Browse PYGO1 in pancancer

Summary
Symbol	PYGO1
Name	pygopus family PHD finger 1
Aliases	pygopus homolog 1 (Drosophila); pygopus-like protein 1; Pygopus homolog 1
Location	15q21.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

Domain

PF00628 PHD-finger

Function

Involved in signal transduction through the Wnt pathway.

Classification

Class	Modification	Substrate	Product	PubMed
#	#	#	#	#

> Gene Ontology [ TOP ]
Biological Process	GO:0001655 urogenital system development GO:0001822 kidney development GO:0002244 hematopoietic progenitor cell differentiation GO:0006997 nucleus organization GO:0007281 germ cell development GO:0007283 spermatogenesis GO:0007286 spermatid development GO:0007289 spermatid nucleus differentiation GO:0009791 post-embryonic development GO:0016055 Wnt signaling pathway GO:0022412 cellular process involved in reproduction in multicellular organism GO:0034504 protein localization to nucleus GO:0048232 male gamete generation GO:0048515 spermatid differentiation GO:0072001 renal system development GO:0198738 cell-cell signaling by wnt GO:1904837 beta-catenin-TCF complex assembly
Molecular Function	-
Cellular Component	-

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-3769402: Deactivation of the beta-catenin transactivating complex R-HSA-201722: Formation of the beta-catenin R-HSA-162582: Signal Transduction R-HSA-195721: Signaling by Wnt R-HSA-201681: TCF dependent signaling in response to WNT

Summary
Symbol	PYGO1
Name	pygopus family PHD finger 1
Aliases	pygopus homolog 1 (Drosophila); pygopus-like protein 1; Pygopus homolog 1
Location	15q21.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM1608494	c.453T>C	p.H151H	Substitution - coding silent	Liver
COSM3370211	c.430C>T	p.H144Y	Substitution - Missense	Thyroid
COSM963078	c.91C>A	p.Q31K	Substitution - Missense	Endometrium
COSM1373623	c.922C>T	p.R308*	Substitution - Nonsense	Large_intestine
COSM4425419	c.1177G>C	p.D393H	Substitution - Missense	Oesophagus
COSM3887206	c.866C>T	p.S289L	Substitution - Missense	Skin
COSM349066	c.1047G>T	p.E349D	Substitution - Missense	Lung
COSM4578349	c.49G>A	p.G17S	Substitution - Missense	Bone
COSM5027981	c.594C>T	p.P198P	Substitution - coding silent	Breast
COSM3502554	c.710C>T	p.P237L	Substitution - Missense	Skin
COSM4055771	c.723T>C	p.F241F	Substitution - coding silent	Stomach
COSM700912	c.507C>T	p.V169V	Substitution - coding silent	Lung
COSM963076	c.634T>G	p.F212V	Substitution - Missense	Endometrium
COSM4613019	c.710delC	p.P237fs*24	Deletion - Frameshift	Large_intestine
COSM700913	c.666T>C	p.F222F	Substitution - coding silent	Lung
COSM1493489	c.105A>G	p.P35P	Substitution - coding silent	Kidney
COSM3731918	c.50-5_50-3delTTT	p.?	Unknown	Large_intestine
COSM4504329	c.662C>G	p.S221C	Substitution - Missense	Skin
COSM2218395	c.17C>T	p.S6F	Substitution - Missense	Large_intestine
COSM963080	c.34A>T	p.K12*	Substitution - Nonsense	Endometrium
COSM1373624	c.824A>G	p.N275S	Substitution - Missense	Large_intestine
COSM4055769	c.1216A>G	p.T406A	Substitution - Missense	Stomach
COSM2218371	c.964delA	p.S322fs*29	Deletion - Frameshift	Large_intestine
COSM1222836	c.1180A>G	p.T394A	Substitution - Missense	Large_intestine
COSM4957656	c.663T>C	p.S221S	Substitution - coding silent	Liver
COSM5363047	c.1248C>A	p.G416G	Substitution - coding silent	Large_intestine
COSM5760325	c.124G>T	p.A42S	Substitution - Missense	Bone
COSM2157687	c.380_381insC	p.Q127fs*15	Insertion - Frameshift	Central_nervous_system
COSM4385888	c.50-2_50-1insT	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM253080	c.50-3delT	p.?	Unknown	Biliary_tract
COSM5946858	c.951C>A	p.C317*	Substitution - Nonsense	Haematopoietic_and_lymphoid_tissue
COSM963076	c.634T>G	p.F212V	Substitution - Missense	Endometrium
COSM5342589	c.1106G>A	p.R369Q	Substitution - Missense	Large_intestine
COSM4974533	c.1050G>A	p.V350V	Substitution - coding silent	Oesophagus
COSM3420456	c.439A>G	p.N147D	Substitution - Missense	Large_intestine
COSM4957656	c.663T>C	p.S221S	Substitution - coding silent	Liver
COSM1263635	c.94C>A	p.L32I	Substitution - Missense	Oesophagus
COSM3887205	c.1004C>T	p.S335L	Substitution - Missense	Skin
COSM253079	c.50-4_50-3delTT	p.?	Unknown	Large_intestine
COSM1666300	c.449C>A	p.P150Q	Substitution - Missense	Eye
COSM300626	c.1045G>A	p.E349K	Substitution - Missense	Pancreas
COSM5363047	c.1248C>A	p.G416G	Substitution - coding silent	Large_intestine
COSM253080	c.50-3delT	p.?	Unknown	Liver
COSM253079	c.50-4_50-3delTT	p.?	Unknown	Ovary
COSM4381212	c.755delA	p.N252fs*9	Deletion - Frameshift	Large_intestine
COSM4055772	c.472A>G	p.N158D	Substitution - Missense	Stomach
COSM2218371	c.964delA	p.S322fs*29	Deletion - Frameshift	Large_intestine
COSM2218373	c.832C>T	p.R278*	Substitution - Nonsense	Soft_tissue
COSM963071	c.1005G>A	p.S335S	Substitution - coding silent	Endometrium
COSM1629609	c.674C>T	p.P225L	Substitution - Missense	Liver
COSM963075	c.645G>A	p.P215P	Substitution - coding silent	Endometrium
COSM5813954	c.287C>T	p.P96L	Substitution - Missense	Liver
COSM2218384	c.280G>A	p.G94S	Substitution - Missense	Skin
COSM121691	c.909G>A	p.T303T	Substitution - coding silent	Upper_aerodigestive_tract
COSM276970	c.1196A>C	p.K399T	Substitution - Missense	Large_intestine
COSM963073	c.882C>T	p.A294A	Substitution - coding silent	Endometrium
COSM5821282	c.1065T>A	p.D355E	Substitution - Missense	Liver
COSM963079	c.86G>A	p.G29D	Substitution - Missense	Endometrium
COSM3502556	c.662C>T	p.S221F	Substitution - Missense	Skin
COSM78383	c.118C>T	p.R40C	Substitution - Missense	Stomach
COSM1608493	c.521A>T	p.Q174L	Substitution - Missense	Liver
COSM4128299	c.691C>G	p.Q231E	Substitution - Missense	Thyroid
COSM4600264	c.721T>G	p.F241V	Substitution - Missense	Upper_aerodigestive_tract
COSM2218373	c.832C>T	p.R278*	Substitution - Nonsense	Large_intestine
COSM253080	c.50-3delT	p.?	Unknown	Pancreas
COSM110534	c.953C>T	p.T318I	Substitution - Missense	Skin
COSM1287489	c.919C>T	p.P307S	Substitution - Missense	Autonomic_ganglia
COSM1608493	c.521A>T	p.Q174L	Substitution - Missense	Liver
COSM4982026	c.865T>C	p.S289P	Substitution - Missense	Oesophagus
COSM5818595	c.932G>A	p.R311K	Substitution - Missense	Liver
COSM963077	c.617C>A	p.P206H	Substitution - Missense	Endometrium
COSM4522651	c.1172G>A	p.G391D	Substitution - Missense	Skin
COSM2218376	c.686T>G	p.F229C	Substitution - Missense	Large_intestine
COSM4385888	c.50-2_50-1insT	p.?	Unknown	Large_intestine
COSM416887	c.119G>A	p.R40H	Substitution - Missense	Urinary_tract
COSM3816385	c.983A>C	p.H328P	Substitution - Missense	Breast
COSM2218395	c.17C>T	p.S6F	Substitution - Missense	Large_intestine
COSM300626	c.1045G>A	p.E349K	Substitution - Missense	Large_intestine
COSM253080	c.50-3delT	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM3887208	c.140C>T	p.P47L	Substitution - Missense	Skin
COSM1608494	c.453T>C	p.H151H	Substitution - coding silent	Liver
COSM416889	c.366C>A	p.Y122*	Substitution - Nonsense	Urinary_tract
COSM1373628	c.44C>T	p.S15L	Substitution - Missense	Large_intestine
COSM4055770	c.1117G>T	p.G373*	Substitution - Nonsense	Stomach
COSM470839	c.62G>A	p.G21E	Substitution - Missense	Kidney
COSM700914	c.1133C>A	p.A378D	Substitution - Missense	Lung
COSM2218380	c.552C>T	p.F184F	Substitution - coding silent	Skin
COSM253080	c.50-3delT	p.?	Unknown	Ovary
COSM4423365	c.50-3_50-2insT	p.?	Unknown	Central_nervous_system
COSM4831307	c.203C>A	p.A68D	Substitution - Missense	Cervix
COSM3887205	c.1004C>T	p.S335L	Substitution - Missense	Skin
COSM3887207	c.331C>T	p.P111S	Substitution - Missense	Skin
COSM700915	c.1182C>A	p.T394T	Substitution - coding silent	Lung
COSM4055773	c.403C>T	p.P135S	Substitution - Missense	Stomach
COSM963069	c.1213C>T	p.R405C	Substitution - Missense	Endometrium
COSM1663785	c.25C>T	p.P9S	Substitution - Missense	Kidney
COSM5789270	c.1029T>A	p.C343*	Substitution - Nonsense	Breast
COSM1222837	c.7G>A	p.A3T	Substitution - Missense	Large_intestine
COSM78383	c.118C>T	p.R40C	Substitution - Missense	Ovary
COSM470838	c.489T>C	p.N163N	Substitution - coding silent	Kidney
COSM3816386	c.368C>T	p.S123L	Substitution - Missense	Breast
COSM1373625	c.538C>T	p.P180S	Substitution - Missense	Large_intestine
COSM322940	c.1247G>A	p.G416D	Substitution - Missense	Lung
COSM5416448	c.725C>A	p.T242N	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3502555	c.671C>T	p.P224L	Substitution - Missense	Skin
COSM241326	c.683C>A	p.T228N	Substitution - Missense	Prostate
COSM3816387	c.290G>A	p.G97D	Substitution - Missense	Breast
COSM4055775	c.57T>C	p.D19D	Substitution - coding silent	Stomach
COSM963068	c.1222G>T	p.E408*	Substitution - Nonsense	Endometrium
COSM4055774	c.101G>A	p.S34N	Substitution - Missense	Stomach
COSM416888	c.284A>G	p.Y95C	Substitution - Missense	Urinary_tract
COSM6001656	c.1143C>G	p.L381L	Substitution - coding silent	Prostate
COSM5516054	c.718G>T	p.D240Y	Substitution - Missense	Biliary_tract
COSM963070	c.1105C>T	p.R369W	Substitution - Missense	Endometrium
COSM5625470	c.269A>G	p.Y90C	Substitution - Missense	Oesophagus
COSM4441374	c.952A>G	p.T318A	Substitution - Missense	Large_intestine
COSM1222837	c.7G>A	p.A3T	Substitution - Missense	Large_intestine
COSM963072	c.999C>T	p.G333G	Substitution - coding silent	Endometrium
COSM3744670	c.1257T>A	p.A419A	Substitution - coding silent	Liver
COSM963074	c.653C>A	p.S218Y	Substitution - Missense	Endometrium
COSM3731918	c.50-5_50-3delTTT	p.?	Unknown	Stomach

> Text Mining based Variations [ TOP ]
There is no record for PYGO1.

Summary
Symbol	PYGO1
Name	pygopus family PHD finger 1
Aliases	pygopus homolog 1 (Drosophila); pygopus-like protein 1; Pygopus homolog 1
Location	15q21.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM) [ TOP ]
There is no PTM data

Summary
Symbol	PYGO1
Name	pygopus family PHD finger 1
Aliases	pygopus homolog 1 (Drosophila); pygopus-like protein 1; Pygopus homolog 1
Location	15q21.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	0.08	-1.925	-2.098	0.000155	Under
BRCA	Breast invasive carcinoma	112	1100	0.774	-0.976	-1.648	5.21e-23	Under
CESC	Cervical and endocervical cancers	3	306	0.937	-2.263	NA	NA	NA
ESCA	Esophageal carcinoma	11	185	0.523	-0.135	-1.16	0.116	NS
GBM	Glioblastoma multiforme	5	166	-0.088	0.776	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	-0.6	-1.918	-1.422	4.14e-05	Under
KIRC	Kidney renal clear cell carcinoma	72	534	0.063	-2.207	-2.478	2.64e-29	Under
KIRP	Kidney renal papillary cell carcinoma	32	291	-0.464	-2.71	-2.158	6.27e-07	Under
LAML	Acute Myeloid Leukemia	0	173	NA	-3.809	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	1.637	NA	NA	NA
LUAD	Lung adenocarcinoma	59	517	0.382	-0.313	-0.915	2.59e-06	Under
LUSC	Lung squamous cell carcinoma	51	501	0.552	0.093	-0.714	0.00737	Under
OV	Ovarian serous cystadenocarcinoma	0	307	NA	-1.44	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	-1.191	-0.955	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	-0.924	-0.319	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	1.527	0.791	-0.85	0.00013	Under
READ	Rectum adenocarcinoma	10	167	-0.429	-2.714	-1.998	0.000664	Under
SARC	Sarcoma	2	263	-2.082	0.232	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	-0.359	-0.069	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	0.629	0.177	-0.887	0.011	Under
TGCT	Testicular Germ Cell Tumors	0	156	NA	-0.224	NA	NA	NA
THCA	Thyroid carcinoma	59	509	2.003	0.514	-1.359	1.31e-14	Under
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	0.526	-1.159	-1.974	1.48e-08	Under

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

Tissue	Expression Level (TPM)
Adipose tissue	2.2
Adrenal gland	3.2
Appendix	1.4
Bone marrow	0.1
Breast	2
Cerebral cortex	5.6
Cervix, uterine	5.6
Colon	1
Duodenum	0.4
Endometrium	9.6
Epididymis	2.6
Esophagus	2
Fallopian tube	4
Gallbladder	4
Heart muscle	0.9
Kidney	1.1
Liver	0.1
Lung	3.1
Lymph node	0.6
Ovary	7.7
Pancreas	0.3
Parathyroid gland	29.4
Placenta	3
Prostate	7.6
Rectum	1.2
Salivary gland	0.3
Seminal vesicle	6.8
Skeletal muscle	3.9
Skin	1
Small intestine	0.7
Smooth muscle	7.3
Spleen	0.5
Stomach	0.9
Testis	5.5
Thyroid gland	12
Tonsil	0.5
Urinary bladder	2.2

> Text Mining based Expression

PMID	Expression	Cancer	Evidence
20514431	Overexpression	Villous Adenoma	Genes involved in canonical Wnt (beta-catenin) signaling with increased expression in villous adenomas included wnt1, fz2, csnk2A2, pygo2, pygo1, frat2 and myc, the latter confirmed by qRT-PCR and IHC.

Summary
Symbol	PYGO1
Name	pygopus family PHD finger 1
Aliases	pygopus homolog 1 (Drosophila); pygopus-like protein 1; Pygopus homolog 1
Location	15q21.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	-0.006	0.909	35.9	54.7	9.4	Loss
BRCA	Breast invasive carcinoma	1075	0.044	0.152	32.7	59.3	8	Neutral
CESC	Cervical and endocervical cancers	292	0.05	0.39	21.6	61.6	16.8	Neutral
ESCA	Esophageal carcinoma	183	-0.073	0.326	30.6	50.8	18.6	Neutral
GBM	Glioblastoma multiforme	147	0.314	0.000105	24.5	69.4	6.1	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.077	0.0826	22.2	62.5	15.4	Neutral
KIRC	Kidney renal clear cell carcinoma	525	-0.091	0.0378	6.9	88.6	4.6	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	-0.183	0.0018	11.1	87.2	1.7	Neutral
LAML	Acute Myeloid Leukemia	166	0.001	0.994	2.4	97.6	0	Neutral
LGG	Brain Lower Grade Glioma	513	0.157	0.000352	12.7	85.4	1.9	Neutral
LUAD	Lung adenocarcinoma	512	0.078	0.0766	48	43.9	8	Loss
LUSC	Lung squamous cell carcinoma	498	0.19	1.96e-05	29.5	46.4	24.1	Neutral
OV	Ovarian serous cystadenocarcinoma	300	-0.045	0.44	54.3	38.7	7	Loss
PAAD	Pancreatic adenocarcinoma	177	0.089	0.24	17.5	73.4	9	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.036	0.648	2.5	89.5	8	Neutral
PRAD	Prostate adenocarcinoma	491	0.176	8.43e-05	11.2	88.2	0.6	Neutral
READ	Rectum adenocarcinoma	164	0.241	0.00186	47	49.4	3.7	Loss
SARC	Sarcoma	255	0.198	0.0015	20	53.3	26.7	Neutral
SKCM	Skin Cutaneous Melanoma	367	0.089	0.0904	19.3	57.8	22.9	Neutral
STAD	Stomach adenocarcinoma	413	0.06	0.227	23.7	68.3	8	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.09	0.271	22	43.3	34.7	Gain
THCA	Thyroid carcinoma	497	0.028	0.533	1.6	98.4	0	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	-0.035	0.421	25.7	73	1.3	Neutral

Summary
Symbol	PYGO1
Name	pygopus family PHD finger 1
Aliases	pygopus homolog 1 (Drosophila); pygopus-like protein 1; Pygopus homolog 1
Location	15q21.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.505	0	17	408	0.12	1.89e-06	NS/NA
BRCA	Breast invasive carcinoma	-0.336	0	83	785	0.103	6.2e-97	NS/NA
CESC	Cervical and endocervical cancers	-0.502	0	3	306	NA	NA	NS/NA
ESCA	Esophageal carcinoma	-0.553	0	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.048	0.706	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.447	0	20	522	0.038	3.1e-57	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.406	2.08e-15	24	319	0.167	1.2e-33	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.211	0.000249	23	275	0.149	1.01e-15	NS/NA
LAML	Acute Myeloid Leukemia	-0.165	0.0317	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	0.046	0.293	0	530	NA	NA	NS/NA
LUAD	Lung adenocarcinoma	-0.422	0	21	456	0.009	4.13e-05	NS/NA
LUSC	Lung squamous cell carcinoma	-0.445	0	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.783	0.0172	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.335	4e-06	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.204	0.00519	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.319	6.59e-14	35	498	0.003	1.31e-05	NS/NA
READ	Rectum adenocarcinoma	-0.189	0.0589	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.262	1.86e-05	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.428	0	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.617	0	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.243	0.00228	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.089	0.0356	50	509	0.006	0.0834	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.387	0	34	431	-0.013	0.00144	NS/NA

Summary
Symbol	PYGO1
Name	pygopus family PHD finger 1
Aliases	pygopus homolog 1 (Drosophila); pygopus-like protein 1; Pygopus homolog 1
Location	15q21.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA) [ TOP ]
There is no antibody staining data.

Summary
Symbol	PYGO1
Name	pygopus family PHD finger 1
Aliases	pygopus homolog 1 (Drosophila); pygopus-like protein 1; Pygopus homolog 1
Location	15q21.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.0565	NS	24476821
BRCA	Breast invasive carcinoma	521	0.0037	Significant	23000897
GBM	Glioblastoma multiforme	157	0.052	NS	26824661
HNSC	Head and Neck squamous cell carcinoma	279	1.19e-15	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.00155	Significant	26536169
LGG	Brain Lower Grade Glioma	513	0.000529	Significant	26824661
LUAD	Lung adenocarcinoma	230	0.172	NS	25079552
LUSC	Lung squamous cell carcinoma	178	5.22e-07	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	2.07e-11	Significant	21720365
PRAD	Prostate adenocarcinoma	333	0.000352	Significant	26544944
READ	Rectum adenocarcinoma	67	0.0498	Significant	22810696
SKCM	Skin Cutaneous Melanoma	315	0.0564	NS	26091043
STAD	Stomach adenocarcinoma	277	1.51e-10	Significant	25079317
THCA	Thyroid carcinoma	391	6.13e-05	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.546	NS	23636398

> Overall survival

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	1.541	0.0412	Shorter
BRCA	Breast invasive carcinoma	1079	0.911	0.684	NS
CESC	Cervical and endocervical cancers	291	1.545	0.206	NS
ESCA	Esophageal carcinoma	184	1.063	0.854	NS
GBM	Glioblastoma multiforme	158	0.672	0.118	NS
HNSC	Head and Neck squamous cell carcinoma	518	1.302	0.175	NS
KIRC	Kidney renal clear cell carcinoma	531	1.268	0.263	NS
KIRP	Kidney renal papillary cell carcinoma	287	1.861	0.118	NS
LAML	Acute Myeloid Leukemia	149	0.709	0.226	NS
LGG	Brain Lower Grade Glioma	511	0.763	0.296	NS
LUAD	Lung adenocarcinoma	502	1.183	0.436	NS
LUSC	Lung squamous cell carcinoma	494	1.094	0.635	NS
OV	Ovarian serous cystadenocarcinoma	303	1.322	0.188	NS
PAAD	Pancreatic adenocarcinoma	177	1.647	0.093	NS
PCPG	Pheochromocytoma and Paraganglioma	179	571575217.294	0.0896	NS
PRAD	Prostate adenocarcinoma	497	0.741	0.738	NS
READ	Rectum adenocarcinoma	159	1.332	0.625	NS
SARC	Sarcoma	259	1.646	0.0822	NS
SKCM	Skin Cutaneous Melanoma	459	0.829	0.313	NS
STAD	Stomach adenocarcinoma	388	2.092	0.00145	Shorter
TGCT	Testicular Germ Cell Tumors	134	0	0.161	NS
THCA	Thyroid carcinoma	500	1.27	0.722	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	1.551	0.154	NS

> Stage

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	0.131	0.00824	Higher
BRCA	Breast invasive carcinoma	1071	-0.067	0.0283	Lower
CESC	Cervical and endocervical cancers	167	0.028	0.715	NS
ESCA	Esophageal carcinoma	162	0.064	0.416	NS
HNSC	Head and Neck squamous cell carcinoma	448	0.077	0.102	NS
KIRC	Kidney renal clear cell carcinoma	531	0.028	0.516	NS
KIRP	Kidney renal papillary cell carcinoma	260	0.241	8.88e-05	Higher
LUAD	Lung adenocarcinoma	507	0.083	0.0625	NS
LUSC	Lung squamous cell carcinoma	497	-0.04	0.368	NS
OV	Ovarian serous cystadenocarcinoma	302	-0.052	0.367	NS
PAAD	Pancreatic adenocarcinoma	176	0.064	0.396	NS
READ	Rectum adenocarcinoma	156	0.136	0.0913	NS
SKCM	Skin Cutaneous Melanoma	410	0.036	0.465	NS
STAD	Stomach adenocarcinoma	392	0.126	0.0126	Higher
TGCT	Testicular Germ Cell Tumors	81	-0.039	0.731	NS
THCA	Thyroid carcinoma	499	-0.053	0.241	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	-0.014	0.759	NS

> Grade

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	-0.09	0.14	NS
HNSC	Head and Neck squamous cell carcinoma	498	0.127	0.00448	Higher
KIRC	Kidney renal clear cell carcinoma	525	0.1	0.0216	Higher
LGG	Brain Lower Grade Glioma	514	0.01	0.813	NS
OV	Ovarian serous cystadenocarcinoma	296	-0.076	0.194	NS
PAAD	Pancreatic adenocarcinoma	176	0.045	0.555	NS
STAD	Stomach adenocarcinoma	406	0.166	0.000784	Higher
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.072	0.0981	NS

Summary
Symbol	PYGO1
Name	pygopus family PHD finger 1
Aliases	pygopus homolog 1 (Drosophila); pygopus-like protein 1; Pygopus homolog 1
Location	15q21.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	PYGO1
Name	pygopus family PHD finger 1
Aliases	pygopus homolog 1 (Drosophila); pygopus-like protein 1; Pygopus homolog 1
Location	15q21.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for PYGO1.

Summary
Symbol	PYGO1
Name	pygopus family PHD finger 1
Aliases	pygopus homolog 1 (Drosophila); pygopus-like protein 1; Pygopus homolog 1
Location	15q21.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining [ TOP ]
There is no record for PYGO1.