CR2Cancer

Summary
Symbol	NIPBL
Name	NIPBL, cohesin loading factor
Aliases	IDN3; DKFZp434L1319; FLJ11203; FLJ12597; FLJ13354; FLJ13648; Scc2; sister chromatid cohesion 2 homolog (yeas ......
Location	5p13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

[ TOP ]

Domain

PF12765 HEAT repeat associated with sister chromatid cohesion
PF12830 Sister chromatid cohesion C-terminus

Function

Probably plays a structural role in chromatin. Involved in sister chromatid cohesion, possibly by interacting with the cohesin complex (By similarity).

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification erase cofactor	Histone acetylation	#	#	25255084, 18854353

> Gene Ontology [ TOP ]
Biological Process	GO:0000070 mitotic sister chromatid segregation GO:0000819 sister chromatid segregation GO:0001501 skeletal system development GO:0001503 ossification GO:0001654 eye development GO:0001655 urogenital system development GO:0001656 metanephros development GO:0001822 kidney development GO:0003007 heart morphogenesis GO:0003151 outflow tract morphogenesis GO:0006476 protein deacetylation GO:0007059 chromosome segregation GO:0007062 sister chromatid cohesion GO:0007064 mitotic sister chromatid cohesion GO:0007067 mitotic nuclear division GO:0007423 sensory organ development GO:0007507 heart development GO:0007548 sex differentiation GO:0007605 sensory perception of sound GO:0009314 response to radiation GO:0010165 response to X-ray GO:0010171 body morphogenesis GO:0010212 response to ionizing radiation GO:0016570 histone modification GO:0016575 histone deacetylation GO:0019827 stem cell population maintenance GO:0030278 regulation of ossification GO:0030326 embryonic limb morphogenesis GO:0031056 regulation of histone modification GO:0031058 positive regulation of histone modification GO:0031063 regulation of histone deacetylation GO:0031065 positive regulation of histone deacetylation GO:0034086 maintenance of sister chromatid cohesion GO:0034088 maintenance of mitotic sister chromatid cohesion GO:0035107 appendage morphogenesis GO:0035108 limb morphogenesis GO:0035112 genitalia morphogenesis GO:0035113 embryonic appendage morphogenesis GO:0035115 embryonic forelimb morphogenesis GO:0035136 forelimb morphogenesis GO:0035239 tube morphogenesis GO:0035261 external genitalia morphogenesis GO:0035264 multicellular organism growth GO:0035601 protein deacylation GO:0040014 regulation of multicellular organism growth GO:0040018 positive regulation of multicellular organism growth GO:0042303 molting cycle GO:0042471 ear morphogenesis GO:0042633 hair cycle GO:0042634 regulation of hair cycle GO:0043583 ear development GO:0045444 fat cell differentiation GO:0045778 positive regulation of ossification GO:0045927 positive regulation of growth GO:0045995 regulation of embryonic development GO:0048546 digestive tract morphogenesis GO:0048557 embryonic digestive tract morphogenesis GO:0048562 embryonic organ morphogenesis GO:0048565 digestive tract development GO:0048566 embryonic digestive tract development GO:0048568 embryonic organ development GO:0048592 eye morphogenesis GO:0048608 reproductive structure development GO:0048638 regulation of developmental growth GO:0048639 positive regulation of developmental growth GO:0048701 embryonic cranial skeleton morphogenesis GO:0048703 embryonic viscerocranium morphogenesis GO:0048704 embryonic skeletal system morphogenesis GO:0048705 skeletal system morphogenesis GO:0048706 embryonic skeletal system development GO:0048736 appendage development GO:0048806 genitalia development GO:0050890 cognition GO:0050954 sensory perception of mechanical stimulus GO:0055123 digestive system development GO:0060065 uterus development GO:0060173 limb development GO:0060323 head morphogenesis GO:0060324 face development GO:0060325 face morphogenesis GO:0061008 hepaticobiliary system development GO:0061010 gall bladder development GO:0061038 uterus morphogenesis GO:0061458 reproductive system development GO:0071214 cellular response to abiotic stimulus GO:0071478 cellular response to radiation GO:0071479 cellular response to ionizing radiation GO:0071481 cellular response to X-ray GO:0072001 renal system development GO:0090311 regulation of protein deacetylation GO:0090312 positive regulation of protein deacetylation GO:0090596 sensory organ morphogenesis GO:0098727 maintenance of cell number GO:0098732 macromolecule deacylation GO:0098813 nuclear chromosome segregation GO:1902275 regulation of chromatin organization GO:1904888 cranial skeletal system development GO:1905269 positive regulation of chromatin organization
Molecular Function	GO:0003682 chromatin binding GO:0008022 protein C-terminus binding GO:0036033 mediator complex binding GO:0042826 histone deacetylase binding GO:0047485 protein N-terminus binding GO:0070087 chromo shadow domain binding
Cellular Component	GO:0000785 chromatin GO:0032116 SMC loading complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-1640170: Cell Cycle R-HSA-69278: Cell Cycle, Mitotic R-HSA-2470946: Cohesin Loading onto Chromatin R-HSA-68886: M Phase R-HSA-68884: Mitotic Telophase/Cytokinesis

Summary
Symbol	NIPBL
Name	NIPBL, cohesin loading factor
Aliases	IDN3; DKFZp434L1319; FLJ11203; FLJ12597; FLJ13354; FLJ13648; Scc2; sister chromatid cohesion 2 homolog (yeas ......
Location	5p13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM3827997	c.1560T>G	p.G520G	Substitution - coding silent	Breast
COSM5804280	c.2392G>A	p.A798T	Substitution - Missense	Liver
COSM1620271	c.4776+9A>G	p.?	Unknown	Liver
COSM4884551	c.6619A>T	p.M2207L	Substitution - Missense	Upper_aerodigestive_tract
COSM5777477	c.976C>T	p.Q326*	Substitution - Nonsense	Breast
COSM3947480	c.733G>C	p.E245Q	Substitution - Missense	Lung
COSM1067679	c.4223_4224delAC	p.T1409fs*20	Deletion - Frameshift	Endometrium
COSM186813	c.3659C>T	p.A1220V	Substitution - Missense	Large_intestine
COSM1620273	c.5029A>G	p.I1677V	Substitution - Missense	Liver
COSM2687777	c.1235G>A	p.R412H	Substitution - Missense	Pancreas
COSM3947486	c.8068C>T	p.R2690*	Substitution - Nonsense	Lung
COSM382910	c.2838_2839GG>TT	p.L946>?	Complex	Lung
COSM4424792	c.4300G>A	p.A1434T	Substitution - Missense	Oesophagus
COSM4706966	c.449G>A	p.S150N	Substitution - Missense	Large_intestine
COSM4641231	c.7018C>T	p.Q2340*	Substitution - Nonsense	Large_intestine
COSM162915	c.7744C>T	p.R2582*	Substitution - Nonsense	Breast
COSM5568911	c.253A>G	p.S85G	Substitution - Missense	Prostate
COSM1067687	c.5018G>A	p.R1673H	Substitution - Missense	Endometrium
COSM3373875	c.3665G>A	p.G1222D	Substitution - Missense	Thyroid
COSM3366059	c.7008C>T	p.N2336N	Substitution - coding silent	Kidney
COSM387547	c.229A>T	p.I77L	Substitution - Missense	Lung
COSM1437262	c.1801delA	p.K603fs*11	Deletion - Frameshift	Large_intestine
COSM737908	c.3133C>G	p.Q1045E	Substitution - Missense	Lung
COSM737896	c.5641A>G	p.T1881A	Substitution - Missense	Lung
COSM1067651	c.1123G>A	p.D375N	Substitution - Missense	Endometrium
COSM5884224	c.4495C>T	p.Q1499*	Substitution - Nonsense	Breast
COSM1437264	c.1802A>C	p.K601T	Substitution - Missense	Large_intestine
COSM1671595	c.8119G>T	p.V2707F	Substitution - Missense	Prostate
COSM3715066	c.4934A>G	p.E1645G	Substitution - Missense	Upper_aerodigestive_tract
COSM5061072	c.20A>G	p.H7R	Substitution - Missense	Stomach
COSM1067645	c.962G>T	p.R321I	Substitution - Missense	Large_intestine
COSM5346144	c.1663G>A	p.A555T	Substitution - Missense	Liver
COSM1067657	c.1546G>T	p.G516C	Substitution - Missense	Endometrium
COSM4441799	c.6080T>C	p.M2027T	Substitution - Missense	Large_intestine
COSM328564	c.423T>A	p.N141K	Substitution - Missense	Kidney
COSM1067699	c.5567G>T	p.R1856I	Substitution - Missense	Endometrium
COSM328564	c.423T>A	p.N141K	Substitution - Missense	Kidney
COSM4898746	c.8133C>T	p.I2711I	Substitution - coding silent	Skin
COSM1437262	c.1801delA	p.K603fs*11	Deletion - Frameshift	Large_intestine
COSM3975522	c.5375C>A	p.A1792D	Substitution - Missense	Central_nervous_system
COSM3732592	c.3673G>A	p.D1225N	Substitution - Missense	Stomach
COSM6011766	c.1165G>A	p.D389N	Substitution - Missense	Skin
COSM4625548	c.4834T>C	p.Y1612H	Substitution - Missense	Large_intestine
COSM5466446	c.4363G>T	p.E1455*	Substitution - Nonsense	Large_intestine
COSM4849829	c.7318T>A	p.Y2440N	Substitution - Missense	Cervix
COSM5403417	c.5700G>A	p.E1900E	Substitution - coding silent	Skin
COSM737912	c.2205T>C	p.T735T	Substitution - coding silent	Lung
COSM4797073	c.3834G>A	p.K1278K	Substitution - coding silent	Liver
COSM5803252	c.449G>C	p.S150T	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3615958	c.5557C>T	p.L1853L	Substitution - coding silent	Skin
COSM4648884	c.1254A>G	p.Q418Q	Substitution - coding silent	Large_intestine
COSM1328817	c.8378G>A	p.R2793Q	Substitution - Missense	Ovary
COSM1067683	c.4912T>C	p.L1638L	Substitution - coding silent	Endometrium
COSM737894	c.6590G>T	p.G2197V	Substitution - Missense	Pancreas
COSM1067733	c.7736C>T	p.A2579V	Substitution - Missense	Endometrium
COSM1437258	c.1507delA	p.R505fs*35	Deletion - Frameshift	Large_intestine
COSM3854999	c.431A>G	p.Q144R	Substitution - Missense	Stomach
COSM4706980	c.4263_4264insT	p.V1424fs*6	Insertion - Frameshift	Breast
COSM3855007	c.1656C>T	p.D552D	Substitution - coding silent	Stomach
COSM5726407	c.3419G>A	p.S1140N	Substitution - Missense	Skin
COSM3855037	c.5335C>T	p.R1779*	Substitution - Nonsense	Stomach
COSM4706990	c.6656delT	p.L2220fs*10	Deletion - Frameshift	Large_intestine
COSM5428938	c.2133T>C	p.P711P	Substitution - coding silent	Oesophagus
COSM3827987	c.792G>A	p.M264I	Substitution - Missense	Breast
COSM2687952	c.4930G>A	p.G1644R	Substitution - Missense	Large_intestine
COSM328564	c.423T>A	p.N141K	Substitution - Missense	Kidney
COSM4706968	c.449_450insC	p.S152fs*21	Insertion - Frameshift	Large_intestine
COSM4706972	c.1543delG	p.G516fs*24	Deletion - Frameshift	Large_intestine
COSM4585864	c.2772C>T	p.N924N	Substitution - coding silent	Bone
COSM5900018	c.3452C>T	p.P1151L	Substitution - Missense	Skin
COSM381029	c.3472G>C	p.D1158H	Substitution - Missense	Lung
COSM4464631	c.1343C>T	p.P448L	Substitution - Missense	Skin
COSM1239604	c.6891A>G	p.V2297V	Substitution - coding silent	Oesophagus
COSM5498903	c.7244A>G	p.N2415S	Substitution - Missense	Biliary_tract
COSM5715614	c.1978G>T	p.E660*	Substitution - Nonsense	Skin
COSM4628425	c.927T>C	p.D309D	Substitution - coding silent	Large_intestine
COSM2687779	c.1439T>C	p.I480T	Substitution - Missense	Stomach
COSM3855023	c.4542A>C	p.E1514D	Substitution - Missense	Stomach
COSM5506848	c.3137C>G	p.S1046*	Substitution - Nonsense	Biliary_tract
COSM3855047	c.6427T>A	p.S2143T	Substitution - Missense	Stomach
COSM420716	c.6359T>A	p.L2120*	Substitution - Nonsense	Urinary_tract
COSM5403415	c.5099C>T	p.S1700L	Substitution - Missense	Skin
COSM5918710	c.6610C>T	p.P2204S	Substitution - Missense	Skin
COSM4707000	c.8369A>G	p.Q2790R	Substitution - Missense	Large_intestine
COSM3776665	c.57C>T	p.L19L	Substitution - coding silent	Urinary_tract
COSM3722774	c.6742A>G	p.M2248V	Substitution - Missense	Upper_aerodigestive_tract
COSM1067731	c.7603G>A	p.E2535K	Substitution - Missense	Endometrium
COSM283257	c.2500C>T	p.R834*	Substitution - Nonsense	Large_intestine
COSM1181004	c.8320delA	p.I2776fs*3	Deletion - Frameshift	Large_intestine
COSM3828011	c.5328G>A	p.Q1776Q	Substitution - coding silent	Breast
COSM5628673	c.3619G>A	p.E1207K	Substitution - Missense	Oesophagus
COSM3941303	c.4464G>T	p.Q1488H	Substitution - Missense	Oesophagus
COSM366507	c.7113C>A	p.I2371I	Substitution - coding silent	Lung
COSM5715614	c.1978G>T	p.E660*	Substitution - Nonsense	Skin
COSM4752929	c.6356A>G	p.K2119R	Substitution - Missense	Stomach
COSM212400	c.5366G>T	p.R1789L	Substitution - Missense	Breast
COSM3736917	c.2021A>G	p.N674S	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1754256	c.942C>T	p.I314I	Substitution - coding silent	Urinary_tract
COSM4495801	c.460C>T	p.R154W	Substitution - Missense	Skin
COSM3732671	c.4543G>A	p.E1515K	Substitution - Missense	Stomach
COSM1328820	c.3783A>C	p.K1261N	Substitution - Missense	Ovary
COSM176558	c.134G>A	p.R45Q	Substitution - Missense	Large_intestine
COSM5356561	c.5628T>C	p.C1876C	Substitution - coding silent	Large_intestine
COSM4706992	c.6678A>G	p.S2226S	Substitution - coding silent	Large_intestine
COSM420720	c.2598A>G	p.L866L	Substitution - coding silent	Urinary_tract
COSM4450036	c.4240-1G>A	p.?	Unknown	Skin
COSM3855039	c.5455C>T	p.R1819*	Substitution - Nonsense	Stomach
COSM4706974	c.1692delA	p.K566fs*48	Deletion - Frameshift	Large_intestine
COSM5915420	c.65-8C>T	p.?	Unknown	Skin
COSM4706988	c.6386A>G	p.N2129S	Substitution - Missense	Large_intestine
COSM1067719	c.7156G>A	p.E2386K	Substitution - Missense	Endometrium
COSM3736917	c.2021A>G	p.N674S	Substitution - Missense	Skin
COSM5094929	c.6187G>C	p.E2063Q	Substitution - Missense	Thymus
COSM3855031	c.5164A>G	p.N1722D	Substitution - Missense	Stomach
COSM5416103	c.5921T>G	p.L1974R	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4994130	c.5071G>T	p.A1691S	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1181004	c.8320delA	p.I2776fs*3	Deletion - Frameshift	Large_intestine
COSM3736917	c.2021A>G	p.N674S	Substitution - Missense	Soft_tissue
COSM4878526	c.8195G>A	p.S2732N	Substitution - Missense	Prostate
COSM3828007	c.4237C>T	p.Q1413*	Substitution - Nonsense	Breast
COSM5715614	c.1978G>T	p.E660*	Substitution - Nonsense	Skin
COSM1217356	c.5044C>T	p.R1682*	Substitution - Nonsense	Large_intestine
COSM328564	c.423T>A	p.N141K	Substitution - Missense	Kidney
COSM4894362	c.1459G>A	p.E487K	Substitution - Missense	Skin
COSM1620277	c.8131A>G	p.I2711V	Substitution - Missense	Liver
COSM3855049	c.7219C>T	p.R2407*	Substitution - Nonsense	Stomach
COSM4746989	c.2246delA	p.N751fs*43	Deletion - Frameshift	Stomach
COSM4797073	c.3834G>A	p.K1278K	Substitution - coding silent	Liver
COSM3855029	c.5076G>A	p.M1692I	Substitution - Missense	Stomach
COSM1695613	c.1090C>T	p.R364C	Substitution - Missense	Skin
COSM5928703	c.5045G>A	p.R1682Q	Substitution - Missense	Skin
COSM3855001	c.467T>C	p.V156A	Substitution - Missense	Stomach
COSM3736917	c.2021A>G	p.N674S	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5352202	c.5595_5596insA	p.R1867fs*12	Insertion - Frameshift	Kidney
COSM482779	c.6120T>A	p.D2040E	Substitution - Missense	Kidney
COSM3855021	c.4068C>A	p.Y1356*	Substitution - Nonsense	Stomach
COSM4706996	c.7168G>A	p.A2390T	Substitution - Missense	Large_intestine
COSM449594	c.3923C>T	p.A1308V	Substitution - Missense	Large_intestine
COSM1581320	c.185T>G	p.V62G	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1437254	c.71A>G	p.N24S	Substitution - Missense	Large_intestine
COSM116024	c.1045A>G	p.S349G	Substitution - Missense	Ovary
COSM737900	c.4903G>A	p.E1635K	Substitution - Missense	Lung
COSM4706976	c.3121+1G>T	p.?	Unknown	Large_intestine
COSM5006083	c.8327_8328insA	p.A2777fs*6	Insertion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM3855035	c.5314A>T	p.I1772F	Substitution - Missense	Stomach
COSM482771	c.4131C>A	p.T1377T	Substitution - coding silent	Kidney
COSM3855013	c.2550T>C	p.S850S	Substitution - coding silent	Stomach
COSM5756656	c.3518A>C	p.K1173T	Substitution - Missense	Large_intestine
COSM4628427	c.6982A>G	p.T2328A	Substitution - Missense	Large_intestine
COSM2687777	c.1235G>A	p.R412H	Substitution - Missense	Pancreas
COSM4389045	c.6143C>T	p.A2048V	Substitution - Missense	Pancreas
COSM3615934	c.1486C>T	p.Q496*	Substitution - Nonsense	Skin
COSM1754254	c.834A>G	p.V278V	Substitution - coding silent	Urinary_tract
COSM1181004	c.8320delA	p.I2776fs*3	Deletion - Frameshift	Large_intestine
COSM4916593	c.4299T>C	p.C1433C	Substitution - coding silent	Liver
COSM1620273	c.5029A>G	p.I1677V	Substitution - Missense	Liver
COSM592297	c.2521C>T	p.R841*	Substitution - Nonsense	Skin
COSM1437262	c.1801delA	p.K603fs*11	Deletion - Frameshift	Large_intestine
COSM5472106	c.8096C>T	p.A2699V	Substitution - Missense	Large_intestine
COSM5726402	c.1470C>T	p.R490R	Substitution - coding silent	Skin
COSM2687797	c.1693A>G	p.K565E	Substitution - Missense	Upper_aerodigestive_tract
COSM4776268	c.2536T>C	p.L846L	Substitution - coding silent	Soft_tissue
COSM4775972	c.2389C>T	p.R797*	Substitution - Nonsense	Biliary_tract
COSM4141794	c.6840G>A	p.Q2280Q	Substitution - coding silent	Ovary
COSM5734241	c.4264_4265insT	p.V1424fs*6	Insertion - Frameshift	Pancreas
COSM22140	c.7263+1G>A	p.?	Unknown	Large_intestine
COSM1743911	c.457A>T	p.S153C	Substitution - Missense	Biliary_tract
COSM4187654	c.6930_6937delTCAAGGTC	p.Q2311fs*26	Deletion - Frameshift	Kidney
COSM4585866	c.8113G>A	p.V2705I	Substitution - Missense	Bone
COSM1311130	c.8352G>A	p.L2784L	Substitution - coding silent	Urinary_tract
COSM1067667	c.2681G>A	p.R894H	Substitution - Missense	Endometrium
COSM1217360	c.5216G>A	p.S1739N	Substitution - Missense	Large_intestine
COSM5931692	c.8161C>T	p.R2721*	Substitution - Nonsense	Skin
COSM1311128	c.7685+1G>A	p.?	Unknown	Urinary_tract
COSM4141790	c.5709+1G>C	p.?	Unknown	Ovary
COSM482775	c.5354C>G	p.A1785G	Substitution - Missense	Kidney
COSM2688051	c.7473C>T	p.S2491S	Substitution - coding silent	Large_intestine
COSM3674437	c.5286C>A	p.S1762S	Substitution - coding silent	Prostate
COSM3855019	c.3928G>A	p.A1310T	Substitution - Missense	Stomach
COSM5924361	c.3026C>T	p.S1009F	Substitution - Missense	Skin
COSM1471819	c.4906C>G	p.R1636G	Substitution - Missense	Prostate
COSM124751	c.1574C>G	p.S525C	Substitution - Missense	Upper_aerodigestive_tract
COSM391259	c.7685delG	p.S2562fs*19	Deletion - Frameshift	Lung
COSM1067675	c.3862G>A	p.D1288N	Substitution - Missense	Endometrium
COSM2687714	c.3G>A	p.M1I	Substitution - Missense	Oesophagus
COSM1581324	c.8392G>A	p.A2798T	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1620271	c.4776+9A>G	p.?	Unknown	Liver
COSM1437262	c.1801delA	p.K603fs*11	Deletion - Frameshift	Large_intestine
COSM5731417	c.1151A>G	p.N384S	Substitution - Missense	Central_nervous_system
COSM3855043	c.5809-1G>T	p.?	Unknown	Stomach
COSM1259129	c.3007G>C	p.V1003L	Substitution - Missense	Oesophagus
COSM1620269	c.3929C>T	p.A1310V	Substitution - Missense	Liver
COSM5761132	c.4001_4002delAA	p.R1335fs*6	Deletion - Frameshift	Pancreas
COSM1743913	c.7174T>C	p.C2392R	Substitution - Missense	Biliary_tract
COSM737916	c.268G>T	p.G90C	Substitution - Missense	Bone
COSM4768822	c.1772C>G	p.S591C	Substitution - Missense	Biliary_tract
COSM1067739	c.8134G>A	p.A2712T	Substitution - Missense	Endometrium
COSM4775972	c.2389C>T	p.R797*	Substitution - Nonsense	Haematopoietic_and_lymphoid_tissue
COSM1742347	c.4320+4A>G	p.?	Unknown	Urinary_tract
COSM5995790	c.2261G>A	p.R754Q	Substitution - Missense	Prostate
COSM3828009	c.5156G>A	p.R1719Q	Substitution - Missense	Breast
COSM4772425	c.2494C>T	p.R832*	Substitution - Nonsense	Stomach
COSM1496143	c.6659T>A	p.L2220*	Substitution - Nonsense	Kidney
COSM186829	c.5680C>T	p.R1894C	Substitution - Missense	Stomach
COSM3615952	c.4203A>T	p.L1401L	Substitution - coding silent	Skin
COSM4746214	c.5356A>G	p.I1786V	Substitution - Missense	Central_nervous_system
COSM3373873	c.2605A>G	p.K869E	Substitution - Missense	Thyroid
COSM5549289	c.7718C>A	p.A2573E	Substitution - Missense	Prostate
COSM1217354	c.1413G>T	p.L471F	Substitution - Missense	Large_intestine
COSM1754254	c.834A>G	p.V278V	Substitution - coding silent	Urinary_tract
COSM4752911	c.3344G>C	p.W1115S	Substitution - Missense	Stomach
COSM79004	c.2582C>A	p.S861*	Substitution - Nonsense	Ovary
COSM1734393	c.6455G>A	p.R2152Q	Substitution - Missense	Pancreas
COSM5351811	c.6892C>T	p.R2298C	Substitution - Missense	Kidney
COSM1067711	c.6669G>T	p.K2223N	Substitution - Missense	Endometrium
COSM1437262	c.1801delA	p.K603fs*11	Deletion - Frameshift	Large_intestine
COSM4881587	c.529C>G	p.P177A	Substitution - Missense	Upper_aerodigestive_tract
COSM4819890	c.703C>G	p.H235D	Substitution - Missense	Cervix
COSM4480067	c.2384C>T	p.S795L	Substitution - Missense	Skin
COSM3827991	c.1358T>C	p.V453A	Substitution - Missense	Breast
COSM4618516	c.2481G>T	p.R827S	Substitution - Missense	Large_intestine
COSM420718	c.5254G>A	p.D1752N	Substitution - Missense	Urinary_tract
COSM2688096	c.8093C>T	p.A2698V	Substitution - Missense	Large_intestine
COSM5797849	c.4891C>T	p.Q1631*	Substitution - Nonsense	Breast
COSM3661806	c.358+8T>G	p.?	Unknown	Liver
COSM176558	c.134G>A	p.R45Q	Substitution - Missense	Large_intestine
COSM3661806	c.358+8T>G	p.?	Unknown	Liver
COSM3855013	c.2550T>C	p.S850S	Substitution - coding silent	Stomach
COSM1067740	c.8398G>A	p.D2800N	Substitution - Missense	Endometrium
COSM1067665	c.2575G>C	p.D859H	Substitution - Missense	Endometrium
COSM1067663	c.2313A>G	p.P771P	Substitution - coding silent	Endometrium
COSM3919994	c.3433C>T	p.R1145C	Substitution - Missense	Skin
COSM4854669	c.149T>C	p.V50A	Substitution - Missense	Cervix
COSM1259127	c.5972-10_5972-9insT	p.?	Unknown	Oesophagus
COSM2688067	c.7753G>A	p.G2585R	Substitution - Missense	Skin
COSM4485479	c.293C>T	p.A98V	Substitution - Missense	Skin
COSM4387043	c.6947C>T	p.P2316L	Substitution - Missense	Lung
COSM3615936	c.1585G>C	p.G529R	Substitution - Missense	Skin
COSM737894	c.6590G>T	p.G2197V	Substitution - Missense	Lung
COSM1663066	c.1252C>T	p.Q418*	Substitution - Nonsense	Kidney
COSM1757128	c.2228G>A	p.R743H	Substitution - Missense	Urinary_tract
COSM1437262	c.1801delA	p.K603fs*11	Deletion - Frameshift	Stomach
COSM4829874	c.776G>C	p.G259A	Substitution - Missense	Cervix
COSM3733037	c.3227G>A	p.R1076H	Substitution - Missense	Stomach
COSM1159417	c.790A>G	p.M264V	Substitution - Missense	Pancreas
COSM186819	c.4264delT	p.F1423fs*15	Deletion - Frameshift	Oesophagus
COSM3615964	c.8069G>A	p.R2690Q	Substitution - Missense	Skin
COSM482777	c.5575G>T	p.D1859Y	Substitution - Missense	Kidney
COSM1067649	c.1091G>A	p.R364H	Substitution - Missense	Endometrium
COSM1067669	c.3130G>T	p.D1044Y	Substitution - Missense	Endometrium
COSM1437262	c.1801delA	p.K603fs*11	Deletion - Frameshift	Large_intestine
COSM139574	c.1555G>A	p.G519R	Substitution - Missense	Skin
COSM1437274	c.2838delG	p.G948fs*6	Deletion - Frameshift	Large_intestine
COSM737904	c.3510G>A	p.R1170R	Substitution - coding silent	Lung
COSM176558	c.134G>A	p.R45Q	Substitution - Missense	Stomach
COSM3615938	c.1689C>A	p.S563S	Substitution - coding silent	Skin
COSM3661810	c.4040C>T	p.T1347I	Substitution - Missense	Liver
COSM1620269	c.3929C>T	p.A1310V	Substitution - Missense	Liver
COSM1437262	c.1801delA	p.K603fs*11	Deletion - Frameshift	Large_intestine
COSM1067653	c.1263G>A	p.S421S	Substitution - coding silent	Liver
COSM249116	c.1317G>T	p.Q439H	Substitution - Missense	Pancreas
COSM737916	c.268G>T	p.G90C	Substitution - Missense	Lung
COSM1067653	c.1263G>A	p.S421S	Substitution - coding silent	Stomach
COSM1217362	c.922C>T	p.R308*	Substitution - Nonsense	Large_intestine
COSM1620277	c.8131A>G	p.I2711V	Substitution - Missense	Liver
COSM5551960	c.8160T>G	p.D2720E	Substitution - Missense	Prostate
COSM1695617	c.3190C>T	p.P1064S	Substitution - Missense	Skin
COSM5886416	c.3059G>A	p.R1020K	Substitution - Missense	Skin
COSM1634213	c.2955A>G	p.K985K	Substitution - coding silent	Liver
COSM1757126	c.2134G>C	p.E712Q	Substitution - Missense	Urinary_tract
COSM4816612	c.2042C>G	p.T681R	Substitution - Missense	Cervix
COSM4409922	c.3301G>A	p.E1101K	Substitution - Missense	Oesophagus
COSM3661812	c.5450A>G	p.H1817R	Substitution - Missense	Liver
COSM3615928	c.512A>G	p.N171S	Substitution - Missense	Skin
COSM5568898	c.2544C>A	p.S848S	Substitution - coding silent	Prostate
COSM1743915	c.6776C>T	p.A2259V	Substitution - Missense	Biliary_tract
COSM2687952	c.4930G>A	p.G1644R	Substitution - Missense	Large_intestine
COSM4921214	c.4752C>T	p.L1584L	Substitution - coding silent	Liver
COSM420722	c.1317G>C	p.Q439H	Substitution - Missense	Urinary_tract
COSM3919994	c.3433C>T	p.R1145C	Substitution - Missense	Skin
COSM1634215	c.6042A>G	p.K2014K	Substitution - coding silent	Liver
COSM5033569	c.1822C>T	p.L608F	Substitution - Missense	Skin
COSM1067729	c.7502G>A	p.R2501Q	Substitution - Missense	Endometrium
COSM325951	c.1868C>G	p.S623C	Substitution - Missense	Lung
COSM136474	c.6709C>T	p.L2237F	Substitution - Missense	Skin
COSM4706994	c.7038_7039insA	p.Y2349fs*41	Insertion - Frameshift	Large_intestine
COSM4778240	c.7100T>C	p.V2367A	Substitution - Missense	Prostate
COSM1181004	c.8320delA	p.I2776fs*3	Deletion - Frameshift	Large_intestine
COSM1437282	c.4914A>C	p.L1638F	Substitution - Missense	Large_intestine
COSM3994300	c.1706A>T	p.E569V	Substitution - Missense	Kidney
COSM1437262	c.1801delA	p.K603fs*11	Deletion - Frameshift	Large_intestine
COSM131339	c.3773C>T	p.S1258L	Substitution - Missense	Liver
COSM1067723	c.7220G>A	p.R2407Q	Substitution - Missense	Endometrium
COSM5515046	c.3976G>T	p.A1326S	Substitution - Missense	Biliary_tract
COSM1620275	c.7352A>G	p.H2451R	Substitution - Missense	Liver
COSM4976131	c.998A>T	p.K333M	Substitution - Missense	Oesophagus
COSM5560542	c.1838T>C	p.M613T	Substitution - Missense	Prostate
COSM3975518	c.430C>T	p.Q144*	Substitution - Nonsense	Central_nervous_system
COSM1437278	c.4261C>T	p.P1421S	Substitution - Missense	Large_intestine
COSM1734395	c.7912G>T	p.E2638*	Substitution - Nonsense	Pancreas
COSM3744852	c.5227A>T	p.M1743L	Substitution - Missense	Liver
COSM4817460	c.7330G>A	p.E2444K	Substitution - Missense	Cervix
COSM5787361	c.7524T>G	p.D2508E	Substitution - Missense	Breast
COSM2687960	c.5021A>G	p.K1674R	Substitution - Missense	Large_intestine
COSM4996552	c.728C>T	p.S243L	Substitution - Missense	Upper_aerodigestive_tract
COSM1671596	c.8212C>T	p.Q2738*	Substitution - Nonsense	Haematopoietic_and_lymphoid_tissue
COSM328564	c.423T>A	p.N141K	Substitution - Missense	Kidney
COSM5652129	c.6863A>G	p.E2288G	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3615944	c.3027T>C	p.S1009S	Substitution - coding silent	Skin
COSM1437262	c.1801delA	p.K603fs*11	Deletion - Frameshift	Large_intestine
COSM3855051	c.7488A>G	p.E2496E	Substitution - coding silent	Stomach
COSM4790890	c.545G>T	p.S182I	Substitution - Missense	Liver
COSM3827993	c.1498A>G	p.K500E	Substitution - Missense	Breast
COSM5797122	c.6694C>T	p.Q2232*	Substitution - Nonsense	Breast
COSM1159417	c.790A>G	p.M264V	Substitution - Missense	Pancreas
COSM3947482	c.2097G>A	p.R699R	Substitution - coding silent	Lung
COSM4141792	c.6450A>G	p.L2150L	Substitution - coding silent	Ovary
COSM2687970	c.5406A>G	p.V1802V	Substitution - coding silent	Large_intestine
COSM5996226	c.449G>T	p.S150I	Substitution - Missense	Prostate
COSM26610	c.5250T>C	p.Y1750Y	Substitution - coding silent	Kidney
COSM3855041	c.5573T>C	p.L1858S	Substitution - Missense	Stomach
COSM366505	c.5600G>C	p.R1867T	Substitution - Missense	Lung
COSM138478	c.3451C>T	p.P1151S	Substitution - Missense	Skin
COSM4802358	c.1236C>T	p.R412R	Substitution - coding silent	Liver
COSM4988407	c.7423G>A	p.D2475N	Substitution - Missense	Soft_tissue
COSM1158654	c.1581G>A	p.E527E	Substitution - coding silent	Pancreas
COSM4706970	c.1217C>G	p.T406S	Substitution - Missense	Large_intestine
COSM3927489	c.6764-4G>A	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM5744321	c.724G>A	p.G242S	Substitution - Missense	Small_intestine
COSM3827999	c.2121T>G	p.G707G	Substitution - coding silent	Breast
COSM1437303	c.6182C>T	p.P2061L	Substitution - Missense	Large_intestine
COSM1067695	c.5366G>A	p.R1789Q	Substitution - Missense	Endometrium
COSM289025	c.6205A>G	p.I2069V	Substitution - Missense	Large_intestine
COSM1437260	c.1624A>G	p.S542G	Substitution - Missense	Large_intestine
COSM4141788	c.1640A>G	p.Q547R	Substitution - Missense	Ovary
COSM1757126	c.2134G>C	p.E712Q	Substitution - Missense	Urinary_tract
COSM4655364	c.6007G>A	p.V2003I	Substitution - Missense	Large_intestine
COSM339492	c.7891G>A	p.D2631N	Substitution - Missense	Lung
COSM4746989	c.2246delA	p.N751fs*43	Deletion - Frameshift	Stomach
COSM1437280	c.4484T>C	p.L1495S	Substitution - Missense	Large_intestine
COSM1067691	c.5240C>T	p.T1747I	Substitution - Missense	Endometrium
COSM5615537	c.824C>T	p.P275L	Substitution - Missense	Lung
COSM3854997	c.247C>A	p.L83I	Substitution - Missense	Stomach
COSM3855015	c.3432T>C	p.G1144G	Substitution - coding silent	Stomach
COSM3855053	c.7840A>G	p.I2614V	Substitution - Missense	Stomach
COSM1067731	c.7603G>A	p.E2535K	Substitution - Missense	Endometrium
COSM1754256	c.942C>T	p.I314I	Substitution - coding silent	Urinary_tract
COSM3697225	c.3445C>T	p.R1149*	Substitution - Nonsense	Large_intestine
COSM1067737	c.7937G>A	p.R2646Q	Substitution - Missense	Endometrium
COSM1620267	c.2965A>G	p.I989V	Substitution - Missense	Liver
COSM1634215	c.6042A>G	p.K2014K	Substitution - coding silent	Liver
COSM3828005	c.3301G>T	p.E1101*	Substitution - Nonsense	Breast
COSM3410254	c.8390C>T	p.A2797V	Substitution - Missense	Oesophagus
COSM5041291	c.4228A>G	p.T1410A	Substitution - Missense	Liver
COSM328564	c.423T>A	p.N141K	Substitution - Missense	Kidney
COSM4791367	c.1391C>T	p.P464L	Substitution - Missense	Liver
COSM3855027	c.5037G>A	p.Q1679Q	Substitution - coding silent	Stomach
COSM1671590	c.7201G>T	p.G2401*	Substitution - Nonsense	Lung
COSM3615956	c.4950A>T	p.Q1650H	Substitution - Missense	Skin
COSM3828015	c.6454C>T	p.R2152W	Substitution - Missense	Breast
COSM1757130	c.3379G>A	p.D1127N	Substitution - Missense	Urinary_tract
COSM4706978	c.3625A>G	p.I1209V	Substitution - Missense	Large_intestine
COSM25310	c.1045A>T	p.S349C	Substitution - Missense	Lung
COSM1437305	c.6194T>G	p.F2065C	Substitution - Missense	Large_intestine
COSM2687920	c.4241T>C	p.V1414A	Substitution - Missense	Large_intestine
COSM3381254	c.7860+10A>G	p.?	Unknown	Pancreas
COSM283257	c.2500C>T	p.R834*	Substitution - Nonsense	Breast
COSM3729301	c.1592C>T	p.T531M	Substitution - Missense	Stomach
COSM4832772	c.1998C>T	p.S666S	Substitution - coding silent	Cervix
COSM5570775	c.4923T>G	p.V1641V	Substitution - coding silent	Prostate
COSM328564	c.423T>A	p.N141K	Substitution - Missense	Kidney
COSM5679758	c.537C>T	p.A179A	Substitution - coding silent	Soft_tissue
COSM3919994	c.3433C>T	p.R1145C	Substitution - Missense	Skin
COSM4409957	c.7955C>T	p.S2652L	Substitution - Missense	Oesophagus
COSM2687855	c.3125G>A	p.S1042N	Substitution - Missense	Large_intestine
COSM75603	c.5069A>G	p.K1690R	Substitution - Missense	Ovary
COSM1067639	c.112A>C	p.K38Q	Substitution - Missense	Endometrium
COSM1726409	c.5666G>C	p.C1889S	Substitution - Missense	Liver
COSM737902	c.3969G>T	p.M1323I	Substitution - Missense	Lung
COSM3615940	c.2177A>T	p.K726I	Substitution - Missense	Skin
COSM3715066	c.4934A>G	p.E1645G	Substitution - Missense	Upper_aerodigestive_tract
COSM737906	c.3354A>G	p.E1118E	Substitution - coding silent	Lung
COSM1671594	c.8108A>G	p.E2703G	Substitution - Missense	Large_intestine
COSM3947484	c.2671G>C	p.D891H	Substitution - Missense	Lung
COSM1067701	c.5710-1G>T	p.?	Unknown	Endometrium
COSM4790890	c.545G>T	p.S182I	Substitution - Missense	Liver
COSM1067649	c.1091G>A	p.R364H	Substitution - Missense	Breast
COSM3828003	c.2877G>A	p.P959P	Substitution - coding silent	Breast
COSM1328822	c.3559A>T	p.K1187*	Substitution - Nonsense	Ovary
COSM162914	c.5822G>C	p.R1941T	Substitution - Missense	Breast
COSM1328818	c.7765C>T	p.H2589Y	Substitution - Missense	Ovary
COSM1620269	c.3929C>T	p.A1310V	Substitution - Missense	Skin
COSM2687839	c.2650G>T	p.G884W	Substitution - Missense	Lung
COSM1067705	c.5963C>A	p.S1988Y	Substitution - Missense	Endometrium
COSM257519	c.1880A>C	p.E627A	Substitution - Missense	Large_intestine
COSM404917	c.6939_6940insAA	p.I2314fs*11	Insertion - Frameshift	Lung
COSM5438473	c.8162G>A	p.R2721Q	Substitution - Missense	Oesophagus
COSM3827995	c.1548T>G	p.G516G	Substitution - coding silent	Breast
COSM4185570	c.6343G>A	p.G2115S	Substitution - Missense	Kidney
COSM2687988	c.5690A>G	p.N1897S	Substitution - Missense	Stomach
COSM1067689	c.5025C>A	p.F1675L	Substitution - Missense	Endometrium
COSM253036	c.7894_7896delGAA	p.E2632delE	Deletion - In frame	Ovary
COSM1067697	c.5538T>C	p.A1846A	Substitution - coding silent	Endometrium
COSM3855011	c.2158G>T	p.G720W	Substitution - Missense	Stomach
COSM1486739	c.1309T>G	p.L437V	Substitution - Missense	Breast
COSM2687777	c.1235G>A	p.R412H	Substitution - Missense	Pancreas
COSM3828017	c.6815C>T	p.S2272L	Substitution - Missense	Breast
COSM1328824	c.3071delC	p.S1024fs*1	Deletion - Frameshift	Ovary
COSM1581320	c.185T>G	p.V62G	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1437262	c.1801delA	p.K603fs*11	Deletion - Frameshift	Large_intestine
COSM5975594	c.1979A>G	p.E660G	Substitution - Missense	Upper_aerodigestive_tract
COSM2687882	c.3465C>T	p.D1155D	Substitution - coding silent	Large_intestine
COSM4791367	c.1391C>T	p.P464L	Substitution - Missense	Liver
COSM121308	c.6057C>T	p.L2019L	Substitution - coding silent	Upper_aerodigestive_tract
COSM328564	c.423T>A	p.N141K	Substitution - Missense	Kidney
COSM3854995	c.179A>G	p.N60S	Substitution - Missense	Stomach
COSM1067677	c.4140G>A	p.Q1380Q	Substitution - coding silent	Endometrium
COSM5689779	c.33T>C	p.T11T	Substitution - coding silent	Soft_tissue
COSM5918708	c.3104C>T	p.P1035L	Substitution - Missense	Skin
COSM3919994	c.3433C>T	p.R1145C	Substitution - Missense	Skin
COSM1067721	c.7208G>A	p.R2403H	Substitution - Missense	Endometrium
COSM5975592	c.1172C>T	p.P391L	Substitution - Missense	Upper_aerodigestive_tract
COSM5761502	c.535G>A	p.A179T	Substitution - Missense	Pancreas
COSM117819	c.4937A>G	p.D1646G	Substitution - Missense	Ovary
COSM4601579	c.2171C>G	p.T724S	Substitution - Missense	Upper_aerodigestive_tract
COSM3827989	c.1105G>A	p.D369N	Substitution - Missense	Breast
COSM5898267	c.6955-4C>T	p.?	Unknown	Skin
COSM3365769	c.102T>A	p.A34A	Substitution - coding silent	Kidney
COSM5737201	c.2323_2324insA	p.P777fs*2	Insertion - Frameshift	Small_intestine
COSM1067637	c.13A>G	p.M5V	Substitution - Missense	Endometrium
COSM2688067	c.7753G>A	p.G2585R	Substitution - Missense	Large_intestine
COSM482769	c.3924G>A	p.A1308A	Substitution - coding silent	Kidney
COSM1671594	c.8108A>G	p.E2703G	Substitution - Missense	Large_intestine
COSM4826844	c.7889C>T	p.P2630L	Substitution - Missense	Cervix
COSM4615086	c.344_348delGATAT	p.R115fs*11	Deletion - Frameshift	Large_intestine
COSM345752	c.1585G>T	p.G529C	Substitution - Missense	Lung
COSM4496212	c.4704C>T	p.D1568D	Substitution - coding silent	Skin
COSM1663064	c.50C>A	p.A17D	Substitution - Missense	Kidney
COSM3736917	c.2021A>G	p.N674S	Substitution - Missense	Large_intestine
COSM5726404	c.1864G>A	p.E622K	Substitution - Missense	Skin
COSM236015	c.928G>A	p.V310I	Substitution - Missense	Autonomic_ganglia
COSM1259131	c.6893G>A	p.R2298H	Substitution - Missense	Oesophagus
COSM75604	c.5752A>G	p.T1918A	Substitution - Missense	Ovary
COSM1437262	c.1801delA	p.K603fs*11	Deletion - Frameshift	Large_intestine
COSM4155813	c.5591T>G	p.V1864G	Substitution - Missense	Kidney
COSM5564859	c.5782A>G	p.R1928G	Substitution - Missense	Prostate
COSM249617	c.3410_3412delGAA	p.R1139delR	Deletion - In frame	Kidney
COSM3410254	c.8390C>T	p.A2797V	Substitution - Missense	Central_nervous_system
COSM5585924	c.5375C>T	p.A1792V	Substitution - Missense	Skin
COSM1067681	c.4607G>A	p.R1536Q	Substitution - Missense	Endometrium
COSM5344934	c.3888G>A	p.W1296*	Substitution - Nonsense	Large_intestine
COSM449594	c.3923C>T	p.A1308V	Substitution - Missense	Stomach
COSM322031	c.611-1G>T	p.?	Unknown	Lung
COSM32496	c.4939G>A	p.E1647K	Substitution - Missense	Breast
COSM4706984	c.5295G>A	p.P1765P	Substitution - coding silent	Large_intestine
COSM5797122	c.6694C>T	p.Q2232*	Substitution - Nonsense	Breast
COSM1067695	c.5366G>A	p.R1789Q	Substitution - Missense	Endometrium
COSM4706980	c.4263_4264insT	p.V1424fs*6	Insertion - Frameshift	Large_intestine
COSM2687722	c.165T>C	p.A55A	Substitution - coding silent	Upper_aerodigestive_tract
COSM162915	c.7744C>T	p.R2582*	Substitution - Nonsense	Large_intestine
COSM1437301	c.6035T>C	p.F2012S	Substitution - Missense	Large_intestine
COSM3365771	c.8274A>G	p.K2758K	Substitution - coding silent	Kidney
COSM5756656	c.3518A>C	p.K1173T	Substitution - Missense	Large_intestine
COSM3855017	c.3716A>C	p.N1239T	Substitution - Missense	Stomach
COSM3855005	c.1593G>A	p.T531T	Substitution - coding silent	Stomach
COSM4912567	c.1164T>A	p.N388K	Substitution - Missense	Liver
COSM1437311	c.7003C>T	p.R2335W	Substitution - Missense	Large_intestine
COSM222993	c.6191C>T	p.T2064I	Substitution - Missense	Skin
COSM1757132	c.3895C>G	p.L1299V	Substitution - Missense	Urinary_tract
COSM1067707	c.6302A>C	p.Q2101P	Substitution - Missense	Endometrium
COSM253036	c.7894_7896delGAA	p.E2632delE	Deletion - In frame	Endometrium
COSM592268	c.8270G>A	p.R2757H	Substitution - Missense	Prostate
COSM1486741	c.5272C>T	p.R1758*	Substitution - Nonsense	Breast
COSM3615960	c.6717C>A	p.T2239T	Substitution - coding silent	Skin
COSM5666697	c.2920A>G	p.K974E	Substitution - Missense	Soft_tissue
COSM232879	c.5597A>G	p.K1866R	Substitution - Missense	Skin
COSM4552850	c.5733G>A	p.Q1911Q	Substitution - coding silent	Skin
COSM1217356	c.5044C>T	p.R1682*	Substitution - Nonsense	Large_intestine
COSM328564	c.423T>A	p.N141K	Substitution - Missense	Kidney
COSM269720	c.1981T>C	p.C661R	Substitution - Missense	Large_intestine
COSM5995790	c.2261G>A	p.R754Q	Substitution - Missense	Prostate
COSM5737203	c.2713T>C	p.S905P	Substitution - Missense	Small_intestine
COSM3393547	c.5595G>A	p.R1865R	Substitution - coding silent	Pancreas
COSM1067641	c.462G>A	p.R154R	Substitution - coding silent	Endometrium
COSM4900622	c.7056C>T	p.F2352F	Substitution - coding silent	Skin
COSM3661808	c.819A>T	p.R273S	Substitution - Missense	Liver
COSM5445583	c.1290A>T	p.P430P	Substitution - coding silent	Oesophagus
COSM1671592	c.7333G>C	p.E2445Q	Substitution - Missense	Lung
COSM138478	c.3451C>T	p.P1151S	Substitution - Missense	Skin
COSM1732443	c.4677A>T	p.R1559S	Substitution - Missense	Bone
COSM3736917	c.2021A>G	p.N674S	Substitution - Missense	Soft_tissue
COSM5995792	c.4797G>A	p.K1599K	Substitution - coding silent	Prostate
COSM1067661	c.2022T>C	p.N674N	Substitution - coding silent	Endometrium
COSM5823554	c.640G>A	p.G214S	Substitution - Missense	Liver
COSM1757128	c.2228G>A	p.R743H	Substitution - Missense	Urinary_tract
COSM186813	c.3659C>T	p.A1220V	Substitution - Missense	Large_intestine
COSM5996129	c.7410+6T>G	p.?	Unknown	Prostate
COSM592268	c.8270G>A	p.R2757H	Substitution - Missense	Kidney
COSM1067685	c.4917A>G	p.K1639K	Substitution - coding silent	Endometrium
COSM3615954	c.4822G>C	p.A1608P	Substitution - Missense	Skin
COSM3855025	c.4907G>A	p.R1636H	Substitution - Missense	Stomach
COSM1757130	c.3379G>A	p.D1127N	Substitution - Missense	Urinary_tract
COSM1067709	c.6522T>C	p.L2174L	Substitution - coding silent	Endometrium
COSM5731415	c.6556_6558delGAA	p.E2187delE	Deletion - In frame	Central_nervous_system
COSM4706982	c.4660G>A	p.G1554S	Substitution - Missense	Large_intestine
COSM3828013	c.5926G>C	p.D1976H	Substitution - Missense	Breast
COSM328564	c.423T>A	p.N141K	Substitution - Missense	Kidney
COSM3615948	c.3172G>A	p.E1058K	Substitution - Missense	Skin
COSM5356977	c.610+1G>T	p.?	Unknown	Large_intestine
COSM4929589	c.4894G>C	p.G1632R	Substitution - Missense	Liver
COSM1437307	c.6513T>G	p.D2171E	Substitution - Missense	Large_intestine
COSM5356561	c.5628T>C	p.C1876C	Substitution - coding silent	Large_intestine
COSM3615932	c.1068T>C	p.T356T	Substitution - coding silent	Skin
COSM1437309	c.6655_6656insT	p.L2220fs*3	Insertion - Frameshift	Large_intestine
COSM3615930	c.979A>G	p.K327E	Substitution - Missense	Skin
COSM1067659	c.1942A>G	p.T648A	Substitution - Missense	Endometrium
COSM1620269	c.3929C>T	p.A1310V	Substitution - Missense	Skin
COSM2688034	c.7133C>T	p.P2378L	Substitution - Missense	Skin
COSM4840400	c.6337T>G	p.Y2113D	Substitution - Missense	Cervix
COSM4628427	c.6982A>G	p.T2328A	Substitution - Missense	Large_intestine
COSM2688006	c.6228C>T	p.L2076L	Substitution - coding silent	Skin
COSM3615950	c.3912T>A	p.V1304V	Substitution - coding silent	Skin
COSM5428940	c.2134G>T	p.E712*	Substitution - Nonsense	Oesophagus
COSM5813288	c.6992A>C	p.E2331A	Substitution - Missense	Liver
COSM1067713	c.6869T>G	p.F2290C	Substitution - Missense	Endometrium
COSM1437262	c.1801delA	p.K603fs*11	Deletion - Frameshift	Breast
COSM283259	c.7315C>T	p.P2439S	Substitution - Missense	Large_intestine
COSM5647905	c.7532C>G	p.S2511*	Substitution - Nonsense	Oesophagus
COSM5466444	c.2253T>G	p.N751K	Substitution - Missense	Large_intestine
COSM3919994	c.3433C>T	p.R1145C	Substitution - Missense	Skin
COSM186829	c.5680C>T	p.R1894C	Substitution - Missense	Large_intestine
COSM1437262	c.1801delA	p.K603fs*11	Deletion - Frameshift	Large_intestine
COSM1437262	c.1801delA	p.K603fs*11	Deletion - Frameshift	Large_intestine
COSM3429421	c.6480T>G	p.D2160E	Substitution - Missense	Large_intestine
COSM482773	c.5011-1G>T	p.?	Unknown	Kidney
COSM3661808	c.819A>T	p.R273S	Substitution - Missense	Liver
COSM3855033	c.5167C>T	p.R1723*	Substitution - Nonsense	Stomach
COSM1620275	c.7352A>G	p.H2451R	Substitution - Missense	Liver
COSM186813	c.3659C>T	p.A1220V	Substitution - Missense	Large_intestine
COSM3661810	c.4040C>T	p.T1347I	Substitution - Missense	Liver
COSM2688102	c.8217G>A	p.W2739*	Substitution - Nonsense	Adrenal_gland
COSM1239602	c.133C>T	p.R45*	Substitution - Nonsense	Oesophagus
COSM4490130	c.3585C>T	p.D1195D	Substitution - coding silent	Skin
COSM3736917	c.2021A>G	p.N674S	Substitution - Missense	Breast
COSM5036521	c.3139G>T	p.V1047L	Substitution - Missense	Oesophagus
COSM1671588	c.5668G>T	p.V1890L	Substitution - Missense	Central_nervous_system
COSM1620267	c.2965A>G	p.I989V	Substitution - Missense	Liver
COSM1666057	c.3743_3744insA	p.A1250fs*7	Insertion - Frameshift	Kidney
COSM3615942	c.2875C>T	p.P959S	Substitution - Missense	Skin
COSM4186536	c.3697delT	p.L1233fs*1	Deletion - Frameshift	Kidney
COSM4930011	c.1352C>T	p.S451F	Substitution - Missense	Liver
COSM1067647	c.981G>T	p.K327N	Substitution - Missense	Endometrium
COSM2687986	c.5681G>A	p.R1894H	Substitution - Missense	Stomach
COSM4706998	c.7795A>G	p.S2599G	Substitution - Missense	Large_intestine
COSM1067715	c.6939T>C	p.L2313L	Substitution - coding silent	Endometrium
COSM1437262	c.1801delA	p.K603fs*11	Deletion - Frameshift	Large_intestine
COSM267026	c.2128C>T	p.R710W	Substitution - Missense	Large_intestine
COSM3410253	c.8067A>G	p.K2689K	Substitution - coding silent	Central_nervous_system
COSM3975520	c.4328C>G	p.S1443*	Substitution - Nonsense	Central_nervous_system
COSM1181004	c.8320delA	p.I2776fs*3	Deletion - Frameshift	Large_intestine
COSM1158654	c.1581G>A	p.E527E	Substitution - coding silent	Pancreas
COSM3828001	c.2250A>C	p.K750N	Substitution - Missense	Breast
COSM1695619	c.6150C>G	p.I2050M	Substitution - Missense	Skin
COSM5978968	c.2245_2246insA	p.N751fs*2	Insertion - Frameshift	Upper_aerodigestive_tract
COSM5018595	c.1662delG	p.A555fs*3	Deletion - Frameshift	Soft_tissue
COSM1067693	c.5273G>A	p.R1758Q	Substitution - Missense	Endometrium
COSM3697227	c.6956G>A	p.C2319Y	Substitution - Missense	Large_intestine
COSM4618518	c.5047G>A	p.D1683N	Substitution - Missense	Large_intestine
COSM1437258	c.1507delA	p.R505fs*35	Deletion - Frameshift	Large_intestine
COSM3615946	c.3078T>G	p.S1026R	Substitution - Missense	Skin
COSM3736917	c.2021A>G	p.N674S	Substitution - Missense	Soft_tissue
COSM3855009	c.2035T>A	p.S679T	Substitution - Missense	Stomach
COSM1581322	c.2785G>C	p.D929H	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM2687924	c.4399A>G	p.K1467E	Substitution - Missense	Central_nervous_system
COSM186829	c.5680C>T	p.R1894C	Substitution - Missense	Large_intestine
COSM1437262	c.1801delA	p.K603fs*11	Deletion - Frameshift	Pancreas
COSM3919994	c.3433C>T	p.R1145C	Substitution - Missense	Skin
COSM121309	c.7146C>T	p.F2382F	Substitution - coding silent	Upper_aerodigestive_tract
COSM1067653	c.1263G>A	p.S421S	Substitution - coding silent	Endometrium
COSM1437316	c.8221G>A	p.A2741T	Substitution - Missense	Large_intestine
COSM4706980	c.4263_4264insT	p.V1424fs*6	Insertion - Frameshift	Breast
COSM1067671	c.3440G>A	p.R1147Q	Substitution - Missense	Endometrium
COSM88612	c.862C>A	p.P288T	Substitution - Missense	Ovary
COSM1695615	c.1839G>T	p.M613I	Substitution - Missense	Skin
COSM5636317	c.5106A>G	p.E1702E	Substitution - coding silent	Oesophagus
COSM1685810	c.7480_7482delGAA	p.E2496delE	Deletion - In frame	Skin
COSM5887884	c.5428-6C>T	p.?	Unknown	Upper_aerodigestive_tract
COSM3827985	c.677C>T	p.P226L	Substitution - Missense	Breast
COSM5095473	c.6319T>G	p.W2107G	Substitution - Missense	Thymus
COSM1437276	c.3861C>T	p.N1287N	Substitution - coding silent	Large_intestine
COSM2687787	c.1583C>T	p.T528M	Substitution - Missense	Central_nervous_system
COSM449594	c.3923C>T	p.A1308V	Substitution - Missense	Breast
COSM5703182	c.733G>T	p.E245*	Substitution - Nonsense	Autonomic_ganglia
COSM2687766	c.966A>G	p.K322K	Substitution - coding silent	Large_intestine
COSM328564	c.423T>A	p.N141K	Substitution - Missense	Kidney
COSM5715614	c.1978G>T	p.E660*	Substitution - Nonsense	Skin
COSM4706986	c.5587A>C	p.S1863R	Substitution - Missense	Large_intestine
COSM222991	c.4307A>G	p.K1436R	Substitution - Missense	Skin
COSM1739175	c.2T>A	p.M1K	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3776667	c.4729G>A	p.E1577K	Substitution - Missense	Urinary_tract
COSM328564	c.423T>A	p.N141K	Substitution - Missense	Kidney
COSM5890110	c.1531C>T	p.P511S	Substitution - Missense	Skin
COSM186813	c.3659C>T	p.A1220V	Substitution - Missense	Lung
COSM222989	c.3154C>T	p.P1052S	Substitution - Missense	Skin
COSM5697982	c.6688A>G	p.K2230E	Substitution - Missense	Soft_tissue
COSM5515044	c.3439C>T	p.R1147*	Substitution - Nonsense	Biliary_tract
COSM4434078	c.3730G>T	p.E1244*	Substitution - Nonsense	Oesophagus
COSM3855003	c.649A>C	p.N217H	Substitution - Missense	Stomach
COSM1132160	c.6092T>A	p.L2031H	Substitution - Missense	Prostate
COSM1181004	c.8320delA	p.I2776fs*3	Deletion - Frameshift	Biliary_tract
COSM3732724	c.421A>G	p.N141D	Substitution - Missense	Stomach
COSM3855045	c.6365G>A	p.S2122N	Substitution - Missense	Stomach
COSM5356977	c.610+1G>T	p.?	Unknown	Large_intestine
COSM1217358	c.1810T>A	p.S604T	Substitution - Missense	Large_intestine
COSM5627365	c.8299A>G	p.K2767E	Substitution - Missense	Oesophagus
COSM1067645	c.962G>T	p.R321I	Substitution - Missense	Endometrium
COSM449592	c.2675G>T	p.S892I	Substitution - Missense	Breast
COSM4876516	c.6043A>G	p.I2015V	Substitution - Missense	Prostate
COSM3615962	c.6831C>T	p.S2277S	Substitution - coding silent	Skin
COSM3736917	c.2021A>G	p.N674S	Substitution - Missense	Soft_tissue
COSM4802358	c.1236C>T	p.R412R	Substitution - coding silent	Liver
COSM3393549	c.5808+4A>G	p.?	Unknown	Pancreas
COSM22155	c.6721_6724delCTAC	p.L2241fs*23	Deletion - Frameshift	Lung

> Text Mining based Variations [ TOP ]
There is no record for NIPBL.

Summary
Symbol	NIPBL
Name	NIPBL, cohesin loading factor
Aliases	IDN3; DKFZp434L1319; FLJ11203; FLJ12597; FLJ13354; FLJ13648; Scc2; sister chromatid cohesion 2 homolog (yeas ......
Location	5p13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

[ TOP ]

Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
Q6KC79	162	S	Phosphoserine	-	No	None detected
Q6KC79	243	S	Phosphoserine	-	No	None detected
Q6KC79	256	S	Phosphoserine	-	No	None detected
Q6KC79	274	S	Phosphoserine	-	No	None detected
Q6KC79	280	S	Phosphoserine	-	No	None detected
Q6KC79	284	S	Phosphoserine	-	Yes	p.S284C (cancer: ESCA)
Q6KC79	301	S	Phosphoserine	-	No	None detected
Q6KC79	306	S	Phosphoserine	-	No	None detected
Q6KC79	318	S	Phosphoserine	-	No	None detected
Q6KC79	350	S	Phosphoserine	-	No	None detected
Q6KC79	713	T	Phosphothreonine	-	No	None detected
Q6KC79	746	T	Phosphothreonine	-	No	None detected
Q6KC79	912	S	Phosphoserine	-	Yes	p.S912P (cancer: STAD)
Q6KC79	1082	K	N6-acetyllysine	-	No	None detected
Q6KC79	1089	S	Phosphoserine	-	No	None detected
Q6KC79	1090	S	Phosphoserine	-	No	None detected
Q6KC79	1096	S	Phosphoserine	-	No	None detected
Q6KC79	1150	S	Phosphoserine	-	No	None detected
Q6KC79	1152	S	Phosphoserine	-	No	None detected
Q6KC79	1154	S	Phosphoserine	-	No	None detected
Q6KC79	1159	Y	Phosphotyrosine	-	No	None detected
Q6KC79	1160	S	Phosphoserine	-	No	None detected
Q6KC79	1189	T	Phosphothreonine	-	No	None detected
Q6KC79	1197	S	Phosphoserine	-	No	None detected
Q6KC79	2493	S	Phosphoserine	-	No	None detected
Q6KC79	2509	S	Phosphoserine	-	No	None detected
Q6KC79	2511	S	Phosphoserine	-	No	None detected
Q6KC79	2513	S	Phosphoserine	-	No	None detected
Q6KC79	2515	S	Phosphoserine	-	No	None detected
Q6KC79	2652	S	Phosphoserine	-	No	None detected
Q6KC79	2658	S	Phosphoserine	-	No	None detected
Q6KC79	2667	T	Phosphothreonine	-	No	None detected
Q6KC79	2672	S	Phosphoserine	-	No	None detected

Summary
Symbol	NIPBL
Name	NIPBL, cohesin loading factor
Aliases	IDN3; DKFZp434L1319; FLJ11203; FLJ12597; FLJ13354; FLJ13648; Scc2; sister chromatid cohesion 2 homolog (yeas ......
Location	5p13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	6.459	6.298	-0.039	0.825	NS
BRCA	Breast invasive carcinoma	112	1100	7.008	6.804	-0.224	0.000163	NS
CESC	Cervical and endocervical cancers	3	306	6.338	6.456	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	6.15	5.945	-0.245	0.0225	NS
ESCA	Esophageal carcinoma	11	185	6.974	6.999	0.105	0.66	NS
GBM	Glioblastoma multiforme	5	166	5.789	5.657	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	6.33	6.355	0.066	0.536	NS
KIRC	Kidney renal clear cell carcinoma	72	534	6.486	6.244	-0.22	0.000185	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	6.198	5.945	-0.254	0.026	NS
LAML	Acute Myeloid Leukemia	0	173	NA	7.978	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	6.401	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	5.158	5.156	0.065	0.422	NS
LUAD	Lung adenocarcinoma	59	517	6.402	6.367	0.111	0.225	NS
LUSC	Lung squamous cell carcinoma	51	501	6.326	6.577	0.302	0.00149	NS
OV	Ovarian serous cystadenocarcinoma	0	307	NA	6.154	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	6.398	6.214	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	5.682	5.814	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	6.34	6.122	-0.229	0.00146	NS
READ	Rectum adenocarcinoma	10	167	6.196	6.009	-0.194	0.506	NS
SARC	Sarcoma	2	263	5.518	6.189	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	6.09	6.074	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	6.46	6.815	0.322	0.00171	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	6.517	NA	NA	NA
THCA	Thyroid carcinoma	59	509	6.776	6.357	-0.358	1.84e-10	NS
THYM	Thymoma	2	120	7.052	6.652	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	6.386	6.017	-0.364	6.46e-05	NS

> Cancer Cell Line Encyclopedia (CCLE)

[ TOP ]

Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	8.4
Autonomic ganglia	CHP212	8.3
Autonomic ganglia	IMR32	8.9
Autonomic ganglia	KELLY	8.6
Autonomic ganglia	KPNRTBM1	8.6
Autonomic ganglia	KPNSI9S	8.5
Autonomic ganglia	KPNYN	8.7
Autonomic ganglia	MHHNB11	8.2
Autonomic ganglia	NB1	8.8
Autonomic ganglia	NH6	8.5
Autonomic ganglia	SHSY5Y	9
Autonomic ganglia	SIMA	8.8
Autonomic ganglia	SKNAS	8.2
Autonomic ganglia	SKNBE2	8.5
Autonomic ganglia	SKNDZ	8.5
Autonomic ganglia	SKNFI	8.5
Autonomic ganglia	SKNSH	8
Biliary tract	HUCCT1	8.2
Biliary tract	HUH28	8.6
Biliary tract	SNU1079	8.1
Biliary tract	SNU1196	7.8
Biliary tract	SNU245	8.7
Biliary tract	SNU308	7.9
Biliary tract	SNU478	8.1
Bone	143B	8.8
Bone	A673	8.6
Bone	CADOES1	8.8
Bone	CAL78	8.3
Bone	G292CLONEA141B1	8.1
Bone	HOS	9.5
Bone	HS706T	8
Bone	HS737T	7.5
Bone	HS819T	7.6
Bone	HS821T	7.9
Bone	HS822T	7.8
Bone	HS863T	7.9
Bone	HS870T	7.9
Bone	HS888T	8.2
Bone	MG63	8.3
Bone	MHHES1	9.2
Bone	OUMS27	8.9
Bone	RDES	8.9
Bone	SJSA1	8.4
Bone	SKES1	8.3
Bone	SKNMC	8.9
Bone	SW1353	7.9
Bone	T173	7.6
Bone	TC71	8.2
Bone	U2OS	8.8
Breast	AU565	8.5
Breast	BT20	9.3
Breast	BT474	9.4
Breast	BT483	8.8
Breast	BT549	8
Breast	CAL120	9.1
Breast	CAL148	8.3
Breast	CAL51	9
Breast	CAL851	8.7
Breast	CAMA1	8.6
Breast	DU4475	8.8
Breast	EFM192A	8.6
Breast	EFM19	7
Breast	EVSAT	8.9
Breast	HCC1143	8.5
Breast	HCC1187	8.6
Breast	HCC1395	8.7
Breast	HCC1419	8.5
Breast	HCC1428	8
Breast	HCC1500	8.9
Breast	HCC1569	7.4
Breast	HCC1599	7.3
Breast	HCC1806	9.6
Breast	HCC1937	9
Breast	HCC1954	8.8
Breast	HCC202	8
Breast	HCC2157	8.5
Breast	HCC2218	8.4
Breast	HCC38	8.5
Breast	HCC70	9.6
Breast	HDQP1	9.9
Breast	HMC18	9.1
Breast	HS274T	8
Breast	HS281T	7.9
Breast	HS343T	8
Breast	HS578T	8.6
Breast	HS606T	7.9
Breast	HS739T	8
Breast	HS742T	7.6
Breast	JIMT1	8.1
Breast	KPL1	8.3
Breast	MCF7	8.3
Breast	MDAMB134VI	9
Breast	MDAMB157	8.6
Breast	MDAMB175VII	8.1
Breast	MDAMB231	8.3
Breast	MDAMB361	8.5
Breast	MDAMB415	9
Breast	MDAMB436	8.3
Breast	MDAMB453	8.9
Breast	MDAMB468	8
Breast	SKBR3	8.2
Breast	T47D	8.5
Breast	UACC812	8
Breast	UACC893	9.1
Breast	YMB1	8.1
Breast	ZR751	8.1
Breast	ZR7530	9.3
Central nervous system	1321N1	8
Central nervous system	42MGBA	9.1
Central nervous system	8MGBA	8.5
Central nervous system	A172	8
Central nervous system	AM38	8
Central nervous system	BECKER	8.2
Central nervous system	CAS1	8.1
Central nervous system	CCFSTTG1	7.7
Central nervous system	D283MED	9
Central nervous system	D341MED	9
Central nervous system	DAOY	8.2
Central nervous system	DBTRG05MG	7.8
Central nervous system	DKMG	8.4
Central nervous system	GAMG	8.1
Central nervous system	GB1	8.1
Central nervous system	GI1	8.6
Central nervous system	GMS10	8.3
Central nervous system	GOS3	8
Central nervous system	H4	8.5
Central nervous system	HS683	8.2
Central nervous system	KALS1	8.4
Central nervous system	KG1C	8.5
Central nervous system	KNS42	8.4
Central nervous system	KNS60	9.6
Central nervous system	KNS81	8.2
Central nervous system	KS1	8.5
Central nervous system	LN18	8.9
Central nervous system	LN229	8.6
Central nervous system	M059K	8.5
Central nervous system	MOGGCCM	7.8
Central nervous system	MOGGUVW	8.2
Central nervous system	NMCG1	8
Central nervous system	ONS76	8.1
Central nervous system	SF126	9.3
Central nervous system	SF295	8.3
Central nervous system	SNB19	7.7
Central nervous system	SNU1105	8
Central nervous system	SNU201	8.1
Central nervous system	SNU466	7.7
Central nervous system	SNU489	8.1
Central nervous system	SNU626	7.8
Central nervous system	SNU738	8.3
Central nervous system	SW1088	8.6
Central nervous system	SW1783	8.2
Central nervous system	T98G	8.5
Central nervous system	TM31	7.9
Central nervous system	U118MG	7.9
Central nervous system	U138MG	7.8
Central nervous system	U251MG	7.8
Central nervous system	U87MG	7.4
Central nervous system	YH13	8.3
Central nervous system	YKG1	8.3
Endometrium	AN3CA	7.6
Endometrium	COLO684	8
Endometrium	EFE184	7.9
Endometrium	EN	7.9
Endometrium	ESS1	7.8
Endometrium	HEC108	8.4
Endometrium	HEC151	7.4
Endometrium	HEC1A	8.2
Endometrium	HEC1B	8.7
Endometrium	HEC251	8.3
Endometrium	HEC265	7.3
Endometrium	HEC50B	7.9
Endometrium	HEC59	7.9
Endometrium	HEC6	8.9
Endometrium	ISHIKAWAHERAKLIO02ER	8.2
Endometrium	JHUEM1	7.3
Endometrium	JHUEM2	8.2
Endometrium	JHUEM3	8.3
Endometrium	KLE	7.3
Endometrium	MFE280	7.5
Endometrium	MFE296	8
Endometrium	MFE319	7.6
Endometrium	RL952	8.5
Endometrium	SNGM	8.1
Endometrium	SNU1077	8
Endometrium	SNU685	8.6
Endometrium	TEN	8.2
Haematopoietic and lymphoid	697	8.9
Haematopoietic and lymphoid	A3KAW	8.1
Haematopoietic and lymphoid	A4FUK	8.4
Haematopoietic and lymphoid	ALLSIL	9.2
Haematopoietic and lymphoid	AML193	9.1
Haematopoietic and lymphoid	AMO1	8.5
Haematopoietic and lymphoid	BCP1	8.5
Haematopoietic and lymphoid	BDCM	8.6
Haematopoietic and lymphoid	BL41	8.9
Haematopoietic and lymphoid	BL70	8.8
Haematopoietic and lymphoid	BV173	9.5
Haematopoietic and lymphoid	CA46	9
Haematopoietic and lymphoid	CI1	8.6
Haematopoietic and lymphoid	CMK115	9.6
Haematopoietic and lymphoid	CMK86	8.8
Haematopoietic and lymphoid	CMK	9.4
Haematopoietic and lymphoid	CMLT1	9.2
Haematopoietic and lymphoid	COLO775	8.3
Haematopoietic and lymphoid	DAUDI	8.8
Haematopoietic and lymphoid	DB	9.1
Haematopoietic and lymphoid	DEL	9.2
Haematopoietic and lymphoid	DND41	8.4
Haematopoietic and lymphoid	DOHH2	8.9
Haematopoietic and lymphoid	EB1	8.8
Haematopoietic and lymphoid	EB2	9.3
Haematopoietic and lymphoid	EHEB	8.7
Haematopoietic and lymphoid	EJM	8.2
Haematopoietic and lymphoid	EM2	9.5
Haematopoietic and lymphoid	EOL1	9.1
Haematopoietic and lymphoid	F36P	8.9
Haematopoietic and lymphoid	GA10	8.4
Haematopoietic and lymphoid	GDM1	8.8
Haematopoietic and lymphoid	GRANTA519	9.2
Haematopoietic and lymphoid	HDLM2	8.6
Haematopoietic and lymphoid	HDMYZ	8.4
Haematopoietic and lymphoid	HEL9217	9.2
Haematopoietic and lymphoid	HEL	9.4
Haematopoietic and lymphoid	HH	8.5
Haematopoietic and lymphoid	HL60	9.1
Haematopoietic and lymphoid	HPBALL	9.1
Haematopoietic and lymphoid	HS604T	7.7
Haematopoietic and lymphoid	HS611T	8.6
Haematopoietic and lymphoid	HS616T	7.6
Haematopoietic and lymphoid	HS751T	7.9
Haematopoietic and lymphoid	HT	9
Haematopoietic and lymphoid	HTK	8.1
Haematopoietic and lymphoid	HUNS1	8.6
Haematopoietic and lymphoid	HUT102	8.5
Haematopoietic and lymphoid	HUT78	8.5
Haematopoietic and lymphoid	JEKO1	8.6
Haematopoietic and lymphoid	JK1	9.2
Haematopoietic and lymphoid	JM1	9.2
Haematopoietic and lymphoid	JURKAT	8.8
Haematopoietic and lymphoid	JURLMK1	9.3
Haematopoietic and lymphoid	JVM2	8.6
Haematopoietic and lymphoid	JVM3	9
Haematopoietic and lymphoid	K562	8.6
Haematopoietic and lymphoid	KARPAS299	8.7
Haematopoietic and lymphoid	KARPAS422	9.1
Haematopoietic and lymphoid	KARPAS620	8.8
Haematopoietic and lymphoid	KASUMI1	9.2
Haematopoietic and lymphoid	KASUMI2	9.2
Haematopoietic and lymphoid	KASUMI6	9.2
Haematopoietic and lymphoid	KCL22	8.5
Haematopoietic and lymphoid	KE37	9.4
Haematopoietic and lymphoid	KE97	8.4
Haematopoietic and lymphoid	KG1	8.9
Haematopoietic and lymphoid	KHM1B	8.5
Haematopoietic and lymphoid	KIJK	8.5
Haematopoietic and lymphoid	KMH2	9.2
Haematopoietic and lymphoid	KMM1	8.6
Haematopoietic and lymphoid	KMS11	8.3
Haematopoietic and lymphoid	KMS12BM	8.7
Haematopoietic and lymphoid	KMS18	8.9
Haematopoietic and lymphoid	KMS20	8.3
Haematopoietic and lymphoid	KMS21BM	8.1
Haematopoietic and lymphoid	KMS26	7.9
Haematopoietic and lymphoid	KMS27	7.9
Haematopoietic and lymphoid	KMS28BM	8.4
Haematopoietic and lymphoid	KMS34	8.7
Haematopoietic and lymphoid	KO52	9.3
Haematopoietic and lymphoid	KOPN8	8
Haematopoietic and lymphoid	KU812	8.8
Haematopoietic and lymphoid	KYO1	8.7
Haematopoietic and lymphoid	L1236	7.9
Haematopoietic and lymphoid	L363	9.5
Haematopoietic and lymphoid	L428	8.5
Haematopoietic and lymphoid	L540	8.8
Haematopoietic and lymphoid	LAMA84	10
Haematopoietic and lymphoid	LOUCY	9
Haematopoietic and lymphoid	LP1	9.2
Haematopoietic and lymphoid	M07E	9.1
Haematopoietic and lymphoid	MC116	8.6
Haematopoietic and lymphoid	ME1	7.7
Haematopoietic and lymphoid	MEC1	9.1
Haematopoietic and lymphoid	MEC2	8.3
Haematopoietic and lymphoid	MEG01	8.6
Haematopoietic and lymphoid	MHHCALL2	9.4
Haematopoietic and lymphoid	MHHCALL3	9.5
Haematopoietic and lymphoid	MHHCALL4	9.6
Haematopoietic and lymphoid	MINO	8.8
Haematopoietic and lymphoid	MJ	8.1
Haematopoietic and lymphoid	MM1S	8.4
Haematopoietic and lymphoid	MOLM13	8.7
Haematopoietic and lymphoid	MOLM16	8.8
Haematopoietic and lymphoid	MOLM6	8.5
Haematopoietic and lymphoid	MOLP2	8.1
Haematopoietic and lymphoid	MOLP8	8.6
Haematopoietic and lymphoid	MOLT13	9.6
Haematopoietic and lymphoid	MOLT16	9.1
Haematopoietic and lymphoid	MOLT4	8.7
Haematopoietic and lymphoid	MONOMAC1	9.1
Haematopoietic and lymphoid	MONOMAC6	9.2
Haematopoietic and lymphoid	MOTN1	8.7
Haematopoietic and lymphoid	MUTZ5	8.9
Haematopoietic and lymphoid	MV411	8.5
Haematopoietic and lymphoid	NALM19	9.4
Haematopoietic and lymphoid	NALM1	9.5
Haematopoietic and lymphoid	NALM6	8.9
Haematopoietic and lymphoid	NAMALWA	8.5
Haematopoietic and lymphoid	NB4	9.3
Haematopoietic and lymphoid	NCIH929	7.8
Haematopoietic and lymphoid	NCO2	9
Haematopoietic and lymphoid	NOMO1	9.9
Haematopoietic and lymphoid	NUDHL1	8.9
Haematopoietic and lymphoid	NUDUL1	9.1
Haematopoietic and lymphoid	OCIAML2	9.2
Haematopoietic and lymphoid	OCIAML3	9.8
Haematopoietic and lymphoid	OCIAML5	9.1
Haematopoietic and lymphoid	OCILY10	8.6
Haematopoietic and lymphoid	OCILY19	9
Haematopoietic and lymphoid	OCILY3	8
Haematopoietic and lymphoid	OCIM1	9.5
Haematopoietic and lymphoid	OPM2	9.6
Haematopoietic and lymphoid	P12ICHIKAWA	9.2
Haematopoietic and lymphoid	P31FUJ	8.6
Haematopoietic and lymphoid	P3HR1	8.5
Haematopoietic and lymphoid	PCM6	8.8
Haematopoietic and lymphoid	PEER	8.9
Haematopoietic and lymphoid	PF382	9.7
Haematopoietic and lymphoid	PFEIFFER	9
Haematopoietic and lymphoid	PL21	9.5
Haematopoietic and lymphoid	RAJI	8.2
Haematopoietic and lymphoid	RCHACV	9
Haematopoietic and lymphoid	REC1	8.9
Haematopoietic and lymphoid	REH	8.9
Haematopoietic and lymphoid	RI1	8.1
Haematopoietic and lymphoid	RL	8.8
Haematopoietic and lymphoid	RPMI8226	7.9
Haematopoietic and lymphoid	RPMI8402	9.1
Haematopoietic and lymphoid	RS411	8.7
Haematopoietic and lymphoid	SEM	8.8
Haematopoietic and lymphoid	SET2	9.2
Haematopoietic and lymphoid	SIGM5	9.2
Haematopoietic and lymphoid	SKM1	8.8
Haematopoietic and lymphoid	SKMM2	8.6
Haematopoietic and lymphoid	SR786	8.7
Haematopoietic and lymphoid	ST486	8.5
Haematopoietic and lymphoid	SUDHL10	8.6
Haematopoietic and lymphoid	SUDHL1	8.6
Haematopoietic and lymphoid	SUDHL4	8.3
Haematopoietic and lymphoid	SUDHL5	8.6
Haematopoietic and lymphoid	SUDHL6	8.8
Haematopoietic and lymphoid	SUDHL8	8.5
Haematopoietic and lymphoid	SUPB15	9
Haematopoietic and lymphoid	SUPHD1	8.4
Haematopoietic and lymphoid	SUPM2	9
Haematopoietic and lymphoid	SUPT11	9.2
Haematopoietic and lymphoid	SUPT1	9
Haematopoietic and lymphoid	TALL1	9.5
Haematopoietic and lymphoid	TF1	9
Haematopoietic and lymphoid	THP1	8.7
Haematopoietic and lymphoid	TO175T	7.9
Haematopoietic and lymphoid	TOLEDO	9.3
Haematopoietic and lymphoid	U266B1	8.3
Haematopoietic and lymphoid	U937	8.3
Haematopoietic and lymphoid	UT7	9.8
Haematopoietic and lymphoid	WSUDLCL2	8.7
Kidney	769P	8
Kidney	786O	8.6
Kidney	A498	8.4
Kidney	A704	7.8
Kidney	ACHN	7.6
Kidney	BFTC909	8.5
Kidney	CAKI1	8
Kidney	CAKI2	7.7
Kidney	CAL54	8
Kidney	KMRC1	8.2
Kidney	KMRC20	8.2
Kidney	KMRC2	7.9
Kidney	KMRC3	8.4
Kidney	OSRC2	8.3
Kidney	RCC10RGB	8.7
Kidney	SNU1272	7.8
Kidney	SNU349	7.6
Kidney	TUHR10TKB	7.7
Kidney	TUHR14TKB	8
Kidney	TUHR4TKB	8.1
Kidney	VMRCRCW	8.3
Kidney	VMRCRCZ	8.9
Large intestine	C2BBE1	8.1
Large intestine	CCK81	8.5
Large intestine	CL11	8.4
Large intestine	CL14	9.6
Large intestine	CL34	8.6
Large intestine	CL40	8.1
Large intestine	COLO205	8.3
Large intestine	COLO320	8.4
Large intestine	COLO678	9.1
Large intestine	CW2	7.6
Large intestine	DLD1	7.7
Large intestine	GP2D	8.3
Large intestine	HCC56	7.9
Large intestine	HCT116	8
Large intestine	HCT15	7.7
Large intestine	HS675T	7.7
Large intestine	HS698T	7.8
Large intestine	HT115	9.1
Large intestine	HT29	8.4
Large intestine	HT55	8.6
Large intestine	KM12	8.1
Large intestine	LOVO	7.9
Large intestine	LS1034	8.2
Large intestine	LS123	8.6
Large intestine	LS180	8.5
Large intestine	LS411N	8.8
Large intestine	LS513	8.7
Large intestine	MDST8	7
Large intestine	NCIH508	8.7
Large intestine	NCIH716	8.7
Large intestine	NCIH747	8.6
Large intestine	OUMS23	9.1
Large intestine	RCM1	8
Large intestine	RKO	7.6
Large intestine	SKCO1	8.9
Large intestine	SNU1040	7.4
Large intestine	SNU1197	8.2
Large intestine	SNU175	8.5
Large intestine	SNU283	8
Large intestine	SNU407	8.6
Large intestine	SNU503	9.1
Large intestine	SNU61	8.2
Large intestine	SNU81	8.4
Large intestine	SNUC1	8.3
Large intestine	SNUC2A	7.9
Large intestine	SNUC4	7.8
Large intestine	SNUC5	8.2
Large intestine	SW1116	8.8
Large intestine	SW1417	8.6
Large intestine	SW1463	8.7
Large intestine	SW403	8.6
Large intestine	SW480	8
Large intestine	SW48	7.9
Large intestine	SW620	8.9
Large intestine	SW837	8.8
Large intestine	SW948	8.4
Large intestine	T84	7.3
Liver	ALEXANDERCELLS	7.5
Liver	C3A	8.2
Liver	HEP3B217	8.7
Liver	HEPG2	8.2
Liver	HLE	7.3
Liver	HLF	7.5
Liver	HUH1	7.6
Liver	HUH6	8.7
Liver	HUH7	8.9
Liver	JHH1	8.6
Liver	JHH2	8.1
Liver	JHH4	8.3
Liver	JHH5	8.4
Liver	JHH6	9.3
Liver	JHH7	8.7
Liver	LI7	8.7
Liver	PLCPRF5	7.3
Liver	SKHEP1	8.4
Liver	SNU182	8.9
Liver	SNU387	8.2
Liver	SNU398	8
Liver	SNU423	8.2
Liver	SNU449	7.8
Liver	SNU475	8.2
Liver	SNU761	8.3
Liver	SNU878	7.3
Liver	SNU886	8.2
Lung	A549	7.4
Lung	ABC1	9.4
Lung	BEN	9.1
Lung	CAL12T	8.6
Lung	CALU1	7.7
Lung	CALU3	8.4
Lung	CALU6	8.6
Lung	CHAGOK1	9.1
Lung	COLO668	8.9
Lung	COLO699	8.1
Lung	CORL105	8.2
Lung	CORL23	8.8
Lung	CORL24	9.2
Lung	CORL279	9.7
Lung	CORL311	9
Lung	CORL47	7.9
Lung	CORL51	8.9
Lung	CORL88	10.4
Lung	CORL95	9.4
Lung	CPCN	8.4
Lung	DMS114	8.2
Lung	DMS153	9.5
Lung	DMS273	8
Lung	DMS454	8.7
Lung	DMS53	7.8
Lung	DMS79	8.3
Lung	DV90	6.9
Lung	EBC1	8.2
Lung	EPLC272H	8.1
Lung	HARA	8.3
Lung	HCC1171	9.1
Lung	HCC1195	8
Lung	HCC15	8.4
Lung	HCC2279	7.4
Lung	HCC2935	9
Lung	HCC33	8.8
Lung	HCC366	8
Lung	HCC4006	8.3
Lung	HCC44	8
Lung	HCC78	8
Lung	HCC827	8.6
Lung	HCC95	8.5
Lung	HLC1	8.2
Lung	HLFA	7.7
Lung	HS229T	8
Lung	HS618T	7.8
Lung	IALM	8.4
Lung	KNS62	8.4
Lung	LC1F	8.4
Lung	LC1SQSF	8.6
Lung	LCLC103H	9.5
Lung	LCLC97TM1	8.2
Lung	LK2	9.1
Lung	LOUNH91	8.3
Lung	LU65	8.3
Lung	LU99	8.7
Lung	LUDLU1	9.3
Lung	LXF289	9.1
Lung	MORCPR	9.6
Lung	NCIH1048	8.2
Lung	NCIH1092	9.1
Lung	NCIH1105	9.5
Lung	NCIH1155	8.5
Lung	NCIH1184	9.5
Lung	NCIH1299	8
Lung	NCIH1339	8.5
Lung	NCIH1341	8.7
Lung	NCIH1355	8.3
Lung	NCIH1373	8.2
Lung	NCIH1385	7.9
Lung	NCIH1395	8.7
Lung	NCIH1435	9.8
Lung	NCIH1436	8.8
Lung	NCIH1437	8.8
Lung	NCIH146	8.3
Lung	NCIH1563	8.1
Lung	NCIH1568	8.2
Lung	NCIH1573	8.8
Lung	NCIH1581	9.7
Lung	NCIH1618	9.1
Lung	NCIH1623	8.5
Lung	NCIH1648	8.1
Lung	NCIH1650	9.2
Lung	NCIH1651	8.6
Lung	NCIH1666	8.2
Lung	NCIH1693	8.2
Lung	NCIH1694	8.9
Lung	NCIH1703	9.4
Lung	NCIH1734	8.9
Lung	NCIH1755	8.1
Lung	NCIH1781	9
Lung	NCIH1792	7.8
Lung	NCIH1793	8.2
Lung	NCIH1836	8.6
Lung	NCIH1838	8.6
Lung	NCIH1869	9.6
Lung	NCIH1876	10.3
Lung	NCIH1915	7.2
Lung	NCIH1930	9.2
Lung	NCIH1944	9.1
Lung	NCIH1963	8.9
Lung	NCIH196	9.3
Lung	NCIH1975	8.3
Lung	NCIH2009	8.6
Lung	NCIH2023	8.1
Lung	NCIH2029	9.2
Lung	NCIH2030	8.3
Lung	NCIH2066	9.7
Lung	NCIH2081	10
Lung	NCIH2085	9.2
Lung	NCIH2087	8.3
Lung	NCIH209	9.3
Lung	NCIH2106	7.9
Lung	NCIH2110	9.9
Lung	NCIH211	8.7
Lung	NCIH2122	8.5
Lung	NCIH2126	9.5
Lung	NCIH2141	9.7
Lung	NCIH2170	8.5
Lung	NCIH2171	8.9
Lung	NCIH2172	9.2
Lung	NCIH2196	8.5
Lung	NCIH2227	8.8
Lung	NCIH2228	8.4
Lung	NCIH226	8.3
Lung	NCIH2286	8.7
Lung	NCIH2291	8.6
Lung	NCIH2342	8.8
Lung	NCIH2347	8.4
Lung	NCIH23	9.5
Lung	NCIH2405	8.2
Lung	NCIH2444	8.1
Lung	NCIH292	8.9
Lung	NCIH322	8.4
Lung	NCIH3255	8.9
Lung	NCIH358	8.4
Lung	NCIH441	8.5
Lung	NCIH446	9.1
Lung	NCIH460	8.1
Lung	NCIH510	9.1
Lung	NCIH520	8.6
Lung	NCIH522	8
Lung	NCIH524	9.1
Lung	NCIH526	9
Lung	NCIH596	9.8
Lung	NCIH647	7.7
Lung	NCIH650	9.4
Lung	NCIH661	8.8
Lung	NCIH69	8.7
Lung	NCIH727	8.1
Lung	NCIH810	9.1
Lung	NCIH82	8.7
Lung	NCIH838	8.7
Lung	NCIH841	8.5
Lung	NCIH854	9
Lung	NCIH889	8.7
Lung	PC14	9.5
Lung	RERFLCAD1	8.4
Lung	RERFLCAD2	8.5
Lung	RERFLCAI	8
Lung	RERFLCKJ	9.3
Lung	RERFLCMS	7.8
Lung	RERFLCSQ1	8.8
Lung	SBC5	8.2
Lung	SCLC21H	9.1
Lung	SHP77	9.1
Lung	SKLU1	7.1
Lung	SKMES1	8.5
Lung	SQ1	7.5
Lung	SW1271	9.1
Lung	SW1573	8.8
Lung	SW900	8.6
Lung	VMRCLCD	9
Lung	VMRCLCP	8.4
Oesophagus	COLO680N	9.5
Oesophagus	ECGI10	8.8
Oesophagus	KYSE140	9.2
Oesophagus	KYSE150	8
Oesophagus	KYSE180	8.7
Oesophagus	KYSE270	9.1
Oesophagus	KYSE30	9.2
Oesophagus	KYSE410	8.6
Oesophagus	KYSE450	8.6
Oesophagus	KYSE510	8.8
Oesophagus	KYSE520	8.1
Oesophagus	KYSE70	9.1
Oesophagus	OE19	7.4
Oesophagus	OE33	8.9
Oesophagus	TE10	9.7
Oesophagus	TE11	8.7
Oesophagus	TE14	9.1
Oesophagus	TE15	9.3
Oesophagus	TE1	9.4
Oesophagus	TE4	9
Oesophagus	TE5	8.9
Oesophagus	TE6	8.7
Oesophagus	TE8	9.4
Oesophagus	TE9	8.6
Oesophagus	TT	9.1
Ovary	59M	7.9
Ovary	A2780	8.6
Ovary	CAOV3	8.7
Ovary	CAOV4	8.8
Ovary	COLO704	8.7
Ovary	COV318	8.4
Ovary	COV362	8.5
Ovary	COV434	8
Ovary	COV504	8.5
Ovary	COV644	9.1
Ovary	EFO21	7.7
Ovary	EFO27	8
Ovary	ES2	8.2
Ovary	FUOV1	8.3
Ovary	HEYA8	8.5
Ovary	HS571T	7.5
Ovary	IGROV1	8
Ovary	JHOC5	8.4
Ovary	JHOM1	9.2
Ovary	JHOM2B	8.8
Ovary	JHOS2	7.8
Ovary	JHOS4	8.2
Ovary	KURAMOCHI	9.5
Ovary	MCAS	9.3
Ovary	NIHOVCAR3	8.5
Ovary	OAW28	9.3
Ovary	OAW42	8.1
Ovary	OC314	7.7
Ovary	OC316	7.6
Ovary	ONCODG1	8.6
Ovary	OV56	8
Ovary	OV7	7.9
Ovary	OV90	8.3
Ovary	OVCAR4	8
Ovary	OVCAR8	8.9
Ovary	OVISE	7.3
Ovary	OVK18	6.8
Ovary	OVKATE	8.8
Ovary	OVMANA	8.7
Ovary	OVSAHO	8.3
Ovary	OVTOKO	7.7
Ovary	RMGI	7.4
Ovary	RMUGS	7.6
Ovary	SKOV3	8.2
Ovary	SNU119	8.5
Ovary	SNU840	8.5
Ovary	SNU8	8.3
Ovary	TOV112D	7.6
Ovary	TOV21G	7.8
Ovary	TYKNU	8
Pancreas	ASPC1	8.5
Pancreas	BXPC3	8.3
Pancreas	CAPAN1	9.1
Pancreas	CAPAN2	8.5
Pancreas	CFPAC1	8.6
Pancreas	DANG	8.5
Pancreas	HPAC	10.4
Pancreas	HPAFII	8
Pancreas	HS766T	8.6
Pancreas	HUPT3	7.9
Pancreas	HUPT4	8.2
Pancreas	KCIMOH1	9.8
Pancreas	KLM1	7.2
Pancreas	KP2	9.3
Pancreas	KP3	8.2
Pancreas	KP4	8.9
Pancreas	L33	8.9
Pancreas	MIAPACA2	8.6
Pancreas	PANC0203	7.5
Pancreas	PANC0213	9
Pancreas	PANC0327	8.4
Pancreas	PANC0403	8.2
Pancreas	PANC0504	8.2
Pancreas	PANC0813	7.9
Pancreas	PANC1005	8.4
Pancreas	PANC1	8.1
Pancreas	PATU8902	8.5
Pancreas	PATU8988S	8.3
Pancreas	PATU8988T	7.8
Pancreas	PK1	8.4
Pancreas	PK45H	10.1
Pancreas	PK59	9.3
Pancreas	PL45	8.4
Pancreas	PSN1	7.7
Pancreas	QGP1	8.9
Pancreas	SNU213	8.3
Pancreas	SNU324	7.8
Pancreas	SNU410	8.2
Pancreas	SU8686	8.5
Pancreas	SUIT2	8.5
Pancreas	SW1990	7
Pancreas	T3M4	9.3
Pancreas	TCCPAN2	8.1
Pancreas	YAPC	8.4
Pleura	ACCMESO1	8
Pleura	DM3	7.3
Pleura	ISTMES1	8.3
Pleura	ISTMES2	8.3
Pleura	JL1	8.6
Pleura	MPP89	8.7
Pleura	MSTO211H	8.3
Pleura	NCIH2052	9.1
Pleura	NCIH2452	8.4
Pleura	NCIH28	8.5
Prostate	22RV1	8
Prostate	DU145	8.7
Prostate	LNCAPCLONEFGC	7.5
Prostate	MDAPCA2B	7.8
Prostate	NCIH660	8.9
Prostate	PC3	7.6
Prostate	VCAP	8.6
Salivary gland	A253	9.7
Salivary gland	YD15	8.7
Skin	A101D	7.9
Skin	A2058	8.2
Skin	A375	7.5
Skin	C32	7.9
Skin	CHL1	8.1
Skin	CJM	9.1
Skin	COLO679	7.7
Skin	COLO741	7.8
Skin	COLO783	7.6
Skin	COLO792	6.2
Skin	COLO800	9.1
Skin	COLO818	8.6
Skin	COLO829	7.4
Skin	COLO849	7.4
Skin	G361	8.4
Skin	GRM	6.7
Skin	HMCB	8.3
Skin	HS294T	7.9
Skin	HS600T	7.6
Skin	HS688AT	7.7
Skin	HS695T	8.5
Skin	HS839T	7.8
Skin	HS852T	10.2
Skin	HS895T	7.8
Skin	HS934T	8.2
Skin	HS936T	7.2
Skin	HS939T	7.9
Skin	HS940T	7.9
Skin	HS944T	7.6
Skin	HT144	8.2
Skin	IGR1	8.8
Skin	IGR37	6.8
Skin	IGR39	8.9
Skin	IPC298	7.5
Skin	K029AX	8
Skin	LOXIMVI	8.1
Skin	MALME3M	7.6
Skin	MDAMB435S	8.5
Skin	MELHO	8.2
Skin	MELJUSO	7.5
Skin	MEWO	8.5
Skin	RPMI7951	8.2
Skin	RVH421	7.9
Skin	SH4	7.8
Skin	SKMEL1	8.2
Skin	SKMEL24	8.7
Skin	SKMEL28	8
Skin	SKMEL2	6.8
Skin	SKMEL30	7.9
Skin	SKMEL31	8.1
Skin	SKMEL3	7.6
Skin	SKMEL5	8
Skin	UACC257	7
Skin	UACC62	7.9
Skin	WM115	8.2
Skin	WM1799	9.1
Skin	WM2664	7.6
Skin	WM793	7.9
Skin	WM88	8.6
Skin	WM983B	8.4
Small intestine	HUTU80	8.5
Soft tissue	A204	7.7
Soft tissue	G401	8.3
Soft tissue	G402	7.8
Soft tissue	GCT	8.2
Soft tissue	HS729	9.3
Soft tissue	HT1080	8.1
Soft tissue	KYM1	8.5
Soft tissue	MESSA	8.2
Soft tissue	RD	8.2
Soft tissue	RH30	8.1
Soft tissue	RH41	8.6
Soft tissue	RKN	8.8
Soft tissue	S117	7.6
Soft tissue	SJRH30	8.9
Soft tissue	SKLMS1	8.1
Soft tissue	SKUT1	7.9
Soft tissue	TE125T	7.9
Soft tissue	TE159T	7.6
Soft tissue	TE441T	8.4
Soft tissue	TE617T	8
Stomach	2313287	8.5
Stomach	AGS	8.5
Stomach	AZ521	8.3
Stomach	ECC10	9.4
Stomach	ECC12	9.4
Stomach	FU97	8.4
Stomach	GCIY	8.4
Stomach	GSS	9.3
Stomach	GSU	8.3
Stomach	HGC27	8.8
Stomach	HS746T	8.1
Stomach	HUG1N	8.4
Stomach	IM95	7.8
Stomach	KATOIII	7.7
Stomach	KE39	8.3
Stomach	LMSU	8.3
Stomach	MKN1	9.2
Stomach	MKN45	8.6
Stomach	MKN74	8.7
Stomach	MKN7	9
Stomach	NCCSTCK140	8.8
Stomach	NCIN87	7.8
Stomach	NUGC2	8.5
Stomach	NUGC3	8.5
Stomach	NUGC4	8.4
Stomach	OCUM1	8.1
Stomach	RERFGC1B	8.4
Stomach	SH10TC	8.2
Stomach	SNU16	8.7
Stomach	SNU1	7.7
Stomach	SNU216	8.7
Stomach	SNU520	7.8
Stomach	SNU5	7.5
Stomach	SNU601	7.9
Stomach	SNU620	8.3
Stomach	SNU668	8.4
Stomach	SNU719	8.1
Stomach	TGBC11TKB	8.7
Thyroid	8305C	7.7
Thyroid	8505C	8.6
Thyroid	BCPAP	8.8
Thyroid	BHT101	8.5
Thyroid	CAL62	8.8
Thyroid	CGTHW1	8
Thyroid	FTC133	7.8
Thyroid	FTC238	7.6
Thyroid	ML1	8.6
Thyroid	SW579	7.7
Thyroid	TT2609C02	7.9
Thyroid	TT	8.6
Upper aerodigestive tract	BHY	10.1
Upper aerodigestive tract	BICR16	8
Upper aerodigestive tract	BICR18	8.3
Upper aerodigestive tract	BICR22	8.4
Upper aerodigestive tract	BICR31	8.5
Upper aerodigestive tract	BICR56	8.3
Upper aerodigestive tract	BICR6	8.8
Upper aerodigestive tract	CAL27	8.4
Upper aerodigestive tract	CAL33	8
Upper aerodigestive tract	DETROIT562	9.7
Upper aerodigestive tract	FADU	9.3
Upper aerodigestive tract	HS840T	7.6
Upper aerodigestive tract	HSC2	8.7
Upper aerodigestive tract	HSC3	8.8
Upper aerodigestive tract	HSC4	9.6
Upper aerodigestive tract	PECAPJ15	8.8
Upper aerodigestive tract	PECAPJ34CLONEC12	8.2
Upper aerodigestive tract	PECAPJ41CLONED2	8.9
Upper aerodigestive tract	PECAPJ49	8.8
Upper aerodigestive tract	SCC15	8.7
Upper aerodigestive tract	SCC25	8.7
Upper aerodigestive tract	SCC4	9.5
Upper aerodigestive tract	SCC9	8.7
Upper aerodigestive tract	SNU1076	8.5
Upper aerodigestive tract	SNU1214	8.3
Upper aerodigestive tract	SNU46	8.4
Upper aerodigestive tract	SNU899	8.3
Upper aerodigestive tract	YD10B	8.4
Upper aerodigestive tract	YD38	8.5
Upper aerodigestive tract	YD8	8.6
Urinary tract	5637	7.8
Urinary tract	639V	9.5
Urinary tract	647V	9.4
Urinary tract	BC3C	8.2
Urinary tract	BFTC905	8.4
Urinary tract	CAL29	8.7
Urinary tract	HS172T	8
Urinary tract	HT1197	8.8
Urinary tract	HT1376	9.3
Urinary tract	J82	8.3
Urinary tract	JMSU1	8.5
Urinary tract	KMBC2	8.5
Urinary tract	KU1919	8.7
Urinary tract	RT11284	8.4
Urinary tract	RT112	7.8
Urinary tract	RT4	8.1
Urinary tract	SCABER	8.4
Urinary tract	SW1710	8.5
Urinary tract	SW780	8.9
Urinary tract	T24	8.4
Urinary tract	TCCSUP	9.2
Urinary tract	UMUC1	6.9
Urinary tract	UMUC3	8.5
Urinary tract	VMCUB1	9.3

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	20.8
Adrenal gland	21.3
Appendix	33.9
Bone marrow	22
Breast	30.9
Cerebral cortex	23.5
Cervix, uterine	31.3
Colon	21.6
Duodenum	15.1
Endometrium	36.3
Epididymis	19
Esophagus	23.3
Fallopian tube	26.7
Gallbladder	35.2
Heart muscle	9.5
Kidney	19.2
Liver	9.7
Lung	31.7
Lymph node	36.6
Ovary	35.2
Pancreas	4.7
Parathyroid gland	55.9
Placenta	31.4
Prostate	30.2
Rectum	21.5
Salivary gland	10.2
Seminal vesicle	26.8
Skeletal muscle	5.5
Skin	38.2
Small intestine	22.3
Smooth muscle	24.2
Spleen	37
Stomach	21.2
Testis	40.6
Thyroid gland	47.7
Tonsil	26.9
Urinary bladder	23.8

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
25963978	Overexpression	Non-Small Cell Lung Cancer	Immunohistochemical analysis showed that high expression of NIPBL was strongly correlated with poor prognosis, tumor differentiation, and lymph node metastasis.

Summary
Symbol	NIPBL
Name	NIPBL, cohesin loading factor
Aliases	IDN3; DKFZp434L1319; FLJ11203; FLJ12597; FLJ13354; FLJ13648; Scc2; sister chromatid cohesion 2 homolog (yeas ......
Location	5p13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.617	1.1e-43	8.9	43.1	48	Gain
BRCA	Breast invasive carcinoma	1075	0.386	1.37e-39	9.4	57.6	33	Neutral
CESC	Cervical and endocervical cancers	292	0.687	4.52e-42	3.4	55.5	41.1	Gain
COAD	Colon adenocarcinoma	449	0.322	2.93e-12	10.9	69.9	19.2	Neutral
ESCA	Esophageal carcinoma	183	0.687	6.22e-27	19.7	31.1	49.2	Gain
GBM	Glioblastoma multiforme	147	0.27	0.000925	8.8	83.7	7.5	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.493	7.17e-33	6.4	51	42.6	Gain
KIRC	Kidney renal clear cell carcinoma	525	0.248	8.67e-09	1.1	66.7	32.2	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.276	1.99e-06	2.1	85.8	12.2	Neutral
LAML	Acute Myeloid Leukemia	166	-0.058	0.455	0.6	98.8	0.6	Neutral
LGG	Brain Lower Grade Glioma	513	0.154	0.000471	6.2	91.4	2.3	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.37	3.06e-13	4.4	55.8	39.8	Gain
LUAD	Lung adenocarcinoma	512	0.613	3.23e-54	5.3	35.2	59.6	Gain
LUSC	Lung squamous cell carcinoma	498	0.695	3.92e-73	4.4	21.3	74.3	Gain
OV	Ovarian serous cystadenocarcinoma	300	0.57	2.95e-27	11.7	43.3	45	Gain
PAAD	Pancreatic adenocarcinoma	177	0.287	0.000111	5.1	80.2	14.7	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.422	2.33e-08	3.1	90.1	6.8	Neutral
PRAD	Prostate adenocarcinoma	491	0.257	7.6e-09	2.4	91	6.5	Neutral
READ	Rectum adenocarcinoma	164	0.36	2.21e-06	12.8	62.8	24.4	Neutral
SARC	Sarcoma	255	0.557	3.41e-22	6.7	47.8	45.5	Gain
SKCM	Skin Cutaneous Melanoma	367	0.383	2.7e-14	18.8	55	26.2	Neutral
STAD	Stomach adenocarcinoma	413	0.667	1.42e-54	12.1	58.1	29.8	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.225	0.00553	68.7	27.3	4	Loss
THCA	Thyroid carcinoma	497	0.104	0.0208	0	95.6	4.4	Neutral
THYM	Thymoma	119	-0.057	0.541	0.8	89.9	9.2	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.456	5.83e-29	7.1	79	14	Neutral

Summary
Symbol	NIPBL
Name	NIPBL, cohesin loading factor
Aliases	IDN3; DKFZp434L1319; FLJ11203; FLJ12597; FLJ13354; FLJ13648; Scc2; sister chromatid cohesion 2 homolog (yeas ......
Location	5p13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.464	0	17	408	0.008	0.00041	NS/NA
BRCA	Breast invasive carcinoma	-0.377	0	83	785	0.001	3.36e-07	NS/NA
CESC	Cervical and endocervical cancers	-0.339	1.28e-09	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.165	0.00339	19	297	0.001	0.00289	NS/NA
ESCA	Esophageal carcinoma	-0.512	0	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.218	0.0812	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.45	0	20	522	0.003	1.43e-05	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.238	8.65e-06	24	319	0.008	8.73e-06	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.344	1.37e-09	23	275	0.024	4.52e-22	NS/NA
LAML	Acute Myeloid Leukemia	-0.178	0.0204	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.297	4.1e-12	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.175	0.000349	41	373	0.009	2.04e-19	NS/NA
LUAD	Lung adenocarcinoma	-0.205	6.34e-06	21	456	-0.013	0.0426	NS/NA
LUSC	Lung squamous cell carcinoma	-0.414	0	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.85	0.00607	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.439	7.42e-10	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.138	0.0588	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.47	0	35	498	0.018	3.38e-30	NS/NA
READ	Rectum adenocarcinoma	-0.177	0.0774	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.416	2.69e-12	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.388	0	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.186	0.000318	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.257	0.00124	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.162	0.000127	50	509	0.001	0.017	NS/NA
THYM	Thymoma	-0.135	0.137	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.242	1.33e-07	34	431	0	2.61e-07	NS/NA

Summary
Symbol	NIPBL
Name	NIPBL, cohesin loading factor
Aliases	IDN3; DKFZp434L1319; FLJ11203; FLJ12597; FLJ13354; FLJ13648; Scc2; sister chromatid cohesion 2 homolog (yeas ......
Location	5p13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	3	High
Appendix	2	Medium
Bone marrow	2	Medium
Breast	2	Medium
Bronchus	2	Medium
Caudate	2	Medium
Cerebellum	2	Medium
Cerebral cortex	1	Low
Cervix, uterine	1	Low
Colon	3	High
Duodenum	2	Medium
Endometrium	2	Medium
Epididymis	1	Low
Esophagus	2	Medium
Fallopian tube	2	Medium
Gallbladder	2	Medium
Heart muscle	2	Medium
Hippocampus	2	Medium
Kidney	2	Medium
Liver	0	Not detected
Lung	1	Low
Lymph node	0	Not detected
Nasopharynx	2	Medium
Oral mucosa	2	Medium
Ovary	2	Medium
Pancreas	2	Medium
Parathyroid gland	0	Not detected
Placenta	3	High
Prostate	0	Not detected
Rectum	2	Medium
Salivary gland	2	Medium
Seminal vesicle	2	Medium
Skeletal muscle	1	Low
Skin	3	High
Small intestine	2	Medium
Smooth muscle	2	Medium
Soft tissue	2	Medium
Spleen	0	Not detected
Stomach	3	High
Testis	3	High
Thyroid gland	3	High
Tonsil	2	Medium
Urinary bladder	2	Medium
Vagina	3	High

Summary
Symbol	NIPBL
Name	NIPBL, cohesin loading factor
Aliases	IDN3; DKFZp434L1319; FLJ11203; FLJ12597; FLJ13354; FLJ13648; Scc2; sister chromatid cohesion 2 homolog (yeas ......
Location	5p13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.704	NS	24476821
BRCA	Breast invasive carcinoma	521	1.22e-05	Significant	23000897
COAD	Colon adenocarcinoma	149	0.111	NS	22810696
GBM	Glioblastoma multiforme	157	0.00494	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	0.00635	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.341	NS	26536169
LGG	Brain Lower Grade Glioma	513	5.48e-07	Significant	26824661
LUAD	Lung adenocarcinoma	230	0.894	NS	25079552
LUSC	Lung squamous cell carcinoma	178	0.097	NS	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.101	NS	21720365
PRAD	Prostate adenocarcinoma	333	0.000368	Significant	26544944
READ	Rectum adenocarcinoma	67	0.167	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.614	NS	26091043
STAD	Stomach adenocarcinoma	277	0.011	Significant	25079317
THCA	Thyroid carcinoma	391	0.759	NS	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.00373	Significant	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	0.872	0.508	NS
BRCA	Breast invasive carcinoma	1079	1.569	0.0605	NS
CESC	Cervical and endocervical cancers	291	1.058	0.875	NS
COAD	Colon adenocarcinoma	439	1.149	0.615	NS
ESCA	Esophageal carcinoma	184	0.89	0.729	NS
GBM	Glioblastoma multiforme	158	0.805	0.409	NS
HNSC	Head and Neck squamous cell carcinoma	518	0.76	0.148	NS
KIRC	Kidney renal clear cell carcinoma	531	0.465	0.000708	Longer
KIRP	Kidney renal papillary cell carcinoma	287	1.447	0.384	NS
LAML	Acute Myeloid Leukemia	149	0.742	0.331	NS
LGG	Brain Lower Grade Glioma	511	0.928	0.765	NS
LIHC	Liver hepatocellular carcinoma	365	1.177	0.493	NS
LUAD	Lung adenocarcinoma	502	0.897	0.608	NS
LUSC	Lung squamous cell carcinoma	494	0.992	0.967	NS
OV	Ovarian serous cystadenocarcinoma	303	1.07	0.745	NS
PAAD	Pancreatic adenocarcinoma	177	1.225	0.479	NS
PCPG	Pheochromocytoma and Paraganglioma	179	623357095.592	0.0408	Shorter
PRAD	Prostate adenocarcinoma	497	2.449	0.515	NS
READ	Rectum adenocarcinoma	159	0.46	0.195	NS
SARC	Sarcoma	259	1.077	0.801	NS
SKCM	Skin Cutaneous Melanoma	459	0.681	0.0493	Longer
STAD	Stomach adenocarcinoma	388	0.869	0.525	NS
TGCT	Testicular Germ Cell Tumors	134	1.093	0.95	NS
THCA	Thyroid carcinoma	500	1.801	0.399	NS
THYM	Thymoma	119	0.257	0.19	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	2.328	0.00442	Shorter

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	-0.103	0.038	Lower
BRCA	Breast invasive carcinoma	1071	-0.022	0.471	NS
CESC	Cervical and endocervical cancers	167	-0.073	0.348	NS
COAD	Colon adenocarcinoma	445	0.022	0.647	NS
ESCA	Esophageal carcinoma	162	0.039	0.624	NS
HNSC	Head and Neck squamous cell carcinoma	448	-0.021	0.664	NS
KIRC	Kidney renal clear cell carcinoma	531	-0.092	0.0332	Lower
KIRP	Kidney renal papillary cell carcinoma	260	-0.012	0.849	NS
LIHC	Liver hepatocellular carcinoma	347	0.071	0.185	NS
LUAD	Lung adenocarcinoma	507	0.01	0.826	NS
LUSC	Lung squamous cell carcinoma	497	0.004	0.922	NS
OV	Ovarian serous cystadenocarcinoma	302	-0.076	0.185	NS
PAAD	Pancreatic adenocarcinoma	176	0.015	0.839	NS
READ	Rectum adenocarcinoma	156	0.05	0.534	NS
SKCM	Skin Cutaneous Melanoma	410	-0.097	0.0506	NS
STAD	Stomach adenocarcinoma	392	0.084	0.0982	NS
TGCT	Testicular Germ Cell Tumors	81	-0.406	0.000173	Lower
THCA	Thyroid carcinoma	499	-0.042	0.347	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.055	0.219	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	0.076	0.209	NS
HNSC	Head and Neck squamous cell carcinoma	498	0.045	0.319	NS
KIRC	Kidney renal clear cell carcinoma	525	-0.111	0.0109	Lower
LGG	Brain Lower Grade Glioma	514	0	0.993	NS
LIHC	Liver hepatocellular carcinoma	366	0.043	0.411	NS
OV	Ovarian serous cystadenocarcinoma	296	-0.045	0.444	NS
PAAD	Pancreatic adenocarcinoma	176	-0.015	0.843	NS
STAD	Stomach adenocarcinoma	406	-0.071	0.152	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.215	5.41e-07	Higher

Summary
Symbol	NIPBL
Name	NIPBL, cohesin loading factor
Aliases	IDN3; DKFZp434L1319; FLJ11203; FLJ12597; FLJ13354; FLJ13648; Scc2; sister chromatid cohesion 2 homolog (yeas ......
Location	5p13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	NIPBL
Name	NIPBL, cohesin loading factor
Aliases	IDN3; DKFZp434L1319; FLJ11203; FLJ12597; FLJ13354; FLJ13648; Scc2; sister chromatid cohesion 2 homolog (yeas ......
Location	5p13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for NIPBL.

Summary
Symbol	NIPBL
Name	NIPBL, cohesin loading factor
Aliases	IDN3; DKFZp434L1319; FLJ11203; FLJ12597; FLJ13354; FLJ13648; Scc2; sister chromatid cohesion 2 homolog (yeas ......
Location	5p13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
25963978	Non-Small Cell Lung Cancer	downstream	STAT3	regulation	NIPBL bound to the promoter region of the STAT3 gene, directly regulating the expression of STAT3.