CR2Cancer

Summary
Symbol	NCOA4
Name	nuclear receptor coactivator 4
Aliases	ARA70; RFG; ELE1; PTC3; DKFZp762E1112; RET-activating gene ELE1; 70 kDa AR-activator; 70 kDa androgen recept ......
Location	10q11.22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

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Domain

PF12489 Nuclear coactivator

Function

Enhances the androgen receptor transcriptional activity in prostate cancer cells. Ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma.

Classification

Class	Modification	Substrate	Product	PubMed
#	#	#	#	#

> Gene Ontology [ TOP ]
Biological Process	GO:0006622 protein targeting to lysosome GO:0006623 protein targeting to vacuole GO:0007034 vacuolar transport GO:0007041 lysosomal transport GO:0007548 sex differentiation GO:0008406 gonad development GO:0008584 male gonad development GO:0009755 hormone-mediated signaling pathway GO:0030518 intracellular steroid hormone receptor signaling pathway GO:0030521 androgen receptor signaling pathway GO:0030522 intracellular receptor signaling pathway GO:0043401 steroid hormone mediated signaling pathway GO:0045137 development of primary sexual characteristics GO:0046546 development of primary male sexual characteristics GO:0046661 male sex differentiation GO:0048545 response to steroid hormone GO:0048608 reproductive structure development GO:0061458 reproductive system development GO:0061462 protein localization to lysosome GO:0071383 cellular response to steroid hormone stimulus GO:0071396 cellular response to lipid GO:0071407 cellular response to organic cyclic compound GO:0072665 protein localization to vacuole GO:0072666 establishment of protein localization to vacuole
Molecular Function	GO:0003713 transcription coactivator activity GO:0035257 nuclear hormone receptor binding GO:0035258 steroid hormone receptor binding GO:0050681 androgen receptor binding GO:0051427 hormone receptor binding
Cellular Component	GO:0005767 secondary lysosome GO:0005776 autophagosome GO:0044754 autolysosome

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	-

Summary
Symbol	NCOA4
Name	nuclear receptor coactivator 4
Aliases	ARA70; RFG; ELE1; PTC3; DKFZp762E1112; RET-activating gene ELE1; 70 kDa AR-activator; 70 kDa androgen recept ......
Location	10q11.22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]

> Catalogue of Somatic Mutations in Cancer (COSMIC)

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COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM137537	c.799T>C	p.S267P	Substitution - Missense	Skin
COSM30499	c.441G>A	p.L147L	Substitution - coding silent	Kidney

> Text Mining based Variations

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PMID	Variation	Cancer	Evidence
26078337	mutation	Colorectal Carcinoma	Through comprehensive genomic profiling we prospectively identified 6 RET fusion kinases, including two novel fusions of CCDC6-RET and NCOA4-RET, in metastatic colorectal cancer (CRC) patients.
23327964	mutation	Papillary Thyroid Carcinoma	BRAF T1799A mutation and RET/PTC3 rearrangement in patients suggests a poorer prognosis than the negative one.
22457234	mutation	Papillary Thyroid Carcinoma	In total, 46/70 (66%) cases carried a BRAF mutation and/or a RET/PTC rearrangement. A BRAF mutation was detected in 26 tumors, RET/PTC1 in 20 cases, and RET/PTC3 in four cases.
21674964	mutation	Papillary Thyroid Carcinoma	It was established that induction of both, RET/PTC1 and RET/PTC3 rearrangements was present only in carcinoma samples.
20839015	mutation	Papillary Thyroid Carcinoma	Several cytoskeletal protein species showed quantitative changes in tumors and lymph node metastases harboring RET/PTC1 or RET/PTC3.
19765726	mutation	Papillary Thyroid Carcinoma	The primary tumor genotype in 217 patients with papillary thyroid cancer was determined for six common somatic genetic alterations (RET/PTC1, RET/PTC3, and NTRK1 rearrangements, and BRAF V600E, KRAS, and NRAS hotspot mutations) by PCR and direct sequencing, and nested PCR.
16630482	mutation	Papillary Thyroid Carcinoma	(3) Fourteen PTCs (21.2%) expressed RET/PTC, including five cases expressing RET/PTC1 and nine cases expressing RET/PTC3.
12457448	mutation	Papillary Thyroid Carcinoma	The prevalence of RET/PTC activation in PTC is high and RET/PTC3 is the only type of activation identified in Hong Kong Chinese and is an important genetic event underlying the development of PTC in the population
11318605	mutation	Papillary Thyroid Carcinoma	More than 90% of PTC with RET rearrangement exhibit a PTC1 or PTC3 type of rearrangement with an inversion of the H4 or ELE1 gene, respectively, on chromosome 10.
10566678	mutation	Papillary Thyroid Carcinoma	A strong correlation was observed between the solid-follicular subtype of papillary carcinoma and the RET/PTC3 isoform: 19 of the 24 RET/PTC-positive solid-follicular carcinomas harbored a RET/PTC3 rearrangement, whereas only 5 had a RET/PTC1 rearrangement.

Summary
Symbol	NCOA4
Name	nuclear receptor coactivator 4
Aliases	ARA70; RFG; ELE1; PTC3; DKFZp762E1112; RET-activating gene ELE1; 70 kDa AR-activator; 70 kDa androgen recept ......
Location	10q11.22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM) [ TOP ]
There is no PTM data

Summary
Symbol	NCOA4
Name	nuclear receptor coactivator 4
Aliases	ARA70; RFG; ELE1; PTC3; DKFZp762E1112; RET-activating gene ELE1; 70 kDa AR-activator; 70 kDa androgen recept ......
Location	10q11.22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

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Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	7.826	7.282	-0.634	7.13e-05	Under
BRCA	Breast invasive carcinoma	112	1100	8.239	7.882	-0.468	1.36e-15	NS
CESC	Cervical and endocervical cancers	3	306	7.173	7.375	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	8.451	7.499	-1.051	1.27e-33	Under
ESCA	Esophageal carcinoma	11	185	8.334	8.038	-0.33	0.059	NS
GBM	Glioblastoma multiforme	5	166	7.247	7.237	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	8.27	7.672	-0.63	7.51e-10	Under
KIRC	Kidney renal clear cell carcinoma	72	534	8.649	8.306	-0.43	1.28e-08	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	8.402	7.916	-0.541	1.07e-05	NS
LAML	Acute Myeloid Leukemia	0	173	NA	9.469	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	7.688	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	8.508	7.799	-0.702	1.47e-10	Under
LUAD	Lung adenocarcinoma	59	517	8.326	7.713	-0.621	3.11e-16	Under
LUSC	Lung squamous cell carcinoma	51	501	8.199	7.657	-0.6	4.3e-10	Under
OV	Ovarian serous cystadenocarcinoma	0	307	NA	7.801	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	7.668	7.364	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	7.225	7.152	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	8.538	8.427	-0.222	0.0105	NS
READ	Rectum adenocarcinoma	10	167	8.497	7.399	-1.136	1.71e-09	Under
SARC	Sarcoma	2	263	7.975	7.11	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	7.278	7.121	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	8.634	8.088	-0.713	2.25e-15	Under
TGCT	Testicular Germ Cell Tumors	0	156	NA	7.15	NA	NA	NA
THCA	Thyroid carcinoma	59	509	7.675	7.627	-0.059	0.365	NS
THYM	Thymoma	2	120	7.898	7.71	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	7.389	6.907	-0.491	1.61e-05	NS

> Cancer Cell Line Encyclopedia (CCLE)

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Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	12.2
Autonomic ganglia	CHP212	12.2
Autonomic ganglia	IMR32	11.7
Autonomic ganglia	KELLY	11.8
Autonomic ganglia	KPNRTBM1	12.2
Autonomic ganglia	KPNSI9S	12.1
Autonomic ganglia	KPNYN	12.1
Autonomic ganglia	MHHNB11	11.8
Autonomic ganglia	NB1	11.9
Autonomic ganglia	NH6	12
Autonomic ganglia	SHSY5Y	11
Autonomic ganglia	SIMA	12
Autonomic ganglia	SKNAS	12.6
Autonomic ganglia	SKNBE2	12.4
Autonomic ganglia	SKNDZ	11.7
Autonomic ganglia	SKNFI	11.4
Autonomic ganglia	SKNSH	11.6
Biliary tract	HUCCT1	12.3
Biliary tract	HUH28	12
Biliary tract	SNU1079	12.1
Biliary tract	SNU1196	12.2
Biliary tract	SNU245	12.7
Biliary tract	SNU308	11.5
Biliary tract	SNU478	12.4
Bone	143B	12.5
Bone	A673	11.4
Bone	CADOES1	12
Bone	CAL78	12.4
Bone	G292CLONEA141B1	11.7
Bone	HOS	12.2
Bone	HS706T	12.4
Bone	HS737T	12.4
Bone	HS819T	12.4
Bone	HS821T	12.6
Bone	HS822T	12.4
Bone	HS863T	12.3
Bone	HS870T	12.5
Bone	HS888T	12.2
Bone	MG63	12.5
Bone	MHHES1	11.6
Bone	OUMS27	12.4
Bone	RDES	11.1
Bone	SJSA1	12.5
Bone	SKES1	11.3
Bone	SKNMC	10.4
Bone	SW1353	12.5
Bone	T173	12.4
Bone	TC71	11.7
Bone	U2OS	12.2
Breast	AU565	12
Breast	BT20	11.6
Breast	BT474	12
Breast	BT483	12.1
Breast	BT549	11.9
Breast	CAL120	12.2
Breast	CAL148	12.1
Breast	CAL51	11.9
Breast	CAL851	11.4
Breast	CAMA1	12
Breast	DU4475	12.9
Breast	EFM192A	11.9
Breast	EFM19	12
Breast	EVSAT	10.8
Breast	HCC1143	12.1
Breast	HCC1187	12.1
Breast	HCC1395	12.1
Breast	HCC1419	11.5
Breast	HCC1428	12.4
Breast	HCC1500	12.2
Breast	HCC1569	12.5
Breast	HCC1599	12.5
Breast	HCC1806	12.5
Breast	HCC1937	12.5
Breast	HCC1954	11.6
Breast	HCC202	11.7
Breast	HCC2157	12.4
Breast	HCC2218	12.5
Breast	HCC38	12.2
Breast	HCC70	11.8
Breast	HDQP1	12.3
Breast	HMC18	11.5
Breast	HS274T	12.4
Breast	HS281T	12.2
Breast	HS343T	12.2
Breast	HS578T	11.1
Breast	HS606T	12.3
Breast	HS739T	12.3
Breast	HS742T	12.3
Breast	JIMT1	12.6
Breast	KPL1	11.8
Breast	MCF7	11.8
Breast	MDAMB134VI	12.9
Breast	MDAMB157	11.7
Breast	MDAMB175VII	12.5
Breast	MDAMB231	12.1
Breast	MDAMB361	11.7
Breast	MDAMB415	12.2
Breast	MDAMB436	12.2
Breast	MDAMB453	11.3
Breast	MDAMB468	12.5
Breast	SKBR3	12.3
Breast	T47D	12.4
Breast	UACC812	11.8
Breast	UACC893	11.6
Breast	YMB1	11.7
Breast	ZR751	11.8
Breast	ZR7530	12.6
Central nervous system	1321N1	11.6
Central nervous system	42MGBA	12.2
Central nervous system	8MGBA	11.2
Central nervous system	A172	12.1
Central nervous system	AM38	12.4
Central nervous system	BECKER	12.3
Central nervous system	CAS1	11.9
Central nervous system	CCFSTTG1	12.3
Central nervous system	D283MED	11.4
Central nervous system	D341MED	12.9
Central nervous system	DAOY	11.7
Central nervous system	DBTRG05MG	11.9
Central nervous system	DKMG	11.9
Central nervous system	GAMG	11.6
Central nervous system	GB1	12.4
Central nervous system	GI1	11.7
Central nervous system	GMS10	11.6
Central nervous system	GOS3	11.5
Central nervous system	H4	12.3
Central nervous system	HS683	11.6
Central nervous system	KALS1	12.3
Central nervous system	KG1C	12.6
Central nervous system	KNS42	11.4
Central nervous system	KNS60	12.3
Central nervous system	KNS81	11.3
Central nervous system	KS1	12.5
Central nervous system	LN18	11.6
Central nervous system	LN229	11.7
Central nervous system	M059K	11.5
Central nervous system	MOGGCCM	12
Central nervous system	MOGGUVW	11.5
Central nervous system	NMCG1	11.7
Central nervous system	ONS76	11.6
Central nervous system	SF126	12.2
Central nervous system	SF295	11.3
Central nervous system	SNB19	12
Central nervous system	SNU1105	11.5
Central nervous system	SNU201	11.8
Central nervous system	SNU466	11.8
Central nervous system	SNU489	11.3
Central nervous system	SNU626	11.1
Central nervous system	SNU738	11.4
Central nervous system	SW1088	12.4
Central nervous system	SW1783	12.1
Central nervous system	T98G	11.9
Central nervous system	TM31	13.3
Central nervous system	U118MG	11.7
Central nervous system	U138MG	11.5
Central nervous system	U251MG	12.1
Central nervous system	U87MG	11.9
Central nervous system	YH13	11.4
Central nervous system	YKG1	11.9
Endometrium	AN3CA	11.7
Endometrium	COLO684	11.4
Endometrium	EFE184	12.1
Endometrium	EN	12.1
Endometrium	ESS1	12
Endometrium	HEC108	12.7
Endometrium	HEC151	12.2
Endometrium	HEC1A	12.3
Endometrium	HEC1B	12.6
Endometrium	HEC251	12.5
Endometrium	HEC265	12.1
Endometrium	HEC50B	11.4
Endometrium	HEC59	12.9
Endometrium	HEC6	11.8
Endometrium	ISHIKAWAHERAKLIO02ER	12.2
Endometrium	JHUEM1	12.5
Endometrium	JHUEM2	12.2
Endometrium	JHUEM3	12.1
Endometrium	KLE	11.4
Endometrium	MFE280	10.2
Endometrium	MFE296	11.8
Endometrium	MFE319	12.3
Endometrium	RL952	12
Endometrium	SNGM	11.9
Endometrium	SNU1077	12.3
Endometrium	SNU685	11.8
Endometrium	TEN	12.7
Haematopoietic and lymphoid	697	12
Haematopoietic and lymphoid	A3KAW	12.3
Haematopoietic and lymphoid	A4FUK	11.6
Haematopoietic and lymphoid	ALLSIL	12.7
Haematopoietic and lymphoid	AML193	13.1
Haematopoietic and lymphoid	AMO1	11.9
Haematopoietic and lymphoid	BCP1	12.5
Haematopoietic and lymphoid	BDCM	12.3
Haematopoietic and lymphoid	BL41	12.5
Haematopoietic and lymphoid	BL70	12.5
Haematopoietic and lymphoid	BV173	12.2
Haematopoietic and lymphoid	CA46	12.7
Haematopoietic and lymphoid	CI1	12.6
Haematopoietic and lymphoid	CMK115	13
Haematopoietic and lymphoid	CMK86	13.2
Haematopoietic and lymphoid	CMK	13.4
Haematopoietic and lymphoid	CMLT1	12.5
Haematopoietic and lymphoid	COLO775	11.8
Haematopoietic and lymphoid	DAUDI	12.2
Haematopoietic and lymphoid	DB	12.3
Haematopoietic and lymphoid	DEL	12.2
Haematopoietic and lymphoid	DND41	12.5
Haematopoietic and lymphoid	DOHH2	12.4
Haematopoietic and lymphoid	EB1	12.2
Haematopoietic and lymphoid	EB2	12.1
Haematopoietic and lymphoid	EHEB	12.3
Haematopoietic and lymphoid	EJM	11.7
Haematopoietic and lymphoid	EM2	13.5
Haematopoietic and lymphoid	EOL1	13
Haematopoietic and lymphoid	F36P	12.9
Haematopoietic and lymphoid	GA10	12
Haematopoietic and lymphoid	GDM1	12.8
Haematopoietic and lymphoid	GRANTA519	12
Haematopoietic and lymphoid	HDLM2	12.3
Haematopoietic and lymphoid	HDMYZ	11.4
Haematopoietic and lymphoid	HEL9217	11.8
Haematopoietic and lymphoid	HEL	12
Haematopoietic and lymphoid	HH	11.5
Haematopoietic and lymphoid	HL60	12.7
Haematopoietic and lymphoid	HPBALL	12.6
Haematopoietic and lymphoid	HS604T	12.5
Haematopoietic and lymphoid	HS611T	12.4
Haematopoietic and lymphoid	HS616T	12.5
Haematopoietic and lymphoid	HS751T	12.1
Haematopoietic and lymphoid	HT	12.1
Haematopoietic and lymphoid	HTK	11.9
Haematopoietic and lymphoid	HUNS1	12.4
Haematopoietic and lymphoid	HUT102	12.6
Haematopoietic and lymphoid	HUT78	12.8
Haematopoietic and lymphoid	JEKO1	12.1
Haematopoietic and lymphoid	JK1	14
Haematopoietic and lymphoid	JM1	12
Haematopoietic and lymphoid	JURKAT	12.3
Haematopoietic and lymphoid	JURLMK1	11.9
Haematopoietic and lymphoid	JVM2	12.1
Haematopoietic and lymphoid	JVM3	12
Haematopoietic and lymphoid	K562	13
Haematopoietic and lymphoid	KARPAS299	11.2
Haematopoietic and lymphoid	KARPAS422	11.9
Haematopoietic and lymphoid	KARPAS620	12.3
Haematopoietic and lymphoid	KASUMI1	13.5
Haematopoietic and lymphoid	KASUMI2	12.4
Haematopoietic and lymphoid	KASUMI6	13.1
Haematopoietic and lymphoid	KCL22	12.5
Haematopoietic and lymphoid	KE37	12.6
Haematopoietic and lymphoid	KE97	12.1
Haematopoietic and lymphoid	KG1	13.2
Haematopoietic and lymphoid	KHM1B	12.2
Haematopoietic and lymphoid	KIJK	11.9
Haematopoietic and lymphoid	KMH2	11
Haematopoietic and lymphoid	KMM1	11.9
Haematopoietic and lymphoid	KMS11	12.1
Haematopoietic and lymphoid	KMS12BM	11.6
Haematopoietic and lymphoid	KMS18	12.2
Haematopoietic and lymphoid	KMS20	11.4
Haematopoietic and lymphoid	KMS21BM	11.9
Haematopoietic and lymphoid	KMS26	12.2
Haematopoietic and lymphoid	KMS27	11.9
Haematopoietic and lymphoid	KMS28BM	12.3
Haematopoietic and lymphoid	KMS34	12.1
Haematopoietic and lymphoid	KO52	12.5
Haematopoietic and lymphoid	KOPN8	12.2
Haematopoietic and lymphoid	KU812	12.3
Haematopoietic and lymphoid	KYO1	13
Haematopoietic and lymphoid	L1236	12.1
Haematopoietic and lymphoid	L363	12.2
Haematopoietic and lymphoid	L428	11.6
Haematopoietic and lymphoid	L540	12
Haematopoietic and lymphoid	LAMA84	12.7
Haematopoietic and lymphoid	LOUCY	12.9
Haematopoietic and lymphoid	LP1	12.7
Haematopoietic and lymphoid	M07E	13.1
Haematopoietic and lymphoid	MC116	11.8
Haematopoietic and lymphoid	ME1	12.7
Haematopoietic and lymphoid	MEC1	12.2
Haematopoietic and lymphoid	MEC2	11.3
Haematopoietic and lymphoid	MEG01	11.5
Haematopoietic and lymphoid	MHHCALL2	12.2
Haematopoietic and lymphoid	MHHCALL3	12.4
Haematopoietic and lymphoid	MHHCALL4	12.1
Haematopoietic and lymphoid	MINO	11.9
Haematopoietic and lymphoid	MJ	12.1
Haematopoietic and lymphoid	MM1S	12.2
Haematopoietic and lymphoid	MOLM13	12.7
Haematopoietic and lymphoid	MOLM16	12.9
Haematopoietic and lymphoid	MOLM6	13.5
Haematopoietic and lymphoid	MOLP2	11.7
Haematopoietic and lymphoid	MOLP8	11.5
Haematopoietic and lymphoid	MOLT13	12.6
Haematopoietic and lymphoid	MOLT16	12.8
Haematopoietic and lymphoid	MOLT4	12.3
Haematopoietic and lymphoid	MONOMAC1	13.1
Haematopoietic and lymphoid	MONOMAC6	12.6
Haematopoietic and lymphoid	MOTN1	12.2
Haematopoietic and lymphoid	MUTZ5	12.3
Haematopoietic and lymphoid	MV411	12.3
Haematopoietic and lymphoid	NALM19	12.5
Haematopoietic and lymphoid	NALM1	12.4
Haematopoietic and lymphoid	NALM6	12
Haematopoietic and lymphoid	NAMALWA	12
Haematopoietic and lymphoid	NB4	12.6
Haematopoietic and lymphoid	NCIH929	11.4
Haematopoietic and lymphoid	NCO2	12.5
Haematopoietic and lymphoid	NOMO1	13.7
Haematopoietic and lymphoid	NUDHL1	12
Haematopoietic and lymphoid	NUDUL1	12.3
Haematopoietic and lymphoid	OCIAML2	13.2
Haematopoietic and lymphoid	OCIAML3	12.8
Haematopoietic and lymphoid	OCIAML5	13.1
Haematopoietic and lymphoid	OCILY10	12.3
Haematopoietic and lymphoid	OCILY19	12.5
Haematopoietic and lymphoid	OCILY3	11.4
Haematopoietic and lymphoid	OCIM1	12.6
Haematopoietic and lymphoid	OPM2	12.4
Haematopoietic and lymphoid	P12ICHIKAWA	11.6
Haematopoietic and lymphoid	P31FUJ	12.9
Haematopoietic and lymphoid	P3HR1	12.3
Haematopoietic and lymphoid	PCM6	12.3
Haematopoietic and lymphoid	PEER	12.3
Haematopoietic and lymphoid	PF382	12.8
Haematopoietic and lymphoid	PFEIFFER	12
Haematopoietic and lymphoid	PL21	13.1
Haematopoietic and lymphoid	RAJI	12
Haematopoietic and lymphoid	RCHACV	12.2
Haematopoietic and lymphoid	REC1	12.2
Haematopoietic and lymphoid	REH	12.3
Haematopoietic and lymphoid	RI1	11.7
Haematopoietic and lymphoid	RL	12.2
Haematopoietic and lymphoid	RPMI8226	11.7
Haematopoietic and lymphoid	RPMI8402	12.2
Haematopoietic and lymphoid	RS411	12.3
Haematopoietic and lymphoid	SEM	12.6
Haematopoietic and lymphoid	SET2	12.2
Haematopoietic and lymphoid	SIGM5	13.6
Haematopoietic and lymphoid	SKM1	13.1
Haematopoietic and lymphoid	SKMM2	12
Haematopoietic and lymphoid	SR786	12.2
Haematopoietic and lymphoid	ST486	12.4
Haematopoietic and lymphoid	SUDHL10	12.2
Haematopoietic and lymphoid	SUDHL1	11
Haematopoietic and lymphoid	SUDHL4	12.4
Haematopoietic and lymphoid	SUDHL5	11.8
Haematopoietic and lymphoid	SUDHL6	12
Haematopoietic and lymphoid	SUDHL8	11.6
Haematopoietic and lymphoid	SUPB15	12.3
Haematopoietic and lymphoid	SUPHD1	12
Haematopoietic and lymphoid	SUPM2	11.8
Haematopoietic and lymphoid	SUPT11	11.6
Haematopoietic and lymphoid	SUPT1	12.4
Haematopoietic and lymphoid	TALL1	12.6
Haematopoietic and lymphoid	TF1	12.2
Haematopoietic and lymphoid	THP1	11.6
Haematopoietic and lymphoid	TO175T	12.3
Haematopoietic and lymphoid	TOLEDO	12.2
Haematopoietic and lymphoid	U266B1	11.8
Haematopoietic and lymphoid	U937	12.8
Haematopoietic and lymphoid	UT7	13.2
Haematopoietic and lymphoid	WSUDLCL2	12.3
Kidney	769P	12.2
Kidney	786O	12.3
Kidney	A498	12.5
Kidney	A704	12.3
Kidney	ACHN	12.8
Kidney	BFTC909	11.5
Kidney	CAKI1	13
Kidney	CAKI2	12.4
Kidney	CAL54	11.8
Kidney	KMRC1	13
Kidney	KMRC20	12.6
Kidney	KMRC2	12.4
Kidney	KMRC3	12.5
Kidney	OSRC2	12.5
Kidney	RCC10RGB	13
Kidney	SNU1272	12.4
Kidney	SNU349	12.1
Kidney	TUHR10TKB	12.6
Kidney	TUHR14TKB	13.1
Kidney	TUHR4TKB	12
Kidney	VMRCRCW	12.1
Kidney	VMRCRCZ	12.5
Large intestine	C2BBE1	12.5
Large intestine	CCK81	12.1
Large intestine	CL11	12
Large intestine	CL14	12.2
Large intestine	CL34	12.4
Large intestine	CL40	12.5
Large intestine	COLO205	12.3
Large intestine	COLO320	11.4
Large intestine	COLO678	12.2
Large intestine	CW2	12.2
Large intestine	DLD1	12.2
Large intestine	GP2D	11.9
Large intestine	HCC56	13
Large intestine	HCT116	11.5
Large intestine	HCT15	11.8
Large intestine	HS675T	12.2
Large intestine	HS698T	12.2
Large intestine	HT115	11.8
Large intestine	HT29	11.7
Large intestine	HT55	12.1
Large intestine	KM12	11.9
Large intestine	LOVO	12.1
Large intestine	LS1034	12.6
Large intestine	LS123	12.4
Large intestine	LS180	12.2
Large intestine	LS411N	12.2
Large intestine	LS513	12.1
Large intestine	MDST8	11.4
Large intestine	NCIH508	12.5
Large intestine	NCIH716	12
Large intestine	NCIH747	12.3
Large intestine	OUMS23	12.4
Large intestine	RCM1	12.2
Large intestine	RKO	12.3
Large intestine	SKCO1	11.2
Large intestine	SNU1040	11.6
Large intestine	SNU1197	12.1
Large intestine	SNU175	11.3
Large intestine	SNU283	12.4
Large intestine	SNU407	12
Large intestine	SNU503	12.1
Large intestine	SNU61	12.5
Large intestine	SNU81	12.5
Large intestine	SNUC1	12
Large intestine	SNUC2A	12.5
Large intestine	SNUC4	12.3
Large intestine	SNUC5	12.2
Large intestine	SW1116	12.5
Large intestine	SW1417	12.1
Large intestine	SW1463	11.9
Large intestine	SW403	12.5
Large intestine	SW480	11.8
Large intestine	SW48	11.7
Large intestine	SW620	12.3
Large intestine	SW837	11.8
Large intestine	SW948	11.6
Large intestine	T84	12.3
Liver	ALEXANDERCELLS	11.7
Liver	C3A	13.4
Liver	HEP3B217	13
Liver	HEPG2	13.2
Liver	HLE	12
Liver	HLF	11.8
Liver	HUH1	12.3
Liver	HUH6	12.5
Liver	HUH7	12.8
Liver	JHH1	13
Liver	JHH2	12.6
Liver	JHH4	11.6
Liver	JHH5	12.3
Liver	JHH6	12.9
Liver	JHH7	13.1
Liver	LI7	12.3
Liver	PLCPRF5	11.4
Liver	SKHEP1	11.9
Liver	SNU182	11.9
Liver	SNU387	12
Liver	SNU398	12
Liver	SNU423	12.4
Liver	SNU449	11.9
Liver	SNU475	12.4
Liver	SNU761	12.3
Liver	SNU878	12.4
Liver	SNU886	12.9
Lung	A549	11.8
Lung	ABC1	12
Lung	BEN	11.8
Lung	CAL12T	12.6
Lung	CALU1	11.8
Lung	CALU3	11.7
Lung	CALU6	12.2
Lung	CHAGOK1	11.9
Lung	COLO668	11.4
Lung	COLO699	12.2
Lung	CORL105	12.7
Lung	CORL23	11.7
Lung	CORL24	11.5
Lung	CORL279	10.4
Lung	CORL311	10.7
Lung	CORL47	10.2
Lung	CORL51	11.4
Lung	CORL88	10.3
Lung	CORL95	11.1
Lung	CPCN	11.5
Lung	DMS114	12.2
Lung	DMS153	11.1
Lung	DMS273	11.4
Lung	DMS454	11.5
Lung	DMS53	12
Lung	DMS79	10.2
Lung	DV90	11.7
Lung	EBC1	12.6
Lung	EPLC272H	12.4
Lung	HARA	12.1
Lung	HCC1171	12.5
Lung	HCC1195	11.8
Lung	HCC15	12.2
Lung	HCC2279	12.2
Lung	HCC2935	12.2
Lung	HCC33	10.8
Lung	HCC366	12.2
Lung	HCC4006	12.7
Lung	HCC44	11.6
Lung	HCC78	12.4
Lung	HCC827	12.1
Lung	HCC95	12
Lung	HLC1	11.7
Lung	HLFA	12.2
Lung	HS229T	12.4
Lung	HS618T	12.5
Lung	IALM	12
Lung	KNS62	12.2
Lung	LC1F	11.7
Lung	LC1SQSF	11.8
Lung	LCLC103H	12.3
Lung	LCLC97TM1	12
Lung	LK2	11.4
Lung	LOUNH91	12
Lung	LU65	12.3
Lung	LU99	12.4
Lung	LUDLU1	12.2
Lung	LXF289	12.2
Lung	MORCPR	11.5
Lung	NCIH1048	12.1
Lung	NCIH1092	10.8
Lung	NCIH1105	9.5
Lung	NCIH1155	11.8
Lung	NCIH1184	11
Lung	NCIH1299	11.4
Lung	NCIH1339	11.3
Lung	NCIH1341	11.5
Lung	NCIH1355	10.9
Lung	NCIH1373	12.4
Lung	NCIH1385	11.8
Lung	NCIH1395	11.8
Lung	NCIH1435	11.8
Lung	NCIH1436	10.6
Lung	NCIH1437	12
Lung	NCIH146	10.9
Lung	NCIH1563	12.3
Lung	NCIH1568	11.9
Lung	NCIH1573	11.1
Lung	NCIH1581	11.8
Lung	NCIH1618	11.7
Lung	NCIH1623	12.2
Lung	NCIH1648	11.3
Lung	NCIH1650	11.4
Lung	NCIH1651	11.6
Lung	NCIH1666	12.7
Lung	NCIH1693	11.9
Lung	NCIH1694	11.6
Lung	NCIH1703	12
Lung	NCIH1734	12.2
Lung	NCIH1755	12.2
Lung	NCIH1781	12.2
Lung	NCIH1792	11.3
Lung	NCIH1793	12.1
Lung	NCIH1836	10.8
Lung	NCIH1838	11.9
Lung	NCIH1869	12
Lung	NCIH1876	11.7
Lung	NCIH1915	12.8
Lung	NCIH1930	9.6
Lung	NCIH1944	11.9
Lung	NCIH1963	10.5
Lung	NCIH196	11.4
Lung	NCIH1975	12.3
Lung	NCIH2009	12.2
Lung	NCIH2023	11.9
Lung	NCIH2029	11.4
Lung	NCIH2030	11.3
Lung	NCIH2066	11.6
Lung	NCIH2081	10.7
Lung	NCIH2085	11.7
Lung	NCIH2087	11.7
Lung	NCIH209	11.5
Lung	NCIH2106	11.5
Lung	NCIH2110	12.2
Lung	NCIH211	11.4
Lung	NCIH2122	12.1
Lung	NCIH2126	11.5
Lung	NCIH2141	11.1
Lung	NCIH2170	11.6
Lung	NCIH2171	11.2
Lung	NCIH2172	11.6
Lung	NCIH2196	10.7
Lung	NCIH2227	9.8
Lung	NCIH2228	12
Lung	NCIH226	13
Lung	NCIH2286	10.9
Lung	NCIH2291	12.2
Lung	NCIH2342	12.4
Lung	NCIH2347	12.5
Lung	NCIH23	11.1
Lung	NCIH2405	12
Lung	NCIH2444	11.4
Lung	NCIH292	12.2
Lung	NCIH322	11.7
Lung	NCIH3255	11.8
Lung	NCIH358	10.9
Lung	NCIH441	11.7
Lung	NCIH446	10.5
Lung	NCIH460	11.5
Lung	NCIH510	10.8
Lung	NCIH520	11.3
Lung	NCIH522	8.5
Lung	NCIH524	11
Lung	NCIH526	11
Lung	NCIH596	11.6
Lung	NCIH647	12.1
Lung	NCIH650	10.5
Lung	NCIH661	11.2
Lung	NCIH69	10.9
Lung	NCIH727	11.5
Lung	NCIH810	11.8
Lung	NCIH82	11
Lung	NCIH838	12
Lung	NCIH841	11.2
Lung	NCIH854	12.1
Lung	NCIH889	10.8
Lung	PC14	12.6
Lung	RERFLCAD1	12.1
Lung	RERFLCAD2	12
Lung	RERFLCAI	11.7
Lung	RERFLCKJ	12.1
Lung	RERFLCMS	11.7
Lung	RERFLCSQ1	12.3
Lung	SBC5	11.5
Lung	SCLC21H	11.9
Lung	SHP77	10.2
Lung	SKLU1	11.1
Lung	SKMES1	11.5
Lung	SQ1	11.7
Lung	SW1271	11.9
Lung	SW1573	12.1
Lung	SW900	12.2
Lung	VMRCLCD	11.7
Lung	VMRCLCP	12.9
Oesophagus	COLO680N	11.7
Oesophagus	ECGI10	11.3
Oesophagus	KYSE140	11.7
Oesophagus	KYSE150	12
Oesophagus	KYSE180	11.8
Oesophagus	KYSE270	12.2
Oesophagus	KYSE30	12.1
Oesophagus	KYSE410	10.9
Oesophagus	KYSE450	12
Oesophagus	KYSE510	11.6
Oesophagus	KYSE520	12
Oesophagus	KYSE70	12.2
Oesophagus	OE19	12
Oesophagus	OE33	12.5
Oesophagus	TE10	11.8
Oesophagus	TE11	12
Oesophagus	TE14	12.5
Oesophagus	TE15	12.2
Oesophagus	TE1	13
Oesophagus	TE4	12.2
Oesophagus	TE5	12.4
Oesophagus	TE6	11.3
Oesophagus	TE8	12.5
Oesophagus	TE9	12.7
Oesophagus	TT	12.6
Ovary	59M	12.9
Ovary	A2780	11.4
Ovary	CAOV3	12.3
Ovary	CAOV4	11.9
Ovary	COLO704	11.3
Ovary	COV318	11.8
Ovary	COV362	12.4
Ovary	COV434	11.5
Ovary	COV504	12.4
Ovary	COV644	12
Ovary	EFO21	11.8
Ovary	EFO27	12
Ovary	ES2	12.1
Ovary	FUOV1	12.5
Ovary	HEYA8	12.3
Ovary	HS571T	12.4
Ovary	IGROV1	11.5
Ovary	JHOC5	12.5
Ovary	JHOM1	13
Ovary	JHOM2B	12.2
Ovary	JHOS2	12.3
Ovary	JHOS4	12.2
Ovary	KURAMOCHI	11.5
Ovary	MCAS	12
Ovary	NIHOVCAR3	12.4
Ovary	OAW28	11.9
Ovary	OAW42	12
Ovary	OC314	12.8
Ovary	OC316	12.7
Ovary	ONCODG1	12.4
Ovary	OV56	11.5
Ovary	OV7	12
Ovary	OV90	12.5
Ovary	OVCAR4	13
Ovary	OVCAR8	12.5
Ovary	OVISE	12.5
Ovary	OVK18	12.5
Ovary	OVKATE	12.3
Ovary	OVMANA	11.8
Ovary	OVSAHO	12.5
Ovary	OVTOKO	12.4
Ovary	RMGI	11.3
Ovary	RMUGS	12.1
Ovary	SKOV3	13.2
Ovary	SNU119	12.2
Ovary	SNU840	12.6
Ovary	SNU8	12.3
Ovary	TOV112D	11.6
Ovary	TOV21G	12.4
Ovary	TYKNU	11.7
Pancreas	ASPC1	12.2
Pancreas	BXPC3	12.2
Pancreas	CAPAN1	12.2
Pancreas	CAPAN2	11.9
Pancreas	CFPAC1	11.9
Pancreas	DANG	12.4
Pancreas	HPAC	12.3
Pancreas	HPAFII	12.2
Pancreas	HS766T	12.6
Pancreas	HUPT3	11
Pancreas	HUPT4	12.1
Pancreas	KCIMOH1	12.3
Pancreas	KLM1	11.6
Pancreas	KP2	11.7
Pancreas	KP3	11.9
Pancreas	KP4	11.9
Pancreas	L33	12
Pancreas	MIAPACA2	11.6
Pancreas	PANC0203	12
Pancreas	PANC0213	11.9
Pancreas	PANC0327	12.2
Pancreas	PANC0403	12.3
Pancreas	PANC0504	12.4
Pancreas	PANC0813	12
Pancreas	PANC1005	11.5
Pancreas	PANC1	12.5
Pancreas	PATU8902	12.1
Pancreas	PATU8988S	12.6
Pancreas	PATU8988T	11.9
Pancreas	PK1	12.5
Pancreas	PK45H	12.7
Pancreas	PK59	12.1
Pancreas	PL45	11.9
Pancreas	PSN1	11.5
Pancreas	QGP1	11.8
Pancreas	SNU213	12.4
Pancreas	SNU324	12.5
Pancreas	SNU410	12.4
Pancreas	SU8686	11.3
Pancreas	SUIT2	11.7
Pancreas	SW1990	12.2
Pancreas	T3M4	12.1
Pancreas	TCCPAN2	12.5
Pancreas	YAPC	12.5
Pleura	ACCMESO1	11.9
Pleura	DM3	12.4
Pleura	ISTMES1	11.8
Pleura	ISTMES2	12.7
Pleura	JL1	11.4
Pleura	MPP89	12.2
Pleura	MSTO211H	11.9
Pleura	NCIH2052	12.5
Pleura	NCIH2452	12.7
Pleura	NCIH28	12.7
Prostate	22RV1	12.3
Prostate	DU145	12.3
Prostate	LNCAPCLONEFGC	12.2
Prostate	MDAPCA2B	12.7
Prostate	NCIH660	12
Prostate	PC3	11.1
Prostate	VCAP	11.6
Salivary gland	A253	12.2
Salivary gland	YD15	12.4
Skin	A101D	12.2
Skin	A2058	11.6
Skin	A375	11.6
Skin	C32	11.5
Skin	CHL1	11.2
Skin	CJM	12.2
Skin	COLO679	12
Skin	COLO741	11.8
Skin	COLO783	11.5
Skin	COLO792	12.2
Skin	COLO800	11.8
Skin	COLO818	11.8
Skin	COLO829	12
Skin	COLO849	12.2
Skin	G361	11.4
Skin	GRM	11.4
Skin	HMCB	10.9
Skin	HS294T	11.7
Skin	HS600T	12.6
Skin	HS688AT	12.6
Skin	HS695T	10.9
Skin	HS839T	12.5
Skin	HS852T	12.5
Skin	HS895T	12.6
Skin	HS934T	12.2
Skin	HS936T	12.6
Skin	HS939T	11.5
Skin	HS940T	12.4
Skin	HS944T	11.6
Skin	HT144	11.8
Skin	IGR1	11.6
Skin	IGR37	12
Skin	IGR39	12.5
Skin	IPC298	12
Skin	K029AX	11.9
Skin	LOXIMVI	11.7
Skin	MALME3M	11.6
Skin	MDAMB435S	12
Skin	MELHO	11.5
Skin	MELJUSO	12
Skin	MEWO	12.3
Skin	RPMI7951	12
Skin	RVH421	11.9
Skin	SH4	11.8
Skin	SKMEL1	12
Skin	SKMEL24	11.3
Skin	SKMEL28	11.9
Skin	SKMEL2	11.8
Skin	SKMEL30	12.4
Skin	SKMEL31	11.4
Skin	SKMEL3	11.3
Skin	SKMEL5	11.6
Skin	UACC257	11.4
Skin	UACC62	11.8
Skin	WM115	11.4
Skin	WM1799	11.9
Skin	WM2664	11.8
Skin	WM793	12.3
Skin	WM88	11.8
Skin	WM983B	11.6
Small intestine	HUTU80	11.8
Soft tissue	A204	11.6
Soft tissue	G401	11.3
Soft tissue	G402	11.7
Soft tissue	GCT	12.1
Soft tissue	HS729	12.2
Soft tissue	HT1080	12.7
Soft tissue	KYM1	11.4
Soft tissue	MESSA	11.6
Soft tissue	RD	12
Soft tissue	RH30	11.7
Soft tissue	RH41	11.1
Soft tissue	RKN	12.1
Soft tissue	S117	12.5
Soft tissue	SJRH30	10.6
Soft tissue	SKLMS1	12.3
Soft tissue	SKUT1	11.7
Soft tissue	TE125T	12.2
Soft tissue	TE159T	12.7
Soft tissue	TE441T	12.2
Soft tissue	TE617T	11.6
Stomach	2313287	12.1
Stomach	AGS	12
Stomach	AZ521	11.6
Stomach	ECC10	11.5
Stomach	ECC12	12
Stomach	FU97	12.6
Stomach	GCIY	12
Stomach	GSS	12
Stomach	GSU	12.5
Stomach	HGC27	12.2
Stomach	HS746T	12
Stomach	HUG1N	12.7
Stomach	IM95	11.9
Stomach	KATOIII	11.7
Stomach	KE39	10.9
Stomach	LMSU	12.6
Stomach	MKN1	11.6
Stomach	MKN45	12.2
Stomach	MKN74	12.9
Stomach	MKN7	12.3
Stomach	NCCSTCK140	11.3
Stomach	NCIN87	12.5
Stomach	NUGC2	12.4
Stomach	NUGC3	11.9
Stomach	NUGC4	12.6
Stomach	OCUM1	12.2
Stomach	RERFGC1B	12.5
Stomach	SH10TC	11.8
Stomach	SNU16	11.8
Stomach	SNU1	11.8
Stomach	SNU216	11.7
Stomach	SNU520	13.1
Stomach	SNU5	12
Stomach	SNU601	12
Stomach	SNU620	12.1
Stomach	SNU668	12.4
Stomach	SNU719	12.3
Stomach	TGBC11TKB	12.6
Thyroid	8305C	11.6
Thyroid	8505C	12
Thyroid	BCPAP	12.6
Thyroid	BHT101	12.1
Thyroid	CAL62	12.2
Thyroid	CGTHW1	12.1
Thyroid	FTC133	13
Thyroid	FTC238	11.6
Thyroid	ML1	13.1
Thyroid	SW579	11.9
Thyroid	TT2609C02	12.3
Thyroid	TT	12.4
Upper aerodigestive tract	BHY	12.5
Upper aerodigestive tract	BICR16	11.5
Upper aerodigestive tract	BICR18	11.9
Upper aerodigestive tract	BICR22	12.9
Upper aerodigestive tract	BICR31	12.3
Upper aerodigestive tract	BICR56	12.6
Upper aerodigestive tract	BICR6	12.8
Upper aerodigestive tract	CAL27	12.9
Upper aerodigestive tract	CAL33	12.6
Upper aerodigestive tract	DETROIT562	11.9
Upper aerodigestive tract	FADU	12.2
Upper aerodigestive tract	HS840T	12.4
Upper aerodigestive tract	HSC2	12.2
Upper aerodigestive tract	HSC3	12.6
Upper aerodigestive tract	HSC4	12.8
Upper aerodigestive tract	PECAPJ15	12.2
Upper aerodigestive tract	PECAPJ34CLONEC12	12.5
Upper aerodigestive tract	PECAPJ41CLONED2	12.4
Upper aerodigestive tract	PECAPJ49	12.3
Upper aerodigestive tract	SCC15	12.6
Upper aerodigestive tract	SCC25	12.6
Upper aerodigestive tract	SCC4	12.2
Upper aerodigestive tract	SCC9	12.2
Upper aerodigestive tract	SNU1076	12.1
Upper aerodigestive tract	SNU1214	11.9
Upper aerodigestive tract	SNU46	11.2
Upper aerodigestive tract	SNU899	12.3
Upper aerodigestive tract	YD10B	12.3
Upper aerodigestive tract	YD38	12.3
Upper aerodigestive tract	YD8	12.7
Urinary tract	5637	11.5
Urinary tract	639V	12
Urinary tract	647V	11.8
Urinary tract	BC3C	12.1
Urinary tract	BFTC905	12.6
Urinary tract	CAL29	12.4
Urinary tract	HS172T	12.8
Urinary tract	HT1197	12.4
Urinary tract	HT1376	12.1
Urinary tract	J82	11.9
Urinary tract	JMSU1	12.4
Urinary tract	KMBC2	11.8
Urinary tract	KU1919	11.9
Urinary tract	RT11284	12.2
Urinary tract	RT112	12.2
Urinary tract	RT4	12.4
Urinary tract	SCABER	12.5
Urinary tract	SW1710	13
Urinary tract	SW780	12.2
Urinary tract	T24	12
Urinary tract	TCCSUP	11.9
Urinary tract	UMUC1	11.6
Urinary tract	UMUC3	12
Urinary tract	VMCUB1	12

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	129.8
Adrenal gland	88.2
Appendix	125.3
Bone marrow	117.2
Breast	117.9
Cerebral cortex	97.1
Cervix, uterine	127.9
Colon	109.8
Duodenum	253.9
Endometrium	115
Epididymis	89.4
Esophagus	120.3
Fallopian tube	100.3
Gallbladder	136.9
Heart muscle	110
Kidney	165.1
Liver	189.4
Lung	158.9
Lymph node	114.6
Ovary	79.3
Pancreas	13.3
Parathyroid gland	137.4
Placenta	184.5
Prostate	205.6
Rectum	127.4
Salivary gland	32.7
Seminal vesicle	108
Skeletal muscle	56.3
Skin	82.8
Small intestine	170.5
Smooth muscle	139.7
Spleen	205.3
Stomach	83.9
Testis	80.1
Thyroid gland	142.7
Tonsil	140.3
Urinary bladder	108.2

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
11561770	underexpression; Loss of Expression	HER2-Positive Breast Carcinoma	Of the 41 cases of IDC, focal or complete loss of ARA70 protein expression was observed in 46% of the cases, with 60% of HER2-positive versus 33% of HER2-negative cases showing loss
11161850	Overexpression	Ovarian Carcinoma	In contrast, a high level of ARA70 expression was observed in 17 of the 20 ovarian carcinomas of various histological types.

Summary
Symbol	NCOA4
Name	nuclear receptor coactivator 4
Aliases	ARA70; RFG; ELE1; PTC3; DKFZp762E1112; RET-activating gene ELE1; 70 kDa AR-activator; 70 kDa androgen recept ......
Location	10q11.22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.377	3.96e-15	29.2	53.2	17.6	Neutral
BRCA	Breast invasive carcinoma	1075	0.26	3.98e-18	20.7	64.7	14.7	Neutral
CESC	Cervical and endocervical cancers	292	0.522	8.68e-22	24.3	69.2	6.5	Neutral
COAD	Colon adenocarcinoma	449	0.302	6.23e-11	19.4	75.7	4.9	Neutral
ESCA	Esophageal carcinoma	183	0.589	1.88e-18	24.6	53.6	21.9	Neutral
GBM	Glioblastoma multiforme	147	0.593	2.45e-15	90.5	9.5	0	Loss
HNSC	Head and Neck squamous cell carcinoma	514	0.352	1.83e-16	23.9	65.8	10.3	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.221	3.13e-07	15.4	82.3	2.3	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.155	0.0085	6.6	91	2.4	Neutral
LAML	Acute Myeloid Leukemia	166	0.121	0.121	1.2	97	1.8	Neutral
LGG	Brain Lower Grade Glioma	513	0.609	1.77e-53	18.3	79.5	2.1	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.333	6.93e-11	17.9	70.1	12.1	Neutral
LUAD	Lung adenocarcinoma	512	0.344	1.11e-15	23	58	18.9	Neutral
LUSC	Lung squamous cell carcinoma	498	0.505	1.35e-33	43.8	42.2	14.1	Loss
OV	Ovarian serous cystadenocarcinoma	300	0.529	4.96e-23	27.3	49	23.7	Neutral
PAAD	Pancreatic adenocarcinoma	177	0.313	2.28e-05	15.8	77.4	6.8	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.2	0.0108	0.6	93.8	5.6	Neutral
PRAD	Prostate adenocarcinoma	491	0.182	4.75e-05	12.2	84.5	3.3	Neutral
READ	Rectum adenocarcinoma	164	0.181	0.0205	19.5	76.2	4.3	Neutral
SARC	Sarcoma	255	0.45	3.81e-14	47.5	46.3	6.3	Loss
SKCM	Skin Cutaneous Melanoma	367	0.464	5.28e-21	59.1	39.2	1.6	Loss
STAD	Stomach adenocarcinoma	413	0.437	1.1e-20	14.8	67.1	18.2	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.268	0.000927	53.3	42	4.7	Loss
THCA	Thyroid carcinoma	497	0.11	0.0144	2.2	97.4	0.4	Neutral
THYM	Thymoma	119	0.387	1.35e-05	0.8	96.6	2.5	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.309	2.45e-13	8.6	70.2	21.2	Neutral

Summary
Symbol	NCOA4
Name	nuclear receptor coactivator 4
Aliases	ARA70; RFG; ELE1; PTC3; DKFZp762E1112; RET-activating gene ELE1; 70 kDa AR-activator; 70 kDa androgen recept ......
Location	10q11.22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.253	1.44e-07	17	408	0	0.014	NS/NA
BRCA	Breast invasive carcinoma	-0.23	8.41e-12	83	785	0.052	0.564	NS/NA
CESC	Cervical and endocervical cancers	-0.22	9.72e-05	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.387	1.37e-12	19	297	0.065	0.0881	NS/NA
ESCA	Esophageal carcinoma	-0.251	0.000425	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.513	1.66e-05	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.179	2.79e-05	20	522	0.442	1.08e-12	Increased
KIRC	Kidney renal clear cell carcinoma	-0.176	0.00111	24	319	0.018	6.96e-05	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.307	7.54e-08	23	275	0.005	0.000165	NS/NA
LAML	Acute Myeloid Leukemia	-0.429	7.48e-09	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.236	4.28e-08	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.35	2.98e-13	41	373	-0.004	0.465	NS/NA
LUAD	Lung adenocarcinoma	-0.265	4.49e-09	21	456	0.142	2.37e-09	NS/NA
LUSC	Lung squamous cell carcinoma	-0.33	6.47e-11	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.833	0.00827	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.228	0.00195	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.146	0.0462	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.237	3.42e-08	35	498	-0.054	5.07e-12	NS/NA
READ	Rectum adenocarcinoma	-0.363	0.000209	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.299	8.56e-07	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.268	3.71e-09	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.174	0.000761	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.221	0.0057	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.124	0.00327	50	509	-0.002	0.00287	NS/NA
THYM	Thymoma	-0.196	0.0303	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.224	1.14e-06	34	431	0.003	0.00278	NS/NA

Summary
Symbol	NCOA4
Name	nuclear receptor coactivator 4
Aliases	ARA70; RFG; ELE1; PTC3; DKFZp762E1112; RET-activating gene ELE1; 70 kDa AR-activator; 70 kDa androgen recept ......
Location	10q11.22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	2	Medium
Appendix	1	Low
Breast	1	Low
Bronchus	1	Low
Cerebellum	1	Low
Cerebral cortex	1	Low
Cervix, uterine	0	Not detected
Colon	1	Low
Duodenum	2	Medium
Endometrium	1	Low
Epididymis	0	Not detected
Esophagus	1	Low
Fallopian tube	0	Not detected
Gallbladder	1	Low
Heart muscle	1	Low
Hippocampus	0	Not detected
Kidney	2	Medium
Liver	2	Medium
Lung	3	High
Lymph node	0	Not detected
Nasopharynx	0	Not detected
Oral mucosa	0	Not detected
Ovary	3	High
Pancreas	2	Medium
Parathyroid gland	1	Low
Placenta	1	Low
Prostate	2	Medium
Rectum	1	Low
Salivary gland	1	Low
Seminal vesicle	1	Low
Skeletal muscle	1	Low
Skin	0	Not detected
Small intestine	1	Low
Smooth muscle	0	Not detected
Soft tissue	0	Not detected
Spleen	2	Medium
Stomach	1	Low
Testis	1	Low
Thyroid gland	1	Low
Tonsil	2	Medium
Urinary bladder	1	Low
Vagina	0	Not detected

Summary
Symbol	NCOA4
Name	nuclear receptor coactivator 4
Aliases	ARA70; RFG; ELE1; PTC3; DKFZp762E1112; RET-activating gene ELE1; 70 kDa AR-activator; 70 kDa androgen recept ......
Location	10q11.22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.673	NS	24476821
BRCA	Breast invasive carcinoma	521	7.27e-09	Significant	23000897
COAD	Colon adenocarcinoma	149	0.000508	Significant	22810696
GBM	Glioblastoma multiforme	157	1e-06	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	7.23e-06	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.00793	Significant	26536169
LGG	Brain Lower Grade Glioma	513	3.06e-23	Significant	26824661
LUAD	Lung adenocarcinoma	230	0.514	NS	25079552
LUSC	Lung squamous cell carcinoma	178	4.84e-06	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.212	NS	21720365
PRAD	Prostate adenocarcinoma	333	5.76e-06	Significant	26544944
READ	Rectum adenocarcinoma	67	0.132	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	3.32e-05	Significant	26091043
STAD	Stomach adenocarcinoma	277	0.0258	Significant	25079317
THCA	Thyroid carcinoma	391	0.491	NS	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.00704	Significant	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	0.969	0.878	NS
BRCA	Breast invasive carcinoma	1079	1.325	0.24	NS
CESC	Cervical and endocervical cancers	291	0.969	0.926	NS
COAD	Colon adenocarcinoma	439	0.583	0.0857	NS
ESCA	Esophageal carcinoma	184	0.903	0.745	NS
GBM	Glioblastoma multiforme	158	0.486	0.00657	Longer
HNSC	Head and Neck squamous cell carcinoma	518	0.824	0.333	NS
KIRC	Kidney renal clear cell carcinoma	531	0.316	3.8e-09	Longer
KIRP	Kidney renal papillary cell carcinoma	287	0.597	0.254	NS
LAML	Acute Myeloid Leukemia	149	0.612	0.075	NS
LGG	Brain Lower Grade Glioma	511	0.301	3.41e-07	Longer
LIHC	Liver hepatocellular carcinoma	365	0.682	0.122	NS
LUAD	Lung adenocarcinoma	502	0.729	0.132	NS
LUSC	Lung squamous cell carcinoma	494	0.895	0.565	NS
OV	Ovarian serous cystadenocarcinoma	303	1.07	0.741	NS
PAAD	Pancreatic adenocarcinoma	177	1.72	0.0629	NS
PCPG	Pheochromocytoma and Paraganglioma	179	543370407.829	0.0336	Shorter
PRAD	Prostate adenocarcinoma	497	4170531418.114	0.157	NS
READ	Rectum adenocarcinoma	159	1.35	0.589	NS
SARC	Sarcoma	259	0.472	0.0119	Longer
SKCM	Skin Cutaneous Melanoma	459	0.809	0.26	NS
STAD	Stomach adenocarcinoma	388	0.936	0.771	NS
TGCT	Testicular Germ Cell Tumors	134	1373087276.146	0.0708	NS
THCA	Thyroid carcinoma	500	1.497	0.529	NS
THYM	Thymoma	119	0.708	0.681	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	0.852	0.607	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	-0.05	0.315	NS
BRCA	Breast invasive carcinoma	1071	-0.006	0.851	NS
CESC	Cervical and endocervical cancers	167	-0.087	0.263	NS
COAD	Colon adenocarcinoma	445	-0.12	0.0116	Lower
ESCA	Esophageal carcinoma	162	-0.021	0.793	NS
HNSC	Head and Neck squamous cell carcinoma	448	-0.13	0.00594	Lower
KIRC	Kidney renal clear cell carcinoma	531	-0.2	3.39e-06	Lower
KIRP	Kidney renal papillary cell carcinoma	260	-0.01	0.876	NS
LIHC	Liver hepatocellular carcinoma	347	-0.008	0.888	NS
LUAD	Lung adenocarcinoma	507	0.047	0.286	NS
LUSC	Lung squamous cell carcinoma	497	0.011	0.81	NS
OV	Ovarian serous cystadenocarcinoma	302	0.164	0.0043	Higher
PAAD	Pancreatic adenocarcinoma	176	0.077	0.307	NS
READ	Rectum adenocarcinoma	156	-0.042	0.6	NS
SKCM	Skin Cutaneous Melanoma	410	-0.044	0.371	NS
STAD	Stomach adenocarcinoma	392	0.044	0.38	NS
TGCT	Testicular Germ Cell Tumors	81	0.201	0.0714	NS
THCA	Thyroid carcinoma	499	-0.022	0.627	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	-0.034	0.449	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	-0.146	0.0161	Lower
HNSC	Head and Neck squamous cell carcinoma	498	-0.04	0.374	NS
KIRC	Kidney renal clear cell carcinoma	525	-0.158	0.000289	Lower
LGG	Brain Lower Grade Glioma	514	-0.142	0.00125	Lower
LIHC	Liver hepatocellular carcinoma	366	-0.111	0.0343	Lower
OV	Ovarian serous cystadenocarcinoma	296	-0.018	0.758	NS
PAAD	Pancreatic adenocarcinoma	176	-0.022	0.768	NS
STAD	Stomach adenocarcinoma	406	0.042	0.403	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	-0.026	0.542	NS

Summary
Symbol	NCOA4
Name	nuclear receptor coactivator 4
Aliases	ARA70; RFG; ELE1; PTC3; DKFZp762E1112; RET-activating gene ELE1; 70 kDa AR-activator; 70 kDa androgen recept ......
Location	10q11.22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	NCOA4
Name	nuclear receptor coactivator 4
Aliases	ARA70; RFG; ELE1; PTC3; DKFZp762E1112; RET-activating gene ELE1; 70 kDa AR-activator; 70 kDa androgen recept ......
Location	10q11.22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for NCOA4.

Summary
Symbol	NCOA4
Name	nuclear receptor coactivator 4
Aliases	ARA70; RFG; ELE1; PTC3; DKFZp762E1112; RET-activating gene ELE1; 70 kDa AR-activator; 70 kDa androgen recept ......
Location	10q11.22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
26078337	Colorectal Carcinoma	partner	RET	Fusion	Through comprehensive genomic profiling we prospectively identified 6 RET fusion kinases, including two novel fusions of CCDC6-RET and NCOA4-RET, in metastatic colorectal cancer (CRC) patients.
23327964	Papillary Thyroid Carcinoma	partner	RET	Fusion	BRAF T1799A mutation and RET/PTC3 rearrangement in patients suggests a poorer prognosis than the negative one.
22457234	Papillary Thyroid Carcinoma	partner	RET	Fusion	In total, 46/70 (66%) cases carried a BRAF mutation and/or a RET/PTC rearrangement. A BRAF mutation was detected in 26 tumors, RET/PTC1 in 20 cases, and RET/PTC3 in four cases.
21674964	Papillary Thyroid Carcinoma	partner	RET	Fusion	It was established that induction of both, RET/PTC1 and RET/PTC3 rearrangements was present only in carcinoma samples.
20839015	Papillary Thyroid Carcinoma	partner	RET	Fusion	Several cytoskeletal protein species showed quantitative changes in tumors and lymph node metastases harboring RET/PTC1 or RET/PTC3.
19765726	Papillary Thyroid Carcinoma	partner	RET	Fusion	The primary tumor genotype in 217 patients with papillary thyroid cancer was determined for six common somatic genetic alterations (RET/PTC1, RET/PTC3, and NTRK1 rearrangements, and BRAF V600E, KRAS, and NRAS hotspot mutations) by PCR and direct sequencing, and nested PCR.
16630482	Papillary Thyroid Carcinoma	partner	RET	Fusion	(3) Fourteen PTCs (21.2%) expressed RET/PTC, including five cases expressing RET/PTC1 and nine cases expressing RET/PTC3.
12457448	Papillary Thyroid Carcinoma	partner	RET	Fusion	The prevalence of RET/PTC activation in PTC is high and RET/PTC3 is the only type of activation identified in Hong Kong Chinese and is an important genetic event underlying the development of PTC in the population
11318605	Papillary Thyroid Carcinoma	partner	RET	Fusion	More than 90% of PTC with RET rearrangement exhibit a PTC1 or PTC3 type of rearrangement with an inversion of the H4 or ELE1 gene, respectively, on chromosome 10.
10566678	Papillary Thyroid Carcinoma	partner	RET	Fusion	A strong correlation was observed between the solid-follicular subtype of papillary carcinoma and the RET/PTC3 isoform: 19 of the 24 RET/PTC-positive solid-follicular carcinomas harbored a RET/PTC3 rearrangement, whereas only 5 had a RET/PTC1 rearrangement.