CR2Cancer

Summary
Symbol	PSIP1
Name	PC4 and SFRS1 interacting protein 1
Aliases	LEDGF; PSIP2; PC4 and SFRS1 interacting protein 2; DFS70; PAIP; CLL-associated antigen KW-7; DFS 70; dense f ......
Location	9p22.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

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Domain

PF11467 Lens epithelium-derived growth factor (LEDGF)
PF00855 PWWP domain

Function

Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration.

Classification

Class	Modification	Substrate	Product	PubMed
Chromatin remodelling	#	#	#	21720545

> Gene Ontology [ TOP ]
Biological Process	GO:0000245 spliceosomal complex assembly GO:0000375 RNA splicing, via transesterification reactions GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile GO:0000395 mRNA 5'-splice site recognition GO:0000398 mRNA splicing, via spliceosome GO:0006376 mRNA splice site selection GO:0006397 mRNA processing GO:0006979 response to oxidative stress GO:0008380 RNA splicing GO:0009266 response to temperature stimulus GO:0009408 response to heat GO:0019042 viral latency GO:0019043 establishment of viral latency GO:0022613 ribonucleoprotein complex biogenesis GO:0022618 ribonucleoprotein complex assembly GO:0045292 mRNA cis splicing, via spliceosome GO:0051169 nuclear transport GO:0071826 ribonucleoprotein complex subunit organization GO:0075713 establishment of integrated proviral latency
Molecular Function	GO:0043566 structure-specific DNA binding GO:0097100 supercoiled DNA binding
Cellular Component	GO:0000785 chromatin GO:0035327 transcriptionally active chromatin

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-164843: 2-LTR circle formation R-HSA-180689: APOBEC3G mediated resistance to HIV-1 infection R-HSA-177539: Autointegration results in viral DNA circles R-HSA-1643685: Disease R-HSA-162594: Early Phase of HIV Life Cycle R-HSA-162906: HIV Infection R-HSA-162587: HIV Life Cycle R-HSA-162909: Host Interactions of HIV factors R-HSA-5663205: Infectious disease R-HSA-162592: Integration of provirus R-HSA-175567: Integration of viral DNA into host genomic DNA R-HSA-176033: Interactions of Vpr with host cellular proteins R-HSA-180910: Vpr-mediated nuclear import of PICs

> KEGG and Reactome Pathway

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KEGG

Reactome

R-HSA-164843: 2-LTR circle formation
R-HSA-180689: APOBEC3G mediated resistance to HIV-1 infection
R-HSA-177539: Autointegration results in viral DNA circles
R-HSA-1643685: Disease
R-HSA-162594: Early Phase of HIV Life Cycle
R-HSA-162906: HIV Infection
R-HSA-162587: HIV Life Cycle
R-HSA-162909: Host Interactions of HIV factors
R-HSA-5663205: Infectious disease
R-HSA-162592: Integration of provirus
R-HSA-175567: Integration of viral DNA into host genomic DNA
R-HSA-176033: Interactions of Vpr with host cellular proteins
R-HSA-180910: Vpr-mediated nuclear import of PICs

Summary
Symbol	PSIP1
Name	PC4 and SFRS1 interacting protein 1
Aliases	LEDGF; PSIP2; PC4 and SFRS1 interacting protein 2; DFS70; PAIP; CLL-associated antigen KW-7; DFS 70; dense f ......
Location	9p22.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]

> Catalogue of Somatic Mutations in Cancer (COSMIC)

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COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM4819032	c.452G>A	p.R151K	Substitution - Missense	Cervix
COSM1107423	c.361G>T	p.D121Y	Substitution - Missense	Endometrium
COSM3848175	c.859-1G>C	p.?	Unknown	Breast
COSM4967678	c.215_228>ATAAAAGGT	p.K75fs*2	Complex - frameshift	Pancreas
COSM1107419	c.663G>A	p.G221G	Substitution - coding silent	Endometrium
COSM1674392	c.176T>G	p.F59C	Substitution - Missense	Large_intestine
COSM246834	c.64C>T	p.P22S	Substitution - Missense	Prostate
COSM95649	c.160G>T	p.G54*	Substitution - Nonsense	Breast
COSM455703	c.833_835delAAG	p.E278delE	Deletion - In frame	Breast
COSM3656304	c.444G>A	p.G148G	Substitution - coding silent	Skin
COSM5472726	c.9C>T	p.R3R	Substitution - coding silent	Large_intestine
COSM1489868	c.288+1G>T	p.?	Unknown	Lung
COSM5410883	c.129C>T	p.F43F	Substitution - coding silent	Skin
COSM5063826	c.39C>A	p.A13A	Substitution - coding silent	Stomach
COSM1624814	c.161G>A	p.G54E	Substitution - Missense	Liver
COSM1107421	c.456+1G>T	p.?	Unknown	Endometrium
COSM3779895	c.331G>A	p.E111K	Substitution - Missense	Urinary_tract
COSM4889966	c.167A>G	p.K56R	Substitution - Missense	Upper_aerodigestive_tract
COSM4387147	c.952C>T	p.Q318*	Substitution - Nonsense	Lung
COSM1107427	c.208A>C	p.K70Q	Substitution - Missense	Endometrium
COSM4152220	c.185C>G	p.S62*	Substitution - Nonsense	Ovary
COSM1756087	c.56C>T	p.P19L	Substitution - Missense	Skin
COSM5602140	c.819C>T	p.S273S	Substitution - coding silent	Skin
COSM1489868	c.288+1G>T	p.?	Unknown	Breast
COSM1107413	c.889G>A	p.A297T	Substitution - Missense	Endometrium
COSM4387055	c.540_541delAG	p.G181fs*28	Deletion - Frameshift	Lung
COSM5410886	c.63G>A	p.W21*	Substitution - Nonsense	Skin
COSM1461545	c.86C>A	p.P29H	Substitution - Missense	Large_intestine
COSM4718411	c.211C>T	p.P71S	Substitution - Missense	Large_intestine
COSM1107431	c.112A>C	p.N38H	Substitution - Missense	Endometrium
COSM5656032	c.831A>G	p.E277E	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM1756087	c.56C>T	p.P19L	Substitution - Missense	Urinary_tract
COSM4993318	c.868G>A	p.G290S	Substitution - Missense	Skin
COSM455705	c.399G>C	p.V133V	Substitution - coding silent	Breast
COSM1666099	c.172_173insA	p.I58fs*8	Insertion - Frameshift	Kidney
COSM4152220	c.185C>G	p.S62*	Substitution - Nonsense	Ovary
COSM1107409	c.961C>A	p.Q321K	Substitution - Missense	Endometrium
COSM3090589	c.222_226delAAAAG	p.K75fs*2	Deletion - Frameshift	Stomach
COSM5165412	c.115_118delAAAC	p.K39fs*14	Deletion - Frameshift	Large_intestine
COSM1674392	c.176T>G	p.F59C	Substitution - Missense	Large_intestine
COSM1107429	c.149C>T	p.T50I	Substitution - Missense	Endometrium
COSM1107413	c.889G>A	p.A297T	Substitution - Missense	Endometrium
COSM1489870	c.246G>T	p.W82C	Substitution - Missense	Breast
COSM3906280	c.544C>T	p.R182*	Substitution - Nonsense	Stomach
COSM3779892	c.853G>A	p.E285K	Substitution - Missense	Urinary_tract
COSM455703	c.833_835delAAG	p.E278delE	Deletion - In frame	Large_intestine
COSM3395715	c.286C>T	p.Q96*	Substitution - Nonsense	Pancreas
COSM1107411	c.940C>T	p.R314*	Substitution - Nonsense	Skin
COSM1461543	c.485C>T	p.A162V	Substitution - Missense	Large_intestine
COSM1107411	c.940C>T	p.R314*	Substitution - Nonsense	Urinary_tract
COSM1107417	c.820G>A	p.D274N	Substitution - Missense	Endometrium
COSM4993321	c.394-1G>A	p.?	Unknown	Skin
COSM4929037	c.149+1G>T	p.?	Unknown	Liver
COSM3090601	c.150-1G>T	p.?	Unknown	Urinary_tract
COSM3090554	c.753_754insA	p.E252fs*7	Insertion - Frameshift	Large_intestine
COSM4822740	c.262C>T	p.P88S	Substitution - Missense	Cervix
COSM1624814	c.161G>A	p.G54E	Substitution - Missense	Liver
COSM3090565	c.486A>C	p.A162A	Substitution - coding silent	Large_intestine
COSM3952591	c.288G>T	p.Q96H	Substitution - Missense	Lung
COSM1107415	c.875G>T	p.R292M	Substitution - Missense	Endometrium
COSM3848172	c.883C>G	p.Q295E	Substitution - Missense	Breast
COSM455703	c.833_835delAAG	p.E278delE	Deletion - In frame	Large_intestine
COSM3906277	c.659A>G	p.K220R	Substitution - Missense	Stomach
COSM4966033	c.858G>A	p.K286K	Substitution - coding silent	Pancreas
COSM4981436	c.928G>A	p.E310K	Substitution - Missense	Oesophagus
COSM1756087	c.56C>T	p.P19L	Substitution - Missense	Urinary_tract
COSM3906274	c.946C>T	p.R316C	Substitution - Missense	Stomach
COSM3952587	c.595A>G	p.M199V	Substitution - Missense	Lung
COSM1107411	c.940C>T	p.R314*	Substitution - Nonsense	Endometrium
COSM4635720	c.274T>A	p.F92I	Substitution - Missense	Large_intestine
COSM487287	c.731C>A	p.P244Q	Substitution - Missense	Kidney
COSM1489872	c.158_159insT	p.L53fs*13	Insertion - Frameshift	Breast
COSM5126216	c.158delT	p.L53fs*1	Deletion - Frameshift	Breast
COSM4431023	c.172A>T	p.I58L	Substitution - Missense	Oesophagus
COSM1107425	c.230T>G	p.F77C	Substitution - Missense	Endometrium
COSM1263252	c.796A>T	p.K266*	Substitution - Nonsense	Oesophagus
COSM4718408	c.708G>T	p.E236D	Substitution - Missense	Large_intestine
COSM5547046	c.552_553+25del27	p.?	Unknown	Prostate

> Text Mining based Variations

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PMID	Variation	Cancer	Evidence
15982735	mutation	Chronic Myeloid Leukemia	This is the first description of NUP98-LEDGF in CML and strengthens the association between disease progression in and NUP98 abnormalities.
15725483	mutation	Acute Myeloid Leukemia	We report a novel fusion of the NUP98 and LEDGF genes in a pediatric AML with intermediate characteristics between M2-M3 French-American-British (FAB) subtypes exhibiting the same chromosomal rearrangement.
11737860	mutation	Acute Myeloid Leukemia	A NUP98-LEDGF fusion transcript was observed and confirmed by sequencing. The breakpoints in the NUP98 and LEDGF genes were different to those previously reported.

Summary
Symbol	PSIP1
Name	PC4 and SFRS1 interacting protein 1
Aliases	LEDGF; PSIP2; PC4 and SFRS1 interacting protein 2; DFS70; PAIP; CLL-associated antigen KW-7; DFS 70; dense f ......
Location	9p22.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

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Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
O75475	105	S	Phosphoserine	-	No	None detected
O75475	106	S	Phosphoserine	-	No	None detected
O75475	115	T	Phosphothreonine	-	No	None detected
O75475	122	T	Phosphothreonine	-	No	None detected
O75475	129	S	Phosphoserine	-	No	None detected
O75475	141	T	Phosphothreonine	-	No	None detected
O75475	167	T	Phosphothreonine	-	No	None detected
O75475	177	S	Phosphoserine	-	No	None detected
O75475	206	S	Phosphoserine	-	No	None detected
O75475	271	S	Phosphoserine	-	No	None detected
O75475	272	T	Phosphothreonine	-	Yes	p.T272fs (cancer: BLCA)
O75475	273	S	Phosphoserine	-	No	None detected
O75475	275	S	Phosphoserine	-	No	None detected
O75475	434	S	Phosphoserine	-	No	None detected
O75475	437	T	Phosphothreonine	-	No	None detected
O75475	443	S	Phosphoserine	-	Yes	p.S443Y (cancer: COAD)
O75475	514	S	Phosphoserine	-	No	None detected
O75475	517	R	Citrulline	-	Yes	p.R517T (cancer: HNSC)
O75475	522	S	Phosphoserine	-	No	None detected
O75475	527	T	Phosphothreonine	-	No	None detected

Summary
Symbol	PSIP1
Name	PC4 and SFRS1 interacting protein 1
Aliases	LEDGF; PSIP2; PC4 and SFRS1 interacting protein 2; DFS70; PAIP; CLL-associated antigen KW-7; DFS 70; dense f ......
Location	9p22.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

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Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	5.97	5.483	-0.687	0.0093	Under
BRCA	Breast invasive carcinoma	112	1100	6.223	5.728	-0.395	1.33e-06	NS
CESC	Cervical and endocervical cancers	3	306	6.86	6.421	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	5.555	5.612	-0.174	0.213	NS
ESCA	Esophageal carcinoma	11	185	6.091	5.561	-0.455	0.103	NS
GBM	Glioblastoma multiforme	5	166	7.561	7.008	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	4.869	4.881	0.103	0.537	NS
KIRC	Kidney renal clear cell carcinoma	72	534	6.392	6.259	-0.177	0.00271	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	6.028	5.554	-0.523	2.19e-06	NS
LAML	Acute Myeloid Leukemia	0	173	NA	7.186	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	7.78	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	4.511	4.548	0.189	0.133	NS
LUAD	Lung adenocarcinoma	59	517	6.217	5.495	-0.619	6.02e-11	Under
LUSC	Lung squamous cell carcinoma	51	501	6.075	5.647	-0.41	0.000601	NS
OV	Ovarian serous cystadenocarcinoma	0	307	NA	6.455	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	5.476	5.221	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	5.516	7.38	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	6.22	5.541	-0.71	2.09e-22	Under
READ	Rectum adenocarcinoma	10	167	6.191	5.686	-0.667	0.0293	Under
SARC	Sarcoma	2	263	6.244	6.578	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	6.828	5.626	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	5.455	5.815	-0.05	0.732	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	7.241	NA	NA	NA
THCA	Thyroid carcinoma	59	509	6.34	6.227	-0.163	0.000442	NS
THYM	Thymoma	2	120	7.886	8.022	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	6.918	5.999	-0.988	2.78e-10	Under

> Cancer Cell Line Encyclopedia (CCLE)

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Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	11.4
Autonomic ganglia	CHP212	10.7
Autonomic ganglia	IMR32	11.3
Autonomic ganglia	KELLY	11.2
Autonomic ganglia	KPNRTBM1	11.3
Autonomic ganglia	KPNSI9S	9.4
Autonomic ganglia	KPNYN	11.6
Autonomic ganglia	MHHNB11	10.7
Autonomic ganglia	NB1	10.7
Autonomic ganglia	NH6	11.2
Autonomic ganglia	SHSY5Y	11.1
Autonomic ganglia	SIMA	11.6
Autonomic ganglia	SKNAS	9
Autonomic ganglia	SKNBE2	11.2
Autonomic ganglia	SKNDZ	10.8
Autonomic ganglia	SKNFI	11.3
Autonomic ganglia	SKNSH	10.4
Biliary tract	HUCCT1	9.4
Biliary tract	HUH28	9.6
Biliary tract	SNU1079	10.4
Biliary tract	SNU1196	9.8
Biliary tract	SNU245	8.6
Biliary tract	SNU308	9.1
Biliary tract	SNU478	8.6
Bone	143B	11.2
Bone	A673	10.2
Bone	CADOES1	11.6
Bone	CAL78	9.2
Bone	G292CLONEA141B1	9.5
Bone	HOS	10.6
Bone	HS706T	9.9
Bone	HS737T	9
Bone	HS819T	9.1
Bone	HS821T	9.9
Bone	HS822T	8.8
Bone	HS863T	9.5
Bone	HS870T	9.9
Bone	HS888T	10.2
Bone	MG63	12.7
Bone	MHHES1	11.7
Bone	OUMS27	8.8
Bone	RDES	9.4
Bone	SJSA1	9.1
Bone	SKES1	10.5
Bone	SKNMC	11.6
Bone	SW1353	9.6
Bone	T173	10
Bone	TC71	10.7
Bone	U2OS	10.2
Breast	AU565	9.2
Breast	BT20	10
Breast	BT474	7.9
Breast	BT483	9.2
Breast	BT549	10.9
Breast	CAL120	10.6
Breast	CAL148	9.5
Breast	CAL51	11.4
Breast	CAL851	10.3
Breast	CAMA1	9.6
Breast	DU4475	11
Breast	EFM192A	8.9
Breast	EFM19	9.9
Breast	EVSAT	9.2
Breast	HCC1143	8.7
Breast	HCC1187	9.5
Breast	HCC1395	10
Breast	HCC1419	7.7
Breast	HCC1428	7.2
Breast	HCC1500	9
Breast	HCC1569	9.3
Breast	HCC1599	10.4
Breast	HCC1806	8.9
Breast	HCC1937	9.9
Breast	HCC1954	10.9
Breast	HCC202	9.9
Breast	HCC2157	10.6
Breast	HCC2218	7.3
Breast	HCC38	10.2
Breast	HCC70	10.7
Breast	HDQP1	10
Breast	HMC18	10.6
Breast	HS274T	10.1
Breast	HS281T	9.6
Breast	HS343T	9.9
Breast	HS578T	9.5
Breast	HS606T	9.6
Breast	HS739T	9.3
Breast	HS742T	8.5
Breast	JIMT1	10.4
Breast	KPL1	9.6
Breast	MCF7	9.4
Breast	MDAMB134VI	11
Breast	MDAMB157	10.7
Breast	MDAMB175VII	8.6
Breast	MDAMB231	8.7
Breast	MDAMB361	8.7
Breast	MDAMB415	8.8
Breast	MDAMB436	9.5
Breast	MDAMB453	8.4
Breast	MDAMB468	9.3
Breast	SKBR3	9.4
Breast	T47D	9
Breast	UACC812	9.6
Breast	UACC893	8
Breast	YMB1	8.1
Breast	ZR751	9
Breast	ZR7530	9.2
Central nervous system	1321N1	10.8
Central nervous system	42MGBA	3.9
Central nervous system	8MGBA	10.1
Central nervous system	A172	10.6
Central nervous system	AM38	9.9
Central nervous system	BECKER	6.3
Central nervous system	CAS1	10.1
Central nervous system	CCFSTTG1	10.2
Central nervous system	D283MED	11.4
Central nervous system	D341MED	10.2
Central nervous system	DAOY	9.1
Central nervous system	DBTRG05MG	10.1
Central nervous system	DKMG	9.2
Central nervous system	GAMG	9.8
Central nervous system	GB1	8.7
Central nervous system	GI1	10.3
Central nervous system	GMS10	10.1
Central nervous system	GOS3	10.6
Central nervous system	H4	10.4
Central nervous system	HS683	9.9
Central nervous system	KALS1	10.6
Central nervous system	KG1C	10.7
Central nervous system	KNS42	10.4
Central nervous system	KNS60	10.6
Central nervous system	KNS81	10.8
Central nervous system	KS1	10.2
Central nervous system	LN18	9.9
Central nervous system	LN229	10.9
Central nervous system	M059K	9.7
Central nervous system	MOGGCCM	10.6
Central nervous system	MOGGUVW	9.1
Central nervous system	NMCG1	10.2
Central nervous system	ONS76	10.1
Central nervous system	SF126	9.8
Central nervous system	SF295	9.9
Central nervous system	SNB19	10.6
Central nervous system	SNU1105	9.7
Central nervous system	SNU201	10.7
Central nervous system	SNU466	8.3
Central nervous system	SNU489	9.8
Central nervous system	SNU626	10.9
Central nervous system	SNU738	9.5
Central nervous system	SW1088	9.9
Central nervous system	SW1783	10
Central nervous system	T98G	9.2
Central nervous system	TM31	9.8
Central nervous system	U118MG	9.6
Central nervous system	U138MG	9.9
Central nervous system	U251MG	10.9
Central nervous system	U87MG	9.2
Central nervous system	YH13	9.8
Central nervous system	YKG1	10.5
Endometrium	AN3CA	10.5
Endometrium	COLO684	11.7
Endometrium	EFE184	9.7
Endometrium	EN	10.8
Endometrium	ESS1	10.6
Endometrium	HEC108	10.2
Endometrium	HEC151	10.2
Endometrium	HEC1A	10.1
Endometrium	HEC1B	11.4
Endometrium	HEC251	9.9
Endometrium	HEC265	10.1
Endometrium	HEC50B	9.5
Endometrium	HEC59	10.7
Endometrium	HEC6	10.4
Endometrium	ISHIKAWAHERAKLIO02ER	10.5
Endometrium	JHUEM1	10
Endometrium	JHUEM2	10.7
Endometrium	JHUEM3	9.4
Endometrium	KLE	9.2
Endometrium	MFE280	10.4
Endometrium	MFE296	10.7
Endometrium	MFE319	9.3
Endometrium	RL952	9.6
Endometrium	SNGM	10.6
Endometrium	SNU1077	9.6
Endometrium	SNU685	10.3
Endometrium	TEN	9.6
Haematopoietic and lymphoid	697	11.2
Haematopoietic and lymphoid	A3KAW	9.6
Haematopoietic and lymphoid	A4FUK	9.6
Haematopoietic and lymphoid	ALLSIL	11.8
Haematopoietic and lymphoid	AML193	10.2
Haematopoietic and lymphoid	AMO1	10.5
Haematopoietic and lymphoid	BCP1	10.2
Haematopoietic and lymphoid	BDCM	11.6
Haematopoietic and lymphoid	BL41	10.4
Haematopoietic and lymphoid	BL70	10.9
Haematopoietic and lymphoid	BV173	11.2
Haematopoietic and lymphoid	CA46	10.9
Haematopoietic and lymphoid	CI1	11
Haematopoietic and lymphoid	CMK115	9.9
Haematopoietic and lymphoid	CMK86	9.4
Haematopoietic and lymphoid	CMK	10
Haematopoietic and lymphoid	CMLT1	11.2
Haematopoietic and lymphoid	COLO775	8.7
Haematopoietic and lymphoid	DAUDI	11.4
Haematopoietic and lymphoid	DB	11.4
Haematopoietic and lymphoid	DEL	10.7
Haematopoietic and lymphoid	DND41	11
Haematopoietic and lymphoid	DOHH2	11.4
Haematopoietic and lymphoid	EB1	11.6
Haematopoietic and lymphoid	EB2	12.1
Haematopoietic and lymphoid	EHEB	11.2
Haematopoietic and lymphoid	EJM	10.5
Haematopoietic and lymphoid	EM2	10.2
Haematopoietic and lymphoid	EOL1	10.9
Haematopoietic and lymphoid	F36P	10.2
Haematopoietic and lymphoid	GA10	10.5
Haematopoietic and lymphoid	GDM1	11.3
Haematopoietic and lymphoid	GRANTA519	11.9
Haematopoietic and lymphoid	HDLM2	11.7
Haematopoietic and lymphoid	HDMYZ	10.5
Haematopoietic and lymphoid	HEL9217	12.5
Haematopoietic and lymphoid	HEL	12.8
Haematopoietic and lymphoid	HH	11.1
Haematopoietic and lymphoid	HL60	8.6
Haematopoietic and lymphoid	HPBALL	11.1
Haematopoietic and lymphoid	HS604T	8.7
Haematopoietic and lymphoid	HS611T	11.3
Haematopoietic and lymphoid	HS616T	9
Haematopoietic and lymphoid	HS751T	9.8
Haematopoietic and lymphoid	HT	11.7
Haematopoietic and lymphoid	HTK	11.1
Haematopoietic and lymphoid	HUNS1	11.3
Haematopoietic and lymphoid	HUT102	10.4
Haematopoietic and lymphoid	HUT78	10.2
Haematopoietic and lymphoid	JEKO1	9.6
Haematopoietic and lymphoid	JK1	10.8
Haematopoietic and lymphoid	JM1	11.1
Haematopoietic and lymphoid	JURKAT	11.4
Haematopoietic and lymphoid	JURLMK1	10.5
Haematopoietic and lymphoid	JVM2	12.1
Haematopoietic and lymphoid	JVM3	11.9
Haematopoietic and lymphoid	K562	10.7
Haematopoietic and lymphoid	KARPAS299	11.3
Haematopoietic and lymphoid	KARPAS422	10.7
Haematopoietic and lymphoid	KARPAS620	10
Haematopoietic and lymphoid	KASUMI1	9.9
Haematopoietic and lymphoid	KASUMI2	10.9
Haematopoietic and lymphoid	KASUMI6	10.7
Haematopoietic and lymphoid	KCL22	11.7
Haematopoietic and lymphoid	KE37	12
Haematopoietic and lymphoid	KE97	11.8
Haematopoietic and lymphoid	KG1	11.2
Haematopoietic and lymphoid	KHM1B	8.5
Haematopoietic and lymphoid	KIJK	10.9
Haematopoietic and lymphoid	KMH2	11.2
Haematopoietic and lymphoid	KMM1	10.4
Haematopoietic and lymphoid	KMS11	10.1
Haematopoietic and lymphoid	KMS12BM	10.8
Haematopoietic and lymphoid	KMS18	12.3
Haematopoietic and lymphoid	KMS20	10.1
Haematopoietic and lymphoid	KMS21BM	7.9
Haematopoietic and lymphoid	KMS26	10.3
Haematopoietic and lymphoid	KMS27	10.1
Haematopoietic and lymphoid	KMS28BM	10.6
Haematopoietic and lymphoid	KMS34	10.2
Haematopoietic and lymphoid	KO52	10.1
Haematopoietic and lymphoid	KOPN8	11.1
Haematopoietic and lymphoid	KU812	10
Haematopoietic and lymphoid	KYO1	9.7
Haematopoietic and lymphoid	L1236	11.2
Haematopoietic and lymphoid	L363	9.8
Haematopoietic and lymphoid	L428	10.8
Haematopoietic and lymphoid	L540	12.3
Haematopoietic and lymphoid	LAMA84	10.8
Haematopoietic and lymphoid	LOUCY	11.6
Haematopoietic and lymphoid	LP1	10.1
Haematopoietic and lymphoid	M07E	11.2
Haematopoietic and lymphoid	MC116	10.8
Haematopoietic and lymphoid	ME1	9.4
Haematopoietic and lymphoid	MEC1	12.2
Haematopoietic and lymphoid	MEC2	11.3
Haematopoietic and lymphoid	MEG01	9.5
Haematopoietic and lymphoid	MHHCALL2	11.3
Haematopoietic and lymphoid	MHHCALL3	10.4
Haematopoietic and lymphoid	MHHCALL4	11.4
Haematopoietic and lymphoid	MINO	10.3
Haematopoietic and lymphoid	MJ	10.9
Haematopoietic and lymphoid	MM1S	9.4
Haematopoietic and lymphoid	MOLM13	9.7
Haematopoietic and lymphoid	MOLM16	10.1
Haematopoietic and lymphoid	MOLM6	10
Haematopoietic and lymphoid	MOLP2	9.9
Haematopoietic and lymphoid	MOLP8	10.5
Haematopoietic and lymphoid	MOLT13	11.3
Haematopoietic and lymphoid	MOLT16	11.4
Haematopoietic and lymphoid	MOLT4	11
Haematopoietic and lymphoid	MONOMAC1	10.7
Haematopoietic and lymphoid	MONOMAC6	11.5
Haematopoietic and lymphoid	MOTN1	11
Haematopoietic and lymphoid	MUTZ5	11.2
Haematopoietic and lymphoid	MV411	9.8
Haematopoietic and lymphoid	NALM19	10.4
Haematopoietic and lymphoid	NALM1	11.8
Haematopoietic and lymphoid	NALM6	11.5
Haematopoietic and lymphoid	NAMALWA	11.2
Haematopoietic and lymphoid	NB4	11.7
Haematopoietic and lymphoid	NCIH929	8.2
Haematopoietic and lymphoid	NCO2	10.9
Haematopoietic and lymphoid	NOMO1	9.5
Haematopoietic and lymphoid	NUDHL1	10.6
Haematopoietic and lymphoid	NUDUL1	11.2
Haematopoietic and lymphoid	OCIAML2	10.7
Haematopoietic and lymphoid	OCIAML3	10.5
Haematopoietic and lymphoid	OCIAML5	10.4
Haematopoietic and lymphoid	OCILY10	10.9
Haematopoietic and lymphoid	OCILY19	10.2
Haematopoietic and lymphoid	OCILY3	10.6
Haematopoietic and lymphoid	OCIM1	10.8
Haematopoietic and lymphoid	OPM2	10.6
Haematopoietic and lymphoid	P12ICHIKAWA	11
Haematopoietic and lymphoid	P31FUJ	10.7
Haematopoietic and lymphoid	P3HR1	10.9
Haematopoietic and lymphoid	PCM6	9.3
Haematopoietic and lymphoid	PEER	11.2
Haematopoietic and lymphoid	PF382	12.2
Haematopoietic and lymphoid	PFEIFFER	10.7
Haematopoietic and lymphoid	PL21	11.2
Haematopoietic and lymphoid	RAJI	11
Haematopoietic and lymphoid	RCHACV	11.1
Haematopoietic and lymphoid	REC1	10
Haematopoietic and lymphoid	REH	10.7
Haematopoietic and lymphoid	RI1	10.9
Haematopoietic and lymphoid	RL	10.9
Haematopoietic and lymphoid	RPMI8226	9
Haematopoietic and lymphoid	RPMI8402	12.2
Haematopoietic and lymphoid	RS411	10.8
Haematopoietic and lymphoid	SEM	11.3
Haematopoietic and lymphoid	SET2	9.6
Haematopoietic and lymphoid	SIGM5	10.1
Haematopoietic and lymphoid	SKM1	10.7
Haematopoietic and lymphoid	SKMM2	9.2
Haematopoietic and lymphoid	SR786	10.1
Haematopoietic and lymphoid	ST486	10.5
Haematopoietic and lymphoid	SUDHL10	11.3
Haematopoietic and lymphoid	SUDHL1	10.8
Haematopoietic and lymphoid	SUDHL4	11
Haematopoietic and lymphoid	SUDHL5	11.7
Haematopoietic and lymphoid	SUDHL6	12
Haematopoietic and lymphoid	SUDHL8	11.1
Haematopoietic and lymphoid	SUPB15	10.5
Haematopoietic and lymphoid	SUPHD1	12.5
Haematopoietic and lymphoid	SUPM2	9.6
Haematopoietic and lymphoid	SUPT11	11.4
Haematopoietic and lymphoid	SUPT1	11.2
Haematopoietic and lymphoid	TALL1	12
Haematopoietic and lymphoid	TF1	10.7
Haematopoietic and lymphoid	THP1	10.2
Haematopoietic and lymphoid	TO175T	10.1
Haematopoietic and lymphoid	TOLEDO	10.6
Haematopoietic and lymphoid	U266B1	10
Haematopoietic and lymphoid	U937	10.3
Haematopoietic and lymphoid	UT7	12.6
Haematopoietic and lymphoid	WSUDLCL2	11.7
Kidney	769P	10.1
Kidney	786O	9.8
Kidney	A498	9.3
Kidney	A704	9
Kidney	ACHN	9.8
Kidney	BFTC909	10.7
Kidney	CAKI1	9.5
Kidney	CAKI2	9.5
Kidney	CAL54	9.9
Kidney	KMRC1	9.5
Kidney	KMRC20	10
Kidney	KMRC2	8.9
Kidney	KMRC3	9.4
Kidney	OSRC2	9
Kidney	RCC10RGB	9.4
Kidney	SNU1272	10
Kidney	SNU349	4.9
Kidney	TUHR10TKB	9
Kidney	TUHR14TKB	9.2
Kidney	TUHR4TKB	9.9
Kidney	VMRCRCW	9
Kidney	VMRCRCZ	9.6
Large intestine	C2BBE1	8.3
Large intestine	CCK81	10
Large intestine	CL11	10.6
Large intestine	CL14	9.5
Large intestine	CL34	10.1
Large intestine	CL40	8.5
Large intestine	COLO205	8.8
Large intestine	COLO320	11.4
Large intestine	COLO678	10.1
Large intestine	CW2	9.8
Large intestine	DLD1	10.8
Large intestine	GP2D	9.6
Large intestine	HCC56	9.4
Large intestine	HCT116	10.2
Large intestine	HCT15	10.9
Large intestine	HS675T	9.3
Large intestine	HS698T	9.9
Large intestine	HT115	8.7
Large intestine	HT29	9.9
Large intestine	HT55	9
Large intestine	KM12	10.5
Large intestine	LOVO	10.1
Large intestine	LS1034	9
Large intestine	LS123	9.1
Large intestine	LS180	10
Large intestine	LS411N	10.6
Large intestine	LS513	9
Large intestine	MDST8	9.1
Large intestine	NCIH508	8.3
Large intestine	NCIH716	9.2
Large intestine	NCIH747	9.7
Large intestine	OUMS23	8.5
Large intestine	RCM1	9.2
Large intestine	RKO	10.2
Large intestine	SKCO1	10.1
Large intestine	SNU1040	9.4
Large intestine	SNU1197	9
Large intestine	SNU175	9.7
Large intestine	SNU283	9.9
Large intestine	SNU407	9.5
Large intestine	SNU503	9.3
Large intestine	SNU61	8.9
Large intestine	SNU81	9.5
Large intestine	SNUC1	9
Large intestine	SNUC2A	8.5
Large intestine	SNUC4	9.6
Large intestine	SNUC5	11.2
Large intestine	SW1116	8.8
Large intestine	SW1417	9.9
Large intestine	SW1463	9.5
Large intestine	SW403	9.2
Large intestine	SW480	10.1
Large intestine	SW48	10.7
Large intestine	SW620	9.9
Large intestine	SW837	10.4
Large intestine	SW948	9.5
Large intestine	T84	7.1
Liver	ALEXANDERCELLS	8.5
Liver	C3A	8.6
Liver	HEP3B217	10.4
Liver	HEPG2	9
Liver	HLE	10
Liver	HLF	10
Liver	HUH1	6.8
Liver	HUH6	9.3
Liver	HUH7	9.3
Liver	JHH1	9.7
Liver	JHH2	7.9
Liver	JHH4	10.3
Liver	JHH5	8.9
Liver	JHH6	10
Liver	JHH7	9.9
Liver	LI7	10
Liver	PLCPRF5	8
Liver	SKHEP1	9.8
Liver	SNU182	9.8
Liver	SNU387	9.8
Liver	SNU398	11
Liver	SNU423	10.1
Liver	SNU449	9.3
Liver	SNU475	10
Liver	SNU761	9.1
Liver	SNU878	8.5
Liver	SNU886	9.2
Lung	A549	9.3
Lung	ABC1	8.9
Lung	BEN	7.9
Lung	CAL12T	8.4
Lung	CALU1	10
Lung	CALU3	9.5
Lung	CALU6	10.3
Lung	CHAGOK1	9.5
Lung	COLO668	10.8
Lung	COLO699	9.8
Lung	CORL105	8.8
Lung	CORL23	9.1
Lung	CORL24	11.3
Lung	CORL279	11.8
Lung	CORL311	10.6
Lung	CORL47	11.7
Lung	CORL51	11.8
Lung	CORL88	11.6
Lung	CORL95	11.5
Lung	CPCN	11.9
Lung	DMS114	10.8
Lung	DMS153	11.5
Lung	DMS273	10.9
Lung	DMS454	9.6
Lung	DMS53	8.2
Lung	DMS79	12
Lung	DV90	9.9
Lung	EBC1	8.2
Lung	EPLC272H	8.6
Lung	HARA	9.4
Lung	HCC1171	8.4
Lung	HCC1195	9
Lung	HCC15	9.1
Lung	HCC2279	7.1
Lung	HCC2935	8.5
Lung	HCC33	12.4
Lung	HCC366	10
Lung	HCC4006	9.3
Lung	HCC44	9.6
Lung	HCC78	9.6
Lung	HCC827	10
Lung	HCC95	9.4
Lung	HLC1	9.3
Lung	HLFA	9.1
Lung	HS229T	10.1
Lung	HS618T	9.3
Lung	IALM	10
Lung	KNS62	8.4
Lung	LC1F	9.5
Lung	LC1SQSF	10.5
Lung	LCLC103H	10
Lung	LCLC97TM1	9.6
Lung	LK2	10.8
Lung	LOUNH91	9.7
Lung	LU65	9.2
Lung	LU99	10.7
Lung	LUDLU1	7.9
Lung	LXF289	10.8
Lung	MORCPR	8.6
Lung	NCIH1048	11.3
Lung	NCIH1092	12.2
Lung	NCIH1105	13.2
Lung	NCIH1155	11.1
Lung	NCIH1184	12.2
Lung	NCIH1299	10
Lung	NCIH1339	10.1
Lung	NCIH1341	10.5
Lung	NCIH1355	9.7
Lung	NCIH1373	10.1
Lung	NCIH1385	9.9
Lung	NCIH1395	7
Lung	NCIH1435	8.7
Lung	NCIH1436	12
Lung	NCIH1437	8.3
Lung	NCIH146	11.3
Lung	NCIH1563	9.1
Lung	NCIH1568	9.2
Lung	NCIH1573	6.9
Lung	NCIH1581	10.3
Lung	NCIH1618	11.9
Lung	NCIH1623	8
Lung	NCIH1648	7.2
Lung	NCIH1650	9.8
Lung	NCIH1651	8.3
Lung	NCIH1666	9.1
Lung	NCIH1693	9.4
Lung	NCIH1694	10.9
Lung	NCIH1703	9.7
Lung	NCIH1734	9.7
Lung	NCIH1755	8.1
Lung	NCIH1781	9.6
Lung	NCIH1792	9
Lung	NCIH1793	10.2
Lung	NCIH1836	11.8
Lung	NCIH1838	8.3
Lung	NCIH1869	9
Lung	NCIH1876	12.6
Lung	NCIH1915	8.8
Lung	NCIH1930	12.1
Lung	NCIH1944	9.2
Lung	NCIH1963	12.4
Lung	NCIH196	10.3
Lung	NCIH1975	8.5
Lung	NCIH2009	10.2
Lung	NCIH2023	8.1
Lung	NCIH2029	10.3
Lung	NCIH2030	7.8
Lung	NCIH2066	9.5
Lung	NCIH2081	12.1
Lung	NCIH2085	8.5
Lung	NCIH2087	9.4
Lung	NCIH209	11.4
Lung	NCIH2106	11.9
Lung	NCIH2110	9.2
Lung	NCIH211	10
Lung	NCIH2122	8.6
Lung	NCIH2126	7.7
Lung	NCIH2141	12.7
Lung	NCIH2170	10
Lung	NCIH2171	10.8
Lung	NCIH2172	9.6
Lung	NCIH2196	12.4
Lung	NCIH2227	11.2
Lung	NCIH2228	9.3
Lung	NCIH226	9.7
Lung	NCIH2286	10.1
Lung	NCIH2291	8.5
Lung	NCIH2342	8.5
Lung	NCIH2347	8.2
Lung	NCIH23	6.6
Lung	NCIH2405	9.8
Lung	NCIH2444	9
Lung	NCIH292	9.3
Lung	NCIH322	9.4
Lung	NCIH3255	9.4
Lung	NCIH358	10
Lung	NCIH441	8.8
Lung	NCIH446	11.9
Lung	NCIH460	9.6
Lung	NCIH510	10.1
Lung	NCIH520	10.4
Lung	NCIH522	10.1
Lung	NCIH524	10.9
Lung	NCIH526	11.8
Lung	NCIH596	10.3
Lung	NCIH647	10.1
Lung	NCIH650	10.1
Lung	NCIH661	10.3
Lung	NCIH69	11.8
Lung	NCIH727	8.8
Lung	NCIH810	10.3
Lung	NCIH82	10.6
Lung	NCIH838	10.5
Lung	NCIH841	11.5
Lung	NCIH854	7.3
Lung	NCIH889	12.5
Lung	PC14	9.2
Lung	RERFLCAD1	9.7
Lung	RERFLCAD2	8.6
Lung	RERFLCAI	9.1
Lung	RERFLCKJ	8.5
Lung	RERFLCMS	9.6
Lung	RERFLCSQ1	9.4
Lung	SBC5	10.9
Lung	SCLC21H	11.5
Lung	SHP77	9.7
Lung	SKLU1	9.7
Lung	SKMES1	9.4
Lung	SQ1	7.6
Lung	SW1271	9.5
Lung	SW1573	11.2
Lung	SW900	9.8
Lung	VMRCLCD	8.1
Lung	VMRCLCP	5.5
Oesophagus	COLO680N	9.3
Oesophagus	ECGI10	9.8
Oesophagus	KYSE140	9.6
Oesophagus	KYSE150	9.7
Oesophagus	KYSE180	9.4
Oesophagus	KYSE270	9.1
Oesophagus	KYSE30	8.5
Oesophagus	KYSE410	9.6
Oesophagus	KYSE450	10.9
Oesophagus	KYSE510	10.4
Oesophagus	KYSE520	9.1
Oesophagus	KYSE70	10.9
Oesophagus	OE19	4.9
Oesophagus	OE33	9.7
Oesophagus	TE10	7.7
Oesophagus	TE11	9.6
Oesophagus	TE14	8.9
Oesophagus	TE15	9.8
Oesophagus	TE1	9.8
Oesophagus	TE4	7.7
Oesophagus	TE5	9.7
Oesophagus	TE6	10.2
Oesophagus	TE8	11.4
Oesophagus	TE9	8.7
Oesophagus	TT	9.1
Ovary	59M	8.7
Ovary	A2780	11.4
Ovary	CAOV3	9.4
Ovary	CAOV4	9.4
Ovary	COLO704	11.2
Ovary	COV318	10
Ovary	COV362	9.6
Ovary	COV434	11
Ovary	COV504	10.2
Ovary	COV644	8.5
Ovary	EFO21	8.9
Ovary	EFO27	9
Ovary	ES2	10.6
Ovary	FUOV1	11.2
Ovary	HEYA8	10.7
Ovary	HS571T	8.7
Ovary	IGROV1	10.4
Ovary	JHOC5	9.8
Ovary	JHOM1	9.3
Ovary	JHOM2B	10.2
Ovary	JHOS2	9
Ovary	JHOS4	9.5
Ovary	KURAMOCHI	10.4
Ovary	MCAS	9.5
Ovary	NIHOVCAR3	10.7
Ovary	OAW28	10.6
Ovary	OAW42	9.9
Ovary	OC314	10.5
Ovary	OC316	10.1
Ovary	ONCODG1	10.9
Ovary	OV56	9.5
Ovary	OV7	10
Ovary	OV90	9.6
Ovary	OVCAR4	8.4
Ovary	OVCAR8	10.6
Ovary	OVISE	9.6
Ovary	OVK18	9.9
Ovary	OVKATE	9.1
Ovary	OVMANA	9.2
Ovary	OVSAHO	10.4
Ovary	OVTOKO	10.1
Ovary	RMGI	8.5
Ovary	RMUGS	6.1
Ovary	SKOV3	9.7
Ovary	SNU119	11.2
Ovary	SNU840	8.1
Ovary	SNU8	9.6
Ovary	TOV112D	11.7
Ovary	TOV21G	10.4
Ovary	TYKNU	9.6
Pancreas	ASPC1	7.9
Pancreas	BXPC3	8.1
Pancreas	CAPAN1	9.3
Pancreas	CAPAN2	9.2
Pancreas	CFPAC1	8.2
Pancreas	DANG	8.2
Pancreas	HPAC	10.1
Pancreas	HPAFII	8.6
Pancreas	HS766T	9.8
Pancreas	HUPT3	8.4
Pancreas	HUPT4	9.2
Pancreas	KCIMOH1	10.2
Pancreas	KLM1	8.7
Pancreas	KP2	10
Pancreas	KP3	9.7
Pancreas	KP4	11
Pancreas	L33	9.7
Pancreas	MIAPACA2	10.5
Pancreas	PANC0203	9.4
Pancreas	PANC0213	8.7
Pancreas	PANC0327	10.1
Pancreas	PANC0403	9.7
Pancreas	PANC0504	8.7
Pancreas	PANC0813	9.8
Pancreas	PANC1005	10.4
Pancreas	PANC1	8.5
Pancreas	PATU8902	10.9
Pancreas	PATU8988S	8.3
Pancreas	PATU8988T	10.5
Pancreas	PK1	9
Pancreas	PK45H	9.5
Pancreas	PK59	7.8
Pancreas	PL45	10.5
Pancreas	PSN1	8.6
Pancreas	QGP1	10.4
Pancreas	SNU213	7.7
Pancreas	SNU324	9.3
Pancreas	SNU410	9
Pancreas	SU8686	9.2
Pancreas	SUIT2	10.6
Pancreas	SW1990	9.6
Pancreas	T3M4	8.8
Pancreas	TCCPAN2	9
Pancreas	YAPC	9.8
Pleura	ACCMESO1	10.1
Pleura	DM3	8.5
Pleura	ISTMES1	9.2
Pleura	ISTMES2	9.2
Pleura	JL1	10.1
Pleura	MPP89	10.4
Pleura	MSTO211H	10.9
Pleura	NCIH2052	10.4
Pleura	NCIH2452	9.7
Pleura	NCIH28	9.6
Prostate	22RV1	10.4
Prostate	DU145	9.8
Prostate	LNCAPCLONEFGC	9.9
Prostate	MDAPCA2B	8.9
Prostate	NCIH660	11.1
Prostate	PC3	8.6
Prostate	VCAP	10.5
Salivary gland	A253	9.6
Salivary gland	YD15	9.8
Skin	A101D	9.2
Skin	A2058	10.8
Skin	A375	10.5
Skin	C32	8.6
Skin	CHL1	10.5
Skin	CJM	10.1
Skin	COLO679	8.9
Skin	COLO741	9.5
Skin	COLO783	9.5
Skin	COLO792	7.8
Skin	COLO800	10.1
Skin	COLO818	9.6
Skin	COLO829	8.1
Skin	COLO849	9.2
Skin	G361	9.5
Skin	GRM	9.2
Skin	HMCB	10.5
Skin	HS294T	8.9
Skin	HS600T	9.6
Skin	HS688AT	9.1
Skin	HS695T	9.8
Skin	HS839T	10
Skin	HS852T	8
Skin	HS895T	9.3
Skin	HS934T	10.7
Skin	HS936T	9.3
Skin	HS939T	9.4
Skin	HS940T	8.8
Skin	HS944T	9.6
Skin	HT144	9.5
Skin	IGR1	11
Skin	IGR37	8.4
Skin	IGR39	10.2
Skin	IPC298	9.3
Skin	K029AX	8.3
Skin	LOXIMVI	10.7
Skin	MALME3M	9.5
Skin	MDAMB435S	11
Skin	MELHO	9.5
Skin	MELJUSO	8.9
Skin	MEWO	9.8
Skin	RPMI7951	9.7
Skin	RVH421	9.7
Skin	SH4	9.7
Skin	SKMEL1	9.3
Skin	SKMEL24	8.7
Skin	SKMEL28	10.3
Skin	SKMEL2	9.6
Skin	SKMEL30	9.2
Skin	SKMEL31	8.9
Skin	SKMEL3	8.5
Skin	SKMEL5	9
Skin	UACC257	8.7
Skin	UACC62	9
Skin	WM115	8.7
Skin	WM1799	10.2
Skin	WM2664	8.9
Skin	WM793	9.1
Skin	WM88	8.5
Skin	WM983B	9.4
Small intestine	HUTU80	11
Soft tissue	A204	10.1
Soft tissue	G401	11
Soft tissue	G402	10.5
Soft tissue	GCT	9.7
Soft tissue	HS729	9.7
Soft tissue	HT1080	10.2
Soft tissue	KYM1	11.3
Soft tissue	MESSA	11.3
Soft tissue	RD	9.5
Soft tissue	RH30	9.3
Soft tissue	RH41	11.1
Soft tissue	RKN	11.1
Soft tissue	S117	11.2
Soft tissue	SJRH30	10.8
Soft tissue	SKLMS1	9.5
Soft tissue	SKUT1	10.8
Soft tissue	TE125T	10.6
Soft tissue	TE159T	9.9
Soft tissue	TE441T	11.7
Soft tissue	TE617T	11.2
Stomach	2313287	9.8
Stomach	AGS	9.6
Stomach	AZ521	10.9
Stomach	ECC10	11.9
Stomach	ECC12	10.5
Stomach	FU97	8.7
Stomach	GCIY	9.6
Stomach	GSS	9.7
Stomach	GSU	8.8
Stomach	HGC27	10.7
Stomach	HS746T	9.9
Stomach	HUG1N	9.9
Stomach	IM95	9.4
Stomach	KATOIII	9.9
Stomach	KE39	9.5
Stomach	LMSU	10.4
Stomach	MKN1	9.7
Stomach	MKN45	9
Stomach	MKN74	8.5
Stomach	MKN7	9.1
Stomach	NCCSTCK140	8.2
Stomach	NCIN87	10.3
Stomach	NUGC2	9.1
Stomach	NUGC3	9.6
Stomach	NUGC4	9.2
Stomach	OCUM1	8.8
Stomach	RERFGC1B	8.9
Stomach	SH10TC	9.3
Stomach	SNU16	9.7
Stomach	SNU1	11.5
Stomach	SNU216	9.6
Stomach	SNU520	9.2
Stomach	SNU5	8.7
Stomach	SNU601	9.6
Stomach	SNU620	10.5
Stomach	SNU668	9.5
Stomach	SNU719	9.5
Stomach	TGBC11TKB	10
Thyroid	8305C	11
Thyroid	8505C	10.7
Thyroid	BCPAP	9.2
Thyroid	BHT101	9.4
Thyroid	CAL62	11.9
Thyroid	CGTHW1	10.5
Thyroid	FTC133	9.7
Thyroid	FTC238	10.5
Thyroid	ML1	7.9
Thyroid	SW579	9
Thyroid	TT2609C02	10
Thyroid	TT	8.5
Upper aerodigestive tract	BHY	9.3
Upper aerodigestive tract	BICR16	7.5
Upper aerodigestive tract	BICR18	9.3
Upper aerodigestive tract	BICR22	8.1
Upper aerodigestive tract	BICR31	7.7
Upper aerodigestive tract	BICR56	7.2
Upper aerodigestive tract	BICR6	7.8
Upper aerodigestive tract	CAL27	9.3
Upper aerodigestive tract	CAL33	9.8
Upper aerodigestive tract	DETROIT562	9.4
Upper aerodigestive tract	FADU	11.5
Upper aerodigestive tract	HS840T	9.5
Upper aerodigestive tract	HSC2	9.6
Upper aerodigestive tract	HSC3	10.3
Upper aerodigestive tract	HSC4	10.3
Upper aerodigestive tract	PECAPJ15	9.2
Upper aerodigestive tract	PECAPJ34CLONEC12	9
Upper aerodigestive tract	PECAPJ41CLONED2	7.9
Upper aerodigestive tract	PECAPJ49	9.8
Upper aerodigestive tract	SCC15	8.8
Upper aerodigestive tract	SCC25	7.4
Upper aerodigestive tract	SCC4	7.6
Upper aerodigestive tract	SCC9	7.1
Upper aerodigestive tract	SNU1076	7.4
Upper aerodigestive tract	SNU1214	8.6
Upper aerodigestive tract	SNU46	9.8
Upper aerodigestive tract	SNU899	9.7
Upper aerodigestive tract	YD10B	10.3
Upper aerodigestive tract	YD38	10.1
Upper aerodigestive tract	YD8	10.7
Urinary tract	5637	9.6
Urinary tract	639V	11.4
Urinary tract	647V	10.1
Urinary tract	BC3C	10.3
Urinary tract	BFTC905	8.5
Urinary tract	CAL29	7.9
Urinary tract	HS172T	9.3
Urinary tract	HT1197	7.5
Urinary tract	HT1376	10.2
Urinary tract	J82	10.6
Urinary tract	JMSU1	11.6
Urinary tract	KMBC2	10.4
Urinary tract	KU1919	11.3
Urinary tract	RT11284	4.3
Urinary tract	RT112	4.2
Urinary tract	RT4	9.6
Urinary tract	SCABER	8.7
Urinary tract	SW1710	9.9
Urinary tract	SW780	8.4
Urinary tract	T24	10.1
Urinary tract	TCCSUP	10.7
Urinary tract	UMUC1	6.9
Urinary tract	UMUC3	11.4
Urinary tract	VMCUB1	10

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	37.1
Adrenal gland	53.5
Appendix	64.1
Bone marrow	38.2
Breast	33.5
Cerebral cortex	161.8
Cervix, uterine	57.7
Colon	30.5
Duodenum	23.6
Endometrium	95.4
Epididymis	47.3
Esophagus	29.2
Fallopian tube	66.9
Gallbladder	48.5
Heart muscle	24.1
Kidney	35.7
Liver	11.8
Lung	50.1
Lymph node	95.3
Ovary	106.8
Pancreas	3.5
Parathyroid gland	62.9
Placenta	58.5
Prostate	59.5
Rectum	38
Salivary gland	8.5
Seminal vesicle	59
Skeletal muscle	13.3
Skin	30.9
Small intestine	33.6
Smooth muscle	65.9
Spleen	77
Stomach	23.3
Testis	151
Thyroid gland	62.1
Tonsil	68.1
Urinary bladder	38.4

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
28633434	overexpression	Triple-Negative Breast Cancer	PSIP1/p75, previously identified as a chromatin-adaptor protein, is found to be upregulated in basal-like/triple negative breast cancer (TNBC) patient samples and cell lines.
28212536	overexpression	Prostate Carcinoma	Furthermore, LEDGF/p75 overexpression in PCa and other cancers has been associated with features of tumor aggressiveness, including resistance to cell death and chemotherapy.
26771192	Aberrant Expression	Prostate Carcinoma	This finding was consistent with the observation that while LEDGF/p75 was robustly cleaved in apoptotic cells into a p65 fragment that lacks stress survival activity, it remained relatively intact in necrotic cells.
22647853	Aberrant Expression	Prostate Carcinoma	Recently, aberrant expression of LEDGF was found in prostate cancer (PC).
21796653	Aberrant Expression	Prostate Carcinoma	Our validation data revealed that changes in LEDGF/p75 transcript and protein expression in PCa cells closely paralleled those of CYGB, but not those of the PRDXs.
19934313	Overexpression	Ovarian Carcinoma	Using chromatin immunoprecipitation, we showed that LEDGF/p75 indeed binds the VEGF-C promoter, and binding is augmented by FSH. A corresponding hormonally regulated increase in the LEDGF/p75 mRNA and protein levels was observed.
17451600	Overexpression	Acute Myeloid Leukemia	Analysis of blasts from single patients disclosed that LEDGF/p75 was the most consistently upregulated mRNA in resistant AML.
15389814	Aberrant Expression	Prostate Carcinoma	Apoptotic cleavage of LEDGF/p75 was detected by immunoblotting. LEDGF/p75 expression was detected in 93% of prostate tumors but not in normal prostate.

Summary
Symbol	PSIP1
Name	PC4 and SFRS1 interacting protein 1
Aliases	LEDGF; PSIP2; PC4 and SFRS1 interacting protein 2; DFS70; PAIP; CLL-associated antigen KW-7; DFS 70; dense f ......
Location	9p22.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.687	1.31e-57	46.5	34.2	19.3	Loss
BRCA	Breast invasive carcinoma	1075	0.448	3.31e-54	30.9	53.4	15.7	Neutral
CESC	Cervical and endocervical cancers	292	0.657	1.93e-37	18.5	61.3	20.2	Neutral
COAD	Colon adenocarcinoma	449	0.236	4.03e-07	13.4	68.8	17.8	Neutral
ESCA	Esophageal carcinoma	183	0.505	2.91e-13	58.5	29	12.6	Loss
GBM	Glioblastoma multiforme	147	0.72	8.98e-25	42.2	49	8.8	Loss
HNSC	Head and Neck squamous cell carcinoma	514	0.517	1.99e-36	41.6	36.4	22	Loss
KIRC	Kidney renal clear cell carcinoma	525	0.485	2.77e-32	28.4	69	2.7	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.161	0.00607	12.8	86.5	0.7	Neutral
LAML	Acute Myeloid Leukemia	166	0.217	0.00508	0.6	98.2	1.2	Neutral
LGG	Brain Lower Grade Glioma	513	0.666	5.98e-67	29	67.6	3.3	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.374	1.68e-13	33	61.3	5.8	Neutral
LUAD	Lung adenocarcinoma	512	0.564	2.58e-44	52.7	36.1	11.1	Loss
LUSC	Lung squamous cell carcinoma	498	0.6	5.45e-50	66.7	18.5	14.9	Loss
OV	Ovarian serous cystadenocarcinoma	300	0.722	1.52e-49	44.3	29	26.7	Loss
PAAD	Pancreatic adenocarcinoma	177	0.665	5.54e-24	47.5	48	4.5	Loss
PCPG	Pheochromocytoma and Paraganglioma	162	0.42	2.62e-08	8.6	88.9	2.5	Neutral
PRAD	Prostate adenocarcinoma	491	0.256	8.72e-09	7.1	86.4	6.5	Neutral
READ	Rectum adenocarcinoma	164	0.228	0.00334	15.9	56.7	27.4	Neutral
SARC	Sarcoma	255	0.473	1.35e-15	38.4	43.1	18.4	Loss
SKCM	Skin Cutaneous Melanoma	367	0.466	3.76e-21	68.1	25.9	6	Loss
STAD	Stomach adenocarcinoma	413	0.551	3.71e-34	40.2	48.2	11.6	Loss
TGCT	Testicular Germ Cell Tumors	150	0.398	4.7e-07	41.3	46.7	12	Loss
THCA	Thyroid carcinoma	497	0.357	1.98e-16	4	95.2	0.8	Neutral
THYM	Thymoma	119	0.236	0.0099	4.2	86.6	9.2	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.402	2.88e-22	14.7	76.4	8.9	Neutral

Summary
Symbol	PSIP1
Name	PC4 and SFRS1 interacting protein 1
Aliases	LEDGF; PSIP2; PC4 and SFRS1 interacting protein 2; DFS70; PAIP; CLL-associated antigen KW-7; DFS 70; dense f ......
Location	9p22.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.368	5.62e-15	17	408	0.01	2e-05	NS/NA
BRCA	Breast invasive carcinoma	-0.457	0	83	785	0.003	1.08e-14	NS/NA
CESC	Cervical and endocervical cancers	-0.212	0.000184	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.177	0.00158	19	297	0.001	0.0129	NS/NA
ESCA	Esophageal carcinoma	-0.174	0.0154	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.547	3.59e-06	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.298	1.77e-12	20	522	-0.034	0.0299	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.297	2.37e-08	24	319	0.022	0.000223	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.162	0.0052	23	275	0.001	0.0637	NS/NA
LAML	Acute Myeloid Leukemia	-0.066	0.39	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.304	1.08e-12	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.269	3.02e-08	41	373	-0.026	0.864	NS/NA
LUAD	Lung adenocarcinoma	-0.16	0.000441	21	456	0	0.619	NS/NA
LUSC	Lung squamous cell carcinoma	-0.242	2.11e-06	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.733	0.0311	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.337	3.54e-06	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.183	0.0125	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.359	5.8e-18	35	498	0.011	6.1e-18	NS/NA
READ	Rectum adenocarcinoma	-0.358	0.000257	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.341	1.68e-08	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.227	6.68e-07	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.242	2.4e-06	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.184	0.0213	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.071	0.0914	50	509	-0.001	0.326	NS/NA
THYM	Thymoma	-0.186	0.0408	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.111	0.0171	34	431	0.001	0.0232	NS/NA

Summary
Symbol	PSIP1
Name	PC4 and SFRS1 interacting protein 1
Aliases	LEDGF; PSIP2; PC4 and SFRS1 interacting protein 2; DFS70; PAIP; CLL-associated antigen KW-7; DFS 70; dense f ......
Location	9p22.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	2	Medium
Appendix	3	High
Bone marrow	2	Medium
Breast	2	Medium
Bronchus	2	Medium
Caudate	3	High
Cerebellum	3	High
Cerebral cortex	3	High
Cervix, uterine	2	Medium
Colon	3	High
Duodenum	3	High
Endometrium	3	High
Epididymis	2	Medium
Esophagus	3	High
Fallopian tube	2	Medium
Gallbladder	3	High
Heart muscle	2	Medium
Hippocampus	3	High
Kidney	2	Medium
Liver	2	Medium
Lung	2	Medium
Lymph node	3	High
Nasopharynx	3	High
Oral mucosa	2	Medium
Ovary	3	High
Pancreas	2	Medium
Parathyroid gland	2	Medium
Placenta	3	High
Prostate	2	Medium
Rectum	2	Medium
Salivary gland	3	High
Seminal vesicle	2	Medium
Skeletal muscle	2	Medium
Skin	2	Medium
Small intestine	3	High
Smooth muscle	2	Medium
Soft tissue	3	High
Spleen	3	High
Stomach	2	Medium
Testis	3	High
Thyroid gland	2	Medium
Tonsil	3	High
Urinary bladder	2	Medium
Vagina	2	Medium

Summary
Symbol	PSIP1
Name	PC4 and SFRS1 interacting protein 1
Aliases	LEDGF; PSIP2; PC4 and SFRS1 interacting protein 2; DFS70; PAIP; CLL-associated antigen KW-7; DFS 70; dense f ......
Location	9p22.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.0293	Significant	24476821
BRCA	Breast invasive carcinoma	521	5.73e-22	Significant	23000897
COAD	Colon adenocarcinoma	149	0.0544	NS	22810696
GBM	Glioblastoma multiforme	157	0.0509	NS	26824661
HNSC	Head and Neck squamous cell carcinoma	279	2.83e-08	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.939	NS	26536169
LGG	Brain Lower Grade Glioma	513	2.57e-12	Significant	26824661
LUAD	Lung adenocarcinoma	230	0.00398	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	5.1e-12	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	2.61e-08	Significant	21720365
PRAD	Prostate adenocarcinoma	333	0.00819	Significant	26544944
READ	Rectum adenocarcinoma	67	0.556	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.964	NS	26091043
STAD	Stomach adenocarcinoma	277	2.33e-07	Significant	25079317
THCA	Thyroid carcinoma	391	3.98e-12	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.313	NS	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	0.869	0.505	NS
BRCA	Breast invasive carcinoma	1079	0.895	0.631	NS
CESC	Cervical and endocervical cancers	291	0.503	0.0538	NS
COAD	Colon adenocarcinoma	439	0.867	0.626	NS
ESCA	Esophageal carcinoma	184	1.543	0.16	NS
GBM	Glioblastoma multiforme	158	1.006	0.98	NS
HNSC	Head and Neck squamous cell carcinoma	518	0.878	0.507	NS
KIRC	Kidney renal clear cell carcinoma	531	0.566	0.0104	Longer
KIRP	Kidney renal papillary cell carcinoma	287	2.305	0.0677	NS
LAML	Acute Myeloid Leukemia	149	1.158	0.624	NS
LGG	Brain Lower Grade Glioma	511	0.301	5.71e-07	Longer
LIHC	Liver hepatocellular carcinoma	365	1.425	0.151	NS
LUAD	Lung adenocarcinoma	502	0.865	0.485	NS
LUSC	Lung squamous cell carcinoma	494	0.79	0.221	NS
OV	Ovarian serous cystadenocarcinoma	303	0.876	0.529	NS
PAAD	Pancreatic adenocarcinoma	177	0.646	0.144	NS
PCPG	Pheochromocytoma and Paraganglioma	179	0.338	0.324	NS
PRAD	Prostate adenocarcinoma	497	2.74	0.399	NS
READ	Rectum adenocarcinoma	159	0.888	0.833	NS
SARC	Sarcoma	259	1.183	0.565	NS
SKCM	Skin Cutaneous Melanoma	459	0.641	0.0184	Longer
STAD	Stomach adenocarcinoma	388	0.973	0.908	NS
TGCT	Testicular Germ Cell Tumors	134	1.019	0.989	NS
THCA	Thyroid carcinoma	500	0.684	0.514	NS
THYM	Thymoma	119	0.89	0.91	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	1.66	0.101	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	0.082	0.0994	NS
BRCA	Breast invasive carcinoma	1071	-0.023	0.447	NS
CESC	Cervical and endocervical cancers	167	0.031	0.688	NS
COAD	Colon adenocarcinoma	445	-0.06	0.209	NS
ESCA	Esophageal carcinoma	162	0.143	0.0686	NS
HNSC	Head and Neck squamous cell carcinoma	448	-0.005	0.921	NS
KIRC	Kidney renal clear cell carcinoma	531	-0.135	0.00189	Lower
KIRP	Kidney renal papillary cell carcinoma	260	0.071	0.254	NS
LIHC	Liver hepatocellular carcinoma	347	0.075	0.163	NS
LUAD	Lung adenocarcinoma	507	-0.058	0.195	NS
LUSC	Lung squamous cell carcinoma	497	0.019	0.679	NS
OV	Ovarian serous cystadenocarcinoma	302	-0.088	0.127	NS
PAAD	Pancreatic adenocarcinoma	176	-0.215	0.00424	Lower
READ	Rectum adenocarcinoma	156	0.08	0.318	NS
SKCM	Skin Cutaneous Melanoma	410	-0.075	0.128	NS
STAD	Stomach adenocarcinoma	392	0.006	0.9	NS
TGCT	Testicular Germ Cell Tumors	81	-0.068	0.549	NS
THCA	Thyroid carcinoma	499	-0.072	0.108	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.12	0.00718	Higher

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	0.104	0.0881	NS
HNSC	Head and Neck squamous cell carcinoma	498	0.297	1.28e-11	Higher
KIRC	Kidney renal clear cell carcinoma	525	-0.254	3.44e-09	Lower
LGG	Brain Lower Grade Glioma	514	-0.197	6.73e-06	Lower
LIHC	Liver hepatocellular carcinoma	366	0.101	0.0547	NS
OV	Ovarian serous cystadenocarcinoma	296	0.102	0.0793	NS
PAAD	Pancreatic adenocarcinoma	176	-0.12	0.112	NS
STAD	Stomach adenocarcinoma	406	0.188	0.000143	Higher
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.303	7.84e-13	Higher

Summary
Symbol	PSIP1
Name	PC4 and SFRS1 interacting protein 1
Aliases	LEDGF; PSIP2; PC4 and SFRS1 interacting protein 2; DFS70; PAIP; CLL-associated antigen KW-7; DFS 70; dense f ......
Location	9p22.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	PSIP1
Name	PC4 and SFRS1 interacting protein 1
Aliases	LEDGF; PSIP2; PC4 and SFRS1 interacting protein 2; DFS70; PAIP; CLL-associated antigen KW-7; DFS 70; dense f ......
Location	9p22.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for PSIP1.

Summary
Symbol	PSIP1
Name	PC4 and SFRS1 interacting protein 1
Aliases	LEDGF; PSIP2; PC4 and SFRS1 interacting protein 2; DFS70; PAIP; CLL-associated antigen KW-7; DFS 70; dense f ......
Location	9p22.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

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PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
15982735	Chronic Myeloid Leukemia	partner	NUP98	Fusion	This is the first description of NUP98-LEDGF in CML and strengthens the association between disease progression in and NUP98 abnormalities.
15725483	Acute Myeloid Leukemia	partner	NUP98	Fusion	We report a novel fusion of the NUP98 and LEDGF genes in a pediatric AML with intermediate characteristics between M2-M3 French-American-British (FAB) subtypes exhibiting the same chromosomal rearrangement.
11737860	Acute Myeloid Leukemia	partner	NUP98	Fusion	Our results show that fusion of the NUP98 and LEDGF genes is a new recurrent translocation in AML.