	BCP1	7.3
Haematopoietic and lymphoid	BDCM	7
Haematopoietic and lymphoid	BL41	8.5
Haematopoietic and lymphoid	BL70	8.3
Haematopoietic and lymphoid	BV173	8.5
Haematopoietic and lymphoid	CA46	7.9
Haematopoietic and lymphoid	CI1	7.8
Haematopoietic and lymphoid	CMK115	7.1
Haematopoietic and lymphoid	CMK86	8.5
Haematopoietic and lymphoid	CMK	7.6
Haematopoietic and lymphoid	CMLT1	7.8
Haematopoietic and lymphoid	COLO775	7.5
Haematopoietic and lymphoid	DAUDI	8.1
Haematopoietic and lymphoid	DB	8.1
Haematopoietic and lymphoid	DEL	7.5
Haematopoietic and lymphoid	DND41	8.2
Haematopoietic and lymphoid	DOHH2	8.2
Haematopoietic and lymphoid	EB1	8
Haematopoietic and lymphoid	EB2	8.1
Haematopoietic and lymphoid	EHEB	7.3
Haematopoietic and lymphoid	EJM	7.3
Haematopoietic and lymphoid	EM2	7.2
Haematopoietic and lymphoid	EOL1	7.8
Haematopoietic and lymphoid	F36P	8.4
Haematopoietic and lymphoid	GA10	8.3
Haematopoietic and lymphoid	GDM1	7.7
Haematopoietic and lymphoid	GRANTA519	7.9
Haematopoietic and lymphoid	HDLM2	7.1
Haematopoietic and lymphoid	HDMYZ	6.9
Haematopoietic and lymphoid	HEL9217	7.3
Haematopoietic and lymphoid	HEL	7.8
Haematopoietic and lymphoid	HH	8.1
Haematopoietic and lymphoid	HL60	8.3
Haematopoietic and lymphoid	HPBALL	8
Haematopoietic and lymphoid	HS604T	6.3
Haematopoietic and lymphoid	HS611T	7.1
Haematopoietic and lymphoid	HS616T	6.8
Haematopoietic and lymphoid	HS751T	6.5
Haematopoietic and lymphoid	HT	7.4
Haematopoietic and lymphoid	HTK	8.8
Haematopoietic and lymphoid	HUNS1	7.4
Haematopoietic and lymphoid	HUT102	6.7
Haematopoietic and lymphoid	HUT78	7.2
Haematopoietic and lymphoid	JEKO1	8.7
Haematopoietic and lymphoid	JK1	7.7
Haematopoietic and lymphoid	JM1	7.5
Haematopoietic and lymphoid	JURKAT	8
Haematopoietic and lymphoid	JURLMK1	7.6
Haematopoietic and lymphoid	JVM2	7.5
Haematopoietic and lymphoid	JVM3	7.7
Haematopoietic and lymphoid	K562	7.1
Haematopoietic and lymphoid	KARPAS299	7.6
Haematopoietic and lymphoid	KARPAS422	8.2
Haematopoietic and lymphoid	KARPAS620	8.8
Haematopoietic and lymphoid	KASUMI1	8.2
Haematopoietic and lymphoid	KASUMI2	8.2
Haematopoietic and lymphoid	KASUMI6	8.2
Haematopoietic and lymphoid	KCL22	8.4
Haematopoietic and lymphoid	KE37	7.7
Haematopoietic and lymphoid	KE97	7.2
Haematopoietic and lymphoid	KG1	7.7
Haematopoietic and lymphoid	KHM1B	6.8
Haematopoietic and lymphoid	KIJK	7.2
Haematopoietic and lymphoid	KMH2	9
Haematopoietic and lymphoid	KMM1	7.8
Haematopoietic and lymphoid	KMS11	7.2
Haematopoietic and lymphoid	KMS12BM	9.2
Haematopoietic and lymphoid	KMS18	8.2
Haematopoietic and lymphoid	KMS20	7.4
Haematopoietic and lymphoid	KMS21BM	7.7
Haematopoietic and lymphoid	KMS26	6.3
Haematopoietic and lymphoid	KMS27	7.1
Haematopoietic and lymphoid	KMS28BM	7.1
Haematopoietic and lymphoid	KMS34	6.1
Haematopoietic and lymphoid	KO52	7.8
Haematopoietic and lymphoid	KOPN8	8.8
Haematopoietic and lymphoid	KU812	8.4
Haematopoietic and lymphoid	KYO1	8
Haematopoietic and lymphoid	L1236	7.2
Haematopoietic and lymphoid	L363	6.4
Haematopoietic and lymphoid	L428	7.7
Haematopoietic and lymphoid	L540	7.9
Haematopoietic and lymphoid	LAMA84	7.8
Haematopoietic and lymphoid	LOUCY	7.8
Haematopoietic and lymphoid	LP1	7.8
Haematopoietic and lymphoid	M07E	8.4
Haematopoietic and lymphoid	MC116	7.9
Haematopoietic and lymphoid	ME1	8.7
Haematopoietic and lymphoid	MEC1	7.9
Haematopoietic and lymphoid	MEC2	8.2
Haematopoietic and lymphoid	MEG01	7.7
Haematopoietic and lymphoid	MHHCALL2	8.1
Haematopoietic and lymphoid	MHHCALL3	8.3
Haematopoietic and lymphoid	MHHCALL4	8
Haematopoietic and lymphoid	MINO	8.6
Haematopoietic and lymphoid	MJ	7.7
Haematopoietic and lymphoid	MM1S	6.4
Haematopoietic and lymphoid	MOLM13	7.5
Haematopoietic and lymphoid	MOLM16	8.4
Haematopoietic and lymphoid	MOLM6	8.1
Haematopoietic and lymphoid	MOLP2	7.5
Haematopoietic and lymphoid	MOLP8	8.4
Haematopoietic and lymphoid	MOLT13	8
Haematopoietic and lymphoid	MOLT16	7.6
Haematopoietic and lymphoid	MOLT4	7.9
Haematopoietic and lymphoid	MONOMAC1	7.3
Haematopoietic and lymphoid	MONOMAC6	8
Haematopoietic and lymphoid	MOTN1	7.1
Haematopoietic and lymphoid	MUTZ5	8.1
Haematopoietic and lymphoid	MV411	8.4
Haematopoietic and lymphoid	NALM19	8.2
Haematopoietic and lymphoid	NALM1	8.3
Haematopoietic and lymphoid	NALM6	8.1
Haematopoietic and lymphoid	NAMALWA	8.9
Haematopoietic and lymphoid	NB4	8
Haematopoietic and lymphoid	NCIH929	6.5
Haematopoietic and lymphoid	NCO2	7.4
Haematopoietic and lymphoid	NOMO1	7.8
Haematopoietic and lymphoid	NUDHL1	8.6
Haematopoietic and lymphoid	NUDUL1	8.7
Haematopoietic and lymphoid	OCIAML2	7.7
Haematopoietic and lymphoid	OCIAML3	7.8
Haematopoietic and lymphoid	OCIAML5	7.9
Haematopoietic and lymphoid	OCILY10	8.3
Haematopoietic and lymphoid	OCILY19	8.7
Haematopoietic and lymphoid	OCILY3	7.2
Haematopoietic and lymphoid	OCIM1	7.1
Haematopoietic and lymphoid	OPM2	8.2
Haematopoietic and lymphoid	P12ICHIKAWA	7.9
Haematopoietic and lymphoid	P31FUJ	6.7
Haematopoietic and lymphoid	P3HR1	7.5
Haematopoietic and lymphoid	PCM6	7.2
Haematopoietic and lymphoid	PEER	8.2
Haematopoietic and lymphoid	PF382	7.6
Haematopoietic and lymphoid	PFEIFFER	8
Haematopoietic and lymphoid	PL21	7.7
Haematopoietic and lymphoid	RAJI	7.9
Haematopoietic and lymphoid	RCHACV	8.2
Haematopoietic and lymphoid	REC1	8.4
Haematopoietic and lymphoid	REH	8
Haematopoietic and lymphoid	RI1	7.8
Haematopoietic and lymphoid	RL	7.4
Haematopoietic and lymphoid	RPMI8226	6.1
Haematopoietic and lymphoid	RPMI8402	7.9
Haematopoietic and lymphoid	RS411	7.8
Haematopoietic and lymphoid	SEM	7.2
Haematopoietic and lymphoid	SET2	7.8
Haematopoietic and lymphoid	SIGM5	7.9
Haematopoietic and lymphoid	SKM1	7.2
Haematopoietic and lymphoid	SKMM2	7.6
Haematopoietic and lymphoid	SR786	7.4
Haematopoietic and lymphoid	ST486	8.4
Haematopoietic and lymphoid	SUDHL10	8.4
Haematopoietic and lymphoid	SUDHL1	8
Haematopoietic and lymphoid	SUDHL4	9
Haematopoietic and lymphoid	SUDHL5	8.1
Haematopoietic and lymphoid	SUDHL6	8.3
Haematopoietic and lymphoid	SUDHL8	8.4
Haematopoietic and lymphoid	SUPB15	7.5
Haematopoietic and lymphoid	SUPHD1	7.9
Haematopoietic and lymphoid	SUPM2	6.9
Haematopoietic and lymphoid	SUPT11	7.8
Haematopoietic and lymphoid	SUPT1	7.5
Haematopoietic and lymphoid	TALL1	9.1
Haematopoietic and lymphoid	TF1	8.5
Haematopoietic and lymphoid	THP1	7.3
Haematopoietic and lymphoid	TO175T	6.7
Haematopoietic and lymphoid	TOLEDO	8.3
Haematopoietic and lymphoid	U266B1	6.4
Haematopoietic and lymphoid	U937	7.6
Haematopoietic and lymphoid	UT7	7.4
Haematopoietic and lymphoid	WSUDLCL2	8.3
Kidney	769P	6.1
Kidney	786O	7
Kidney	A498	6.4
Kidney	A704	6
Kidney	ACHN	6.6
Kidney	BFTC909	7.2
Kidney	CAKI1	6.7
Kidney	CAKI2	6.7
Kidney	CAL54	7.2
Kidney	KMRC1	5.5
Kidney	KMRC20	5.9
Kidney	KMRC2	6.7
Kidney	KMRC3	6.6
Kidney	OSRC2	6.4
Kidney	RCC10RGB	6.6
Kidney	SNU1272	6.6
Kidney	SNU349	7
Kidney	TUHR10TKB	6.7
Kidney	TUHR14TKB	6.6
Kidney	TUHR4TKB	6
Kidney	VMRCRCW	6.3
Kidney	VMRCRCZ	6.6
Large intestine	C2BBE1	6.7
Large intestine	CCK81	7
Large intestine	CL11	7.9
Large intestine	CL14	6.4
Large intestine	CL34	7.9
Large intestine	CL40	6.8
Large intestine	COLO205	5.7
Large intestine	COLO320	8.3
Large intestine	COLO678	7.5
Large intestine	CW2	7.4
Large intestine	DLD1	6.6
Large intestine	GP2D	7.8
Large intestine	HCC56	6.8
Large intestine	HCT116	7.6
Large intestine	HCT15	7.3
Large intestine	HS675T	6.3
Large intestine	HS698T	6.8
Large intestine	HT115	7.7
Large intestine	HT29	7.9
Large intestine	HT55	6.8
Large intestine	KM12	8
Large intestine	LOVO	7.4
Large intestine	LS1034	7.1
Large intestine	LS123	6.8
Large intestine	LS180	6.7
Large intestine	LS411N	7.4
Large intestine	LS513	6.9
Large intestine	MDST8	6.9
Large intestine	NCIH508	7.2
Large intestine	NCIH716	7.6
Large intestine	NCIH747	6
Large intestine	OUMS23	7.2
Large intestine	RCM1	7.3
Large intestine	RKO	7.1
Large intestine	SKCO1	8.1
Large intestine	SNU1040	7.7
Large intestine	SNU1197	6.8
Large intestine	SNU175	7.7
Large intestine	SNU283	6.8
Large intestine	SNU407	7.8
Large intestine	SNU503	8.2
Large intestine	SNU61	7.9
Large intestine	SNU81	8.1
Large intestine	SNUC1	7
Large intestine	SNUC2A	6.8
Large intestine	SNUC4	7.5
Large intestine	SNUC5	7.9
Large intestine	SW1116	7.5
Large intestine	SW1417	6.6
Large intestine	SW1463	7.2
Large intestine	SW403	6.4
Large intestine	SW480	6.6
Large intestine	SW48	8.7
Large intestine	SW620	7.4
Large intestine	SW837	7.8
Large intestine	SW948	7
Large intestine	T84	7.9
Liver	ALEXANDERCELLS	6.2
Liver	C3A	6.7
Liver	HEP3B217	7.5
Liver	HEPG2	7.3
Liver	HLE	6.5
Liver	HLF	6.5
Liver	HUH1	6.5
Liver	HUH6	7.9
Liver	HUH7	6.2
Liver	JHH1	6.8
Liver	JHH2	6.4
Liver	JHH4	7.1
Liver	JHH5	7.2
Liver	JHH6	7.3
Liver	JHH7	6.9
Liver	LI7	6.4
Liver	PLCPRF5	6.8
Liver	SKHEP1	7.6
Liver	SNU182	7.3
Liver	SNU387	6.6
Liver	SNU398	8.3
Liver	SNU423	6.3
Liver	SNU449	7.3
Liver	SNU475	7.2
Liver	SNU761	6.7
Liver	SNU878	5.6
Liver	SNU886	7.2
Lung	A549	6.9
Lung	ABC1	6
Lung	BEN	6.4
Lung	CAL12T	7.5
Lung	CALU1	7.7
Lung	CALU3	7.1
Lung	CALU6	7.2
Lung	CHAGOK1	7.4
Lung	COLO668	7.7
Lung	COLO699	6.7
Lung	CORL105	7.6
Lung	CORL23	7.9
Lung	CORL24	7.5
Lung	CORL279	9.2
Lung	CORL311	7.8
Lung	CORL47	8.2
Lung	CORL51	7.8
Lung	CORL88	7.2
Lung	CORL95	6.8
Lung	CPCN	7.5
Lung	DMS114	6.9
Lung	DMS153	6.1
Lung	DMS273	8.4
Lung	DMS454	7.2
Lung	DMS53	6.1
Lung	DMS79	7.4
Lung	DV90	7.3
Lung	EBC1	7.2
Lung	EPLC272H	7
Lung	HARA	7.7
Lung	HCC1171	7.7
Lung	HCC1195	7.5
Lung	HCC15	7.4
Lung	HCC2279	6.8
Lung	HCC2935	7.7
Lung	HCC33	8.7
Lung	HCC366	7.2
Lung	HCC4006	7.2
Lung	HCC44	7.6
Lung	HCC78	6.7
Lung	HCC827	7.8
Lung	HCC95	7.3
Lung	HLC1	7.7
Lung	HLFA	6.5
Lung	HS229T	6.7
Lung	HS618T	6.6
Lung	IALM	7.7
Lung	KNS62	7.3
Lung	LC1F	7.6
Lung	LC1SQSF	7.6
Lung	LCLC103H	7.1
Lung	LCLC97TM1	8.3
Lung	LK2	7.3
Lung	LOUNH91	6.8
Lung	LU65	7
Lung	LU99	6.7
Lung	LUDLU1	7.8
Lung	LXF289	7.9
Lung	MORCPR	7.7
Lung	NCIH1048	7.5
Lung	NCIH1092	7.4
Lung	NCIH1105	7.7
Lung	NCIH1155	7
Lung	NCIH1184	7.5
Lung	NCIH1299	8.3
Lung	NCIH1339	7.2
Lung	NCIH1341	7.7
Lung	NCIH1355	7.1
Lung	NCIH1373	7.7
Lung	NCIH1385	6.7
Lung	NCIH1395	5.4
Lung	NCIH1435	7.1
Lung	NCIH1436	7.9
Lung	NCIH1437	8
Lung	NCIH146	7.7
Lung	NCIH1563	6.9
Lung	NCIH1568	7.4
Lung	NCIH1573	6.9
Lung	NCIH1581	9.1
Lung	NCIH1618	7.4
Lung	NCIH1623	7.6
Lung	NCIH1648	7.1
Lung	NCIH1650	7.2
Lung	NCIH1651	5.7
Lung	NCIH1666	7.1
Lung	NCIH1693	6.6
Lung	NCIH1694	8.8
Lung	NCIH1703	7.1
Lung	NCIH1734	7
Lung	NCIH1755	6.7
Lung	NCIH1781	9
Lung	NCIH1792	7.8
Lung	NCIH1793	7.2
Lung	NCIH1836	7.4
Lung	NCIH1838	6.7
Lung	NCIH1869	7.4
Lung	NCIH1876	7.3
Lung	NCIH1915	7.2
Lung	NCIH1930	7.6
Lung	NCIH1944	6.9
Lung	NCIH1963	7.8
Lung	NCIH196	7.3
Lung	NCIH1975	6.5
Lung	NCIH2009	7.4
Lung	NCIH2023	6.7
Lung	NCIH2029	5.8
Lung	NCIH2030	7.2
Lung	NCIH2066	7.3
Lung	NCIH2081	8
Lung	NCIH2085	7.1
Lung	NCIH2087	7.2
Lung	NCIH209	7.4
Lung	NCIH2106	7.4
Lung	NCIH2110	7
Lung	NCIH211	7
Lung	NCIH2122	7.3
Lung	NCIH2126	8.2
Lung	NCIH2141	9.2
Lung	NCIH2170	9
Lung	NCIH2171	8.3
Lung	NCIH2172	7.4
Lung	NCIH2196	6.5
Lung	NCIH2227	8
Lung	NCIH2228	7.2
Lung	NCIH226	6.7
Lung	NCIH2286	7.8
Lung	NCIH2291	6.3
Lung	NCIH2342	7.2
Lung	NCIH2347	7
Lung	NCIH23	7.2
Lung	NCIH2405	7.5
Lung	NCIH2444	8.3
Lung	NCIH292	7.4
Lung	NCIH322	7.4
Lung	NCIH3255	9.3
Lung	NCIH358	8.8
Lung	NCIH441	7
Lung	NCIH446	8.8
Lung	NCIH460	7.5
Lung	NCIH510	7.2
Lung	NCIH520	7.2
Lung	NCIH522	8
Lung	NCIH524	8.8
Lung	NCIH526	8.3
Lung	NCIH596	6.1
Lung	NCIH647	7.5
Lung	NCIH650	7.3
Lung	NCIH661	6.9
Lung	NCIH69	7.4
Lung	NCIH727	7.3
Lung	NCIH810	8.1
Lung	NCIH82	7.5
Lung	NCIH838	7.5
Lung	NCIH841	7.5
Lung	NCIH854	7.2
Lung	NCIH889	6
Lung	PC14	6.9
Lung	RERFLCAD1	5.9
Lung	RERFLCAD2	6.6
Lung	RERFLCAI	7.1
Lung	RERFLCKJ	6.8
Lung	RERFLCMS	6.6
Lung	RERFLCSQ1	7
Lung	SBC5	7.2
Lung	SCLC21H	9.3
Lung	SHP77	7.2
Lung	SKLU1	7.1
Lung	SKMES1	6.7
Lung	SQ1	7.8
Lung	SW1271	7.6
Lung	SW1573	7.1
Lung	SW900	6.9
Lung	VMRCLCD	7.8
Lung	VMRCLCP	8
Oesophagus	COLO680N	8.4
Oesophagus	ECGI10	7.6
Oesophagus	KYSE140	8.1
Oesophagus	KYSE150	8
Oesophagus	KYSE180	7.8
Oesophagus	KYSE270	8.2
Oesophagus	KYSE30	7.7
Oesophagus	KYSE410	7.7
Oesophagus	KYSE450	7.4
Oesophagus	KYSE510	8.2
Oesophagus	KYSE520	7.5
Oesophagus	KYSE70	7.3
Oesophagus	OE19	7.6
Oesophagus	OE33	6.4
Oesophagus	TE10	8.9
Oesophagus	TE11	7.4
Oesophagus	TE14	8.2
Oesophagus	TE15	7.2
Oesophagus	TE1	6.2
Oesophagus	TE4	7
Oesophagus	TE5	6.8
Oesophagus	TE6	9
Oesophagus	TE8	7.4
Oesophagus	TE9	7.4
Oesophagus	TT	7.4
Ovary	59M	7.6
Ovary	A2780	7.6
Ovary	CAOV3	7.6
Ovary	CAOV4	6.4
Ovary	COLO704	7.9
Ovary	COV318	7.9
Ovary	COV362	7.5
Ovary	COV434	7.6
Ovary	COV504	6.4
Ovary	COV644	5.6
Ovary	EFO21	8.1
Ovary	EFO27	7.4
Ovary	ES2	7
Ovary	FUOV1	7.7
Ovary	HEYA8	7.5
Ovary	HS571T	6.4
Ovary	IGROV1	6.5
Ovary	JHOC5	7.6
Ovary	JHOM1	7.8
Ovary	JHOM2B	7.4
Ovary	JHOS2	7.1
Ovary	JHOS4	6.6
Ovary	KURAMOCHI	8.1
Ovary	MCAS	7.3
Ovary	NIHOVCAR3	7.9
Ovary	OAW28	8.2
Ovary	OAW42	7.2
Ovary	OC314	7.8
Ovary	OC316	7.3
Ovary	ONCODG1	8.1
Ovary	OV56	6.7
Ovary	OV7	7.4
Ovary	OV90	7.7
Ovary	OVCAR4	7.1
Ovary	OVCAR8	7
Ovary	OVISE	6.9
Ovary	OVK18	7.8
Ovary	OVKATE	7.4
Ovary	OVMANA	7.1
Ovary	OVSAHO	7.9
Ovary	OVTOKO	7.1
Ovary	RMGI	8.5
Ovary	RMUGS	7.2
Ovary	SKOV3	7.1
Ovary	SNU119	7.1
Ovary	SNU840	7.8
Ovary	SNU8	7.7
Ovary	TOV112D	8.9
Ovary	TOV21G	7.5
Ovary	TYKNU	6.9
Pancreas	ASPC1	6.2
Pancreas	BXPC3	7.1
Pancreas	CAPAN1	7.7
Pancreas	CAPAN2	7.1
Pancreas	CFPAC1	7.4
Pancreas	DANG	7
Pancreas	HPAC	8.2
Pancreas	HPAFII	7.2
Pancreas	HS766T	6.8
Pancreas	HUPT3	7.1
Pancreas	HUPT4	7
Pancreas	KCIMOH1	6.7
Pancreas	KLM1	8.5
Pancreas	KP2	7.5
Pancreas	KP3	6.2
Pancreas	KP4	7.6
Pancreas	L33	8.1
Pancreas	MIAPACA2	8.6
Pancreas	PANC0203	7.4
Pancreas	PANC0213	7.2
Pancreas	PANC0327	7.1
Pancreas	PANC0403	6.5
Pancreas	PANC0504	7.5
Pancreas	PANC0813	6.7
Pancreas	PANC1005	6.4
Pancreas	PANC1	6.5
Pancreas	PATU8902	7.3
Pancreas	PATU8988S	7.1
Pancreas	PATU8988T	7.9
Pancreas	PK1	7.4
Pancreas	PK45H	6.9
Pancreas	PK59	6.9
Pancreas	PL45	6.2
Pancreas	PSN1	8.3
Pancreas	QGP1	6.2
Pancreas	SNU213	8
Pancreas	SNU324	7.8
Pancreas	SNU410	6.6
Pancreas	SU8686	7.1
Pancreas	SUIT2	7.5
Pancreas	SW1990	7.4
Pancreas	T3M4	6.8
Pancreas	TCCPAN2	7.5
Pancreas	YAPC	7.7
Pleura	ACCMESO1	6.7
Pleura	DM3	6.7
Pleura	ISTMES1	7.5
Pleura	ISTMES2	7
Pleura	JL1	6.9
Pleura	MPP89	7.1
Pleura	MSTO211H	7.4
Pleura	NCIH2052	6.6
Pleura	NCIH2452	6
Pleura	NCIH28	6.2
Prostate	22RV1	7
Prostate	DU145	7.3
Prostate	LNCAPCLONEFGC	7.7
Prostate	MDAPCA2B	7.3
Prostate	NCIH660	7.2
Prostate	PC3	7.6
Prostate	VCAP	7.3
Salivary gland	A253	6.9
Salivary gland	YD15	7.5
Skin	A101D	6.5
Skin	A2058	8.1
Skin	A375	7.3
Skin	C32	6.5
Skin	CHL1	7.4
Skin	CJM	8.4
Skin	COLO679	6.7
Skin	COLO741	6.3
Skin	COLO783	7.7
Skin	COLO792	6.2
Skin	COLO800	7
Skin	COLO818	6.3
Skin	COLO829	6.9
Skin	COLO849	8
Skin	G361	6.9
Skin	GRM	8.6
Skin	HMCB	7.6
Skin	HS294T	6.9
Skin	HS600T	6.3
Skin	HS688AT	6.4
Skin	HS695T	6.4
Skin	HS839T	6.3
Skin	HS852T	7.1
Skin	HS895T	6.2
Skin	HS934T	6.8
Skin	HS936T	6.6
Skin	HS939T	6.7
Skin	HS940T	6.4
Skin	HS944T	7.3
Skin	HT144	7.1
Skin	IGR1	7.1
Skin	IGR37	6.8
Skin	IGR39	6.5
Skin	IPC298	6.8
Skin	K029AX	5.9
Skin	LOXIMVI	8.1
Skin	MALME3M	6.5
Skin	MDAMB435S	6.6
Skin	MELHO	6.4
Skin	MELJUSO	5.9
Skin	MEWO	7.2
Skin	RPMI7951	6.5
Skin	RVH421	6.5
Skin	SH4	6.6
Skin	SKMEL1	4.6
Skin	SKMEL24	6.7
Skin	SKMEL28	6
Skin	SKMEL2	6.5
Skin	SKMEL30	6.6
Skin	SKMEL31	6.3
Skin	SKMEL3	6.5
Skin	SKMEL5	7.2
Skin	UACC257	6.9
Skin	UACC62	7.3
Skin	WM115	6.9
Skin	WM1799	7
Skin	WM2664	7.7
Skin	WM793	7.2
Skin	WM88	6.9
Skin	WM983B	6.8
Small intestine	HUTU80	8.1
Soft tissue	A204	7.5
Soft tissue	G401	7.7
Soft tissue	G402	7.6
Soft tissue	GCT	6.5
Soft tissue	HS729	7.1
Soft tissue	HT1080	7.2
Soft tissue	KYM1	8.3
Soft tissue	MESSA	7.2
Soft tissue	RD	7.5
Soft tissue	RH30	8.6
Soft tissue	RH41	8.1
Soft tissue	RKN	6.8
Soft tissue	S117	7
Soft tissue	SJRH30	7.9
Soft tissue	SKLMS1	7.2
Soft tissue	SKUT1	7.5
Soft tissue	TE125T	6.6
Soft tissue	TE159T	6.7
Soft tissue	TE441T	7.6
Soft tissue	TE617T	7.6
Stomach	2313287	7.7
Stomach	AGS	7.3
Stomach	AZ521	7.9
Stomach	ECC10	8.4
Stomach	ECC12	7.7
Stomach	FU97	7
Stomach	GCIY	6.4
Stomach	GSS	7.8
Stomach	GSU	8.4
Stomach	HGC27	8.3
Stomach	HS746T	7
Stomach	HUG1N	6.9
Stomach	IM95	7.4
Stomach	KATOIII	6.5
Stomach	KE39	7.4
Stomach	LMSU	7.4
Stomach	MKN1	7.5
Stomach	MKN45	8.2
Stomach	MKN74	7
Stomach	MKN7	6.9
Stomach	NCCSTCK140	7.7
Stomach	NCIN87	6.4
Stomach	NUGC2	7.5
Stomach	NUGC3	7.1
Stomach	NUGC4	7.2
Stomach	OCUM1	7.7
Stomach	RERFGC1B	6.4
Stomach	SH10TC	7.5
Stomach	SNU16	8
Stomach	SNU1	7.4
Stomach	SNU216	8.3
Stomach	SNU520	7.4
Stomach	SNU5	6.7
Stomach	SNU601	7.1
Stomach	SNU620	7.6
Stomach	SNU668	8.4
Stomach	SNU719	8.9
Stomach	TGBC11TKB	8.2
Thyroid	8305C	7.5
Thyroid	8505C	7.3
Thyroid	BCPAP	8.2
Thyroid	BHT101	7.5
Thyroid	CAL62	7.9
Thyroid	CGTHW1	7.6
Thyroid	FTC133	7.3
Thyroid	FTC238	6.8
Thyroid	ML1	6.8
Thyroid	SW579	7.7
Thyroid	TT2609C02	8.1
Thyroid	TT	7
Upper aerodigestive tract	BHY	7.5
Upper aerodigestive tract	BICR16	8.4
Upper aerodigestive tract	BICR18	7.2
Upper aerodigestive tract	BICR22	7.2
Upper aerodigestive tract	BICR31	6.7
Upper aerodigestive tract	BICR56	6.8
Upper aerodigestive tract	BICR6	7.5
Upper aerodigestive tract	CAL27	6.9
Upper aerodigestive tract	CAL33	7.7
Upper aerodigestive tract	DETROIT562	7.4
Upper aerodigestive tract	FADU	7.2
Upper aerodigestive tract	HS840T	6.9
Upper aerodigestive tract	HSC2	7.2
Upper aerodigestive tract	HSC3	7.1
Upper aerodigestive tract	HSC4	7.1
Upper aerodigestive tract	PECAPJ15	7.1
Upper aerodigestive tract	PECAPJ34CLONEC12	8.1
Upper aerodigestive tract	PECAPJ41CLONED2	6.4
Upper aerodigestive tract	PECAPJ49	7.2
Upper aerodigestive tract	SCC15	7.1
Upper aerodigestive tract	SCC25	7.6
Upper aerodigestive tract	SCC4	8.3
Upper aerodigestive tract	SCC9	6.9
Upper aerodigestive tract	SNU1076	7.5
Upper aerodigestive tract	SNU1214	7.4
Upper aerodigestive tract	SNU46	7.6
Upper aerodigestive tract	SNU899	7.3
Upper aerodigestive tract	YD10B	7.4
Upper aerodigestive tract	YD38	7.2
Upper aerodigestive tract	YD8	7.8
Urinary tract	5637	7.2
Urinary tract	639V	7.9
Urinary tract	647V	7.6
Urinary tract	BC3C	7.7
Urinary tract	BFTC905	8.6
Urinary tract	CAL29	7.1
Urinary tract	HS172T	6.3
Urinary tract	HT1197	7.1
Urinary tract	HT1376	6.7
Urinary tract	J82	7
Urinary tract	JMSU1	7.7
Urinary tract	KMBC2	7.1
Urinary tract	KU1919	8
Urinary tract	RT11284	7.5
Urinary tract	RT112	7.5
Urinary tract	RT4	7.2
Urinary tract	SCABER	6.4
Urinary tract	SW1710	6.5
Urinary tract	SW780	8.1
Urinary tract	T24	7.2
Urinary tract	TCCSUP	7.6
Urinary tract	UMUC1	7.8
Urinary tract	UMUC3	7.5
Urinary tract	VMCUB1	7.1

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	15.8
Adrenal gland	14.6
Appendix	14.7
Bone marrow	9.3
Breast	9.3
Cerebral cortex	20.8
Cervix, uterine	14.1
Colon	7.9
Duodenum	13.5
Endometrium	20.6
Epididymis	14.5
Esophagus	4.8
Fallopian tube	20.1
Gallbladder	9.5
Heart muscle	11
Kidney	5.9
Liver	3.4
Lung	12.6
Lymph node	14
Ovary	21.3
Pancreas	3.8
Parathyroid gland	13.2
Placenta	13.1
Prostate	17.2
Rectum	6.3
Salivary gland	7.6
Seminal vesicle	17.8
Skeletal muscle	6.7
Skin	13.8
Small intestine	13.2
Smooth muscle	13
Spleen	20.4
Stomach	10.5
Testis	35.8
Thyroid gland	9.7
Tonsil	8.7
Urinary bladder	6.3

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
27574100	Overexpression	Gastric Carcinoma	The expression of all the MTA family members was significantly increased in a stage-dependent manner, and elevated expression of all of the MTA family members was correlated with metastatic factors and prognosis in GC patients.
27035126	Overexpression	Oesophagal Squamous Cell Carcinoma	The expression of MTA1 protein in ESCC tissues was significantly higher than that of the adjacent tissues (42.1 vs. 11.2%; P<0.05), and was positively correlated with the tumor size, extent of tumor invasion and lymph node metastasis (P<0.05).
26878004	Overexpression	Malignant Salivary Gland Neoplasm	MTA1 expression in the malignant tumors was significantly higher than that in pleomorphic adenoma (P<0.001), and higher in pleomorphic adenoma than the normal salivary glands(P< 0.001). Our findings demonstrate that MTA1 was significantly overexpressed in malignant salivary gland neoplasm in comparison to a lower level in benign pleomorphic adenoma, suggesting that MTA1 protein might be involved in carcinogenesis.
26870192	Overexpression	Lung Adenocarcinoma	High protein expression levels of MTA1 were commonly observed in patients with lung invasive adenocarcinoma, and were significantly correlated with tumor size (P=0.030), lymph node metastasis (P=0.021) and microvessel density (P=0.015).
26689197	Overexpression	Malignant Pleural Mesothelioma	MTA1 expression is up-regulated in MPM and shown a negative correlation with E-cadherin expression.
26543080	Overexpression	Colorectal Carcinoma	The expression of MTA1 was significantly increased in CRC tissues compared to paired normal colorectal tissues, but decreased expression of MTA1 was correlated with poor prognosis (higher lymph node involvement stage, TNM stage, local invasion and recurrence) that was associated with increased expression of VEGFC and -D and the receptor VEGFR3.
25977170	Overexpression	Human Pituitary Adenoma	MTA1 was expressed at significantly higher levels in large tumors and in those with higher tumor grade.
25797255	Overexpression	Prostate Carcinoma	Importantly, YB-1 and MTA1 protein levels significantly increase the predictive capacity of a clinical model for prostate cancer recurrence.
25688501	Overexpression	Gall Bladder Adenocarcinoma	Positive MTA1 expression was significantly lower, but positive KAI-1 and KiSS-1 expressions were significantly higher in cases with well-differentiated adenocarcinoma, smaller tumor mass, no metastasis of lymph node, and no invasion of regional tissues than in cases having poorly differentiated adenocarcinoma, larger tumor mass, metastasis and invasion.
25502548	Overexpression	Small Cell Lung Cancer	First we demonstrated the overexpression of MTA1 in SCLC specimens.
25416046	Overexpression	Nasopharyngeal Carcinoma	Patients with high MTA1 expression exhibited significantly worse distant metastasis-free survival (DMFS) than those with low MTA1 expression (90.75% vs. 70.81%, P = 0.017).
25301048	Overexpression	Oral Squamous Cell Carcinoma	Frequency of MTA1 expression in SCCs was recorded as 97.7%, which was significantly higher than that of the control group (33.3%).
25100829	Overexpression	Nasopharyngeal Carcinoma	In this study, we reported the overexpression of MTA1 in 29/60 (48.3%) NPC patients, and the overexpression of MTA1 significantly correlated with tumor metastasis.
24599674	Overexpression	Non-Small Cell Lung Cancer	Moreover, multivariate survival analysis showed that MTA1 overexpression was an independent predictor of poor prognosis (HR=1.90, 95 % CI: 1.53-2.37, P<0.001). In addtional, MTA1 overexpression was significantly associated with tumor size (OR=2.72, 95 % CI=1.44-5.14, P=0.002), tumor stage (OR=2.44, 95 % CI=1.67-3.57, P<0.001), depth of invasion (OR=2.63, 95 % CI=1.74-3.97, P<0.001), and lymph node metastasis (OR=2.57, 95 % CI=1.57-4.19, P<0.001).
23900262	Overexpression	Prostate Carcinoma	We found that nuclear MTA1 overexpression was positively correlated with the severity of disease progression reaching its highest levels in metastatic PCa.
23866297	Overexpression	Cervical Carcinoma	High levels of MTA1 protein were clearly correlated with histologic grade (P = .006), lymph node metastasis (P = .001), and recurrence (P = .016).
23371285	Overexpression	Colorectal Carcinoma	IHC indicated low or no nuclear MTA1 expression in the normal tissues and significantly higher expression in Grade II, Grade III and liver metastasis tumors.
23227138	Overexpression	Prostate Carcinoma	RT-PCR analysis and Western blot assay showed that MTA1 expression is significantly higher in highly metastatic prostate cancer PC-3M-1E8 cells (1E8) than in poorly metastatic prostate cancer PC-3M-2B4 cells (2B4).
22864797	Overexpression	Breast Carcinoma	Breast cancer with lymph node metastasis (LNM) showed significantly higher frequency of overexpressed cyclin D1, β-catenin, and MTA1 (P < 0.05).
22844865	Overexpression	Nasopharyngeal Carcinoma	The positive expression of MTA1 in the NPC tissues and metastatic lymph nodes was significantly higher than that in the chronic nasopharyngitis tissues (p < 0.05).
22547301	Overexpression	Oesophagal Squamous Cell Carcinoma	MTA1 protein overexpression correlated with significantly worsened 5-year survival for all patients as well as those with T2 and T3 tumors, N0 nodal status or N1 nodal status.
22537306	Overexpression	Nasopharyngeal Carcinoma	Nuclear overexpression of MTA1 correlated positively with N classification (P = 0.02), clinical stage (P = 0.04), distant metastasis (P < 0.01) and death (P = 0.01).
22270988	Overexpression	Oesophagal Squamous Cell Carcinoma	Survival analysis showed that patients with MTA1 protein high expression had significantly poor overall 5-year survival (P = 0.002), and the factor found on multivariate analysis to significantly affect overall survival was only pathologic stage (P = 0.040).
22176993	Overexpression	Cervical Carcinoma	Compared with control group, MTA1 mRNA and protein were significantly overexpressed in MTA1 group, while MTA1-siRNA group showed lower MTA1 expression.
21949998	Overexpression	Nasopharyngeal Carcinoma	The MTA1 mRNA expression in NPC with lymph node metastasis was significantly higher than in NPC without lymph node metastasis (83.3% vs. 60.0%, P<0.05).
21448429	Overexpression	Colorectal Carcinoma	Additionally, high MTA1 expression level was correlated with a large tumor size (P < 0.05).
21290196	Overexpression	Non-Small Cell Lung Cancer	MTA1 protein overexpression and high MVD were significantly associated with tumor relapse (P = 0.004 and 0.007) and poor 5-year disease-free survival (P = 0.001 and 0.004).
21240515	Overexpression	Tonsil Carcinoma	There was a significant correlation between the expression of MTA1 and lymph node metastasis (P = 0.034*).
20935042	Overexpression	Non-Small Cell Lung Cancer	Tumor differentiation and tumor diameter were significantly associated with MTA1 protein overexpression, while not correlated with age, sex, pathological type or smoking status. The five-year survival rate of patients with MTA1 protein overexpression was significantly lower than that of those without expression (40.9% vs. 84.1%; P<0.001).
20717904	Overexpression	Prostate Carcinoma	MTA1 was expressed at higher levels in PCa cell lines than in normal prostate epithelial cells.
20661085	Overexpression	Non-Small Cell Lung Cancer	Overexpression of MTA1 (immunoreactivity scoring >4) was shown in 61.0% of the NSCLC cases but only in 9.4% of their adjacent nonneoplastic lung tissues (p < 0.001). The MTA1 expression level was correlated with lymph node metastasis (p = 0.013) and clinical stage (p = 0.002).
28570554	Overexpression	Digestive tract cancer	MTA1 overexpression was strongly associated with depth of invasion (OR = 1.88, 95%CI: 1.05-3.37, P = 0.03), lymph node metastasis (OR = 2.30, 95%CI: 1.76-3.01, P<0.001), vascular invasion (OR = 2.02, 95%CI: 1.40-2.91, P<0.001) and TNM stage (OR = 2.78, 95%CI: 1.63-4.74, P<0.001), and was related to 1- (RR = 1.84, 95%CI: 1.18-2.89, P = 0.008), 3- (RR = 1.74, 95%CI: 1.32-2.30, P<0.001) and 5-year (RR = 1.64, 95%CI: 1.18-2.27, P = 0.003) OS.
28506766	Overexpression	Prostate Carcinoma	Positive expression rate of MTA1 was upregulated in PC tissues, and expression of miR-183 and MTA1 was associated with differentiation, migration, tumor size, TNM.
28418915	Overexpression	Non-Small Cell Lung Carcinoma	Compared with normal lung tissues, MTA1 expression was elevated in NSCLC patient tissues and was correlated with American Joint Committee on Cancer stage, T stage, lymphatic metastasis, and patient overall survival.
28393842	Overexpression	Breast Carcinoma	In addition, MTA1 overexpression correlates well with low levels of DNMT3a which, in turn also correlates with a high IGFBP3 status in breast cancer patients and predicts a poor clinical outcome for breast cancer patients.

Summary
Symbol	MTA1
Name	metastasis associated 1
Aliases	metastasis associated gene 1 protein; Metastasis-associated protein MTA1
Location	14q32.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.523	8.7e-30	29.2	52	18.8	Neutral
BRCA	Breast invasive carcinoma	1075	0.463	2.46e-58	28.5	56	15.5	Neutral
CESC	Cervical and endocervical cancers	292	0.588	1.61e-28	16.4	66.1	17.5	Neutral
COAD	Colon adenocarcinoma	449	0.439	1.58e-22	32.7	59.9	7.3	Neutral
ESCA	Esophageal carcinoma	183	0.594	8.14e-19	30.1	40.4	29.5	Neutral
GBM	Glioblastoma multiforme	147	0.63	1.26e-17	32.7	61.2	6.1	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.598	3.8e-51	13.2	54.3	32.5	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.502	6.25e-35	42.5	54.5	3	Loss
KIRP	Kidney renal papillary cell carcinoma	288	0.445	2e-15	17.7	81.2	1	Neutral
LAML	Acute Myeloid Leukemia	166	0.2	0.0098	0	98.8	1.2	Neutral
LGG	Brain Lower Grade Glioma	513	0.502	4.66e-34	20.3	78.6	1.2	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.57	1.06e-32	36	58.2	5.8	Loss
LUAD	Lung adenocarcinoma	512	0.543	1.57e-40	29.3	47.5	23.2	Neutral
LUSC	Lung squamous cell carcinoma	498	0.628	4.94e-56	31.9	36.3	31.7	Neutral
OV	Ovarian serous cystadenocarcinoma	300	0.746	1.4e-54	35.3	36.3	28.3	Loss
PAAD	Pancreatic adenocarcinoma	177	0.409	1.65e-08	10.7	73.4	15.8	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.346	6.69e-06	15.4	82.1	2.5	Neutral
PRAD	Prostate adenocarcinoma	491	0.254	1.14e-08	7.1	89.2	3.7	Neutral
READ	Rectum adenocarcinoma	164	0.545	4.53e-14	41.5	51.2	7.3	Loss
SARC	Sarcoma	255	0.552	1.02e-21	24.3	47.8	27.8	Neutral
SKCM	Skin Cutaneous Melanoma	367	0.526	1.65e-27	31.6	55.6	12.8	Neutral
STAD	Stomach adenocarcinoma	413	0.457	9.63e-23	30.5	59.6	9.9	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.432	3.4e-08	16	48.7	35.3	Gain
THCA	Thyroid carcinoma	497	0.164	0.000232	0.2	97.4	2.4	Neutral
THYM	Thymoma	119	0.181	0.0486	1.7	87.4	10.9	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.488	1.87e-33	10.2	76.5	13.2	Neutral

Summary
Symbol	MTA1
Name	metastasis associated 1
Aliases	metastasis associated gene 1 protein; Metastasis-associated protein MTA1
Location	14q32.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.337	1.37e-12	17	408	-0.093	1.05e-16	NS/NA
BRCA	Breast invasive carcinoma	-0.219	7.88e-11	83	785	-0.011	1.38e-05	NS/NA
CESC	Cervical and endocervical cancers	-0.249	1.02e-05	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.186	0.000884	19	297	-0.145	1.55e-07	NS/NA
ESCA	Esophageal carcinoma	-0.232	0.00117	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.323	0.00893	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.247	6.07e-09	20	522	-0.004	0.376	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.318	2e-09	24	319	-0.029	1.57e-05	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.217	0.000166	23	275	-0.002	0.0548	NS/NA
LAML	Acute Myeloid Leukemia	-0.086	0.263	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.16	0.000226	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.308	1.78e-10	41	373	-0.024	2.25e-09	NS/NA
LUAD	Lung adenocarcinoma	-0.219	1.49e-06	21	456	-0.015	0.00015	NS/NA
LUSC	Lung squamous cell carcinoma	-0.289	1.19e-08	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.817	0.0108	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.254	0.000535	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.118	0.107	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.089	0.0393	35	498	0.041	1.2e-06	NS/NA
READ	Rectum adenocarcinoma	-0.223	0.0251	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.352	5.36e-09	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.299	4.18e-11	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.273	9.65e-08	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.307	0.000106	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.102	0.0158	50	509	0.001	0.812	NS/NA
THYM	Thymoma	-0.145	0.111	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.138	0.0029	34	431	0.026	0.681	NS/NA

Summary
Symbol	MTA1
Name	metastasis associated 1
Aliases	metastasis associated gene 1 protein; Metastasis-associated protein MTA1
Location	14q32.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	1	Low
Appendix	1	Low
Bone marrow	1	Low
Breast	1	Low
Bronchus	1	Low
Caudate	2	Medium
Cerebellum	3	High
Cerebral cortex	3	High
Cervix, uterine	0	Not detected
Colon	1	Low
Duodenum	1	Low
Endometrium	1	Low
Epididymis	1	Low
Esophagus	0	Not detected
Fallopian tube	2	Medium
Gallbladder	1	Low
Heart muscle	0	Not detected
Hippocampus	2	Medium
Kidney	1	Low
Liver	1	Low
Lung	1	Low
Lymph node	1	Low
Nasopharynx	1	Low
Oral mucosa	0	Not detected
Ovary	1	Low
Pancreas	1	Low
Parathyroid gland	1	Low
Placenta	1	Low
Prostate	0	Not detected
Rectum	1	Low
Salivary gland	1	Low
Seminal vesicle	1	Low
Skeletal muscle	0	Not detected
Skin	1	Low
Small intestine	1	Low
Smooth muscle	2	Medium
Soft tissue	0	Not detected
Spleen	0	Not detected
Stomach	1	Low
Testis	3	High
Thyroid gland	1	Low
Tonsil	1	Low
Urinary bladder	1	Low
Vagina	0	Not detected

Summary
Symbol	MTA1
Name	metastasis associated 1
Aliases	metastasis associated gene 1 protein; Metastasis-associated protein MTA1
Location	14q32.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.677	NS	24476821
BRCA	Breast invasive carcinoma	521	1.41e-05	Significant	23000897
COAD	Colon adenocarcinoma	149	0.147	NS	22810696
GBM	Glioblastoma multiforme	157	6.82e-10	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	2.38e-07	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.132	NS	26536169
LGG	Brain Lower Grade Glioma	513	1.29e-15	Significant	26824661
LUAD	Lung adenocarcinoma	230	0.00147	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	0.00171	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.0025	Significant	21720365
PRAD	Prostate adenocarcinoma	333	0.224	NS	26544944
READ	Rectum adenocarcinoma	67	0.975	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.118	NS	26091043
STAD	Stomach adenocarcinoma	277	0.451	NS	25079317
THCA	Thyroid carcinoma	391	0.0279	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.0179	Significant	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	0.979	0.92	NS
BRCA	Breast invasive carcinoma	1079	0.587	0.0346	Longer
CESC	Cervical and endocervical cancers	291	1.496	0.234	NS
COAD	Colon adenocarcinoma	439	1.331	0.31	NS
ESCA	Esophageal carcinoma	184	0.538	0.0791	NS
GBM	Glioblastoma multiforme	158	0.61	0.0523	NS
HNSC	Head and Neck squamous cell carcinoma	518	1.374	0.0907	NS
KIRC	Kidney renal clear cell carcinoma	531	1.593	0.0243	Shorter
KIRP	Kidney renal papillary cell carcinoma	287	1.897	0.191	NS
LAML	Acute Myeloid Leukemia	149	1.159	0.626	NS
LGG	Brain Lower Grade Glioma	511	0.434	0.00128	Longer
LIHC	Liver hepatocellular carcinoma	365	1.04	0.871	NS
LUAD	Lung adenocarcinoma	502	0.919	0.693	NS
LUSC	Lung squamous cell carcinoma	494	0.809	0.29	NS
OV	Ovarian serous cystadenocarcinoma	303	0.747	0.156	NS
PAAD	Pancreatic adenocarcinoma	177	0.397	0.0028	Longer
PCPG	Pheochromocytoma and Paraganglioma	179	1.562	0.722	NS
PRAD	Prostate adenocarcinoma	497	629491602.189	0.0286	Shorter
READ	Rectum adenocarcinoma	159	0.855	0.765	NS
SARC	Sarcoma	259	1.816	0.0349	Shorter
SKCM	Skin Cutaneous Melanoma	459	0.969	0.867	NS
STAD	Stomach adenocarcinoma	388	1.005	0.983	NS
TGCT	Testicular Germ Cell Tumors	134	0	0.153	NS
THCA	Thyroid carcinoma	500	1.077	0.916	NS
THYM	Thymoma	119	0.509	0.432	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	1.188	0.556	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	-0.048	0.334	NS
BRCA	Breast invasive carcinoma	1071	0.014	0.653	NS
CESC	Cervical and endocervical cancers	167	0.124	0.11	NS
COAD	Colon adenocarcinoma	445	-0.004	0.932	NS
ESCA	Esophageal carcinoma	162	-0.084	0.288	NS
HNSC	Head and Neck squamous cell carcinoma	448	0.082	0.0843	NS
KIRC	Kidney renal clear cell carcinoma	531	-0.049	0.262	NS
KIRP	Kidney renal papillary cell carcinoma	260	0.107	0.0837	NS
LIHC	Liver hepatocellular carcinoma	347	0.017	0.749	NS
LUAD	Lung adenocarcinoma	507	-0.003	0.949	NS
LUSC	Lung squamous cell carcinoma	497	0.139	0.00195	Higher
OV	Ovarian serous cystadenocarcinoma	302	-0.073	0.203	NS
PAAD	Pancreatic adenocarcinoma	176	-0.077	0.307	NS
READ	Rectum adenocarcinoma	156	-0.007	0.935	NS
SKCM	Skin Cutaneous Melanoma	410	-0.087	0.0774	NS
STAD	Stomach adenocarcinoma	392	-0.033	0.513	NS
TGCT	Testicular Germ Cell Tumors	81	0.013	0.91	NS
THCA	Thyroid carcinoma	499	0.03	0.499	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.006	0.902	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	0.182	0.00262	Higher
HNSC	Head and Neck squamous cell carcinoma	498	0.059	0.186	NS
KIRC	Kidney renal clear cell carcinoma	525	-0.113	0.0098	Lower
LGG	Brain Lower Grade Glioma	514	-0.078	0.0771	NS
LIHC	Liver hepatocellular carcinoma	366	-0.017	0.751	NS
OV	Ovarian serous cystadenocarcinoma	296	-0.005	0.936	NS
PAAD	Pancreatic adenocarcinoma	176	-0.03	0.691	NS
STAD	Stomach adenocarcinoma	406	-0.093	0.0602	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.025	0.568	NS

Summary
Symbol	MTA1
Name	metastasis associated 1
Aliases	metastasis associated gene 1 protein; Metastasis-associated protein MTA1
Location	14q32.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	MTA1
Name	metastasis associated 1
Aliases	metastasis associated gene 1 protein; Metastasis-associated protein MTA1
Location	14q32.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for MTA1.

Summary
Symbol	MTA1
Name	metastasis associated 1
Aliases	metastasis associated gene 1 protein; Metastasis-associated protein MTA1
Location	14q32.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]
There is no record for MTA1.

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
26689197	Malignant Pleural Mesothelioma	partner	E-cadherin	Negative Correlation	MTA1 expression is up-regulated in MPM and shown a negative correlation with E-cadherin expression.
26543080	Colorectal Carcinoma	partner	VEGFC; VEGFD; VEGFR3	Negative Correlation	The expression of MTA1 was significantly increased in CRC tissues compared to paired normal colorectal tissues, but decreased expression of MTA1 was correlated with poor prognosis (higher lymph node involvement stage, TNM stage, local invasion and recurrence) that was associated with increased expression of VEGFC and -D and the receptor VEGFR3.
25100829	Nasopharyngeal Carcinoma	downstream	EMT; Wnt1 pathway; β-catenin activation.	positive regulation	The overexpression of MTA1 promoted EMT via the Wnt1 pathway and β-catenin activation.
21448429	Colorectal Carcinoma	partner	VEGF-C	Positive correlation	A significant correlation was found between MTA1 and VEGF-C protein expressions in tumor cells (r = 0.371, P < 0.05).
28506766	Prostate Carcinoma	upstream	miR-183	Negative regulation	Our study supported that miR-183 could repress EMT and invasion of human PC cells through inhibition of MTA1 expression.
28418915	Non-Small Cell Lung Carcinoma	downstream	E-cadherin; Claudin-1; ZO-1; Vimentin; AKT/GSK3β/β-catenin signaling.	Negative regulation; negative regulation; negative reegulation; positive regulation; positive regulation	MTA1 overexpression decreased E-cadherin, Claudin-1, and ZO-1 levels and increased Vimentin expression in vitro and in vivo, through activation of AKT/GSK3β/β-catenin signaling.
28393842	Breast Carcinoma	partner	HDAC1/YY1 transcriptor factor complex	Collaboration	We discovered that MTA1 represses DNMT3a expression via HDAC1/YY1 transcription factor complex.
28393842	Breast Carcinoma	downstream	DNMT3a; IGFBP3	Negative regulation; positive regulation	In addition, MTA1 overexpression correlates well with low levels of DNMT3a which, in turn also correlates with a high IGFBP3 status in breast cancer patients and predicts a poor clinical outcome for breast cancer patients. We discovered that MTA1 represses DNMT3a expression via HDAC1/YY1 transcription factor complex. These findings suggest that MTA1 could regulate the expression of IGFBP3 in both DNMT3a-dependent and -independent manner.