CR2Cancer

Summary
Symbol	PHF2
Name	PHD finger protein 2
Aliases	KIAA0662; JHDM1E; CENP-35; jumonji C domain-containing histone demethylase 1E; centromere protein 35; GRC5; ......
Location	9q22.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

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Domain

PF02373 JmjC domain
PF00628 PHD-finger

Function

Lysine demethylase that demethylates both histones and non-histone proteins. Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B. Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA.

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification erase	Histone methylation	H3K9me2	H3K9	21532585

> Gene Ontology [ TOP ]
Biological Process	GO:0000183 chromatin silencing at rDNA GO:0001889 liver development GO:0006342 chromatin silencing GO:0006482 protein demethylation GO:0008214 protein dealkylation GO:0016458 gene silencing GO:0016570 histone modification GO:0016577 histone demethylation GO:0031935 regulation of chromatin silencing GO:0031936 negative regulation of chromatin silencing GO:0033169 histone H3-K9 demethylation GO:0040029 regulation of gene expression, epigenetic GO:0045814 negative regulation of gene expression, epigenetic GO:0045815 positive regulation of gene expression, epigenetic GO:0048732 gland development GO:0060968 regulation of gene silencing GO:0060969 negative regulation of gene silencing GO:0061008 hepaticobiliary system development GO:0061187 regulation of chromatin silencing at rDNA GO:0061188 negative regulation of chromatin silencing at rDNA GO:0070076 histone lysine demethylation GO:0070988 demethylation GO:1902275 regulation of chromatin organization GO:1905268 negative regulation of chromatin organization
Molecular Function	GO:0003713 transcription coactivator activity GO:0005506 iron ion binding GO:0032451 demethylase activity GO:0032452 histone demethylase activity GO:0032454 histone demethylase activity (H3-K9 specific) GO:0035064 methylated histone binding GO:0042393 histone binding GO:0051213 dioxygenase activity
Cellular Component	GO:0000775 chromosome, centromeric region GO:0000776 kinetochore GO:0000777 condensed chromosome kinetochore GO:0000779 condensed chromosome, centromeric region GO:0000793 condensed chromosome GO:0098687 chromosomal region

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-3214842: HDMs demethylate histones

Summary
Symbol	PHF2
Name	PHD finger protein 2
Aliases	KIAA0662; JHDM1E; CENP-35; jumonji C domain-containing histone demethylase 1E; centromere protein 35; GRC5; ......
Location	9q22.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM456270	c.372C>T	p.T124T	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM305500	c.2961_2962ins15	p.T987_P988insPASTT	Insertion - In frame	Large_intestine
COSM3659719	c.2279C>T	p.S760L	Substitution - Missense	Skin
COSM1111294	c.639G>T	p.K213N	Substitution - Missense	Endometrium
COSM4164138	c.1435A>C	p.T479P	Substitution - Missense	Thyroid
COSM5789553	c.893A>G	p.Q298R	Substitution - Missense	Breast
COSM3659716	c.2001G>A	p.E667E	Substitution - coding silent	Skin
COSM2732578	c.234C>T	p.D78D	Substitution - coding silent	Central_nervous_system
COSM2732605	c.1433C>T	p.A478V	Substitution - Missense	Large_intestine
COSM1111297	c.1645G>A	p.E549K	Substitution - Missense	Endometrium
COSM1173530	c.1724C>T	p.P575L	Substitution - Missense	Oesophagus
COSM198796	c.1468delA	p.K492fs*6	Deletion - Frameshift	Large_intestine
COSM297068	c.2961C>A	p.T987T	Substitution - coding silent	Lung
COSM305500	c.2961_2962ins15	p.T987_P988insPASTT	Insertion - In frame	Upper_aerodigestive_tract
COSM1463726	c.824C>T	p.S275L	Substitution - Missense	Large_intestine
COSM3747772	c.2992A>C	p.T998P	Substitution - Missense	Thyroid
COSM4801375	c.503A>C	p.K168T	Substitution - Missense	Liver
COSM297068	c.2961C>A	p.T987T	Substitution - coding silent	Thyroid
COSM1625263	c.2401A>G	p.M801V	Substitution - Missense	Liver
COSM233098	c.296C>T	p.P99L	Substitution - Missense	Skin
COSM5633232	c.2037C>T	p.Y679Y	Substitution - coding silent	Oesophagus
COSM3747771	c.2990G>C	p.S997T	Substitution - Missense	Thyroid
COSM3723034	c.2976C>A	p.T992T	Substitution - coding silent	Kidney
COSM4139691	c.2194G>A	p.D732N	Substitution - Missense	Lung
COSM4007303	c.309C>T	p.D103D	Substitution - coding silent	Thyroid
COSM295171	c.720C>T	p.C240C	Substitution - coding silent	Endometrium
COSM1111296	c.1368C>T	p.V456V	Substitution - coding silent	Endometrium
COSM1191882	c.1613C>A	p.A538D	Substitution - Missense	Central_nervous_system
COSM198796	c.1468delA	p.K492fs*6	Deletion - Frameshift	Stomach
COSM198796	c.1468delA	p.K492fs*6	Deletion - Frameshift	Pancreas
COSM198796	c.1468delA	p.K492fs*6	Deletion - Frameshift	Large_intestine
COSM4477741	c.217C>T	p.P73S	Substitution - Missense	Skin
COSM198796	c.1468delA	p.K492fs*6	Deletion - Frameshift	Prostate
COSM198796	c.1468delA	p.K492fs*6	Deletion - Frameshift	Breast
COSM198796	c.1468delA	p.K492fs*6	Deletion - Frameshift	Biliary_tract
COSM4487286	c.3168C>T	p.S1056S	Substitution - coding silent	Skin
COSM1111293	c.549C>T	p.S183S	Substitution - coding silent	Endometrium
COSM4713970	c.804C>G	p.F268L	Substitution - Missense	Large_intestine
COSM305500	c.2961_2962ins15	p.T987_P988insPASTT	Insertion - In frame	Large_intestine
COSM1625264	c.2899T>G	p.S967A	Substitution - Missense	Liver
COSM2732614	c.1716G>T	p.L572L	Substitution - coding silent	Skin
COSM2732633	c.2851delA	p.K953fs*7	Deletion - Frameshift	Large_intestine
COSM3670074	c.2334G>T	p.E778D	Substitution - Missense	Liver
COSM4886656	c.817C>A	p.P273T	Substitution - Missense	Upper_aerodigestive_tract
COSM5424012	c.2587C>A	p.Q863K	Substitution - Missense	Prostate
COSM3750192	c.2964G>T	p.P988P	Substitution - coding silent	Large_intestine
COSM3747771	c.2990G>C	p.S997T	Substitution - Missense	Thyroid
COSM1463732	c.1774C>T	p.R592*	Substitution - Nonsense	Large_intestine
COSM4466264	c.1424C>T	p.P475L	Substitution - Missense	Skin
COSM305500	c.2961_2962ins15	p.T987_P988insPASTT	Insertion - In frame	Large_intestine
COSM1220356	c.1498C>A	p.P500T	Substitution - Missense	Large_intestine
COSM3413843	c.420G>A	p.P140P	Substitution - coding silent	Large_intestine
COSM1220355	c.1477A>G	p.T493A	Substitution - Missense	Stomach
COSM1463736	c.2850_2851insAA	p.S954fs*7	Insertion - Frameshift	Large_intestine
COSM753850	c.2730C>T	p.V910V	Substitution - coding silent	Skin
COSM3943115	c.3274G>A	p.G1092R	Substitution - Missense	Oesophagus
COSM1241576	c.159T>C	p.C53C	Substitution - coding silent	Oesophagus
COSM305500	c.2961_2962ins15	p.T987_P988insPASTT	Insertion - In frame	Large_intestine
COSM3413843	c.420G>A	p.P140P	Substitution - coding silent	Central_nervous_system
COSM1111305	c.2667T>C	p.F889F	Substitution - coding silent	Endometrium
COSM1220360	c.1204C>A	p.L402I	Substitution - Missense	Large_intestine
COSM5411507	c.494C>T	p.T165I	Substitution - Missense	Skin
COSM5890432	c.1196C>T	p.A399V	Substitution - Missense	Skin
COSM3750192	c.2964G>T	p.P988P	Substitution - coding silent	Large_intestine
COSM3909076	c.1440G>A	p.P480P	Substitution - coding silent	Stomach
COSM1220355	c.1477A>G	p.T493A	Substitution - Missense	Stomach
COSM3699794	c.2094C>T	p.N698N	Substitution - coding silent	Large_intestine
COSM1463735	c.2850_2851insA	p.S954fs*9	Insertion - Frameshift	Large_intestine
COSM4890491	c.2727G>T	p.R909S	Substitution - Missense	Upper_aerodigestive_tract
COSM3750192	c.2964G>T	p.P988P	Substitution - coding silent	Large_intestine
COSM5718394	c.442G>C	p.D148H	Substitution - Missense	Skin
COSM1111298	c.1740T>G	p.V580V	Substitution - coding silent	Endometrium
COSM3716319	c.1969G>T	p.G657C	Substitution - Missense	Upper_aerodigestive_tract
COSM3723034	c.2976C>A	p.T992T	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM1643903	c.833T>C	p.I278T	Substitution - Missense	Stomach
COSM305500	c.2961_2962ins15	p.T987_P988insPASTT	Insertion - In frame	Large_intestine
COSM3670074	c.2334G>T	p.E778D	Substitution - Missense	Liver
COSM1701346	c.325C>T	p.P109S	Substitution - Missense	Skin
COSM305500	c.2961_2962ins15	p.T987_P988insPASTT	Insertion - In frame	Upper_aerodigestive_tract
COSM326139	c.3161G>A	p.R1054Q	Substitution - Missense	Lung
COSM1111302	c.2193T>C	p.D731D	Substitution - coding silent	Endometrium
COSM305500	c.2961_2962ins15	p.T987_P988insPASTT	Insertion - In frame	Large_intestine
COSM305500	c.2961_2962ins15	p.T987_P988insPASTT	Insertion - In frame	Upper_aerodigestive_tract
COSM2732580	c.353T>C	p.M118T	Substitution - Missense	Large_intestine
COSM4444176	c.692C>A	p.P231H	Substitution - Missense	Large_intestine
COSM5788374	c.1291C>G	p.L431V	Substitution - Missense	Breast
COSM3909080	c.2038G>A	p.V680M	Substitution - Missense	Stomach
COSM1111292	c.448G>A	p.E150K	Substitution - Missense	Endometrium
COSM3699793	c.873C>T	p.S291S	Substitution - coding silent	Large_intestine
COSM3723035	c.2955T>C	p.S985S	Substitution - coding silent	Thyroid
COSM4611878	c.1467_1468insA	p.T493fs*21	Insertion - Frameshift	Large_intestine
COSM753852	c.851G>T	p.W284L	Substitution - Missense	Lung
COSM276727	c.1901A>C	p.K634T	Substitution - Missense	Large_intestine
COSM305500	c.2961_2962ins15	p.T987_P988insPASTT	Insertion - In frame	Central_nervous_system
COSM3909084	c.2804C>T	p.A935V	Substitution - Missense	Stomach
COSM1111306	c.2682G>T	p.K894N	Substitution - Missense	Endometrium
COSM2732586	c.741C>T	p.D247D	Substitution - coding silent	Central_nervous_system
COSM1625264	c.2899T>G	p.S967A	Substitution - Missense	Liver
COSM1220356	c.1498C>A	p.P500T	Substitution - Missense	Stomach
COSM198796	c.1468delA	p.K492fs*6	Deletion - Frameshift	Prostate
COSM2732605	c.1433C>T	p.A478V	Substitution - Missense	Large_intestine
COSM80332	c.936C>T	p.T312T	Substitution - coding silent	Ovary
COSM3750192	c.2964G>T	p.P988P	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM1220356	c.1498C>A	p.P500T	Substitution - Missense	Large_intestine
COSM1111302	c.2193T>C	p.D731D	Substitution - coding silent	Stomach
COSM3413844	c.1267C>T	p.P423S	Substitution - Missense	Central_nervous_system
COSM305500	c.2961_2962ins15	p.T987_P988insPASTT	Insertion - In frame	Large_intestine
COSM3358380	c.378C>T	p.P126P	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM2732633	c.2851delA	p.K953fs*7	Deletion - Frameshift	Large_intestine
COSM305500	c.2961_2962ins15	p.T987_P988insPASTT	Insertion - In frame	Large_intestine
COSM3747772	c.2992A>C	p.T998P	Substitution - Missense	Liver
COSM3750192	c.2964G>T	p.P988P	Substitution - coding silent	Lung
COSM4164137	c.1032G>T	p.M344I	Substitution - Missense	Thyroid
COSM4935546	c.569T>A	p.L190H	Substitution - Missense	Liver
COSM4569639	c.1908T>G	p.S636S	Substitution - coding silent	Skin
COSM3750192	c.2964G>T	p.P988P	Substitution - coding silent	Large_intestine
COSM1319564	c.324G>A	p.V108V	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM1111295	c.848G>A	p.R283H	Substitution - Missense	Large_intestine
COSM5499857	c.602+6T>C	p.?	Unknown	Biliary_tract
COSM3750192	c.2964G>T	p.P988P	Substitution - coding silent	Large_intestine
COSM3433363	c.3269G>A	p.R1090Q	Substitution - Missense	Large_intestine
COSM334956	c.3162G>T	p.R1054R	Substitution - coding silent	Lung
COSM233098	c.296C>T	p.P99L	Substitution - Missense	Skin
COSM5826522	c.2955_2956ins15	p.T996_S997insTPAST	Insertion - In frame	Large_intestine
COSM4618887	c.419C>T	p.P140L	Substitution - Missense	Large_intestine
COSM3723034	c.2976C>A	p.T992T	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM1187769	c.2436G>T	p.Q812H	Substitution - Missense	Lung
COSM3723034	c.2976C>A	p.T992T	Substitution - coding silent	Large_intestine
COSM305500	c.2961_2962ins15	p.T987_P988insPASTT	Insertion - In frame	Large_intestine
COSM4713968	c.460+2T>C	p.?	Unknown	Large_intestine
COSM5998284	c.874G>A	p.E292K	Substitution - Missense	Prostate
COSM3723035	c.2955T>C	p.S985S	Substitution - coding silent	Kidney
COSM1625263	c.2401A>G	p.M801V	Substitution - Missense	Liver
COSM4971766	c.461-1G>A	p.?	Unknown	Central_nervous_system
COSM305500	c.2961_2962ins15	p.T987_P988insPASTT	Insertion - In frame	Upper_aerodigestive_tract
COSM1331438	c.3038C>T	p.P1013L	Substitution - Missense	Ovary
COSM5826522	c.2955_2956ins15	p.T996_S997insTPAST	Insertion - In frame	Large_intestine
COSM397914	c.110T>C	p.V37A	Substitution - Missense	Lung
COSM3723034	c.2976C>A	p.T992T	Substitution - coding silent	Thyroid
COSM422311	c.615C>T	p.F205F	Substitution - coding silent	Stomach
COSM753853	c.310G>C	p.V104L	Substitution - Missense	Lung
COSM298373	c.281G>A	p.R94Q	Substitution - Missense	Large_intestine
COSM366729	c.141A>T	p.I47I	Substitution - coding silent	Lung
COSM4164139	c.1795T>G	p.S599A	Substitution - Missense	Thyroid
COSM198796	c.1468delA	p.K492fs*6	Deletion - Frameshift	Large_intestine
COSM1463735	c.2850_2851insA	p.S954fs*9	Insertion - Frameshift	Large_intestine
COSM305500	c.2961_2962ins15	p.T987_P988insPASTT	Insertion - In frame	Upper_aerodigestive_tract
COSM3659711	c.388C>T	p.P130S	Substitution - Missense	Skin
COSM138718	c.1415C>T	p.P472L	Substitution - Missense	Skin
COSM4747649	c.3241delA	p.R1081fs*6	Deletion - Frameshift	Stomach
COSM5684279	c.3096C>T	p.F1032F	Substitution - coding silent	Soft_tissue
COSM4164140	c.2940C>T	p.S980S	Substitution - coding silent	Thyroid
COSM305500	c.2961_2962ins15	p.T987_P988insPASTT	Insertion - In frame	Large_intestine
COSM1644889	c.443A>G	p.D148G	Substitution - Missense	Salivary_gland
COSM305500	c.2961_2962ins15	p.T987_P988insPASTT	Insertion - In frame	Upper_aerodigestive_tract
COSM1220358	c.1559C>T	p.T520M	Substitution - Missense	Large_intestine
COSM3750192	c.2964G>T	p.P988P	Substitution - coding silent	Large_intestine
COSM5747022	c.1346T>C	p.V449A	Substitution - Missense	Pancreas
COSM5459454	c.574G>A	p.V192I	Substitution - Missense	Large_intestine
COSM3659718	c.2259C>T	p.V753V	Substitution - coding silent	Skin
COSM4929225	c.709T>G	p.C237G	Substitution - Missense	Liver
COSM4139020	c.2946G>C	p.T982T	Substitution - coding silent	Thyroid
COSM4417122	c.789+6C>T	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM1463732	c.1774C>T	p.R592*	Substitution - Nonsense	Breast
COSM4921060	c.2431C>T	p.L811L	Substitution - coding silent	Liver
COSM377771	c.2088G>C	p.K696N	Substitution - Missense	Lung
COSM4149566	c.3015G>T	p.Q1005H	Substitution - Missense	Ovary
COSM4713969	c.738C>T	p.T246T	Substitution - coding silent	Large_intestine
COSM1736326	c.2252C>G	p.A751G	Substitution - Missense	Central_nervous_system
COSM305500	c.2961_2962ins15	p.T987_P988insPASTT	Insertion - In frame	Large_intestine
COSM4139019	c.763G>A	p.A255T	Substitution - Missense	Kidney
COSM1463729	c.1345G>A	p.V449I	Substitution - Missense	Large_intestine
COSM246564	c.2620G>A	p.D874N	Substitution - Missense	Prostate
COSM5064167	c.2731G>A	p.G911S	Substitution - Missense	Stomach
COSM297068	c.2961C>A	p.T987T	Substitution - coding silent	Large_intestine
COSM2732625	c.2309C>T	p.A770V	Substitution - Missense	Large_intestine
COSM5455810	c.2450C>A	p.A817D	Substitution - Missense	Large_intestine
COSM305500	c.2961_2962ins15	p.T987_P988insPASTT	Insertion - In frame	Large_intestine
COSM4139020	c.2946G>C	p.T982T	Substitution - coding silent	Kidney
COSM3927264	c.1911T>A	p.F637L	Substitution - Missense	Skin
COSM1686590	c.1329+1G>A	p.?	Unknown	Skin
COSM298373	c.281G>A	p.R94Q	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM396351	c.2676G>T	p.R892R	Substitution - coding silent	Lung
COSM5616167	c.2129A>T	p.K710M	Substitution - Missense	Lung
COSM3746109	c.2838G>A	p.E946E	Substitution - coding silent	Liver
COSM5826522	c.2955_2956ins15	p.T996_S997insTPAST	Insertion - In frame	Large_intestine
COSM5826522	c.2955_2956ins15	p.T996_S997insTPAST	Insertion - In frame	Large_intestine
COSM305500	c.2961_2962ins15	p.T987_P988insPASTT	Insertion - In frame	Large_intestine
COSM3723035	c.2955T>C	p.S985S	Substitution - coding silent	Thyroid
COSM1220353	c.854G>A	p.R285Q	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5592501	c.3213G>A	p.T1071T	Substitution - coding silent	Skin
COSM1463725	c.573C>T	p.N191N	Substitution - coding silent	Large_intestine
COSM305500	c.2961_2962ins15	p.T987_P988insPASTT	Insertion - In frame	Large_intestine
COSM1111295	c.848G>A	p.R283H	Substitution - Missense	Endometrium
COSM4713967	c.421G>T	p.A141S	Substitution - Missense	Large_intestine
COSM1111303	c.2563G>A	p.D855N	Substitution - Missense	Endometrium
COSM223348	c.1330-1G>A	p.?	Unknown	Skin
COSM305500	c.2961_2962ins15	p.T987_P988insPASTT	Insertion - In frame	Upper_aerodigestive_tract
COSM198796	c.1468delA	p.K492fs*6	Deletion - Frameshift	Large_intestine
COSM3909083	c.2790C>T	p.I930I	Substitution - coding silent	Stomach
COSM3750192	c.2964G>T	p.P988P	Substitution - coding silent	Lung
COSM1463730	c.1353G>A	p.P451P	Substitution - coding silent	Large_intestine
COSM4164140	c.2940C>T	p.S980S	Substitution - coding silent	Thyroid
COSM4915037	c.863C>G	p.S288C	Substitution - Missense	Liver
COSM326139	c.3161G>A	p.R1054Q	Substitution - Missense	Large_intestine
COSM118603	c.2610C>T	p.F870F	Substitution - coding silent	Ovary
COSM3716320	c.2453G>T	p.G818V	Substitution - Missense	Upper_aerodigestive_tract
COSM1463731	c.1419G>A	p.P473P	Substitution - coding silent	Large_intestine
COSM2732580	c.353T>C	p.M118T	Substitution - Missense	Large_intestine
COSM3723035	c.2955T>C	p.S985S	Substitution - coding silent	Thyroid
COSM5352128	c.2242G>A	p.G748S	Substitution - Missense	Kidney
COSM198796	c.1468delA	p.K492fs*6	Deletion - Frameshift	Large_intestine
COSM3659717	c.2162C>T	p.P721L	Substitution - Missense	Skin
COSM4837068	c.70G>C	p.D24H	Substitution - Missense	Cervix
COSM3723035	c.2955T>C	p.S985S	Substitution - coding silent	Kidney
COSM297068	c.2961C>A	p.T987T	Substitution - coding silent	Large_intestine
COSM5943093	c.2042_2043insG	p.D682fs*2	Insertion - Frameshift	Skin
COSM305500	c.2961_2962ins15	p.T987_P988insPASTT	Insertion - In frame	Large_intestine
COSM255626	c.1261G>C	p.E421Q	Substitution - Missense	Central_nervous_system
COSM198796	c.1468delA	p.K492fs*6	Deletion - Frameshift	Large_intestine
COSM1643903	c.833T>C	p.I278T	Substitution - Missense	Stomach
COSM305500	c.2961_2962ins15	p.T987_P988insPASTT	Insertion - In frame	Large_intestine
COSM2732609	c.1517C>A	p.P506H	Substitution - Missense	Large_intestine
COSM1220353	c.854G>A	p.R285Q	Substitution - Missense	Large_intestine
COSM4713972	c.2100G>A	p.P700P	Substitution - coding silent	Large_intestine
COSM3723034	c.2976C>A	p.T992T	Substitution - coding silent	Liver
COSM1220352	c.2099C>T	p.P700L	Substitution - Missense	Large_intestine
COSM3849113	c.3258G>A	p.L1086L	Substitution - coding silent	Breast
COSM4801375	c.503A>C	p.K168T	Substitution - Missense	Liver
COSM3750192	c.2964G>T	p.P988P	Substitution - coding silent	Large_intestine
COSM4830299	c.1249G>C	p.E417Q	Substitution - Missense	Cervix
COSM334955	c.2700C>T	p.D900D	Substitution - coding silent	Stomach
COSM3996693	c.811A>C	p.I271L	Substitution - Missense	Kidney
COSM297068	c.2961C>A	p.T987T	Substitution - coding silent	Upper_aerodigestive_tract
COSM305500	c.2961_2962ins15	p.T987_P988insPASTT	Insertion - In frame	Upper_aerodigestive_tract
COSM3659721	c.2673C>T	p.S891S	Substitution - coding silent	Skin
COSM1463734	c.2459C>T	p.A820V	Substitution - Missense	Large_intestine
COSM233098	c.296C>T	p.P99L	Substitution - Missense	Skin
COSM1636291	c.2833-3A>G	p.?	Unknown	Liver
COSM1220357	c.136G>A	p.D46N	Substitution - Missense	Large_intestine
COSM5497950	c.2703C>T	p.D901D	Substitution - coding silent	Biliary_tract
COSM4830585	c.270C>T	p.I90I	Substitution - coding silent	Cervix
COSM4398696	c.1421C>T	p.S474F	Substitution - Missense	Skin
COSM1111301	c.2080A>T	p.R694W	Substitution - Missense	Endometrium
COSM3909085	c.3208C>T	p.R1070C	Substitution - Missense	Stomach
COSM5411508	c.702C>T	p.T234T	Substitution - coding silent	Skin
COSM4433253	c.3085G>A	p.A1029T	Substitution - Missense	Oesophagus
COSM305500	c.2961_2962ins15	p.T987_P988insPASTT	Insertion - In frame	Large_intestine
COSM1578427	c.2963_2964ins15	p.T996_S997insTPAST	Insertion - In frame	Large_intestine
COSM4611878	c.1467_1468insA	p.T493fs*21	Insertion - Frameshift	Large_intestine
COSM3750192	c.2964G>T	p.P988P	Substitution - coding silent	Large_intestine
COSM198796	c.1468delA	p.K492fs*6	Deletion - Frameshift	Large_intestine
COSM4149565	c.2022G>A	p.R674R	Substitution - coding silent	Ovary
COSM4713971	c.1106C>T	p.A369V	Substitution - Missense	Large_intestine
COSM1111299	c.1977C>T	p.F659F	Substitution - coding silent	Endometrium
COSM4589050	c.1107G>A	p.A369A	Substitution - coding silent	Bone
COSM5662080	c.3070C>A	p.H1024N	Substitution - Missense	Soft_tissue
COSM5718394	c.442G>C	p.D148H	Substitution - Missense	Skin
COSM198796	c.1468delA	p.K492fs*6	Deletion - Frameshift	Large_intestine
COSM3659713	c.947C>T	p.P316L	Substitution - Missense	Skin
COSM305500	c.2961_2962ins15	p.T987_P988insPASTT	Insertion - In frame	Large_intestine
COSM3750192	c.2964G>T	p.P988P	Substitution - coding silent	Large_intestine
COSM1636290	c.952+10G>T	p.?	Unknown	Liver
COSM3909079	c.2025T>C	p.D675D	Substitution - coding silent	Stomach
COSM297068	c.2961C>A	p.T987T	Substitution - coding silent	Large_intestine
COSM305500	c.2961_2962ins15	p.T987_P988insPASTT	Insertion - In frame	Upper_aerodigestive_tract
COSM5757438	c.1831G>A	p.D611N	Substitution - Missense	Large_intestine
COSM4139020	c.2946G>C	p.T982T	Substitution - coding silent	Thyroid
COSM3723034	c.2976C>A	p.T992T	Substitution - coding silent	Large_intestine
COSM305500	c.2961_2962ins15	p.T987_P988insPASTT	Insertion - In frame	Large_intestine
COSM3659720	c.2399C>T	p.S800F	Substitution - Missense	Skin
COSM3750192	c.2964G>T	p.P988P	Substitution - coding silent	Large_intestine
COSM3723035	c.2955T>C	p.S985S	Substitution - coding silent	Upper_aerodigestive_tract
COSM1220358	c.1559C>T	p.T520M	Substitution - Missense	Large_intestine
COSM1463737	c.2949A>T	p.P983P	Substitution - coding silent	Thyroid
COSM121541	c.2736A>G	p.P912P	Substitution - coding silent	Upper_aerodigestive_tract
COSM3716320	c.2453G>T	p.G818V	Substitution - Missense	Upper_aerodigestive_tract
COSM297068	c.2961C>A	p.T987T	Substitution - coding silent	Lung
COSM4007303	c.309C>T	p.D103D	Substitution - coding silent	Urinary_tract
COSM3747771	c.2990G>C	p.S997T	Substitution - Missense	Liver
COSM314120	c.2683delA	p.R896fs*64	Deletion - Frameshift	Soft_tissue
COSM305500	c.2961_2962ins15	p.T987_P988insPASTT	Insertion - In frame	Large_intestine
COSM1111300	c.1981G>A	p.A661T	Substitution - Missense	Endometrium
COSM3659712	c.397G>A	p.D133N	Substitution - Missense	Skin
COSM2732633	c.2851delA	p.K953fs*7	Deletion - Frameshift	Large_intestine
COSM5352128	c.2242G>A	p.G748S	Substitution - Missense	Pancreas
COSM1463723	c.185T>C	p.L62S	Substitution - Missense	Large_intestine
COSM1625262	c.170A>G	p.H57R	Substitution - Missense	Liver
COSM4657053	c.233A>T	p.D78V	Substitution - Missense	Large_intestine
COSM3723034	c.2976C>A	p.T992T	Substitution - coding silent	Thyroid
COSM5826522	c.2955_2956ins15	p.T996_S997insTPAST	Insertion - In frame	Large_intestine
COSM3909078	c.2017G>A	p.V673M	Substitution - Missense	Stomach
COSM297068	c.2961C>A	p.T987T	Substitution - coding silent	Lung
COSM4771861	c.3273C>T	p.N1091N	Substitution - coding silent	Stomach
COSM1220354	c.386T>C	p.V129A	Substitution - Missense	Large_intestine
COSM305500	c.2961_2962ins15	p.T987_P988insPASTT	Insertion - In frame	Large_intestine
COSM297068	c.2961C>A	p.T987T	Substitution - coding silent	Liver
COSM1220355	c.1477A>G	p.T493A	Substitution - Missense	Large_intestine
COSM305500	c.2961_2962ins15	p.T987_P988insPASTT	Insertion - In frame	Large_intestine
COSM3750192	c.2964G>T	p.P988P	Substitution - coding silent	Lung
COSM198796	c.1468delA	p.K492fs*6	Deletion - Frameshift	Large_intestine
COSM1578427	c.2963_2964ins15	p.T996_S997insTPAST	Insertion - In frame	Lung
COSM1220355	c.1477A>G	p.T493A	Substitution - Missense	Large_intestine
COSM198796	c.1468delA	p.K492fs*6	Deletion - Frameshift	Large_intestine
COSM3723035	c.2955T>C	p.S985S	Substitution - coding silent	Lung
COSM3685903	c.40T>A	p.Y14N	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1569866	c.2562C>T	p.V854V	Substitution - coding silent	Large_intestine
COSM198796	c.1468delA	p.K492fs*6	Deletion - Frameshift	Prostate
COSM198796	c.1468delA	p.K492fs*6	Deletion - Frameshift	Biliary_tract
COSM198796	c.1468delA	p.K492fs*6	Deletion - Frameshift	Large_intestine
COSM1625262	c.170A>G	p.H57R	Substitution - Missense	Liver
COSM198796	c.1468delA	p.K492fs*6	Deletion - Frameshift	Large_intestine
COSM305500	c.2961_2962ins15	p.T987_P988insPASTT	Insertion - In frame	Large_intestine
COSM3849111	c.73G>A	p.A25T	Substitution - Missense	Breast
COSM305500	c.2961_2962ins15	p.T987_P988insPASTT	Insertion - In frame	Large_intestine
COSM3750192	c.2964G>T	p.P988P	Substitution - coding silent	Lung
COSM4609839	c.3283delC	p.L1095fs*>2	Deletion - Frameshift	Adrenal_gland
COSM4885372	c.2209G>T	p.G737C	Substitution - Missense	Upper_aerodigestive_tract
COSM297068	c.2961C>A	p.T987T	Substitution - coding silent	Upper_aerodigestive_tract
COSM5826522	c.2955_2956ins15	p.T996_S997insTPAST	Insertion - In frame	Large_intestine
COSM5718394	c.442G>C	p.D148H	Substitution - Missense	Skin
COSM3747772	c.2992A>C	p.T998P	Substitution - Missense	Thyroid
COSM305500	c.2961_2962ins15	p.T987_P988insPASTT	Insertion - In frame	Upper_aerodigestive_tract
COSM1463724	c.548G>A	p.S183N	Substitution - Missense	Large_intestine
COSM4468397	c.1541C>T	p.P514L	Substitution - Missense	Skin
COSM198796	c.1468delA	p.K492fs*6	Deletion - Frameshift	Prostate
COSM3723035	c.2955T>C	p.S985S	Substitution - coding silent	Lung
COSM305500	c.2961_2962ins15	p.T987_P988insPASTT	Insertion - In frame	Large_intestine
COSM3723034	c.2976C>A	p.T992T	Substitution - coding silent	Biliary_tract
COSM297068	c.2961C>A	p.T987T	Substitution - coding silent	Thyroid
COSM1111295	c.848G>A	p.R283H	Substitution - Missense	Large_intestine
COSM305500	c.2961_2962ins15	p.T987_P988insPASTT	Insertion - In frame	Large_intestine
COSM753851	c.1084C>G	p.Q362E	Substitution - Missense	Lung
COSM3723035	c.2955T>C	p.S985S	Substitution - coding silent	Thyroid
COSM297068	c.2961C>A	p.T987T	Substitution - coding silent	Kidney
COSM297068	c.2961C>A	p.T987T	Substitution - coding silent	Thyroid
COSM305500	c.2961_2962ins15	p.T987_P988insPASTT	Insertion - In frame	Large_intestine
COSM2732578	c.234C>T	p.D78D	Substitution - coding silent	Large_intestine
COSM1111304	c.2614G>A	p.D872N	Substitution - Missense	Endometrium
COSM5352128	c.2242G>A	p.G748S	Substitution - Missense	Kidney
COSM314120	c.2683delA	p.R896fs*64	Deletion - Frameshift	Lung
COSM5752973	c.2256_2257ins13	p.G758fs*19	Insertion - Frameshift	Pancreas
COSM1187770	c.2986A>T	p.T996S	Substitution - Missense	Lung
COSM5938235	c.836C>A	p.S279Y	Substitution - Missense	Skin
COSM5826522	c.2955_2956ins15	p.T996_S997insTPAST	Insertion - In frame	Large_intestine
COSM1463737	c.2949A>T	p.P983P	Substitution - coding silent	Thyroid
COSM1220352	c.2099C>T	p.P700L	Substitution - Missense	Stomach
COSM198796	c.1468delA	p.K492fs*6	Deletion - Frameshift	Stomach
COSM1220352	c.2099C>T	p.P700L	Substitution - Missense	Large_intestine
COSM3849112	c.3240G>C	p.Q1080H	Substitution - Missense	Breast
COSM3927263	c.1176C>T	p.P392P	Substitution - coding silent	Skin
COSM3685904	c.1239+8T>A	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM5450938	c.2723-3C>T	p.?	Unknown	Large_intestine
COSM3750192	c.2964G>T	p.P988P	Substitution - coding silent	Lung
COSM5701170	c.2962_2963ins15	p.P988_A989insCLHHT	Insertion - In frame	Pancreas
COSM1701348	c.1616C>T	p.S539L	Substitution - Missense	Skin
COSM3723034	c.2976C>A	p.T992T	Substitution - coding silent	Thyroid
COSM198796	c.1468delA	p.K492fs*6	Deletion - Frameshift	Large_intestine
COSM3659715	c.1718G>A	p.S573N	Substitution - Missense	Skin
COSM305500	c.2961_2962ins15	p.T987_P988insPASTT	Insertion - In frame	Upper_aerodigestive_tract
COSM305500	c.2961_2962ins15	p.T987_P988insPASTT	Insertion - In frame	Large_intestine
COSM3750192	c.2964G>T	p.P988P	Substitution - coding silent	Large_intestine
COSM198796	c.1468delA	p.K492fs*6	Deletion - Frameshift	Prostate
COSM3982985	c.1122G>A	p.G374G	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM2732635	c.3242G>T	p.R1081M	Substitution - Missense	Large_intestine
COSM3716319	c.1969G>T	p.G657C	Substitution - Missense	Upper_aerodigestive_tract
COSM5573336	c.2833-1G>T	p.?	Unknown	Prostate
COSM3750192	c.2964G>T	p.P988P	Substitution - coding silent	Large_intestine
COSM3659711	c.388C>T	p.P130S	Substitution - Missense	Skin
COSM3909081	c.2402T>C	p.M801T	Substitution - Missense	Stomach
COSM3909082	c.2687G>T	p.R896M	Substitution - Missense	Stomach
COSM3750192	c.2964G>T	p.P988P	Substitution - coding silent	Large_intestine
COSM5819388	c.2128A>T	p.K710*	Substitution - Nonsense	Liver
COSM1463737	c.2949A>T	p.P983P	Substitution - coding silent	Liver
COSM4888808	c.818C>A	p.P273Q	Substitution - Missense	Upper_aerodigestive_tract
COSM3909075	c.649T>C	p.W217R	Substitution - Missense	Stomach
COSM198796	c.1468delA	p.K492fs*6	Deletion - Frameshift	Large_intestine
COSM305500	c.2961_2962ins15	p.T987_P988insPASTT	Insertion - In frame	Large_intestine
COSM4971765	c.534G>A	p.V178V	Substitution - coding silent	Central_nervous_system
COSM1701347	c.1000G>A	p.G334R	Substitution - Missense	Skin
COSM295171	c.720C>T	p.C240C	Substitution - coding silent	Large_intestine
COSM1220356	c.1498C>A	p.P500T	Substitution - Missense	Stomach
COSM1262044	c.2488G>A	p.A830T	Substitution - Missense	Oesophagus
COSM5007144	c.442G>A	p.D148N	Substitution - Missense	Large_intestine
COSM334955	c.2700C>T	p.D900D	Substitution - coding silent	Lung
COSM1721319	c.1193G>A	p.G398E	Substitution - Missense	Skin
COSM305500	c.2961_2962ins15	p.T987_P988insPASTT	Insertion - In frame	Large_intestine
COSM753854	c.304G>A	p.E102K	Substitution - Missense	Lung
COSM5826522	c.2955_2956ins15	p.T996_S997insTPAST	Insertion - In frame	Large_intestine
COSM198796	c.1468delA	p.K492fs*6	Deletion - Frameshift	Large_intestine
COSM3750192	c.2964G>T	p.P988P	Substitution - coding silent	Thyroid
COSM5701170	c.2962_2963ins15	p.P988_A989insCLHHT	Insertion - In frame	Soft_tissue
COSM4487523	c.319C>T	p.R107C	Substitution - Missense	Skin
COSM1220353	c.854G>A	p.R285Q	Substitution - Missense	Large_intestine
COSM4589051	c.2003A>G	p.D668G	Substitution - Missense	Bone
COSM1220359	c.1196C>A	p.A399D	Substitution - Missense	Large_intestine
COSM753850	c.2730C>T	p.V910V	Substitution - coding silent	Lung
COSM3909077	c.1875G>A	p.S625S	Substitution - coding silent	Stomach
COSM3750192	c.2964G>T	p.P988P	Substitution - coding silent	Large_intestine
COSM4417122	c.789+6C>T	p.?	Unknown	Oesophagus
COSM5826522	c.2955_2956ins15	p.T996_S997insTPAST	Insertion - In frame	Large_intestine
COSM4759064	c.1186G>A	p.V396I	Substitution - Missense	Stomach
COSM255626	c.1261G>C	p.E421Q	Substitution - Missense	Central_nervous_system
COSM1463727	c.996C>T	p.F332F	Substitution - coding silent	Large_intestine
COSM1111307	c.2800C>T	p.L934L	Substitution - coding silent	Endometrium
COSM305500	c.2961_2962ins15	p.T987_P988insPASTT	Insertion - In frame	Large_intestine
COSM422311	c.615C>T	p.F205F	Substitution - coding silent	Urinary_tract
COSM3750192	c.2964G>T	p.P988P	Substitution - coding silent	Lung
COSM3723035	c.2955T>C	p.S985S	Substitution - coding silent	Prostate
COSM305500	c.2961_2962ins15	p.T987_P988insPASTT	Insertion - In frame	Large_intestine
COSM1111308	c.3089G>A	p.G1030D	Substitution - Missense	Endometrium
COSM4611878	c.1467_1468insA	p.T493fs*21	Insertion - Frameshift	Large_intestine
COSM1173529	c.209A>G	p.K70R	Substitution - Missense	Oesophagus
COSM3723034	c.2976C>A	p.T992T	Substitution - coding silent	Upper_aerodigestive_tract
COSM305500	c.2961_2962ins15	p.T987_P988insPASTT	Insertion - In frame	Large_intestine
COSM3659714	c.1092C>T	p.P364P	Substitution - coding silent	Skin
COSM1463733	c.1883C>T	p.A628V	Substitution - Missense	Large_intestine
COSM1463737	c.2949A>T	p.P983P	Substitution - coding silent	Kidney

> Text Mining based Variations

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PMID	Variation	Cancer	Evidence
27744626	Mutation	Colorectal Carcinoma; Gastric Carcinoma	For this, we analyzed 124 colorectal cancers (CRCs) and 79 gastric (GCs) cancers for the mutations and their intratumoral heterogeneity (ITH). Twenty-two of 79 CRCs (27.8 %) and 7 of 34 GCs (20.6 %) harboring MSI-H exhibited frameshift mutations. Our data reveal that TSG gene PHF2 harbors mutational ITH as well as the frameshift mutations in CRC and GC with MSI-H. Based on this, it is suggested that frameshift mutations of PHF2 may play a role in tumorigenesis through its TSG inactivation in CRC and GC.

Summary
Symbol	PHF2
Name	PHD finger protein 2
Aliases	KIAA0662; JHDM1E; CENP-35; jumonji C domain-containing histone demethylase 1E; centromere protein 35; GRC5; ......
Location	9q22.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

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Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
O75151	479	T	Phosphothreonine	-	No	None detected
O75151	539	S	Phosphoserine	-	No	None detected
O75151	655	S	Phosphoserine	-	No	None detected
O75151	681	S	Phosphoserine	-	No	None detected
O75151	705	S	Phosphoserine	-	No	None detected
O75151	720	K	N6-acetyllysine	-	No	None detected
O75151	728	Y	Phosphotyrosine	-	No	None detected
O75151	730	S	Phosphoserine	-	No	None detected
O75151	733	S	Phosphoserine	-	No	None detected
O75151	734	S	Phosphoserine	-	No	None detected
O75151	738	S	Phosphoserine	-	No	None detected
O75151	879	S	Phosphoserine	-	No	None detected
O75151	882	S	Phosphoserine	-	No	None detected
O75151	899	S	Phosphoserine	-	No	None detected
O75151	1056	S	Phosphoserine	PKA	No	None detected

Summary
Symbol	PHF2
Name	PHD finger protein 2
Aliases	KIAA0662; JHDM1E; CENP-35; jumonji C domain-containing histone demethylase 1E; centromere protein 35; GRC5; ......
Location	9q22.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

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Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	6.159	5.757	-0.356	0.015	NS
BRCA	Breast invasive carcinoma	112	1100	6.301	6.089	-0.254	3.07e-07	NS
CESC	Cervical and endocervical cancers	3	306	6.468	5.826	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	5.71	5.56	-0.239	0.00406	NS
ESCA	Esophageal carcinoma	11	185	5.982	5.816	-0.312	0.0905	NS
GBM	Glioblastoma multiforme	5	166	5.876	6.041	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	5.624	5.547	-0.103	0.354	NS
KIRC	Kidney renal clear cell carcinoma	72	534	5.69	5.579	-0.141	0.0119	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	5.681	5.336	-0.411	6.64e-05	NS
LAML	Acute Myeloid Leukemia	0	173	NA	5.884	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	6.761	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	4.333	4.104	-0.282	0.00972	NS
LUAD	Lung adenocarcinoma	59	517	6.365	5.628	-0.669	2.59e-21	Under
LUSC	Lung squamous cell carcinoma	51	501	6.246	5.774	-0.46	9.91e-08	NS
OV	Ovarian serous cystadenocarcinoma	0	307	NA	5.602	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	5.909	5.822	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	5.361	6.491	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	6.394	6.257	-0.107	0.217	NS
READ	Rectum adenocarcinoma	10	167	5.941	5.655	-0.314	0.093	NS
SARC	Sarcoma	2	263	5.236	6.184	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	5.386	5.447	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	5.965	5.649	-0.311	0.00155	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	5.687	NA	NA	NA
THCA	Thyroid carcinoma	59	509	6.302	6.194	-0.103	0.0863	NS
THYM	Thymoma	2	120	6.578	6.062	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	6.552	5.7	-0.884	5.62e-15	Under

> Cancer Cell Line Encyclopedia (CCLE)

[ TOP ]

Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	9.7
Autonomic ganglia	CHP212	8.6
Autonomic ganglia	IMR32	9.2
Autonomic ganglia	KELLY	7.1
Autonomic ganglia	KPNRTBM1	9.8
Autonomic ganglia	KPNSI9S	7.5
Autonomic ganglia	KPNYN	9.1
Autonomic ganglia	MHHNB11	9.8
Autonomic ganglia	NB1	9
Autonomic ganglia	NH6	8.9
Autonomic ganglia	SHSY5Y	8.8
Autonomic ganglia	SIMA	9.3
Autonomic ganglia	SKNAS	8.3
Autonomic ganglia	SKNBE2	8.5
Autonomic ganglia	SKNDZ	8.3
Autonomic ganglia	SKNFI	8.5
Autonomic ganglia	SKNSH	8
Biliary tract	HUCCT1	7.6
Biliary tract	HUH28	7.9
Biliary tract	SNU1079	7.6
Biliary tract	SNU1196	9.2
Biliary tract	SNU245	8.9
Biliary tract	SNU308	9
Biliary tract	SNU478	7.6
Bone	143B	7.5
Bone	A673	8.6
Bone	CADOES1	9.3
Bone	CAL78	8.7
Bone	G292CLONEA141B1	7.9
Bone	HOS	8.1
Bone	HS706T	8.1
Bone	HS737T	7.8
Bone	HS819T	7.8
Bone	HS821T	8.3
Bone	HS822T	7.9
Bone	HS863T	8.6
Bone	HS870T	7.6
Bone	HS888T	8.2
Bone	MG63	8.1
Bone	MHHES1	9.9
Bone	OUMS27	7.9
Bone	RDES	8.7
Bone	SJSA1	7.9
Bone	SKES1	8.7
Bone	SKNMC	8.6
Bone	SW1353	8
Bone	T173	7.6
Bone	TC71	8
Bone	U2OS	8.3
Breast	AU565	8.2
Breast	BT20	8.7
Breast	BT474	8
Breast	BT483	9.4
Breast	BT549	8.2
Breast	CAL120	8.2
Breast	CAL148	9.6
Breast	CAL51	7.4
Breast	CAL851	7.3
Breast	CAMA1	8.4
Breast	DU4475	8.6
Breast	EFM192A	8.6
Breast	EFM19	8.8
Breast	EVSAT	7.8
Breast	HCC1143	7.6
Breast	HCC1187	9
Breast	HCC1395	8.1
Breast	HCC1419	8.7
Breast	HCC1428	8.8
Breast	HCC1500	9.3
Breast	HCC1569	7.1
Breast	HCC1599	9.9
Breast	HCC1806	8.6
Breast	HCC1937	8.3
Breast	HCC1954	8.3
Breast	HCC202	8.4
Breast	HCC2157	7.9
Breast	HCC2218	8
Breast	HCC38	8.7
Breast	HCC70	7.9
Breast	HDQP1	8.5
Breast	HMC18	8.5
Breast	HS274T	8.3
Breast	HS281T	8
Breast	HS343T	8.2
Breast	HS578T	7.7
Breast	HS606T	7.9
Breast	HS739T	7.6
Breast	HS742T	8
Breast	JIMT1	9.5
Breast	KPL1	9.2
Breast	MCF7	8.4
Breast	MDAMB134VI	9.1
Breast	MDAMB157	9.1
Breast	MDAMB175VII	8.4
Breast	MDAMB231	7.9
Breast	MDAMB361	8.2
Breast	MDAMB415	7.8
Breast	MDAMB436	9.3
Breast	MDAMB453	8.3
Breast	MDAMB468	7.9
Breast	SKBR3	8.5
Breast	T47D	7.8
Breast	UACC812	8.9
Breast	UACC893	8.4
Breast	YMB1	7.9
Breast	ZR751	7.7
Breast	ZR7530	8.5
Central nervous system	1321N1	8.2
Central nervous system	42MGBA	7.8
Central nervous system	8MGBA	6.4
Central nervous system	A172	8
Central nervous system	AM38	7.8
Central nervous system	BECKER	8.2
Central nervous system	CAS1	8
Central nervous system	CCFSTTG1	8.5
Central nervous system	D283MED	8.2
Central nervous system	D341MED	8.6
Central nervous system	DAOY	8.4
Central nervous system	DBTRG05MG	8.4
Central nervous system	DKMG	8.9
Central nervous system	GAMG	7.9
Central nervous system	GB1	9.5
Central nervous system	GI1	8
Central nervous system	GMS10	8.5
Central nervous system	GOS3	8.3
Central nervous system	H4	7.7
Central nervous system	HS683	8
Central nervous system	KALS1	8.1
Central nervous system	KG1C	8.1
Central nervous system	KNS42	8.5
Central nervous system	KNS60	7.8
Central nervous system	KNS81	7.6
Central nervous system	KS1	7.8
Central nervous system	LN18	7.7
Central nervous system	LN229	8.3
Central nervous system	M059K	7.7
Central nervous system	MOGGCCM	8.2
Central nervous system	MOGGUVW	7.9
Central nervous system	NMCG1	8.1
Central nervous system	ONS76	8.1
Central nervous system	SF126	7.9
Central nervous system	SF295	7.8
Central nervous system	SNB19	8.4
Central nervous system	SNU1105	8.4
Central nervous system	SNU201	8.7
Central nervous system	SNU466	8.7
Central nervous system	SNU489	8.9
Central nervous system	SNU626	9
Central nervous system	SNU738	8.3
Central nervous system	SW1088	8.1
Central nervous system	SW1783	8.1
Central nervous system	T98G	7.9
Central nervous system	TM31	9.3
Central nervous system	U118MG	8.1
Central nervous system	U138MG	8.4
Central nervous system	U251MG	9
Central nervous system	U87MG	7.5
Central nervous system	YH13	8.1
Central nervous system	YKG1	8.6
Endometrium	AN3CA	8.6
Endometrium	COLO684	9.2
Endometrium	EFE184	5.9
Endometrium	EN	6.8
Endometrium	ESS1	8.1
Endometrium	HEC108	7.4
Endometrium	HEC151	7.3
Endometrium	HEC1A	8.3
Endometrium	HEC1B	8
Endometrium	HEC251	7.7
Endometrium	HEC265	7.6
Endometrium	HEC50B	7.4
Endometrium	HEC59	6.8
Endometrium	HEC6	6.4
Endometrium	ISHIKAWAHERAKLIO02ER	7.3
Endometrium	JHUEM1	7.7
Endometrium	JHUEM2	8.2
Endometrium	JHUEM3	8.7
Endometrium	KLE	6.8
Endometrium	MFE280	8.2
Endometrium	MFE296	8.5
Endometrium	MFE319	6.8
Endometrium	RL952	7.3
Endometrium	SNGM	8.5
Endometrium	SNU1077	8.1
Endometrium	SNU685	8.5
Endometrium	TEN	7.3
Haematopoietic and lymphoid	697	9.5
Haematopoietic and lymphoid	A3KAW	7.7
Haematopoietic and lymphoid	A4FUK	7.3
Haematopoietic and lymphoid	ALLSIL	9.7
Haematopoietic and lymphoid	AML193	8.8
Haematopoietic and lymphoid	AMO1	8.2
Haematopoietic and lymphoid	BCP1	8.1
Haematopoietic and lymphoid	BDCM	7.9
Haematopoietic and lymphoid	BL41	8.5
Haematopoietic and lymphoid	BL70	8.2
Haematopoietic and lymphoid	BV173	9
Haematopoietic and lymphoid	CA46	7.7
Haematopoietic and lymphoid	CI1	8
Haematopoietic and lymphoid	CMK115	7.4
Haematopoietic and lymphoid	CMK86	8.4
Haematopoietic and lymphoid	CMK	7.4
Haematopoietic and lymphoid	CMLT1	9.6
Haematopoietic and lymphoid	COLO775	6.4
Haematopoietic and lymphoid	DAUDI	7.4
Haematopoietic and lymphoid	DB	7.4
Haematopoietic and lymphoid	DEL	8.8
Haematopoietic and lymphoid	DND41	9.8
Haematopoietic and lymphoid	DOHH2	9.4
Haematopoietic and lymphoid	EB1	8
Haematopoietic and lymphoid	EB2	8
Haematopoietic and lymphoid	EHEB	8.2
Haematopoietic and lymphoid	EJM	8.1
Haematopoietic and lymphoid	EM2	7.9
Haematopoietic and lymphoid	EOL1	8.4
Haematopoietic and lymphoid	F36P	8.4
Haematopoietic and lymphoid	GA10	8.1
Haematopoietic and lymphoid	GDM1	8.3
Haematopoietic and lymphoid	GRANTA519	8.8
Haematopoietic and lymphoid	HDLM2	9.3
Haematopoietic and lymphoid	HDMYZ	8.7
Haematopoietic and lymphoid	HEL9217	7.4
Haematopoietic and lymphoid	HEL	8.1
Haematopoietic and lymphoid	HH	7.2
Haematopoietic and lymphoid	HL60	8.6
Haematopoietic and lymphoid	HPBALL	10.2
Haematopoietic and lymphoid	HS604T	7.8
Haematopoietic and lymphoid	HS611T	7.5
Haematopoietic and lymphoid	HS616T	7.8
Haematopoietic and lymphoid	HS751T	8.3
Haematopoietic and lymphoid	HT	8.2
Haematopoietic and lymphoid	HTK	8
Haematopoietic and lymphoid	HUNS1	7.9
Haematopoietic and lymphoid	HUT102	8.8
Haematopoietic and lymphoid	HUT78	8.1
Haematopoietic and lymphoid	JEKO1	10.2
Haematopoietic and lymphoid	JK1	8.9
Haematopoietic and lymphoid	JM1	8.3
Haematopoietic and lymphoid	JURKAT	9.2
Haematopoietic and lymphoid	JURLMK1	8.4
Haematopoietic and lymphoid	JVM2	8.4
Haematopoietic and lymphoid	JVM3	8.3
Haematopoietic and lymphoid	K562	8
Haematopoietic and lymphoid	KARPAS299	8.9
Haematopoietic and lymphoid	KARPAS422	8.9
Haematopoietic and lymphoid	KARPAS620	8
Haematopoietic and lymphoid	KASUMI1	8.8
Haematopoietic and lymphoid	KASUMI2	9.1
Haematopoietic and lymphoid	KASUMI6	8.4
Haematopoietic and lymphoid	KCL22	8.2
Haematopoietic and lymphoid	KE37	9.5
Haematopoietic and lymphoid	KE97	7.8
Haematopoietic and lymphoid	KG1	7.9
Haematopoietic and lymphoid	KHM1B	7.2
Haematopoietic and lymphoid	KIJK	8.4
Haematopoietic and lymphoid	KMH2	9.2
Haematopoietic and lymphoid	KMM1	7.8
Haematopoietic and lymphoid	KMS11	8.2
Haematopoietic and lymphoid	KMS12BM	8.2
Haematopoietic and lymphoid	KMS18	8.5
Haematopoietic and lymphoid	KMS20	8.2
Haematopoietic and lymphoid	KMS21BM	6.8
Haematopoietic and lymphoid	KMS26	7.9
Haematopoietic and lymphoid	KMS27	6.9
Haematopoietic and lymphoid	KMS28BM	8.2
Haematopoietic and lymphoid	KMS34	4.5
Haematopoietic and lymphoid	KO52	7.5
Haematopoietic and lymphoid	KOPN8	9.5
Haematopoietic and lymphoid	KU812	8.4
Haematopoietic and lymphoid	KYO1	7.8
Haematopoietic and lymphoid	L1236	7.8
Haematopoietic and lymphoid	L363	9.2
Haematopoietic and lymphoid	L428	8.4
Haematopoietic and lymphoid	L540	8.6
Haematopoietic and lymphoid	LAMA84	8.5
Haematopoietic and lymphoid	LOUCY	8.7
Haematopoietic and lymphoid	LP1	8.9
Haematopoietic and lymphoid	M07E	8.9
Haematopoietic and lymphoid	MC116	7.8
Haematopoietic and lymphoid	ME1	8
Haematopoietic and lymphoid	MEC1	9.3
Haematopoietic and lymphoid	MEC2	8.6
Haematopoietic and lymphoid	MEG01	7.7
Haematopoietic and lymphoid	MHHCALL2	9.2
Haematopoietic and lymphoid	MHHCALL3	10.4
Haematopoietic and lymphoid	MHHCALL4	9.3
Haematopoietic and lymphoid	MINO	8.3
Haematopoietic and lymphoid	MJ	8.2
Haematopoietic and lymphoid	MM1S	7.9
Haematopoietic and lymphoid	MOLM13	8.1
Haematopoietic and lymphoid	MOLM16	8.2
Haematopoietic and lymphoid	MOLM6	8.7
Haematopoietic and lymphoid	MOLP2	8
Haematopoietic and lymphoid	MOLP8	8.8
Haematopoietic and lymphoid	MOLT13	9.2
Haematopoietic and lymphoid	MOLT16	9.2
Haematopoietic and lymphoid	MOLT4	8.4
Haematopoietic and lymphoid	MONOMAC1	8.7
Haematopoietic and lymphoid	MONOMAC6	9.4
Haematopoietic and lymphoid	MOTN1	9
Haematopoietic and lymphoid	MUTZ5	9.8
Haematopoietic and lymphoid	MV411	8.7
Haematopoietic and lymphoid	NALM19	9.7
Haematopoietic and lymphoid	NALM1	9.8
Haematopoietic and lymphoid	NALM6	8.9
Haematopoietic and lymphoid	NAMALWA	8.8
Haematopoietic and lymphoid	NB4	8.2
Haematopoietic and lymphoid	NCIH929	6.9
Haematopoietic and lymphoid	NCO2	7.3
Haematopoietic and lymphoid	NOMO1	8.5
Haematopoietic and lymphoid	NUDHL1	8.9
Haematopoietic and lymphoid	NUDUL1	8.8
Haematopoietic and lymphoid	OCIAML2	9.4
Haematopoietic and lymphoid	OCIAML3	9
Haematopoietic and lymphoid	OCIAML5	9.1
Haematopoietic and lymphoid	OCILY10	8.2
Haematopoietic and lymphoid	OCILY19	9.8
Haematopoietic and lymphoid	OCILY3	8.2
Haematopoietic and lymphoid	OCIM1	8
Haematopoietic and lymphoid	OPM2	8.5
Haematopoietic and lymphoid	P12ICHIKAWA	8.7
Haematopoietic and lymphoid	P31FUJ	8.3
Haematopoietic and lymphoid	P3HR1	7
Haematopoietic and lymphoid	PCM6	7.4
Haematopoietic and lymphoid	PEER	7.6
Haematopoietic and lymphoid	PF382	9.9
Haematopoietic and lymphoid	PFEIFFER	8.3
Haematopoietic and lymphoid	PL21	9
Haematopoietic and lymphoid	RAJI	7.7
Haematopoietic and lymphoid	RCHACV	9.1
Haematopoietic and lymphoid	REC1	9.1
Haematopoietic and lymphoid	REH	8.6
Haematopoietic and lymphoid	RI1	9.6
Haematopoietic and lymphoid	RL	6.5
Haematopoietic and lymphoid	RPMI8226	6.2
Haematopoietic and lymphoid	RPMI8402	9.6
Haematopoietic and lymphoid	RS411	8.6
Haematopoietic and lymphoid	SEM	8.9
Haematopoietic and lymphoid	SET2	8.5
Haematopoietic and lymphoid	SIGM5	8.3
Haematopoietic and lymphoid	SKM1	7.9
Haematopoietic and lymphoid	SKMM2	7.6
Haematopoietic and lymphoid	SR786	9.5
Haematopoietic and lymphoid	ST486	8.4
Haematopoietic and lymphoid	SUDHL10	7.6
Haematopoietic and lymphoid	SUDHL1	8.7
Haematopoietic and lymphoid	SUDHL4	8.4
Haematopoietic and lymphoid	SUDHL5	8.8
Haematopoietic and lymphoid	SUDHL6	7.5
Haematopoietic and lymphoid	SUDHL8	8.4
Haematopoietic and lymphoid	SUPB15	8.7
Haematopoietic and lymphoid	SUPHD1	8.6
Haematopoietic and lymphoid	SUPM2	8.5
Haematopoietic and lymphoid	SUPT11	9.5
Haematopoietic and lymphoid	SUPT1	8.5
Haematopoietic and lymphoid	TALL1	10.2
Haematopoietic and lymphoid	TF1	8
Haematopoietic and lymphoid	THP1	8.3
Haematopoietic and lymphoid	TO175T	8.2
Haematopoietic and lymphoid	TOLEDO	8.2
Haematopoietic and lymphoid	U266B1	5
Haematopoietic and lymphoid	U937	8
Haematopoietic and lymphoid	UT7	8.8
Haematopoietic and lymphoid	WSUDLCL2	8.3
Kidney	769P	7.8
Kidney	786O	8.3
Kidney	A498	8
Kidney	A704	7.2
Kidney	ACHN	7.3
Kidney	BFTC909	8.6
Kidney	CAKI1	7
Kidney	CAKI2	7.3
Kidney	CAL54	8.8
Kidney	KMRC1	7
Kidney	KMRC20	7.8
Kidney	KMRC2	6.8
Kidney	KMRC3	7.9
Kidney	OSRC2	7.6
Kidney	RCC10RGB	7.9
Kidney	SNU1272	8.3
Kidney	SNU349	7.8
Kidney	TUHR10TKB	8.7
Kidney	TUHR14TKB	8.1
Kidney	TUHR4TKB	7.7
Kidney	VMRCRCW	7.4
Kidney	VMRCRCZ	7.3
Large intestine	C2BBE1	7
Large intestine	CCK81	7.3
Large intestine	CL11	8.4
Large intestine	CL14	8.6
Large intestine	CL34	7.9
Large intestine	CL40	8.6
Large intestine	COLO205	8.1
Large intestine	COLO320	8.9
Large intestine	COLO678	9.6
Large intestine	CW2	7.5
Large intestine	DLD1	8.3
Large intestine	GP2D	8.4
Large intestine	HCC56	8.3
Large intestine	HCT116	7.8
Large intestine	HCT15	8.1
Large intestine	HS675T	7.9
Large intestine	HS698T	8.3
Large intestine	HT115	8.7
Large intestine	HT29	8.1
Large intestine	HT55	9.7
Large intestine	KM12	7.9
Large intestine	LOVO	7.7
Large intestine	LS1034	9.1
Large intestine	LS123	9.2
Large intestine	LS180	8
Large intestine	LS411N	8.5
Large intestine	LS513	9.5
Large intestine	MDST8	9.1
Large intestine	NCIH508	8.2
Large intestine	NCIH716	7.6
Large intestine	NCIH747	8.3
Large intestine	OUMS23	8
Large intestine	RCM1	7.8
Large intestine	RKO	8.1
Large intestine	SKCO1	8.2
Large intestine	SNU1040	8.6
Large intestine	SNU1197	8
Large intestine	SNU175	7.7
Large intestine	SNU283	8.9
Large intestine	SNU407	7.1
Large intestine	SNU503	8.8
Large intestine	SNU61	9.1
Large intestine	SNU81	9.3
Large intestine	SNUC1	8.3
Large intestine	SNUC2A	7.3
Large intestine	SNUC4	8.3
Large intestine	SNUC5	9.1
Large intestine	SW1116	7.2
Large intestine	SW1417	8.4
Large intestine	SW1463	8.2
Large intestine	SW403	8.3
Large intestine	SW480	7.5
Large intestine	SW48	8
Large intestine	SW620	8.2
Large intestine	SW837	8.7
Large intestine	SW948	8.9
Large intestine	T84	8
Liver	ALEXANDERCELLS	7.2
Liver	C3A	7.1
Liver	HEP3B217	8.8
Liver	HEPG2	7.9
Liver	HLE	6.7
Liver	HLF	6.9
Liver	HUH1	7.4
Liver	HUH6	7.5
Liver	HUH7	7.4
Liver	JHH1	7.5
Liver	JHH2	7.7
Liver	JHH4	6.8
Liver	JHH5	7.5
Liver	JHH6	9.1
Liver	JHH7	7.9
Liver	LI7	8.6
Liver	PLCPRF5	6.8
Liver	SKHEP1	7.9
Liver	SNU182	8.1
Liver	SNU387	8.6
Liver	SNU398	8.2
Liver	SNU423	8.1
Liver	SNU449	8.4
Liver	SNU475	7.8
Liver	SNU761	8.2
Liver	SNU878	6.5
Liver	SNU886	8.2
Lung	A549	7.4
Lung	ABC1	7.8
Lung	BEN	9.1
Lung	CAL12T	7.4
Lung	CALU1	8.1
Lung	CALU3	7.8
Lung	CALU6	7.8
Lung	CHAGOK1	8.6
Lung	COLO668	9.5
Lung	COLO699	8.3
Lung	CORL105	8.7
Lung	CORL23	7.5
Lung	CORL24	8.9
Lung	CORL279	7.8
Lung	CORL311	8.8
Lung	CORL47	10.1
Lung	CORL51	10.1
Lung	CORL88	10.7
Lung	CORL95	10.3
Lung	CPCN	8.5
Lung	DMS114	7.7
Lung	DMS153	8.4
Lung	DMS273	8.4
Lung	DMS454	9.2
Lung	DMS53	7.2
Lung	DMS79	8.2
Lung	DV90	7.9
Lung	EBC1	8.1
Lung	EPLC272H	7.9
Lung	HARA	8.3
Lung	HCC1171	8.7
Lung	HCC1195	8.7
Lung	HCC15	8
Lung	HCC2279	7.5
Lung	HCC2935	9.7
Lung	HCC33	9.4
Lung	HCC366	7.9
Lung	HCC4006	7.9
Lung	HCC44	7.7
Lung	HCC78	8.1
Lung	HCC827	7.8
Lung	HCC95	9.9
Lung	HLC1	9.6
Lung	HLFA	7.7
Lung	HS229T	7.8
Lung	HS618T	7.9
Lung	IALM	7.4
Lung	KNS62	7.2
Lung	LC1F	8.7
Lung	LC1SQSF	9.1
Lung	LCLC103H	8.4
Lung	LCLC97TM1	9.3
Lung	LK2	8.4
Lung	LOUNH91	8.2
Lung	LU65	7.8
Lung	LU99	7.7
Lung	LUDLU1	8.9
Lung	LXF289	9.1
Lung	MORCPR	9
Lung	NCIH1048	8.8
Lung	NCIH1092	10.1
Lung	NCIH1105	10.1
Lung	NCIH1155	9.1
Lung	NCIH1184	8.5
Lung	NCIH1299	8.2
Lung	NCIH1339	8.6
Lung	NCIH1341	7.9
Lung	NCIH1355	7.4
Lung	NCIH1373	8.2
Lung	NCIH1385	9.9
Lung	NCIH1395	5.7
Lung	NCIH1435	8.8
Lung	NCIH1436	9.8
Lung	NCIH1437	8.5
Lung	NCIH146	8.7
Lung	NCIH1563	7.7
Lung	NCIH1568	7.7
Lung	NCIH1573	7.3
Lung	NCIH1581	7.8
Lung	NCIH1618	9
Lung	NCIH1623	8.5
Lung	NCIH1648	7.8
Lung	NCIH1650	8.2
Lung	NCIH1651	7.9
Lung	NCIH1666	8.2
Lung	NCIH1693	4.4
Lung	NCIH1694	8
Lung	NCIH1703	7.9
Lung	NCIH1734	8
Lung	NCIH1755	8.2
Lung	NCIH1781	8.4
Lung	NCIH1792	7.3
Lung	NCIH1793	8.2
Lung	NCIH1836	8.5
Lung	NCIH1838	7.3
Lung	NCIH1869	7.9
Lung	NCIH1876	10.4
Lung	NCIH1915	7.1
Lung	NCIH1930	8.5
Lung	NCIH1944	8
Lung	NCIH1963	9.4
Lung	NCIH196	8.5
Lung	NCIH1975	7.7
Lung	NCIH2009	8.4
Lung	NCIH2023	7.7
Lung	NCIH2029	8.9
Lung	NCIH2030	7.2
Lung	NCIH2066	8.2
Lung	NCIH2081	10.1
Lung	NCIH2085	7.6
Lung	NCIH2087	7.5
Lung	NCIH209	8.8
Lung	NCIH2106	9.5
Lung	NCIH2110	8.4
Lung	NCIH211	7.9
Lung	NCIH2122	7.6
Lung	NCIH2126	8.3
Lung	NCIH2141	10.1
Lung	NCIH2170	8.2
Lung	NCIH2171	8.8
Lung	NCIH2172	8.4
Lung	NCIH2196	8.8
Lung	NCIH2227	7.8
Lung	NCIH2228	8
Lung	NCIH226	7.6
Lung	NCIH2286	8.6
Lung	NCIH2291	7.7
Lung	NCIH2342	8.4
Lung	NCIH2347	7.4
Lung	NCIH23	6.4
Lung	NCIH2405	7.8
Lung	NCIH2444	7.8
Lung	NCIH292	8.4
Lung	NCIH322	7.8
Lung	NCIH3255	8.5
Lung	NCIH358	8.2
Lung	NCIH441	7.4
Lung	NCIH446	7.6
Lung	NCIH460	8.1
Lung	NCIH510	8.5
Lung	NCIH520	8.1
Lung	NCIH522	8.8
Lung	NCIH524	8.7
Lung	NCIH526	8.1
Lung	NCIH596	8.2
Lung	NCIH647	7.4
Lung	NCIH650	8.2
Lung	NCIH661	7.8
Lung	NCIH69	9
Lung	NCIH727	8.4
Lung	NCIH810	8.9
Lung	NCIH82	7.5
Lung	NCIH838	7.2
Lung	NCIH841	8.1
Lung	NCIH854	8.7
Lung	NCIH889	9.6
Lung	PC14	8.1
Lung	RERFLCAD1	8.2
Lung	RERFLCAD2	7
Lung	RERFLCAI	7.6
Lung	RERFLCKJ	8.5
Lung	RERFLCMS	7.9
Lung	RERFLCSQ1	7.4
Lung	SBC5	8.2
Lung	SCLC21H	9.8
Lung	SHP77	8
Lung	SKLU1	7.1
Lung	SKMES1	7
Lung	SQ1	7.3
Lung	SW1271	8.4
Lung	SW1573	9.6
Lung	SW900	6.9
Lung	VMRCLCD	8
Lung	VMRCLCP	8.5
Oesophagus	COLO680N	9.2
Oesophagus	ECGI10	8.6
Oesophagus	KYSE140	8.7
Oesophagus	KYSE150	8.4
Oesophagus	KYSE180	8.5
Oesophagus	KYSE270	8
Oesophagus	KYSE30	9.7
Oesophagus	KYSE410	8.4
Oesophagus	KYSE450	8.3
Oesophagus	KYSE510	7.8
Oesophagus	KYSE520	8.4
Oesophagus	KYSE70	8.4
Oesophagus	OE19	8.7
Oesophagus	OE33	7.9
Oesophagus	TE10	8.5
Oesophagus	TE11	8.3
Oesophagus	TE14	10.6
Oesophagus	TE15	8.3
Oesophagus	TE1	7.7
Oesophagus	TE4	9.3
Oesophagus	TE5	9.1
Oesophagus	TE6	8.3
Oesophagus	TE8	9.2
Oesophagus	TE9	8.4
Oesophagus	TT	8.5
Ovary	59M	7.7
Ovary	A2780	8.1
Ovary	CAOV3	7.1
Ovary	CAOV4	7.1
Ovary	COLO704	8.4
Ovary	COV318	6.8
Ovary	COV362	8.4
Ovary	COV434	8.8
Ovary	COV504	8.1
Ovary	COV644	8
Ovary	EFO21	8
Ovary	EFO27	8.3
Ovary	ES2	7.1
Ovary	FUOV1	7.2
Ovary	HEYA8	7.5
Ovary	HS571T	7.5
Ovary	IGROV1	6.9
Ovary	JHOC5	7.9
Ovary	JHOM1	7.4
Ovary	JHOM2B	9.4
Ovary	JHOS2	8.1
Ovary	JHOS4	7.4
Ovary	KURAMOCHI	7.6
Ovary	MCAS	7.9
Ovary	NIHOVCAR3	7.9
Ovary	OAW28	8.9
Ovary	OAW42	8.4
Ovary	OC314	8
Ovary	OC316	7.8
Ovary	ONCODG1	8.6
Ovary	OV56	7.3
Ovary	OV7	8.7
Ovary	OV90	8.4
Ovary	OVCAR4	7
Ovary	OVCAR8	8.3
Ovary	OVISE	7.8
Ovary	OVK18	9.1
Ovary	OVKATE	8.5
Ovary	OVMANA	7.4
Ovary	OVSAHO	7
Ovary	OVTOKO	6.4
Ovary	RMGI	7.9
Ovary	RMUGS	8.3
Ovary	SKOV3	8.5
Ovary	SNU119	9
Ovary	SNU840	7.8
Ovary	SNU8	6.8
Ovary	TOV112D	8.9
Ovary	TOV21G	7.6
Ovary	TYKNU	7.2
Pancreas	ASPC1	7.4
Pancreas	BXPC3	8.2
Pancreas	CAPAN1	8.7
Pancreas	CAPAN2	7.6
Pancreas	CFPAC1	6.8
Pancreas	DANG	9.3
Pancreas	HPAC	9.2
Pancreas	HPAFII	7
Pancreas	HS766T	8.3
Pancreas	HUPT3	7.7
Pancreas	HUPT4	8.8
Pancreas	KCIMOH1	8.4
Pancreas	KLM1	9.3
Pancreas	KP2	8.5
Pancreas	KP3	7.1
Pancreas	KP4	8.3
Pancreas	L33	7.9
Pancreas	MIAPACA2	8.4
Pancreas	PANC0203	8.6
Pancreas	PANC0213	8.6
Pancreas	PANC0327	8.1
Pancreas	PANC0403	7.1
Pancreas	PANC0504	7.9
Pancreas	PANC0813	8.5
Pancreas	PANC1005	8.5
Pancreas	PANC1	7.2
Pancreas	PATU8902	8.1
Pancreas	PATU8988S	8.2
Pancreas	PATU8988T	8.8
Pancreas	PK1	8.3
Pancreas	PK45H	8.3
Pancreas	PK59	9.2
Pancreas	PL45	8.1
Pancreas	PSN1	8.4
Pancreas	QGP1	9.2
Pancreas	SNU213	8.4
Pancreas	SNU324	8.1
Pancreas	SNU410	8.9
Pancreas	SU8686	8.4
Pancreas	SUIT2	8.4
Pancreas	SW1990	7.9
Pancreas	T3M4	8.1
Pancreas	TCCPAN2	7.7
Pancreas	YAPC	9.4
Pleura	ACCMESO1	7.5
Pleura	DM3	8.2
Pleura	ISTMES1	7.5
Pleura	ISTMES2	8.1
Pleura	JL1	8.5
Pleura	MPP89	8.3
Pleura	MSTO211H	8.2
Pleura	NCIH2052	8.3
Pleura	NCIH2452	7.3
Pleura	NCIH28	8.4
Prostate	22RV1	7.9
Prostate	DU145	8
Prostate	LNCAPCLONEFGC	8.9
Prostate	MDAPCA2B	8.6
Prostate	NCIH660	8.4
Prostate	PC3	6.9
Prostate	VCAP	8.3
Salivary gland	A253	9.2
Salivary gland	YD15	8.2
Skin	A101D	6.4
Skin	A2058	8.5
Skin	A375	8.1
Skin	C32	8.2
Skin	CHL1	8.2
Skin	CJM	9.4
Skin	COLO679	5.9
Skin	COLO741	8.1
Skin	COLO783	8.2
Skin	COLO792	8.1
Skin	COLO800	7.9
Skin	COLO818	7.9
Skin	COLO829	8.2
Skin	COLO849	8.3
Skin	G361	8.5
Skin	GRM	9.5
Skin	HMCB	9.1
Skin	HS294T	7
Skin	HS600T	7.5
Skin	HS688AT	8.2
Skin	HS695T	7.8
Skin	HS839T	7.9
Skin	HS852T	8.6
Skin	HS895T	7.5
Skin	HS934T	8.1
Skin	HS936T	7.8
Skin	HS939T	7.8
Skin	HS940T	8.1
Skin	HS944T	7.9
Skin	HT144	7.8
Skin	IGR1	7.8
Skin	IGR37	8.5
Skin	IGR39	8.6
Skin	IPC298	7.3
Skin	K029AX	7.8
Skin	LOXIMVI	8.1
Skin	MALME3M	7.3
Skin	MDAMB435S	8.3
Skin	MELHO	7.2
Skin	MELJUSO	7.8
Skin	MEWO	8.1
Skin	RPMI7951	7.8
Skin	RVH421	7.5
Skin	SH4	8.1
Skin	SKMEL1	7.1
Skin	SKMEL24	7.6
Skin	SKMEL28	7.4
Skin	SKMEL2	7.2
Skin	SKMEL30	7.7
Skin	SKMEL31	7.4
Skin	SKMEL3	7.4
Skin	SKMEL5	7.8
Skin	UACC257	6.9
Skin	UACC62	7.5
Skin	WM115	8.1
Skin	WM1799	8.5
Skin	WM2664	8.1
Skin	WM793	8.7
Skin	WM88	8.1
Skin	WM983B	8
Small intestine	HUTU80	8.5
Soft tissue	A204	8.2
Soft tissue	G401	7.5
Soft tissue	G402	8.4
Soft tissue	GCT	7.3
Soft tissue	HS729	8.4
Soft tissue	HT1080	7.5
Soft tissue	KYM1	8.2
Soft tissue	MESSA	8.1
Soft tissue	RD	9.1
Soft tissue	RH30	9.1
Soft tissue	RH41	9.6
Soft tissue	RKN	7.7
Soft tissue	S117	7.7
Soft tissue	SJRH30	8.7
Soft tissue	SKLMS1	8
Soft tissue	SKUT1	8.1
Soft tissue	TE125T	8.3
Soft tissue	TE159T	8.1
Soft tissue	TE441T	9.1
Soft tissue	TE617T	8.2
Stomach	2313287	8.3
Stomach	AGS	8
Stomach	AZ521	8.6
Stomach	ECC10	9.6
Stomach	ECC12	8.8
Stomach	FU97	6.7
Stomach	GCIY	5.9
Stomach	GSS	8.8
Stomach	GSU	8.3
Stomach	HGC27	8.9
Stomach	HS746T	8.6
Stomach	HUG1N	7.6
Stomach	IM95	7.8
Stomach	KATOIII	7.9
Stomach	KE39	8.1
Stomach	LMSU	8
Stomach	MKN1	8
Stomach	MKN45	8
Stomach	MKN74	9.3
Stomach	MKN7	8.8
Stomach	NCCSTCK140	9.3
Stomach	NCIN87	8.7
Stomach	NUGC2	9.4
Stomach	NUGC3	7.8
Stomach	NUGC4	7.8
Stomach	OCUM1	8
Stomach	RERFGC1B	7.9
Stomach	SH10TC	8.4
Stomach	SNU16	8.2
Stomach	SNU1	8.2
Stomach	SNU216	9.1
Stomach	SNU520	8.7
Stomach	SNU5	7.9
Stomach	SNU601	7.8
Stomach	SNU620	9.5
Stomach	SNU668	8.3
Stomach	SNU719	8.9
Stomach	TGBC11TKB	7.7
Thyroid	8305C	9.2
Thyroid	8505C	8.7
Thyroid	BCPAP	8.2
Thyroid	BHT101	7.3
Thyroid	CAL62	9
Thyroid	CGTHW1	8.8
Thyroid	FTC133	8.5
Thyroid	FTC238	8.3
Thyroid	ML1	8.2
Thyroid	SW579	8
Thyroid	TT2609C02	9.2
Thyroid	TT	8.4
Upper aerodigestive tract	BHY	8.6
Upper aerodigestive tract	BICR16	8.6
Upper aerodigestive tract	BICR18	8.4
Upper aerodigestive tract	BICR22	9
Upper aerodigestive tract	BICR31	8.5
Upper aerodigestive tract	BICR56	7.9
Upper aerodigestive tract	BICR6	8.9
Upper aerodigestive tract	CAL27	8.4
Upper aerodigestive tract	CAL33	9.4
Upper aerodigestive tract	DETROIT562	8.1
Upper aerodigestive tract	FADU	8.5
Upper aerodigestive tract	HS840T	7.8
Upper aerodigestive tract	HSC2	7.8
Upper aerodigestive tract	HSC3	7.5
Upper aerodigestive tract	HSC4	9
Upper aerodigestive tract	PECAPJ15	9.5
Upper aerodigestive tract	PECAPJ34CLONEC12	9.4
Upper aerodigestive tract	PECAPJ41CLONED2	8.2
Upper aerodigestive tract	PECAPJ49	8.7
Upper aerodigestive tract	SCC15	8.9
Upper aerodigestive tract	SCC25	8.9
Upper aerodigestive tract	SCC4	7.4
Upper aerodigestive tract	SCC9	7.8
Upper aerodigestive tract	SNU1076	9.1
Upper aerodigestive tract	SNU1214	9.3
Upper aerodigestive tract	SNU46	8.7
Upper aerodigestive tract	SNU899	8.8
Upper aerodigestive tract	YD10B	8.6
Upper aerodigestive tract	YD38	7.6
Upper aerodigestive tract	YD8	8.8
Urinary tract	5637	8.5
Urinary tract	639V	7.7
Urinary tract	647V	8.5
Urinary tract	BC3C	8.7
Urinary tract	BFTC905	8.9
Urinary tract	CAL29	8.8
Urinary tract	HS172T	8.4
Urinary tract	HT1197	8.5
Urinary tract	HT1376	9.2
Urinary tract	J82	8
Urinary tract	JMSU1	9.1
Urinary tract	KMBC2	9.2
Urinary tract	KU1919	8.2
Urinary tract	RT11284	9.1
Urinary tract	RT112	8.6
Urinary tract	RT4	8.5
Urinary tract	SCABER	7.3
Urinary tract	SW1710	8.9
Urinary tract	SW780	9
Urinary tract	T24	8.2
Urinary tract	TCCSUP	8.8
Urinary tract	UMUC1	8.7
Urinary tract	UMUC3	8
Urinary tract	VMCUB1	9.1

> The Human Protein Atlas (HPA)

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Tissue	Expression Level (TPM)
Adipose tissue	17.3
Adrenal gland	16.2
Appendix	15.9
Bone marrow	10.8
Breast	15.3
Cerebral cortex	22.6
Cervix, uterine	23.2
Colon	10.6
Duodenum	10.4
Endometrium	30.6
Epididymis	15.8
Esophagus	13.9
Fallopian tube	25.2
Gallbladder	18.5
Heart muscle	11.4
Kidney	8.1
Liver	3.7
Lung	23.8
Lymph node	15.2
Ovary	27.8
Pancreas	3.4
Parathyroid gland	29.9
Placenta	22.3
Prostate	23.4
Rectum	10.1
Salivary gland	7.6
Seminal vesicle	24.5
Skeletal muscle	9.7
Skin	22.8
Small intestine	13.6
Smooth muscle	20.7
Spleen	28.3
Stomach	12.9
Testis	14.9
Thyroid gland	25.3
Tonsil	9.3
Urinary bladder	14.1

> Text Mining based Expression

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PMID	Expression	Cancer	Evidence
25043306	Underexpression	Colon Carcinoma; Gastric Carcinoma	PHF2 was downregulated in cancer tissues and PHF2 correlated with p21 in cancers expressing functional p53. Informatics analyses using the Oncomine database also supported our notion that PHF2 is downregulated in colon and stomach cancers.
22534467	Overexpression	Oesophagal Squamous Cell Carcinoma	Our results showed that JARID1B and PHF2 were overexpressed in ESCCs. Kaplan-Meier survival analysis showed a tendency that high cytoplasmic expression of JARID1B and PHF2 was associated with decreased overall survival of ESCC patients, whereas JARID1B high expression in the nucleus was associated with high overall survival, although there was no statistical significance.
28607325	Underexpression	Renal Cell Carcinoma	High expression of PHF2 was significantly correlated with a low Fuhrman nuclear grade (p<.001), smaller tumor size (p<.001), low overall stage (p=.003), longer cancer-specific survival (p=.002), and progression-free survival (p<.001) of the patients. Our study showed that low expression of PHF2 is associated with aggressiveness and poor prognosis of CCRCC.

Summary
Symbol	PHF2
Name	PHD finger protein 2
Aliases	KIAA0662; JHDM1E; CENP-35; jumonji C domain-containing histone demethylase 1E; centromere protein 35; GRC5; ......
Location	9q22.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

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Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.31	1.92e-10	43.1	41.1	15.8	Loss
BRCA	Breast invasive carcinoma	1075	0.53	8.66e-79	27.9	59.4	12.7	Neutral
CESC	Cervical and endocervical cancers	292	0.383	1.29e-11	18.8	63	18.2	Neutral
COAD	Colon adenocarcinoma	449	0.343	8.32e-14	13.8	70.8	15.4	Neutral
ESCA	Esophageal carcinoma	183	0.632	8.17e-22	31.1	42.1	26.8	Neutral
GBM	Glioblastoma multiforme	147	0.445	1.63e-08	14.3	71.4	14.3	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.381	3.19e-19	12.8	55.3	31.9	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.453	7.2e-28	28.2	69.3	2.5	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.188	0.00135	11.8	87.5	0.7	Neutral
LAML	Acute Myeloid Leukemia	166	0.407	5.16e-08	2.4	97	0.6	Neutral
LGG	Brain Lower Grade Glioma	513	0.31	6.94e-13	9	85.6	5.5	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.368	4.17e-13	31.6	62.1	6.3	Neutral
LUAD	Lung adenocarcinoma	512	0.476	2.27e-30	49	44.9	6.1	Loss
LUSC	Lung squamous cell carcinoma	498	0.574	5.47e-45	45.6	34.3	20.1	Loss
OV	Ovarian serous cystadenocarcinoma	300	0.641	3.64e-36	53	36	11	Loss
PAAD	Pancreatic adenocarcinoma	177	0.548	2.82e-15	23.2	71.8	5.1	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.29	0.000184	8	90.1	1.9	Neutral
PRAD	Prostate adenocarcinoma	491	0.207	3.9e-06	2.6	86.2	11.2	Neutral
READ	Rectum adenocarcinoma	164	0.387	3.03e-07	17.1	62.8	20.1	Neutral
SARC	Sarcoma	255	0.222	0.000346	9.8	52.9	37.3	Gain
SKCM	Skin Cutaneous Melanoma	367	0.524	3.22e-27	49.3	44.4	6.3	Loss
STAD	Stomach adenocarcinoma	413	0.435	1.83e-20	24.2	56.2	19.6	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.336	2.6e-05	37.3	48	14.7	Loss
THCA	Thyroid carcinoma	497	0.386	3.87e-19	5.2	94	0.8	Neutral
THYM	Thymoma	119	0.183	0.0463	2.5	89.1	8.4	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.388	8.79e-21	24.8	73	2.2	Neutral

Summary
Symbol	PHF2
Name	PHD finger protein 2
Aliases	KIAA0662; JHDM1E; CENP-35; jumonji C domain-containing histone demethylase 1E; centromere protein 35; GRC5; ......
Location	9q22.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.131	0.00695	17	408	0.086	0.00377	NS/NA
BRCA	Breast invasive carcinoma	-0.276	1.52e-16	83	785	0.107	4.6e-29	NS/NA
CESC	Cervical and endocervical cancers	-0.158	0.00539	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.117	0.0381	19	297	0.193	1.44e-15	NS/NA
ESCA	Esophageal carcinoma	-0.046	0.523	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.386	0.00162	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.034	0.428	20	522	0.257	1.41e-17	Increased
KIRC	Kidney renal clear cell carcinoma	-0.402	6.34e-15	24	319	0.149	6.07e-17	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.291	3.74e-07	23	275	0.198	1.03e-18	NS/NA
LAML	Acute Myeloid Leukemia	-0.021	0.781	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	0.091	0.0372	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.05	0.312	41	373	0.07	2.91e-06	NS/NA
LUAD	Lung adenocarcinoma	-0.266	4.12e-09	21	456	0.181	2.37e-19	NS/NA
LUSC	Lung squamous cell carcinoma	-0.176	0.00061	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.683	0.0503	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	0.006	0.936	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.416	4.64e-09	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.345	2.56e-16	35	498	0.089	6.3e-19	NS/NA
READ	Rectum adenocarcinoma	-0.104	0.301	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.522	0	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.085	0.0652	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.046	0.38	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.197	0.0138	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.15	0.000366	50	509	0.131	5.76e-13	NS/NA
THYM	Thymoma	-0.253	0.00509	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.28	9.96e-10	34	431	0.075	1.73e-10	NS/NA

Summary
Symbol	PHF2
Name	PHD finger protein 2
Aliases	KIAA0662; JHDM1E; CENP-35; jumonji C domain-containing histone demethylase 1E; centromere protein 35; GRC5; ......
Location	9q22.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	3	High
Appendix	3	High
Bone marrow	3	High
Breast	3	High
Bronchus	3	High
Caudate	3	High
Cerebellum	3	High
Cerebral cortex	3	High
Cervix, uterine	3	High
Colon	3	High
Duodenum	3	High
Endometrium	3	High
Epididymis	3	High
Esophagus	3	High
Fallopian tube	3	High
Gallbladder	3	High
Heart muscle	3	High
Hippocampus	3	High
Kidney	3	High
Liver	3	High
Lung	3	High
Lymph node	2	Medium
Nasopharynx	3	High
Oral mucosa	3	High
Ovary	3	High
Pancreas	3	High
Parathyroid gland	3	High
Placenta	3	High
Prostate	3	High
Rectum	3	High
Salivary gland	3	High
Seminal vesicle	3	High
Skeletal muscle	3	High
Skin	3	High
Small intestine	3	High
Smooth muscle	3	High
Soft tissue	3	High
Spleen	3	High
Stomach	3	High
Testis	3	High
Thyroid gland	3	High
Tonsil	3	High
Urinary bladder	3	High
Vagina	3	High

Summary
Symbol	PHF2
Name	PHD finger protein 2
Aliases	KIAA0662; JHDM1E; CENP-35; jumonji C domain-containing histone demethylase 1E; centromere protein 35; GRC5; ......
Location	9q22.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.589	NS	24476821
BRCA	Breast invasive carcinoma	521	2.29e-10	Significant	23000897
COAD	Colon adenocarcinoma	149	0.566	NS	22810696
GBM	Glioblastoma multiforme	157	1.21e-05	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	9.52e-10	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.0223	Significant	26536169
LGG	Brain Lower Grade Glioma	513	1.1e-18	Significant	26824661
LUAD	Lung adenocarcinoma	230	5.16e-05	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	7.62e-05	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.000276	Significant	21720365
PRAD	Prostate adenocarcinoma	333	2.54e-25	Significant	26544944
READ	Rectum adenocarcinoma	67	0.694	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.665	NS	26091043
STAD	Stomach adenocarcinoma	277	9.92e-09	Significant	25079317
THCA	Thyroid carcinoma	391	0.923	NS	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	1.24e-06	Significant	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	0.892	0.58	NS
BRCA	Breast invasive carcinoma	1079	1.061	0.794	NS
CESC	Cervical and endocervical cancers	291	1.067	0.841	NS
COAD	Colon adenocarcinoma	439	1.438	0.218	NS
ESCA	Esophageal carcinoma	184	0.651	0.189	NS
GBM	Glioblastoma multiforme	158	0.962	0.864	NS
HNSC	Head and Neck squamous cell carcinoma	518	1.042	0.831	NS
KIRC	Kidney renal clear cell carcinoma	531	0.659	0.0566	NS
KIRP	Kidney renal papillary cell carcinoma	287	0.539	0.196	NS
LAML	Acute Myeloid Leukemia	149	0.895	0.706	NS
LGG	Brain Lower Grade Glioma	511	0.404	0.00016	Longer
LIHC	Liver hepatocellular carcinoma	365	0.566	0.028	Longer
LUAD	Lung adenocarcinoma	502	0.85	0.464	NS
LUSC	Lung squamous cell carcinoma	494	1.112	0.607	NS
OV	Ovarian serous cystadenocarcinoma	303	1.142	0.52	NS
PAAD	Pancreatic adenocarcinoma	177	0.756	0.343	NS
PCPG	Pheochromocytoma and Paraganglioma	179	1	1	NS
PRAD	Prostate adenocarcinoma	497	1.543	0.605	NS
READ	Rectum adenocarcinoma	159	1.75	0.31	NS
SARC	Sarcoma	259	1.023	0.937	NS
SKCM	Skin Cutaneous Melanoma	459	1.047	0.802	NS
STAD	Stomach adenocarcinoma	388	0.906	0.652	NS
TGCT	Testicular Germ Cell Tumors	134	594299978.097	0.317	NS
THCA	Thyroid carcinoma	500	0.67	0.598	NS
THYM	Thymoma	119	0.613	0.522	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	0.721	0.271	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	-0.056	0.262	NS
BRCA	Breast invasive carcinoma	1071	-0.049	0.106	NS
CESC	Cervical and endocervical cancers	167	-0.02	0.801	NS
COAD	Colon adenocarcinoma	445	0.131	0.00568	Higher
ESCA	Esophageal carcinoma	162	-0.085	0.282	NS
HNSC	Head and Neck squamous cell carcinoma	448	0.083	0.0798	NS
KIRC	Kidney renal clear cell carcinoma	531	-0.14	0.00117	Lower
KIRP	Kidney renal papillary cell carcinoma	260	-0.039	0.535	NS
LIHC	Liver hepatocellular carcinoma	347	0.055	0.305	NS
LUAD	Lung adenocarcinoma	507	0.002	0.96	NS
LUSC	Lung squamous cell carcinoma	497	0.018	0.697	NS
OV	Ovarian serous cystadenocarcinoma	302	0.033	0.566	NS
PAAD	Pancreatic adenocarcinoma	176	-0.19	0.0114	Lower
READ	Rectum adenocarcinoma	156	0.156	0.0512	NS
SKCM	Skin Cutaneous Melanoma	410	-0.068	0.172	NS
STAD	Stomach adenocarcinoma	392	0.024	0.638	NS
TGCT	Testicular Germ Cell Tumors	81	-0.336	0.00215	Lower
THCA	Thyroid carcinoma	499	-0.062	0.163	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	-0.08	0.0746	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	-0.072	0.237	NS
HNSC	Head and Neck squamous cell carcinoma	498	0.183	4.03e-05	Higher
KIRC	Kidney renal clear cell carcinoma	525	-0.204	2.35e-06	Lower
LGG	Brain Lower Grade Glioma	514	-0.018	0.688	NS
LIHC	Liver hepatocellular carcinoma	366	0.001	0.991	NS
OV	Ovarian serous cystadenocarcinoma	296	-0.147	0.0113	Lower
PAAD	Pancreatic adenocarcinoma	176	-0.118	0.12	NS
STAD	Stomach adenocarcinoma	406	0.056	0.258	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	-0.221	2.42e-07	Lower

Summary
Symbol	PHF2
Name	PHD finger protein 2
Aliases	KIAA0662; JHDM1E; CENP-35; jumonji C domain-containing histone demethylase 1E; centromere protein 35; GRC5; ......
Location	9q22.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	PHF2
Name	PHD finger protein 2
Aliases	KIAA0662; JHDM1E; CENP-35; jumonji C domain-containing histone demethylase 1E; centromere protein 35; GRC5; ......
Location	9q22.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for PHF2.

Summary
Symbol	PHF2
Name	PHD finger protein 2
Aliases	KIAA0662; JHDM1E; CENP-35; jumonji C domain-containing histone demethylase 1E; centromere protein 35; GRC5; ......
Location	9q22.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
25043306	Colon Carcinoma; Gastric Carcinoma	partner	p21	correlation	Colon and stomach cancer tissue arrays showed a positive correlation between PHF2 and p21 expressions.