CR2Cancer

Summary
Symbol	PHC1
Name	polyhomeotic homolog 1
Aliases	HPH1; RAE28; EDR1; early development regulator 1 (homolog of polyhomeotic 1); polyhomeotic-like 1 (Drosophil ......
Location	12p13.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

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Domain

PF00536 SAM domain (Sterile alpha motif)

Function

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Required for proper control of cellular levels of GMNN expression.

Classification

Class	Modification	Substrate	Product	PubMed
Polycomb group (PcG) protein	#	#	#	16024804

> Gene Ontology [ TOP ]
Biological Process	GO:0016570 histone modification GO:0016574 histone ubiquitination GO:0016925 protein sumoylation GO:0018205 peptidyl-lysine modification
Molecular Function	-
Cellular Component	GO:0000151 ubiquitin ligase complex GO:0000152 nuclear ubiquitin ligase complex GO:0031519 PcG protein complex GO:0035102 PRC1 complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-2559583: Cellular Senescence R-HSA-2262752: Cellular responses to stress R-HSA-392499: Metabolism of proteins R-HSA-2559580: Oxidative Stress Induced Senescence R-HSA-597592: Post-translational protein modification R-HSA-3108232: SUMO E3 ligases SUMOylate target proteins R-HSA-2990846: SUMOylation R-HSA-3108214: SUMOylation of DNA damage response and repair proteins R-HSA-4570464: SUMOylation of RNA binding proteins

> KEGG and Reactome Pathway

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KEGG

Reactome

R-HSA-2559583: Cellular Senescence
R-HSA-2262752: Cellular responses to stress
R-HSA-392499: Metabolism of proteins
R-HSA-2559580: Oxidative Stress Induced Senescence
R-HSA-597592: Post-translational protein modification
R-HSA-3108232: SUMO E3 ligases SUMOylate target proteins
R-HSA-2990846: SUMOylation
R-HSA-3108214: SUMOylation of DNA damage response and repair proteins
R-HSA-4570464: SUMOylation of RNA binding proteins

Summary
Symbol	PHC1
Name	polyhomeotic homolog 1
Aliases	HPH1; RAE28; EDR1; early development regulator 1 (homolog of polyhomeotic 1); polyhomeotic-like 1 (Drosophil ......
Location	12p13.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM4594767	c.369C>T	p.P123P	Substitution - coding silent	Upper_aerodigestive_tract
COSM5483816	c.2890T>C	p.S964P	Substitution - Missense	Large_intestine
COSM944335	c.748G>T	p.V250L	Substitution - Missense	Kidney
COSM1364810	c.2518delA	p.M842fs*1	Deletion - Frameshift	Large_intestine
COSM3931755	c.1789C>A	p.P597T	Substitution - Missense	Urinary_tract
COSM4045328	c.1272G>A	p.A424A	Substitution - coding silent	Stomach
COSM3466326	c.906G>A	p.G302G	Substitution - coding silent	Skin
COSM3466328	c.1956C>T	p.V652V	Substitution - coding silent	Skin
COSM378145	c.2156T>C	p.M719T	Substitution - Missense	Lung
COSM5929436	c.2810C>T	p.P937L	Substitution - Missense	Skin
COSM944342	c.2610T>G	p.I870M	Substitution - Missense	Endometrium
COSM32761	c.1838C>G	p.S613*	Substitution - Nonsense	Breast
COSM4575778	c.217G>A	p.V73I	Substitution - Missense	Adrenal_gland
COSM1747289	c.2660A>C	p.N887T	Substitution - Missense	Urinary_tract
COSM695474	c.1083C>G	p.P361P	Substitution - coding silent	Lung
COSM404673	c.481G>T	p.V161L	Substitution - Missense	Lung
COSM4923844	c.1067C>A	p.T356K	Substitution - Missense	Liver
COSM1299951	c.345C>G	p.S115R	Substitution - Missense	Urinary_tract
COSM5510575	c.2123C>T	p.P708L	Substitution - Missense	Biliary_tract
COSM944336	c.1287G>A	p.Q429Q	Substitution - coding silent	Large_intestine
COSM4575779	c.236C>G	p.A79G	Substitution - Missense	Bone
COSM944340	c.2385G>A	p.A795A	Substitution - coding silent	Endometrium
COSM1606741	c.1165C>T	p.Q389*	Substitution - Nonsense	Liver
COSM1606741	c.1165C>T	p.Q389*	Substitution - Nonsense	Upper_aerodigestive_tract
COSM3931756	c.2666G>T	p.S889I	Substitution - Missense	Urinary_tract
COSM382662	c.1123C>A	p.Q375K	Substitution - Missense	Lung
COSM1162342	c.918A>G	p.R306R	Substitution - coding silent	Biliary_tract
COSM944337	c.1383T>G	p.P461P	Substitution - coding silent	Endometrium
COSM1162342	c.918A>G	p.R306R	Substitution - coding silent	Upper_aerodigestive_tract
COSM2044754	c.347G>A	p.R116Q	Substitution - Missense	Stomach
COSM283983	c.225+5G>A	p.?	Unknown	Large_intestine
COSM1262026	c.487C>T	p.R163*	Substitution - Nonsense	Stomach
COSM1262027	c.2013A>C	p.K671N	Substitution - Missense	Stomach
COSM1220318	c.2419G>A	p.A807T	Substitution - Missense	Large_intestine
COSM5446146	c.1287_1289delGCA	p.Q439delQ	Deletion - In frame	Thyroid
COSM4386136	c.1028G>A	p.G343E	Substitution - Missense	Large_intestine
COSM269876	c.331G>A	p.A111T	Substitution - Missense	Large_intestine
COSM5811398	c.1047G>A	p.V349V	Substitution - coding silent	Liver
COSM3936196	c.2331G>A	p.Q777Q	Substitution - coding silent	Oesophagus
COSM3417254	c.157T>C	p.F53L	Substitution - Missense	Large_intestine
COSM4045329	c.2404T>C	p.Y802H	Substitution - Missense	Stomach
COSM5888185	c.115-5C>T	p.?	Unknown	Upper_aerodigestive_tract
COSM3466324	c.454C>G	p.R152G	Substitution - Missense	Skin
COSM944338	c.1893G>A	p.P631P	Substitution - coding silent	Endometrium
COSM5805596	c.570G>T	p.V190V	Substitution - coding silent	Liver
COSM369843	c.1105+1G>T	p.?	Unknown	Lung
COSM1364808	c.2400C>T	p.C800C	Substitution - coding silent	Large_intestine
COSM6000675	c.2023G>T	p.E675*	Substitution - Nonsense	Prostate
COSM459347	c.2600G>A	p.R867H	Substitution - Missense	Cervix
COSM431974	c.1254T>C	p.A418A	Substitution - coding silent	Breast
COSM4889429	c.575C>A	p.S192Y	Substitution - Missense	Upper_aerodigestive_tract
COSM2044775	c.1852C>G	p.Q618E	Substitution - Missense	Large_intestine
COSM459347	c.2600G>A	p.R867H	Substitution - Missense	Large_intestine
COSM944340	c.2385G>A	p.A795A	Substitution - coding silent	Oesophagus
COSM1220319	c.157T>G	p.F53V	Substitution - Missense	Large_intestine
COSM1728783	c.2282C>T	p.S761F	Substitution - Missense	Liver
COSM2044789	c.2425G>A	p.A809T	Substitution - Missense	Large_intestine
COSM5823309	c.2080C>G	p.P694A	Substitution - Missense	Liver
COSM4489665	c.350C>T	p.S117F	Substitution - Missense	Skin
COSM944335	c.748G>T	p.V250L	Substitution - Missense	Endometrium
COSM5929437	c.2809C>T	p.P937S	Substitution - Missense	Skin
COSM5444731	c.215C>A	p.A72D	Substitution - Missense	Oesophagus
COSM233095	c.595C>T	p.H199Y	Substitution - Missense	Skin
COSM3417255	c.2929G>T	p.E977*	Substitution - Nonsense	Large_intestine
COSM431973	c.65C>G	p.S22C	Substitution - Missense	Breast
COSM1628920	c.42G>A	p.G14G	Substitution - coding silent	Liver
COSM1364811	c.2576G>A	p.R859H	Substitution - Missense	Large_intestine
COSM78295	c.301G>A	p.A101T	Substitution - Missense	Ovary
COSM217046	c.1941_1953del13	p.E648fs*15	Deletion - Frameshift	Liver
COSM5754019	c.1221delC	p.Q408fs*95	Deletion - Frameshift	Large_intestine
COSM944334	c.357T>C	p.S119S	Substitution - coding silent	Endometrium
COSM4575778	c.217G>A	p.V73I	Substitution - Missense	Bone
COSM119950	c.959C>T	p.T320I	Substitution - Missense	Ovary
COSM1364810	c.2518delA	p.M842fs*1	Deletion - Frameshift	Large_intestine
COSM6000675	c.2023G>T	p.E675*	Substitution - Nonsense	Prostate
COSM5810971	c.439G>T	p.A147S	Substitution - Missense	Liver
COSM357495	c.2648G>A	p.R883Q	Substitution - Missense	Lung
COSM304414	c.863A>G	p.H288R	Substitution - Missense	Large_intestine
COSM121537	c.2475G>A	p.K825K	Substitution - coding silent	Upper_aerodigestive_tract
COSM5051984	c.545C>T	p.A182V	Substitution - Missense	Stomach
COSM1162342	c.918A>G	p.R306R	Substitution - coding silent	Thyroid
COSM4986956	c.1735C>G	p.P579A	Substitution - Missense	Soft_tissue
COSM4045327	c.623T>C	p.L208S	Substitution - Missense	Stomach
COSM4147509	c.415T>C	p.S139P	Substitution - Missense	Thyroid
COSM5030622	c.1540_1551del12	p.K514_A517delKMSA	Deletion - In frame	Bone
COSM1162342	c.918A>G	p.R306R	Substitution - coding silent	Thyroid
COSM5051985	c.2775A>C	p.L925F	Substitution - Missense	Stomach
COSM3671211	c.2194C>A	p.Q732K	Substitution - Missense	Prostate
COSM4045331	c.2895G>T	p.Q965H	Substitution - Missense	Stomach
COSM4801901	c.2567G>T	p.R856L	Substitution - Missense	Liver
COSM1162342	c.918A>G	p.R306R	Substitution - coding silent	Thyroid
COSM5424934	c.933G>A	p.V311V	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM4148989	c.2554C>T	p.R852C	Substitution - Missense	Ovary
COSM3466325	c.499C>T	p.R167W	Substitution - Missense	Skin
COSM2044754	c.347G>A	p.R116Q	Substitution - Missense	Breast
COSM1162342	c.918A>G	p.R306R	Substitution - coding silent	Oesophagus
COSM2044763	c.1066A>T	p.T356S	Substitution - Missense	Large_intestine
COSM1162342	c.918A>G	p.R306R	Substitution - coding silent	Pancreas
COSM1364805	c.1064G>A	p.R355Q	Substitution - Missense	Large_intestine
COSM1747289	c.2660A>C	p.N887T	Substitution - Missense	Urinary_tract
COSM944336	c.1287G>A	p.Q429Q	Substitution - coding silent	Large_intestine
COSM4713890	c.1230G>A	p.R410R	Substitution - coding silent	Large_intestine
COSM3931754	c.1749G>A	p.Q583Q	Substitution - coding silent	Urinary_tract
COSM4147510	c.746C>T	p.A249V	Substitution - Missense	Thyroid
COSM1628920	c.42G>A	p.G14G	Substitution - coding silent	Liver
COSM3688478	c.2256G>T	p.V752V	Substitution - coding silent	Large_intestine
COSM3466323	c.426C>A	p.L142L	Substitution - coding silent	Skin
COSM944336	c.1287G>A	p.Q429Q	Substitution - coding silent	Endometrium
COSM6014836	c.392C>T	p.S131F	Substitution - Missense	Skin
COSM376599	c.246G>A	p.R82R	Substitution - coding silent	Lung
COSM3738588	c.2321C>G	p.T774S	Substitution - Missense	Liver
COSM4045330	c.2416T>A	p.Y806N	Substitution - Missense	Stomach
COSM1239816	c.282G>A	p.Q94Q	Substitution - coding silent	Oesophagus
COSM1364809	c.2469C>T	p.C823C	Substitution - coding silent	Large_intestine
COSM5461549	c.1271C>T	p.A424V	Substitution - Missense	Liver
COSM944335	c.748G>T	p.V250L	Substitution - Missense	Endometrium
COSM944335	c.748G>T	p.V250L	Substitution - Missense	Endometrium
COSM2044763	c.1066A>T	p.T356S	Substitution - Missense	Large_intestine
COSM2044782	c.2185G>A	p.V729M	Substitution - Missense	Central_nervous_system
COSM4749711	c.1912G>T	p.A638S	Substitution - Missense	Stomach
COSM4801901	c.2567G>T	p.R856L	Substitution - Missense	Liver
COSM217046	c.1941_1953del13	p.E648fs*15	Deletion - Frameshift	Liver
COSM5980254	c.2517_2518insA	p.M842fs*23	Insertion - Frameshift	Upper_aerodigestive_tract
COSM5633825	c.1089G>T	p.Q363H	Substitution - Missense	Oesophagus
COSM3998981	c.2077A>C	p.T693P	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM944339	c.2253+1G>A	p.?	Unknown	Endometrium
COSM1364809	c.2469C>T	p.C823C	Substitution - coding silent	Cervix
COSM233095	c.595C>T	p.H199Y	Substitution - Missense	Skin
COSM294697	c.2561G>A	p.R854H	Substitution - Missense	Large_intestine
COSM4500164	c.558C>T	p.V186V	Substitution - coding silent	Skin
COSM3955287	c.2507G>A	p.R836Q	Substitution - Missense	Lung
COSM3466327	c.1221C>T	p.F407F	Substitution - coding silent	Skin
COSM4801637	c.2505C>A	p.F835L	Substitution - Missense	Liver
COSM4389206	c.2015T>C	p.V672A	Substitution - Missense	Pancreas
COSM1606741	c.1165C>T	p.Q389*	Substitution - Nonsense	Haematopoietic_and_lymphoid_tissue
COSM4655215	c.316G>A	p.A106T	Substitution - Missense	Large_intestine
COSM217046	c.1941_1953del13	p.E648fs*15	Deletion - Frameshift	Liver
COSM4801637	c.2505C>A	p.F835L	Substitution - Missense	Liver
COSM1364814	c.2648delG	p.G884fs*21	Deletion - Frameshift	Large_intestine
COSM4944233	c.456+8A>G	p.?	Unknown	Liver
COSM3466322	c.118C>T	p.L40L	Substitution - coding silent	Skin
COSM5623107	c.1794G>C	p.V598V	Substitution - coding silent	Oesophagus
COSM1364804	c.427A>G	p.N143D	Substitution - Missense	Large_intestine
COSM944336	c.1287G>A	p.Q429Q	Substitution - coding silent	Large_intestine
COSM3466329	c.1978C>T	p.P660S	Substitution - Missense	Skin
COSM1364807	c.2281T>C	p.S761P	Substitution - Missense	Large_intestine
COSM1364803	c.399A>T	p.L133L	Substitution - coding silent	Large_intestine
COSM328308	c.36C>A	p.T12T	Substitution - coding silent	Pancreas
COSM4548066	c.438G>A	p.Q146Q	Substitution - coding silent	Skin
COSM1364810	c.2518delA	p.M842fs*1	Deletion - Frameshift	Large_intestine
COSM5448555	c.2760A>G	p.P920P	Substitution - coding silent	Large_intestine
COSM1364813	c.2635G>T	p.E879*	Substitution - Nonsense	Large_intestine
COSM944341	c.2495G>A	p.S832N	Substitution - Missense	Endometrium
COSM4517780	c.418_419CC>TT	p.P140L	Substitution - Missense	Skin
COSM3700360	c.225+6A>T	p.?	Unknown	Liver
COSM5767281	c.1194G>A	p.Q398Q	Substitution - coding silent	Breast
COSM4593566	c.1537_1548del12	p.K514_A517delKMSA	Deletion - In frame	Upper_aerodigestive_tract
COSM1493074	c.2162A>G	p.D721G	Substitution - Missense	Kidney
COSM4713891	c.2221T>A	p.F741I	Substitution - Missense	Large_intestine
COSM294696	c.133C>T	p.R45W	Substitution - Missense	Large_intestine
COSM1606741	c.1165C>T	p.Q389*	Substitution - Nonsense	Haematopoietic_and_lymphoid_tissue
COSM2044778	c.1894-8C>T	p.?	Unknown	Prostate
COSM4636283	c.279G>A	p.Q93Q	Substitution - coding silent	Large_intestine
COSM5787636	c.2250C>A	p.F750L	Substitution - Missense	Breast
COSM5461549	c.1271C>T	p.A424V	Substitution - Missense	Large_intestine

> Text Mining based Variations [ TOP ]
There is no record for PHC1.

Summary
Symbol	PHC1
Name	polyhomeotic homolog 1
Aliases	HPH1; RAE28; EDR1; early development regulator 1 (homolog of polyhomeotic 1); polyhomeotic-like 1 (Drosophil ......
Location	12p13.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

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Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
P78364	898	S	Phosphoserine	-	No	None detected
P78364	922	T	Phosphothreonine	-	No	None detected

Summary
Symbol	PHC1
Name	polyhomeotic homolog 1
Aliases	HPH1; RAE28; EDR1; early development regulator 1 (homolog of polyhomeotic 1); polyhomeotic-like 1 (Drosophil ......
Location	12p13.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

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Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	4.729	4.407	-0.276	0.197	NS
BRCA	Breast invasive carcinoma	112	1100	4.789	4.587	-0.215	0.000293	NS
CESC	Cervical and endocervical cancers	3	306	5.163	3.846	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	3.218	3.535	0.128	0.25	NS
ESCA	Esophageal carcinoma	11	185	4.739	4.122	-0.83	0.0093	Under
GBM	Glioblastoma multiforme	5	166	5.021	5.788	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	3.898	3.251	-0.699	4.82e-08	Under
KIRC	Kidney renal clear cell carcinoma	72	534	4.852	5.161	0.306	2.84e-05	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	4.885	5.078	0.174	0.124	NS
LAML	Acute Myeloid Leukemia	0	173	NA	5.952	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	6.14	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	2.236	1.96	-0.352	0.0312	NS
LUAD	Lung adenocarcinoma	59	517	4.637	4.158	-0.403	4.55e-05	NS
LUSC	Lung squamous cell carcinoma	51	501	4.695	4.189	-0.491	3.19e-05	NS
OV	Ovarian serous cystadenocarcinoma	0	307	NA	5.369	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	5.082	4.495	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	4.18	5.282	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	4.786	4.612	-0.17	0.0251	NS
READ	Rectum adenocarcinoma	10	167	3.988	3.589	-0.119	0.676	NS
SARC	Sarcoma	2	263	4.658	5.025	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	4.527	4.964	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	4.894	4.059	-0.707	4.51e-06	Under
TGCT	Testicular Germ Cell Tumors	0	156	NA	8.755	NA	NA	NA
THCA	Thyroid carcinoma	59	509	5.271	4.949	-0.27	9.39e-06	NS
THYM	Thymoma	2	120	5.941	5.578	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	5.871	5.558	-0.345	0.0143	NS

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	14.6
Adrenal gland	19.9
Appendix	28.2
Bone marrow	5.2
Breast	13.9
Cerebral cortex	34.5
Cervix, uterine	26.1
Colon	8.4
Duodenum	8.2
Endometrium	57.5
Epididymis	17.3
Esophagus	21.5
Fallopian tube	43.8
Gallbladder	30
Heart muscle	11.2
Kidney	13.2
Liver	2.4
Lung	25.3
Lymph node	22.6
Ovary	42.2
Pancreas	3.1
Parathyroid gland	60.3
Placenta	22.8
Prostate	31.6
Rectum	11.9
Salivary gland	11
Seminal vesicle	32.5
Skeletal muscle	5
Skin	5.9
Small intestine	10.9
Smooth muscle	37.1
Spleen	23.1
Stomach	11.8
Testis	80.4
Thyroid gland	41.6
Tonsil	15.9
Urinary bladder	16.3

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
12660824	overexpression	Testicular Germ Cell Tumor	Genes such as CCND2, GLU3, LRP6 and HPH1 at 12p13 were also overexpressed.

Summary
Symbol	PHC1
Name	polyhomeotic homolog 1
Aliases	HPH1; RAE28; EDR1; early development regulator 1 (homolog of polyhomeotic 1); polyhomeotic-like 1 (Drosophil ......
Location	12p13.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.33	1.06e-11	13.9	55.2	30.9	Neutral
BRCA	Breast invasive carcinoma	1075	0.479	7.22e-63	14.8	62	23.2	Neutral
CESC	Cervical and endocervical cancers	292	0.328	9.73e-09	15.1	66.4	18.5	Neutral
COAD	Colon adenocarcinoma	449	0.155	0.00101	11.6	66.6	21.8	Neutral
ESCA	Esophageal carcinoma	183	0.323	8.37e-06	18.6	48.1	33.3	Neutral
GBM	Glioblastoma multiforme	147	0.401	4.73e-07	9.5	78.2	12.2	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.46	2.9e-28	8.6	60.1	31.3	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.026	0.554	1.3	75.6	23	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.315	4.79e-08	1	59.7	39.2	Gain
LAML	Acute Myeloid Leukemia	166	0.107	0.17	3	97	0	Neutral
LGG	Brain Lower Grade Glioma	513	0.473	5.02e-30	5.1	83.8	11.1	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.231	8.24e-06	22	65.9	12.1	Neutral
LUAD	Lung adenocarcinoma	512	0.339	2.89e-15	25.8	46.7	27.5	Neutral
LUSC	Lung squamous cell carcinoma	498	0.429	1.07e-23	7	43.6	49.4	Gain
OV	Ovarian serous cystadenocarcinoma	300	0.664	1.65e-39	15.3	34.3	50.3	Gain
PAAD	Pancreatic adenocarcinoma	177	0.602	8.04e-19	15.3	67.2	17.5	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.246	0.00163	1.9	91.4	6.8	Neutral
PRAD	Prostate adenocarcinoma	491	0.373	1.16e-17	17.3	79.8	2.9	Neutral
READ	Rectum adenocarcinoma	164	0.513	2.26e-12	15.9	61.6	22.6	Neutral
SARC	Sarcoma	255	0.463	5.62e-15	29	52.9	18	Neutral
SKCM	Skin Cutaneous Melanoma	367	0.436	1.95e-18	16.1	65.4	18.5	Neutral
STAD	Stomach adenocarcinoma	413	0.221	5.75e-06	17.9	59.6	22.5	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.069	0.402	0	2	98	Gain
THCA	Thyroid carcinoma	497	0.028	0.538	0.2	97.2	2.6	Neutral
THYM	Thymoma	119	0.011	0.903	5.9	90.8	3.4	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.305	5.1e-13	9.3	76.2	14.5	Neutral

Summary
Symbol	PHC1
Name	polyhomeotic homolog 1
Aliases	HPH1; RAE28; EDR1; early development regulator 1 (homolog of polyhomeotic 1); polyhomeotic-like 1 (Drosophil ......
Location	12p13.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.429	0	17	408	0.017	0.731	NS/NA
BRCA	Breast invasive carcinoma	-0.262	5.44e-15	83	785	-0.007	0.563	NS/NA
CESC	Cervical and endocervical cancers	-0.444	0	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.114	0.0433	19	297	0.005	0.0671	NS/NA
ESCA	Esophageal carcinoma	-0.163	0.0232	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.628	4.91e-08	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.291	6.59e-12	20	522	0.22	2.16e-12	Increased
KIRC	Kidney renal clear cell carcinoma	-0.215	6.45e-05	24	319	-0.005	0.393	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.154	0.00784	23	275	-0.001	0.603	NS/NA
LAML	Acute Myeloid Leukemia	0.009	0.911	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.451	0	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.152	0.00194	41	373	-0.005	0.255	NS/NA
LUAD	Lung adenocarcinoma	-0.306	1.17e-11	21	456	0.155	1.67e-17	NS/NA
LUSC	Lung squamous cell carcinoma	-0.171	0.000853	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.633	0.076	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.15	0.0431	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.424	2.19e-09	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.179	3.47e-05	35	498	-0.022	0.00656	NS/NA
READ	Rectum adenocarcinoma	-0.055	0.586	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.531	0	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.35	6.53e-15	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.231	6.94e-06	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.235	0.00327	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.182	1.47e-05	50	509	0	0.321	NS/NA
THYM	Thymoma	-0.171	0.0599	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.381	0	34	431	0	0.075	NS/NA

Summary
Symbol	PHC1
Name	polyhomeotic homolog 1
Aliases	HPH1; RAE28; EDR1; early development regulator 1 (homolog of polyhomeotic 1); polyhomeotic-like 1 (Drosophil ......
Location	12p13.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	2	Medium
Appendix	1	Low
Bone marrow	2	Medium
Breast	2	Medium
Bronchus	3	High
Caudate	2	Medium
Cerebellum	2	Medium
Cerebral cortex	3	High
Cervix, uterine	2	Medium
Colon	3	High
Duodenum	1	Low
Endometrium	2	Medium
Epididymis	2	Medium
Esophagus	1	Low
Fallopian tube	3	High
Gallbladder	3	High
Heart muscle	2	Medium
Hippocampus	2	Medium
Kidney	2	Medium
Liver	2	Medium
Lung	2	Medium
Lymph node	2	Medium
Nasopharynx	3	High
Oral mucosa	2	Medium
Ovary	2	Medium
Pancreas	3	High
Parathyroid gland	3	High
Placenta	3	High
Prostate	2	Medium
Rectum	3	High
Salivary gland	2	Medium
Seminal vesicle	2	Medium
Skeletal muscle	0	Not detected
Skin	3	High
Small intestine	0	Not detected
Smooth muscle	2	Medium
Soft tissue	3	High
Spleen	1	Low
Stomach	2	Medium
Testis	3	High
Thyroid gland	2	Medium
Tonsil	2	Medium
Urinary bladder	2	Medium
Vagina	1	Low

Summary
Symbol	PHC1
Name	polyhomeotic homolog 1
Aliases	HPH1; RAE28; EDR1; early development regulator 1 (homolog of polyhomeotic 1); polyhomeotic-like 1 (Drosophil ......
Location	12p13.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.197	NS	24476821
BRCA	Breast invasive carcinoma	521	0.000802	Significant	23000897
COAD	Colon adenocarcinoma	149	0.126	NS	22810696
GBM	Glioblastoma multiforme	157	6.22e-09	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	1.45e-13	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	4.42e-05	Significant	26536169
LGG	Brain Lower Grade Glioma	513	1.59e-20	Significant	26824661
LUAD	Lung adenocarcinoma	230	0.000382	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	4.82e-08	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	1.23e-11	Significant	21720365
PRAD	Prostate adenocarcinoma	333	0.0672	NS	26544944
READ	Rectum adenocarcinoma	67	0.00941	Significant	22810696
SKCM	Skin Cutaneous Melanoma	315	0.00682	Significant	26091043
STAD	Stomach adenocarcinoma	277	7.79e-09	Significant	25079317
THCA	Thyroid carcinoma	391	0.138	NS	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.0167	Significant	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	0.644	0.0356	Longer
BRCA	Breast invasive carcinoma	1079	0.73	0.158	NS
CESC	Cervical and endocervical cancers	291	0.97	0.934	NS
COAD	Colon adenocarcinoma	439	1.325	0.342	NS
ESCA	Esophageal carcinoma	184	0.84	0.604	NS
GBM	Glioblastoma multiforme	158	0.814	0.419	NS
HNSC	Head and Neck squamous cell carcinoma	518	0.825	0.306	NS
KIRC	Kidney renal clear cell carcinoma	531	1.175	0.416	NS
KIRP	Kidney renal papillary cell carcinoma	287	1.17	0.721	NS
LAML	Acute Myeloid Leukemia	149	0.933	0.816	NS
LGG	Brain Lower Grade Glioma	511	0.415	0.00054	Longer
LIHC	Liver hepatocellular carcinoma	365	1.025	0.924	NS
LUAD	Lung adenocarcinoma	502	0.742	0.173	NS
LUSC	Lung squamous cell carcinoma	494	1.475	0.044	Shorter
OV	Ovarian serous cystadenocarcinoma	303	1.405	0.119	NS
PAAD	Pancreatic adenocarcinoma	177	0.456	0.0153	Longer
PCPG	Pheochromocytoma and Paraganglioma	179	0.72	0.718	NS
PRAD	Prostate adenocarcinoma	497	0.722	0.709	NS
READ	Rectum adenocarcinoma	159	0.43	0.174	NS
SARC	Sarcoma	259	1.564	0.107	NS
SKCM	Skin Cutaneous Melanoma	459	1.406	0.0762	NS
STAD	Stomach adenocarcinoma	388	1.381	0.15	NS
TGCT	Testicular Germ Cell Tumors	134	0	0.317	NS
THCA	Thyroid carcinoma	500	1.248	0.787	NS
THYM	Thymoma	119	0.228	0.142	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	0.728	0.261	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	-0.078	0.115	NS
BRCA	Breast invasive carcinoma	1071	-0.062	0.0441	Lower
CESC	Cervical and endocervical cancers	167	0.103	0.184	NS
COAD	Colon adenocarcinoma	445	-0.038	0.426	NS
ESCA	Esophageal carcinoma	162	0.105	0.184	NS
HNSC	Head and Neck squamous cell carcinoma	448	0.084	0.0747	NS
KIRC	Kidney renal clear cell carcinoma	531	-0.093	0.0316	Lower
KIRP	Kidney renal papillary cell carcinoma	260	-0.097	0.118	NS
LIHC	Liver hepatocellular carcinoma	347	0.003	0.955	NS
LUAD	Lung adenocarcinoma	507	-0.047	0.288	NS
LUSC	Lung squamous cell carcinoma	497	0.011	0.803	NS
OV	Ovarian serous cystadenocarcinoma	302	-0.167	0.00366	Lower
PAAD	Pancreatic adenocarcinoma	176	-0.137	0.0702	NS
READ	Rectum adenocarcinoma	156	0.01	0.901	NS
SKCM	Skin Cutaneous Melanoma	410	-0.048	0.328	NS
STAD	Stomach adenocarcinoma	392	0.09	0.0738	NS
TGCT	Testicular Germ Cell Tumors	81	-0.146	0.194	NS
THCA	Thyroid carcinoma	499	-0.103	0.0215	Lower
UCEC	Uterine Corpus Endometrial Carcinoma	501	-0.081	0.0697	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	-0.029	0.637	NS
HNSC	Head and Neck squamous cell carcinoma	498	0.272	6.5e-10	Higher
KIRC	Kidney renal clear cell carcinoma	525	-0.187	1.54e-05	Lower
LGG	Brain Lower Grade Glioma	514	-0.102	0.0204	Lower
LIHC	Liver hepatocellular carcinoma	366	0.141	0.00706	Higher
OV	Ovarian serous cystadenocarcinoma	296	-0.011	0.846	NS
PAAD	Pancreatic adenocarcinoma	176	-0.088	0.248	NS
STAD	Stomach adenocarcinoma	406	0.148	0.00286	Higher
UCEC	Uterine Corpus Endometrial Carcinoma	534	-0.259	1.17e-09	Lower

Summary
Symbol	PHC1
Name	polyhomeotic homolog 1
Aliases	HPH1; RAE28; EDR1; early development regulator 1 (homolog of polyhomeotic 1); polyhomeotic-like 1 (Drosophil ......
Location	12p13.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	PHC1
Name	polyhomeotic homolog 1
Aliases	HPH1; RAE28; EDR1; early development regulator 1 (homolog of polyhomeotic 1); polyhomeotic-like 1 (Drosophil ......
Location	12p13.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for PHC1.

Summary
Symbol	PHC1
Name	polyhomeotic homolog 1
Aliases	HPH1; RAE28; EDR1; early development regulator 1 (homolog of polyhomeotic 1); polyhomeotic-like 1 (Drosophil ......
Location	12p13.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining [ TOP ]
There is no record for PHC1.