CR2Cancer

Summary
Symbol	NCOA3
Name	nuclear receptor coactivator 3
Aliases	ACTR; p/CIP; TRAM-1; CAGH16; TNRC16; KAT13B; SRC-3; SRC3; receptor-associated coactivator 3; thyroid hormone ......
Location	20q13.12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

[ TOP ]

Domain

PF07469 Domain of unknown function (DUF1518)
PF16279 Domain of unknown function (DUF4927)
PF08815 Nuclear receptor coactivator
PF00989 PAS fold
PF08832 Steroid receptor coactivator

Function

Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit.

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification write	Histone acetylation	#	#	9267036

> Gene Ontology [ TOP ]
Biological Process	GO:0006473 protein acetylation GO:0006475 internal protein amino acid acetylation GO:0008544 epidermis development GO:0009755 hormone-mediated signaling pathway GO:0009913 epidermal cell differentiation GO:0010469 regulation of receptor activity GO:0016570 histone modification GO:0016573 histone acetylation GO:0018205 peptidyl-lysine modification GO:0018393 internal peptidyl-lysine acetylation GO:0018394 peptidyl-lysine acetylation GO:0030216 keratinocyte differentiation GO:0030518 intracellular steroid hormone receptor signaling pathway GO:0030521 androgen receptor signaling pathway GO:0030522 intracellular receptor signaling pathway GO:0030856 regulation of epithelial cell differentiation GO:0030858 positive regulation of epithelial cell differentiation GO:0032355 response to estradiol GO:0035624 receptor transactivation GO:0043401 steroid hormone mediated signaling pathway GO:0043543 protein acylation GO:0043588 skin development GO:0045604 regulation of epidermal cell differentiation GO:0045606 positive regulation of epidermal cell differentiation GO:0045616 regulation of keratinocyte differentiation GO:0045618 positive regulation of keratinocyte differentiation GO:0045682 regulation of epidermis development GO:0045684 positive regulation of epidermis development GO:0048545 response to steroid hormone GO:0071383 cellular response to steroid hormone stimulus GO:0071392 cellular response to estradiol stimulus GO:0071396 cellular response to lipid GO:0071407 cellular response to organic cyclic compound GO:2000273 positive regulation of receptor activity
Molecular Function	GO:0003713 transcription coactivator activity GO:0004402 histone acetyltransferase activity GO:0008080 N-acetyltransferase activity GO:0008134 transcription factor binding GO:0016407 acetyltransferase activity GO:0016410 N-acyltransferase activity GO:0016746 transferase activity, transferring acyl groups GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GO:0016922 ligand-dependent nuclear receptor binding GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity GO:0034212 peptide N-acetyltransferase activity GO:0035257 nuclear hormone receptor binding GO:0035258 steroid hormone receptor binding GO:0046966 thyroid hormone receptor binding GO:0047485 protein N-terminus binding GO:0050681 androgen receptor binding GO:0051427 hormone receptor binding GO:0061733 peptide-lysine-N-acetyltransferase activity
Cellular Component	GO:0000785 chromatin GO:0000790 nuclear chromatin GO:0044454 nuclear chromosome part

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04919 Thyroid hormone signaling pathway
Reactome	R-HSA-5619507: Activation of HOX genes during differentiation R-HSA-5617472: Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-1266738: Developmental Biology R-HSA-535734: Fatty acid, triacylglycerol, and ketone body metabolism R-HSA-5683057: MAPK family signaling cascades R-HSA-5687128: MAPK6/MAPK4 signaling R-HSA-1430728: Metabolism R-HSA-556833: Metabolism of lipids and lipoproteins R-HSA-1989781: PPARA activates gene expression R-HSA-400206: Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) R-HSA-162582: Signal Transduction R-HSA-381340: Transcriptional regulation of white adipocyte differentiation

> KEGG and Reactome Pathway

[ TOP ]

KEGG

hsa04919 Thyroid hormone signaling pathway

Reactome

R-HSA-5619507: Activation of HOX genes during differentiation
R-HSA-5617472: Activation of anterior HOX genes in hindbrain development during early embryogenesis
R-HSA-1266738: Developmental Biology
R-HSA-535734: Fatty acid, triacylglycerol, and ketone body metabolism
R-HSA-5683057: MAPK family signaling cascades
R-HSA-5687128: MAPK6/MAPK4 signaling
R-HSA-1430728: Metabolism
R-HSA-556833: Metabolism of lipids and lipoproteins
R-HSA-1989781: PPARA activates gene expression
R-HSA-400206: Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
R-HSA-162582: Signal Transduction
R-HSA-381340: Transcriptional regulation of white adipocyte differentiation

Summary
Symbol	NCOA3
Name	nuclear receptor coactivator 3
Aliases	ACTR; p/CIP; TRAM-1; CAGH16; TNRC16; KAT13B; SRC-3; SRC3; receptor-associated coactivator 3; thyroid hormone ......
Location	20q13.12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM4099090	c.46C>T	p.R16*	Substitution - Nonsense	Stomach
COSM1027546	c.3786G>A	p.Q1262Q	Substitution - coding silent	Central_nervous_system
COSM4099104	c.3953G>A	p.G1318E	Substitution - Missense	Stomach
COSM4896783	c.1607C>T	p.S536F	Substitution - Missense	Skin
COSM4099101	c.2883G>A	p.L961L	Substitution - coding silent	Stomach
COSM3371707	c.1073A>G	p.N358S	Substitution - Missense	Thyroid
COSM5718813	c.217A>G	p.K73E	Substitution - Missense	Skin
COSM3731923	c.3947-4T>C	p.?	Unknown	Stomach
COSM1565740	c.3765G>A	p.Q1255Q	Substitution - coding silent	Large_intestine
COSM1307487	c.3840C>T	p.F1280F	Substitution - coding silent	Urinary_tract
COSM1412260	c.4140G>A	p.Q1380Q	Substitution - coding silent	Large_intestine
COSM1027544	c.3568G>T	p.A1190S	Substitution - Missense	Endometrium
COSM3405165	c.3152G>T	p.R1051I	Substitution - Missense	Central_nervous_system
COSM4433083	c.4045C>T	p.Q1349*	Substitution - Nonsense	Oesophagus
COSM4925397	c.3877G>T	p.D1293Y	Substitution - Missense	Liver
COSM4649644	c.2379A>G	p.G793G	Substitution - coding silent	Large_intestine
COSM3547376	c.1459C>T	p.R487C	Substitution - Missense	Skin
COSM262330	c.625G>A	p.E209K	Substitution - Missense	Large_intestine
COSM1565740	c.3765G>A	p.Q1255Q	Substitution - coding silent	Large_intestine
COSM5446396	c.3789_3791delGCA	p.Q1276delQ	Deletion - In frame	Thyroid
COSM3423701	c.4083A>C	p.E1361D	Substitution - Missense	Large_intestine
COSM5611760	c.1197C>T	p.G399G	Substitution - coding silent	Adrenal_gland
COSM4134608	c.3563G>A	p.R1188Q	Substitution - Missense	Large_intestine
COSM4423542	c.1942G>A	p.E648K	Substitution - Missense	Central_nervous_system
COSM419360	c.1931C>G	p.S644*	Substitution - Nonsense	Urinary_tract
COSM1286524	c.2517G>A	p.L839L	Substitution - coding silent	Autonomic_ganglia
COSM1565740	c.3765G>A	p.Q1255Q	Substitution - coding silent	Large_intestine
COSM1565741	c.1560C>A	p.S520R	Substitution - Missense	Large_intestine
COSM3547380	c.2748C>T	p.S916S	Substitution - coding silent	Skin
COSM1565740	c.3765G>A	p.Q1255Q	Substitution - coding silent	Skin
COSM1483713	c.3741_3749delGCAGCAGCA	p.Q1274_Q1276delQQQ	Deletion - In frame	Upper_aerodigestive_tract
COSM1483713	c.3741_3749delGCAGCAGCA	p.Q1274_Q1276delQQQ	Deletion - In frame	Upper_aerodigestive_tract
COSM1565740	c.3765G>A	p.Q1255Q	Substitution - coding silent	Skin
COSM5990554	c.3947-10delT	p.?	Unknown	Liver
COSM1162450	c.3313G>A	p.D1105N	Substitution - Missense	Pancreas
COSM1713610	c.1160T>C	p.I387T	Substitution - Missense	Skin
COSM3749716	c.3753G>A	p.Q1251Q	Substitution - coding silent	Biliary_tract
COSM1027546	c.3786G>A	p.Q1262Q	Substitution - coding silent	Kidney
COSM1027547	c.3801G>T	p.Q1267H	Substitution - Missense	Endometrium
COSM1190279	c.1778T>A	p.L593H	Substitution - Missense	Lung
COSM5623932	c.1248C>G	p.A416A	Substitution - coding silent	Oesophagus
COSM5418406	c.299T>C	p.V100A	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4186980	c.627A>T	p.E209D	Substitution - Missense	Kidney
COSM1216858	c.107G>A	p.R36Q	Substitution - Missense	Large_intestine
COSM3547385	c.3854A>C	p.N1285T	Substitution - Missense	Skin
COSM4099094	c.1212G>A	p.S404S	Substitution - coding silent	Stomach
COSM3749716	c.3753G>A	p.Q1251Q	Substitution - coding silent	Large_intestine
COSM3911517	c.1190C>T	p.S397L	Substitution - Missense	Skin
COSM245966	c.3756G>A	p.Q1252Q	Substitution - coding silent	Oesophagus
COSM5718813	c.217A>G	p.K73E	Substitution - Missense	Skin
COSM3547383	c.3486C>T	p.P1162P	Substitution - coding silent	Skin
COSM1027546	c.3786G>A	p.Q1262Q	Substitution - coding silent	Pancreas
COSM1681738	c.955T>G	p.Y319D	Substitution - Missense	Ovary
COSM443955	c.4010C>T	p.S1337L	Substitution - Missense	Skin
COSM5713455	c.258delA	p.T88fs*26	Deletion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM4099102	c.2891G>A	p.R964Q	Substitution - Missense	Stomach
COSM3357258	c.841G>T	p.D281Y	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5631506	c.1760C>T	p.S587L	Substitution - Missense	Oesophagus
COSM1216859	c.580A>C	p.T194P	Substitution - Missense	Large_intestine
COSM3547378	c.2075G>A	p.G692E	Substitution - Missense	Skin
COSM1483709	c.526T>C	p.S176P	Substitution - Missense	Breast
COSM5392265	c.2656G>A	p.G886S	Substitution - Missense	Skin
COSM1412258	c.3789G>A	p.Q1263Q	Substitution - coding silent	Large_intestine
COSM3785413	c.2255C>T	p.S752F	Substitution - Missense	Pancreas
COSM3991754	c.357G>A	p.Q119Q	Substitution - coding silent	Kidney
COSM5001754	c.3535C>A	p.Q1179K	Substitution - Missense	Pancreas
COSM4099099	c.2467C>T	p.H823Y	Substitution - Missense	Stomach
COSM4986902	c.652C>T	p.R218C	Substitution - Missense	Soft_tissue
COSM478246	c.3565C>G	p.Q1189E	Substitution - Missense	Kidney
COSM22033	c.1496C>T	p.P499L	Substitution - Missense	Lung
COSM1565740	c.3765G>A	p.Q1255Q	Substitution - coding silent	Large_intestine
COSM4705950	c.3078T>C	p.N1026N	Substitution - coding silent	Large_intestine
COSM1412256	c.3759G>A	p.Q1253Q	Substitution - coding silent	Prostate
COSM1027546	c.3786G>A	p.Q1262Q	Substitution - coding silent	Prostate
COSM4426271	c.2375A>T	p.E792V	Substitution - Missense	Oesophagus
COSM4705947	c.593G>A	p.R198H	Substitution - Missense	Large_intestine
COSM3991753	c.257G>T	p.G86V	Substitution - Missense	Kidney
COSM5829044	c.3787_3792delCAGCAA	p.Q1275_Q1276delQQ	Deletion - In frame	Large_intestine
COSM5718813	c.217A>G	p.K73E	Substitution - Missense	Skin
COSM1615692	c.996A>G	p.V332V	Substitution - coding silent	Liver
COSM4915896	c.3390A>G	p.G1130G	Substitution - coding silent	Liver
COSM1483713	c.3741_3749delGCAGCAGCA	p.Q1274_Q1276delQQQ	Deletion - In frame	Large_intestine
COSM5414706	c.1473G>T	p.K491N	Substitution - Missense	Breast
COSM1307486	c.493G>A	p.D165N	Substitution - Missense	Urinary_tract
COSM1307487	c.3840C>T	p.F1280F	Substitution - coding silent	Urinary_tract
COSM1326697	c.2154C>T	p.D718D	Substitution - coding silent	Stomach
COSM1027536	c.993A>G	p.P331P	Substitution - coding silent	Endometrium
COSM3911518	c.2545C>T	p.R849C	Substitution - Missense	Skin
COSM5366098	c.2427T>C	p.S809S	Substitution - coding silent	Large_intestine
COSM1158215	c.981T>C	p.H327H	Substitution - coding silent	Pancreas
COSM4754291	c.667A>T	p.T223S	Substitution - Missense	Stomach
COSM3841216	c.3410C>G	p.S1137C	Substitution - Missense	Breast
COSM294607	c.977G>A	p.G326D	Substitution - Missense	Large_intestine
COSM5588419	c.1587C>A	p.I529I	Substitution - coding silent	Skin
COSM1027541	c.2561G>A	p.R854Q	Substitution - Missense	Endometrium
COSM3547375	c.1417C>T	p.L473F	Substitution - Missense	Skin
COSM1027546	c.3786G>A	p.Q1262Q	Substitution - coding silent	Oesophagus
COSM1258840	c.2759G>A	p.W920*	Substitution - Nonsense	Oesophagus
COSM5824713	c.2123A>C	p.K708T	Substitution - Missense	Pancreas
COSM3972580	c.2525C>G	p.S842*	Substitution - Nonsense	Central_nervous_system
COSM1027546	c.3786G>A	p.Q1262Q	Substitution - coding silent	Large_intestine
COSM3963631	c.3002C>A	p.A1001E	Substitution - Missense	Lung
COSM3363283	c.2101A>C	p.I701L	Substitution - Missense	Kidney
COSM443953	c.3760_3762delCAA	p.Q1254delQ	Deletion - In frame	Haematopoietic_and_lymphoid_tissue
COSM4581857	c.3882G>A	p.G1294G	Substitution - coding silent	Bone
COSM1681739	c.3148G>A	p.E1050K	Substitution - Missense	Large_intestine
COSM1565740	c.3765G>A	p.Q1255Q	Substitution - coding silent	Skin
COSM1565740	c.3765G>A	p.Q1255Q	Substitution - coding silent	Large_intestine
COSM4164744	c.4025C>T	p.P1342L	Substitution - Missense	Kidney
COSM5581821	c.863C>T	p.S288F	Substitution - Missense	Skin
COSM75576	c.1076A>T	p.D359V	Substitution - Missense	Ovary
COSM6017923	c.2348C>T	p.P783L	Substitution - Missense	Skin
COSM3547386	c.3928C>T	p.P1310S	Substitution - Missense	Skin
COSM5990554	c.3947-10delT	p.?	Unknown	Liver
COSM1412259	c.3792A>G	p.Q1264Q	Substitution - coding silent	Kidney
COSM1713611	c.1655C>T	p.P552L	Substitution - Missense	Skin
COSM5892443	c.158C>T	p.S53F	Substitution - Missense	Skin
COSM5520764	c.1403A>T	p.H468L	Substitution - Missense	Biliary_tract
COSM478243	c.256+2T>C	p.?	Unknown	Kidney
COSM1178116	c.3938C>A	p.P1313Q	Substitution - Missense	Prostate
COSM5576859	c.830T>C	p.V277A	Substitution - Missense	Skin
COSM1412246	c.210G>A	p.A70A	Substitution - coding silent	Large_intestine
COSM298921	c.2983G>A	p.A995T	Substitution - Missense	Liver
COSM1027546	c.3786G>A	p.Q1262Q	Substitution - coding silent	Large_intestine
COSM1027545	c.3771G>A	p.Q1257Q	Substitution - coding silent	Endometrium
COSM3673129	c.3715C>A	p.R1239R	Substitution - coding silent	Prostate
COSM5365902	c.3333T>C	p.Y1111Y	Substitution - coding silent	Large_intestine
COSM1307485	c.487G>A	p.E163K	Substitution - Missense	Urinary_tract
COSM443954	c.3762A>G	p.Q1254Q	Substitution - coding silent	Large_intestine
COSM1412259	c.3792A>G	p.Q1264Q	Substitution - coding silent	Kidney
COSM3547377	c.1968C>T	p.P656P	Substitution - coding silent	Skin
COSM4771539	c.3762_3763insCAGCAG	p.Q1276_T1277insQQ	Insertion - In frame	Haematopoietic_and_lymphoid_tissue
COSM342961	c.1813G>T	p.G605W	Substitution - Missense	Lung
COSM4136945	c.3651+6G>C	p.?	Unknown	Ovary
COSM5611668	c.865A>T	p.M289L	Substitution - Missense	Adrenal_gland
COSM1027541	c.2561G>A	p.R854Q	Substitution - Missense	Large_intestine
COSM22005	c.2673G>A	p.M891I	Substitution - Missense	Skin
COSM1483713	c.3741_3749delGCAGCAGCA	p.Q1274_Q1276delQQQ	Deletion - In frame	Large_intestine
COSM4803715	c.1505-2A>G	p.?	Unknown	Liver
COSM4444025	c.2047C>T	p.R683W	Substitution - Missense	Large_intestine
COSM3423700	c.3637C>T	p.Q1213*	Substitution - Nonsense	Skin
COSM1027546	c.3786G>A	p.Q1262Q	Substitution - coding silent	Large_intestine
COSM1318831	c.1385delA	p.N462fs*2	Deletion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM6017924	c.3992C>T	p.P1331L	Substitution - Missense	Skin
COSM1565740	c.3765G>A	p.Q1255Q	Substitution - coding silent	Skin
COSM4451862	c.1425A>C	p.P475P	Substitution - coding silent	Skin
COSM112130	c.3595_3596insCTG	p.A1200_G1201insA	Insertion - In frame	Ovary
COSM1565740	c.3765G>A	p.Q1255Q	Substitution - coding silent	Large_intestine
COSM1713612	c.2828G>A	p.G943E	Substitution - Missense	Skin
COSM5963343	c.1450C>T	p.P484S	Substitution - Missense	Breast
COSM371584	c.864C>T	p.S288S	Substitution - coding silent	Lung
COSM4581856	c.1186A>C	p.S396R	Substitution - Missense	Bone
COSM673895	c.1112+7A>T	p.?	Unknown	Endometrium
COSM4986902	c.652C>T	p.R218C	Substitution - Missense	Soft_tissue
COSM5707469	c.2560C>T	p.R854*	Substitution - Nonsense	Haematopoietic_and_lymphoid_tissue
COSM5016844	c.56A>G	p.K19R	Substitution - Missense	Kidney
COSM4099089	c.22T>G	p.L8V	Substitution - Missense	Stomach
COSM1483710	c.3047C>G	p.S1016C	Substitution - Missense	Breast
COSM3547373	c.1005C>T	p.F335F	Substitution - coding silent	Skin
COSM3423700	c.3637C>T	p.Q1213*	Substitution - Nonsense	Large_intestine
COSM245967	c.4213A>G	p.M1405V	Substitution - Missense	Prostate
COSM1713613	c.3881G>A	p.G1294E	Substitution - Missense	Skin
COSM724353	c.2768C>A	p.P923Q	Substitution - Missense	Lung
COSM3295059	c.3417G>A	p.M1139I	Substitution - Missense	Large_intestine
COSM4136945	c.3651+6G>C	p.?	Unknown	Ovary
COSM3707813	c.385A>G	p.N129D	Substitution - Missense	Liver
COSM1326696	c.3389_3413del25	p.Q1131fs*1	Deletion - Frameshift	Ovary
COSM5392264	c.2631C>T	p.P877P	Substitution - coding silent	Skin
COSM3295025	c.1354T>C	p.S452P	Substitution - Missense	Large_intestine
COSM245966	c.3756G>A	p.Q1252Q	Substitution - coding silent	Kidney
COSM1412255	c.3611C>T	p.A1204V	Substitution - Missense	Large_intestine
COSM4803715	c.1505-2A>G	p.?	Unknown	Liver
COSM5992086	c.3784_3792delCAGCAGCAA	p.Q1274_Q1276delQQQ	Deletion - In frame	Prostate
COSM4915070	c.1940A>G	p.K647R	Substitution - Missense	Liver
COSM4940732	c.3127A>G	p.N1043D	Substitution - Missense	Liver
COSM4987716	c.1758G>C	p.Q586H	Substitution - Missense	Soft_tissue
COSM22033	c.1496C>T	p.P499L	Substitution - Missense	Skin
COSM4425640	c.3727G>A	p.V1243M	Substitution - Missense	Oesophagus
COSM3707813	c.385A>G	p.N129D	Substitution - Missense	Liver
COSM4987716	c.1758G>C	p.Q586H	Substitution - Missense	Soft_tissue
COSM1483713	c.3741_3749delGCAGCAGCA	p.Q1274_Q1276delQQQ	Deletion - In frame	Upper_aerodigestive_tract
COSM1641366	c.2066T>C	p.L689P	Substitution - Missense	Stomach
COSM3749716	c.3753G>A	p.Q1251Q	Substitution - coding silent	Large_intestine
COSM3547382	c.3467G>A	p.R1156Q	Substitution - Missense	Skin
COSM4099093	c.1135A>G	p.N379D	Substitution - Missense	Stomach
COSM5718813	c.217A>G	p.K73E	Substitution - Missense	Skin
COSM4099105	c.4271G>A	p.C1424Y	Substitution - Missense	Stomach
COSM3749716	c.3753G>A	p.Q1251Q	Substitution - coding silent	Large_intestine
COSM4167886	c.2669G>C	p.R890T	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1483713	c.3741_3749delGCAGCAGCA	p.Q1274_Q1276delQQQ	Deletion - In frame	Stomach
COSM1615693	c.3212A>C	p.E1071A	Substitution - Missense	Liver
COSM225086	c.1453C>T	p.R485C	Substitution - Missense	Skin
COSM4099096	c.1883C>T	p.S628F	Substitution - Missense	Stomach
COSM3668465	c.923A>G	p.N308S	Substitution - Missense	Liver
COSM1641366	c.2066T>C	p.L689P	Substitution - Missense	Stomach
COSM1027546	c.3786G>A	p.Q1262Q	Substitution - coding silent	Prostate
COSM5653411	c.522A>C	p.P174P	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM5829043	c.3786_3787insCAA	p.Q1276_T1277insQ	Insertion - In frame	Large_intestine
COSM1483711	c.3178C>T	p.L1060F	Substitution - Missense	Breast
COSM443949	c.241C>A	p.Q81K	Substitution - Missense	Breast
COSM1027539	c.1373A>C	p.N458T	Substitution - Missense	Endometrium
COSM1565740	c.3765G>A	p.Q1255Q	Substitution - coding silent	Large_intestine
COSM4774820	c.3805_3806insCAG	p.Q1269>PE	Complex - insertion inframe	Stomach
COSM1195718	c.637G>A	p.A213T	Substitution - Missense	Lung
COSM1027540	c.1616C>T	p.S539F	Substitution - Missense	Endometrium
COSM4705949	c.636C>T	p.N212N	Substitution - coding silent	Large_intestine
COSM5732050	c.2890C>T	p.R964W	Substitution - Missense	Pancreas
COSM4430707	c.3188A>G	p.N1063S	Substitution - Missense	Oesophagus
COSM4917401	c.1439T>G	p.I480S	Substitution - Missense	Liver
COSM3707814	c.2137A>G	p.I713V	Substitution - Missense	Liver
COSM1615691	c.20A>G	p.N7S	Substitution - Missense	Liver
COSM5511165	c.3497delC	p.K1168fs*17	Deletion - Frameshift	Biliary_tract
COSM1027546	c.3786G>A	p.Q1262Q	Substitution - coding silent	Skin
COSM1027542	c.3357G>A	p.G1119G	Substitution - coding silent	Endometrium
COSM2156613	c.1776C>T	p.H592H	Substitution - coding silent	Central_nervous_system
COSM1483713	c.3741_3749delGCAGCAGCA	p.Q1274_Q1276delQQQ	Deletion - In frame	Large_intestine
COSM5495637	c.2916A>G	p.R972R	Substitution - coding silent	Biliary_tract
COSM1258838	c.3379C>T	p.H1127Y	Substitution - Missense	Oesophagus
COSM4896681	c.1905C>T	p.S635S	Substitution - coding silent	Skin
COSM1681739	c.3148G>A	p.E1050K	Substitution - Missense	Large_intestine
COSM5365841	c.2210T>G	p.L737R	Substitution - Missense	Large_intestine
COSM724352	c.4140G>T	p.Q1380H	Substitution - Missense	Lung
COSM4099097	c.2073T>C	p.N691N	Substitution - coding silent	Stomach
COSM3799622	c.2619C>G	p.I873M	Substitution - Missense	Oesophagus
COSM128730	c.3763_3765delCAG	p.Q1255delQ	Deletion - In frame	Liver
COSM3730727	c.2953+5G>A	p.?	Unknown	Stomach
COSM5990554	c.3947-10delT	p.?	Unknown	Liver
COSM4564742	c.1379_1380GG>AA	p.G460E	Substitution - Missense	Skin
COSM1027546	c.3786G>A	p.Q1262Q	Substitution - coding silent	Soft_tissue
COSM3738044	c.3488G>A	p.R1163Q	Substitution - Missense	Soft_tissue
COSM1483713	c.3741_3749delGCAGCAGCA	p.Q1274_Q1276delQQQ	Deletion - In frame	Upper_aerodigestive_tract
COSM4705948	c.615T>C	p.H205H	Substitution - coding silent	Large_intestine
COSM3841217	c.4024C>T	p.P1342S	Substitution - Missense	Breast
COSM245966	c.3756G>A	p.Q1252Q	Substitution - coding silent	Prostate
COSM443950	c.1234C>G	p.P412A	Substitution - Missense	Breast
COSM5990554	c.3947-10delT	p.?	Unknown	Liver
COSM245967	c.4213A>G	p.M1405V	Substitution - Missense	Oesophagus
COSM3749716	c.3753G>A	p.Q1251Q	Substitution - coding silent	Large_intestine
COSM443954	c.3762A>G	p.Q1254Q	Substitution - coding silent	Large_intestine
COSM4987716	c.1758G>C	p.Q586H	Substitution - Missense	Soft_tissue
COSM3547371	c.638C>T	p.A213V	Substitution - Missense	Skin
COSM3749716	c.3753G>A	p.Q1251Q	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM478244	c.774A>T	p.R258S	Substitution - Missense	Kidney
COSM3799621	c.274G>A	p.D92N	Substitution - Missense	Urinary_tract
COSM1258839	c.1401A>C	p.P467P	Substitution - coding silent	Oesophagus
COSM71797	c.1696G>T	p.D566Y	Substitution - Missense	Ovary
COSM5451578	c.1887T>C	p.S629S	Substitution - coding silent	Large_intestine
COSM478245	c.2808C>G	p.N936K	Substitution - Missense	Kidney
COSM22005	c.2673G>A	p.M891I	Substitution - Missense	Skin
COSM443954	c.3762A>G	p.Q1254Q	Substitution - coding silent	Large_intestine
COSM4188535	c.1281G>C	p.Q427H	Substitution - Missense	Kidney
COSM5392266	c.3512G>A	p.R1171K	Substitution - Missense	Skin
COSM1027543	c.3512G>T	p.R1171I	Substitution - Missense	Endometrium
COSM3799622	c.2619C>G	p.I873M	Substitution - Missense	Urinary_tract
COSM298921	c.2983G>A	p.A995T	Substitution - Missense	Large_intestine
COSM4099095	c.1480T>C	p.S494P	Substitution - Missense	Stomach
COSM4563134	c.95G>A	p.S32N	Substitution - Missense	Skin
COSM5414706	c.1473G>T	p.K491N	Substitution - Missense	Breast
COSM1326697	c.2154C>T	p.D718D	Substitution - coding silent	Stomach
COSM3547382	c.3467G>A	p.R1156Q	Substitution - Missense	Stomach
COSM724355	c.347T>G	p.L116R	Substitution - Missense	Lung
COSM3749716	c.3753G>A	p.Q1251Q	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM1412248	c.930G>A	p.G310G	Substitution - coding silent	Large_intestine
COSM4609747	c.916_917ins34	p.L307fs*2	Insertion - Frameshift	Adrenal_gland
COSM1193963	c.3632A>T	p.Q1211L	Substitution - Missense	Lung
COSM5365902	c.3333T>C	p.Y1111Y	Substitution - coding silent	Large_intestine
COSM1483713	c.3741_3749delGCAGCAGCA	p.Q1274_Q1276delQQQ	Deletion - In frame	Breast
COSM4099098	c.2321T>G	p.I774S	Substitution - Missense	Stomach
COSM724354	c.2410C>T	p.L804F	Substitution - Missense	Lung
COSM5829045	c.3805_3813delCAGCAACAG	p.Q1274_Q1276delQQQ	Deletion - In frame	Large_intestine
COSM3841215	c.2709T>G	p.G903G	Substitution - coding silent	Breast
COSM5930026	c.2863G>A	p.G955S	Substitution - Missense	Skin
COSM1190280	c.3889G>C	p.A1297P	Substitution - Missense	Lung
COSM4134608	c.3563G>A	p.R1188Q	Substitution - Missense	Thyroid
COSM443954	c.3762A>G	p.Q1254Q	Substitution - coding silent	Large_intestine
COSM162838	c.2178G>T	p.Q726H	Substitution - Missense	Breast
COSM4486963	c.3121C>T	p.P1041S	Substitution - Missense	Skin
COSM1236472	c.3100C>A	p.L1034M	Substitution - Missense	Autonomic_ganglia
COSM1615693	c.3212A>C	p.E1071A	Substitution - Missense	Liver
COSM75577	c.3593C>G	p.P1198R	Substitution - Missense	Ovary
COSM4099092	c.355C>T	p.Q119*	Substitution - Nonsense	Stomach
COSM121293	c.1711C>T	p.L571L	Substitution - coding silent	Upper_aerodigestive_tract
COSM288033	c.438A>G	p.Q146Q	Substitution - coding silent	Large_intestine
COSM1412249	c.1395delC	p.P467fs*15	Deletion - Frameshift	Large_intestine
COSM1027546	c.3786G>A	p.Q1262Q	Substitution - coding silent	Endometrium
COSM162837	c.2222T>C	p.L741P	Substitution - Missense	Breast
COSM1412245	c.122A>G	p.E41G	Substitution - Missense	Large_intestine
COSM1027537	c.1110G>C	p.Q370H	Substitution - Missense	Endometrium
COSM5343620	c.892C>T	p.R298*	Substitution - Nonsense	Large_intestine
COSM276281	c.3272A>C	p.K1091T	Substitution - Missense	Large_intestine
COSM1027538	c.1285A>C	p.S429R	Substitution - Missense	Endometrium
COSM3841214	c.2456C>G	p.S819*	Substitution - Nonsense	Breast
COSM1483713	c.3741_3749delGCAGCAGCA	p.Q1274_Q1276delQQQ	Deletion - In frame	Stomach
COSM1027546	c.3786G>A	p.Q1262Q	Substitution - coding silent	Urinary_tract
COSM4605243	c.3823C>T	p.Q1275*	Substitution - Nonsense	Upper_aerodigestive_tract
COSM1027548	c.4016G>T	p.R1339I	Substitution - Missense	Endometrium
COSM5594957	c.1211C>T	p.S404L	Substitution - Missense	Skin
COSM3686205	c.3740_3741insGCA	p.Q1276_T1277insQ	Insertion - In frame	Large_intestine
COSM5990554	c.3947-10delT	p.?	Unknown	Liver
COSM1027549	c.4172G>A	p.S1391N	Substitution - Missense	Endometrium
COSM3547384	c.3647C>T	p.S1216F	Substitution - Missense	Skin
COSM3911518	c.2545C>T	p.R849C	Substitution - Missense	Oesophagus
COSM1027546	c.3786G>A	p.Q1262Q	Substitution - coding silent	Kidney
COSM245966	c.3756G>A	p.Q1252Q	Substitution - coding silent	Prostate
COSM4494081	c.4269C>T	p.Y1423Y	Substitution - coding silent	Skin
COSM4596262	c.1462G>A	p.G488R	Substitution - Missense	Upper_aerodigestive_tract
COSM1326697	c.2154C>T	p.D718D	Substitution - coding silent	Ovary
COSM4099091	c.295G>A	p.D99N	Substitution - Missense	Stomach
COSM4910051	c.2795C>G	p.P932R	Substitution - Missense	Liver
COSM5774365	c.532+3A>C	p.?	Unknown	Breast
COSM4484953	c.2876C>T	p.P959L	Substitution - Missense	Skin
COSM1615691	c.20A>G	p.N7S	Substitution - Missense	Liver
COSM4826294	c.2012C>G	p.S671C	Substitution - Missense	Cervix
COSM3547374	c.1078C>G	p.R360G	Substitution - Missense	Skin
COSM3707814	c.2137A>G	p.I713V	Substitution - Missense	Liver
COSM3749716	c.3753G>A	p.Q1251Q	Substitution - coding silent	Large_intestine
COSM4981673	c.3655G>A	p.G1219S	Substitution - Missense	Oesophagus
COSM5719121	c.1750A>T	p.M584L	Substitution - Missense	Skin
COSM5858040	c.3445C>T	p.P1149S	Substitution - Missense	Oesophagus
COSM3547379	c.2743C>T	p.P915S	Substitution - Missense	Skin
COSM4987716	c.1758G>C	p.Q586H	Substitution - Missense	Soft_tissue
COSM245966	c.3756G>A	p.Q1252Q	Substitution - coding silent	Prostate
COSM393983	c.52C>T	p.R18C	Substitution - Missense	Lung
COSM4099102	c.2891G>A	p.R964Q	Substitution - Missense	Large_intestine
COSM4099103	c.3509T>A	p.L1170H	Substitution - Missense	Stomach
COSM2156613	c.1776C>T	p.H592H	Substitution - coding silent	Central_nervous_system
COSM1483713	c.3741_3749delGCAGCAGCA	p.Q1274_Q1276delQQQ	Deletion - In frame	Soft_tissue
COSM3547381	c.3269C>T	p.P1090L	Substitution - Missense	Skin
COSM3547370	c.592C>T	p.R198C	Substitution - Missense	Skin
COSM4465549	c.1359C>T	p.S453S	Substitution - coding silent	Skin
COSM1158215	c.981T>C	p.H327H	Substitution - coding silent	Pancreas
COSM3547372	c.691C>T	p.Q231*	Substitution - Nonsense	Skin
COSM22033	c.1496C>T	p.P499L	Substitution - Missense	Lung
COSM443952	c.1643T>G	p.L548W	Substitution - Missense	Breast
COSM1615692	c.996A>G	p.V332V	Substitution - coding silent	Liver
COSM5806973	c.3921A>G	p.Q1307Q	Substitution - coding silent	Liver
COSM4099100	c.2550T>A	p.P850P	Substitution - coding silent	Stomach
COSM128730	c.3763_3765delCAG	p.Q1255delQ	Deletion - In frame	Upper_aerodigestive_tract
COSM3693552	c.1238G>A	p.S413N	Substitution - Missense	Large_intestine
COSM3295049	c.2931G>A	p.Q977Q	Substitution - coding silent	Stomach
COSM5415627	c.2178G>A	p.Q726Q	Substitution - coding silent	Prostate
COSM245966	c.3756G>A	p.Q1252Q	Substitution - coding silent	Urinary_tract
COSM1565740	c.3765G>A	p.Q1255Q	Substitution - coding silent	Large_intestine
COSM3841213	c.423C>T	p.V141V	Substitution - coding silent	Breast
COSM4747149	c.3741_3746delGCAGCA	p.Q1275_Q1276delQQ	Deletion - In frame	Stomach
COSM1167591	c.212delT	p.L72fs*1	Deletion - Frameshift	Skin
COSM3707813	c.385A>G	p.N129D	Substitution - Missense	Liver
COSM5414706	c.1473G>T	p.K491N	Substitution - Missense	Breast

> Text Mining based Variations [ TOP ]
There is no record for NCOA3.

Summary
Symbol	NCOA3
Name	nuclear receptor coactivator 3
Aliases	ACTR; p/CIP; TRAM-1; CAGH16; TNRC16; KAT13B; SRC-3; SRC3; receptor-associated coactivator 3; thyroid hormone ......
Location	20q13.12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

[ TOP ]

Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
Q9Y6Q9	214	S	Phosphoserine	-	No	None detected
Q9Y6Q9	551	S	Phosphoserine	-	No	None detected
Q9Y6Q9	569	S	Phosphoserine	-	No	None detected
Q9Y6Q9	601	S	Phosphoserine	CK1	No	None detected
Q9Y6Q9	616	K	N6-acetyllysine	CREBBP	No	None detected
Q9Y6Q9	619	K	N6-acetyllysine	CREBBP	No	None detected
Q9Y6Q9	620	K	N6-acetyllysine	CREBBP	Yes	p.K620fs (cancer: STAD)
Q9Y6Q9	687	K	N6-acetyllysine	-	No	None detected
Q9Y6Q9	694	S	Phosphoserine	-	No	None detected
Q9Y6Q9	728	S	Phosphoserine	-	No	None detected
Q9Y6Q9	857	S	Phosphoserine	-	No	None detected
Q9Y6Q9	860	S	Phosphoserine	-	No	None detected
Q9Y6Q9	867	S	Phosphoserine	-	Yes	p.S867G (cancer: PRAD)
Q9Y6Q9	1033	S	Phosphoserine	-	No	None detected
Q9Y6Q9	1171	R	Asymmetric dimethylarginine	-	Yes	p.R1171I (cancer: UCEC)
Q9Y6Q9	1177	R	Asymmetric dimethylarginine	-	No	None detected
Q9Y6Q9	1188	R	Asymmetric dimethylarginine	-	No	None detected
Q9Y6Q9	1330	S	Phosphoserine	-	No	None detected

Summary
Symbol	NCOA3
Name	nuclear receptor coactivator 3
Aliases	ACTR; p/CIP; TRAM-1; CAGH16; TNRC16; KAT13B; SRC-3; SRC3; receptor-associated coactivator 3; thyroid hormone ......
Location	20q13.12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	5.995	6.485	0.288	0.167	NS
BRCA	Breast invasive carcinoma	112	1100	6.202	6.285	0.151	0.0391	NS
CESC	Cervical and endocervical cancers	3	306	5.684	6.167	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	5.695	5.762	0.011	0.92	NS
ESCA	Esophageal carcinoma	11	185	6.665	7.022	0.349	0.155	NS
GBM	Glioblastoma multiforme	5	166	4.733	5.069	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	6.049	6.351	0.33	0.00409	NS
KIRC	Kidney renal clear cell carcinoma	72	534	5.967	6.026	0.05	0.483	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	5.626	5.559	-0.034	0.776	NS
LAML	Acute Myeloid Leukemia	0	173	NA	7.368	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	5.415	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	4.657	4.74	0.184	0.0843	NS
LUAD	Lung adenocarcinoma	59	517	6.203	6.272	0.134	0.0966	NS
LUSC	Lung squamous cell carcinoma	51	501	6.186	6.485	0.366	0.000395	NS
OV	Ovarian serous cystadenocarcinoma	0	307	NA	6.35	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	5.801	5.948	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	4.935	4.552	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	5.81	5.673	-0.163	0.0592	NS
READ	Rectum adenocarcinoma	10	167	5.718	5.826	0.141	0.59	NS
SARC	Sarcoma	2	263	4.968	5.534	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	6.34	5.676	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	6.337	6.623	0.306	0.0089	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	6.059	NA	NA	NA
THCA	Thyroid carcinoma	59	509	5.812	5.81	-0.105	0.0835	NS
THYM	Thymoma	2	120	6.21	5.741	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	5.743	5.591	-0.137	0.303	NS

> Cancer Cell Line Encyclopedia (CCLE)

[ TOP ]

Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	6.9
Autonomic ganglia	CHP212	7.1
Autonomic ganglia	IMR32	6.7
Autonomic ganglia	KELLY	7.3
Autonomic ganglia	KPNRTBM1	7.5
Autonomic ganglia	KPNSI9S	7.4
Autonomic ganglia	KPNYN	7
Autonomic ganglia	MHHNB11	7.4
Autonomic ganglia	NB1	7.7
Autonomic ganglia	NH6	7
Autonomic ganglia	SHSY5Y	7.2
Autonomic ganglia	SIMA	8.1
Autonomic ganglia	SKNAS	7.1
Autonomic ganglia	SKNBE2	7.1
Autonomic ganglia	SKNDZ	7.4
Autonomic ganglia	SKNFI	7.4
Autonomic ganglia	SKNSH	6.8
Biliary tract	HUCCT1	7.8
Biliary tract	HUH28	7.8
Biliary tract	SNU1079	7.7
Biliary tract	SNU1196	8.2
Biliary tract	SNU245	7.5
Biliary tract	SNU308	8.9
Biliary tract	SNU478	8
Bone	143B	7.4
Bone	A673	7.4
Bone	CADOES1	6.8
Bone	CAL78	7.2
Bone	G292CLONEA141B1	8
Bone	HOS	7.8
Bone	HS706T	7.4
Bone	HS737T	8.5
Bone	HS819T	8.4
Bone	HS821T	8.6
Bone	HS822T	8.1
Bone	HS863T	9
Bone	HS870T	7.5
Bone	HS888T	7.7
Bone	MG63	7.5
Bone	MHHES1	8.4
Bone	OUMS27	8.4
Bone	RDES	7.8
Bone	SJSA1	7.3
Bone	SKES1	7
Bone	SKNMC	7.8
Bone	SW1353	7.7
Bone	T173	8.3
Bone	TC71	7
Bone	U2OS	7.5
Breast	AU565	9.5
Breast	BT20	9.8
Breast	BT474	11.2
Breast	BT483	9.8
Breast	BT549	7.7
Breast	CAL120	8.6
Breast	CAL148	8.2
Breast	CAL51	9.3
Breast	CAL851	7.9
Breast	CAMA1	8.7
Breast	DU4475	6.9
Breast	EFM192A	9.6
Breast	EFM19	9.1
Breast	EVSAT	7.6
Breast	HCC1143	8.9
Breast	HCC1187	7.6
Breast	HCC1395	8.6
Breast	HCC1419	10
Breast	HCC1428	8.1
Breast	HCC1500	8.5
Breast	HCC1569	8.6
Breast	HCC1599	7.6
Breast	HCC1806	9.3
Breast	HCC1937	9
Breast	HCC1954	9.2
Breast	HCC202	8.1
Breast	HCC2157	8.6
Breast	HCC2218	8.5
Breast	HCC38	7.8
Breast	HCC70	8.1
Breast	HDQP1	8.5
Breast	HMC18	8.3
Breast	HS274T	9.2
Breast	HS281T	8.4
Breast	HS343T	8.2
Breast	HS578T	8
Breast	HS606T	7.6
Breast	HS739T	7.6
Breast	HS742T	8.1
Breast	JIMT1	10.1
Breast	KPL1	11.7
Breast	MCF7	11.7
Breast	MDAMB134VI	7.3
Breast	MDAMB157	7.4
Breast	MDAMB175VII	9.1
Breast	MDAMB231	7.4
Breast	MDAMB361	8.4
Breast	MDAMB415	8.7
Breast	MDAMB436	7
Breast	MDAMB453	8.7
Breast	MDAMB468	8.1
Breast	SKBR3	9.6
Breast	T47D	8.6
Breast	UACC812	8.1
Breast	UACC893	8.7
Breast	YMB1	8.7
Breast	ZR751	8.6
Breast	ZR7530	9.5
Central nervous system	1321N1	7.9
Central nervous system	42MGBA	8.6
Central nervous system	8MGBA	7.7
Central nervous system	A172	7.4
Central nervous system	AM38	6.6
Central nervous system	BECKER	7.9
Central nervous system	CAS1	7.8
Central nervous system	CCFSTTG1	7
Central nervous system	D283MED	10.3
Central nervous system	D341MED	7.4
Central nervous system	DAOY	7
Central nervous system	DBTRG05MG	7.2
Central nervous system	DKMG	8.2
Central nervous system	GAMG	7.8
Central nervous system	GB1	7
Central nervous system	GI1	7.5
Central nervous system	GMS10	8.4
Central nervous system	GOS3	6.7
Central nervous system	H4	7.2
Central nervous system	HS683	7.4
Central nervous system	KALS1	7.4
Central nervous system	KG1C	8.2
Central nervous system	KNS42	6.3
Central nervous system	KNS60	7.9
Central nervous system	KNS81	6.7
Central nervous system	KS1	7.5
Central nervous system	LN18	7.5
Central nervous system	LN229	7.8
Central nervous system	M059K	7.7
Central nervous system	MOGGCCM	6.9
Central nervous system	MOGGUVW	7.3
Central nervous system	NMCG1	7
Central nervous system	ONS76	8.6
Central nervous system	SF126	8
Central nervous system	SF295	7
Central nervous system	SNB19	6.7
Central nervous system	SNU1105	7.3
Central nervous system	SNU201	7.3
Central nervous system	SNU466	7.6
Central nervous system	SNU489	8.5
Central nervous system	SNU626	6.3
Central nervous system	SNU738	9.9
Central nervous system	SW1088	7.8
Central nervous system	SW1783	7.3
Central nervous system	T98G	7.8
Central nervous system	TM31	7
Central nervous system	U118MG	7.9
Central nervous system	U138MG	8.1
Central nervous system	U251MG	6.3
Central nervous system	U87MG	7.6
Central nervous system	YH13	7.4
Central nervous system	YKG1	7.2
Endometrium	AN3CA	7.8
Endometrium	COLO684	7.3
Endometrium	EFE184	9
Endometrium	EN	7.6
Endometrium	ESS1	8
Endometrium	HEC108	8.1
Endometrium	HEC151	6.8
Endometrium	HEC1A	7.7
Endometrium	HEC1B	8.5
Endometrium	HEC251	8
Endometrium	HEC265	7.8
Endometrium	HEC50B	8.1
Endometrium	HEC59	8.7
Endometrium	HEC6	7.8
Endometrium	ISHIKAWAHERAKLIO02ER	7.9
Endometrium	JHUEM1	8.9
Endometrium	JHUEM2	7.7
Endometrium	JHUEM3	7.9
Endometrium	KLE	6.7
Endometrium	MFE280	7.2
Endometrium	MFE296	7.5
Endometrium	MFE319	7
Endometrium	RL952	9.6
Endometrium	SNGM	8.1
Endometrium	SNU1077	8.4
Endometrium	SNU685	7.9
Endometrium	TEN	9
Haematopoietic and lymphoid	697	8.3
Haematopoietic and lymphoid	A3KAW	7.7
Haematopoietic and lymphoid	A4FUK	9.1
Haematopoietic and lymphoid	ALLSIL	7.7
Haematopoietic and lymphoid	AML193	6.9
Haematopoietic and lymphoid	AMO1	10.2
Haematopoietic and lymphoid	BCP1	7.8
Haematopoietic and lymphoid	BDCM	9.5
Haematopoietic and lymphoid	BL41	9.3
Haematopoietic and lymphoid	BL70	9.1
Haematopoietic and lymphoid	BV173	8.6
Haematopoietic and lymphoid	CA46	9.3
Haematopoietic and lymphoid	CI1	10
Haematopoietic and lymphoid	CMK115	7.4
Haematopoietic and lymphoid	CMK86	6.9
Haematopoietic and lymphoid	CMK	7.6
Haematopoietic and lymphoid	CMLT1	8.8
Haematopoietic and lymphoid	COLO775	9.4
Haematopoietic and lymphoid	DAUDI	10.2
Haematopoietic and lymphoid	DB	10.2
Haematopoietic and lymphoid	DEL	8.3
Haematopoietic and lymphoid	DND41	8
Haematopoietic and lymphoid	DOHH2	10.7
Haematopoietic and lymphoid	EB1	9.8
Haematopoietic and lymphoid	EB2	9.6
Haematopoietic and lymphoid	EHEB	10.3
Haematopoietic and lymphoid	EJM	8.8
Haematopoietic and lymphoid	EM2	8.2
Haematopoietic and lymphoid	EOL1	8
Haematopoietic and lymphoid	F36P	8.3
Haematopoietic and lymphoid	GA10	9.1
Haematopoietic and lymphoid	GDM1	8
Haematopoietic and lymphoid	GRANTA519	9.4
Haematopoietic and lymphoid	HDLM2	8.4
Haematopoietic and lymphoid	HDMYZ	7.3
Haematopoietic and lymphoid	HEL9217	6.8
Haematopoietic and lymphoid	HEL	6.7
Haematopoietic and lymphoid	HH	8.4
Haematopoietic and lymphoid	HL60	7.4
Haematopoietic and lymphoid	HPBALL	8
Haematopoietic and lymphoid	HS604T	8.3
Haematopoietic and lymphoid	HS611T	10.1
Haematopoietic and lymphoid	HS616T	8.7
Haematopoietic and lymphoid	HS751T	8.4
Haematopoietic and lymphoid	HT	11.2
Haematopoietic and lymphoid	HTK	7.5
Haematopoietic and lymphoid	HUNS1	8.6
Haematopoietic and lymphoid	HUT102	9.5
Haematopoietic and lymphoid	HUT78	7.6
Haematopoietic and lymphoid	JEKO1	9.1
Haematopoietic and lymphoid	JK1	7.7
Haematopoietic and lymphoid	JM1	8.8
Haematopoietic and lymphoid	JURKAT	8.1
Haematopoietic and lymphoid	JURLMK1	8.6
Haematopoietic and lymphoid	JVM2	11.2
Haematopoietic and lymphoid	JVM3	10.5
Haematopoietic and lymphoid	K562	8.2
Haematopoietic and lymphoid	KARPAS299	7.7
Haematopoietic and lymphoid	KARPAS422	9.7
Haematopoietic and lymphoid	KARPAS620	8.8
Haematopoietic and lymphoid	KASUMI1	6.9
Haematopoietic and lymphoid	KASUMI2	8.7
Haematopoietic and lymphoid	KASUMI6	7.7
Haematopoietic and lymphoid	KCL22	7.5
Haematopoietic and lymphoid	KE37	7
Haematopoietic and lymphoid	KE97	8.9
Haematopoietic and lymphoid	KG1	7.9
Haematopoietic and lymphoid	KHM1B	9.2
Haematopoietic and lymphoid	KIJK	6.6
Haematopoietic and lymphoid	KMH2	7.8
Haematopoietic and lymphoid	KMM1	8.9
Haematopoietic and lymphoid	KMS11	8.4
Haematopoietic and lymphoid	KMS12BM	9.6
Haematopoietic and lymphoid	KMS18	9.4
Haematopoietic and lymphoid	KMS20	9.4
Haematopoietic and lymphoid	KMS21BM	9.2
Haematopoietic and lymphoid	KMS26	8.5
Haematopoietic and lymphoid	KMS27	8.8
Haematopoietic and lymphoid	KMS28BM	7.8
Haematopoietic and lymphoid	KMS34	8.1
Haematopoietic and lymphoid	KO52	8
Haematopoietic and lymphoid	KOPN8	9.3
Haematopoietic and lymphoid	KU812	7.4
Haematopoietic and lymphoid	KYO1	7.5
Haematopoietic and lymphoid	L1236	8.1
Haematopoietic and lymphoid	L363	8.8
Haematopoietic and lymphoid	L428	10
Haematopoietic and lymphoid	L540	7.3
Haematopoietic and lymphoid	LAMA84	8.8
Haematopoietic and lymphoid	LOUCY	7.9
Haematopoietic and lymphoid	LP1	9.2
Haematopoietic and lymphoid	M07E	8.7
Haematopoietic and lymphoid	MC116	9.4
Haematopoietic and lymphoid	ME1	7.9
Haematopoietic and lymphoid	MEC1	10.3
Haematopoietic and lymphoid	MEC2	10.4
Haematopoietic and lymphoid	MEG01	7.4
Haematopoietic and lymphoid	MHHCALL2	8.9
Haematopoietic and lymphoid	MHHCALL3	7.8
Haematopoietic and lymphoid	MHHCALL4	9.4
Haematopoietic and lymphoid	MINO	9.3
Haematopoietic and lymphoid	MJ	7.9
Haematopoietic and lymphoid	MM1S	8.9
Haematopoietic and lymphoid	MOLM13	7.6
Haematopoietic and lymphoid	MOLM16	7.8
Haematopoietic and lymphoid	MOLM6	6.7
Haematopoietic and lymphoid	MOLP2	9.9
Haematopoietic and lymphoid	MOLP8	9.4
Haematopoietic and lymphoid	MOLT13	8.1
Haematopoietic and lymphoid	MOLT16	8.2
Haematopoietic and lymphoid	MOLT4	7.5
Haematopoietic and lymphoid	MONOMAC1	7.3
Haematopoietic and lymphoid	MONOMAC6	7.7
Haematopoietic and lymphoid	MOTN1	8
Haematopoietic and lymphoid	MUTZ5	8.5
Haematopoietic and lymphoid	MV411	7.6
Haematopoietic and lymphoid	NALM19	7.7
Haematopoietic and lymphoid	NALM1	7.9
Haematopoietic and lymphoid	NALM6	8.3
Haematopoietic and lymphoid	NAMALWA	9.7
Haematopoietic and lymphoid	NB4	8.2
Haematopoietic and lymphoid	NCIH929	10.6
Haematopoietic and lymphoid	NCO2	8
Haematopoietic and lymphoid	NOMO1	9
Haematopoietic and lymphoid	NUDHL1	9.3
Haematopoietic and lymphoid	NUDUL1	10
Haematopoietic and lymphoid	OCIAML2	7.7
Haematopoietic and lymphoid	OCIAML3	7.7
Haematopoietic and lymphoid	OCIAML5	7.3
Haematopoietic and lymphoid	OCILY10	8.5
Haematopoietic and lymphoid	OCILY19	8
Haematopoietic and lymphoid	OCILY3	9.8
Haematopoietic and lymphoid	OCIM1	9.3
Haematopoietic and lymphoid	OPM2	8.9
Haematopoietic and lymphoid	P12ICHIKAWA	8.3
Haematopoietic and lymphoid	P31FUJ	7.3
Haematopoietic and lymphoid	P3HR1	9.9
Haematopoietic and lymphoid	PCM6	9.1
Haematopoietic and lymphoid	PEER	7.5
Haematopoietic and lymphoid	PF382	7.9
Haematopoietic and lymphoid	PFEIFFER	11.6
Haematopoietic and lymphoid	PL21	8
Haematopoietic and lymphoid	RAJI	9.3
Haematopoietic and lymphoid	RCHACV	8.1
Haematopoietic and lymphoid	REC1	9.6
Haematopoietic and lymphoid	REH	7.8
Haematopoietic and lymphoid	RI1	8.8
Haematopoietic and lymphoid	RL	9.6
Haematopoietic and lymphoid	RPMI8226	9.3
Haematopoietic and lymphoid	RPMI8402	9
Haematopoietic and lymphoid	RS411	7
Haematopoietic and lymphoid	SEM	7.6
Haematopoietic and lymphoid	SET2	7.7
Haematopoietic and lymphoid	SIGM5	8.3
Haematopoietic and lymphoid	SKM1	7.9
Haematopoietic and lymphoid	SKMM2	8.3
Haematopoietic and lymphoid	SR786	7.1
Haematopoietic and lymphoid	ST486	7.6
Haematopoietic and lymphoid	SUDHL10	9.8
Haematopoietic and lymphoid	SUDHL1	8
Haematopoietic and lymphoid	SUDHL4	9.9
Haematopoietic and lymphoid	SUDHL5	10.8
Haematopoietic and lymphoid	SUDHL6	11.4
Haematopoietic and lymphoid	SUDHL8	9.3
Haematopoietic and lymphoid	SUPB15	8.1
Haematopoietic and lymphoid	SUPHD1	10.6
Haematopoietic and lymphoid	SUPM2	7.1
Haematopoietic and lymphoid	SUPT11	7.1
Haematopoietic and lymphoid	SUPT1	7.1
Haematopoietic and lymphoid	TALL1	8.3
Haematopoietic and lymphoid	TF1	7.4
Haematopoietic and lymphoid	THP1	7.2
Haematopoietic and lymphoid	TO175T	8.2
Haematopoietic and lymphoid	TOLEDO	8.7
Haematopoietic and lymphoid	U266B1	10.2
Haematopoietic and lymphoid	U937	7.4
Haematopoietic and lymphoid	UT7	8.3
Haematopoietic and lymphoid	WSUDLCL2	10.9
Kidney	769P	6.9
Kidney	786O	7.3
Kidney	A498	8
Kidney	A704	6.5
Kidney	ACHN	6.5
Kidney	BFTC909	8.1
Kidney	CAKI1	7.8
Kidney	CAKI2	9.4
Kidney	CAL54	7.6
Kidney	KMRC1	8.3
Kidney	KMRC20	6.5
Kidney	KMRC2	7.5
Kidney	KMRC3	7.6
Kidney	OSRC2	8.7
Kidney	RCC10RGB	7.1
Kidney	SNU1272	7.4
Kidney	SNU349	6.3
Kidney	TUHR10TKB	6.9
Kidney	TUHR14TKB	6.8
Kidney	TUHR4TKB	7.3
Kidney	VMRCRCW	6.7
Kidney	VMRCRCZ	6.5
Large intestine	C2BBE1	8.7
Large intestine	CCK81	7.6
Large intestine	CL11	8
Large intestine	CL14	8
Large intestine	CL34	7.5
Large intestine	CL40	6.9
Large intestine	COLO205	8
Large intestine	COLO320	7.8
Large intestine	COLO678	8.4
Large intestine	CW2	6.8
Large intestine	DLD1	7.8
Large intestine	GP2D	8.2
Large intestine	HCC56	7.6
Large intestine	HCT116	7.3
Large intestine	HCT15	7.6
Large intestine	HS675T	8.1
Large intestine	HS698T	8.2
Large intestine	HT115	7.5
Large intestine	HT29	7.6
Large intestine	HT55	7.9
Large intestine	KM12	8.2
Large intestine	LOVO	6.8
Large intestine	LS1034	7.3
Large intestine	LS123	8.7
Large intestine	LS180	6.8
Large intestine	LS411N	7
Large intestine	LS513	7
Large intestine	MDST8	7
Large intestine	NCIH508	7.7
Large intestine	NCIH716	8.2
Large intestine	NCIH747	8.8
Large intestine	OUMS23	9.5
Large intestine	RCM1	8.1
Large intestine	RKO	7.4
Large intestine	SKCO1	7.7
Large intestine	SNU1040	7.5
Large intestine	SNU1197	8.1
Large intestine	SNU175	7.6
Large intestine	SNU283	7.5
Large intestine	SNU407	8
Large intestine	SNU503	9.2
Large intestine	SNU61	8.2
Large intestine	SNU81	7.9
Large intestine	SNUC1	8.7
Large intestine	SNUC2A	7.9
Large intestine	SNUC4	7.4
Large intestine	SNUC5	7.8
Large intestine	SW1116	7.8
Large intestine	SW1417	7.7
Large intestine	SW1463	7.7
Large intestine	SW403	7.8
Large intestine	SW480	7.5
Large intestine	SW48	6.8
Large intestine	SW620	7.5
Large intestine	SW837	8.5
Large intestine	SW948	8.2
Large intestine	T84	7.8
Liver	ALEXANDERCELLS	8.9
Liver	C3A	7.8
Liver	HEP3B217	7.5
Liver	HEPG2	9
Liver	HLE	8.9
Liver	HLF	8
Liver	HUH1	9.2
Liver	HUH6	9.2
Liver	HUH7	7.4
Liver	JHH1	9.2
Liver	JHH2	8
Liver	JHH4	7.6
Liver	JHH5	8.4
Liver	JHH6	8.3
Liver	JHH7	8.1
Liver	LI7	7.8
Liver	PLCPRF5	8.7
Liver	SKHEP1	7.2
Liver	SNU182	8.2
Liver	SNU387	7.7
Liver	SNU398	7.4
Liver	SNU423	7.8
Liver	SNU449	9.5
Liver	SNU475	8.4
Liver	SNU761	7.9
Liver	SNU878	7.6
Liver	SNU886	7
Lung	A549	9.8
Lung	ABC1	9.3
Lung	BEN	8.2
Lung	CAL12T	9
Lung	CALU1	7.2
Lung	CALU3	9.1
Lung	CALU6	7.1
Lung	CHAGOK1	9.1
Lung	COLO668	7.1
Lung	COLO699	7.1
Lung	CORL105	8
Lung	CORL23	8.1
Lung	CORL24	8.2
Lung	CORL279	7.6
Lung	CORL311	9.6
Lung	CORL47	6.6
Lung	CORL51	6.8
Lung	CORL88	7.3
Lung	CORL95	7.1
Lung	CPCN	7.7
Lung	DMS114	7.5
Lung	DMS153	8.5
Lung	DMS273	7
Lung	DMS454	6.8
Lung	DMS53	7
Lung	DMS79	5.9
Lung	DV90	7.2
Lung	EBC1	7.9
Lung	EPLC272H	7.9
Lung	HARA	7.7
Lung	HCC1171	8.7
Lung	HCC1195	7.9
Lung	HCC15	7.3
Lung	HCC2279	8.1
Lung	HCC2935	9.4
Lung	HCC33	7
Lung	HCC366	8.4
Lung	HCC4006	7.9
Lung	HCC44	6.4
Lung	HCC78	7.7
Lung	HCC827	7.9
Lung	HCC95	9.5
Lung	HLC1	8.4
Lung	HLFA	7.9
Lung	HS229T	7.2
Lung	HS618T	7.4
Lung	IALM	7.7
Lung	KNS62	8.6
Lung	LC1F	10.3
Lung	LC1SQSF	10.7
Lung	LCLC103H	8.2
Lung	LCLC97TM1	8.1
Lung	LK2	7.1
Lung	LOUNH91	7.9
Lung	LU65	6.8
Lung	LU99	7.4
Lung	LUDLU1	9
Lung	LXF289	7.4
Lung	MORCPR	8.8
Lung	NCIH1048	7.7
Lung	NCIH1092	8.2
Lung	NCIH1105	8
Lung	NCIH1155	7.1
Lung	NCIH1184	7.8
Lung	NCIH1299	7.7
Lung	NCIH1339	7.6
Lung	NCIH1341	8.5
Lung	NCIH1355	9.2
Lung	NCIH1373	7.3
Lung	NCIH1385	8.6
Lung	NCIH1395	6.7
Lung	NCIH1435	8
Lung	NCIH1436	7.8
Lung	NCIH1437	8.9
Lung	NCIH146	6.7
Lung	NCIH1563	8.6
Lung	NCIH1568	9.1
Lung	NCIH1573	10
Lung	NCIH1581	7.6
Lung	NCIH1618	8.4
Lung	NCIH1623	8.7
Lung	NCIH1648	9.4
Lung	NCIH1650	9.7
Lung	NCIH1651	7.2
Lung	NCIH1666	9.5
Lung	NCIH1693	7.2
Lung	NCIH1694	7.2
Lung	NCIH1703	7.7
Lung	NCIH1734	7.5
Lung	NCIH1755	7.8
Lung	NCIH1781	8.8
Lung	NCIH1792	7.9
Lung	NCIH1793	9
Lung	NCIH1836	8.2
Lung	NCIH1838	7
Lung	NCIH1869	8.2
Lung	NCIH1876	7.9
Lung	NCIH1915	7
Lung	NCIH1930	7.8
Lung	NCIH1944	8.7
Lung	NCIH1963	7.4
Lung	NCIH196	7.8
Lung	NCIH1975	8.4
Lung	NCIH2009	8.8
Lung	NCIH2023	9.7
Lung	NCIH2029	8.9
Lung	NCIH2030	8.8
Lung	NCIH2066	7.9
Lung	NCIH2081	7.3
Lung	NCIH2085	9.6
Lung	NCIH2087	7.3
Lung	NCIH209	7.9
Lung	NCIH2106	6.1
Lung	NCIH2110	8.6
Lung	NCIH211	8.6
Lung	NCIH2122	8.3
Lung	NCIH2126	9.5
Lung	NCIH2141	8.2
Lung	NCIH2170	8.4
Lung	NCIH2171	7.1
Lung	NCIH2172	9.6
Lung	NCIH2196	8.5
Lung	NCIH2227	7.5
Lung	NCIH2228	7
Lung	NCIH226	7.7
Lung	NCIH2286	8.4
Lung	NCIH2291	7.7
Lung	NCIH2342	10.4
Lung	NCIH2347	7.5
Lung	NCIH23	8.1
Lung	NCIH2405	8.7
Lung	NCIH2444	8.4
Lung	NCIH292	8.4
Lung	NCIH322	9.1
Lung	NCIH3255	9
Lung	NCIH358	8.6
Lung	NCIH441	8.4
Lung	NCIH446	7.2
Lung	NCIH460	7.8
Lung	NCIH510	7.1
Lung	NCIH520	6.7
Lung	NCIH522	7.8
Lung	NCIH524	6.8
Lung	NCIH526	8.8
Lung	NCIH596	9.4
Lung	NCIH647	6.9
Lung	NCIH650	7.8
Lung	NCIH661	7.7
Lung	NCIH69	6.2
Lung	NCIH727	7.7
Lung	NCIH810	6.8
Lung	NCIH82	8.7
Lung	NCIH838	9.3
Lung	NCIH841	7.6
Lung	NCIH854	8
Lung	NCIH889	6.9
Lung	PC14	8.1
Lung	RERFLCAD1	7.9
Lung	RERFLCAD2	8.5
Lung	RERFLCAI	7.4
Lung	RERFLCKJ	8.4
Lung	RERFLCMS	8
Lung	RERFLCSQ1	8.5
Lung	SBC5	7
Lung	SCLC21H	6.5
Lung	SHP77	7.2
Lung	SKLU1	8.2
Lung	SKMES1	6.6
Lung	SQ1	6.9
Lung	SW1271	7.3
Lung	SW1573	7.4
Lung	SW900	7.2
Lung	VMRCLCD	6.8
Lung	VMRCLCP	9.7
Oesophagus	COLO680N	8.5
Oesophagus	ECGI10	8.9
Oesophagus	KYSE140	7.1
Oesophagus	KYSE150	8.7
Oesophagus	KYSE180	7.8
Oesophagus	KYSE270	7.6
Oesophagus	KYSE30	9
Oesophagus	KYSE410	9.1
Oesophagus	KYSE450	7
Oesophagus	KYSE510	9
Oesophagus	KYSE520	9
Oesophagus	KYSE70	9.5
Oesophagus	OE19	8
Oesophagus	OE33	9.2
Oesophagus	TE10	8.7
Oesophagus	TE11	9.6
Oesophagus	TE14	8.7
Oesophagus	TE15	8.4
Oesophagus	TE1	8.4
Oesophagus	TE4	7.7
Oesophagus	TE5	8.8
Oesophagus	TE6	8.7
Oesophagus	TE8	9.8
Oesophagus	TE9	9.4
Oesophagus	TT	8.6
Ovary	59M	7.8
Ovary	A2780	7.4
Ovary	CAOV3	6.7
Ovary	CAOV4	8.2
Ovary	COLO704	7.3
Ovary	COV318	8.7
Ovary	COV362	8
Ovary	COV434	9.5
Ovary	COV504	8.8
Ovary	COV644	7.3
Ovary	EFO21	8.1
Ovary	EFO27	8.8
Ovary	ES2	6.7
Ovary	FUOV1	8
Ovary	HEYA8	7.3
Ovary	HS571T	8.9
Ovary	IGROV1	8.3
Ovary	JHOC5	9
Ovary	JHOM1	8
Ovary	JHOM2B	8.6
Ovary	JHOS2	7.9
Ovary	JHOS4	8.8
Ovary	KURAMOCHI	8.5
Ovary	MCAS	7
Ovary	NIHOVCAR3	8.3
Ovary	OAW28	7.7
Ovary	OAW42	8.7
Ovary	OC314	7.8
Ovary	OC316	7.5
Ovary	ONCODG1	8.5
Ovary	OV56	10
Ovary	OV7	7.9
Ovary	OV90	9.7
Ovary	OVCAR4	8.5
Ovary	OVCAR8	8.1
Ovary	OVISE	10.5
Ovary	OVK18	8.7
Ovary	OVKATE	7.4
Ovary	OVMANA	9.8
Ovary	OVSAHO	8.1
Ovary	OVTOKO	7.9
Ovary	RMGI	9.3
Ovary	RMUGS	9.2
Ovary	SKOV3	8.6
Ovary	SNU119	9
Ovary	SNU840	8.8
Ovary	SNU8	8.1
Ovary	TOV112D	7.6
Ovary	TOV21G	8.5
Ovary	TYKNU	7
Pancreas	ASPC1	8.9
Pancreas	BXPC3	8.5
Pancreas	CAPAN1	8
Pancreas	CAPAN2	8.3
Pancreas	CFPAC1	8.6
Pancreas	DANG	7.8
Pancreas	HPAC	9.9
Pancreas	HPAFII	8.8
Pancreas	HS766T	9.2
Pancreas	HUPT3	7.6
Pancreas	HUPT4	8.4
Pancreas	KCIMOH1	8.8
Pancreas	KLM1	8.7
Pancreas	KP2	8.9
Pancreas	KP3	8.9
Pancreas	KP4	9
Pancreas	L33	8.6
Pancreas	MIAPACA2	7.9
Pancreas	PANC0203	8.6
Pancreas	PANC0213	8.7
Pancreas	PANC0327	7.8
Pancreas	PANC0403	8.8
Pancreas	PANC0504	8.6
Pancreas	PANC0813	8.2
Pancreas	PANC1005	8.1
Pancreas	PANC1	8
Pancreas	PATU8902	7.7
Pancreas	PATU8988S	7.2
Pancreas	PATU8988T	7.1
Pancreas	PK1	8.5
Pancreas	PK45H	7.7
Pancreas	PK59	9.2
Pancreas	PL45	8.1
Pancreas	PSN1	8.9
Pancreas	QGP1	7.3
Pancreas	SNU213	8.7
Pancreas	SNU324	7.9
Pancreas	SNU410	8.3
Pancreas	SU8686	9
Pancreas	SUIT2	8
Pancreas	SW1990	7.8
Pancreas	T3M4	9.2
Pancreas	TCCPAN2	8.1
Pancreas	YAPC	8.5
Pleura	ACCMESO1	8
Pleura	DM3	7.1
Pleura	ISTMES1	8
Pleura	ISTMES2	8.1
Pleura	JL1	8.2
Pleura	MPP89	8.3
Pleura	MSTO211H	7.1
Pleura	NCIH2052	8.6
Pleura	NCIH2452	8.1
Pleura	NCIH28	6.5
Prostate	22RV1	7.1
Prostate	DU145	7.2
Prostate	LNCAPCLONEFGC	6.9
Prostate	MDAPCA2B	8.2
Prostate	NCIH660	8.1
Prostate	PC3	7.7
Prostate	VCAP	8
Salivary gland	A253	8.8
Salivary gland	YD15	8
Skin	A101D	7.5
Skin	A2058	7.5
Skin	A375	7.1
Skin	C32	6.8
Skin	CHL1	7.4
Skin	CJM	9.3
Skin	COLO679	6.8
Skin	COLO741	7.1
Skin	COLO783	8.1
Skin	COLO792	7.4
Skin	COLO800	8
Skin	COLO818	8.2
Skin	COLO829	8.1
Skin	COLO849	7.5
Skin	G361	7.4
Skin	GRM	8.9
Skin	HMCB	7.5
Skin	HS294T	7.7
Skin	HS600T	8.6
Skin	HS688AT	7.6
Skin	HS695T	7.9
Skin	HS839T	7.8
Skin	HS852T	7.6
Skin	HS895T	7.4
Skin	HS934T	8.3
Skin	HS936T	7
Skin	HS939T	7.4
Skin	HS940T	8.6
Skin	HS944T	6.9
Skin	HT144	8
Skin	IGR1	7.5
Skin	IGR37	6.4
Skin	IGR39	8.1
Skin	IPC298	7.1
Skin	K029AX	7.3
Skin	LOXIMVI	7.1
Skin	MALME3M	7
Skin	MDAMB435S	8
Skin	MELHO	7.1
Skin	MELJUSO	7.4
Skin	MEWO	7.6
Skin	RPMI7951	8.8
Skin	RVH421	8.2
Skin	SH4	8.5
Skin	SKMEL1	7.1
Skin	SKMEL24	7.4
Skin	SKMEL28	6.8
Skin	SKMEL2	7.4
Skin	SKMEL30	7.6
Skin	SKMEL31	8
Skin	SKMEL3	7.6
Skin	SKMEL5	7.3
Skin	UACC257	6.9
Skin	UACC62	7.4
Skin	WM115	7.8
Skin	WM1799	8.1
Skin	WM2664	7.2
Skin	WM793	8.5
Skin	WM88	8.2
Skin	WM983B	8.2
Small intestine	HUTU80	7.5
Soft tissue	A204	7.6
Soft tissue	G401	8.2
Soft tissue	G402	7.8
Soft tissue	GCT	7.7
Soft tissue	HS729	7.7
Soft tissue	HT1080	6.8
Soft tissue	KYM1	7.9
Soft tissue	MESSA	9.1
Soft tissue	RD	7.2
Soft tissue	RH30	6.5
Soft tissue	RH41	7.8
Soft tissue	RKN	8.6
Soft tissue	S117	8.4
Soft tissue	SJRH30	8
Soft tissue	SKLMS1	7.6
Soft tissue	SKUT1	8.5
Soft tissue	TE125T	8.6
Soft tissue	TE159T	9.2
Soft tissue	TE441T	9.3
Soft tissue	TE617T	9.6
Stomach	2313287	9.3
Stomach	AGS	8.1
Stomach	AZ521	7.5
Stomach	ECC10	7.7
Stomach	ECC12	9.3
Stomach	FU97	8.3
Stomach	GCIY	7.8
Stomach	GSS	8.1
Stomach	GSU	7.7
Stomach	HGC27	7
Stomach	HS746T	7.9
Stomach	HUG1N	7.9
Stomach	IM95	7
Stomach	KATOIII	7.6
Stomach	KE39	7.8
Stomach	LMSU	7
Stomach	MKN1	9.2
Stomach	MKN45	9.2
Stomach	MKN74	8.7
Stomach	MKN7	9
Stomach	NCCSTCK140	9.9
Stomach	NCIN87	7.8
Stomach	NUGC2	9.5
Stomach	NUGC3	9
Stomach	NUGC4	7.3
Stomach	OCUM1	7.4
Stomach	RERFGC1B	8.9
Stomach	SH10TC	8.2
Stomach	SNU16	7.5
Stomach	SNU1	9.1
Stomach	SNU216	10.7
Stomach	SNU520	5.8
Stomach	SNU5	8.5
Stomach	SNU601	8.4
Stomach	SNU620	8.5
Stomach	SNU668	9.7
Stomach	SNU719	7.8
Stomach	TGBC11TKB	7.7
Thyroid	8305C	8.5
Thyroid	8505C	8.6
Thyroid	BCPAP	9.8
Thyroid	BHT101	8.2
Thyroid	CAL62	8.5
Thyroid	CGTHW1	8.3
Thyroid	FTC133	7.6
Thyroid	FTC238	8
Thyroid	ML1	8.1
Thyroid	SW579	7.9
Thyroid	TT2609C02	8
Thyroid	TT	7.4
Upper aerodigestive tract	BHY	9.9
Upper aerodigestive tract	BICR16	8.1
Upper aerodigestive tract	BICR18	9.1
Upper aerodigestive tract	BICR22	9
Upper aerodigestive tract	BICR31	8.8
Upper aerodigestive tract	BICR56	9.5
Upper aerodigestive tract	BICR6	9
Upper aerodigestive tract	CAL27	9.3
Upper aerodigestive tract	CAL33	9.9
Upper aerodigestive tract	DETROIT562	8.4
Upper aerodigestive tract	FADU	9.1
Upper aerodigestive tract	HS840T	8
Upper aerodigestive tract	HSC2	9.1
Upper aerodigestive tract	HSC3	7.8
Upper aerodigestive tract	HSC4	9.5
Upper aerodigestive tract	PECAPJ15	9.1
Upper aerodigestive tract	PECAPJ34CLONEC12	8.8
Upper aerodigestive tract	PECAPJ41CLONED2	7.9
Upper aerodigestive tract	PECAPJ49	8.5
Upper aerodigestive tract	SCC15	9
Upper aerodigestive tract	SCC25	8.4
Upper aerodigestive tract	SCC4	8.3
Upper aerodigestive tract	SCC9	9
Upper aerodigestive tract	SNU1076	9.3
Upper aerodigestive tract	SNU1214	8.6
Upper aerodigestive tract	SNU46	8.1
Upper aerodigestive tract	SNU899	9.3
Upper aerodigestive tract	YD10B	9.2
Upper aerodigestive tract	YD38	8.5
Upper aerodigestive tract	YD8	8.4
Urinary tract	5637	7.4
Urinary tract	639V	8.5
Urinary tract	647V	8.4
Urinary tract	BC3C	9.5
Urinary tract	BFTC905	8.5
Urinary tract	CAL29	8.8
Urinary tract	HS172T	7.8
Urinary tract	HT1197	8.2
Urinary tract	HT1376	9
Urinary tract	J82	8.1
Urinary tract	JMSU1	7.5
Urinary tract	KMBC2	9
Urinary tract	KU1919	8.6
Urinary tract	RT11284	9.4
Urinary tract	RT112	9.7
Urinary tract	RT4	8.5
Urinary tract	SCABER	8.1
Urinary tract	SW1710	8.1
Urinary tract	SW780	9.5
Urinary tract	T24	8.8
Urinary tract	TCCSUP	7
Urinary tract	UMUC1	9.4
Urinary tract	UMUC3	7.5
Urinary tract	VMCUB1	8.4

> The Human Protein Atlas (HPA)

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Tissue	Expression Level (TPM)
Adipose tissue	17.4
Adrenal gland	11.2
Appendix	33.8
Bone marrow	11.2
Breast	15.1
Cerebral cortex	9.9
Cervix, uterine	18.6
Colon	10.7
Duodenum	9.5
Endometrium	21.3
Epididymis	8.8
Esophagus	17
Fallopian tube	19.5
Gallbladder	17.7
Heart muscle	7.4
Kidney	10.9
Liver	5.8
Lung	19.6
Lymph node	45.3
Ovary	19.2
Pancreas	2.5
Parathyroid gland	27.6
Placenta	43.2
Prostate	15.8
Rectum	13.7
Salivary gland	5.2
Seminal vesicle	13.2
Skeletal muscle	5.5
Skin	17.3
Small intestine	10.6
Smooth muscle	19.3
Spleen	40.3
Stomach	14.6
Testis	16.1
Thyroid gland	23.5
Tonsil	40.3
Urinary bladder	21.2

> Text Mining based Expression

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PMID	Expression	Cancer	Evidence
24282087	overexpression	Osteosarcoma	In the current study, we found that SRC-3, but not SRC-1 and SRC-2, was dramatically up-regulated in human osteosarcoma tissues, compared with adjacent normal tissues.
24304549	overexpression	Breast Carcinoma	Moreover, significant higher transcript levels of PLAC1 were found only in ERα-positive human breast cancer samples which also show a NCOA3 overexpression.
26082485	overexpression	Hepatocellular Carcinoma	In addition, SRC-1 and SRC-3 were co-overexpressed in 47.5% of HCC specimens, and they cooperated to promote HCC cell proliferation.
27370960	overexpression	B-Cell Non-Hodgkin Lymphoma	We also verified that SRC-3 was overexpressed in B-cell NHL in both cell lines and lymph node samples from patients.
24875297	overexpression	Chondrosarcoma	Significant higher levels of SRC-1 and SRC-3 were detected in MDC and PDC when compared to WDC.
24584933	overexpression	Breast Carcinoma; Lung Carcinoma; Prostate Carcinoma; Bladder Carcinoma	Multiple studies have shown that steroid receptor coactivator-3 (SRC-3) is upregulated and promotes cell proliferation in several human cancers, including breast, lung, and prostate carcinoma. Here, we reported that overexpression of SRC-3 accelerated UBC cell growth, accompanied by the increased expression of genes involved in glycolysis.
24134957	overexpression	Breast Carcinoma; Prostate Carcinoma; Thyroid Gland Carcinoma; Malignant Bone Neoplasm	Previous studies have demonstrated overexpression of steroid receptor coactivator-3 (SRC-3) in many cancers, such as breast cancer, prostate cancer, thyroid cancer, functioning in the regulation of cancer cell proliferation, invasion, and metastasis. The results showed that in normal bone tissue, levels of SRC-3 are almost negative (score=0), the total positivity (score=1-3) of SRC-3 immunoreactivities in bone cancers was 74.47%.
23650284	overexpression	Castration-Resistant Prostate Carcinoma; PTEN-Negative Human Prostate Cancer	We documented elevated SRC-3 in human CRPC and in PTEN-negative human prostate cancer.
23274413	aberrant expression	Breast Carcinoma	These include the regulation of expression and intracellular positioning of nucleoporin and nucleophosmin; downregulation of steroid receptor coactivator-3 (SRC-3) and its downstream proteins; upregulation of death inducer-obliterator (DIO-1); downregulation of HERG potassium channel; as well as induction of reactive oxygen species (ROS) accumulation.
21454665	overexpression	Synovial Sarcoma	The increase of NCOA3 is essential for SYT-SSX1-mediated synovial sarcoma formation.
20852035	overexpression	Non-Small Cell Lung Carcinoma	The results showed that of these 48 cases, 18 (37.5%) exhibited high levels of SRC-3 immunoreactivity, 23 (47.9%) exhibited moderate levels of SRC-3 immunoreactivity, and 7 (14.6%) were negative; thus, the total frequency of SRC-3 overexpression was 85.4% (41/48).
20137343	aberrant expression	Lung Adenocarcinoma	Overexpression of SRC-3 was found in A549 cells, whereas the SRC-3 protein and mRNA expression levels were significantly downregulated in A549 cells induced by GA in a dose-dependent manner.
28521488	Underexpression	Non-Small Cell Lung Carcinoma	The results of the present study demonstrate that high expression of microRNA (miR)-137 and low expression of steroid receptor coactivator-3 (SRC3) had a significant negative correlation in 40 NSCLC tissue samples.
27831559	Overexpression	Taxol-resistent Breast Carcinoma	In this study, nuclear receptor coactivator 3 (NCOA3) was found to be significantly increased in taxol-resistant breast cancer tissues and cells.
27781415	Overexpression	Esophageal Squamous Cell Carcinoma	SRC-3 overexpression is clinically and functionally relevant to the progression of human ESCC, and might be a useful molecular target for ESCC prognosis and treatment.
27109102	Overexpression	Breast Carcinoma	Increased expression of NCOA3 was associated with poor prognosis and higher levels of XBP1-S in breast cancer tissues.

Summary
Symbol	NCOA3
Name	nuclear receptor coactivator 3
Aliases	ACTR; p/CIP; TRAM-1; CAGH16; TNRC16; KAT13B; SRC-3; SRC3; receptor-associated coactivator 3; thyroid hormone ......
Location	20q13.12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

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Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.406	1.8e-17	2.7	36.9	60.4	Gain
BRCA	Breast invasive carcinoma	1075	0.518	6.14e-75	5.5	48.9	45.6	Gain
CESC	Cervical and endocervical cancers	292	0.406	5.43e-13	5.8	54.5	39.7	Gain
COAD	Colon adenocarcinoma	449	0.523	7.55e-33	0	27.6	72.4	Gain
ESCA	Esophageal carcinoma	183	0.137	0.0638	2.2	32.8	65	Gain
GBM	Glioblastoma multiforme	147	0.383	1.65e-06	2	61.2	36.7	Gain
HNSC	Head and Neck squamous cell carcinoma	514	0.352	2e-16	6.4	55.8	37.7	Gain
KIRC	Kidney renal clear cell carcinoma	525	-0.119	0.00626	0	77	23	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.45	8.8e-16	0.3	64.6	35.1	Gain
LAML	Acute Myeloid Leukemia	166	0.214	0.0056	1.8	98.2	0	Neutral
LGG	Brain Lower Grade Glioma	513	0.17	0.00011	1.2	90.3	8.6	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.283	3.78e-08	3.6	64	32.4	Neutral
LUAD	Lung adenocarcinoma	512	0.291	2e-11	14.3	43.4	42.4	Gain
LUSC	Lung squamous cell carcinoma	498	0.359	1.3e-16	10.4	38	51.6	Gain
OV	Ovarian serous cystadenocarcinoma	300	0.439	1.37e-15	3	28.7	68.3	Gain
PAAD	Pancreatic adenocarcinoma	177	0.148	0.0492	2.3	72.3	25.4	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.09	0.253	2.5	91.4	6.2	Neutral
PRAD	Prostate adenocarcinoma	491	0.228	3.3e-07	2.2	90	7.7	Neutral
READ	Rectum adenocarcinoma	164	0.444	2.63e-09	0	11	89	Gain
SARC	Sarcoma	255	0.485	1.77e-16	5.5	55.7	38.8	Gain
SKCM	Skin Cutaneous Melanoma	367	0.215	3.3e-05	1.9	48	50.1	Gain
STAD	Stomach adenocarcinoma	413	0.447	1.06e-21	0.7	32.4	66.8	Gain
TGCT	Testicular Germ Cell Tumors	150	0.113	0.167	8	63.3	28.7	Neutral
THCA	Thyroid carcinoma	497	0.076	0.0909	0	97.6	2.4	Neutral
THYM	Thymoma	119	0.165	0.0726	0.8	90.8	8.4	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.442	4.81e-27	1.9	70.2	27.9	Neutral

Summary
Symbol	NCOA3
Name	nuclear receptor coactivator 3
Aliases	ACTR; p/CIP; TRAM-1; CAGH16; TNRC16; KAT13B; SRC-3; SRC3; receptor-associated coactivator 3; thyroid hormone ......
Location	20q13.12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

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Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.387	4.94e-18	17	408	-0.021	0.000405	NS/NA
BRCA	Breast invasive carcinoma	-0.289	4.88e-18	83	785	-0.003	0.00512	NS/NA
CESC	Cervical and endocervical cancers	-0.337	1.59e-09	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.472	0	19	297	-0.004	0.0766	NS/NA
ESCA	Esophageal carcinoma	-0.347	8.32e-07	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.249	0.0457	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.176	4.02e-05	20	522	-0.039	0.000816	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.099	0.0681	24	319	0.033	0.68	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.39	4.25e-12	23	275	0.003	0.344	NS/NA
LAML	Acute Myeloid Leukemia	-0.113	0.141	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.074	0.089	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.269	3.23e-08	41	373	-0.095	1.78e-34	NS/NA
LUAD	Lung adenocarcinoma	-0.179	8.52e-05	21	456	0.023	0.588	NS/NA
LUSC	Lung squamous cell carcinoma	-0.472	0	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.467	0.213	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.152	0.0401	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.073	0.322	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.204	2.2e-06	35	498	0.002	0.0023	NS/NA
READ	Rectum adenocarcinoma	-0.372	0.000143	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.268	1.1e-05	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.157	0.000634	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.293	1.01e-08	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.325	3.79e-05	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.132	0.0018	50	509	0.001	0.264	NS/NA
THYM	Thymoma	-0.42	1.9e-06	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.194	2.65e-05	34	431	-0.063	1e-19	NS/NA

Summary
Symbol	NCOA3
Name	nuclear receptor coactivator 3
Aliases	ACTR; p/CIP; TRAM-1; CAGH16; TNRC16; KAT13B; SRC-3; SRC3; receptor-associated coactivator 3; thyroid hormone ......
Location	20q13.12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA)

[ TOP ]

Cancer	Full Name	# Sample	Median (abundance)	MAD (abundance)
THCA	Thyroid carcinoma	224	0.994	0.177

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	2	Medium
Appendix	2	Medium
Bone marrow	2	Medium
Breast	2	Medium
Bronchus	2	Medium
Caudate	0	Not detected
Cerebellum	2	Medium
Cerebral cortex	2	Medium
Cervix, uterine	2	Medium
Colon	2	Medium
Duodenum	2	Medium
Endometrium	2	Medium
Epididymis	2	Medium
Esophagus	2	Medium
Fallopian tube	2	Medium
Gallbladder	2	Medium
Heart muscle	2	Medium
Hippocampus	1	Low
Kidney	2	Medium
Liver	2	Medium
Lung	2	Medium
Lymph node	2	Medium
Nasopharynx	2	Medium
Oral mucosa	2	Medium
Ovary	2	Medium
Pancreas	2	Medium
Parathyroid gland	2	Medium
Placenta	2	Medium
Prostate	2	Medium
Rectum	2	Medium
Salivary gland	2	Medium
Seminal vesicle	2	Medium
Skeletal muscle	1	Low
Skin	2	Medium
Small intestine	2	Medium
Smooth muscle	1	Low
Soft tissue	2	Medium
Spleen	2	Medium
Stomach	2	Medium
Testis	2	Medium
Thyroid gland	2	Medium
Tonsil	2	Medium
Urinary bladder	2	Medium
Vagina	2	Medium

Summary
Symbol	NCOA3
Name	nuclear receptor coactivator 3
Aliases	ACTR; p/CIP; TRAM-1; CAGH16; TNRC16; KAT13B; SRC-3; SRC3; receptor-associated coactivator 3; thyroid hormone ......
Location	20q13.12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

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Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.0142	Significant	24476821
BRCA	Breast invasive carcinoma	521	3.45e-14	Significant	23000897
COAD	Colon adenocarcinoma	149	6.08e-08	Significant	22810696
GBM	Glioblastoma multiforme	157	0.0111	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	0.000603	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.00312	Significant	26536169
LGG	Brain Lower Grade Glioma	513	0.439	NS	26824661
LUAD	Lung adenocarcinoma	230	0.0886	NS	25079552
LUSC	Lung squamous cell carcinoma	178	0.214	NS	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.0235	Significant	21720365
PRAD	Prostate adenocarcinoma	333	0.148	NS	26544944
READ	Rectum adenocarcinoma	67	0.000237	Significant	22810696
SKCM	Skin Cutaneous Melanoma	315	0.405	NS	26091043
STAD	Stomach adenocarcinoma	277	1.71e-12	Significant	25079317
THCA	Thyroid carcinoma	391	0.416	NS	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.181	NS	23636398

> Overall survival

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Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	1.136	0.549	NS
BRCA	Breast invasive carcinoma	1079	1.88	0.0119	Shorter
CESC	Cervical and endocervical cancers	291	1.481	0.24	NS
COAD	Colon adenocarcinoma	439	1.049	0.866	NS
ESCA	Esophageal carcinoma	184	1.527	0.213	NS
GBM	Glioblastoma multiforme	158	1.026	0.92	NS
HNSC	Head and Neck squamous cell carcinoma	518	1.219	0.284	NS
KIRC	Kidney renal clear cell carcinoma	531	0.433	2e-04	Longer
KIRP	Kidney renal papillary cell carcinoma	287	3.005	0.00923	Shorter
LAML	Acute Myeloid Leukemia	149	1.228	0.511	NS
LGG	Brain Lower Grade Glioma	511	0.992	0.974	NS
LIHC	Liver hepatocellular carcinoma	365	1.149	0.57	NS
LUAD	Lung adenocarcinoma	502	1.136	0.537	NS
LUSC	Lung squamous cell carcinoma	494	1.284	0.194	NS
OV	Ovarian serous cystadenocarcinoma	303	1.433	0.0847	NS
PAAD	Pancreatic adenocarcinoma	177	1.978	0.0244	Shorter
PCPG	Pheochromocytoma and Paraganglioma	179	577662396.704	0.0488	Shorter
PRAD	Prostate adenocarcinoma	497	0.616	0.699	NS
READ	Rectum adenocarcinoma	159	1.039	0.954	NS
SARC	Sarcoma	259	1.354	0.264	NS
SKCM	Skin Cutaneous Melanoma	459	0.625	0.0171	Longer
STAD	Stomach adenocarcinoma	388	1.172	0.488	NS
TGCT	Testicular Germ Cell Tumors	134	1449341136.236	0.11	NS
THCA	Thyroid carcinoma	500	0.626	0.518	NS
THYM	Thymoma	119	1.223	0.807	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	1.588	0.0974	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	-0.035	0.487	NS
BRCA	Breast invasive carcinoma	1071	0.067	0.0283	Higher
CESC	Cervical and endocervical cancers	167	0.073	0.346	NS
COAD	Colon adenocarcinoma	445	0.099	0.0364	Higher
ESCA	Esophageal carcinoma	162	-0.025	0.757	NS
HNSC	Head and Neck squamous cell carcinoma	448	-0.014	0.764	NS
KIRC	Kidney renal clear cell carcinoma	531	-0.177	4.3e-05	Lower
KIRP	Kidney renal papillary cell carcinoma	260	0.051	0.41	NS
LIHC	Liver hepatocellular carcinoma	347	0.052	0.335	NS
LUAD	Lung adenocarcinoma	507	0.06	0.179	NS
LUSC	Lung squamous cell carcinoma	497	-0.006	0.892	NS
OV	Ovarian serous cystadenocarcinoma	302	0.09	0.12	NS
PAAD	Pancreatic adenocarcinoma	176	0.104	0.17	NS
READ	Rectum adenocarcinoma	156	0.123	0.127	NS
SKCM	Skin Cutaneous Melanoma	410	-0.015	0.766	NS
STAD	Stomach adenocarcinoma	392	0.095	0.0614	NS
TGCT	Testicular Germ Cell Tumors	81	-0.166	0.139	NS
THCA	Thyroid carcinoma	499	-0.094	0.0367	Lower
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.067	0.134	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	0.011	0.857	NS
HNSC	Head and Neck squamous cell carcinoma	498	-0.092	0.0409	Lower
KIRC	Kidney renal clear cell carcinoma	525	-0.181	2.88e-05	Lower
LGG	Brain Lower Grade Glioma	514	0.037	0.403	NS
LIHC	Liver hepatocellular carcinoma	366	0.144	0.00577	Higher
OV	Ovarian serous cystadenocarcinoma	296	0.129	0.0268	Higher
PAAD	Pancreatic adenocarcinoma	176	0.099	0.192	NS
STAD	Stomach adenocarcinoma	406	-0.018	0.716	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.259	1.32e-09	Higher

Summary
Symbol	NCOA3
Name	nuclear receptor coactivator 3
Aliases	ACTR; p/CIP; TRAM-1; CAGH16; TNRC16; KAT13B; SRC-3; SRC3; receptor-associated coactivator 3; thyroid hormone ......
Location	20q13.12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	NCOA3
Name	nuclear receptor coactivator 3
Aliases	ACTR; p/CIP; TRAM-1; CAGH16; TNRC16; KAT13B; SRC-3; SRC3; receptor-associated coactivator 3; thyroid hormone ......
Location	20q13.12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for NCOA3.

Summary
Symbol	NCOA3
Name	nuclear receptor coactivator 3
Aliases	ACTR; p/CIP; TRAM-1; CAGH16; TNRC16; KAT13B; SRC-3; SRC3; receptor-associated coactivator 3; thyroid hormone ......
Location	20q13.12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
24584933	Breast Carcinoma; Lung Carcinoma; Prostate Carcinoma; Bladder Carcinoma	partner	Glut1	positive correlation	The positive correlation of expression levels between SRC-3 and Glut1 proteins was demonstrated in human UBC patient samples.
21454665	Synovial Sarcoma	upstream	SYT-SSX1	positive regulation	SYT-SSX1 does so by increasing the sumoylation of NCOA3 through interaction with a SUMO E3 ligase, PIASy, as well as the sumoylation of NEMO.
28521488	Non-Small Cell Lung Carcinoma	upstream	miR-137	Negative regulation	In conclusion, the results of the present study suggest that miR-137 suppresses NSCLC cell proliferation by partially targeting SRC3.
27831559	Taxol-resistent Breast Carcinoma	upstream	miR-17; miR-20	Negative regulation	Furthermore, by luciferase reporter assays, we further validated that both miR-17 and miR-20b directly binded the 3'-untranslated region of NCOA3 mRNA and inhibited its expression in breast cancer cells.
27109102	Breast Carcinoma	upstream	XBP1	Positive regulation	Here we show that NCOA3 is a transcriptional target of XBP1. We observed increased expression of NCOA3 during conditions of UPR and oestrogen (E2) stimulation. Further investigations revealed a role for the IRE1-XBP1 axis in the induction of NCOA3 during UPR and oestrogen signalling. We identify a novel role for NCOA3 in activation of PERK-ATF4 axis during UPR where knockdown of NCOA3 compromised the optimal activation of the PERK-ATF4 pathway. We found that NCOA3 is required for induction of XBP1 during E2 stimulation and uncover a positive feedback regulatory loop that maintains high levels of NCOA3 and XBP1 in breast cancer.