CR2Cancer

Summary
Symbol	PHC2
Name	polyhomeotic homolog 2
Aliases	EDR2; early development regulator 2 (homolog of polyhomeotic 2); polyhomeotic-like 2 (Drosophila); early dev ......
Location	1p35.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

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Domain

PF00536 SAM domain (Sterile alpha motif)

Function

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.

Classification

Class	Modification	Substrate	Product	PubMed
Polycomb group (PcG) protein	#	#	#	16024804

> Gene Ontology [ TOP ]
Biological Process	GO:0007283 spermatogenesis GO:0016925 protein sumoylation GO:0018205 peptidyl-lysine modification GO:0048232 male gamete generation
Molecular Function	-
Cellular Component	GO:0000151 ubiquitin ligase complex GO:0000152 nuclear ubiquitin ligase complex GO:0000785 chromatin GO:0000792 heterochromatin GO:0031519 PcG protein complex GO:0035102 PRC1 complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-2559583: Cellular Senescence R-HSA-2262752: Cellular responses to stress R-HSA-392499: Metabolism of proteins R-HSA-2559580: Oxidative Stress Induced Senescence R-HSA-597592: Post-translational protein modification R-HSA-3108232: SUMO E3 ligases SUMOylate target proteins R-HSA-2990846: SUMOylation R-HSA-3108214: SUMOylation of DNA damage response and repair proteins R-HSA-4570464: SUMOylation of RNA binding proteins

> KEGG and Reactome Pathway

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KEGG

Reactome

R-HSA-2559583: Cellular Senescence
R-HSA-2262752: Cellular responses to stress
R-HSA-392499: Metabolism of proteins
R-HSA-2559580: Oxidative Stress Induced Senescence
R-HSA-597592: Post-translational protein modification
R-HSA-3108232: SUMO E3 ligases SUMOylate target proteins
R-HSA-2990846: SUMOylation
R-HSA-3108214: SUMOylation of DNA damage response and repair proteins
R-HSA-4570464: SUMOylation of RNA binding proteins

Summary
Symbol	PHC2
Name	polyhomeotic homolog 2
Aliases	EDR2; early development regulator 2 (homolog of polyhomeotic 2); polyhomeotic-like 2 (Drosophila); early dev ......
Location	1p35.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

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COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM5799801	c.1720G>A	p.E574K	Substitution - Missense	Breast
COSM5483833	c.1311C>T	p.P437P	Substitution - coding silent	Large_intestine
COSM4473503	c.1854C>T	p.T618T	Substitution - coding silent	Skin
COSM386042	c.2028G>C	p.R676R	Substitution - coding silent	Lung
COSM426121	c.610G>C	p.V204L	Substitution - Missense	Breast
COSM1341905	c.2130G>T	p.K710N	Substitution - Missense	Large_intestine
COSM908422	c.2449C>T	p.R817C	Substitution - Missense	Skin
COSM2154955	c.2497C>A	p.H833N	Substitution - Missense	Central_nervous_system
COSM269877	c.917G>A	p.G306D	Substitution - Missense	Large_intestine
COSM5025239	c.1451_1455delAGACG	p.E484fs*26	Deletion - Frameshift	Breast
COSM3488296	c.168C>T	p.T56T	Substitution - coding silent	Skin
COSM1220320	c.1985C>T	p.S662F	Substitution - Missense	Large_intestine
COSM908430	c.235T>C	p.Y79H	Substitution - Missense	Endometrium
COSM1602235	c.1759-7C>G	p.?	Unknown	Liver
COSM2078739	c.1967G>A	p.R656H	Substitution - Missense	Liver
COSM1602235	c.1759-7C>G	p.?	Unknown	Liver
COSM4031593	c.1722A>C	p.E574D	Substitution - Missense	Stomach
COSM4237089	c.118C>T	p.P40S	Substitution - Missense	Skin
COSM3804991	c.1928A>C	p.E643A	Substitution - Missense	Breast
COSM5425062	c.1328C>T	p.T443I	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM908424	c.2078C>T	p.A693V	Substitution - Missense	Large_intestine
COSM1341912	c.115C>T	p.R39C	Substitution - Missense	Cervix
COSM1262028	c.2407A>G	p.I803V	Substitution - Missense	Oesophagus
COSM5380689	c.1664G>A	p.G555D	Substitution - Missense	Skin
COSM5511486	c.337A>C	p.S113R	Substitution - Missense	Biliary_tract
COSM4843982	c.231G>C	p.Q77H	Substitution - Missense	Cervix
COSM4713894	c.2034A>G	p.G678G	Substitution - coding silent	Large_intestine
COSM1341907	c.1814_1815insGGGTT	p.F605fs*128	Insertion - Frameshift	Large_intestine
COSM908428	c.1041A>T	p.Q347H	Substitution - Missense	Endometrium
COSM5952780	c.175-2A>C	p.?	Unknown	Oesophagus
COSM2154876	c.2495A>T	p.D832V	Substitution - Missense	Central_nervous_system
COSM3705797	c.347C>A	p.S116Y	Substitution - Missense	Liver
COSM2078774	c.271G>A	p.A91T	Substitution - Missense	Large_intestine
COSM4031598	c.162G>A	p.R54R	Substitution - coding silent	Stomach
COSM1627025	c.193C>T	p.H65Y	Substitution - Missense	Liver
COSM3746940	c.760C>T	p.P254S	Substitution - Missense	Large_intestine
COSM3751150	c.1524G>A	p.T508T	Substitution - coding silent	Large_intestine
COSM5735371	c.2577G>T	p.*859Y	Nonstop extension	Small_intestine
COSM1341908	c.1398G>T	p.Q466H	Substitution - Missense	Large_intestine
COSM908422	c.2449C>T	p.R817C	Substitution - Missense	Endometrium
COSM2078739	c.1967G>A	p.R656H	Substitution - Missense	Liver
COSM681068	c.387G>T	p.A129A	Substitution - coding silent	Lung
COSM4402472	c.1910C>T	p.P637L	Substitution - Missense	Skin
COSM2154875	c.2496C>G	p.D832E	Substitution - Missense	Central_nervous_system
COSM1724208	c.2040C>T	p.F680F	Substitution - coding silent	Skin
COSM1262029	c.818A>G	p.Q273R	Substitution - Missense	Stomach
COSM5729594	c.319G>A	p.A107T	Substitution - Missense	Skin
COSM4031595	c.1542G>A	p.P514P	Substitution - coding silent	Stomach
COSM390705	c.2538G>A	p.L846L	Substitution - coding silent	Lung
COSM3488295	c.892A>C	p.S298R	Substitution - Missense	Skin
COSM908427	c.1357G>A	p.A453T	Substitution - Missense	Endometrium
COSM4842661	c.682C>T	p.R228*	Substitution - Nonsense	Cervix
COSM2078744	c.1765C>T	p.R589C	Substitution - Missense	Large_intestine
COSM4787586	c.1930C>A	p.L644I	Substitution - Missense	Liver
COSM2078765	c.573G>A	p.Q191Q	Substitution - coding silent	Large_intestine
COSM292660	c.2158G>A	p.V720M	Substitution - Missense	Large_intestine
COSM2078760	c.1152C>T	p.S384S	Substitution - coding silent	Large_intestine
COSM5744241	c.1982G>T	p.C661F	Substitution - Missense	Small_intestine
COSM5437073	c.2047G>C	p.D683H	Substitution - Missense	Oesophagus
COSM4878934	c.1645G>A	p.G549S	Substitution - Missense	Prostate
COSM4713892	c.2325T>C	p.H775H	Substitution - coding silent	Large_intestine
COSM1262030	c.1566G>C	p.Q522H	Substitution - Missense	Oesophagus
COSM4031597	c.516C>T	p.G172G	Substitution - coding silent	Stomach
COSM908431	c.210G>A	p.T70T	Substitution - coding silent	Lung
COSM3997485	c.1556-7C>T	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM908434	c.169G>A	p.V57M	Substitution - Missense	Large_intestine
COSM2078764	c.753C>T	p.A251A	Substitution - coding silent	Cervix
COSM3804995	c.276G>A	p.A92A	Substitution - coding silent	Breast
COSM3488291	c.1815C>T	p.F605F	Substitution - coding silent	Skin
COSM908423	c.2095C>T	p.R699W	Substitution - Missense	Breast
COSM4713900	c.1620C>T	p.N540N	Substitution - coding silent	Large_intestine
COSM1602234	c.2533G>A	p.A845T	Substitution - Missense	Liver
COSM4031596	c.562C>T	p.L188L	Substitution - coding silent	Stomach
COSM2078767	c.481G>A	p.A161T	Substitution - Missense	Large_intestine
COSM2078770	c.386C>T	p.A129V	Substitution - Missense	Stomach
COSM1663466	c.1940G>A	p.R647Q	Substitution - Missense	Kidney
COSM3865354	c.1909C>T	p.P637S	Substitution - Missense	Skin
COSM1341912	c.115C>T	p.R39C	Substitution - Missense	Large_intestine
COSM5502215	c.159C>T	p.D53D	Substitution - coding silent	Biliary_tract
COSM4713898	c.1709C>T	p.T570M	Substitution - Missense	Large_intestine
COSM2078767	c.481G>A	p.A161T	Substitution - Missense	Large_intestine
COSM5380686	c.2375C>T	p.T792I	Substitution - Missense	Skin
COSM3751149	c.2547C>T	p.Y849Y	Substitution - coding silent	Large_intestine
COSM908433	c.201G>A	p.Q67Q	Substitution - coding silent	Endometrium
COSM1667362	c.1683G>T	p.Q561H	Substitution - Missense	Large_intestine
COSM3751151	c.1423G>A	p.V475M	Substitution - Missense	Large_intestine
COSM1321143	c.2466C>G	p.D822E	Substitution - Missense	Ovary
COSM4630013	c.375C>T	p.S125S	Substitution - coding silent	Large_intestine
COSM908424	c.2078C>T	p.A693V	Substitution - Missense	Endometrium
COSM1341909	c.771C>T	p.G257G	Substitution - coding silent	Large_intestine
COSM3966537	c.270C>T	p.T90T	Substitution - coding silent	Central_nervous_system
COSM1644888	c.1474C>T	p.H492Y	Substitution - Missense	Salivary_gland
COSM146212	c.2282G>C	p.R761P	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM145775	c.355C>A	p.Q119K	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5353473	c.919C>T	p.R307W	Substitution - Missense	Large_intestine
COSM4930792	c.495T>A	p.A165A	Substitution - coding silent	Liver
COSM1341906	c.1966C>T	p.R656C	Substitution - Missense	Large_intestine
COSM3943882	c.2299C>T	p.R767W	Substitution - Missense	Ovary
COSM72166	c.2250G>C	p.L750F	Substitution - Missense	Ovary
COSM2078744	c.1765C>T	p.R589C	Substitution - Missense	Large_intestine
COSM5506738	c.1858G>A	p.D620N	Substitution - Missense	Biliary_tract
COSM1724208	c.2040C>T	p.F680F	Substitution - coding silent	Skin
COSM251076	c.2393A>G	p.D798G	Substitution - Missense	Liver
COSM1341910	c.396G>A	p.P132P	Substitution - coding silent	Large_intestine
COSM4473010	c.1820C>T	p.P607L	Substitution - Missense	Skin
COSM1602234	c.2533G>A	p.A845T	Substitution - Missense	Liver
COSM5969368	c.213C>T	p.A71A	Substitution - coding silent	Upper_aerodigestive_tract
COSM908423	c.2095C>T	p.R699W	Substitution - Missense	Endometrium
COSM2154877	c.2494G>T	p.D832Y	Substitution - Missense	Central_nervous_system
COSM4396651	c.1931T>G	p.L644R	Substitution - Missense	Skin
COSM5417017	c.1758+2T>C	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM3741229	c.938C>T	p.T313M	Substitution - Missense	Liver
COSM1724208	c.2040C>T	p.F680F	Substitution - coding silent	Skin
COSM4527034	c.1437G>A	p.E479E	Substitution - coding silent	Skin
COSM908429	c.664-1G>A	p.?	Unknown	Endometrium
COSM1627025	c.193C>T	p.H65Y	Substitution - Missense	Liver
COSM908426	c.1719C>T	p.I573I	Substitution - coding silent	Endometrium
COSM5053414	c.2438C>T	p.A813V	Substitution - Missense	Stomach
COSM464464	c.1217C>A	p.P406Q	Substitution - Missense	Kidney
COSM4713903	c.831A>G	p.A277A	Substitution - coding silent	Large_intestine
COSM3804993	c.1927G>A	p.E643K	Substitution - Missense	Breast
COSM2078760	c.1152C>T	p.S384S	Substitution - coding silent	Large_intestine
COSM5001041	c.1420G>T	p.E474*	Substitution - Nonsense	Pancreas
COSM2078740	c.1908delT	p.L638fs*93	Deletion - Frameshift	Large_intestine
COSM1341911	c.241G>A	p.A81T	Substitution - Missense	Large_intestine
COSM236538	c.130C>A	p.Q44K	Substitution - Missense	Autonomic_ganglia
COSM3705797	c.347C>A	p.S116Y	Substitution - Missense	Liver
COSM5735372	c.2216G>A	p.R739H	Substitution - Missense	Small_intestine
COSM4472041	c.1756C>T	p.P586S	Substitution - Missense	Skin
COSM363032	c.942T>A	p.V314V	Substitution - coding silent	Lung
COSM4167417	c.2260T>G	p.S754A	Substitution - Missense	Central_nervous_system
COSM681069	c.1344C>G	p.F448L	Substitution - Missense	Lung
COSM3943884	c.615G>A	p.Q205Q	Substitution - coding silent	Ovary
COSM908421	c.2463C>A	p.I821I	Substitution - coding silent	Endometrium
COSM1341913	c.63C>T	p.S21S	Substitution - coding silent	Large_intestine
COSM3488293	c.1704C>T	p.I568I	Substitution - coding silent	Skin
COSM1667362	c.1683G>T	p.Q561H	Substitution - Missense	Large_intestine
COSM314117	c.2246C>G	p.P749R	Substitution - Missense	Lung
COSM185955	c.2168C>T	p.S723L	Substitution - Missense	Pancreas
COSM1748363	c.6G>C	p.E2D	Substitution - Missense	Urinary_tract
COSM4143830	c.828T>C	p.P276P	Substitution - coding silent	Thyroid
COSM3386096	c.174+5G>T	p.?	Unknown	Pancreas
COSM145775	c.355C>A	p.Q119K	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM2078766	c.522G>A	p.T174T	Substitution - coding silent	Oesophagus
COSM908432	c.209C>T	p.T70M	Substitution - Missense	Endometrium
COSM908431	c.210G>A	p.T70T	Substitution - coding silent	Endometrium
COSM146212	c.2282G>C	p.R761P	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1665970	c.1758+2T>A	p.?	Unknown	Kidney
COSM1473880	c.2011G>T	p.V671L	Substitution - Missense	Breast
COSM1239817	c.2079G>A	p.A693A	Substitution - coding silent	Oesophagus
COSM5726331	c.1127C>T	p.P376L	Substitution - Missense	Skin
COSM4806128	c.1798A>T	p.K600*	Substitution - Nonsense	Liver
COSM5691105	c.1345C>T	p.Q449*	Substitution - Nonsense	Soft_tissue
COSM1473881	c.1862C>T	p.S621L	Substitution - Missense	Breast
COSM2078743	c.1880A>G	p.Y627C	Substitution - Missense	Kidney
COSM4713902	c.1092G>A	p.Q364Q	Substitution - coding silent	Large_intestine
COSM5177044	c.828delT	p.A277fs*7	Deletion - Frameshift	Large_intestine
COSM3746940	c.760C>T	p.P254S	Substitution - Missense	Liver
COSM4941769	c.959A>G	p.H320R	Substitution - Missense	Liver
COSM4806128	c.1798A>T	p.K600*	Substitution - Nonsense	Liver
COSM125328	c.1299G>C	p.Q433H	Substitution - Missense	Upper_aerodigestive_tract
COSM1748363	c.6G>C	p.E2D	Substitution - Missense	Urinary_tract
COSM908420	c.2501T>C	p.L834P	Substitution - Missense	Endometrium
COSM4514077	c.961C>T	p.P321S	Substitution - Missense	Skin
COSM908434	c.169G>A	p.V57M	Substitution - Missense	Endometrium
COSM5988978	c.212C>A	p.A71D	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM2078744	c.1765C>T	p.R589C	Substitution - Missense	Large_intestine
COSM4617457	c.325G>A	p.V109I	Substitution - Missense	Large_intestine
COSM4713904	c.237C>T	p.Y79Y	Substitution - coding silent	Large_intestine
COSM4787586	c.1930C>A	p.L644I	Substitution - Missense	Liver
COSM1220321	c.1082C>A	p.P361Q	Substitution - Missense	Large_intestine
COSM1341909	c.771C>T	p.G257G	Substitution - coding silent	Large_intestine
COSM4925706	c.1587C>T	p.T529T	Substitution - coding silent	Liver
COSM5964263	c.770G>T	p.G257V	Substitution - Missense	Breast
COSM4647708	c.236A>G	p.Y79C	Substitution - Missense	Large_intestine
COSM3419136	c.584T>C	p.F195S	Substitution - Missense	Large_intestine
COSM246560	c.2298G>T	p.Q766H	Substitution - Missense	Prostate
COSM3751149	c.2547C>T	p.Y849Y	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM5725636	c.1741G>A	p.G581R	Substitution - Missense	Skin
COSM4577241	c.37A>G	p.S13G	Substitution - Missense	Bone
COSM5353473	c.919C>T	p.R307W	Substitution - Missense	Large_intestine
COSM908426	c.1719C>T	p.I573I	Substitution - coding silent	Large_intestine
COSM4752497	c.2153G>T	p.G718V	Substitution - Missense	Stomach
COSM251076	c.2393A>G	p.D798G	Substitution - Missense	Liver
COSM681071	c.2467G>C	p.G823R	Substitution - Missense	Lung
COSM4031599	c.116G>A	p.R39H	Substitution - Missense	Stomach
COSM464463	c.1994G>A	p.C665Y	Substitution - Missense	Kidney
COSM3930754	c.1936G>T	p.G646C	Substitution - Missense	Urinary_tract
COSM3746940	c.760C>T	p.P254S	Substitution - Missense	Pancreas
COSM4843781	c.1610C>A	p.T537N	Substitution - Missense	Cervix
COSM5380693	c.529C>T	p.P177S	Substitution - Missense	Skin
COSM1687351	c.2534C>T	p.A845V	Substitution - Missense	Skin
COSM4713896	c.1912delC	p.L638fs*93	Deletion - Frameshift	Large_intestine
COSM5053415	c.839A>G	p.K280R	Substitution - Missense	Stomach

> Text Mining based Variations [ TOP ]
There is no record for PHC2.

Summary
Symbol	PHC2
Name	polyhomeotic homolog 2
Aliases	EDR2; early development regulator 2 (homolog of polyhomeotic 2); polyhomeotic-like 2 (Drosophila); early dev ......
Location	1p35.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

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Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
Q8IXK0	621	S	Phosphoserine	-	Yes	p.S621L (cancer: BRCA)
Q8IXK0	751	S	Phosphoserine	-	No	None detected

Summary
Symbol	PHC2
Name	polyhomeotic homolog 2
Aliases	EDR2; early development regulator 2 (homolog of polyhomeotic 2); polyhomeotic-like 2 (Drosophila); early dev ......
Location	1p35.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

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Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	7.296	7.032	-0.125	0.438	NS
BRCA	Breast invasive carcinoma	112	1100	6.827	6.888	0.085	0.0619	NS
CESC	Cervical and endocervical cancers	3	306	7.623	6.777	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	6.508	7.066	0.465	2.41e-11	NS
ESCA	Esophageal carcinoma	11	185	7.344	6.788	-0.465	0.0167	NS
GBM	Glioblastoma multiforme	5	166	6.874	8.174	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	6.42	6.59	0.203	0.0306	NS
KIRC	Kidney renal clear cell carcinoma	72	534	7.306	7.655	0.323	1.6e-07	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	7.406	7.449	0.026	0.842	NS
LAML	Acute Myeloid Leukemia	0	173	NA	6.502	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	7.619	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	6.812	6.525	-0.359	8.06e-05	NS
LUAD	Lung adenocarcinoma	59	517	6.999	7.36	0.228	0.00139	NS
LUSC	Lung squamous cell carcinoma	51	501	7.143	6.682	-0.565	2.44e-09	NS
OV	Ovarian serous cystadenocarcinoma	0	307	NA	7.245	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	7.808	7.648	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	7.799	6.49	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	6.72	6.74	-0.026	0.621	NS
READ	Rectum adenocarcinoma	10	167	6.666	7.032	0.388	0.0165	NS
SARC	Sarcoma	2	263	7.793	7.517	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	7.432	7.947	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	7.209	7.122	-0.028	0.764	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	5.524	NA	NA	NA
THCA	Thyroid carcinoma	59	509	6.92	7.262	0.336	4.22e-15	NS
THYM	Thymoma	2	120	6.712	7.145	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	7.271	7.108	-0.142	0.0803	NS

> Cancer Cell Line Encyclopedia (CCLE)

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Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	9.3
Autonomic ganglia	CHP212	9.7
Autonomic ganglia	IMR32	9.6
Autonomic ganglia	KELLY	9.7
Autonomic ganglia	KPNRTBM1	9.3
Autonomic ganglia	KPNSI9S	10.1
Autonomic ganglia	KPNYN	9.7
Autonomic ganglia	MHHNB11	9.6
Autonomic ganglia	NB1	10.1
Autonomic ganglia	NH6	9.9
Autonomic ganglia	SHSY5Y	9.8
Autonomic ganglia	SIMA	9.2
Autonomic ganglia	SKNAS	11
Autonomic ganglia	SKNBE2	9.3
Autonomic ganglia	SKNDZ	9.9
Autonomic ganglia	SKNFI	10.2
Autonomic ganglia	SKNSH	10.1
Biliary tract	HUCCT1	9.9
Biliary tract	HUH28	10
Biliary tract	SNU1079	9.8
Biliary tract	SNU1196	11.6
Biliary tract	SNU245	9.6
Biliary tract	SNU308	10
Biliary tract	SNU478	9.6
Bone	143B	10.2
Bone	A673	10.4
Bone	CADOES1	9.6
Bone	CAL78	10.6
Bone	G292CLONEA141B1	10.3
Bone	HOS	9.3
Bone	HS706T	9.5
Bone	HS737T	9.9
Bone	HS819T	9.7
Bone	HS821T	10
Bone	HS822T	9.9
Bone	HS863T	9.9
Bone	HS870T	10.1
Bone	HS888T	10.1
Bone	MG63	9.7
Bone	MHHES1	10.3
Bone	OUMS27	10.4
Bone	RDES	10.7
Bone	SJSA1	9.9
Bone	SKES1	10.9
Bone	SKNMC	10.5
Bone	SW1353	10.3
Bone	T173	9.6
Bone	TC71	9.8
Bone	U2OS	9.8
Breast	AU565	9.3
Breast	BT20	9.4
Breast	BT474	9.7
Breast	BT483	9.3
Breast	BT549	10.8
Breast	CAL120	9.7
Breast	CAL148	10.5
Breast	CAL51	9.4
Breast	CAL851	9.7
Breast	CAMA1	9.4
Breast	DU4475	9.9
Breast	EFM192A	8.8
Breast	EFM19	8.9
Breast	EVSAT	9.8
Breast	HCC1143	9.4
Breast	HCC1187	10.9
Breast	HCC1395	10.1
Breast	HCC1419	8.9
Breast	HCC1428	9.6
Breast	HCC1500	9.8
Breast	HCC1569	9.6
Breast	HCC1599	9.7
Breast	HCC1806	8.6
Breast	HCC1937	9.4
Breast	HCC1954	9.3
Breast	HCC202	10.1
Breast	HCC2157	10.1
Breast	HCC2218	9.4
Breast	HCC38	10.4
Breast	HCC70	10.2
Breast	HDQP1	9.6
Breast	HMC18	10.2
Breast	HS274T	9.6
Breast	HS281T	9.9
Breast	HS343T	9.7
Breast	HS578T	9.9
Breast	HS606T	9.7
Breast	HS739T	9.9
Breast	HS742T	9.9
Breast	JIMT1	9.7
Breast	KPL1	8.9
Breast	MCF7	8.5
Breast	MDAMB134VI	9.2
Breast	MDAMB157	9.9
Breast	MDAMB175VII	9
Breast	MDAMB231	10.9
Breast	MDAMB361	10.2
Breast	MDAMB415	9.6
Breast	MDAMB436	10.5
Breast	MDAMB453	9.5
Breast	MDAMB468	10.1
Breast	SKBR3	9.3
Breast	T47D	8.7
Breast	UACC812	8.7
Breast	UACC893	9.3
Breast	YMB1	8.5
Breast	ZR751	8.3
Breast	ZR7530	9.2
Central nervous system	1321N1	9.7
Central nervous system	42MGBA	10.3
Central nervous system	8MGBA	10.7
Central nervous system	A172	9.9
Central nervous system	AM38	10.4
Central nervous system	BECKER	10.1
Central nervous system	CAS1	10.4
Central nervous system	CCFSTTG1	10.1
Central nervous system	D283MED	11.1
Central nervous system	D341MED	10.6
Central nervous system	DAOY	10.2
Central nervous system	DBTRG05MG	10.1
Central nervous system	DKMG	10.1
Central nervous system	GAMG	10.5
Central nervous system	GB1	10.3
Central nervous system	GI1	10.3
Central nervous system	GMS10	10.5
Central nervous system	GOS3	9.8
Central nervous system	H4	10
Central nervous system	HS683	11.1
Central nervous system	KALS1	10.7
Central nervous system	KG1C	10.8
Central nervous system	KNS42	9.4
Central nervous system	KNS60	10.2
Central nervous system	KNS81	10
Central nervous system	KS1	9.7
Central nervous system	LN18	10.3
Central nervous system	LN229	10.4
Central nervous system	M059K	10.2
Central nervous system	MOGGCCM	10.7
Central nervous system	MOGGUVW	10.8
Central nervous system	NMCG1	10.5
Central nervous system	ONS76	10.2
Central nervous system	SF126	9.7
Central nervous system	SF295	10.2
Central nervous system	SNB19	10.1
Central nervous system	SNU1105	10.5
Central nervous system	SNU201	10.4
Central nervous system	SNU466	10
Central nervous system	SNU489	11.1
Central nervous system	SNU626	9.3
Central nervous system	SNU738	9.9
Central nervous system	SW1088	10.5
Central nervous system	SW1783	10.1
Central nervous system	T98G	10.5
Central nervous system	TM31	10.1
Central nervous system	U118MG	11
Central nervous system	U138MG	10.8
Central nervous system	U251MG	10.1
Central nervous system	U87MG	11.4
Central nervous system	YH13	11
Central nervous system	YKG1	11.6
Endometrium	AN3CA	10
Endometrium	COLO684	11.3
Endometrium	EFE184	10.1
Endometrium	EN	9.2
Endometrium	ESS1	10.2
Endometrium	HEC108	9.7
Endometrium	HEC151	11.1
Endometrium	HEC1A	10
Endometrium	HEC1B	10
Endometrium	HEC251	9.2
Endometrium	HEC265	10.1
Endometrium	HEC50B	10.4
Endometrium	HEC59	9.6
Endometrium	HEC6	9.2
Endometrium	ISHIKAWAHERAKLIO02ER	9.1
Endometrium	JHUEM1	9.1
Endometrium	JHUEM2	10
Endometrium	JHUEM3	10.4
Endometrium	KLE	10.4
Endometrium	MFE280	9.9
Endometrium	MFE296	9.6
Endometrium	MFE319	9.8
Endometrium	RL952	9.7
Endometrium	SNGM	11
Endometrium	SNU1077	9.5
Endometrium	SNU685	10.4
Endometrium	TEN	9.1
Haematopoietic and lymphoid	697	10.5
Haematopoietic and lymphoid	A3KAW	9
Haematopoietic and lymphoid	A4FUK	8.3
Haematopoietic and lymphoid	ALLSIL	10.2
Haematopoietic and lymphoid	AML193	9.3
Haematopoietic and lymphoid	AMO1	8.4
Haematopoietic and lymphoid	BCP1	9.2
Haematopoietic and lymphoid	BDCM	8.5
Haematopoietic and lymphoid	BL41	9.3
Haematopoietic and lymphoid	BL70	9.5
Haematopoietic and lymphoid	BV173	9.8
Haematopoietic and lymphoid	CA46	9.2
Haematopoietic and lymphoid	CI1	9.1
Haematopoietic and lymphoid	CMK115	9.5
Haematopoietic and lymphoid	CMK86	10.1
Haematopoietic and lymphoid	CMK	9.8
Haematopoietic and lymphoid	CMLT1	9.9
Haematopoietic and lymphoid	COLO775	8.8
Haematopoietic and lymphoid	DAUDI	9.7
Haematopoietic and lymphoid	DB	10.1
Haematopoietic and lymphoid	DEL	9.9
Haematopoietic and lymphoid	DND41	10.2
Haematopoietic and lymphoid	DOHH2	10.1
Haematopoietic and lymphoid	EB1	9.4
Haematopoietic and lymphoid	EB2	9.5
Haematopoietic and lymphoid	EHEB	7.9
Haematopoietic and lymphoid	EJM	8.5
Haematopoietic and lymphoid	EM2	9
Haematopoietic and lymphoid	EOL1	9.5
Haematopoietic and lymphoid	F36P	9.5
Haematopoietic and lymphoid	GA10	9.5
Haematopoietic and lymphoid	GDM1	9.8
Haematopoietic and lymphoid	GRANTA519	8.2
Haematopoietic and lymphoid	HDLM2	8.5
Haematopoietic and lymphoid	HDMYZ	10.3
Haematopoietic and lymphoid	HEL9217	9.5
Haematopoietic and lymphoid	HEL	9.6
Haematopoietic and lymphoid	HH	9
Haematopoietic and lymphoid	HL60	9.5
Haematopoietic and lymphoid	HPBALL	10
Haematopoietic and lymphoid	HS604T	9.8
Haematopoietic and lymphoid	HS611T	9
Haematopoietic and lymphoid	HS616T	10.1
Haematopoietic and lymphoid	HS751T	9.5
Haematopoietic and lymphoid	HT	8.8
Haematopoietic and lymphoid	HTK	11.1
Haematopoietic and lymphoid	HUNS1	8.8
Haematopoietic and lymphoid	HUT102	9.1
Haematopoietic and lymphoid	HUT78	9.6
Haematopoietic and lymphoid	JEKO1	10
Haematopoietic and lymphoid	JK1	9.2
Haematopoietic and lymphoid	JM1	10.1
Haematopoietic and lymphoid	JURKAT	9.9
Haematopoietic and lymphoid	JURLMK1	10.8
Haematopoietic and lymphoid	JVM2	8
Haematopoietic and lymphoid	JVM3	8.1
Haematopoietic and lymphoid	K562	9.8
Haematopoietic and lymphoid	KARPAS299	10
Haematopoietic and lymphoid	KARPAS422	9.8
Haematopoietic and lymphoid	KARPAS620	8
Haematopoietic and lymphoid	KASUMI1	9.1
Haematopoietic and lymphoid	KASUMI2	10.6
Haematopoietic and lymphoid	KASUMI6	9.9
Haematopoietic and lymphoid	KCL22	9.4
Haematopoietic and lymphoid	KE37	9.5
Haematopoietic and lymphoid	KE97	8.8
Haematopoietic and lymphoid	KG1	9.5
Haematopoietic and lymphoid	KHM1B	8.2
Haematopoietic and lymphoid	KIJK	10.4
Haematopoietic and lymphoid	KMH2	9.1
Haematopoietic and lymphoid	KMM1	8.8
Haematopoietic and lymphoid	KMS11	9.1
Haematopoietic and lymphoid	KMS12BM	8.8
Haematopoietic and lymphoid	KMS18	8.9
Haematopoietic and lymphoid	KMS20	9.3
Haematopoietic and lymphoid	KMS21BM	8
Haematopoietic and lymphoid	KMS26	8.6
Haematopoietic and lymphoid	KMS27	8.3
Haematopoietic and lymphoid	KMS28BM	8.8
Haematopoietic and lymphoid	KMS34	8.1
Haematopoietic and lymphoid	KO52	10
Haematopoietic and lymphoid	KOPN8	10.5
Haematopoietic and lymphoid	KU812	10.1
Haematopoietic and lymphoid	KYO1	9.7
Haematopoietic and lymphoid	L1236	9.3
Haematopoietic and lymphoid	L363	8.7
Haematopoietic and lymphoid	L428	7.8
Haematopoietic and lymphoid	L540	9.2
Haematopoietic and lymphoid	LAMA84	9.5
Haematopoietic and lymphoid	LOUCY	9.4
Haematopoietic and lymphoid	LP1	9
Haematopoietic and lymphoid	M07E	9.7
Haematopoietic and lymphoid	MC116	9.3
Haematopoietic and lymphoid	ME1	10.3
Haematopoietic and lymphoid	MEC1	8.2
Haematopoietic and lymphoid	MEC2	8.2
Haematopoietic and lymphoid	MEG01	9.8
Haematopoietic and lymphoid	MHHCALL2	9.5
Haematopoietic and lymphoid	MHHCALL3	10.6
Haematopoietic and lymphoid	MHHCALL4	10.2
Haematopoietic and lymphoid	MINO	9.4
Haematopoietic and lymphoid	MJ	9.3
Haematopoietic and lymphoid	MM1S	8.9
Haematopoietic and lymphoid	MOLM13	9.4
Haematopoietic and lymphoid	MOLM16	10.1
Haematopoietic and lymphoid	MOLM6	10
Haematopoietic and lymphoid	MOLP2	8.9
Haematopoietic and lymphoid	MOLP8	7.7
Haematopoietic and lymphoid	MOLT13	10.2
Haematopoietic and lymphoid	MOLT16	9.6
Haematopoietic and lymphoid	MOLT4	9.7
Haematopoietic and lymphoid	MONOMAC1	9.6
Haematopoietic and lymphoid	MONOMAC6	9.9
Haematopoietic and lymphoid	MOTN1	9.4
Haematopoietic and lymphoid	MUTZ5	10.4
Haematopoietic and lymphoid	MV411	9.6
Haematopoietic and lymphoid	NALM19	10.4
Haematopoietic and lymphoid	NALM1	10.2
Haematopoietic and lymphoid	NALM6	9.6
Haematopoietic and lymphoid	NAMALWA	9.5
Haematopoietic and lymphoid	NB4	9.1
Haematopoietic and lymphoid	NCIH929	8.1
Haematopoietic and lymphoid	NCO2	8.5
Haematopoietic and lymphoid	NOMO1	9.5
Haematopoietic and lymphoid	NUDHL1	9.9
Haematopoietic and lymphoid	NUDUL1	9.6
Haematopoietic and lymphoid	OCIAML2	9.4
Haematopoietic and lymphoid	OCIAML3	10.6
Haematopoietic and lymphoid	OCIAML5	9.6
Haematopoietic and lymphoid	OCILY10	10
Haematopoietic and lymphoid	OCILY19	10.5
Haematopoietic and lymphoid	OCILY3	8.9
Haematopoietic and lymphoid	OCIM1	9
Haematopoietic and lymphoid	OPM2	8.5
Haematopoietic and lymphoid	P12ICHIKAWA	10
Haematopoietic and lymphoid	P31FUJ	9.7
Haematopoietic and lymphoid	P3HR1	8.6
Haematopoietic and lymphoid	PCM6	9.4
Haematopoietic and lymphoid	PEER	9.5
Haematopoietic and lymphoid	PF382	9.7
Haematopoietic and lymphoid	PFEIFFER	8.1
Haematopoietic and lymphoid	PL21	9.4
Haematopoietic and lymphoid	RAJI	9.4
Haematopoietic and lymphoid	RCHACV	10.2
Haematopoietic and lymphoid	REC1	9.2
Haematopoietic and lymphoid	REH	10.2
Haematopoietic and lymphoid	RI1	10.5
Haematopoietic and lymphoid	RL	8.9
Haematopoietic and lymphoid	RPMI8226	9
Haematopoietic and lymphoid	RPMI8402	10
Haematopoietic and lymphoid	RS411	9.9
Haematopoietic and lymphoid	SEM	10.1
Haematopoietic and lymphoid	SET2	9.9
Haematopoietic and lymphoid	SIGM5	8.8
Haematopoietic and lymphoid	SKM1	9.5
Haematopoietic and lymphoid	SKMM2	9
Haematopoietic and lymphoid	SR786	9.3
Haematopoietic and lymphoid	ST486	9.6
Haematopoietic and lymphoid	SUDHL10	9.7
Haematopoietic and lymphoid	SUDHL1	9.4
Haematopoietic and lymphoid	SUDHL4	10
Haematopoietic and lymphoid	SUDHL5	9.2
Haematopoietic and lymphoid	SUDHL6	8.4
Haematopoietic and lymphoid	SUDHL8	9.6
Haematopoietic and lymphoid	SUPB15	10.1
Haematopoietic and lymphoid	SUPHD1	8.3
Haematopoietic and lymphoid	SUPM2	8.9
Haematopoietic and lymphoid	SUPT11	9.8
Haematopoietic and lymphoid	SUPT1	9.7
Haematopoietic and lymphoid	TALL1	9.9
Haematopoietic and lymphoid	TF1	9.7
Haematopoietic and lymphoid	THP1	9
Haematopoietic and lymphoid	TO175T	9.9
Haematopoietic and lymphoid	TOLEDO	10
Haematopoietic and lymphoid	U266B1	8.1
Haematopoietic and lymphoid	U937	9.8
Haematopoietic and lymphoid	UT7	9.5
Haematopoietic and lymphoid	WSUDLCL2	9.7
Kidney	769P	10.7
Kidney	786O	10.5
Kidney	A498	9.5
Kidney	A704	9.7
Kidney	ACHN	9.9
Kidney	BFTC909	9.4
Kidney	CAKI1	10.1
Kidney	CAKI2	10
Kidney	CAL54	10.7
Kidney	KMRC1	9.7
Kidney	KMRC20	9.8
Kidney	KMRC2	10.4
Kidney	KMRC3	10
Kidney	OSRC2	9.8
Kidney	RCC10RGB	9.7
Kidney	SNU1272	10.5
Kidney	SNU349	10.3
Kidney	TUHR10TKB	10.9
Kidney	TUHR14TKB	10.5
Kidney	TUHR4TKB	10.3
Kidney	VMRCRCW	10.6
Kidney	VMRCRCZ	9.8
Large intestine	C2BBE1	8.7
Large intestine	CCK81	9.7
Large intestine	CL11	10.4
Large intestine	CL14	9.2
Large intestine	CL34	10.4
Large intestine	CL40	10.5
Large intestine	COLO205	10.3
Large intestine	COLO320	9.6
Large intestine	COLO678	9.6
Large intestine	CW2	10.1
Large intestine	DLD1	10.2
Large intestine	GP2D	9.8
Large intestine	HCC56	10
Large intestine	HCT116	10.6
Large intestine	HCT15	9.5
Large intestine	HS675T	10.3
Large intestine	HS698T	9.7
Large intestine	HT115	10.1
Large intestine	HT29	10.6
Large intestine	HT55	9.5
Large intestine	KM12	10.7
Large intestine	LOVO	9.5
Large intestine	LS1034	10.4
Large intestine	LS123	9.6
Large intestine	LS180	10.4
Large intestine	LS411N	10.1
Large intestine	LS513	9.9
Large intestine	MDST8	10.4
Large intestine	NCIH508	9.4
Large intestine	NCIH716	10.3
Large intestine	NCIH747	9.3
Large intestine	OUMS23	10
Large intestine	RCM1	10.2
Large intestine	RKO	10.7
Large intestine	SKCO1	9.8
Large intestine	SNU1040	10
Large intestine	SNU1197	10.5
Large intestine	SNU175	9.9
Large intestine	SNU283	9.9
Large intestine	SNU407	9.9
Large intestine	SNU503	8.4
Large intestine	SNU61	9.5
Large intestine	SNU81	10.9
Large intestine	SNUC1	10.7
Large intestine	SNUC2A	9.4
Large intestine	SNUC4	9.8
Large intestine	SNUC5	10.2
Large intestine	SW1116	9.8
Large intestine	SW1417	10.1
Large intestine	SW1463	10.5
Large intestine	SW403	10
Large intestine	SW480	10.3
Large intestine	SW48	9.8
Large intestine	SW620	10.2
Large intestine	SW837	9.9
Large intestine	SW948	9.7
Large intestine	T84	10.1
Liver	ALEXANDERCELLS	9.6
Liver	C3A	10.2
Liver	HEP3B217	10.1
Liver	HEPG2	10.4
Liver	HLE	9.7
Liver	HLF	10.2
Liver	HUH1	9.4
Liver	HUH6	9.5
Liver	HUH7	9.4
Liver	JHH1	9.5
Liver	JHH2	10.3
Liver	JHH4	10.7
Liver	JHH5	9.7
Liver	JHH6	9.7
Liver	JHH7	10.1
Liver	LI7	10
Liver	PLCPRF5	9.6
Liver	SKHEP1	10.1
Liver	SNU182	10
Liver	SNU387	10.9
Liver	SNU398	8.9
Liver	SNU423	10
Liver	SNU449	9.9
Liver	SNU475	10
Liver	SNU761	10
Liver	SNU878	9.5
Liver	SNU886	10.9
Lung	A549	9.5
Lung	ABC1	8.7
Lung	BEN	10
Lung	CAL12T	9.9
Lung	CALU1	10.2
Lung	CALU3	9.8
Lung	CALU6	10.5
Lung	CHAGOK1	8.5
Lung	COLO668	11.7
Lung	COLO699	9.9
Lung	CORL105	9.8
Lung	CORL23	10.5
Lung	CORL24	10.6
Lung	CORL279	10.9
Lung	CORL311	10.1
Lung	CORL47	10.3
Lung	CORL51	10.5
Lung	CORL88	10.8
Lung	CORL95	10.6
Lung	CPCN	10.1
Lung	DMS114	9.9
Lung	DMS153	10.9
Lung	DMS273	10.5
Lung	DMS454	10.2
Lung	DMS53	10.2
Lung	DMS79	10.7
Lung	DV90	9.1
Lung	EBC1	10.8
Lung	EPLC272H	9.3
Lung	HARA	8.4
Lung	HCC1171	10.2
Lung	HCC1195	11.8
Lung	HCC15	10.3
Lung	HCC2279	10.2
Lung	HCC2935	9.2
Lung	HCC33	11
Lung	HCC366	9.8
Lung	HCC4006	9.7
Lung	HCC44	10.6
Lung	HCC78	9.7
Lung	HCC827	9.5
Lung	HCC95	7.8
Lung	HLC1	9.7
Lung	HLFA	10
Lung	HS229T	10.2
Lung	HS618T	10.2
Lung	IALM	11.2
Lung	KNS62	9.2
Lung	LC1F	8.4
Lung	LC1SQSF	8.2
Lung	LCLC103H	9.8
Lung	LCLC97TM1	10.5
Lung	LK2	9.4
Lung	LOUNH91	9.8
Lung	LU65	10.4
Lung	LU99	9.3
Lung	LUDLU1	8.5
Lung	LXF289	10.9
Lung	MORCPR	9.6
Lung	NCIH1048	10.3
Lung	NCIH1092	10.7
Lung	NCIH1105	10.1
Lung	NCIH1155	9.8
Lung	NCIH1184	10.3
Lung	NCIH1299	10.5
Lung	NCIH1339	10.3
Lung	NCIH1341	9.9
Lung	NCIH1355	9.7
Lung	NCIH1373	11.7
Lung	NCIH1385	10.4
Lung	NCIH1395	9
Lung	NCIH1435	10.4
Lung	NCIH1436	9.6
Lung	NCIH1437	9.5
Lung	NCIH146	9.8
Lung	NCIH1563	9.9
Lung	NCIH1568	9.1
Lung	NCIH1573	9.3
Lung	NCIH1581	9.5
Lung	NCIH1618	10.5
Lung	NCIH1623	9.2
Lung	NCIH1648	9.8
Lung	NCIH1650	9.4
Lung	NCIH1651	9.1
Lung	NCIH1666	10.4
Lung	NCIH1693	9.5
Lung	NCIH1694	10.8
Lung	NCIH1703	9.5
Lung	NCIH1734	9.8
Lung	NCIH1755	10.4
Lung	NCIH1781	9.3
Lung	NCIH1792	10.1
Lung	NCIH1793	9.3
Lung	NCIH1836	10.3
Lung	NCIH1838	10.3
Lung	NCIH1869	9.6
Lung	NCIH1876	9.7
Lung	NCIH1915	10.4
Lung	NCIH1930	9.7
Lung	NCIH1944	9.5
Lung	NCIH1963	10.4
Lung	NCIH196	9.7
Lung	NCIH1975	9.7
Lung	NCIH2009	9.7
Lung	NCIH2023	9.3
Lung	NCIH2029	10.2
Lung	NCIH2030	10.3
Lung	NCIH2066	10.8
Lung	NCIH2081	9.9
Lung	NCIH2085	9.7
Lung	NCIH2087	10.8
Lung	NCIH209	11.5
Lung	NCIH2106	10.8
Lung	NCIH2110	9.2
Lung	NCIH211	9.9
Lung	NCIH2122	10
Lung	NCIH2126	9.5
Lung	NCIH2141	10.8
Lung	NCIH2170	9.1
Lung	NCIH2171	10.8
Lung	NCIH2172	8.8
Lung	NCIH2196	10.5
Lung	NCIH2227	10.6
Lung	NCIH2228	10.1
Lung	NCIH226	10.2
Lung	NCIH2286	10.6
Lung	NCIH2291	10.4
Lung	NCIH2342	8.8
Lung	NCIH2347	10.2
Lung	NCIH23	9.6
Lung	NCIH2405	9.7
Lung	NCIH2444	10.2
Lung	NCIH292	9.8
Lung	NCIH322	9.8
Lung	NCIH3255	10.2
Lung	NCIH358	10.4
Lung	NCIH441	11.3
Lung	NCIH446	10.4
Lung	NCIH460	8.8
Lung	NCIH510	10.5
Lung	NCIH520	9.5
Lung	NCIH522	9.9
Lung	NCIH524	10.3
Lung	NCIH526	10.7
Lung	NCIH596	9.6
Lung	NCIH647	10.4
Lung	NCIH650	11.2
Lung	NCIH661	9.2
Lung	NCIH69	9.4
Lung	NCIH727	10.2
Lung	NCIH810	11.3
Lung	NCIH82	9.9
Lung	NCIH838	8.2
Lung	NCIH841	9.4
Lung	NCIH854	11.2
Lung	NCIH889	10.3
Lung	PC14	9.8
Lung	RERFLCAD1	10.8
Lung	RERFLCAD2	9.9
Lung	RERFLCAI	10.1
Lung	RERFLCKJ	9.4
Lung	RERFLCMS	10.3
Lung	RERFLCSQ1	10.2
Lung	SBC5	9.3
Lung	SCLC21H	10
Lung	SHP77	10.4
Lung	SKLU1	10.9
Lung	SKMES1	10.5
Lung	SQ1	10.7
Lung	SW1271	10.9
Lung	SW1573	10.4
Lung	SW900	10.7
Lung	VMRCLCD	10.6
Lung	VMRCLCP	8.5
Oesophagus	COLO680N	9.1
Oesophagus	ECGI10	8.7
Oesophagus	KYSE140	8.8
Oesophagus	KYSE150	10.3
Oesophagus	KYSE180	8.9
Oesophagus	KYSE270	9.7
Oesophagus	KYSE30	9.3
Oesophagus	KYSE410	9.7
Oesophagus	KYSE450	9.3
Oesophagus	KYSE510	9.4
Oesophagus	KYSE520	9.2
Oesophagus	KYSE70	8.6
Oesophagus	OE19	10.4
Oesophagus	OE33	9
Oesophagus	TE10	9.6
Oesophagus	TE11	9.2
Oesophagus	TE14	8.9
Oesophagus	TE15	8.7
Oesophagus	TE1	9.4
Oesophagus	TE4	9.3
Oesophagus	TE5	9.2
Oesophagus	TE6	8.1
Oesophagus	TE8	9.1
Oesophagus	TE9	9
Oesophagus	TT	8.5
Ovary	59M	10.5
Ovary	A2780	9.3
Ovary	CAOV3	9.5
Ovary	CAOV4	9.3
Ovary	COLO704	10.6
Ovary	COV318	9.9
Ovary	COV362	9.9
Ovary	COV434	8.8
Ovary	COV504	9.9
Ovary	COV644	9.4
Ovary	EFO21	10.9
Ovary	EFO27	9.9
Ovary	ES2	9.9
Ovary	FUOV1	9.4
Ovary	HEYA8	9.7
Ovary	HS571T	9.7
Ovary	IGROV1	9.5
Ovary	JHOC5	10.6
Ovary	JHOM1	9.8
Ovary	JHOM2B	10.2
Ovary	JHOS2	9.8
Ovary	JHOS4	9.4
Ovary	KURAMOCHI	10.8
Ovary	MCAS	10.1
Ovary	NIHOVCAR3	9.5
Ovary	OAW28	9.4
Ovary	OAW42	9.1
Ovary	OC314	10.2
Ovary	OC316	10.2
Ovary	ONCODG1	9.8
Ovary	OV56	10.7
Ovary	OV7	11.1
Ovary	OV90	10.4
Ovary	OVCAR4	9.6
Ovary	OVCAR8	9.1
Ovary	OVISE	9
Ovary	OVK18	9.9
Ovary	OVKATE	9.1
Ovary	OVMANA	9
Ovary	OVSAHO	9.5
Ovary	OVTOKO	10.2
Ovary	RMGI	10.5
Ovary	RMUGS	9.9
Ovary	SKOV3	9.8
Ovary	SNU119	9.2
Ovary	SNU840	9.8
Ovary	SNU8	9.9
Ovary	TOV112D	9.7
Ovary	TOV21G	10.6
Ovary	TYKNU	10.2
Pancreas	ASPC1	10.3
Pancreas	BXPC3	10.1
Pancreas	CAPAN1	10.1
Pancreas	CAPAN2	10.7
Pancreas	CFPAC1	10.7
Pancreas	DANG	9.8
Pancreas	HPAC	9.5
Pancreas	HPAFII	10.2
Pancreas	HS766T	10.5
Pancreas	HUPT3	10.1
Pancreas	HUPT4	10
Pancreas	KCIMOH1	10.1
Pancreas	KLM1	9.9
Pancreas	KP2	9.2
Pancreas	KP3	10.6
Pancreas	KP4	9.7
Pancreas	L33	9
Pancreas	MIAPACA2	9.6
Pancreas	PANC0203	10.1
Pancreas	PANC0213	9.5
Pancreas	PANC0327	9.6
Pancreas	PANC0403	9.8
Pancreas	PANC0504	10
Pancreas	PANC0813	11.1
Pancreas	PANC1005	10.4
Pancreas	PANC1	10.4
Pancreas	PATU8902	10.1
Pancreas	PATU8988S	9.5
Pancreas	PATU8988T	9.9
Pancreas	PK1	9.9
Pancreas	PK45H	10.3
Pancreas	PK59	9.8
Pancreas	PL45	10.3
Pancreas	PSN1	11.1
Pancreas	QGP1	10.1
Pancreas	SNU213	10.1
Pancreas	SNU324	11.6
Pancreas	SNU410	10.3
Pancreas	SU8686	9.9
Pancreas	SUIT2	10.1
Pancreas	SW1990	10.1
Pancreas	T3M4	9
Pancreas	TCCPAN2	10.2
Pancreas	YAPC	9.8
Pleura	ACCMESO1	9.4
Pleura	DM3	10.3
Pleura	ISTMES1	10.3
Pleura	ISTMES2	10.6
Pleura	JL1	10.5
Pleura	MPP89	9.8
Pleura	MSTO211H	10
Pleura	NCIH2052	9.6
Pleura	NCIH2452	10
Pleura	NCIH28	10.8
Prostate	22RV1	9.5
Prostate	DU145	9.8
Prostate	LNCAPCLONEFGC	9.1
Prostate	MDAPCA2B	9.9
Prostate	NCIH660	10.3
Prostate	PC3	10.5
Prostate	VCAP	9.8
Salivary gland	A253	7.7
Salivary gland	YD15	9.2
Skin	A101D	10.7
Skin	A2058	11.1
Skin	A375	11.8
Skin	C32	10.5
Skin	CHL1	9.8
Skin	CJM	10.4
Skin	COLO679	10.8
Skin	COLO741	10.6
Skin	COLO783	10.3
Skin	COLO792	10.8
Skin	COLO800	11
Skin	COLO818	10.5
Skin	COLO829	11.4
Skin	COLO849	11
Skin	G361	9.8
Skin	GRM	11.9
Skin	HMCB	10.4
Skin	HS294T	10.8
Skin	HS600T	9.9
Skin	HS688AT	9.9
Skin	HS695T	11
Skin	HS839T	9.6
Skin	HS852T	10.3
Skin	HS895T	10.3
Skin	HS934T	9.6
Skin	HS936T	10.9
Skin	HS939T	10.8
Skin	HS940T	10.3
Skin	HS944T	11.4
Skin	HT144	10.5
Skin	IGR1	10.4
Skin	IGR37	10.3
Skin	IGR39	10
Skin	IPC298	10.6
Skin	K029AX	10.2
Skin	LOXIMVI	10.5
Skin	MALME3M	10.1
Skin	MDAMB435S	9.7
Skin	MELHO	11.2
Skin	MELJUSO	10.5
Skin	MEWO	10.2
Skin	RPMI7951	10.7
Skin	RVH421	10.3
Skin	SH4	10.4
Skin	SKMEL1	10.6
Skin	SKMEL24	10.8
Skin	SKMEL28	10.1
Skin	SKMEL2	10.6
Skin	SKMEL30	10.8
Skin	SKMEL31	11
Skin	SKMEL3	10.4
Skin	SKMEL5	10.2
Skin	UACC257	10.1
Skin	UACC62	11
Skin	WM115	11.3
Skin	WM1799	10.2
Skin	WM2664	11.6
Skin	WM793	10.3
Skin	WM88	10.2
Skin	WM983B	10
Small intestine	HUTU80	9.8
Soft tissue	A204	9.3
Soft tissue	G401	9.5
Soft tissue	G402	9.7
Soft tissue	GCT	10.4
Soft tissue	HS729	10.9
Soft tissue	HT1080	10.6
Soft tissue	KYM1	8.4
Soft tissue	MESSA	9.5
Soft tissue	RD	11.1
Soft tissue	RH30	11
Soft tissue	RH41	10.7
Soft tissue	RKN	11.6
Soft tissue	S117	10.4
Soft tissue	SJRH30	10.4
Soft tissue	SKLMS1	11.2
Soft tissue	SKUT1	9.7
Soft tissue	TE125T	9.4
Soft tissue	TE159T	9.6
Soft tissue	TE441T	9.8
Soft tissue	TE617T	9.3
Stomach	2313287	10.5
Stomach	AGS	9.7
Stomach	AZ521	9.2
Stomach	ECC10	9.7
Stomach	ECC12	11.2
Stomach	FU97	9.6
Stomach	GCIY	9.8
Stomach	GSS	9.6
Stomach	GSU	10.7
Stomach	HGC27	9
Stomach	HS746T	10.7
Stomach	HUG1N	9.6
Stomach	IM95	9.9
Stomach	KATOIII	9.8
Stomach	KE39	10
Stomach	LMSU	10
Stomach	MKN1	9.3
Stomach	MKN45	10.2
Stomach	MKN74	9.7
Stomach	MKN7	9.5
Stomach	NCCSTCK140	8.7
Stomach	NCIN87	10.5
Stomach	NUGC2	10.1
Stomach	NUGC3	9.8
Stomach	NUGC4	10
Stomach	OCUM1	10.8
Stomach	RERFGC1B	9.5
Stomach	SH10TC	9.9
Stomach	SNU16	10.7
Stomach	SNU1	9.1
Stomach	SNU216	10
Stomach	SNU520	10.3
Stomach	SNU5	9.5
Stomach	SNU601	10.2
Stomach	SNU620	10.2
Stomach	SNU668	9.8
Stomach	SNU719	11.1
Stomach	TGBC11TKB	9.5
Thyroid	8305C	10.7
Thyroid	8505C	9.6
Thyroid	BCPAP	11
Thyroid	BHT101	10.5
Thyroid	CAL62	9.8
Thyroid	CGTHW1	10.1
Thyroid	FTC133	10.1
Thyroid	FTC238	9.2
Thyroid	ML1	10.2
Thyroid	SW579	10.6
Thyroid	TT2609C02	10.7
Thyroid	TT	10.5
Upper aerodigestive tract	BHY	9.7
Upper aerodigestive tract	BICR16	9.7
Upper aerodigestive tract	BICR18	8.9
Upper aerodigestive tract	BICR22	9.7
Upper aerodigestive tract	BICR31	9.1
Upper aerodigestive tract	BICR56	9.7
Upper aerodigestive tract	BICR6	9.5
Upper aerodigestive tract	CAL27	9.4
Upper aerodigestive tract	CAL33	10
Upper aerodigestive tract	DETROIT562	8.6
Upper aerodigestive tract	FADU	8.8
Upper aerodigestive tract	HS840T	10.3
Upper aerodigestive tract	HSC2	9.1
Upper aerodigestive tract	HSC3	9.8
Upper aerodigestive tract	HSC4	8.4
Upper aerodigestive tract	PECAPJ15	9.6
Upper aerodigestive tract	PECAPJ34CLONEC12	9.2
Upper aerodigestive tract	PECAPJ41CLONED2	9.3
Upper aerodigestive tract	PECAPJ49	9.6
Upper aerodigestive tract	SCC15	9.9
Upper aerodigestive tract	SCC25	9.7
Upper aerodigestive tract	SCC4	10
Upper aerodigestive tract	SCC9	9.4
Upper aerodigestive tract	SNU1076	10
Upper aerodigestive tract	SNU1214	8.9
Upper aerodigestive tract	SNU46	9.5
Upper aerodigestive tract	SNU899	9.6
Upper aerodigestive tract	YD10B	9.2
Upper aerodigestive tract	YD38	10.3
Upper aerodigestive tract	YD8	10.1
Urinary tract	5637	10.7
Urinary tract	639V	9.8
Urinary tract	647V	9.3
Urinary tract	BC3C	9.1
Urinary tract	BFTC905	9.4
Urinary tract	CAL29	9.2
Urinary tract	HS172T	10
Urinary tract	HT1197	9.9
Urinary tract	HT1376	10
Urinary tract	J82	9.9
Urinary tract	JMSU1	11.3
Urinary tract	KMBC2	9.6
Urinary tract	KU1919	10.3
Urinary tract	RT11284	9.7
Urinary tract	RT112	9.9
Urinary tract	RT4	9.7
Urinary tract	SCABER	9.2
Urinary tract	SW1710	10
Urinary tract	SW780	9.8
Urinary tract	T24	10.3
Urinary tract	TCCSUP	11.8
Urinary tract	UMUC1	9.5
Urinary tract	UMUC3	10.4
Urinary tract	VMCUB1	9.7

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	80.4
Adrenal gland	63.8
Appendix	73.9
Bone marrow	31.7
Breast	42.7
Cerebral cortex	54
Cervix, uterine	61.3
Colon	32.2
Duodenum	26.9
Endometrium	78.5
Epididymis	33.4
Esophagus	47
Fallopian tube	66.8
Gallbladder	77.8
Heart muscle	41.3
Kidney	40.2
Liver	26.4
Lung	59.3
Lymph node	34.6
Ovary	58.1
Pancreas	10.8
Parathyroid gland	42.5
Placenta	65.8
Prostate	45.2
Rectum	31.1
Salivary gland	13.3
Seminal vesicle	61.9
Skeletal muscle	12.1
Skin	27
Small intestine	32
Smooth muscle	86.6
Spleen	71.7
Stomach	33.1
Testis	71.6
Thyroid gland	68.4
Tonsil	22.6
Urinary bladder	48.1

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
24260522	Overexpression	Glioblastoma	The most striking differences were upregulation of EZH2, PHF19, CBX8 and PHC2 and downregulation of CBX7, CBX6, EZH1 and RYBP.

Summary
Symbol	PHC2
Name	polyhomeotic homolog 2
Aliases	EDR2; early development regulator 2 (homolog of polyhomeotic 2); polyhomeotic-like 2 (Drosophila); early dev ......
Location	1p35.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.344	1.23e-12	18.8	64.1	17.1	Neutral
BRCA	Breast invasive carcinoma	1075	0.536	4.96e-81	33	56.5	10.5	Neutral
CESC	Cervical and endocervical cancers	292	0.314	4.39e-08	6.8	64.7	28.4	Neutral
COAD	Colon adenocarcinoma	449	0.534	1.95e-34	29.8	66.4	3.8	Neutral
ESCA	Esophageal carcinoma	183	0.465	3.17e-11	31.7	52.5	15.8	Neutral
GBM	Glioblastoma multiforme	147	0.364	5.69e-06	8.8	72.8	18.4	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.389	4.64e-20	14.8	72.2	13	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.485	2.28e-32	16.8	81.5	1.7	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.414	2.26e-13	16	84	0	Neutral
LAML	Acute Myeloid Leukemia	166	0.068	0.382	0	97.6	2.4	Neutral
LGG	Brain Lower Grade Glioma	513	0.671	1.99e-68	36.3	61	2.7	Loss
LIHC	Liver hepatocellular carcinoma	364	0.449	1.85e-19	34.1	58.8	7.1	Loss
LUAD	Lung adenocarcinoma	512	0.374	1.9e-18	20.7	54.9	24.4	Neutral
LUSC	Lung squamous cell carcinoma	498	0.589	7.81e-48	38.6	49.2	12.2	Loss
OV	Ovarian serous cystadenocarcinoma	300	0.689	1.68e-43	24.3	41.3	34.3	Gain
PAAD	Pancreatic adenocarcinoma	177	0.367	4.95e-07	26	68.4	5.6	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.623	8.75e-19	61.7	36.4	1.9	Loss
PRAD	Prostate adenocarcinoma	491	0.276	4.58e-10	7.9	90.6	1.4	Neutral
READ	Rectum adenocarcinoma	164	0.578	5.66e-16	35.4	60.4	4.3	Loss
SARC	Sarcoma	255	0.582	1.73e-24	14.1	58	27.8	Neutral
SKCM	Skin Cutaneous Melanoma	367	0.453	5.3e-20	16.3	61.9	21.8	Neutral
STAD	Stomach adenocarcinoma	413	0.26	8.29e-08	19.9	70.2	9.9	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.007	0.934	16	62	22	Neutral
THCA	Thyroid carcinoma	497	0.14	0.00172	0.8	98.8	0.4	Neutral
THYM	Thymoma	119	0.275	0.0025	5.9	93.3	0.8	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.321	2.44e-14	9.3	80.8	9.9	Neutral

Summary
Symbol	PHC2
Name	polyhomeotic homolog 2
Aliases	EDR2; early development regulator 2 (homolog of polyhomeotic 2); polyhomeotic-like 2 (Drosophila); early dev ......
Location	1p35.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.377	6.6e-16	17	408	-0.085	0.056	NS/NA
BRCA	Breast invasive carcinoma	-0.32	0	83	785	0.293	3.22e-69	Increased
CESC	Cervical and endocervical cancers	-0.478	0	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.367	2.36e-11	19	297	-0.162	1.63e-11	NS/NA
ESCA	Esophageal carcinoma	-0.401	9.04e-09	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.18	0.151	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.428	0	20	522	0.099	4.07e-07	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.275	2.64e-07	24	319	-0.117	2.03e-07	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.247	1.7e-05	23	275	0.263	6.39e-24	Increased
LAML	Acute Myeloid Leukemia	-0.104	0.176	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.504	0	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.174	0.000382	41	373	0	0.342	NS/NA
LUAD	Lung adenocarcinoma	-0.395	0	21	456	-0.099	5.62e-12	NS/NA
LUSC	Lung squamous cell carcinoma	-0.621	0	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.733	0.0311	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.163	0.0273	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.423	2.29e-09	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.222	2.39e-07	35	498	0.163	2.34e-11	NS/NA
READ	Rectum adenocarcinoma	-0.524	3.1e-08	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.243	7.32e-05	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.448	0	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.19	0.000228	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.24	0.00263	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.44	0	50	509	-0.091	1.23e-06	NS/NA
THYM	Thymoma	-0.32	0.000356	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.178	0.000114	34	431	0.126	3.18e-10	NS/NA

Summary
Symbol	PHC2
Name	polyhomeotic homolog 2
Aliases	EDR2; early development regulator 2 (homolog of polyhomeotic 2); polyhomeotic-like 2 (Drosophila); early dev ......
Location	1p35.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	2	Medium
Appendix	2	Medium
Bone marrow	1	Low
Breast	2	Medium
Bronchus	2	Medium
Caudate	3	High
Cerebellum	2	Medium
Cerebral cortex	3	High
Cervix, uterine	2	Medium
Colon	2	Medium
Duodenum	2	Medium
Endometrium	2	Medium
Epididymis	2	Medium
Esophagus	2	Medium
Fallopian tube	3	High
Gallbladder	2	Medium
Heart muscle	2	Medium
Hippocampus	2	Medium
Kidney	3	High
Liver	2	Medium
Lung	2	Medium
Lymph node	2	Medium
Nasopharynx	2	Medium
Oral mucosa	2	Medium
Ovary	2	Medium
Pancreas	2	Medium
Parathyroid gland	2	Medium
Placenta	2	Medium
Prostate	3	High
Rectum	2	Medium
Salivary gland	2	Medium
Seminal vesicle	2	Medium
Skeletal muscle	2	Medium
Skin	2	Medium
Small intestine	2	Medium
Smooth muscle	2	Medium
Soft tissue	2	Medium
Spleen	2	Medium
Stomach	2	Medium
Testis	2	Medium
Thyroid gland	3	High
Tonsil	2	Medium
Urinary bladder	3	High
Vagina	2	Medium

Summary
Symbol	PHC2
Name	polyhomeotic homolog 2
Aliases	EDR2; early development regulator 2 (homolog of polyhomeotic 2); polyhomeotic-like 2 (Drosophila); early dev ......
Location	1p35.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.173	NS	24476821
BRCA	Breast invasive carcinoma	521	4.39e-14	Significant	23000897
COAD	Colon adenocarcinoma	149	0.0702	NS	22810696
GBM	Glioblastoma multiforme	157	0.00999	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	5.44e-20	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.139	NS	26536169
LGG	Brain Lower Grade Glioma	513	6.24e-52	Significant	26824661
LUAD	Lung adenocarcinoma	230	8.88e-05	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	3.24e-16	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.00421	Significant	21720365
PRAD	Prostate adenocarcinoma	333	9.89e-15	Significant	26544944
READ	Rectum adenocarcinoma	67	0.272	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.239	NS	26091043
STAD	Stomach adenocarcinoma	277	0.0662	NS	25079317
THCA	Thyroid carcinoma	391	0.0322	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.0311	Significant	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	0.852	0.439	NS
BRCA	Breast invasive carcinoma	1079	0.781	0.282	NS
CESC	Cervical and endocervical cancers	291	1.413	0.305	NS
COAD	Colon adenocarcinoma	439	0.892	0.688	NS
ESCA	Esophageal carcinoma	184	0.561	0.0737	NS
GBM	Glioblastoma multiforme	158	0.973	0.898	NS
HNSC	Head and Neck squamous cell carcinoma	518	1.42	0.0741	NS
KIRC	Kidney renal clear cell carcinoma	531	1.877	0.00254	Shorter
KIRP	Kidney renal papillary cell carcinoma	287	0.946	0.888	NS
LAML	Acute Myeloid Leukemia	149	1.106	0.733	NS
LGG	Brain Lower Grade Glioma	511	2.564	0.000596	Shorter
LIHC	Liver hepatocellular carcinoma	365	1.848	0.0162	Shorter
LUAD	Lung adenocarcinoma	502	1.176	0.435	NS
LUSC	Lung squamous cell carcinoma	494	1.248	0.239	NS
OV	Ovarian serous cystadenocarcinoma	303	1.041	0.849	NS
PAAD	Pancreatic adenocarcinoma	177	1.103	0.744	NS
PCPG	Pheochromocytoma and Paraganglioma	179	0.369	0.402	NS
PRAD	Prostate adenocarcinoma	497	1.452	0.682	NS
READ	Rectum adenocarcinoma	159	1.478	0.501	NS
SARC	Sarcoma	259	1.436	0.233	NS
SKCM	Skin Cutaneous Melanoma	459	0.986	0.941	NS
STAD	Stomach adenocarcinoma	388	1.057	0.809	NS
TGCT	Testicular Germ Cell Tumors	134	1165391095.731	0.25	NS
THCA	Thyroid carcinoma	500	0.693	0.713	NS
THYM	Thymoma	119	0.249	0.179	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	0.808	0.48	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	0.054	0.28	NS
BRCA	Breast invasive carcinoma	1071	-0.018	0.562	NS
CESC	Cervical and endocervical cancers	167	-0.107	0.17	NS
COAD	Colon adenocarcinoma	445	0.018	0.711	NS
ESCA	Esophageal carcinoma	162	-0.048	0.543	NS
HNSC	Head and Neck squamous cell carcinoma	448	0.124	0.00853	Higher
KIRC	Kidney renal clear cell carcinoma	531	0.085	0.0502	NS
KIRP	Kidney renal papillary cell carcinoma	260	-0.024	0.697	NS
LIHC	Liver hepatocellular carcinoma	347	0.026	0.624	NS
LUAD	Lung adenocarcinoma	507	0.04	0.374	NS
LUSC	Lung squamous cell carcinoma	497	-0.036	0.419	NS
OV	Ovarian serous cystadenocarcinoma	302	-0.024	0.677	NS
PAAD	Pancreatic adenocarcinoma	176	-0.006	0.94	NS
READ	Rectum adenocarcinoma	156	0.029	0.72	NS
SKCM	Skin Cutaneous Melanoma	410	-0.003	0.949	NS
STAD	Stomach adenocarcinoma	392	-0.055	0.276	NS
TGCT	Testicular Germ Cell Tumors	81	0.229	0.0399	Higher
THCA	Thyroid carcinoma	499	0.057	0.205	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.044	0.324	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	0.07	0.248	NS
HNSC	Head and Neck squamous cell carcinoma	498	0.109	0.0149	Higher
KIRC	Kidney renal clear cell carcinoma	525	0.042	0.341	NS
LGG	Brain Lower Grade Glioma	514	0.225	2.67e-07	Higher
LIHC	Liver hepatocellular carcinoma	366	0.07	0.182	NS
OV	Ovarian serous cystadenocarcinoma	296	0.017	0.768	NS
PAAD	Pancreatic adenocarcinoma	176	0.043	0.568	NS
STAD	Stomach adenocarcinoma	406	0.027	0.588	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.13	0.00257	Higher

Summary
Symbol	PHC2
Name	polyhomeotic homolog 2
Aliases	EDR2; early development regulator 2 (homolog of polyhomeotic 2); polyhomeotic-like 2 (Drosophila); early dev ......
Location	1p35.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	PHC2
Name	polyhomeotic homolog 2
Aliases	EDR2; early development regulator 2 (homolog of polyhomeotic 2); polyhomeotic-like 2 (Drosophila); early dev ......
Location	1p35.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for PHC2.

Summary
Symbol	PHC2
Name	polyhomeotic homolog 2
Aliases	EDR2; early development regulator 2 (homolog of polyhomeotic 2); polyhomeotic-like 2 (Drosophila); early dev ......
Location	1p35.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining [ TOP ]
There is no record for PHC2.