CR2Cancer

Summary
Symbol	MTA2
Name	metastasis associated 1 family member 2
Aliases	MTA1-L1; MTA1L1; metastasis associated gene family, member 2; PID; MTA1-L1 protein; metastasis -associated g ......
Location	11q12.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

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Domain

PF01426 BAH domain
PF01448 ELM2 domain
PF00320 GATA zinc finger

Function

May be involved in the regulation of gene expression as repressor and activator. The repression might be related to covalent modification of histone proteins.

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification erase cofactor	Histone acetylation	#	#	10444591

> Gene Ontology [ TOP ]
Biological Process	GO:0001667 ameboidal-type cell migration GO:0006304 DNA modification GO:0006305 DNA alkylation GO:0006306 DNA methylation GO:0006333 chromatin assembly or disassembly GO:0006338 chromatin remodeling GO:0006476 protein deacetylation GO:0010761 fibroblast migration GO:0010762 regulation of fibroblast migration GO:0016570 histone modification GO:0016575 histone deacetylation GO:0032259 methylation GO:0035601 protein deacylation GO:0043044 ATP-dependent chromatin remodeling GO:0043414 macromolecule methylation GO:0044728 DNA methylation or demethylation GO:0072331 signal transduction by p53 class mediator GO:0098732 macromolecule deacylation GO:1901796 regulation of signal transduction by p53 class mediator
Molecular Function	GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000987 core promoter proximal region sequence-specific DNA binding GO:0001085 RNA polymerase II transcription factor binding GO:0001103 RNA polymerase II repressing transcription factor binding GO:0001158 enhancer sequence-specific DNA binding GO:0001159 core promoter proximal region DNA binding GO:0003682 chromatin binding GO:0004407 histone deacetylase activity GO:0008134 transcription factor binding GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides GO:0019213 deacetylase activity GO:0031490 chromatin DNA binding GO:0031491 nucleosome binding GO:0031492 nucleosomal DNA binding GO:0033558 protein deacetylase activity GO:0035326 enhancer binding GO:0042826 histone deacetylase binding GO:0043566 structure-specific DNA binding GO:0070491 repressing transcription factor binding
Cellular Component	GO:0000118 histone deacetylase complex GO:0000785 chromatin GO:0000790 nuclear chromatin GO:0005667 transcription factor complex GO:0016581 NuRD complex GO:0017053 transcriptional repressor complex GO:0044454 nuclear chromosome part GO:0070603 SWI/SNF superfamily-type complex GO:0090545 CHD-type complex GO:0090568 nuclear transcriptional repressor complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-427389: ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-212165: Epigenetic regulation of gene expression R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-3214815: HDACs deacetylate histones R-HSA-5250913: Positive epigenetic regulation of rRNA expression R-HSA-73854: RNA Polymerase I Promoter Clearance R-HSA-73864: RNA Polymerase I Transcription R-HSA-73762: RNA Polymerase I Transcription Initiation R-HSA-504046: RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription R-HSA-5633007: Regulation of TP53 Activity R-HSA-6804758: Regulation of TP53 Activity through Acetylation R-HSA-3700989: Transcriptional Regulation by TP53

> KEGG and Reactome Pathway

[ TOP ]

KEGG

Reactome

R-HSA-3247509: Chromatin modifying enzymes
R-HSA-4839726: Chromatin organization
R-HSA-427389: ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
R-HSA-212165: Epigenetic regulation of gene expression
R-HSA-74160: Gene Expression
R-HSA-212436: Generic Transcription Pathway
R-HSA-3214815: HDACs deacetylate histones
R-HSA-5250913: Positive epigenetic regulation of rRNA expression
R-HSA-73854: RNA Polymerase I Promoter Clearance
R-HSA-73864: RNA Polymerase I Transcription
R-HSA-73762: RNA Polymerase I Transcription Initiation
R-HSA-504046: RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
R-HSA-5633007: Regulation of TP53 Activity
R-HSA-6804758: Regulation of TP53 Activity through Acetylation
R-HSA-3700989: Transcriptional Regulation by TP53

Summary
Symbol	MTA2
Name	metastasis associated 1 family member 2
Aliases	MTA1-L1; MTA1L1; metastasis associated gene family, member 2; PID; MTA1-L1 protein; metastasis -associated g ......
Location	11q12.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM386436	c.1936C>T	p.R646W	Substitution - Missense	Lung
COSM2038997	c.385delT	p.Y129fs*33	Deletion - Frameshift	Large_intestine
COSM1704146	c.1453C>T	p.P485S	Substitution - Missense	Skin
COSM5050965	c.950T>A	p.I317N	Substitution - Missense	Stomach
COSM5492805	c.436G>A	p.E146K	Substitution - Missense	Biliary_tract
COSM1604908	c.1493G>A	p.R498Q	Substitution - Missense	Liver
COSM1322301	c.1151C>G	p.P384R	Substitution - Missense	Ovary
COSM3869750	c.133C>T	p.L45F	Substitution - Missense	Skin
COSM240733	c.1843G>C	p.A615P	Substitution - Missense	Prostate
COSM929717	c.1463C>T	p.A488V	Substitution - Missense	Endometrium
COSM2038987	c.877G>T	p.D293Y	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM301378	c.479G>A	p.R160H	Substitution - Missense	Large_intestine
COSM3980504	c.593+9T>G	p.?	Unknown	Ovary
COSM1676100	c.311G>A	p.G104E	Substitution - Missense	Large_intestine
COSM2038973	c.1600delA	p.T534fs*25	Deletion - Frameshift	Large_intestine
COSM3670836	c.1889G>C	p.R630P	Substitution - Missense	Prostate
COSM4994322	c.1718C>A	p.S573Y	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM245787	c.406G>A	p.V136M	Substitution - Missense	Prostate
COSM2038997	c.385delT	p.Y129fs*33	Deletion - Frameshift	Breast
COSM4453596	c.319A>T	p.S107C	Substitution - Missense	Skin
COSM4703493	c.657C>G	p.H219Q	Substitution - Missense	Large_intestine
COSM5369174	c.1262A>C	p.H421P	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4034792	c.765G>T	p.Q255H	Substitution - Missense	Stomach
COSM2038970	c.1664delG	p.G555fs*4	Deletion - Frameshift	Large_intestine
COSM5800837	c.741G>T	p.K247N	Substitution - Missense	Breast
COSM929716	c.1782G>A	p.Q594Q	Substitution - coding silent	Endometrium
COSM3451013	c.457T>C	p.Y153H	Substitution - Missense	Skin
COSM5633670	c.163C>T	p.L55F	Substitution - Missense	Oesophagus
COSM1355398	c.139C>T	p.R47W	Substitution - Missense	Large_intestine
COSM3451007	c.1906C>T	p.L636L	Substitution - coding silent	Skin
COSM2157502	c.785G>A	p.R262Q	Substitution - Missense	Central_nervous_system
COSM4381997	c.343G>C	p.D115H	Substitution - Missense	Large_intestine
COSM467142	c.222G>C	p.G74G	Substitution - coding silent	Kidney
COSM3451014	c.93C>T	p.N31N	Substitution - coding silent	Skin
COSM5893568	c.491-6C>T	p.?	Unknown	Skin
COSM3666472	c.1016+5G>A	p.?	Unknown	Liver
COSM1676099	c.809C>T	p.A270V	Substitution - Missense	Large_intestine
COSM3687439	c.1323C>T	p.A441A	Substitution - coding silent	Large_intestine
COSM124514	c.1409G>T	p.R470M	Substitution - Missense	Upper_aerodigestive_tract
COSM689194	c.1746G>C	p.G582G	Substitution - coding silent	Lung
COSM4432285	c.1070A>G	p.N357S	Substitution - Missense	Oesophagus
COSM929720	c.1017-1G>A	p.?	Unknown	Large_intestine
COSM5893568	c.491-6C>T	p.?	Unknown	Skin
COSM929720	c.1017-1G>A	p.?	Unknown	Endometrium
COSM1604908	c.1493G>A	p.R498Q	Substitution - Missense	Liver
COSM1746392	c.221G>A	p.G74E	Substitution - Missense	Urinary_tract
COSM1746392	c.221G>A	p.G74E	Substitution - Missense	Urinary_tract
COSM1317289	c.866A>G	p.D289G	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM71701	c.339G>T	p.E113D	Substitution - Missense	Ovary
COSM4419863	c.373-6T>C	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM5739286	c.1407C>A	p.C469*	Substitution - Nonsense	Small_intestine
COSM2039002	c.238C>T	p.R80C	Substitution - Missense	Large_intestine
COSM5373090	c.28G>A	p.D10N	Substitution - Missense	Skin
COSM3788018	c.405C>T	p.P135P	Substitution - coding silent	Skin
COSM3451011	c.1488C>T	p.S496S	Substitution - coding silent	Skin
COSM3791702	c.982G>C	p.D328H	Substitution - Missense	Urinary_tract
COSM124515	c.421C>T	p.L141F	Substitution - Missense	Upper_aerodigestive_tract
COSM5807373	c.174G>T	p.L58L	Substitution - coding silent	Liver
COSM929715	c.1994T>A	p.V665D	Substitution - Missense	Endometrium
COSM121227	c.435C>T	p.G145G	Substitution - coding silent	Upper_aerodigestive_tract
COSM3809832	c.1913T>G	p.V638G	Substitution - Missense	Breast
COSM2038997	c.385delT	p.Y129fs*33	Deletion - Frameshift	Large_intestine
COSM4146005	c.466G>T	p.E156*	Substitution - Nonsense	Thyroid
COSM5882106	c.694-1G>T	p.?	Unknown	Breast
COSM1234964	c.848A>G	p.Y283C	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1355396	c.325A>G	p.T109A	Substitution - Missense	Large_intestine
COSM139905	c.656A>C	p.H219P	Substitution - Missense	Skin
COSM467141	c.1298G>A	p.S433N	Substitution - Missense	Kidney
COSM3451012	c.1041C>T	p.I347I	Substitution - coding silent	Skin
COSM2038989	c.822G>C	p.M274I	Substitution - Missense	Soft_tissue
COSM1746393	c.188C>T	p.A63V	Substitution - Missense	Urinary_tract
COSM3359277	c.1832A>T	p.K611M	Substitution - Missense	Pancreas
COSM1746393	c.188C>T	p.A63V	Substitution - Missense	Urinary_tract
COSM5221791	c.129_130delCT	p.C44fs*9	Deletion - Frameshift	Breast
COSM5369657	c.469A>G	p.I157V	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1197644	c.373G>T	p.D125Y	Substitution - Missense	Lung
COSM929722	c.256C>A	p.R86R	Substitution - coding silent	Endometrium
COSM4436973	c.718delA	p.R240fs*41	Deletion - Frameshift	Oesophagus
COSM5516562	c.1922C>T	p.T641M	Substitution - Missense	Biliary_tract
COSM5624197	c.182G>A	p.S61N	Substitution - Missense	Oesophagus
COSM5508387	c.1877G>A	p.R626Q	Substitution - Missense	Biliary_tract
COSM1286292	c.1678C>T	p.R560W	Substitution - Missense	Autonomic_ganglia
COSM929718	c.1442G>A	p.R481Q	Substitution - Missense	Endometrium
COSM4779365	c.312G>A	p.G104G	Substitution - coding silent	Liver
COSM4146004	c.1357A>C	p.T453P	Substitution - Missense	Thyroid
COSM1179316	c.1232A>G	p.E411G	Substitution - Missense	Prostate
COSM1355392	c.1850G>A	p.R617Q	Substitution - Missense	Large_intestine
COSM1676099	c.809C>T	p.A270V	Substitution - Missense	Large_intestine
COSM4703494	c.301delC	p.H101fs*8	Deletion - Frameshift	Large_intestine
COSM2157502	c.785G>A	p.R262Q	Substitution - Missense	Central_nervous_system
COSM4637636	c.1578C>T	p.A526A	Substitution - coding silent	Large_intestine
COSM1676099	c.809C>T	p.A270V	Substitution - Missense	Large_intestine
COSM5495116	c.272C>T	p.S91F	Substitution - Missense	Biliary_tract
COSM3451009	c.1603C>T	p.P535S	Substitution - Missense	Skin
COSM2038998	c.317G>A	p.C106Y	Substitution - Missense	Upper_aerodigestive_tract
COSM3451010	c.1531C>T	p.P511S	Substitution - Missense	Skin
COSM232821	c.1507G>A	p.A503T	Substitution - Missense	Skin
COSM1234964	c.848A>G	p.Y283C	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3809833	c.438G>A	p.E146E	Substitution - coding silent	Breast
COSM4606069	c.881T>C	p.F294S	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4034788	c.2005T>A	p.*669R	Nonstop extension	Stomach
COSM4891735	c.1769C>G	p.A590G	Substitution - Missense	Upper_aerodigestive_tract
COSM4034789	c.1853A>G	p.K618R	Substitution - Missense	Stomach
COSM5373088	c.1750C>T	p.R584C	Substitution - Missense	Soft_tissue
COSM3666472	c.1016+5G>A	p.?	Unknown	Liver
COSM121226	c.534C>T	p.V178V	Substitution - coding silent	Upper_aerodigestive_tract
COSM1197644	c.373G>T	p.D125Y	Substitution - Missense	Lung
COSM5373089	c.1444C>T	p.P482S	Substitution - Missense	Skin
COSM4146002	c.1965A>C	p.S655S	Substitution - coding silent	Thyroid
COSM5458263	c.701C>T	p.A234V	Substitution - Missense	Large_intestine
COSM5177080	c.1698delA	p.A568fs*29	Deletion - Frameshift	Large_intestine
COSM1676100	c.311G>A	p.G104E	Substitution - Missense	Large_intestine
COSM4034791	c.1560C>T	p.I520I	Substitution - coding silent	Stomach
COSM929721	c.910G>T	p.V304F	Substitution - Missense	Endometrium
COSM5373088	c.1750C>T	p.R584C	Substitution - Missense	Skin
COSM5560496	c.1403T>C	p.M468T	Substitution - Missense	Prostate
COSM4475515	c.1996C>T	p.L666L	Substitution - coding silent	Skin
COSM4703492	c.1986G>A	p.E662E	Substitution - coding silent	Large_intestine
COSM929719	c.1321G>A	p.A441T	Substitution - Missense	Endometrium
COSM4509999	c.823C>T	p.L275L	Substitution - coding silent	Skin
COSM4952964	c.685A>G	p.I229V	Substitution - Missense	Liver
COSM1355397	c.307C>T	p.R103W	Substitution - Missense	Large_intestine
COSM4034790	c.1701G>A	p.G567G	Substitution - coding silent	Stomach
COSM5042408	c.1663G>A	p.G555S	Substitution - Missense	Liver
COSM4034793	c.570C>T	p.I190I	Substitution - coding silent	Stomach
COSM1676099	c.809C>T	p.A270V	Substitution - Missense	Large_intestine
COSM4952964	c.685A>G	p.I229V	Substitution - Missense	Liver
COSM109363	c.299C>T	p.T100I	Substitution - Missense	Skin
COSM429447	c.1068G>A	p.M356I	Substitution - Missense	Breast
COSM5483622	c.692T>C	p.L231P	Substitution - Missense	Large_intestine
COSM4400131	c.1176T>G	p.A392A	Substitution - coding silent	Skin
COSM4146003	c.1916A>C	p.K639T	Substitution - Missense	Thyroid
COSM3869749	c.1718C>T	p.S573F	Substitution - Missense	Skin
COSM3967695	c.889T>C	p.W297R	Substitution - Missense	Central_nervous_system
COSM363221	c.1375A>G	p.T459A	Substitution - Missense	Lung
COSM1298310	c.790G>A	p.E264K	Substitution - Missense	Urinary_tract
COSM5935751	c.190+3G>A	p.?	Unknown	Skin
COSM299754	c.1142G>A	p.W381*	Substitution - Nonsense	Large_intestine
COSM4606069	c.881T>C	p.F294S	Substitution - Missense	Upper_aerodigestive_tract
COSM4846536	c.1197G>C	p.K399N	Substitution - Missense	Cervix
COSM4529406	c.1609G>A	p.G537S	Substitution - Missense	Skin
COSM5940153	c.594-7C>T	p.?	Unknown	Skin
COSM3359277	c.1832A>T	p.K611M	Substitution - Missense	Kidney
COSM1355397	c.307C>T	p.R103W	Substitution - Missense	Large_intestine
COSM2038978	c.1438C>T	p.R480*	Substitution - Nonsense	Skin
COSM4489919	c.354C>T	p.S118S	Substitution - coding silent	Skin
COSM4617165	c.1923G>A	p.T641T	Substitution - coding silent	Large_intestine
COSM1322300	c.694-1G>C	p.?	Unknown	Ovary
COSM6000037	c.1889G>A	p.R630H	Substitution - Missense	Prostate
COSM1355393	c.1664_1665insG	p.I556fs*8	Insertion - Frameshift	Large_intestine
COSM3788018	c.405C>T	p.P135P	Substitution - coding silent	Pancreas
COSM2038970	c.1664delG	p.G555fs*4	Deletion - Frameshift	Large_intestine
COSM5621295	c.847T>C	p.Y283H	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3809834	c.430C>T	p.Q144*	Substitution - Nonsense	Breast
COSM1725148	c.92A>G	p.N31S	Substitution - Missense	Liver
COSM5485486	c.1506C>T	p.A502A	Substitution - coding silent	Large_intestine
COSM3967694	c.1874T>G	p.M625R	Substitution - Missense	Central_nervous_system
COSM3451008	c.1683C>T	p.A561A	Substitution - coding silent	Skin

> Text Mining based Variations [ TOP ]
There is no record for MTA2.

Summary
Symbol	MTA2
Name	metastasis associated 1 family member 2
Aliases	MTA1-L1; MTA1L1; metastasis associated gene family, member 2; PID; MTA1-L1 protein; metastasis -associated g ......
Location	11q12.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

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Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
O94776	54	S	Phosphoserine	-	No	None detected
O94776	152	K	N6-acetyllysine	-	No	None detected
O94776	433	S	Phosphoserine	-	Yes	p.S433N (cancer: KIRC)
O94776	435	S	Phosphoserine	-	Yes	p.S435Y (cancer: BLCA); p.SP435fs (cancer: LGG)
O94776	460	K	N6-acetyllysine	-	No	None detected
O94776	522	K	N6-acetyllysine	-	No	None detected
O94776	531	K	N6-acetyllysine	-	No	None detected
O94776	534	T	Phosphothreonine	-	No	None detected
O94776	548	S	Phosphoserine	-	Yes	p.S548F (cancer: HNSC)

Summary
Symbol	MTA2
Name	metastasis associated 1 family member 2
Aliases	MTA1-L1; MTA1L1; metastasis associated gene family, member 2; PID; MTA1-L1 protein; metastasis -associated g ......
Location	11q12.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

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Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	7.064	7.444	0.457	4.69e-05	NS
BRCA	Breast invasive carcinoma	112	1100	6.402	6.777	0.429	6.53e-19	NS
CESC	Cervical and endocervical cancers	3	306	6.537	7.464	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	6.694	6.948	0.302	1.48e-05	NS
ESCA	Esophageal carcinoma	11	185	6.08	6.759	0.506	0.00408	NS
GBM	Glioblastoma multiforme	5	166	6.095	6.601	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	7.287	7.177	0.143	0.0708	NS
KIRC	Kidney renal clear cell carcinoma	72	534	5.823	6.13	0.28	9.15e-10	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	5.922	6.16	0.223	0.000354	NS
LAML	Acute Myeloid Leukemia	0	173	NA	7.036	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	6.701	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	5.387	5.476	0.081	0.182	NS
LUAD	Lung adenocarcinoma	59	517	6.283	6.598	0.358	1.67e-10	NS
LUSC	Lung squamous cell carcinoma	51	501	6.246	7.151	0.874	4.45e-33	Over
OV	Ovarian serous cystadenocarcinoma	0	307	NA	6.802	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	6.571	6.546	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	6.594	6.539	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	6.487	6.739	0.236	1.83e-07	NS
READ	Rectum adenocarcinoma	10	167	6.476	6.851	0.355	0.0127	NS
SARC	Sarcoma	2	263	5.951	6.582	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	6.988	6.805	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	6.654	6.831	0.176	0.053	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	6.377	NA	NA	NA
THCA	Thyroid carcinoma	59	509	5.655	6.109	0.402	2.83e-24	NS
THYM	Thymoma	2	120	7.492	7.862	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	6.492	7.172	0.697	5.44e-17	Over

> Cancer Cell Line Encyclopedia (CCLE)

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Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	4.7
Autonomic ganglia	CHP212	4.9
Autonomic ganglia	IMR32	4.9
Autonomic ganglia	KELLY	4.8
Autonomic ganglia	KPNRTBM1	4.9
Autonomic ganglia	KPNSI9S	4.7
Autonomic ganglia	KPNYN	5
Autonomic ganglia	MHHNB11	4.5
Autonomic ganglia	NB1	6
Autonomic ganglia	NH6	4.6
Autonomic ganglia	SHSY5Y	4.6
Autonomic ganglia	SIMA	5.2
Autonomic ganglia	SKNAS	5.3
Autonomic ganglia	SKNBE2	4.9
Autonomic ganglia	SKNDZ	4.8
Autonomic ganglia	SKNFI	4.5
Autonomic ganglia	SKNSH	5
Biliary tract	HUCCT1	5.7
Biliary tract	HUH28	4.4
Biliary tract	SNU1079	4.1
Biliary tract	SNU1196	6.4
Biliary tract	SNU245	6.1
Biliary tract	SNU308	6.5
Biliary tract	SNU478	5.7
Bone	143B	4.8
Bone	A673	5.7
Bone	CADOES1	5.3
Bone	CAL78	5
Bone	G292CLONEA141B1	6
Bone	HOS	5
Bone	HS706T	5.1
Bone	HS737T	4.5
Bone	HS819T	4.4
Bone	HS821T	5.5
Bone	HS822T	4.1
Bone	HS863T	5.1
Bone	HS870T	4.3
Bone	HS888T	5.6
Bone	MG63	5.3
Bone	MHHES1	4.9
Bone	OUMS27	4.7
Bone	RDES	5.5
Bone	SJSA1	5.1
Bone	SKES1	5.4
Bone	SKNMC	5.6
Bone	SW1353	4.4
Bone	T173	4.6
Bone	TC71	5.3
Bone	U2OS	5.2
Breast	AU565	6.2
Breast	BT20	5.4
Breast	BT474	4.9
Breast	BT483	5.3
Breast	BT549	5.3
Breast	CAL120	5.4
Breast	CAL148	5.8
Breast	CAL51	7.7
Breast	CAL851	5
Breast	CAMA1	5
Breast	DU4475	5.4
Breast	EFM192A	5
Breast	EFM19	5.2
Breast	EVSAT	5.2
Breast	HCC1143	4.8
Breast	HCC1187	5.1
Breast	HCC1395	4.6
Breast	HCC1419	6.4
Breast	HCC1428	5.9
Breast	HCC1500	5.3
Breast	HCC1569	5.4
Breast	HCC1599	4.7
Breast	HCC1806	4.8
Breast	HCC1937	5
Breast	HCC1954	5.8
Breast	HCC202	4.7
Breast	HCC2157	5.2
Breast	HCC2218	5.6
Breast	HCC38	4.4
Breast	HCC70	4.9
Breast	HDQP1	4.7
Breast	HMC18	5.6
Breast	HS274T	5
Breast	HS281T	5.3
Breast	HS343T	5.7
Breast	HS578T	4.8
Breast	HS606T	4.5
Breast	HS739T	4.1
Breast	HS742T	4.4
Breast	JIMT1	6
Breast	KPL1	5.3
Breast	MCF7	5.1
Breast	MDAMB134VI	4.7
Breast	MDAMB157	4.7
Breast	MDAMB175VII	4.4
Breast	MDAMB231	5
Breast	MDAMB361	5.4
Breast	MDAMB415	4.9
Breast	MDAMB436	5
Breast	MDAMB453	6.1
Breast	MDAMB468	5.6
Breast	SKBR3	5.8
Breast	T47D	5
Breast	UACC812	4.9
Breast	UACC893	5.1
Breast	YMB1	4.8
Breast	ZR751	4.4
Breast	ZR7530	5.2
Central nervous system	1321N1	5.1
Central nervous system	42MGBA	5.9
Central nervous system	8MGBA	5.1
Central nervous system	A172	4.8
Central nervous system	AM38	5.3
Central nervous system	BECKER	4.9
Central nervous system	CAS1	4.8
Central nervous system	CCFSTTG1	4.3
Central nervous system	D283MED	5.3
Central nervous system	D341MED	4.1
Central nervous system	DAOY	4.8
Central nervous system	DBTRG05MG	4.6
Central nervous system	DKMG	4.7
Central nervous system	GAMG	5.1
Central nervous system	GB1	6
Central nervous system	GI1	4.6
Central nervous system	GMS10	5
Central nervous system	GOS3	4.5
Central nervous system	H4	4.6
Central nervous system	HS683	4.4
Central nervous system	KALS1	4.9
Central nervous system	KG1C	4.7
Central nervous system	KNS42	5
Central nervous system	KNS60	4.8
Central nervous system	KNS81	5
Central nervous system	KS1	4.7
Central nervous system	LN18	6
Central nervous system	LN229	4.6
Central nervous system	M059K	4.5
Central nervous system	MOGGCCM	4.6
Central nervous system	MOGGUVW	4.8
Central nervous system	NMCG1	4.9
Central nervous system	ONS76	4.4
Central nervous system	SF126	5.1
Central nervous system	SF295	4.8
Central nervous system	SNB19	5
Central nervous system	SNU1105	5.2
Central nervous system	SNU201	4.9
Central nervous system	SNU466	5.1
Central nervous system	SNU489	5.7
Central nervous system	SNU626	4.6
Central nervous system	SNU738	4.7
Central nervous system	SW1088	5.2
Central nervous system	SW1783	4.9
Central nervous system	T98G	4.7
Central nervous system	TM31	5.3
Central nervous system	U118MG	6.1
Central nervous system	U138MG	5.1
Central nervous system	U251MG	4.5
Central nervous system	U87MG	4.8
Central nervous system	YH13	5
Central nervous system	YKG1	4.5
Endometrium	AN3CA	7.5
Endometrium	COLO684	5.7
Endometrium	EFE184	4.6
Endometrium	EN	5.6
Endometrium	ESS1	5.1
Endometrium	HEC108	7.2
Endometrium	HEC151	6.6
Endometrium	HEC1A	6.3
Endometrium	HEC1B	5.9
Endometrium	HEC251	4.2
Endometrium	HEC265	6.3
Endometrium	HEC50B	5.1
Endometrium	HEC59	6.3
Endometrium	HEC6	7
Endometrium	ISHIKAWAHERAKLIO02ER	6.5
Endometrium	JHUEM1	6.2
Endometrium	JHUEM2	6.6
Endometrium	JHUEM3	4.3
Endometrium	KLE	4.4
Endometrium	MFE280	5.2
Endometrium	MFE296	6.4
Endometrium	MFE319	5.6
Endometrium	RL952	5.9
Endometrium	SNGM	7.3
Endometrium	SNU1077	4.7
Endometrium	SNU685	6.2
Endometrium	TEN	5.2
Haematopoietic and lymphoid	697	6.9
Haematopoietic and lymphoid	A3KAW	5.7
Haematopoietic and lymphoid	A4FUK	5.7
Haematopoietic and lymphoid	ALLSIL	6.2
Haematopoietic and lymphoid	AML193	5
Haematopoietic and lymphoid	AMO1	6.2
Haematopoietic and lymphoid	BCP1	6.7
Haematopoietic and lymphoid	BDCM	5.4
Haematopoietic and lymphoid	BL41	6.6
Haematopoietic and lymphoid	BL70	6.2
Haematopoietic and lymphoid	BV173	5.2
Haematopoietic and lymphoid	CA46	5.4
Haematopoietic and lymphoid	CI1	5.1
Haematopoietic and lymphoid	CMK115	5.9
Haematopoietic and lymphoid	CMK86	6.3
Haematopoietic and lymphoid	CMK	5.7
Haematopoietic and lymphoid	CMLT1	6.9
Haematopoietic and lymphoid	COLO775	6.3
Haematopoietic and lymphoid	DAUDI	4.4
Haematopoietic and lymphoid	DB	5.8
Haematopoietic and lymphoid	DEL	5.6
Haematopoietic and lymphoid	DND41	6.9
Haematopoietic and lymphoid	DOHH2	6
Haematopoietic and lymphoid	EB1	5.6
Haematopoietic and lymphoid	EB2	5
Haematopoietic and lymphoid	EHEB	6.1
Haematopoietic and lymphoid	EJM	6.7
Haematopoietic and lymphoid	EM2	6.4
Haematopoietic and lymphoid	EOL1	5.4
Haematopoietic and lymphoid	F36P	6.1
Haematopoietic and lymphoid	GA10	6.6
Haematopoietic and lymphoid	GDM1	4.8
Haematopoietic and lymphoid	GRANTA519	5.3
Haematopoietic and lymphoid	HDLM2	5.4
Haematopoietic and lymphoid	HDMYZ	4.4
Haematopoietic and lymphoid	HEL9217	5.8
Haematopoietic and lymphoid	HEL	5.3
Haematopoietic and lymphoid	HH	5.9
Haematopoietic and lymphoid	HL60	6.3
Haematopoietic and lymphoid	HPBALL	6.3
Haematopoietic and lymphoid	HS604T	4.5
Haematopoietic and lymphoid	HS611T	5
Haematopoietic and lymphoid	HS616T	4.6
Haematopoietic and lymphoid	HS751T	4.5
Haematopoietic and lymphoid	HT	6.7
Haematopoietic and lymphoid	HTK	6
Haematopoietic and lymphoid	HUNS1	5
Haematopoietic and lymphoid	HUT102	5.1
Haematopoietic and lymphoid	HUT78	5.3
Haematopoietic and lymphoid	JEKO1	7
Haematopoietic and lymphoid	JK1	5.3
Haematopoietic and lymphoid	JM1	5.2
Haematopoietic and lymphoid	JURKAT	8
Haematopoietic and lymphoid	JURLMK1	5
Haematopoietic and lymphoid	JVM2	5.9
Haematopoietic and lymphoid	JVM3	5.6
Haematopoietic and lymphoid	K562	5.2
Haematopoietic and lymphoid	KARPAS299	4.9
Haematopoietic and lymphoid	KARPAS422	5.7
Haematopoietic and lymphoid	KARPAS620	7.1
Haematopoietic and lymphoid	KASUMI1	4.7
Haematopoietic and lymphoid	KASUMI2	5.8
Haematopoietic and lymphoid	KASUMI6	5.6
Haematopoietic and lymphoid	KCL22	7.3
Haematopoietic and lymphoid	KE37	5.9
Haematopoietic and lymphoid	KE97	5.3
Haematopoietic and lymphoid	KG1	5.8
Haematopoietic and lymphoid	KHM1B	5.3
Haematopoietic and lymphoid	KIJK	5.6
Haematopoietic and lymphoid	KMH2	6.4
Haematopoietic and lymphoid	KMM1	5.9
Haematopoietic and lymphoid	KMS11	5.9
Haematopoietic and lymphoid	KMS12BM	6.8
Haematopoietic and lymphoid	KMS18	5
Haematopoietic and lymphoid	KMS20	5.3
Haematopoietic and lymphoid	KMS21BM	5.9
Haematopoietic and lymphoid	KMS26	5.3
Haematopoietic and lymphoid	KMS27	6
Haematopoietic and lymphoid	KMS28BM	5.6
Haematopoietic and lymphoid	KMS34	6.2
Haematopoietic and lymphoid	KO52	5.6
Haematopoietic and lymphoid	KOPN8	6.4
Haematopoietic and lymphoid	KU812	7.2
Haematopoietic and lymphoid	KYO1	6.4
Haematopoietic and lymphoid	L1236	5.4
Haematopoietic and lymphoid	L363	6.1
Haematopoietic and lymphoid	L428	6.4
Haematopoietic and lymphoid	L540	5.4
Haematopoietic and lymphoid	LAMA84	5.6
Haematopoietic and lymphoid	LOUCY	4.9
Haematopoietic and lymphoid	LP1	5.1
Haematopoietic and lymphoid	M07E	6.7
Haematopoietic and lymphoid	MC116	5.4
Haematopoietic and lymphoid	ME1	6
Haematopoietic and lymphoid	MEC1	4.9
Haematopoietic and lymphoid	MEC2	6.8
Haematopoietic and lymphoid	MEG01	5.2
Haematopoietic and lymphoid	MHHCALL2	6
Haematopoietic and lymphoid	MHHCALL3	5.9
Haematopoietic and lymphoid	MHHCALL4	6.2
Haematopoietic and lymphoid	MINO	6.5
Haematopoietic and lymphoid	MJ	6.6
Haematopoietic and lymphoid	MM1S	6
Haematopoietic and lymphoid	MOLM13	5.6
Haematopoietic and lymphoid	MOLM16	6.8
Haematopoietic and lymphoid	MOLM6	4.9
Haematopoietic and lymphoid	MOLP2	5.2
Haematopoietic and lymphoid	MOLP8	5.4
Haematopoietic and lymphoid	MOLT13	6.1
Haematopoietic and lymphoid	MOLT16	6.5
Haematopoietic and lymphoid	MOLT4	7
Haematopoietic and lymphoid	MONOMAC1	5.6
Haematopoietic and lymphoid	MONOMAC6	6.1
Haematopoietic and lymphoid	MOTN1	5.9
Haematopoietic and lymphoid	MUTZ5	4.7
Haematopoietic and lymphoid	MV411	5.9
Haematopoietic and lymphoid	NALM19	6.1
Haematopoietic and lymphoid	NALM1	5.4
Haematopoietic and lymphoid	NALM6	6.9
Haematopoietic and lymphoid	NAMALWA	6.1
Haematopoietic and lymphoid	NB4	6.8
Haematopoietic and lymphoid	NCIH929	4.9
Haematopoietic and lymphoid	NCO2	5.8
Haematopoietic and lymphoid	NOMO1	6.2
Haematopoietic and lymphoid	NUDHL1	5.4
Haematopoietic and lymphoid	NUDUL1	6.3
Haematopoietic and lymphoid	OCIAML2	5.3
Haematopoietic and lymphoid	OCIAML3	5.6
Haematopoietic and lymphoid	OCIAML5	5.1
Haematopoietic and lymphoid	OCILY10	5.3
Haematopoietic and lymphoid	OCILY19	5.7
Haematopoietic and lymphoid	OCILY3	5
Haematopoietic and lymphoid	OCIM1	6.4
Haematopoietic and lymphoid	OPM2	5.8
Haematopoietic and lymphoid	P12ICHIKAWA	6.1
Haematopoietic and lymphoid	P31FUJ	5.7
Haematopoietic and lymphoid	P3HR1	5
Haematopoietic and lymphoid	PCM6	5.9
Haematopoietic and lymphoid	PEER	6.3
Haematopoietic and lymphoid	PF382	5.5
Haematopoietic and lymphoid	PFEIFFER	6.2
Haematopoietic and lymphoid	PL21	4.9
Haematopoietic and lymphoid	RAJI	5.5
Haematopoietic and lymphoid	RCHACV	6.3
Haematopoietic and lymphoid	REC1	6.6
Haematopoietic and lymphoid	REH	7
Haematopoietic and lymphoid	RI1	6.4
Haematopoietic and lymphoid	RL	5.6
Haematopoietic and lymphoid	RPMI8226	5.6
Haematopoietic and lymphoid	RPMI8402	6.7
Haematopoietic and lymphoid	RS411	5.9
Haematopoietic and lymphoid	SEM	6.6
Haematopoietic and lymphoid	SET2	5.8
Haematopoietic and lymphoid	SIGM5	6
Haematopoietic and lymphoid	SKM1	4.9
Haematopoietic and lymphoid	SKMM2	5
Haematopoietic and lymphoid	SR786	5.6
Haematopoietic and lymphoid	ST486	5.6
Haematopoietic and lymphoid	SUDHL10	5.7
Haematopoietic and lymphoid	SUDHL1	5
Haematopoietic and lymphoid	SUDHL4	5.8
Haematopoietic and lymphoid	SUDHL5	6.3
Haematopoietic and lymphoid	SUDHL6	6.7
Haematopoietic and lymphoid	SUDHL8	5.6
Haematopoietic and lymphoid	SUPB15	5.6
Haematopoietic and lymphoid	SUPHD1	6
Haematopoietic and lymphoid	SUPM2	4.7
Haematopoietic and lymphoid	SUPT11	6.2
Haematopoietic and lymphoid	SUPT1	6.7
Haematopoietic and lymphoid	TALL1	5.7
Haematopoietic and lymphoid	TF1	6.1
Haematopoietic and lymphoid	THP1	5.5
Haematopoietic and lymphoid	TO175T	4.5
Haematopoietic and lymphoid	TOLEDO	5.7
Haematopoietic and lymphoid	U266B1	5.7
Haematopoietic and lymphoid	U937	5
Haematopoietic and lymphoid	UT7	5.1
Haematopoietic and lymphoid	WSUDLCL2	5.7
Kidney	769P	5.5
Kidney	786O	5.8
Kidney	A498	4.7
Kidney	A704	4.3
Kidney	ACHN	4.2
Kidney	BFTC909	5
Kidney	CAKI1	5.1
Kidney	CAKI2	4.5
Kidney	CAL54	4.7
Kidney	KMRC1	4.8
Kidney	KMRC20	5
Kidney	KMRC2	5.1
Kidney	KMRC3	4.6
Kidney	OSRC2	5.1
Kidney	RCC10RGB	4.4
Kidney	SNU1272	4.7
Kidney	SNU349	6.6
Kidney	TUHR10TKB	5.7
Kidney	TUHR14TKB	4.5
Kidney	TUHR4TKB	4.9
Kidney	VMRCRCW	5
Kidney	VMRCRCZ	4.5
Large intestine	C2BBE1	4.5
Large intestine	CCK81	5.8
Large intestine	CL11	6.1
Large intestine	CL14	5.3
Large intestine	CL34	7.8
Large intestine	CL40	5.6
Large intestine	COLO205	4.7
Large intestine	COLO320	5.3
Large intestine	COLO678	5.4
Large intestine	CW2	7.6
Large intestine	DLD1	5.8
Large intestine	GP2D	7.1
Large intestine	HCC56	4.7
Large intestine	HCT116	6.8
Large intestine	HCT15	5.1
Large intestine	HS675T	4.3
Large intestine	HS698T	4.4
Large intestine	HT115	5
Large intestine	HT29	6
Large intestine	HT55	4.7
Large intestine	KM12	6
Large intestine	LOVO	6.2
Large intestine	LS1034	5.1
Large intestine	LS123	5
Large intestine	LS180	6.5
Large intestine	LS411N	6.3
Large intestine	LS513	4.4
Large intestine	MDST8	5.4
Large intestine	NCIH508	4.5
Large intestine	NCIH716	4.8
Large intestine	NCIH747	5.1
Large intestine	OUMS23	4.7
Large intestine	RCM1	4.5
Large intestine	RKO	5.6
Large intestine	SKCO1	5
Large intestine	SNU1040	5.2
Large intestine	SNU1197	4.9
Large intestine	SNU175	6.9
Large intestine	SNU283	5.7
Large intestine	SNU407	7
Large intestine	SNU503	4.7
Large intestine	SNU61	5.4
Large intestine	SNU81	5.8
Large intestine	SNUC1	5.1
Large intestine	SNUC2A	6.4
Large intestine	SNUC4	7.6
Large intestine	SNUC5	6.6
Large intestine	SW1116	5
Large intestine	SW1417	4.9
Large intestine	SW1463	5.1
Large intestine	SW403	5.4
Large intestine	SW480	5
Large intestine	SW48	6
Large intestine	SW620	5.9
Large intestine	SW837	4.5
Large intestine	SW948	5.1
Large intestine	T84	5.5
Liver	ALEXANDERCELLS	5
Liver	C3A	4.6
Liver	HEP3B217	5.2
Liver	HEPG2	4.9
Liver	HLE	5.4
Liver	HLF	4.8
Liver	HUH1	5.4
Liver	HUH6	4.6
Liver	HUH7	5.1
Liver	JHH1	4.4
Liver	JHH2	5.1
Liver	JHH4	4.5
Liver	JHH5	5.3
Liver	JHH6	4.5
Liver	JHH7	4.9
Liver	LI7	5.4
Liver	PLCPRF5	4.9
Liver	SKHEP1	4.8
Liver	SNU182	5.1
Liver	SNU387	4.4
Liver	SNU398	5.5
Liver	SNU423	5.4
Liver	SNU449	4.7
Liver	SNU475	4.9
Liver	SNU761	4.5
Liver	SNU878	4.4
Liver	SNU886	6
Lung	A549	5.1
Lung	ABC1	5
Lung	BEN	5
Lung	CAL12T	5.7
Lung	CALU1	5.3
Lung	CALU3	5.1
Lung	CALU6	4.8
Lung	CHAGOK1	4.5
Lung	COLO668	5.3
Lung	COLO699	4.5
Lung	CORL105	4.9
Lung	CORL23	5.5
Lung	CORL24	4.2
Lung	CORL279	5.1
Lung	CORL311	5.8
Lung	CORL47	4.5
Lung	CORL51	4.9
Lung	CORL88	5.6
Lung	CORL95	4.9
Lung	CPCN	5
Lung	DMS114	5.1
Lung	DMS153	4.4
Lung	DMS273	4.9
Lung	DMS454	4.1
Lung	DMS53	4.8
Lung	DMS79	5
Lung	DV90	5.9
Lung	EBC1	5.5
Lung	EPLC272H	5.2
Lung	HARA	5.9
Lung	HCC1171	4.7
Lung	HCC1195	5.4
Lung	HCC15	5
Lung	HCC2279	5.1
Lung	HCC2935	4.8
Lung	HCC33	4.9
Lung	HCC366	4.6
Lung	HCC4006	5.4
Lung	HCC44	5
Lung	HCC78	4.7
Lung	HCC827	5.2
Lung	HCC95	4.4
Lung	HLC1	5
Lung	HLFA	4.5
Lung	HS229T	4.6
Lung	HS618T	4.8
Lung	IALM	4.9
Lung	KNS62	5.5
Lung	LC1F	5.1
Lung	LC1SQSF	4.7
Lung	LCLC103H	5.8
Lung	LCLC97TM1	5.3
Lung	LK2	6.1
Lung	LOUNH91	4.9
Lung	LU65	4.9
Lung	LU99	5.2
Lung	LUDLU1	5.3
Lung	LXF289	4.8
Lung	MORCPR	5
Lung	NCIH1048	6
Lung	NCIH1092	4.8
Lung	NCIH1105	4.6
Lung	NCIH1155	5.2
Lung	NCIH1184	5
Lung	NCIH1299	5
Lung	NCIH1339	4.7
Lung	NCIH1341	4.9
Lung	NCIH1355	5.5
Lung	NCIH1373	4.7
Lung	NCIH1385	4.7
Lung	NCIH1395	4.7
Lung	NCIH1435	5.4
Lung	NCIH1436	4.7
Lung	NCIH1437	4.4
Lung	NCIH146	5
Lung	NCIH1563	4.4
Lung	NCIH1568	5.3
Lung	NCIH1573	4.4
Lung	NCIH1581	5.4
Lung	NCIH1618	5
Lung	NCIH1623	4.7
Lung	NCIH1648	4.4
Lung	NCIH1650	4.6
Lung	NCIH1651	4.3
Lung	NCIH1666	5.1
Lung	NCIH1693	4.9
Lung	NCIH1694	4.5
Lung	NCIH1703	5
Lung	NCIH1734	4.7
Lung	NCIH1755	5.3
Lung	NCIH1781	4.8
Lung	NCIH1792	5
Lung	NCIH1793	4.9
Lung	NCIH1836	5.1
Lung	NCIH1838	4.3
Lung	NCIH1869	5.2
Lung	NCIH1876	4.3
Lung	NCIH1915	5
Lung	NCIH1930	5
Lung	NCIH1944	5.1
Lung	NCIH1963	4.9
Lung	NCIH196	4.8
Lung	NCIH1975	4.8
Lung	NCIH2009	5.6
Lung	NCIH2023	4.3
Lung	NCIH2029	5
Lung	NCIH2030	5.1
Lung	NCIH2066	4.8
Lung	NCIH2081	4.4
Lung	NCIH2085	4.5
Lung	NCIH2087	4.2
Lung	NCIH209	5.2
Lung	NCIH2106	7
Lung	NCIH2110	4.7
Lung	NCIH211	5.4
Lung	NCIH2122	4.3
Lung	NCIH2126	4.8
Lung	NCIH2141	5
Lung	NCIH2170	5.9
Lung	NCIH2171	5.2
Lung	NCIH2172	4.8
Lung	NCIH2196	4.6
Lung	NCIH2227	4.5
Lung	NCIH2228	4.2
Lung	NCIH226	5
Lung	NCIH2286	5.1
Lung	NCIH2291	4.2
Lung	NCIH2342	4.8
Lung	NCIH2347	5.1
Lung	NCIH23	5.2
Lung	NCIH2405	5.3
Lung	NCIH2444	4.4
Lung	NCIH292	6.5
Lung	NCIH322	4.5
Lung	NCIH3255	5.5
Lung	NCIH358	5.5
Lung	NCIH441	4.9
Lung	NCIH446	5.5
Lung	NCIH460	4.7
Lung	NCIH510	4.5
Lung	NCIH520	5.6
Lung	NCIH522	4.9
Lung	NCIH524	5.1
Lung	NCIH526	5.9
Lung	NCIH596	4.7
Lung	NCIH647	4.7
Lung	NCIH650	4.7
Lung	NCIH661	4.7
Lung	NCIH69	5.2
Lung	NCIH727	6
Lung	NCIH810	4.5
Lung	NCIH82	5.2
Lung	NCIH838	4.7
Lung	NCIH841	5.9
Lung	NCIH854	5
Lung	NCIH889	4.8
Lung	PC14	5
Lung	RERFLCAD1	4.9
Lung	RERFLCAD2	4.5
Lung	RERFLCAI	5.4
Lung	RERFLCKJ	3.8
Lung	RERFLCMS	4.5
Lung	RERFLCSQ1	5
Lung	SBC5	4.8
Lung	SCLC21H	5.2
Lung	SHP77	5.7
Lung	SKLU1	5.1
Lung	SKMES1	4.7
Lung	SQ1	5.9
Lung	SW1271	5.6
Lung	SW1573	5.2
Lung	SW900	5.2
Lung	VMRCLCD	5.2
Lung	VMRCLCP	4.8
Oesophagus	COLO680N	4.7
Oesophagus	ECGI10	4.5
Oesophagus	KYSE140	4.8
Oesophagus	KYSE150	6
Oesophagus	KYSE180	5.2
Oesophagus	KYSE270	5.1
Oesophagus	KYSE30	5.2
Oesophagus	KYSE410	4.7
Oesophagus	KYSE450	5.8
Oesophagus	KYSE510	5.5
Oesophagus	KYSE520	5.3
Oesophagus	KYSE70	4.5
Oesophagus	OE19	5.1
Oesophagus	OE33	4.1
Oesophagus	TE10	5.9
Oesophagus	TE11	5.5
Oesophagus	TE14	5.8
Oesophagus	TE15	5.2
Oesophagus	TE1	4.3
Oesophagus	TE4	6.2
Oesophagus	TE5	5.6
Oesophagus	TE6	4.7
Oesophagus	TE8	4.6
Oesophagus	TE9	4.5
Oesophagus	TT	4.3
Ovary	59M	5.2
Ovary	A2780	5.2
Ovary	CAOV3	5.6
Ovary	CAOV4	4.3
Ovary	COLO704	6.1
Ovary	COV318	5
Ovary	COV362	4.5
Ovary	COV434	4.9
Ovary	COV504	4.8
Ovary	COV644	4.8
Ovary	EFO21	5.1
Ovary	EFO27	5.9
Ovary	ES2	5.4
Ovary	FUOV1	4.7
Ovary	HEYA8	5.1
Ovary	HS571T	4.3
Ovary	IGROV1	7.4
Ovary	JHOC5	5
Ovary	JHOM1	4.7
Ovary	JHOM2B	5.4
Ovary	JHOS2	4.2
Ovary	JHOS4	5
Ovary	KURAMOCHI	5.8
Ovary	MCAS	5.4
Ovary	NIHOVCAR3	4.7
Ovary	OAW28	4.6
Ovary	OAW42	5.2
Ovary	OC314	6.2
Ovary	OC316	6.8
Ovary	ONCODG1	5
Ovary	OV56	4.2
Ovary	OV7	5.3
Ovary	OV90	4.9
Ovary	OVCAR4	4.8
Ovary	OVCAR8	4.6
Ovary	OVISE	4.6
Ovary	OVK18	7.6
Ovary	OVKATE	4.4
Ovary	OVMANA	4.6
Ovary	OVSAHO	5.3
Ovary	OVTOKO	4.9
Ovary	RMGI	4.8
Ovary	RMUGS	4.9
Ovary	SKOV3	5
Ovary	SNU119	5.2
Ovary	SNU840	5.7
Ovary	SNU8	5.6
Ovary	TOV112D	5.6
Ovary	TOV21G	5.4
Ovary	TYKNU	5.8
Pancreas	ASPC1	5
Pancreas	BXPC3	6.2
Pancreas	CAPAN1	4.7
Pancreas	CAPAN2	4.8
Pancreas	CFPAC1	4.4
Pancreas	DANG	5.6
Pancreas	HPAC	5.5
Pancreas	HPAFII	5.2
Pancreas	HS766T	5.3
Pancreas	HUPT3	4.8
Pancreas	HUPT4	5.5
Pancreas	KCIMOH1	5.3
Pancreas	KLM1	6.9
Pancreas	KP2	5.3
Pancreas	KP3	5.8
Pancreas	KP4	5.8
Pancreas	L33	4.5
Pancreas	MIAPACA2	5.2
Pancreas	PANC0203	4.2
Pancreas	PANC0213	4.2
Pancreas	PANC0327	4.8
Pancreas	PANC0403	4.7
Pancreas	PANC0504	4.5
Pancreas	PANC0813	5.5
Pancreas	PANC1005	5.3
Pancreas	PANC1	5
Pancreas	PATU8902	4.8
Pancreas	PATU8988S	5.6
Pancreas	PATU8988T	6.1
Pancreas	PK1	5.3
Pancreas	PK45H	4.9
Pancreas	PK59	4.7
Pancreas	PL45	4.8
Pancreas	PSN1	4.8
Pancreas	QGP1	4.8
Pancreas	SNU213	5.4
Pancreas	SNU324	7.3
Pancreas	SNU410	4.8
Pancreas	SU8686	4.6
Pancreas	SUIT2	4.4
Pancreas	SW1990	5.4
Pancreas	T3M4	4.7
Pancreas	TCCPAN2	5.5
Pancreas	YAPC	4.8
Pleura	ACCMESO1	4.7
Pleura	DM3	4.7
Pleura	ISTMES1	4.7
Pleura	ISTMES2	4.9
Pleura	JL1	5.3
Pleura	MPP89	4.7
Pleura	MSTO211H	4.8
Pleura	NCIH2052	4.9
Pleura	NCIH2452	5
Pleura	NCIH28	4.6
Prostate	22RV1	6.2
Prostate	DU145	5.9
Prostate	LNCAPCLONEFGC	5.9
Prostate	MDAPCA2B	6.3
Prostate	NCIH660	4.4
Prostate	PC3	5.2
Prostate	VCAP	4.9
Salivary gland	A253	4.8
Salivary gland	YD15	5.9
Skin	A101D	4.9
Skin	A2058	6.1
Skin	A375	6
Skin	C32	4.8
Skin	CHL1	5.3
Skin	CJM	6
Skin	COLO679	5.1
Skin	COLO741	4.8
Skin	COLO783	4.8
Skin	COLO792	4.2
Skin	COLO800	4.9
Skin	COLO818	4.7
Skin	COLO829	5
Skin	COLO849	4.8
Skin	G361	4.7
Skin	GRM	6.9
Skin	HMCB	5.2
Skin	HS294T	5.1
Skin	HS600T	4.7
Skin	HS688AT	4.5
Skin	HS695T	4.6
Skin	HS839T	4.4
Skin	HS852T	4.6
Skin	HS895T	4.7
Skin	HS934T	5.2
Skin	HS936T	4.1
Skin	HS939T	4.7
Skin	HS940T	4.6
Skin	HS944T	5
Skin	HT144	4.3
Skin	IGR1	4.7
Skin	IGR37	4.9
Skin	IGR39	4.5
Skin	IPC298	4.9
Skin	K029AX	4.7
Skin	LOXIMVI	5.9
Skin	MALME3M	4.5
Skin	MDAMB435S	4.5
Skin	MELHO	4.8
Skin	MELJUSO	4.9
Skin	MEWO	4.7
Skin	RPMI7951	5
Skin	RVH421	4.7
Skin	SH4	4.7
Skin	SKMEL1	4.4
Skin	SKMEL24	4.6
Skin	SKMEL28	4.6
Skin	SKMEL2	4.3
Skin	SKMEL30	6
Skin	SKMEL31	4.1
Skin	SKMEL3	5
Skin	SKMEL5	4.9
Skin	UACC257	5.2
Skin	UACC62	4.7
Skin	WM115	4.5
Skin	WM1799	4.6
Skin	WM2664	4.6
Skin	WM793	4.5
Skin	WM88	4.9
Skin	WM983B	4.5
Small intestine	HUTU80	4.9
Soft tissue	A204	4.9
Soft tissue	G401	5.6
Soft tissue	G402	4.9
Soft tissue	GCT	5.4
Soft tissue	HS729	5.1
Soft tissue	HT1080	5.2
Soft tissue	KYM1	5.3
Soft tissue	MESSA	5.8
Soft tissue	RD	4.6
Soft tissue	RH30	6.6
Soft tissue	RH41	5.1
Soft tissue	RKN	4.6
Soft tissue	S117	5.5
Soft tissue	SJRH30	4.9
Soft tissue	SKLMS1	4.7
Soft tissue	SKUT1	6.2
Soft tissue	TE125T	4.6
Soft tissue	TE159T	4.4
Soft tissue	TE441T	6.6
Soft tissue	TE617T	5.2
Stomach	2313287	7.9
Stomach	AGS	5.1
Stomach	AZ521	5.5
Stomach	ECC10	4.9
Stomach	ECC12	4.6
Stomach	FU97	5.4
Stomach	GCIY	5.1
Stomach	GSS	5.1
Stomach	GSU	5.4
Stomach	HGC27	5.8
Stomach	HS746T	5.4
Stomach	HUG1N	6
Stomach	IM95	7.1
Stomach	KATOIII	5.4
Stomach	KE39	5.3
Stomach	LMSU	5.5
Stomach	MKN1	5
Stomach	MKN45	6
Stomach	MKN74	5
Stomach	MKN7	4.7
Stomach	NCCSTCK140	5.6
Stomach	NCIN87	5.2
Stomach	NUGC2	4.9
Stomach	NUGC3	6.5
Stomach	NUGC4	5.2
Stomach	OCUM1	5.1
Stomach	RERFGC1B	4.6
Stomach	SH10TC	5.6
Stomach	SNU16	5.9
Stomach	SNU1	6.8
Stomach	SNU216	5.7
Stomach	SNU520	8.3
Stomach	SNU5	5.4
Stomach	SNU601	6.8
Stomach	SNU620	5.3
Stomach	SNU668	5.7
Stomach	SNU719	5.2
Stomach	TGBC11TKB	6.8
Thyroid	8305C	5.3
Thyroid	8505C	6.5
Thyroid	BCPAP	5.7
Thyroid	BHT101	4.8
Thyroid	CAL62	5.9
Thyroid	CGTHW1	4.7
Thyroid	FTC133	5.3
Thyroid	FTC238	4.3
Thyroid	ML1	4.7
Thyroid	SW579	5.1
Thyroid	TT2609C02	5.5
Thyroid	TT	5
Upper aerodigestive tract	BHY	4.8
Upper aerodigestive tract	BICR16	5
Upper aerodigestive tract	BICR18	4.8
Upper aerodigestive tract	BICR22	4.2
Upper aerodigestive tract	BICR31	4.3
Upper aerodigestive tract	BICR56	4.5
Upper aerodigestive tract	BICR6	4.7
Upper aerodigestive tract	CAL27	5
Upper aerodigestive tract	CAL33	5.6
Upper aerodigestive tract	DETROIT562	6.8
Upper aerodigestive tract	FADU	4.8
Upper aerodigestive tract	HS840T	4.7
Upper aerodigestive tract	HSC2	5.2
Upper aerodigestive tract	HSC3	5.4
Upper aerodigestive tract	HSC4	4.9
Upper aerodigestive tract	PECAPJ15	4.6
Upper aerodigestive tract	PECAPJ34CLONEC12	5.5
Upper aerodigestive tract	PECAPJ41CLONED2	5.8
Upper aerodigestive tract	PECAPJ49	5
Upper aerodigestive tract	SCC15	5.2
Upper aerodigestive tract	SCC25	5.3
Upper aerodigestive tract	SCC4	5.2
Upper aerodigestive tract	SCC9	4.5
Upper aerodigestive tract	SNU1076	5.7
Upper aerodigestive tract	SNU1214	5.3
Upper aerodigestive tract	SNU46	5.5
Upper aerodigestive tract	SNU899	6
Upper aerodigestive tract	YD10B	5.2
Upper aerodigestive tract	YD38	5.7
Upper aerodigestive tract	YD8	5
Urinary tract	5637	4.9
Urinary tract	639V	8
Urinary tract	647V	6.1
Urinary tract	BC3C	5.7
Urinary tract	BFTC905	6.2
Urinary tract	CAL29	5.5
Urinary tract	HS172T	4.4
Urinary tract	HT1197	5
Urinary tract	HT1376	5.4
Urinary tract	J82	5.8
Urinary tract	JMSU1	6.5
Urinary tract	KMBC2	5.5
Urinary tract	KU1919	5.2
Urinary tract	RT11284	5.2
Urinary tract	RT112	5.9
Urinary tract	RT4	5.6
Urinary tract	SCABER	4.7
Urinary tract	SW1710	4.5
Urinary tract	SW780	4.9
Urinary tract	T24	5.8
Urinary tract	TCCSUP	7.3
Urinary tract	UMUC1	5.9
Urinary tract	UMUC3	5.1
Urinary tract	VMCUB1	5.8

> The Human Protein Atlas (HPA)

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Tissue	Expression Level (TPM)
Adipose tissue	47.8
Adrenal gland	37.2
Appendix	63.7
Bone marrow	37.6
Breast	38.3
Cerebral cortex	39.3
Cervix, uterine	49.5
Colon	40.3
Duodenum	32
Endometrium	54.4
Epididymis	34.3
Esophagus	65.6
Fallopian tube	46.7
Gallbladder	51.4
Heart muscle	15.7
Kidney	21.1
Liver	14.7
Lung	50.1
Lymph node	82.1
Ovary	46.1
Pancreas	4.5
Parathyroid gland	60.2
Placenta	55.6
Prostate	49.6
Rectum	52.9
Salivary gland	11.8
Seminal vesicle	50.7
Skeletal muscle	4.6
Skin	88.6
Small intestine	34.2
Smooth muscle	63.6
Spleen	72.7
Stomach	28.6
Testis	54.8
Thyroid gland	34.3
Tonsil	86.7
Urinary bladder	47.1

> Text Mining based Expression

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PMID	Expression	Cancer	Evidence
12705869	Overexpression	Glioma	miR-548b was underexpressed in human glioma tissues and cell lines. Re-expression of miR-548b significantly inhibited the proliferation and colony formation of U87 and U373 glioma cells. Enforced expression of miR-548b significantly impaired the invasiveness of glioma cells. Notably, metastasis tumor-associated protein-2 (MTA2) was a direct target of miR-548b. Overexpression of miR-548b negatively regulated endogenous MTA2 expression in U87 cells.
27051300	Overexpression	Nasopharyngeal Carcinoma	MTA2 was upregulated in NPC tissues and three NPC cell lines detected (CNE1, CNE2, and HNE1).
26722504	Overexpression	Hepatocellular Carcinoma	We found MTA2 and Ki-67 were both increased in HCC tissues than those in adjacent tissues and nuclear MTA2 was associated with Ki-67 (P = 0.019).
26261611	Overexpression	Colorectal Carcinoma	Expression of MTA2 in CRC tissues were notably higher than their adjacent tissues (P < 0.001) and showed significant positive correlation with tumor grade (r(2) > 0, P < 0.01).
26254420	Underexpression	Pleural Malignant Mesothelioma	In the Gordon Mesothelioma Study, 34 of them were assessed out of which SUMO1, UBC3, KIAA0101, HDAC2, DAXX, RBBP4, BBS1, NONO, RBBP7, HTRA2, and STUB1 were significantly overexpressed whereas TRAF6 and MTA2 were significantly underexpressed in MPM patients (network 2).
25969565	Overexpression	Lung Carcinoma	The patient samples collected in our hospital show that metastasis-associated protein 2 was expressed in aggressive lung cancer cells, and its higher expression is correlated with poor prognosis
24468085	Overexpression	Colon Carcinoma	MTA2 is a member of metastasis associated family, which is highly expressed in several solid tumors and associated with tumor cells migration and invasion.
23400716	Overexpression	Pancreatic Ductal Adenocarcinoma	We found that MTA2 mRNA and protein expression levels were both significantly upregulated in PDA lesions compared with adjacent noncancerous tissues.
23158992	Overexpression	Gastric Carcinoma	The expression of MTA2 protein was significantly higher in primary lesions of the gastric cancer than that in non-cancerous mucosa by IHC (31.3% vs 12.0%, P < 0.01).
22585429	Overexpression	non-Small Cell Lung Carcinoma	Nuclear MTA2 expression was detected in 148 cases of NSCLC (66.4%), and was correlated with advanced TNM stages (p=0.023), tumor size (p=0.036), and lymph node metastasis (p=0.004).
20704817	Overexpression	non-Small Cell Lung Carcinoma	The positive rate of MTA2 was 58.18% (64/110) in 110 NSCLC cases.
19702911	Overexpression	Hepatocellular Carcinoma	Notably, the MTA2 expression level strongly increased depending on the size and differentiation of HCC.
16961294	Overexpression	Ovarian Carcinoma	The expression of MTA2 mRNA and protein was detected in all of 4 cell lines of ovarian epithelial cancer. The expression of MTA2 mRNA and protein was higher in strong migration cell lines than in weak migration ones. In borderline and malignant ovarian tissues tested, MTA2 staining was dramatically stronger than in normal and benign tissues (P < 0.01). The expression levels in malignant ovarian tissues were significantly higher than that in borderline epithelial ovarian tissues (P < 0.01).
28502558	Overexpression	Gastric Carcinoma	The present study detected metastasis-associated protein 2 (MTA2) and Histone deacetylases 1 (HDAC1) proteins that were overexpressed in gastric cancer tissues compared with that in adjacent gastric tissue.
27807324	Overexpression	Cervical Carcinoma	Theexpression of MTA2 mRNA innormal cervical tissue, CIN and cervical squamous carcinomas tissues was0.437±0.028, 0.737±0.102 and 1.172±0.068, respectively. The positive rate was associated with FIGO stage and lymph node metastasis, whereas there was no correlation with the age of patients or the degree of tumor differentiation. The result of survival analysis showed poor overall survival time in the patients with high expression of MTA2.

Summary
Symbol	MTA2
Name	metastasis associated 1 family member 2
Aliases	MTA1-L1; MTA1L1; metastasis associated gene family, member 2; PID; MTA1-L1 protein; metastasis -associated g ......
Location	11q12.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

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Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.464	5.89e-23	20.8	56.4	22.8	Neutral
BRCA	Breast invasive carcinoma	1075	0.576	5.02e-96	21.5	61.2	17.3	Neutral
CESC	Cervical and endocervical cancers	292	0.426	2.61e-14	22.6	68.8	8.6	Neutral
COAD	Colon adenocarcinoma	449	0.388	1.39e-17	14.5	75.3	10.2	Neutral
ESCA	Esophageal carcinoma	183	0.523	3.24e-14	18	55.7	26.2	Neutral
GBM	Glioblastoma multiforme	147	0.335	3.31e-05	19	78.9	2	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.574	2.44e-46	15	61.5	23.5	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.108	0.013	3.6	90.1	6.3	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.128	0.0294	5.6	91.3	3.1	Neutral
LAML	Acute Myeloid Leukemia	166	0.312	4.19e-05	0	96.4	3.6	Neutral
LGG	Brain Lower Grade Glioma	513	0.277	1.85e-10	4.7	86.2	9.2	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.426	1.89e-17	17.6	76.1	6.3	Neutral
LUAD	Lung adenocarcinoma	512	0.507	8.17e-35	15.6	59.2	25.2	Neutral
LUSC	Lung squamous cell carcinoma	498	0.483	1.67e-30	20.5	57	22.5	Neutral
OV	Ovarian serous cystadenocarcinoma	300	0.571	2.35e-27	23	49.7	27.3	Neutral
PAAD	Pancreatic adenocarcinoma	177	0.341	3.46e-06	9	83.1	7.9	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.498	1.51e-11	21.6	75.3	3.1	Neutral
PRAD	Prostate adenocarcinoma	491	0.24	7.75e-08	1.8	91.6	6.5	Neutral
READ	Rectum adenocarcinoma	164	0.444	2.7e-09	22.6	63.4	14	Neutral
SARC	Sarcoma	255	0.498	2.3e-17	22	64.7	13.3	Neutral
SKCM	Skin Cutaneous Melanoma	367	0.595	1.42e-36	34.1	54	12	Loss
STAD	Stomach adenocarcinoma	413	0.352	1.7e-13	11.6	71.9	16.5	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.598	6.45e-16	76	21.3	2.7	Loss
THCA	Thyroid carcinoma	497	0.143	0.00137	1.6	97.4	1	Neutral
THYM	Thymoma	119	0.17	0.0639	5.9	93.3	0.8	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.399	6.02e-22	8.2	80.6	11.2	Neutral

Summary
Symbol	MTA2
Name	metastasis associated 1 family member 2
Aliases	MTA1-L1; MTA1L1; metastasis associated gene family, member 2; PID; MTA1-L1 protein; metastasis -associated g ......
Location	11q12.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

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Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.293	8.35e-10	17	408	-0.073	0.0989	NS/NA
BRCA	Breast invasive carcinoma	-0.2	3.26e-09	83	785	0.001	0.104	NS/NA
CESC	Cervical and endocervical cancers	-0.116	0.041	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.117	0.0372	19	297	-0.003	0.673	NS/NA
ESCA	Esophageal carcinoma	-0.171	0.0172	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.284	0.022	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.083	0.0539	20	522	0.069	0.00737	NS/NA
KIRC	Kidney renal clear cell carcinoma	0.025	0.648	24	319	0.001	0.00696	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.038	0.513	23	275	0.004	0.742	NS/NA
LAML	Acute Myeloid Leukemia	-0.191	0.0126	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.08	0.066	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.131	0.00761	41	373	0.001	0.273	NS/NA
LUAD	Lung adenocarcinoma	-0.14	0.00221	21	456	0.002	0.493	NS/NA
LUSC	Lung squamous cell carcinoma	-0.217	2.24e-05	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.25	0.521	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.222	0.00261	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.238	0.00105	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.103	0.0172	35	498	0.002	0.00578	NS/NA
READ	Rectum adenocarcinoma	-0.214	0.0321	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.089	0.15	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.253	2.79e-08	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.062	0.234	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.243	0.00228	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.105	0.0126	50	509	-0.001	0.614	NS/NA
THYM	Thymoma	-0.124	0.172	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.078	0.0945	34	431	-0.003	0.252	NS/NA

Summary
Symbol	MTA2
Name	metastasis associated 1 family member 2
Aliases	MTA1-L1; MTA1L1; metastasis associated gene family, member 2; PID; MTA1-L1 protein; metastasis -associated g ......
Location	11q12.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	3	High
Appendix	3	High
Bone marrow	3	High
Breast	3	High
Bronchus	3	High
Caudate	3	High
Cerebellum	3	High
Cerebral cortex	3	High
Cervix, uterine	3	High
Colon	3	High
Duodenum	3	High
Endometrium	3	High
Epididymis	3	High
Esophagus	3	High
Fallopian tube	3	High
Gallbladder	3	High
Heart muscle	3	High
Hippocampus	3	High
Kidney	3	High
Liver	3	High
Lung	3	High
Lymph node	3	High
Nasopharynx	3	High
Oral mucosa	3	High
Ovary	3	High
Pancreas	3	High
Parathyroid gland	3	High
Placenta	3	High
Prostate	3	High
Rectum	3	High
Salivary gland	3	High
Seminal vesicle	3	High
Skeletal muscle	3	High
Skin	3	High
Small intestine	3	High
Smooth muscle	3	High
Soft tissue	3	High
Spleen	3	High
Stomach	3	High
Testis	3	High
Thyroid gland	3	High
Tonsil	3	High
Urinary bladder	3	High
Vagina	3	High

Summary
Symbol	MTA2
Name	metastasis associated 1 family member 2
Aliases	MTA1-L1; MTA1L1; metastasis associated gene family, member 2; PID; MTA1-L1 protein; metastasis -associated g ......
Location	11q12.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.0455	Significant	24476821
BRCA	Breast invasive carcinoma	521	4.83e-17	Significant	23000897
COAD	Colon adenocarcinoma	149	0.6	NS	22810696
GBM	Glioblastoma multiforme	157	0.00199	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	5.03e-06	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.614	NS	26536169
LGG	Brain Lower Grade Glioma	513	1.06e-15	Significant	26824661
LUAD	Lung adenocarcinoma	230	0.000333	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	0.0446	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.369	NS	21720365
PRAD	Prostate adenocarcinoma	333	0.000141	Significant	26544944
READ	Rectum adenocarcinoma	67	0.758	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.134	NS	26091043
STAD	Stomach adenocarcinoma	277	6.39e-10	Significant	25079317
THCA	Thyroid carcinoma	391	1.91e-05	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	3.68e-06	Significant	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	0.934	0.76	NS
BRCA	Breast invasive carcinoma	1079	0.694	0.111	NS
CESC	Cervical and endocervical cancers	291	0.71	0.313	NS
COAD	Colon adenocarcinoma	439	1.033	0.91	NS
ESCA	Esophageal carcinoma	184	0.731	0.371	NS
GBM	Glioblastoma multiforme	158	0.786	0.341	NS
HNSC	Head and Neck squamous cell carcinoma	518	0.856	0.445	NS
KIRC	Kidney renal clear cell carcinoma	531	1.937	0.00221	Shorter
KIRP	Kidney renal papillary cell carcinoma	287	1.262	0.552	NS
LAML	Acute Myeloid Leukemia	149	2.119	0.0106	Shorter
LGG	Brain Lower Grade Glioma	511	0.83	0.426	NS
LIHC	Liver hepatocellular carcinoma	365	1.429	0.139	NS
LUAD	Lung adenocarcinoma	502	1.611	0.0224	Shorter
LUSC	Lung squamous cell carcinoma	494	0.779	0.221	NS
OV	Ovarian serous cystadenocarcinoma	303	0.771	0.211	NS
PAAD	Pancreatic adenocarcinoma	177	1.483	0.187	NS
PCPG	Pheochromocytoma and Paraganglioma	179	763308923.783	0.0523	NS
PRAD	Prostate adenocarcinoma	497	0.842	0.834	NS
READ	Rectum adenocarcinoma	159	0.781	0.676	NS
SARC	Sarcoma	259	1.328	0.297	NS
SKCM	Skin Cutaneous Melanoma	459	1.01	0.958	NS
STAD	Stomach adenocarcinoma	388	0.491	0.00198	Longer
TGCT	Testicular Germ Cell Tumors	134	554428970.504	0.335	NS
THCA	Thyroid carcinoma	500	1.183	0.82	NS
THYM	Thymoma	119	0.511	0.456	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	0.848	0.592	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	-0.121	0.0151	Lower
BRCA	Breast invasive carcinoma	1071	-0.015	0.634	NS
CESC	Cervical and endocervical cancers	167	-0.102	0.188	NS
COAD	Colon adenocarcinoma	445	-0.041	0.39	NS
ESCA	Esophageal carcinoma	162	-0.186	0.0181	Lower
HNSC	Head and Neck squamous cell carcinoma	448	-0.094	0.0474	Lower
KIRC	Kidney renal clear cell carcinoma	531	0.161	0.000198	Higher
KIRP	Kidney renal papillary cell carcinoma	260	0.047	0.451	NS
LIHC	Liver hepatocellular carcinoma	347	0.05	0.353	NS
LUAD	Lung adenocarcinoma	507	0.097	0.0287	Higher
LUSC	Lung squamous cell carcinoma	497	-0.026	0.568	NS
OV	Ovarian serous cystadenocarcinoma	302	0.018	0.759	NS
PAAD	Pancreatic adenocarcinoma	176	0.09	0.236	NS
READ	Rectum adenocarcinoma	156	0.036	0.652	NS
SKCM	Skin Cutaneous Melanoma	410	-0.125	0.0115	Lower
STAD	Stomach adenocarcinoma	392	-0.143	0.00461	Lower
TGCT	Testicular Germ Cell Tumors	81	0.08	0.479	NS
THCA	Thyroid carcinoma	499	0.043	0.339	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	-0.014	0.756	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	-0.004	0.942	NS
HNSC	Head and Neck squamous cell carcinoma	498	0.13	0.00362	Higher
KIRC	Kidney renal clear cell carcinoma	525	0.173	6.5e-05	Higher
LGG	Brain Lower Grade Glioma	514	0.1	0.023	Higher
LIHC	Liver hepatocellular carcinoma	366	0.115	0.0272	Higher
OV	Ovarian serous cystadenocarcinoma	296	0.042	0.474	NS
PAAD	Pancreatic adenocarcinoma	176	0.073	0.338	NS
STAD	Stomach adenocarcinoma	406	-0.038	0.447	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.224	1.59e-07	Higher

Summary
Symbol	MTA2
Name	metastasis associated 1 family member 2
Aliases	MTA1-L1; MTA1L1; metastasis associated gene family, member 2; PID; MTA1-L1 protein; metastasis -associated g ......
Location	11q12.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	MTA2
Name	metastasis associated 1 family member 2
Aliases	MTA1-L1; MTA1L1; metastasis associated gene family, member 2; PID; MTA1-L1 protein; metastasis -associated g ......
Location	11q12.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for MTA2.

Summary
Symbol	MTA2
Name	metastasis associated 1 family member 2
Aliases	MTA1-L1; MTA1L1; metastasis associated gene family, member 2; PID; MTA1-L1 protein; metastasis -associated g ......
Location	11q12.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
12705869	Glioma	upstream	mR-548b	Negative regulation	miR-548b was underexpressed in human glioma tissues and cell lines. Re-expression of miR-548b significantly inhibited the proliferation and colony formation of U87 and U373 glioma cells. Enforced expression of miR-548b significantly impaired the invasiveness of glioma cells. Notably, metastasis tumor-associated protein-2 (MTA2) was a direct target of miR-548b. Overexpression of miR-548b negatively regulated endogenous MTA2 expression in U87 cells.
27051300	Nasopharyngeal Carcinoma	downstream	Akt; matrix metalloproteinase 7; cyclin D1	Positive regulation	MTA2 overexpression activated Akt and upregulated the expression of matrix metalloproteinase 7 and cyclin D1.
26722504	Hepatocellular Carcinoma	partner	Ki-67	Positive correlation	We found MTA2 and Ki-67 were both increased in HCC tissues than those in adjacent tissues and nuclear MTA2 was associated with Ki-67 (P = 0.019).
25969565	Lung Carcinoma	downstream	Ep-CAM; E-cadherin	Negative regulation	Metastasis-associated protein 2 promoted cell migration and invasion in vitro and in vivo through binding on the promoter of Ep-CAM and E-cadherin. Luciferase reporter assays showed repressed or enhanced E-cadherin or Ep-CAM promoter-driven luciferase reporter under metastasis-associated protein 2 overexpression or depletion.
24468085	Colon Carcinoma	partner	p300	Acetylation	Here, we report that MTA2 is acetylated at K152 and histone acetyltransferase p300 binds to and acetylates MTA2.
23158992	Gastric Carcinoma	partner	Sp1	Positive correlation	Furthermore, MTA2 expression was concomitant with Sp1 expression (r = 0.320, P < 0.05). Elevated MTA2 expression was observed in Sp1 positive cancer tissues (χ(2) = 9.565, P < 0.01). RT-PCR results also demonstrated that MTA2 mRNA was also highly expressed in the tissue samples with Sp1 expression.
28502558	Gastric Carcinoma	partner	HADC1	Positive correlation	The present findings indicated a tight correlation between the MTA2 and HDAC1 expression level and lymph node metastasis and TNM staging in gastric cancers.