CR2Cancer

Summary
Symbol	NCOA2
Name	nuclear receptor coactivator 2
Aliases	TIF2; NCoA-2; KAT13C; bHLHe75; class E basic helix-loop-helix protein 75; glucocorticoid receptor-interactin ......
Location	8q13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

[ TOP ]

Domain

PF07469 Domain of unknown function (DUF1518)
PF16279 Domain of unknown function (DUF4927)
PF08815 Nuclear receptor coactivator
PF00989 PAS fold
PF08832 Steroid receptor coactivator

Function

Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues. Critical regulator of glucose metabolism regulation, acts as RORA coactivator to specifically modulate G6PC expression. Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3. Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-ARNTL/BMAL1 heterodimer (By similarity).

Classification

Class	Modification	Substrate	Product	PubMed
Chromatin remodelling cofactor	#	#	#	9590696

> Gene Ontology [ TOP ]
Biological Process	GO:0005996 monosaccharide metabolic process GO:0006006 glucose metabolic process GO:0006109 regulation of carbohydrate metabolic process GO:0006473 protein acetylation GO:0006475 internal protein amino acid acetylation GO:0006820 anion transport GO:0006869 lipid transport GO:0007622 rhythmic behavior GO:0007623 circadian rhythm GO:0007626 locomotory behavior GO:0010469 regulation of receptor activity GO:0010675 regulation of cellular carbohydrate metabolic process GO:0010876 lipid localization GO:0010906 regulation of glucose metabolic process GO:0015711 organic anion transport GO:0015718 monocarboxylic acid transport GO:0015721 bile acid and bile salt transport GO:0015849 organic acid transport GO:0015850 organic hydroxy compound transport GO:0016570 histone modification GO:0016573 histone acetylation GO:0018205 peptidyl-lysine modification GO:0018393 internal peptidyl-lysine acetylation GO:0018394 peptidyl-lysine acetylation GO:0019318 hexose metabolic process GO:0030522 intracellular receptor signaling pathway GO:0032922 circadian regulation of gene expression GO:0043543 protein acylation GO:0044262 cellular carbohydrate metabolic process GO:0044723 single-organism carbohydrate metabolic process GO:0045475 locomotor rhythm GO:0046942 carboxylic acid transport GO:0048511 rhythmic process GO:0048512 circadian behavior GO:1904016 response to Thyroglobulin triiodothyronine GO:1904017 cellular response to Thyroglobulin triiodothyronine GO:2000273 positive regulation of receptor activity
Molecular Function	GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000987 core promoter proximal region sequence-specific DNA binding GO:0001159 core promoter proximal region DNA binding GO:0001161 intronic transcription regulatory region sequence-specific DNA binding GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding GO:0003682 chromatin binding GO:0003713 transcription coactivator activity GO:0004402 histone acetyltransferase activity GO:0008080 N-acetyltransferase activity GO:0008134 transcription factor binding GO:0010861 thyroid hormone receptor activator activity GO:0016407 acetyltransferase activity GO:0016410 N-acyltransferase activity GO:0016746 transferase activity, transferring acyl groups GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GO:0016922 ligand-dependent nuclear receptor binding GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity GO:0030375 thyroid hormone receptor coactivator activity GO:0030545 receptor regulator activity GO:0030546 receptor activator activity GO:0034212 peptide N-acetyltransferase activity GO:0035257 nuclear hormone receptor binding GO:0044213 intronic transcription regulatory region DNA binding GO:0051427 hormone receptor binding GO:0061733 peptide-lysine-N-acetyltransferase activity
Cellular Component	-

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04919 Thyroid hormone signaling pathway
Reactome	R-HSA-5625886: Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-2426168: Activation of gene expression by SREBF (SREBP) R-HSA-1368108: BMAL1 R-HSA-194068: Bile acid and bile salt metabolism R-HSA-211859: Biological oxidations R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-400253: Circadian Clock R-HSA-211897: Cytochrome P450 - arranged by substrate type R-HSA-1266738: Developmental Biology R-HSA-211976: Endogenous sterols R-HSA-535734: Fatty acid, triacylglycerol, and ketone body metabolism R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-3214847: HATs acetylate histones R-HSA-1430728: Metabolism R-HSA-556833: Metabolism of lipids and lipoproteins R-HSA-1592230: Mitochondrial biogenesis R-HSA-1852241: Organelle biogenesis and maintenance R-HSA-1989781: PPARA activates gene expression R-HSA-211945: Phase 1 - Functionalization of compounds R-HSA-195258: RHO GTPase Effectors R-HSA-5625740: RHO GTPases activate PKNs R-HSA-1368082: RORA activates gene expression R-HSA-159418: Recycling of bile acids and salts R-HSA-1655829: Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-400206: Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) R-HSA-162582: Signal Transduction R-HSA-194315: Signaling by Rho GTPases R-HSA-192105: Synthesis of bile acids and bile salts R-HSA-193807: Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193368: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-2151201: Transcriptional activation of mitochondrial biogenesis R-HSA-381340: Transcriptional regulation of white adipocyte differentiation R-HSA-2032785: YAP1- and WWTR1 (TAZ)-stimulated gene expression

> KEGG and Reactome Pathway

[ TOP ]

KEGG

hsa04919 Thyroid hormone signaling pathway

Reactome

R-HSA-5625886: Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
R-HSA-2426168: Activation of gene expression by SREBF (SREBP)
R-HSA-1368108: BMAL1
R-HSA-194068: Bile acid and bile salt metabolism
R-HSA-211859: Biological oxidations
R-HSA-3247509: Chromatin modifying enzymes
R-HSA-4839726: Chromatin organization
R-HSA-400253: Circadian Clock
R-HSA-211897: Cytochrome P450 - arranged by substrate type
R-HSA-1266738: Developmental Biology
R-HSA-211976: Endogenous sterols
R-HSA-535734: Fatty acid, triacylglycerol, and ketone body metabolism
R-HSA-74160: Gene Expression
R-HSA-212436: Generic Transcription Pathway
R-HSA-3214847: HATs acetylate histones
R-HSA-1430728: Metabolism
R-HSA-556833: Metabolism of lipids and lipoproteins
R-HSA-1592230: Mitochondrial biogenesis
R-HSA-1852241: Organelle biogenesis and maintenance
R-HSA-1989781: PPARA activates gene expression
R-HSA-211945: Phase 1 - Functionalization of compounds
R-HSA-195258: RHO GTPase Effectors
R-HSA-5625740: RHO GTPases activate PKNs
R-HSA-1368082: RORA activates gene expression
R-HSA-159418: Recycling of bile acids and salts
R-HSA-1655829: Regulation of cholesterol biosynthesis by SREBP (SREBF)
R-HSA-400206: Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
R-HSA-162582: Signal Transduction
R-HSA-194315: Signaling by Rho GTPases
R-HSA-192105: Synthesis of bile acids and bile salts
R-HSA-193807: Synthesis of bile acids and bile salts via 27-hydroxycholesterol
R-HSA-193368: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
R-HSA-2151201: Transcriptional activation of mitochondrial biogenesis
R-HSA-381340: Transcriptional regulation of white adipocyte differentiation
R-HSA-2032785: YAP1- and WWTR1 (TAZ)-stimulated gene expression

Summary
Symbol	NCOA2
Name	nuclear receptor coactivator 2
Aliases	TIF2; NCoA-2; KAT13C; bHLHe75; class E basic helix-loop-helix protein 75; glucocorticoid receptor-interactin ......
Location	8q13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM3663863	c.1746A>G	p.S582S	Substitution - coding silent	Liver
COSM4485337	c.2920C>T	p.R974W	Substitution - Missense	Skin
COSM454814	c.1375C>T	p.Q459*	Substitution - Nonsense	Breast
COSM5719080	c.4384-2A>G	p.?	Unknown	Skin
COSM3663864	c.323G>A	p.G108D	Substitution - Missense	Liver
COSM4966764	c.3810G>T	p.L1270F	Substitution - Missense	Prostate
COSM5815949	c.1794A>G	p.G598G	Substitution - coding silent	Liver
COSM3901354	c.268G>A	p.A90T	Substitution - Missense	Stomach
COSM5469066	c.2973G>A	p.R991R	Substitution - coding silent	Large_intestine
COSM1101422	c.545A>C	p.N182T	Substitution - Missense	Endometrium
COSM1216851	c.1909G>T	p.G637W	Substitution - Missense	Large_intestine
COSM750806	c.1633G>A	p.G545R	Substitution - Missense	Lung
COSM4588185	c.2689A>G	p.T897A	Substitution - Missense	Bone
COSM3781469	c.4031A>G	p.N1344S	Substitution - Missense	Pancreas
COSM3901344	c.1212C>A	p.A404A	Substitution - coding silent	Stomach
COSM1101403	c.4054G>A	p.D1352N	Substitution - Missense	Endometrium
COSM750805	c.1472G>A	p.R491H	Substitution - Missense	Lung
COSM4973251	c.864G>A	p.M288I	Substitution - Missense	Oesophagus
COSM1314178	c.4145G>A	p.S1382N	Substitution - Missense	Urinary_tract
COSM355307	c.1784G>T	p.G595V	Substitution - Missense	Lung
COSM257501	c.2791A>C	p.N931H	Substitution - Missense	Large_intestine
COSM2874663	c.450C>T	p.N150N	Substitution - coding silent	Large_intestine
COSM750807	c.2432A>T	p.D811V	Substitution - Missense	Lung
COSM5719080	c.4384-2A>G	p.?	Unknown	Skin
COSM3901355	c.223G>T	p.E75*	Substitution - Nonsense	Stomach
COSM5893304	c.364-6C>T	p.?	Unknown	Skin
COSM4421769	c.2606-1G>C	p.?	Unknown	Pleura
COSM1101402	c.4107G>A	p.Q1369Q	Substitution - coding silent	Endometrium
COSM75575	c.3617T>G	p.L1206R	Substitution - Missense	Ovary
COSM3901349	c.783A>C	p.R261S	Substitution - Missense	Stomach
COSM3779334	c.3011C>G	p.S1004C	Substitution - Missense	Urinary_tract
COSM1101412	c.3263G>A	p.R1088Q	Substitution - Missense	Endometrium
COSM3901332	c.4355T>G	p.M1452R	Substitution - Missense	Stomach
COSM1101409	c.3699G>T	p.Q1233H	Substitution - Missense	Endometrium
COSM3925537	c.4049C>T	p.P1350L	Substitution - Missense	Skin
COSM3901336	c.3743G>A	p.R1248Q	Substitution - Missense	Stomach
COSM1242561	c.2867C>T	p.P956L	Substitution - Missense	Oesophagus
COSM2874670	c.225A>G	p.E75E	Substitution - coding silent	Large_intestine
COSM3925539	c.2466C>T	p.F822F	Substitution - coding silent	Skin
COSM5639928	c.4329C>T	p.F1443F	Substitution - coding silent	Oesophagus
COSM750803	c.1151C>T	p.P384L	Substitution - Missense	Skin
COSM2874661	c.600T>C	p.C200C	Substitution - coding silent	Large_intestine
COSM3951832	c.2668G>A	p.D890N	Substitution - Missense	Lung
COSM365409	c.3523G>T	p.G1175C	Substitution - Missense	Lung
COSM1489407	c.703C>A	p.P235T	Substitution - Missense	Breast
COSM94808	c.486C>G	p.I162M	Substitution - Missense	Breast
COSM4919272	c.1705A>G	p.M569V	Substitution - Missense	Liver
COSM3834974	c.2933G>A	p.G978E	Substitution - Missense	Breast
COSM1458083	c.565G>A	p.E189K	Substitution - Missense	Large_intestine
COSM3413106	c.1323T>C	p.F441F	Substitution - coding silent	Central_nervous_system
COSM2874582	c.3277C>A	p.L1093M	Substitution - Missense	Large_intestine
COSM4765836	c.3941_3942insA	p.F1315fs*72	Insertion - Frameshift	Stomach
COSM4938538	c.974A>G	p.E325G	Substitution - Missense	Liver
COSM4151564	c.4150T>A	p.Y1384N	Substitution - Missense	Ovary
COSM3663864	c.323G>A	p.G108D	Substitution - Missense	Liver
COSM4445165	c.2837G>A	p.R946Q	Substitution - Missense	Large_intestine
COSM22019	c.3094C>G	p.Q1032E	Substitution - Missense	Lung
COSM3901346	c.1044T>C	p.A348A	Substitution - coding silent	Stomach
COSM3901333	c.4352A>G	p.D1451G	Substitution - Missense	Stomach
COSM5885282	c.?	p.S662L	Substitution - Missense	Breast
COSM4705945	c.833-1G>T	p.?	Unknown	Large_intestine
COSM5467489	c.1837A>C	p.N613H	Substitution - Missense	Large_intestine
COSM2874663	c.450C>T	p.N150N	Substitution - coding silent	Large_intestine
COSM22020	c.603G>C	p.R201R	Substitution - coding silent	Lung
COSM3650684	c.2323C>T	p.P775S	Substitution - Missense	Skin
COSM3650682	c.3858G>A	p.M1286I	Substitution - Missense	Skin
COSM2874597	c.2808C>T	p.S936S	Substitution - coding silent	Large_intestine
COSM3901348	c.1025C>T	p.S342F	Substitution - Missense	Stomach
COSM1458071	c.1607C>T	p.A536V	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5817867	c.4301A>G	p.D1434G	Substitution - Missense	Liver
COSM378531	c.656A>T	p.E219V	Substitution - Missense	Lung
COSM4998655	c.2045C>T	p.S682L	Substitution - Missense	Pancreas
COSM4972489	c.2672T>C	p.I891T	Substitution - Missense	Oesophagus
COSM1624177	c.1624G>A	p.E542K	Substitution - Missense	Liver
COSM5409829	c.60G>A	p.K20K	Substitution - coding silent	Skin
COSM1731502	c.2160_2174del15	p.S720_G725>R	Complex - deletion inframe	Liver
COSM3901334	c.4285C>T	p.P1429S	Substitution - Missense	Stomach
COSM750800	c.887G>A	p.W296*	Substitution - Nonsense	Lung
COSM3367400	c.2278C>A	p.P760T	Substitution - Missense	Kidney
COSM3650685	c.1694C>T	p.S565F	Substitution - Missense	Skin
COSM1458070	c.2147G>A	p.S716N	Substitution - Missense	Large_intestine
COSM486636	c.3822A>C	p.P1274P	Substitution - coding silent	Kidney
COSM3834975	c.2529C>A	p.L843L	Substitution - coding silent	Breast
COSM4705943	c.1915A>C	p.T639P	Substitution - Missense	Large_intestine
COSM4151565	c.3904C>T	p.P1302S	Substitution - Missense	Ovary
COSM2874670	c.225A>G	p.E75E	Substitution - coding silent	Large_intestine
COSM1196836	c.1699G>T	p.V567F	Substitution - Missense	Lung
COSM3901338	c.3361G>A	p.D1121N	Substitution - Missense	Stomach
COSM262329	c.1756T>C	p.F586L	Substitution - Missense	Large_intestine
COSM3650689	c.124G>A	p.E42K	Substitution - Missense	Skin
COSM94805	c.2545G>A	p.E849K	Substitution - Missense	Breast
COSM223274	c.4064G>A	p.G1355E	Substitution - Missense	Skin
COSM5358670	c.3608G>A	p.R1203H	Substitution - Missense	Large_intestine
COSM4608020	c.4126G>T	p.G1376W	Substitution - Missense	Adrenal_gland
COSM2874565	c.3985C>T	p.R1329*	Substitution - Nonsense	Breast
COSM1458067	c.3325A>G	p.S1109G	Substitution - Missense	Large_intestine
COSM1314179	c.1951C>T	p.Q651*	Substitution - Nonsense	Urinary_tract
COSM5768327	c.3915C>T	p.Y1305Y	Substitution - coding silent	Breast
COSM5351522	c.3415T>A	p.S1139T	Substitution - Missense	Lung
COSM2874668	c.249C>T	p.I83I	Substitution - coding silent	Large_intestine
COSM1216852	c.1012C>T	p.R338C	Substitution - Missense	Large_intestine
COSM2874563	c.4104C>T	p.S1368S	Substitution - coding silent	Skin
COSM3901343	c.1861G>A	p.V621M	Substitution - Missense	Stomach
COSM3925536	c.4275C>T	p.S1425S	Substitution - coding silent	Skin
COSM4436937	c.2524G>A	p.D842N	Substitution - Missense	Oesophagus
COSM2874629	c.1881C>T	p.D627D	Substitution - coding silent	Large_intestine
COSM4632487	c.1965G>A	p.S655S	Substitution - coding silent	Large_intestine
COSM5409825	c.2209C>T	p.P737S	Substitution - Missense	Skin
COSM3650687	c.1525C>T	p.P509S	Substitution - Missense	Skin
COSM3901339	c.2543C>T	p.A848V	Substitution - Missense	Stomach
COSM750805	c.1472G>A	p.R491H	Substitution - Missense	Stomach
COSM398388	c.4352A>T	p.D1451V	Substitution - Missense	Lung
COSM5581820	c.1695C>T	p.S565S	Substitution - coding silent	Skin
COSM5943403	c.3917-4delT	p.?	Unknown	Skin
COSM3901351	c.506C>T	p.T169M	Substitution - Missense	Stomach
COSM5409828	c.1966C>T	p.P656S	Substitution - Missense	Skin
COSM3901335	c.4070C>T	p.A1357V	Substitution - Missense	Stomach
COSM3901350	c.664C>T	p.Q222*	Substitution - Nonsense	Stomach
COSM3663865	c.266C>T	p.A89V	Substitution - Missense	Liver
COSM3663863	c.1746A>G	p.S582S	Substitution - coding silent	Liver
COSM4705946	c.817C>T	p.R273C	Substitution - Missense	Large_intestine
COSM454813	c.1863G>A	p.V621V	Substitution - coding silent	Breast
COSM387901	c.3502C>T	p.L1168F	Substitution - Missense	Lung
COSM3901340	c.2304A>G	p.R768R	Substitution - coding silent	Stomach
COSM3834976	c.1509A>C	p.P503P	Substitution - coding silent	Breast
COSM5574795	c.505A>G	p.T169A	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM2874573	c.3632G>A	p.S1211N	Substitution - Missense	Large_intestine
COSM3834973	c.3729G>A	p.L1243L	Substitution - coding silent	Breast
COSM372322	c.3491G>T	p.S1164I	Substitution - Missense	Lung
COSM1569564	c.2945G>A	p.R982Q	Substitution - Missense	Large_intestine
COSM3901337	c.3496G>A	p.A1166T	Substitution - Missense	Stomach
COSM2874590	c.3003G>A	p.T1001T	Substitution - coding silent	Large_intestine
COSM4777698	c.541delG	p.V181fs*1	Deletion - Frameshift	Prostate
COSM4469380	c.1598C>T	p.S533F	Substitution - Missense	Skin
COSM1663014	c.2636G>A	p.G879D	Substitution - Missense	Kidney
COSM1101421	c.690C>T	p.F230F	Substitution - coding silent	Endometrium
COSM3834977	c.273T>G	p.A91A	Substitution - coding silent	Breast
COSM218961	c.1793G>T	p.G598V	Substitution - Missense	Pancreas
COSM249393	c.4282G>T	p.G1428C	Substitution - Missense	Kidney
COSM1216855	c.1346A>C	p.H449P	Substitution - Missense	Large_intestine
COSM1458071	c.1607C>T	p.A536V	Substitution - Missense	Large_intestine
COSM3669919	c.3997A>G	p.T1333A	Substitution - Missense	Liver
COSM454812	c.2484C>T	p.G828G	Substitution - coding silent	Breast
COSM5893304	c.364-6C>T	p.?	Unknown	Skin
COSM3901345	c.1113T>C	p.H371H	Substitution - coding silent	Stomach
COSM5409827	c.2008G>A	p.G670S	Substitution - Missense	Skin
COSM3650688	c.1276C>T	p.P426S	Substitution - Missense	Skin
COSM4971049	c.3670G>A	p.V1224I	Substitution - Missense	Central_nervous_system
COSM1458063	c.4381C>T	p.R1461W	Substitution - Missense	Pancreas
COSM1101410	c.3539G>A	p.G1180D	Substitution - Missense	Endometrium
COSM3951831	c.2952A>G	p.P984P	Substitution - coding silent	Lung
COSM230153	c.1523C>T	p.S508F	Substitution - Missense	Skin
COSM3669919	c.3997A>G	p.T1333A	Substitution - Missense	Liver
COSM5440983	c.3824G>A	p.S1275N	Substitution - Missense	Oesophagus
COSM1242561	c.2867C>T	p.P956L	Substitution - Missense	Kidney
COSM1216851	c.1909G>T	p.G637W	Substitution - Missense	Stomach
COSM218961	c.1793G>T	p.G598V	Substitution - Missense	Pancreas
COSM486638	c.1834A>G	p.T612A	Substitution - Missense	Kidney
COSM3901352	c.471A>C	p.K157N	Substitution - Missense	Stomach
COSM1258837	c.3603+1G>A	p.?	Unknown	Oesophagus
COSM1101411	c.3310G>A	p.E1104K	Substitution - Missense	Endometrium
COSM3901342	c.2064A>C	p.K688N	Substitution - Missense	Stomach
COSM1101408	c.3742C>T	p.R1248*	Substitution - Nonsense	Endometrium
COSM5621357	c.1844C>T	p.P615L	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1101419	c.1470T>C	p.H490H	Substitution - coding silent	Endometrium
COSM335744	c.4182G>T	p.M1394I	Substitution - Missense	Lung
COSM3925538	c.3505C>T	p.R1169C	Substitution - Missense	Skin
COSM4940437	c.3841G>A	p.G1281S	Substitution - Missense	Liver
COSM4705944	c.1195A>G	p.S399G	Substitution - Missense	Large_intestine
COSM1458064	c.3956C>T	p.T1319M	Substitution - Missense	Large_intestine
COSM2874668	c.249C>T	p.I83I	Substitution - coding silent	Large_intestine
COSM3650681	c.4053C>T	p.S1351S	Substitution - coding silent	Skin
COSM5679873	c.770C>T	p.P257L	Substitution - Missense	Soft_tissue
COSM4006958	c.1912C>T	p.Q638*	Substitution - Nonsense	Urinary_tract
COSM2874583	c.3200A>G	p.H1067R	Substitution - Missense	Large_intestine
COSM3942736	c.2249A>T	p.D750V	Substitution - Missense	Oesophagus
COSM5434221	c.1655T>C	p.L552S	Substitution - Missense	Oesophagus
COSM22058	c.1316G>A	p.G439D	Substitution - Missense	Skin
COSM4888482	c.1219G>C	p.A407P	Substitution - Missense	Upper_aerodigestive_tract
COSM673971	c.1308G>A	p.M436I	Substitution - Missense	Endometrium
COSM3663862	c.3704T>A	p.L1235Q	Substitution - Missense	Liver
COSM1458077	c.1081A>G	p.T361A	Substitution - Missense	Large_intestine
COSM1101405	c.3986G>A	p.R1329Q	Substitution - Missense	Endometrium
COSM4595458	c.1069C>T	p.R357C	Substitution - Missense	Upper_aerodigestive_tract
COSM5808525	c.552A>G	p.G184G	Substitution - coding silent	Liver
COSM5409825	c.2209C>T	p.P737S	Substitution - Missense	Skin
COSM2874663	c.450C>T	p.N150N	Substitution - coding silent	Large_intestine
COSM22019	c.3094C>G	p.Q1032E	Substitution - Missense	Lung
COSM1216856	c.286G>T	p.E96*	Substitution - Nonsense	Large_intestine
COSM5046503	c.2570G>C	p.G857A	Substitution - Missense	Oesophagus
COSM94807	c.1553G>T	p.G518V	Substitution - Missense	Lung
COSM4613766	c.3059delG	p.G1020fs*24	Deletion - Frameshift	Large_intestine
COSM5500452	c.166A>G	p.N56D	Substitution - Missense	Biliary_tract
COSM1552800	c.4087G>A	p.G1363R	Substitution - Missense	Large_intestine
COSM2874583	c.3200A>G	p.H1067R	Substitution - Missense	Large_intestine
COSM390324	c.1870G>A	p.E624K	Substitution - Missense	Lung
COSM2157817	c.583_584insC	p.S195fs*15	Insertion - Frameshift	Central_nervous_system
COSM3663862	c.3704T>A	p.L1235Q	Substitution - Missense	Liver
COSM750808	c.3037G>C	p.E1013Q	Substitution - Missense	Lung
COSM1101408	c.3742C>T	p.R1248*	Substitution - Nonsense	Large_intestine
COSM3901347	c.1031G>A	p.G344D	Substitution - Missense	Stomach
COSM4705946	c.817C>T	p.R273C	Substitution - Missense	Stomach
COSM1101413	c.2599C>A	p.Q867K	Substitution - Missense	Endometrium
COSM4151565	c.3904C>T	p.P1302S	Substitution - Missense	Skin
COSM1101418	c.2046G>A	p.S682S	Substitution - coding silent	Endometrium
COSM1196836	c.1699G>T	p.V567F	Substitution - Missense	Lung
COSM383564	c.1741G>T	p.D581Y	Substitution - Missense	Lung
COSM1719632	c.1506C>T	p.I502I	Substitution - coding silent	Skin
COSM1286523	c.378C>T	p.F126F	Substitution - coding silent	Autonomic_ganglia
COSM3650683	c.2728C>T	p.P910S	Substitution - Missense	Skin
COSM1635854	c.3390G>A	p.A1130A	Substitution - coding silent	Liver
COSM3982580	c.3846G>C	p.M1282I	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM377742	c.4042C>T	p.Q1348*	Substitution - Nonsense	Cervix
COSM3650690	c.67C>T	p.P23S	Substitution - Missense	Skin
COSM5631364	c.1707_1708insT	p.N570fs*1	Insertion - Frameshift	Oesophagus
COSM1458077	c.1081A>G	p.T361A	Substitution - Missense	Large_intestine
COSM3413104	c.2655G>C	p.Q885H	Substitution - Missense	Central_nervous_system
COSM4429332	c.319C>G	p.Q107E	Substitution - Missense	Oesophagus
COSM389656	c.142G>T	p.E48*	Substitution - Nonsense	Lung
COSM3650686	c.1547C>T	p.P516L	Substitution - Missense	Skin
COSM1489408	c.254A>T	p.E85V	Substitution - Missense	Breast
COSM3996117	c.201T>G	p.P67P	Substitution - coding silent	Kidney
COSM1719632	c.1506C>T	p.I502I	Substitution - coding silent	Skin
COSM5949842	c.684G>A	p.Q228Q	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM750801	c.1070G>T	p.R357L	Substitution - Missense	Lung
COSM3929620	c.3170G>A	p.G1057D	Substitution - Missense	Central_nervous_system
COSM750804	c.1337G>A	p.G446E	Substitution - Missense	Lung
COSM750805	c.1472G>A	p.R491H	Substitution - Missense	Stomach
COSM1101408	c.3742C>T	p.R1248*	Substitution - Nonsense	Prostate
COSM2874597	c.2808C>T	p.S936S	Substitution - coding silent	Large_intestine
COSM4488928	c.3400C>T	p.P1134S	Substitution - Missense	Skin
COSM1458079	c.790C>A	p.L264I	Substitution - Missense	Large_intestine
COSM4777698	c.541delG	p.V181fs*1	Deletion - Frameshift	Prostate
COSM5358670	c.3608G>A	p.R1203H	Substitution - Missense	Large_intestine
COSM3413105	c.2620C>T	p.R874*	Substitution - Nonsense	Central_nervous_system
COSM4924801	c.4287C>T	p.P1429P	Substitution - coding silent	Liver
COSM1216857	c.2860T>C	p.W954R	Substitution - Missense	Large_intestine
COSM4976706	c.607C>T	p.L203L	Substitution - coding silent	Oesophagus
COSM5791018	c.2479C>G	p.P827A	Substitution - Missense	Breast
COSM3982580	c.3846G>C	p.M1282I	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1101423	c.152A>G	p.E51G	Substitution - Missense	Endometrium
COSM5808613	c.697T>A	p.S233T	Substitution - Missense	Liver
COSM1216854	c.3137C>T	p.A1046V	Substitution - Missense	Large_intestine
COSM2874593	c.2944C>T	p.R982W	Substitution - Missense	Large_intestine
COSM3413105	c.2620C>T	p.R874*	Substitution - Nonsense	Biliary_tract
COSM4138730	c.549G>T	p.G183G	Substitution - coding silent	Kidney
COSM2874629	c.1881C>T	p.D627D	Substitution - coding silent	Oesophagus
COSM4891152	c.3747G>C	p.Q1249H	Substitution - Missense	Upper_aerodigestive_tract
COSM2874583	c.3200A>G	p.H1067R	Substitution - Missense	Large_intestine
COSM162836	c.1172T>G	p.M391R	Substitution - Missense	Breast
COSM3901353	c.442A>C	p.R148R	Substitution - coding silent	Stomach
COSM2874669	c.241C>T	p.R81C	Substitution - Missense	Urinary_tract
COSM4705946	c.817C>T	p.R273C	Substitution - Missense	Oesophagus
COSM3685411	c.585C>A	p.S195R	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5574795	c.505A>G	p.T169A	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5063313	c.1719A>G	p.P573P	Substitution - coding silent	Stomach
COSM5480289	c.3389C>T	p.A1130V	Substitution - Missense	Large_intestine
COSM1242561	c.2867C>T	p.P956L	Substitution - Missense	Stomach
COSM1101415	c.2542G>A	p.A848T	Substitution - Missense	Endometrium
COSM1216853	c.842C>T	p.T281M	Substitution - Missense	Large_intestine
COSM5432838	c.1463C>T	p.P488L	Substitution - Missense	Oesophagus
COSM5446500	c.3874_3875delCC	p.Q1293fs*19	Deletion - Frameshift	Thyroid
COSM5498562	c.3353C>G	p.S1118*	Substitution - Nonsense	Biliary_tract
COSM245964	c.3139T>C	p.S1047P	Substitution - Missense	Prostate
COSM4942965	c.321G>T	p.Q107H	Substitution - Missense	Liver
COSM321964	c.4032C>A	p.N1344K	Substitution - Missense	Lung
COSM750798	c.565G>T	p.E189*	Substitution - Nonsense	Lung
COSM750797	c.415G>T	p.V139L	Substitution - Missense	Lung
COSM1330918	c.1330T>A	p.S444T	Substitution - Missense	Ovary
COSM1739488	c.79G>A	p.G27R	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM2874569	c.3718A>G	p.R1240G	Substitution - Missense	Large_intestine
COSM4705942	c.2475G>C	p.T825T	Substitution - coding silent	Large_intestine
COSM5560695	c.3644A>G	p.N1215S	Substitution - Missense	Prostate
COSM5772530	c.2227G>A	p.A743T	Substitution - Missense	Breast
COSM3901341	c.2236C>T	p.R746C	Substitution - Missense	Stomach
COSM1458065	c.3766C>T	p.Q1256*	Substitution - Nonsense	Large_intestine
COSM5719080	c.4384-2A>G	p.?	Unknown	Skin
COSM5368779	c.4255G>A	p.V1419M	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM85128	c.4017A>G	p.Q1339Q	Substitution - coding silent	Pancreas
COSM4559561	c.80G>A	p.G27E	Substitution - Missense	Skin
COSM3663865	c.266C>T	p.A89V	Substitution - Missense	Liver
COSM1101414	c.2593delA	p.I865fs*49	Deletion - Frameshift	Endometrium
COSM5904320	c.3916+1G>A	p.?	Unknown	Skin
COSM1101420	c.1008C>A	p.I336I	Substitution - coding silent	Endometrium
COSM2874641	c.1338A>C	p.G446G	Substitution - coding silent	Upper_aerodigestive_tract
COSM5801956	c.4383+8_4383+11delAGAA	p.?	Unknown	Breast
COSM1458069	c.2847G>A	p.M949I	Substitution - Missense	Large_intestine
COSM1101406	c.3891G>A	p.Q1297Q	Substitution - coding silent	Endometrium
COSM750799	c.771C>A	p.P257P	Substitution - coding silent	Lung
COSM223275	c.3416C>T	p.S1139F	Substitution - Missense	Skin
COSM1719632	c.1506C>T	p.I502I	Substitution - coding silent	Skin
COSM1101407	c.3782G>A	p.R1261Q	Substitution - Missense	Endometrium
COSM3925540	c.1843C>T	p.P615S	Substitution - Missense	Skin
COSM96064	c.933T>C	p.H311H	Substitution - coding silent	Lung
COSM301383	c.1110A>G	p.L370L	Substitution - coding silent	Large_intestine
COSM1458084	c.37A>T	p.R13W	Substitution - Missense	Large_intestine
COSM5409826	c.2208C>T	p.S736S	Substitution - coding silent	Skin
COSM304591	c.4382G>A	p.R1461Q	Substitution - Missense	Large_intestine
COSM4836883	c.33C>T	p.P11P	Substitution - coding silent	Cervix
COSM4163052	c.2112C>A	p.A704A	Substitution - coding silent	Thyroid
COSM4421186	c.3946A>C	p.T1316P	Substitution - Missense	Pleura
COSM4777698	c.541delG	p.V181fs*1	Deletion - Frameshift	Prostate
COSM5346389	c.4094G>A	p.S1365N	Substitution - Missense	Urinary_tract
COSM4968462	c.3159-8C>G	p.?	Unknown	Adrenal_gland
COSM5719080	c.4384-2A>G	p.?	Unknown	Skin
COSM5719080	c.4384-2A>G	p.?	Unknown	Skin
COSM2874597	c.2808C>T	p.S936S	Substitution - coding silent	Large_intestine
COSM2874656	c.847C>T	p.L283L	Substitution - coding silent	Large_intestine
COSM4389717	c.4185G>A	p.A1395A	Substitution - coding silent	Pancreas
COSM5575648	c.2267A>T	p.D756V	Substitution - Missense	Stomach
COSM4421767	c.3340C>G	p.P1114A	Substitution - Missense	Pleura
COSM4969648	c.3347A>G	p.Q1116R	Substitution - Missense	Central_nervous_system
COSM169326	c.926C>T	p.A309V	Substitution - Missense	Endometrium
COSM1624177	c.1624G>A	p.E542K	Substitution - Missense	Liver
COSM5987525	c.661C>T	p.H221Y	Substitution - Missense	Salivary_gland
COSM3925538	c.3505C>T	p.R1169C	Substitution - Missense	Bone
COSM1101407	c.3782G>A	p.R1261Q	Substitution - Missense	Skin
COSM5048070	c.280A>G	p.I94V	Substitution - Missense	Oesophagus
COSM5943403	c.3917-4delT	p.?	Unknown	Skin
COSM486637	c.3039A>G	p.E1013E	Substitution - coding silent	Kidney
COSM750803	c.1151C>T	p.P384L	Substitution - Missense	Lung
COSM4006957	c.2063A>G	p.K688R	Substitution - Missense	Urinary_tract
COSM1101417	c.2356A>G	p.T786A	Substitution - Missense	Endometrium
COSM4526552	c.1401G>T	p.M467I	Substitution - Missense	Skin
COSM94806	c.2174G>T	p.G725V	Substitution - Missense	Lung
COSM4974566	c.3868C>T	p.R1290W	Substitution - Missense	Oesophagus
COSM4421768	c.3628_3629insA	p.I1210fs*22	Insertion - Frameshift	Pleura
COSM4163051	c.2524G>T	p.D842Y	Substitution - Missense	Thyroid
COSM3745657	c.2144T>C	p.L715P	Substitution - Missense	Liver
COSM377742	c.4042C>T	p.Q1348*	Substitution - Nonsense	Lung
COSM94804	c.3348G>T	p.Q1116H	Substitution - Missense	Lung
COSM4600938	c.1184T>C	p.L395P	Substitution - Missense	Upper_aerodigestive_tract
COSM750809	c.3244C>T	p.Q1082*	Substitution - Nonsense	Lung
COSM2874661	c.600T>C	p.C200C	Substitution - coding silent	Large_intestine
COSM377742	c.4042C>T	p.Q1348*	Substitution - Nonsense	Endometrium
COSM22018	c.1408C>T	p.P470S	Substitution - Missense	Skin
COSM750802	c.1093C>T	p.Q365*	Substitution - Nonsense	Lung
COSM2874629	c.1881C>T	p.D627D	Substitution - coding silent	Large_intestine
COSM3942737	c.1496G>A	p.S499N	Substitution - Missense	Oesophagus
COSM5476827	c.1260T>C	p.S420S	Substitution - coding silent	Large_intestine
COSM169326	c.926C>T	p.A309V	Substitution - Missense	Stomach
COSM2874605	c.2658T>C	p.N886N	Substitution - coding silent	Stomach
COSM245965	c.114T>A	p.N38K	Substitution - Missense	Prostate
COSM2874656	c.847C>T	p.L283L	Substitution - coding silent	Large_intestine
COSM5979538	c.1861G>T	p.V621L	Substitution - Missense	Upper_aerodigestive_tract
COSM1101404	c.4035A>G	p.P1345P	Substitution - coding silent	Endometrium
COSM1101416	c.2361G>T	p.E787D	Substitution - Missense	Endometrium
COSM2874576	c.3536C>T	p.T1179M	Substitution - Missense	Stomach
COSM1552795	c.1633G>T	p.G545W	Substitution - Missense	Lung

> Text Mining based Variations

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PMID	Variation	Cancer	Evidence
27633981	mutation	Angiofibroma	The t(5;8;17)(p15;q13;q21) threeway chromosomal translocation targeted AHRR (on 5p15), NCOA2 (on 8q13), and ETV4 (on 17q21) generating the inframe fusions AHRRNCOA2 and NCOA2ETV4 aswellas an outofframe ETV4AHRR transcript.
26854485	mutation	Acute Myeloid Leukemia	The MOZ-TIF2 translocation, which fuses monocytic leukemia zinc finger protein (MOZ) histone acetyltransferase (HAT) with the nuclear co-activator TIF2, is associated with the development of acute myeloid leukemia.
26845637	mutation	Angiofibroma	The AHRR-NCOA2 fusion gene was detected in eight cases, and NCOA2 gene rearrangement in nine cases.
26501226	mutation	Spindle Cell Rhabdomyosarcoma	Ten of the 11 congenital/infantile SRMS showed recurrent fusion genes: with novel VGLL2 rearrangements seen in 7 (63%), including VGLL2-CITED2 fusion in 4 and VGLL2-NCOA2 in 2 cases.
25823027	underexpression (mutation)	Colorectal Carcinoma	This chimeric LACTB2-NCOA2 transcript was detected in 6 out of 99 (6.1%) colorectal cancer (CRC) cases, where NCOA2 was significantly downregulated.
25336010	mutation	Mesenchymal Chondrosarcoma	Recently, a tumor-specific HEY1-NCOA2 fusion gene was identified in MC.
24213582	mutation	Embryonal Rhabdomyosarcoma	We analyzed a complex chromosomal translocation in a case of embryonal rhabdomyosarcoma (RMS) and showed that it generates the fusion gene PAX3 (paired box 3)-NCOA2 (nuclear receptor coactivator 2).
24124145	mutation	Mesenchymal Chondrosarcoma	HEY1-NCOA2 fusion transcript was detected in all six cases of mesenchymal chondrosarcoma but in none of the meningeal HPC cases (0/11) that were evaluable with RT-PCR.
23463663	mutation	Spindle Cell Rhabdomyosarcoma	NCOA2 rearrangements were found in two additional spindle cell RMS from a 3-month-old and a 4-week-old child.
23252872	mutation	Mesenchymal Chondrosarcoma	A tumor specific fusion gene, HEY1-NCOA2 fusion, was recently identified in this tumor.
22876322	mutation	Endometrial Carcinoma	No significant association was observed for any individual SNPs or genes, but a marginal association of the cumulative genetic variation of the NCOA2 complex as a whole (NCOA2, CARM1, CREBBP, PRMT1 and EP300) with endometrial cancer risk was observed (P(adjusted) = 0.033).
22373549	mutation	Acute Lymphoblastic Leukemia	ETV6-RUNX1 were observed in six cases (3.4%), ETV6-JAK2 in three cases (1.7%), ETV6-ABL1 in two cases (1.1%), and ETV6-ABL2, ETV6-NCOA2, ETV6-SYK, and PAX5-ETV6 each in one case (0.6%).
22337624	mutation	Angiofibroma	RT-PCR revealed in-frame AHRR/NCOA2 and NCOA2/AHHR transcripts in all four cases.
22034177	mutation	Mesenchymal Chondrosarcoma	RT-PCR or FISH evidence of this HEY1-NCOA2 fusion was present in all additional mesenchymal chondrosarcomas tested with a definitive histologic diagnosis and adequate material for analysis (n = 9) but was absent in 15 samples of other subtypes of chondrosarcomas.
19953635	mutation	Rhabdomyosarcoma	In this study, cytogenetic and/or molecular characterization to include FISH, reverse transcription polymerase chain reaction (RT-PCR), and sequencing analyses of five rhabdomyosarcomas [four ARMS and one embryonal rhabdomyosarcoma (ERMS)] with novel, recurrent t(2;2)(p23;q35) or t(2;8)(q35;q13) revealed that these noncanonical translocations fuse PAX3 to NCOA1 or NCOA2, respectively.
18754862	mutation	Acute Myeloid Leukemia	The protein MOZ (monocytic leukemia zinc finger protein) is a Myst (MOZ, Ybf2 (Sas3), Sas2, Tip60)-type histone acetyltranseferase (HAT) that generates fusion genes, such as MOZ-TIF2, MOZ-CBP and MOZ-p300, in acute myeloid leukemia (AML) by chromosomal translocation.
18281529	mutation	Childhood Leukemia	We have identified a novel recurrent t(8;12)(q13;p13), which results in a fusion between the transcriptional repressor ETV6 (TEL) and the transcriptional coactivator NCOA2 (TIF2) in six cases of childhood leukemia expressing both T-lymphoid and myeloid antigens.
17805042	mutation	Childhood Acute Myeloid Leukemia	To our knowledge, this is the eighth overall and the fourth childhood case of acute myeloid leukemia with inv(8) (p11q13) with MOZ-TIF2 fusion.
12676584	mutation	Acute Myeloid Leukemia	The MOZ-TIF2 fusion is associated with acute myeloid leukemia (AML) with inv(8)(p11q13).
10459350	mutation	Acute Myeloid Leukemia	We have recently cloned the inv(8)(p11q13) in a patient with acute myeloid leukemia (AML), and demonstrated a fusion between the MOZ and TIF2 genes at 8p11 and 8q13, respectively.
27283500	mutation	Thyroid Gland Follicular Carcinoma	New somatic alterations were identified in oncogenes (MDM2, FLI1), transcription factors and repressors (MITF, FLI1, ZNF331), epigenetic enzymes (KMT2A, NSD1, NCOA1, NCOA2), and protein kinases (JAK3, CHEK2, ALK).

Summary
Symbol	NCOA2
Name	nuclear receptor coactivator 2
Aliases	TIF2; NCoA-2; KAT13C; bHLHe75; class E basic helix-loop-helix protein 75; glucocorticoid receptor-interactin ......
Location	8q13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

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Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
Q15596	29	S	Phosphoserine	-	Yes	p.S29S (cancer: PRAD)
Q15596	338	R	Asymmetric dimethylarginine	-	No	None detected
Q15596	487	S	Phosphoserine	-	No	None detected
Q15596	493	S	Phosphoserine	-	No	None detected
Q15596	499	S	Phosphoserine	-	No	None detected
Q15596	554	S	Phosphoserine	-	No	None detected
Q15596	565	S	Phosphoserine	-	Yes	p.S565F (cancer: BLCA, SKCM)
Q15596	636	K	N6-acetyllysine	-	No	None detected
Q15596	640	K	N6-acetyllysine	-	No	None detected
Q15596	682	S	Phosphoserine	-	No	None detected
Q15596	699	S	Phosphoserine	-	No	None detected
Q15596	736	S	Phosphoserine	-	No	None detected
Q15596	771	S	Phosphoserine	-	No	None detected
Q15596	780	K	N6-acetyllysine	-	No	None detected
Q15596	785	K	N6-acetyllysine	-	No	None detected
Q15596	864	R	Asymmetric dimethylarginine	-	No	None detected
Q15596	874	R	Asymmetric dimethylarginine	-	Yes	p.R874* (cancer: GBM)
Q15596	1173	R	Asymmetric dimethylarginine	-	No	None detected
Q15596	1177	R	Asymmetric dimethylarginine	-	No	None detected
Q15596	1190	R	Asymmetric dimethylarginine	-	No	None detected
Q15596	1196	R	Asymmetric dimethylarginine	-	No	None detected
Q15596	1203	R	Asymmetric dimethylarginine	-	Yes	p.R1203C (cancer: COAD)
Q15596	1221	R	Asymmetric dimethylarginine	-	No	None detected
Q15596	1240	R	Asymmetric dimethylarginine	-	No	None detected
Q15596	1261	R	Omega-N-methylarginine	-	Yes	p.R1261Q (cancer: SKCM, UCEC)
Q15596	1266	R	Asymmetric dimethylarginine	-	No	None detected

Summary
Symbol	NCOA2
Name	nuclear receptor coactivator 2
Aliases	TIF2; NCoA-2; KAT13C; bHLHe75; class E basic helix-loop-helix protein 75; glucocorticoid receptor-interactin ......
Location	8q13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

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Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	4.565	3.806	-0.922	0.0387	Under
BRCA	Breast invasive carcinoma	112	1100	5.791	5.471	-0.421	0.00715	NS
CESC	Cervical and endocervical cancers	3	306	3.514	3.894	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	5.221	4.441	-0.748	3.37e-09	Under
ESCA	Esophageal carcinoma	11	185	5.759	5.612	-0.34	0.263	NS
GBM	Glioblastoma multiforme	5	166	5.171	3.849	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	5.117	4.434	-0.747	0.00507	Under
KIRC	Kidney renal clear cell carcinoma	72	534	5.963	5.024	-1.146	3.51e-14	Under
KIRP	Kidney renal papillary cell carcinoma	32	291	5.634	4.397	-1.615	1.73e-05	Under
LAML	Acute Myeloid Leukemia	0	173	NA	6.488	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	5.017	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	4.367	4.039	-0.531	0.0995	NS
LUAD	Lung adenocarcinoma	59	517	4.831	4.879	0.007	0.962	NS
LUSC	Lung squamous cell carcinoma	51	501	4.927	4.583	-0.43	0.00104	NS
OV	Ovarian serous cystadenocarcinoma	0	307	NA	5.318	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	4.163	4.325	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	3.89	3.927	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	5.511	4.955	-0.731	0.0088	Under
READ	Rectum adenocarcinoma	10	167	5.154	4.55	-0.632	0.0493	Under
SARC	Sarcoma	2	263	2.016	3.761	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	3.526	4.383	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	5.682	5.684	-0.161	0.342	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	4.996	NA	NA	NA
THCA	Thyroid carcinoma	59	509	4.888	4.535	-0.366	0.102	NS
THYM	Thymoma	2	120	4.547	2.547	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	4.039	3.611	-0.533	0.0726	NS

> Cancer Cell Line Encyclopedia (CCLE)

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Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	6.2
Autonomic ganglia	CHP212	5.1
Autonomic ganglia	IMR32	5.6
Autonomic ganglia	KELLY	5.6
Autonomic ganglia	KPNRTBM1	6
Autonomic ganglia	KPNSI9S	5
Autonomic ganglia	KPNYN	4.9
Autonomic ganglia	MHHNB11	6.2
Autonomic ganglia	NB1	6.1
Autonomic ganglia	NH6	5.4
Autonomic ganglia	SHSY5Y	5.8
Autonomic ganglia	SIMA	5.5
Autonomic ganglia	SKNAS	5.1
Autonomic ganglia	SKNBE2	5.5
Autonomic ganglia	SKNDZ	5.7
Autonomic ganglia	SKNFI	5.6
Autonomic ganglia	SKNSH	4.7
Biliary tract	HUCCT1	5
Biliary tract	HUH28	5.2
Biliary tract	SNU1079	6
Biliary tract	SNU1196	5.6
Biliary tract	SNU245	6.5
Biliary tract	SNU308	5.4
Biliary tract	SNU478	4.8
Bone	143B	4.7
Bone	A673	5.8
Bone	CADOES1	8.6
Bone	CAL78	5.1
Bone	G292CLONEA141B1	4.9
Bone	HOS	4.5
Bone	HS706T	4.9
Bone	HS737T	4.6
Bone	HS819T	4.8
Bone	HS821T	5.6
Bone	HS822T	5.1
Bone	HS863T	5.4
Bone	HS870T	4.2
Bone	HS888T	5.7
Bone	MG63	5
Bone	MHHES1	5.9
Bone	OUMS27	4.7
Bone	RDES	6
Bone	SJSA1	4.7
Bone	SKES1	6.5
Bone	SKNMC	7
Bone	SW1353	4.6
Bone	T173	4.8
Bone	TC71	4.5
Bone	U2OS	5.8
Breast	AU565	5.6
Breast	BT20	6.4
Breast	BT474	6.5
Breast	BT483	7.2
Breast	BT549	5.4
Breast	CAL120	5.9
Breast	CAL148	6.4
Breast	CAL51	6.2
Breast	CAL851	4.6
Breast	CAMA1	6.6
Breast	DU4475	4.8
Breast	EFM192A	4.7
Breast	EFM19	4.3
Breast	EVSAT	6.8
Breast	HCC1143	5.9
Breast	HCC1187	6.3
Breast	HCC1395	5.4
Breast	HCC1419	7.1
Breast	HCC1428	7.8
Breast	HCC1500	6.3
Breast	HCC1569	7.7
Breast	HCC1599	5.9
Breast	HCC1806	4.8
Breast	HCC1937	6.2
Breast	HCC1954	5.2
Breast	HCC202	5.3
Breast	HCC2157	5.6
Breast	HCC2218	5.9
Breast	HCC38	5.5
Breast	HCC70	6.1
Breast	HDQP1	5.6
Breast	HMC18	5.2
Breast	HS274T	5.6
Breast	HS281T	5.4
Breast	HS343T	5.6
Breast	HS578T	6
Breast	HS606T	4.8
Breast	HS739T	4.7
Breast	HS742T	5
Breast	JIMT1	6.3
Breast	KPL1	5.4
Breast	MCF7	5.8
Breast	MDAMB134VI	6
Breast	MDAMB157	5.6
Breast	MDAMB175VII	6.1
Breast	MDAMB231	4.2
Breast	MDAMB361	5.6
Breast	MDAMB415	4.3
Breast	MDAMB436	5.5
Breast	MDAMB453	6.7
Breast	MDAMB468	4.9
Breast	SKBR3	5.2
Breast	T47D	5.6
Breast	UACC812	5.1
Breast	UACC893	7.1
Breast	YMB1	5.7
Breast	ZR751	5.5
Breast	ZR7530	7.8
Central nervous system	1321N1	5.2
Central nervous system	42MGBA	4.9
Central nervous system	8MGBA	6
Central nervous system	A172	4.4
Central nervous system	AM38	4.5
Central nervous system	BECKER	4.8
Central nervous system	CAS1	4.5
Central nervous system	CCFSTTG1	4.9
Central nervous system	D283MED	5.2
Central nervous system	D341MED	5.2
Central nervous system	DAOY	4.7
Central nervous system	DBTRG05MG	4.4
Central nervous system	DKMG	4.5
Central nervous system	GAMG	4.9
Central nervous system	GB1	4.3
Central nervous system	GI1	5.3
Central nervous system	GMS10	6.2
Central nervous system	GOS3	5
Central nervous system	H4	5.4
Central nervous system	HS683	4.6
Central nervous system	KALS1	4.8
Central nervous system	KG1C	4.5
Central nervous system	KNS42	4.8
Central nervous system	KNS60	4.9
Central nervous system	KNS81	4.8
Central nervous system	KS1	5.4
Central nervous system	LN18	4.7
Central nervous system	LN229	4.7
Central nervous system	M059K	4.4
Central nervous system	MOGGCCM	4.7
Central nervous system	MOGGUVW	4.5
Central nervous system	NMCG1	4.8
Central nervous system	ONS76	4.7
Central nervous system	SF126	4.6
Central nervous system	SF295	4.6
Central nervous system	SNB19	4.9
Central nervous system	SNU1105	4.9
Central nervous system	SNU201	5.4
Central nervous system	SNU466	5.2
Central nervous system	SNU489	5
Central nervous system	SNU626	4.5
Central nervous system	SNU738	5.3
Central nervous system	SW1088	4.7
Central nervous system	SW1783	4.5
Central nervous system	T98G	5.2
Central nervous system	TM31	6
Central nervous system	U118MG	5.3
Central nervous system	U138MG	5
Central nervous system	U251MG	5.2
Central nervous system	U87MG	4.8
Central nervous system	YH13	5.1
Central nervous system	YKG1	5.3
Endometrium	AN3CA	5.2
Endometrium	COLO684	5.8
Endometrium	EFE184	4.8
Endometrium	EN	5.7
Endometrium	ESS1	4.9
Endometrium	HEC108	5.6
Endometrium	HEC151	4.4
Endometrium	HEC1A	5.4
Endometrium	HEC1B	5.7
Endometrium	HEC251	4.9
Endometrium	HEC265	4.5
Endometrium	HEC50B	5.2
Endometrium	HEC59	8
Endometrium	HEC6	5.2
Endometrium	ISHIKAWAHERAKLIO02ER	4.5
Endometrium	JHUEM1	5.9
Endometrium	JHUEM2	4.9
Endometrium	JHUEM3	5.7
Endometrium	KLE	3.9
Endometrium	MFE280	5.2
Endometrium	MFE296	5.1
Endometrium	MFE319	4.4
Endometrium	RL952	5.5
Endometrium	SNGM	4.8
Endometrium	SNU1077	5.5
Endometrium	SNU685	5.5
Endometrium	TEN	5.9
Haematopoietic and lymphoid	697	7.3
Haematopoietic and lymphoid	A3KAW	5.7
Haematopoietic and lymphoid	A4FUK	6.4
Haematopoietic and lymphoid	ALLSIL	6.8
Haematopoietic and lymphoid	AML193	5.1
Haematopoietic and lymphoid	AMO1	7.2
Haematopoietic and lymphoid	BCP1	7.1
Haematopoietic and lymphoid	BDCM	5.6
Haematopoietic and lymphoid	BL41	5.4
Haematopoietic and lymphoid	BL70	5.4
Haematopoietic and lymphoid	BV173	7.1
Haematopoietic and lymphoid	CA46	6.5
Haematopoietic and lymphoid	CI1	5.3
Haematopoietic and lymphoid	CMK115	6.1
Haematopoietic and lymphoid	CMK86	6.2
Haematopoietic and lymphoid	CMK	6.1
Haematopoietic and lymphoid	CMLT1	6.4
Haematopoietic and lymphoid	COLO775	5.7
Haematopoietic and lymphoid	DAUDI	6.2
Haematopoietic and lymphoid	DB	4
Haematopoietic and lymphoid	DEL	5.6
Haematopoietic and lymphoid	DND41	6.1
Haematopoietic and lymphoid	DOHH2	6.2
Haematopoietic and lymphoid	EB1	6.1
Haematopoietic and lymphoid	EB2	6
Haematopoietic and lymphoid	EHEB	6.1
Haematopoietic and lymphoid	EJM	7
Haematopoietic and lymphoid	EM2	6.2
Haematopoietic and lymphoid	EOL1	6.6
Haematopoietic and lymphoid	F36P	6.5
Haematopoietic and lymphoid	GA10	5.6
Haematopoietic and lymphoid	GDM1	6.7
Haematopoietic and lymphoid	GRANTA519	6.7
Haematopoietic and lymphoid	HDLM2	7.1
Haematopoietic and lymphoid	HDMYZ	4.4
Haematopoietic and lymphoid	HEL9217	5.8
Haematopoietic and lymphoid	HEL	6
Haematopoietic and lymphoid	HH	7.2
Haematopoietic and lymphoid	HL60	5.1
Haematopoietic and lymphoid	HPBALL	5.1
Haematopoietic and lymphoid	HS604T	5.3
Haematopoietic and lymphoid	HS611T	6.4
Haematopoietic and lymphoid	HS616T	4.6
Haematopoietic and lymphoid	HS751T	4.8
Haematopoietic and lymphoid	HT	6.9
Haematopoietic and lymphoid	HTK	5.6
Haematopoietic and lymphoid	HUNS1	5.4
Haematopoietic and lymphoid	HUT102	6.7
Haematopoietic and lymphoid	HUT78	5.1
Haematopoietic and lymphoid	JEKO1	5
Haematopoietic and lymphoid	JK1	6.7
Haematopoietic and lymphoid	JM1	5.6
Haematopoietic and lymphoid	JURKAT	6.1
Haematopoietic and lymphoid	JURLMK1	5.4
Haematopoietic and lymphoid	JVM2	6.6
Haematopoietic and lymphoid	JVM3	6.5
Haematopoietic and lymphoid	K562	4.5
Haematopoietic and lymphoid	KARPAS299	5.6
Haematopoietic and lymphoid	KARPAS422	4.6
Haematopoietic and lymphoid	KARPAS620	6.7
Haematopoietic and lymphoid	KASUMI1	5.3
Haematopoietic and lymphoid	KASUMI2	6.4
Haematopoietic and lymphoid	KASUMI6	6.1
Haematopoietic and lymphoid	KCL22	7.4
Haematopoietic and lymphoid	KE37	6.6
Haematopoietic and lymphoid	KE97	6
Haematopoietic and lymphoid	KG1	6.8
Haematopoietic and lymphoid	KHM1B	6.3
Haematopoietic and lymphoid	KIJK	5.2
Haematopoietic and lymphoid	KMH2	4.8
Haematopoietic and lymphoid	KMM1	5.9
Haematopoietic and lymphoid	KMS11	5.5
Haematopoietic and lymphoid	KMS12BM	6.5
Haematopoietic and lymphoid	KMS18	7
Haematopoietic and lymphoid	KMS20	6.7
Haematopoietic and lymphoid	KMS21BM	5.8
Haematopoietic and lymphoid	KMS26	6.5
Haematopoietic and lymphoid	KMS27	5.8
Haematopoietic and lymphoid	KMS28BM	7
Haematopoietic and lymphoid	KMS34	7.1
Haematopoietic and lymphoid	KO52	6.3
Haematopoietic and lymphoid	KOPN8	6.3
Haematopoietic and lymphoid	KU812	6.7
Haematopoietic and lymphoid	KYO1	5.8
Haematopoietic and lymphoid	L1236	5.6
Haematopoietic and lymphoid	L363	7.8
Haematopoietic and lymphoid	L428	7.4
Haematopoietic and lymphoid	L540	6.2
Haematopoietic and lymphoid	LAMA84	6.6
Haematopoietic and lymphoid	LOUCY	5.8
Haematopoietic and lymphoid	LP1	6.6
Haematopoietic and lymphoid	M07E	6.4
Haematopoietic and lymphoid	MC116	6
Haematopoietic and lymphoid	ME1	4.7
Haematopoietic and lymphoid	MEC1	7.1
Haematopoietic and lymphoid	MEC2	6.4
Haematopoietic and lymphoid	MEG01	5.5
Haematopoietic and lymphoid	MHHCALL2	6.6
Haematopoietic and lymphoid	MHHCALL3	6.4
Haematopoietic and lymphoid	MHHCALL4	6.4
Haematopoietic and lymphoid	MINO	5.8
Haematopoietic and lymphoid	MJ	7
Haematopoietic and lymphoid	MM1S	5.9
Haematopoietic and lymphoid	MOLM13	6.6
Haematopoietic and lymphoid	MOLM16	6.8
Haematopoietic and lymphoid	MOLM6	5.9
Haematopoietic and lymphoid	MOLP2	5.9
Haematopoietic and lymphoid	MOLP8	7.3
Haematopoietic and lymphoid	MOLT13	6.7
Haematopoietic and lymphoid	MOLT16	6
Haematopoietic and lymphoid	MOLT4	5.9
Haematopoietic and lymphoid	MONOMAC1	6.4
Haematopoietic and lymphoid	MONOMAC6	6.3
Haematopoietic and lymphoid	MOTN1	6.3
Haematopoietic and lymphoid	MUTZ5	6.4
Haematopoietic and lymphoid	MV411	5.1
Haematopoietic and lymphoid	NALM19	7
Haematopoietic and lymphoid	NALM1	6.5
Haematopoietic and lymphoid	NALM6	6.1
Haematopoietic and lymphoid	NAMALWA	6.1
Haematopoietic and lymphoid	NB4	5.7
Haematopoietic and lymphoid	NCIH929	6
Haematopoietic and lymphoid	NCO2	6.1
Haematopoietic and lymphoid	NOMO1	7.1
Haematopoietic and lymphoid	NUDHL1	5.3
Haematopoietic and lymphoid	NUDUL1	6.6
Haematopoietic and lymphoid	OCIAML2	6.2
Haematopoietic and lymphoid	OCIAML3	6.2
Haematopoietic and lymphoid	OCIAML5	6.6
Haematopoietic and lymphoid	OCILY10	4.4
Haematopoietic and lymphoid	OCILY19	6
Haematopoietic and lymphoid	OCILY3	4.5
Haematopoietic and lymphoid	OCIM1	7.7
Haematopoietic and lymphoid	OPM2	7.7
Haematopoietic and lymphoid	P12ICHIKAWA	6.3
Haematopoietic and lymphoid	P31FUJ	5.3
Haematopoietic and lymphoid	P3HR1	5.6
Haematopoietic and lymphoid	PCM6	6.3
Haematopoietic and lymphoid	PEER	5.3
Haematopoietic and lymphoid	PF382	6
Haematopoietic and lymphoid	PFEIFFER	8.4
Haematopoietic and lymphoid	PL21	6.4
Haematopoietic and lymphoid	RAJI	5.2
Haematopoietic and lymphoid	RCHACV	7.6
Haematopoietic and lymphoid	REC1	6.1
Haematopoietic and lymphoid	REH	5.6
Haematopoietic and lymphoid	RI1	5.5
Haematopoietic and lymphoid	RL	5.6
Haematopoietic and lymphoid	RPMI8226	5.3
Haematopoietic and lymphoid	RPMI8402	5.9
Haematopoietic and lymphoid	RS411	6.3
Haematopoietic and lymphoid	SEM	6.1
Haematopoietic and lymphoid	SET2	6.4
Haematopoietic and lymphoid	SIGM5	6.3
Haematopoietic and lymphoid	SKM1	5.9
Haematopoietic and lymphoid	SKMM2	7.1
Haematopoietic and lymphoid	SR786	7.7
Haematopoietic and lymphoid	ST486	6
Haematopoietic and lymphoid	SUDHL10	6.1
Haematopoietic and lymphoid	SUDHL1	5
Haematopoietic and lymphoid	SUDHL4	4.9
Haematopoietic and lymphoid	SUDHL5	6.5
Haematopoietic and lymphoid	SUDHL6	6.4
Haematopoietic and lymphoid	SUDHL8	6.9
Haematopoietic and lymphoid	SUPB15	7
Haematopoietic and lymphoid	SUPHD1	6.7
Haematopoietic and lymphoid	SUPM2	5.7
Haematopoietic and lymphoid	SUPT11	6.8
Haematopoietic and lymphoid	SUPT1	5.1
Haematopoietic and lymphoid	TALL1	6.3
Haematopoietic and lymphoid	TF1	5.9
Haematopoietic and lymphoid	THP1	5.7
Haematopoietic and lymphoid	TO175T	5
Haematopoietic and lymphoid	TOLEDO	6.5
Haematopoietic and lymphoid	U266B1	5.8
Haematopoietic and lymphoid	U937	5.1
Haematopoietic and lymphoid	UT7	6.4
Haematopoietic and lymphoid	WSUDLCL2	6.6
Kidney	769P	5.3
Kidney	786O	5.4
Kidney	A498	5.9
Kidney	A704	4.4
Kidney	ACHN	4.7
Kidney	BFTC909	6.5
Kidney	CAKI1	5.2
Kidney	CAKI2	5
Kidney	CAL54	5.5
Kidney	KMRC1	5.8
Kidney	KMRC20	5.2
Kidney	KMRC2	4.7
Kidney	KMRC3	4.9
Kidney	OSRC2	4.5
Kidney	RCC10RGB	5
Kidney	SNU1272	5
Kidney	SNU349	4.9
Kidney	TUHR10TKB	5.2
Kidney	TUHR14TKB	5.8
Kidney	TUHR4TKB	4.4
Kidney	VMRCRCW	5.2
Kidney	VMRCRCZ	5.9
Large intestine	C2BBE1	5.5
Large intestine	CCK81	5
Large intestine	CL11	6.1
Large intestine	CL14	4.7
Large intestine	CL34	6.1
Large intestine	CL40	5.2
Large intestine	COLO205	4.9
Large intestine	COLO320	5.4
Large intestine	COLO678	5.8
Large intestine	CW2	4.9
Large intestine	DLD1	5.2
Large intestine	GP2D	4.8
Large intestine	HCC56	4.6
Large intestine	HCT116	5.1
Large intestine	HCT15	4.7
Large intestine	HS675T	4.9
Large intestine	HS698T	5
Large intestine	HT115	5
Large intestine	HT29	5.3
Large intestine	HT55	5.6
Large intestine	KM12	5.3
Large intestine	LOVO	5
Large intestine	LS1034	5.2
Large intestine	LS123	4.9
Large intestine	LS180	5.2
Large intestine	LS411N	5.9
Large intestine	LS513	4.7
Large intestine	MDST8	4.6
Large intestine	NCIH508	4.7
Large intestine	NCIH716	5.9
Large intestine	NCIH747	5.4
Large intestine	OUMS23	5.1
Large intestine	RCM1	5.3
Large intestine	RKO	5.1
Large intestine	SKCO1	4.9
Large intestine	SNU1040	5.3
Large intestine	SNU1197	4.6
Large intestine	SNU175	5.7
Large intestine	SNU283	5.9
Large intestine	SNU407	5.5
Large intestine	SNU503	5.1
Large intestine	SNU61	5.2
Large intestine	SNU81	6.4
Large intestine	SNUC1	5.1
Large intestine	SNUC2A	5.8
Large intestine	SNUC4	5.5
Large intestine	SNUC5	4.6
Large intestine	SW1116	5
Large intestine	SW1417	4.6
Large intestine	SW1463	5.1
Large intestine	SW403	5.5
Large intestine	SW480	4.3
Large intestine	SW48	4.8
Large intestine	SW620	5.2
Large intestine	SW837	5.3
Large intestine	SW948	5.2
Large intestine	T84	5
Liver	ALEXANDERCELLS	4.9
Liver	C3A	5.5
Liver	HEP3B217	6.7
Liver	HEPG2	5.9
Liver	HLE	5.1
Liver	HLF	4.4
Liver	HUH1	5.9
Liver	HUH6	5.6
Liver	HUH7	7.1
Liver	JHH1	5.2
Liver	JHH2	5.6
Liver	JHH4	4.4
Liver	JHH5	6
Liver	JHH6	4.6
Liver	JHH7	5.1
Liver	LI7	5.7
Liver	PLCPRF5	4.8
Liver	SKHEP1	4.6
Liver	SNU182	4.5
Liver	SNU387	4.8
Liver	SNU398	6.2
Liver	SNU423	4.6
Liver	SNU449	5.1
Liver	SNU475	6.2
Liver	SNU761	4.8
Liver	SNU878	5.5
Liver	SNU886	5.4
Lung	A549	5.1
Lung	ABC1	6.3
Lung	BEN	4.6
Lung	CAL12T	5.1
Lung	CALU1	4.7
Lung	CALU3	4.5
Lung	CALU6	5.5
Lung	CHAGOK1	4.4
Lung	COLO668	5.2
Lung	COLO699	5.9
Lung	CORL105	4.7
Lung	CORL23	4.6
Lung	CORL24	5.7
Lung	CORL279	6
Lung	CORL311	4.8
Lung	CORL47	4.7
Lung	CORL51	5.3
Lung	CORL88	5.1
Lung	CORL95	4.9
Lung	CPCN	5
Lung	DMS114	5.8
Lung	DMS153	4.8
Lung	DMS273	4.4
Lung	DMS454	4.9
Lung	DMS53	4.4
Lung	DMS79	5
Lung	DV90	4.9
Lung	EBC1	5
Lung	EPLC272H	4.7
Lung	HARA	5.3
Lung	HCC1171	6.1
Lung	HCC1195	6.2
Lung	HCC15	4.8
Lung	HCC2279	5.9
Lung	HCC2935	5.6
Lung	HCC33	5.9
Lung	HCC366	4.7
Lung	HCC4006	5.1
Lung	HCC44	4.3
Lung	HCC78	4.8
Lung	HCC827	5.5
Lung	HCC95	4.5
Lung	HLC1	5.4
Lung	HLFA	5.5
Lung	HS229T	4.5
Lung	HS618T	5
Lung	IALM	5.4
Lung	KNS62	4.8
Lung	LC1F	5.9
Lung	LC1SQSF	5.6
Lung	LCLC103H	5.7
Lung	LCLC97TM1	6.4
Lung	LK2	5.7
Lung	LOUNH91	4.5
Lung	LU65	4.3
Lung	LU99	5.5
Lung	LUDLU1	4.7
Lung	LXF289	5.2
Lung	MORCPR	6.3
Lung	NCIH1048	5.1
Lung	NCIH1092	4.8
Lung	NCIH1105	5.7
Lung	NCIH1155	5.4
Lung	NCIH1184	5.2
Lung	NCIH1299	5.9
Lung	NCIH1339	5.5
Lung	NCIH1341	7
Lung	NCIH1355	5.1
Lung	NCIH1373	4.8
Lung	NCIH1385	5.9
Lung	NCIH1395	5.7
Lung	NCIH1435	7.3
Lung	NCIH1436	5.2
Lung	NCIH1437	5.4
Lung	NCIH146	6
Lung	NCIH1563	6
Lung	NCIH1568	6.3
Lung	NCIH1573	5.6
Lung	NCIH1581	6.8
Lung	NCIH1618	5.2
Lung	NCIH1623	5.7
Lung	NCIH1648	5.2
Lung	NCIH1650	6
Lung	NCIH1651	5.7
Lung	NCIH1666	4.8
Lung	NCIH1693	5
Lung	NCIH1694	5.2
Lung	NCIH1703	5.6
Lung	NCIH1734	5.4
Lung	NCIH1755	5
Lung	NCIH1781	5.3
Lung	NCIH1792	4.8
Lung	NCIH1793	5.7
Lung	NCIH1836	5.7
Lung	NCIH1838	4.7
Lung	NCIH1869	5.5
Lung	NCIH1876	5.5
Lung	NCIH1915	4.9
Lung	NCIH1930	5.6
Lung	NCIH1944	6.1
Lung	NCIH1963	5.1
Lung	NCIH196	6.8
Lung	NCIH1975	5.7
Lung	NCIH2009	6
Lung	NCIH2023	4.9
Lung	NCIH2029	6.1
Lung	NCIH2030	6.1
Lung	NCIH2066	5.2
Lung	NCIH2081	5.3
Lung	NCIH2085	5.2
Lung	NCIH2087	5.1
Lung	NCIH209	5.7
Lung	NCIH2106	4.7
Lung	NCIH2110	5.3
Lung	NCIH211	5.1
Lung	NCIH2122	5.7
Lung	NCIH2126	4.9
Lung	NCIH2141	6.2
Lung	NCIH2170	5.5
Lung	NCIH2171	4.7
Lung	NCIH2172	5
Lung	NCIH2196	5.4
Lung	NCIH2227	4.3
Lung	NCIH2228	4.9
Lung	NCIH226	4.8
Lung	NCIH2286	4.8
Lung	NCIH2291	5
Lung	NCIH2342	5.6
Lung	NCIH2347	4.8
Lung	NCIH23	4.1
Lung	NCIH2405	6
Lung	NCIH2444	5
Lung	NCIH292	4.9
Lung	NCIH322	4.8
Lung	NCIH3255	6.3
Lung	NCIH358	5.5
Lung	NCIH441	6.1
Lung	NCIH446	6.1
Lung	NCIH460	4.5
Lung	NCIH510	4.5
Lung	NCIH520	5.3
Lung	NCIH522	5.3
Lung	NCIH524	4.3
Lung	NCIH526	5.1
Lung	NCIH596	5.8
Lung	NCIH647	4.7
Lung	NCIH650	5.1
Lung	NCIH661	5.4
Lung	NCIH69	6.7
Lung	NCIH727	6
Lung	NCIH810	4.8
Lung	NCIH82	5.6
Lung	NCIH838	5.4
Lung	NCIH841	5.3
Lung	NCIH854	5.4
Lung	NCIH889	7.2
Lung	PC14	4.1
Lung	RERFLCAD1	6.6
Lung	RERFLCAD2	4.7
Lung	RERFLCAI	5
Lung	RERFLCKJ	4.8
Lung	RERFLCMS	4.7
Lung	RERFLCSQ1	5.2
Lung	SBC5	5.5
Lung	SCLC21H	6.8
Lung	SHP77	5.8
Lung	SKLU1	4.9
Lung	SKMES1	4.5
Lung	SQ1	5
Lung	SW1271	5.6
Lung	SW1573	5.3
Lung	SW900	4.8
Lung	VMRCLCD	4.6
Lung	VMRCLCP	5.4
Oesophagus	COLO680N	4.8
Oesophagus	ECGI10	4.9
Oesophagus	KYSE140	4.7
Oesophagus	KYSE150	5
Oesophagus	KYSE180	4.7
Oesophagus	KYSE270	5.3
Oesophagus	KYSE30	6.4
Oesophagus	KYSE410	4.6
Oesophagus	KYSE450	5
Oesophagus	KYSE510	5.4
Oesophagus	KYSE520	5.1
Oesophagus	KYSE70	4.8
Oesophagus	OE19	6
Oesophagus	OE33	5
Oesophagus	TE10	4.7
Oesophagus	TE11	5.1
Oesophagus	TE14	5.9
Oesophagus	TE15	4.5
Oesophagus	TE1	4.7
Oesophagus	TE4	5.6
Oesophagus	TE5	4.5
Oesophagus	TE6	6.7
Oesophagus	TE8	5
Oesophagus	TE9	6
Oesophagus	TT	4.9
Ovary	59M	5
Ovary	A2780	6.3
Ovary	CAOV3	6
Ovary	CAOV4	4.7
Ovary	COLO704	4.7
Ovary	COV318	4.4
Ovary	COV362	4.7
Ovary	COV434	4.9
Ovary	COV504	5.4
Ovary	COV644	4.9
Ovary	EFO21	4.2
Ovary	EFO27	4.5
Ovary	ES2	5.2
Ovary	FUOV1	4.9
Ovary	HEYA8	5.4
Ovary	HS571T	4.7
Ovary	IGROV1	5.5
Ovary	JHOC5	5.9
Ovary	JHOM1	5.7
Ovary	JHOM2B	6.6
Ovary	JHOS2	5.2
Ovary	JHOS4	5.9
Ovary	KURAMOCHI	7.1
Ovary	MCAS	4.9
Ovary	NIHOVCAR3	6
Ovary	OAW28	5.6
Ovary	OAW42	5.4
Ovary	OC314	4.7
Ovary	OC316	4.7
Ovary	ONCODG1	5.7
Ovary	OV56	5
Ovary	OV7	4.7
Ovary	OV90	4.7
Ovary	OVCAR4	5.1
Ovary	OVCAR8	5.5
Ovary	OVISE	5.9
Ovary	OVK18	5.9
Ovary	OVKATE	5.5
Ovary	OVMANA	4.8
Ovary	OVSAHO	5.5
Ovary	OVTOKO	4.8
Ovary	RMGI	4.4
Ovary	RMUGS	5.1
Ovary	SKOV3	5.3
Ovary	SNU119	7
Ovary	SNU840	6.4
Ovary	SNU8	4.9
Ovary	TOV112D	5.6
Ovary	TOV21G	5.4
Ovary	TYKNU	5.1
Pancreas	ASPC1	7
Pancreas	BXPC3	4.9
Pancreas	CAPAN1	5
Pancreas	CAPAN2	6.1
Pancreas	CFPAC1	4.5
Pancreas	DANG	4.9
Pancreas	HPAC	5.7
Pancreas	HPAFII	5.5
Pancreas	HS766T	4.6
Pancreas	HUPT3	4.7
Pancreas	HUPT4	6.1
Pancreas	KCIMOH1	6.9
Pancreas	KLM1	6
Pancreas	KP2	4.8
Pancreas	KP3	5.4
Pancreas	KP4	5
Pancreas	L33	5.1
Pancreas	MIAPACA2	4.5
Pancreas	PANC0203	5.2
Pancreas	PANC0213	5
Pancreas	PANC0327	4.6
Pancreas	PANC0403	5.2
Pancreas	PANC0504	4.2
Pancreas	PANC0813	5.7
Pancreas	PANC1005	6.1
Pancreas	PANC1	4.9
Pancreas	PATU8902	5.5
Pancreas	PATU8988S	5.9
Pancreas	PATU8988T	5
Pancreas	PK1	5.2
Pancreas	PK45H	5
Pancreas	PK59	5.4
Pancreas	PL45	5.3
Pancreas	PSN1	4.4
Pancreas	QGP1	5.5
Pancreas	SNU213	5.7
Pancreas	SNU324	5.1
Pancreas	SNU410	5.8
Pancreas	SU8686	4.9
Pancreas	SUIT2	5.3
Pancreas	SW1990	4.4
Pancreas	T3M4	4.9
Pancreas	TCCPAN2	5.8
Pancreas	YAPC	5.2
Pleura	ACCMESO1	4.7
Pleura	DM3	5
Pleura	ISTMES1	4.8
Pleura	ISTMES2	4.5
Pleura	JL1	5.7
Pleura	MPP89	4.7
Pleura	MSTO211H	4.7
Pleura	NCIH2052	5.7
Pleura	NCIH2452	4.3
Pleura	NCIH28	4.9
Prostate	22RV1	5.4
Prostate	DU145	5.4
Prostate	LNCAPCLONEFGC	6.4
Prostate	MDAPCA2B	6.8
Prostate	NCIH660	6.2
Prostate	PC3	4.8
Prostate	VCAP	7.7
Salivary gland	A253	4.6
Salivary gland	YD15	5.2
Skin	A101D	4.3
Skin	A2058	5.5
Skin	A375	4.6
Skin	C32	5.9
Skin	CHL1	6.2
Skin	CJM	5.6
Skin	COLO679	5.6
Skin	COLO741	5
Skin	COLO783	5.7
Skin	COLO792	5.1
Skin	COLO800	4.8
Skin	COLO818	5.4
Skin	COLO829	5.6
Skin	COLO849	4.9
Skin	G361	6
Skin	GRM	4.2
Skin	HMCB	6.3
Skin	HS294T	4.5
Skin	HS600T	4.9
Skin	HS688AT	5.1
Skin	HS695T	5
Skin	HS839T	5
Skin	HS852T	5.2
Skin	HS895T	4.5
Skin	HS934T	5.8
Skin	HS936T	5
Skin	HS939T	4.6
Skin	HS940T	4.6
Skin	HS944T	4.8
Skin	HT144	5
Skin	IGR1	4.9
Skin	IGR37	5
Skin	IGR39	5.2
Skin	IPC298	5.4
Skin	K029AX	5.2
Skin	LOXIMVI	5.4
Skin	MALME3M	5.6
Skin	MDAMB435S	4.9
Skin	MELHO	5.3
Skin	MELJUSO	4.5
Skin	MEWO	4.9
Skin	RPMI7951	4.8
Skin	RVH421	5
Skin	SH4	6.4
Skin	SKMEL1	5.5
Skin	SKMEL24	5
Skin	SKMEL28	5.5
Skin	SKMEL2	5.1
Skin	SKMEL30	5.7
Skin	SKMEL31	4.2
Skin	SKMEL3	5.9
Skin	SKMEL5	5.6
Skin	UACC257	4.8
Skin	UACC62	4.8
Skin	WM115	5.1
Skin	WM1799	5.4
Skin	WM2664	4.8
Skin	WM793	4.7
Skin	WM88	4.7
Skin	WM983B	5
Small intestine	HUTU80	5.3
Soft tissue	A204	5.3
Soft tissue	G401	5.7
Soft tissue	G402	4.7
Soft tissue	GCT	5.3
Soft tissue	HS729	4.8
Soft tissue	HT1080	4.3
Soft tissue	KYM1	6.3
Soft tissue	MESSA	6.2
Soft tissue	RD	5.5
Soft tissue	RH30	4.5
Soft tissue	RH41	5.3
Soft tissue	RKN	4.3
Soft tissue	S117	5.2
Soft tissue	SJRH30	5.1
Soft tissue	SKLMS1	4.7
Soft tissue	SKUT1	4.1
Soft tissue	TE125T	5.4
Soft tissue	TE159T	4.6
Soft tissue	TE441T	7.6
Soft tissue	TE617T	5.7
Stomach	2313287	5.9
Stomach	AGS	5.4
Stomach	AZ521	5.3
Stomach	ECC10	6.1
Stomach	ECC12	5.8
Stomach	FU97	5.7
Stomach	GCIY	5.4
Stomach	GSS	5.5
Stomach	GSU	6
Stomach	HGC27	7
Stomach	HS746T	5.2
Stomach	HUG1N	5.7
Stomach	IM95	5.8
Stomach	KATOIII	5
Stomach	KE39	7.4
Stomach	LMSU	6
Stomach	MKN1	4.8
Stomach	MKN45	5
Stomach	MKN74	5.4
Stomach	MKN7	5.4
Stomach	NCCSTCK140	7.6
Stomach	NCIN87	4.8
Stomach	NUGC2	4.8
Stomach	NUGC3	5.3
Stomach	NUGC4	4.9
Stomach	OCUM1	6
Stomach	RERFGC1B	6
Stomach	SH10TC	5.1
Stomach	SNU16	5.3
Stomach	SNU1	5.4
Stomach	SNU216	7
Stomach	SNU520	6.8
Stomach	SNU5	5.4
Stomach	SNU601	5.5
Stomach	SNU620	6.5
Stomach	SNU668	7
Stomach	SNU719	6.2
Stomach	TGBC11TKB	5.6
Thyroid	8305C	5.4
Thyroid	8505C	5.5
Thyroid	BCPAP	5
Thyroid	BHT101	7.4
Thyroid	CAL62	5.9
Thyroid	CGTHW1	5.1
Thyroid	FTC133	4.7
Thyroid	FTC238	4.3
Thyroid	ML1	6.9
Thyroid	SW579	4.8
Thyroid	TT2609C02	5.4
Thyroid	TT	6.1
Upper aerodigestive tract	BHY	5.1
Upper aerodigestive tract	BICR16	4.6
Upper aerodigestive tract	BICR18	5.2
Upper aerodigestive tract	BICR22	5.9
Upper aerodigestive tract	BICR31	4.9
Upper aerodigestive tract	BICR56	6.4
Upper aerodigestive tract	BICR6	5
Upper aerodigestive tract	CAL27	6.4
Upper aerodigestive tract	CAL33	6.6
Upper aerodigestive tract	DETROIT562	5.5
Upper aerodigestive tract	FADU	6.1
Upper aerodigestive tract	HS840T	4.7
Upper aerodigestive tract	HSC2	4.7
Upper aerodigestive tract	HSC3	4.7
Upper aerodigestive tract	HSC4	5.4
Upper aerodigestive tract	PECAPJ15	5.4
Upper aerodigestive tract	PECAPJ34CLONEC12	5.8
Upper aerodigestive tract	PECAPJ41CLONED2	5.3
Upper aerodigestive tract	PECAPJ49	5.2
Upper aerodigestive tract	SCC15	6.3
Upper aerodigestive tract	SCC25	5
Upper aerodigestive tract	SCC4	5.3
Upper aerodigestive tract	SCC9	5.6
Upper aerodigestive tract	SNU1076	5.6
Upper aerodigestive tract	SNU1214	5
Upper aerodigestive tract	SNU46	5.4
Upper aerodigestive tract	SNU899	5.5
Upper aerodigestive tract	YD10B	5.5
Upper aerodigestive tract	YD38	5.7
Upper aerodigestive tract	YD8	6.1
Urinary tract	5637	4.1
Urinary tract	639V	6.1
Urinary tract	647V	5.6
Urinary tract	BC3C	6.1
Urinary tract	BFTC905	5.1
Urinary tract	CAL29	5.5
Urinary tract	HS172T	5.2
Urinary tract	HT1197	5.1
Urinary tract	HT1376	6.3
Urinary tract	J82	5
Urinary tract	JMSU1	5.7
Urinary tract	KMBC2	5.7
Urinary tract	KU1919	5.6
Urinary tract	RT11284	5.1
Urinary tract	RT112	5.2
Urinary tract	RT4	5.6
Urinary tract	SCABER	5.5
Urinary tract	SW1710	5.5
Urinary tract	SW780	5.2
Urinary tract	T24	5.3
Urinary tract	TCCSUP	4.8
Urinary tract	UMUC1	5.4
Urinary tract	UMUC3	4.7
Urinary tract	VMCUB1	5.1

> The Human Protein Atlas (HPA)

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Tissue	Expression Level (TPM)
Adipose tissue	8.7
Adrenal gland	11.8
Appendix	13.6
Bone marrow	15.3
Breast	16.5
Cerebral cortex	20.3
Cervix, uterine	15.4
Colon	10.7
Duodenum	11.9
Endometrium	16.6
Epididymis	35.4
Esophagus	17
Fallopian tube	17.7
Gallbladder	14
Heart muscle	10.4
Kidney	15.6
Liver	12.3
Lung	15
Lymph node	13.6
Ovary	19.7
Pancreas	1.5
Parathyroid gland	32.3
Placenta	17.2
Prostate	20.2
Rectum	11.7
Salivary gland	4.7
Seminal vesicle	17
Skeletal muscle	2.7
Skin	12.5
Small intestine	13.5
Smooth muscle	13.1
Spleen	17.4
Stomach	10.2
Testis	27.7
Thyroid gland	20.1
Tonsil	11.9
Urinary bladder	13.5

> Text Mining based Expression

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PMID	Expression	Cancer	Evidence
24304549	overexpression	Breast Carcinoma	As the members of the p160/nuclear receptor co-activator (NCOA) family, NCOA1, NCOA2 and NCOA3 are known to be overexpressed in breast cancer and essentially involved in estrogen-mediated cancer cell proliferation we asked if these proteins are involved in the ERα-mediated transactivation of PLAC1 in breast cancer cells.
27606620	overexpression	Prostate Carcinoma	The continued activation of androgen receptor (AR) transcription and elevated expression of AR and transcriptional intermediary factor 2 (TIF2) coactivator observed in prostate cancer (CaP) recurrence and the development of castration-resistant CaP (CRPC) support a screening strategy for small-molecule inhibitors of AR-TIF2 protein-protein interactions (PPIs) to find new drug candidates.
26799514	overexpression (copy number gain)	Prostate Carcinoma	In the subset of tumors with ERG fusion genes (ERG+), five genes were identified as significantly overexpressed (false discovery rate [FDR], ≤ 5%) in tumors with relative 8q24 gain, namely VN1R1, ZNF417, CDON, IKZF2, and NCOA2.
25823027	underexpression (mutation)	Colorectal Carcinoma	This chimeric LACTB2-NCOA2 transcript was detected in 6 out of 99 (6.1%) colorectal cancer (CRC) cases, where NCOA2 was significantly downregulated.
25664849	overexpression (copy number gain)	Prostate Carcinoma	SRC-2 was highly elevated in a variety of tumors, especially in prostate cancer, in which SRC-2 was amplified and overexpressed in 37% of the metastatic tumors evaluated.
25295534	overexpression; copy number gain	Castration-Resistant Prostate Carcinoma	Here we determined that nuclear receptor coactivator 2 (NCoA2, also known as SRC-2), which is frequently amplified or overexpressed in patients with metastatic PCa, mediates development of CRPC.
19198856	overexpression	Colorectal Carcinoma	The expression of the three proteins was significantly increased in epithelial cells of carcinomas compared to normal mucosa. In carcinomas, a significant correlation between the levels of expression of AIB1 and TIF2 was noted.
18360708	underexpression	Colorectal Carcinoma	Eight genes were selected to confirm the microarray data by RT-PCR and real-time PCR, from which CSTA, DAP13, TAF12, RIS1, CDKN3 and MAGOH were up-regulated, and KLHL11 and NCOA2 were down-regulated.
11489729	underexpression	Prostate Carcinoma	In every prostatic tissue specimen, the expression levels of TIF2 and RAC3 were very low.
10690532	overexpression	Ductal Breast Carcinoma In Situ	The expression levels of ER-alpha, TIF2, and CBP were significantly higher in the intraductal carcinomas than those in the normal mammary glands.

Summary
Symbol	NCOA2
Name	nuclear receptor coactivator 2
Aliases	TIF2; NCoA-2; KAT13C; bHLHe75; class E basic helix-loop-helix protein 75; glucocorticoid receptor-interactin ......
Location	8q13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

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Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.156	0.00171	6.9	37.9	55.2	Gain
BRCA	Breast invasive carcinoma	1075	0.249	1.28e-16	4.7	40.7	54.6	Gain
CESC	Cervical and endocervical cancers	292	0.068	0.247	7.5	60.3	32.2	Neutral
COAD	Colon adenocarcinoma	449	0.325	1.68e-12	2.9	43.2	53.9	Gain
ESCA	Esophageal carcinoma	183	0.336	3.43e-06	8.2	33.3	58.5	Gain
GBM	Glioblastoma multiforme	147	0.286	0.000455	10.9	78.2	10.9	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.074	0.0954	4.5	31.9	63.6	Gain
KIRC	Kidney renal clear cell carcinoma	525	0.072	0.1	13	74.5	12.6	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.088	0.137	3.5	88.2	8.3	Neutral
LAML	Acute Myeloid Leukemia	166	0.272	0.000398	0	88	12	Neutral
LGG	Brain Lower Grade Glioma	513	0.098	0.0263	2.7	87.3	9.9	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.053	0.312	5.2	39.3	55.5	Gain
LUAD	Lung adenocarcinoma	512	0.274	2.86e-10	9.2	39.6	51.2	Gain
LUSC	Lung squamous cell carcinoma	498	0.277	3.01e-10	11.4	34.5	54	Gain
OV	Ovarian serous cystadenocarcinoma	300	0.497	3.95e-20	13.3	30	56.7	Gain
PAAD	Pancreatic adenocarcinoma	177	0.247	0.000933	8.5	63.8	27.7	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.055	0.491	7.4	83.3	9.3	Neutral
PRAD	Prostate adenocarcinoma	491	0.106	0.0185	0.8	68.2	31	Neutral
READ	Rectum adenocarcinoma	164	0.373	8.83e-07	4.9	37.2	57.9	Gain
SARC	Sarcoma	255	0.267	1.54e-05	13.7	55.7	30.6	Neutral
SKCM	Skin Cutaneous Melanoma	367	0.221	1.91e-05	6	46	48	Gain
STAD	Stomach adenocarcinoma	413	0.319	3.31e-11	6.5	36.3	57.1	Gain
TGCT	Testicular Germ Cell Tumors	150	0.291	0.000296	2	16	82	Gain
THCA	Thyroid carcinoma	497	-0.003	0.952	0.8	97.8	1.4	Neutral
THYM	Thymoma	119	0.065	0.485	1.7	89.9	8.4	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.202	2.28e-06	2.6	64.8	32.6	Neutral

Summary
Symbol	NCOA2
Name	nuclear receptor coactivator 2
Aliases	TIF2; NCoA-2; KAT13C; bHLHe75; class E basic helix-loop-helix protein 75; glucocorticoid receptor-interactin ......
Location	8q13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

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Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.178	0.000239	17	408	0.031	0.484	NS/NA
BRCA	Breast invasive carcinoma	-0.234	3.64e-12	83	785	0	0.161	NS/NA
CESC	Cervical and endocervical cancers	-0.224	7.46e-05	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.169	0.00264	19	297	-0.014	1.47e-06	NS/NA
ESCA	Esophageal carcinoma	-0.317	7.54e-06	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.317	0.0103	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.207	1.26e-06	20	522	-0.001	0.58	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.163	0.00243	24	319	0.219	2.18e-09	Increased
KIRP	Kidney renal papillary cell carcinoma	-0.336	3.46e-09	23	275	0.061	7.39e-12	NS/NA
LAML	Acute Myeloid Leukemia	-0.187	0.0147	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.183	2.24e-05	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.173	0.000404	41	373	0.086	0.000215	NS/NA
LUAD	Lung adenocarcinoma	-0.265	4.68e-09	21	456	-0.091	3.15e-10	NS/NA
LUSC	Lung squamous cell carcinoma	-0.231	6.03e-06	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.733	0.0311	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.317	1.37e-05	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.24	0.000984	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.276	1.15e-10	35	498	0.04	3.24e-06	NS/NA
READ	Rectum adenocarcinoma	-0.406	3.03e-05	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.19	0.00195	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.196	1.83e-05	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.23	8.2e-06	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.524	0	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.131	0.00196	50	509	0.017	0.000692	NS/NA
THYM	Thymoma	-0.256	0.0046	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.093	0.0455	34	431	-0.001	0.00449	NS/NA

Summary
Symbol	NCOA2
Name	nuclear receptor coactivator 2
Aliases	TIF2; NCoA-2; KAT13C; bHLHe75; class E basic helix-loop-helix protein 75; glucocorticoid receptor-interactin ......
Location	8q13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA) [ TOP ]
There is no antibody staining data.

Summary
Symbol	NCOA2
Name	nuclear receptor coactivator 2
Aliases	TIF2; NCoA-2; KAT13C; bHLHe75; class E basic helix-loop-helix protein 75; glucocorticoid receptor-interactin ......
Location	8q13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.459	NS	24476821
BRCA	Breast invasive carcinoma	521	1.4e-05	Significant	23000897
COAD	Colon adenocarcinoma	149	0.214	NS	22810696
GBM	Glioblastoma multiforme	157	0.176	NS	26824661
HNSC	Head and Neck squamous cell carcinoma	279	1.31e-06	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.00943	Significant	26536169
LGG	Brain Lower Grade Glioma	513	2.59e-08	Significant	26824661
LUAD	Lung adenocarcinoma	230	0.093	NS	25079552
LUSC	Lung squamous cell carcinoma	178	0.0984	NS	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.113	NS	21720365
PRAD	Prostate adenocarcinoma	333	0.915	NS	26544944
READ	Rectum adenocarcinoma	67	0.0201	Significant	22810696
SKCM	Skin Cutaneous Melanoma	315	0.00419	Significant	26091043
STAD	Stomach adenocarcinoma	277	0.165	NS	25079317
THCA	Thyroid carcinoma	391	0.00223	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.444	NS	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	1.25	0.301	NS
BRCA	Breast invasive carcinoma	1079	1.944	0.00469	Shorter
CESC	Cervical and endocervical cancers	291	2.439	0.0261	Shorter
COAD	Colon adenocarcinoma	439	0.782	0.421	NS
ESCA	Esophageal carcinoma	184	0.746	0.359	NS
GBM	Glioblastoma multiforme	158	0.725	0.206	NS
HNSC	Head and Neck squamous cell carcinoma	518	0.679	0.0475	Longer
KIRC	Kidney renal clear cell carcinoma	531	0.381	1.33e-05	Longer
KIRP	Kidney renal papillary cell carcinoma	287	1.223	0.664	NS
LAML	Acute Myeloid Leukemia	149	1.27	0.445	NS
LGG	Brain Lower Grade Glioma	511	0.592	0.0414	Longer
LIHC	Liver hepatocellular carcinoma	365	0.912	0.7	NS
LUAD	Lung adenocarcinoma	502	1.191	0.417	NS
LUSC	Lung squamous cell carcinoma	494	1.126	0.534	NS
OV	Ovarian serous cystadenocarcinoma	303	1.244	0.297	NS
PAAD	Pancreatic adenocarcinoma	177	1.589	0.102	NS
PCPG	Pheochromocytoma and Paraganglioma	179	597804225.586	0.156	NS
PRAD	Prostate adenocarcinoma	497	0	0.617	NS
READ	Rectum adenocarcinoma	159	0.769	0.602	NS
SARC	Sarcoma	259	1.373	0.316	NS
SKCM	Skin Cutaneous Melanoma	459	1.11	0.6	NS
STAD	Stomach adenocarcinoma	388	0.96	0.859	NS
TGCT	Testicular Germ Cell Tumors	134	1.15	0.921	NS
THCA	Thyroid carcinoma	500	2.34	0.295	NS
THYM	Thymoma	119	1.433	0.693	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	1.216	0.517	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	0.02	0.692	NS
BRCA	Breast invasive carcinoma	1071	0.011	0.71	NS
CESC	Cervical and endocervical cancers	167	0.032	0.681	NS
COAD	Colon adenocarcinoma	445	0.042	0.375	NS
ESCA	Esophageal carcinoma	162	-0.009	0.908	NS
HNSC	Head and Neck squamous cell carcinoma	448	-0.092	0.052	NS
KIRC	Kidney renal clear cell carcinoma	531	-0.136	0.00174	Lower
KIRP	Kidney renal papillary cell carcinoma	260	0.088	0.157	NS
LIHC	Liver hepatocellular carcinoma	347	-0.036	0.508	NS
LUAD	Lung adenocarcinoma	507	0.007	0.873	NS
LUSC	Lung squamous cell carcinoma	497	-0.002	0.965	NS
OV	Ovarian serous cystadenocarcinoma	302	0.045	0.434	NS
PAAD	Pancreatic adenocarcinoma	176	0.038	0.616	NS
READ	Rectum adenocarcinoma	156	0.125	0.121	NS
SKCM	Skin Cutaneous Melanoma	410	-0.01	0.837	NS
STAD	Stomach adenocarcinoma	392	0.009	0.862	NS
TGCT	Testicular Germ Cell Tumors	81	-0.153	0.171	NS
THCA	Thyroid carcinoma	499	-0.018	0.684	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	-0.03	0.501	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	-0.106	0.08	NS
HNSC	Head and Neck squamous cell carcinoma	498	-0.047	0.295	NS
KIRC	Kidney renal clear cell carcinoma	525	-0.111	0.0108	Lower
LGG	Brain Lower Grade Glioma	514	-0.098	0.0267	Lower
LIHC	Liver hepatocellular carcinoma	366	-0.041	0.437	NS
OV	Ovarian serous cystadenocarcinoma	296	0.106	0.0687	NS
PAAD	Pancreatic adenocarcinoma	176	0.055	0.467	NS
STAD	Stomach adenocarcinoma	406	-0.023	0.643	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.072	0.0946	NS

Summary
Symbol	NCOA2
Name	nuclear receptor coactivator 2
Aliases	TIF2; NCoA-2; KAT13C; bHLHe75; class E basic helix-loop-helix protein 75; glucocorticoid receptor-interactin ......
Location	8q13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	NCOA2
Name	nuclear receptor coactivator 2
Aliases	TIF2; NCoA-2; KAT13C; bHLHe75; class E basic helix-loop-helix protein 75; glucocorticoid receptor-interactin ......
Location	8q13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database

[ TOP ]

DrugBank ID	Name	Type
DB01645	Genistein	Small Molecule Drug
DB02998	Methyltrienolone	Small Molecule Drug
DB06871	17-METHYL-17-ALPHA-DIHYDROEQUILENIN	Small Molecule Drug
DB06898	4-(2-amino-1-methyl-1H-imidazo[4,5-b]pyridin-6-yl)phenol	Small Molecule Drug
DB07080	N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE	Small Molecule Drug
DB07086	4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-8-METHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL	Small Molecule Drug
DB07087	4-[(1S,2S,5S,9R)-5-(HYDROXYMETHYL)-8,9-DIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL	Small Molecule Drug
DB07195	4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-6,8,9-TRIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL	Small Molecule Drug
DB07678	(9ALPHA,13BETA,17BETA)-2-[(1Z)-BUT-1-EN-1-YL]ESTRA-1,3,5(10)-TRIENE-3,17-DIOL	Small Molecule Drug
DB07707	(9BETA,11ALPHA,13ALPHA,14BETA,17ALPHA)-11-(METHOXYMETHYL)ESTRA-1(10),2,4-TRIENE-3,17-DIOL	Small Molecule Drug
DB07708	3-CHLORO-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OL	Small Molecule Drug
DB07712	3-ETHYL-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OL	Small Molecule Drug
DB07863	2-chloro-5-nitro-N-phenylbenzamide	Small Molecule Drug
DB07932	dimethyl (1R,4S)-5,6-bis(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylate	Small Molecule Drug
DB08047	4-[1-allyl-7-(trifluoromethyl)-1H-indazol-3-yl]benzene-1,3-diol	Small Molecule Drug
DB08048	4-(6-HYDROXY-1H-INDAZOL-3-YL)BENZENE-1,3-DIOL	Small Molecule Drug
DB08175	(2E,4E)-11-METHOXY-3,7,11-TRIMETHYLDODECA-2,4-DIENOIC ACID	Small Molecule Drug
DB08320	DIETHYL (1R,2S,3R,4S)-5,6-BIS(4-HYDROXYPHENYL)-7-OXABICYCLO[2.2.1]HEPT-5-ENE-2,3-DICARBOXYLATE	Small Molecule Drug
DB08398	2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE	Small Molecule Drug
DB08402	2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACID	Small Molecule Drug
DB08595	4-[(1S,2R,5S)-4,4,8-TRIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL	Small Molecule Drug
DB08601	tributylstannanyl	Small Molecule Drug
DB08773	RALOXIFENE CORE	Small Molecule Drug

Summary
Symbol	NCOA2
Name	nuclear receptor coactivator 2
Aliases	TIF2; NCoA-2; KAT13C; bHLHe75; class E basic helix-loop-helix protein 75; glucocorticoid receptor-interactin ......
Location	8q13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
27633981	Angiofibroma	partner	AHRR; ETV4	Fusion	The t(5;8;17)(p15;q13;q21) threeway chromosomal translocation targeted AHRR (on 5p15), NCOA2 (on 8q13), and ETV4 (on 17q21) generating the inframe fusions AHRRNCOA2 and NCOA2ETV4 aswellas an outofframe ETV4AHRR transcript.
26854485	Acute Myeloid Leukemia	downstream	INK4a; ARF	negative regulation	We describe here that, indeed, MOZ-TIF2 silences expression of the CDKN2A locus (p16(INK4a) and p19(ARF)), inhibits the triggering of senescence and enhances proliferation, providing conditions favorable to the development of leukemia.
26845637	Angiofibroma	partner	AHRR	Fusion	The AHRR-NCOA2 fusion gene was detected in eight cases, and NCOA2 gene rearrangement in nine cases.
26501226	Spindle Cell Rhabdomyosarcoma	partner	VGLL2	Fusion	Ten of the 11 congenital/infantile SRMS showed recurrent fusion genes: with novel VGLL2 rearrangements seen in 7 (63%), including VGLL2-CITED2 fusion in 4 and VGLL2-NCOA2 in 2 cases.
25823027	Colorectal Carcinoma	partner	LACTB2	Fusion	This chimeric LACTB2-NCOA2 transcript was detected in 6 out of 99 (6.1%) colorectal cancer (CRC) cases, where NCOA2 was significantly downregulated.
25336010	Mesenchymal Chondrosarcoma	partner	HEY1	Fusion	Recently, a tumor-specific HEY1-NCOA2 fusion gene was identified in MC.
24213582	Embryonal Rhabdomyosarcoma	partner	PAX3	Fusion	We analyzed a complex chromosomal translocation in a case of embryonal rhabdomyosarcoma (RMS) and showed that it generates the fusion gene PAX3 (paired box 3)-NCOA2 (nuclear receptor coactivator 2).
24124145	Mesenchymal Chondrosarcoma	partner	HEY1	Fusion	HEY1-NCOA2 fusion transcript was detected in all six cases of mesenchymal chondrosarcoma but in none of the meningeal HPC cases (0/11) that were evaluable with RT-PCR.
23252872	Mesenchymal Chondrosarcoma	partner	HEY1	Fusion	A tumor specific fusion gene, HEY1-NCOA2 fusion, was recently identified in this tumor.
22373549	Acute Lymphoblastic Leukemia	partner	ETV6	Fusion	ETV6-RUNX1 were observed in six cases (3.4%), ETV6-JAK2 in three cases (1.7%), ETV6-ABL1 in two cases (1.1%), and ETV6-ABL2, ETV6-NCOA2, ETV6-SYK, and PAX5-ETV6 each in one case (0.6%).
22337624	Angiofibroma	partner	AHRR	Fusion	RT-PCR revealed in-frame AHRR/NCOA2 and NCOA2/AHHR transcripts in all four cases.
22034177	Mesenchymal Chondrosarcoma	partner	HEY1	Fusion	RT-PCR or FISH evidence of this HEY1-NCOA2 fusion was present in all additional mesenchymal chondrosarcomas tested with a definitive histologic diagnosis and adequate material for analysis (n = 9) but was absent in 15 samples of other subtypes of chondrosarcomas.
18754862	Acute Myeloid Leukemia	partner	MOZ	Fusion	The protein MOZ (monocytic leukemia zinc finger protein) is a Myst (MOZ, Ybf2 (Sas3), Sas2, Tip60)-type histone acetyltranseferase (HAT) that generates fusion genes, such as MOZ-TIF2, MOZ-CBP and MOZ-p300, in acute myeloid leukemia (AML) by chromosomal translocation.
18281529	Childhood Leukemia	partner	ETV6	Fusion	We have identified a novel recurrent t(8;12)(q13;p13), which results in a fusion between the transcriptional repressor ETV6 (TEL) and the transcriptional coactivator NCOA2 (TIF2) in six cases of childhood leukemia expressing both T-lymphoid and myeloid antigens.
17805042	Childhood Acute Myeloid Leukemia	partner	MOZ	Fusion	To our knowledge, this is the eighth overall and the fourth childhood case of acute myeloid leukemia with inv(8) (p11q13) with MOZ-TIF2 fusion.
12676584	Acute Myeloid Leukemia	partner	MOZ	Fusion	The MOZ-TIF2 fusion is associated with acute myeloid leukemia (AML) with inv(8)(p11q13).
10459350	Acute Myeloid Leukemia	partner	MOZ	Fusion	We have recently cloned the inv(8)(p11q13) in a patient with acute myeloid leukemia (AML), and demonstrated a fusion between the MOZ and TIF2 genes at 8p11 and 8q13, respectively.