CR2Cancer

Summary
Symbol	RAG2
Name	recombination activating 2
Aliases	RAG-2; V(D)J recombination-activating protein 2
Location	11p13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

[ TOP ]

Domain

PF03089 Recombination activating protein 2
PF13341 RAG2 PHD domain

Function

Core component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T-lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. DNA cleavage by the RAG complex occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends. The chromatin structure plays an essential role in the V(D)J recombination reactions and the presence of histone H3 trimethylated at 'Lys-4' (H3K4me3) stimulates both the nicking and haipinning steps. The RAG complex also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. The introduction of DNA breaks by the RAG complex on one immunoglobulin allele induces ATM-dependent repositioning of the other allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. In the RAG complex, RAG2 is not the catalytic component but is required for all known catalytic activities mediated by RAG1. It probably acts as a sensor of chromatin state that recruits the RAG complex to H3K4me3 (By similarity).

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification read	#	H3K4me3	#	21423274

> Gene Ontology [ TOP ]
Biological Process	GO:0002200 somatic diversification of immune receptors GO:0002326 B cell lineage commitment GO:0002327 immature B cell differentiation GO:0002329 pre-B cell differentiation GO:0002331 pre-B cell allelic exclusion GO:0002358 B cell homeostatic proliferation GO:0002360 T cell lineage commitment GO:0002521 leukocyte differentiation GO:0002562 somatic diversification of immune receptors via germline recombination within a single locus GO:0006310 DNA recombination GO:0007159 leukocyte cell-cell adhesion GO:0016444 somatic cell DNA recombination GO:0030098 lymphocyte differentiation GO:0030183 B cell differentiation GO:0030217 T cell differentiation GO:0032943 mononuclear cell proliferation GO:0033077 T cell differentiation in thymus GO:0033151 V(D)J recombination GO:0035265 organ growth GO:0042100 B cell proliferation GO:0042110 T cell activation GO:0042113 B cell activation GO:0045165 cell fate commitment GO:0045927 positive regulation of growth GO:0046620 regulation of organ growth GO:0046622 positive regulation of organ growth GO:0046651 lymphocyte proliferation GO:0048638 regulation of developmental growth GO:0048639 positive regulation of developmental growth GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0070661 leukocyte proliferation GO:0071593 lymphocyte aggregation GO:0071594 thymocyte aggregation
Molecular Function	GO:0003682 chromatin binding GO:0004842 ubiquitin-protein transferase activity GO:0005543 phospholipid binding GO:0005546 phosphatidylinositol-4,5-bisphosphate binding GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding GO:0019787 ubiquitin-like protein transferase activity GO:0035064 methylated histone binding GO:0035091 phosphatidylinositol binding GO:0042393 histone binding GO:0043168 anion binding GO:0043325 phosphatidylinositol-3,4-bisphosphate binding GO:0061630 ubiquitin protein ligase activity GO:0061659 ubiquitin-like protein ligase activity GO:0080025 phosphatidylinositol-3,5-bisphosphate binding GO:1901981 phosphatidylinositol phosphate binding GO:1902936 phosphatidylinositol bisphosphate binding
Cellular Component	-

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04068 FoxO signaling pathway
Reactome	R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-168256: Immune System R-HSA-1266695: Interleukin-7 signaling R-HSA-5683057: MAPK family signaling cascades R-HSA-5687128: MAPK6/MAPK4 signaling R-HSA-162582: Signal Transduction R-HSA-449147: Signaling by Interleukins

Summary
Symbol	RAG2
Name	recombination activating 2
Aliases	RAG-2; V(D)J recombination-activating protein 2
Location	11p13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM212301	c.475C>A	p.R159S	Substitution - Missense	Breast
COSM3869125	c.1271A>T	p.D424V	Substitution - Missense	Skin
COSM5414034	c.385T>C	p.L129L	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM926750	c.1236G>T	p.E412D	Substitution - Missense	Endometrium
COSM4930854	c.804T>C	p.N268N	Substitution - coding silent	Liver
COSM1978308	c.1517G>A	p.R506H	Substitution - Missense	Large_intestine
COSM3447093	c.661G>A	p.G221R	Substitution - Missense	Skin
COSM5372423	c.1483C>T	p.L495L	Substitution - coding silent	Skin
COSM926763	c.339T>C	p.V113V	Substitution - coding silent	Endometrium
COSM4799861	c.99A>G	p.Q33Q	Substitution - coding silent	Liver
COSM386383	c.1547C>G	p.P516R	Substitution - Missense	Lung
COSM3447100	c.284G>A	p.G95E	Substitution - Missense	Skin
COSM3986140	c.823G>A	p.G275S	Substitution - Missense	Kidney
COSM1717716	c.1320A>C	p.K440N	Substitution - Missense	Adrenal_gland
COSM337257	c.306G>C	p.E102D	Substitution - Missense	Lung
COSM1978335	c.619C>T	p.H207Y	Substitution - Missense	Skin
COSM428957	c.1082C>T	p.T361I	Substitution - Missense	Breast
COSM236844	c.245G>T	p.G82V	Substitution - Missense	Prostate
COSM4795530	c.401C>T	p.P134L	Substitution - Missense	Liver
COSM328290	c.22G>A	p.V8I	Substitution - Missense	Pancreas
COSM4551040	c.516G>A	p.W172*	Substitution - Nonsense	Skin
COSM3447085	c.1463T>C	p.L488P	Substitution - Missense	Skin
COSM926756	c.870C>T	p.I290I	Substitution - coding silent	Endometrium
COSM926759	c.475C>T	p.R159C	Substitution - Missense	Endometrium
COSM4574353	c.357G>T	p.K119N	Substitution - Missense	Bone
COSM5793894	c.1378G>A	p.D460N	Substitution - Missense	Breast
COSM108530	c.418C>T	p.H140Y	Substitution - Missense	Skin
COSM396851	c.1415G>A	p.G472E	Substitution - Missense	Skin
COSM1745202	c.724delC	p.L242fs*6	Deletion - Frameshift	Urinary_tract
COSM314668	c.1496delA	p.K499fs*4	Deletion - Frameshift	Stomach
COSM3447092	c.877G>A	p.E293K	Substitution - Missense	Skin
COSM5448165	c.1257C>T	p.C419C	Substitution - coding silent	Large_intestine
COSM106672	c.968G>A	p.G323E	Substitution - Missense	Skin
COSM687405	c.1438G>C	p.E480Q	Substitution - Missense	Lung
COSM5626039	c.80A>G	p.Q27R	Substitution - Missense	Oesophagus
COSM314668	c.1496delA	p.K499fs*4	Deletion - Frameshift	Soft_tissue
COSM3869124	c.1506G>A	p.M502I	Substitution - Missense	Skin
COSM322975	c.452G>A	p.S151N	Substitution - Missense	Lung
COSM3732541	c.1281C>A	p.I427I	Substitution - coding silent	Stomach
COSM4795530	c.401C>T	p.P134L	Substitution - Missense	Liver
COSM340029	c.1348G>C	p.D450H	Substitution - Missense	Lung
COSM926749	c.1307C>G	p.T436S	Substitution - Missense	Endometrium
COSM4720041	c.1524delA	p.G509fs*6	Deletion - Frameshift	Large_intestine
COSM5817926	c.14T>G	p.M5R	Substitution - Missense	Liver
COSM4798874	c.1331T>A	p.I444N	Substitution - Missense	Liver
COSM314670	c.1201A>G	p.T401A	Substitution - Missense	Lung
COSM1240001	c.1105A>G	p.T369A	Substitution - Missense	Liver
COSM5925630	c.614C>T	p.S205F	Substitution - Missense	Skin
COSM5623773	c.30T>C	p.N10N	Substitution - coding silent	Oesophagus
COSM4752833	c.1480G>T	p.V494F	Substitution - Missense	Stomach
COSM4957048	c.507A>T	p.T169T	Substitution - coding silent	Liver
COSM4956258	c.901G>A	p.E301K	Substitution - Missense	Liver
COSM386384	c.879G>T	p.E293D	Substitution - Missense	Lung
COSM84061	c.814G>T	p.V272F	Substitution - Missense	Pancreas
COSM2149450	c.820G>T	p.V274F	Substitution - Missense	Central_nervous_system
COSM5691776	c.385T>A	p.L129M	Substitution - Missense	Soft_tissue
COSM5006972	c.756G>C	p.L252F	Substitution - Missense	Large_intestine
COSM3447097	c.447G>A	p.G149G	Substitution - coding silent	Skin
COSM4032632	c.153G>A	p.K51K	Substitution - coding silent	Stomach
COSM1978339	c.513_514insA	p.W172fs*3	Insertion - Frameshift	Large_intestine
COSM1492529	c.1154G>A	p.C385Y	Substitution - Missense	Kidney
COSM1263753	c.1110A>C	p.E370D	Substitution - Missense	Oesophagus
COSM3415832	c.418C>A	p.H140N	Substitution - Missense	Large_intestine
COSM4551040	c.516G>A	p.W172*	Substitution - Nonsense	Skin
COSM4145680	c.221A>C	p.Y74S	Substitution - Missense	Thyroid
COSM1263749	c.1011A>G	p.Q337Q	Substitution - coding silent	Oesophagus
COSM3787047	c.688C>G	p.P230A	Substitution - Missense	Pancreas
COSM106672	c.968G>A	p.G323E	Substitution - Missense	Skin
COSM1978344	c.356A>G	p.K119R	Substitution - Missense	Liver
COSM3447097	c.447G>A	p.G149G	Substitution - coding silent	Skin
COSM338958	c.581C>A	p.S194*	Substitution - Nonsense	Lung
COSM926755	c.1035C>A	p.F345L	Substitution - Missense	Endometrium
COSM4507706	c.753C>T	p.V251V	Substitution - coding silent	Skin
COSM926758	c.589C>A	p.L197I	Substitution - Missense	Endometrium
COSM1627962	c.888G>T	p.K296N	Substitution - Missense	Liver
COSM1289551	c.3G>A	p.M1I	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1298011	c.1512C>A	p.S504S	Substitution - coding silent	Urinary_tract
COSM5793894	c.1378G>A	p.D460N	Substitution - Missense	Breast
COSM3979607	c.48G>T	p.Q16H	Substitution - Missense	Lung
COSM4901442	c.1554G>A	p.K518K	Substitution - coding silent	Skin
COSM5372424	c.956G>A	p.G319E	Substitution - Missense	Skin
COSM1135175	c.774C>T	p.V258V	Substitution - coding silent	Kidney
COSM1263754	c.1516C>T	p.R506C	Substitution - Missense	Oesophagus
COSM4600925	c.950G>A	p.W317*	Substitution - Nonsense	Upper_aerodigestive_tract
COSM4752835	c.1132T>C	p.F378L	Substitution - Missense	Stomach
COSM1240001	c.1105A>G	p.T369A	Substitution - Missense	Oesophagus
COSM4188956	c.1433G>T	p.C478F	Substitution - Missense	Kidney
COSM314668	c.1496delA	p.K499fs*4	Deletion - Frameshift	Lung
COSM4563308	c.967G>A	p.G323R	Substitution - Missense	Skin
COSM1298012	c.259G>C	p.E87Q	Substitution - Missense	Urinary_tract
COSM5816691	c.678T>A	p.N226K	Substitution - Missense	Liver
COSM1675949	c.704G>T	p.R235I	Substitution - Missense	Large_intestine
COSM314669	c.1246T>A	p.W416R	Substitution - Missense	Lung
COSM1675948	c.1221A>C	p.E407D	Substitution - Missense	Central_nervous_system
COSM4032628	c.1235A>G	p.E412G	Substitution - Missense	Stomach
COSM3447084	c.1478G>A	p.R493K	Substitution - Missense	Skin
COSM1263751	c.1374C>T	p.C458C	Substitution - coding silent	Oesophagus
COSM3447092	c.877G>A	p.E293K	Substitution - Missense	Skin
COSM1978315	c.1348G>A	p.D450N	Substitution - Missense	Skin
COSM687404	c.1163C>G	p.A388G	Substitution - Missense	Lung
COSM5050793	c.1325C>T	p.A442V	Substitution - Missense	Stomach
COSM5937510	c.280C>T	p.H94Y	Substitution - Missense	Skin
COSM4432437	c.728G>A	p.G243D	Substitution - Missense	Oesophagus
COSM3383451	c.1536A>C	p.K512N	Substitution - Missense	Pancreas
COSM5372422	c.1511C>T	p.S504F	Substitution - Missense	Skin
COSM1675949	c.704G>T	p.R235I	Substitution - Missense	Large_intestine
COSM4434568	c.726G>T	p.L242L	Substitution - coding silent	Oesophagus
COSM1703820	c.865A>G	p.I289V	Substitution - Missense	Skin
COSM3397661	c.268C>G	p.Q90E	Substitution - Missense	Central_nervous_system
COSM358524	c.1446G>T	p.V482V	Substitution - coding silent	Lung
COSM1240001	c.1105A>G	p.T369A	Substitution - Missense	Liver
COSM4032631	c.535C>A	p.L179M	Substitution - Missense	Stomach
COSM5554293	c.185T>C	p.F62S	Substitution - Missense	Prostate
COSM5809880	c.675C>T	p.A225A	Substitution - coding silent	Liver
COSM3869124	c.1506G>A	p.M502I	Substitution - Missense	Skin
COSM5810364	c.1000G>A	p.D334N	Substitution - Missense	Liver
COSM1686157	c.898C>T	p.R300C	Substitution - Missense	Skin
COSM3356185	c.871T>A	p.S291T	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5607591	c.704G>A	p.R235K	Substitution - Missense	Skin
COSM926752	c.1163C>T	p.A388V	Substitution - Missense	Endometrium
COSM3447090	c.1260C>T	p.C420C	Substitution - coding silent	Skin
COSM5689710	c.17T>A	p.V6E	Substitution - Missense	Soft_tissue
COSM4484341	c.279C>T	p.I93I	Substitution - coding silent	Skin
COSM926759	c.475C>T	p.R159C	Substitution - Missense	Endometrium
COSM428958	c.217C>T	p.R73C	Substitution - Missense	Breast
COSM5050794	c.944A>C	p.K315T	Substitution - Missense	Stomach
COSM4519724	c.1024G>A	p.G342R	Substitution - Missense	Skin
COSM1978353	c.105C>T	p.G35G	Substitution - coding silent	Large_intestine
COSM3447097	c.447G>A	p.G149G	Substitution - coding silent	Skin
COSM5500499	c.923C>A	p.T308N	Substitution - Missense	Biliary_tract
COSM396851	c.1415G>A	p.G472E	Substitution - Missense	Lung
COSM3447094	c.601C>T	p.Q201*	Substitution - Nonsense	Skin
COSM361563	c.349A>G	p.N117D	Substitution - Missense	Lung
COSM5810348	c.1001A>T	p.D334V	Substitution - Missense	Liver
COSM314668	c.1496delA	p.K499fs*4	Deletion - Frameshift	Stomach
COSM4563308	c.967G>A	p.G323R	Substitution - Missense	Skin
COSM3931305	c.509A>C	p.E170A	Substitution - Missense	Urinary_tract
COSM4798874	c.1331T>A	p.I444N	Substitution - Missense	Liver
COSM1686157	c.898C>T	p.R300C	Substitution - Missense	Skin
COSM1263750	c.231T>C	p.T77T	Substitution - coding silent	Oesophagus
COSM1720211	c.1118G>A	p.G373E	Substitution - Missense	Skin
COSM3397660	c.1381C>A	p.L461M	Substitution - Missense	Central_nervous_system
COSM4957048	c.507A>T	p.T169T	Substitution - coding silent	Liver
COSM3447099	c.288G>A	p.G96G	Substitution - coding silent	Skin
COSM5772222	c.767T>A	p.I256N	Substitution - Missense	Breast
COSM4956258	c.901G>A	p.E301K	Substitution - Missense	Liver
COSM926760	c.463C>A	p.L155I	Substitution - Missense	Endometrium
COSM84061	c.814G>T	p.V272F	Substitution - Missense	Pancreas
COSM1263752	c.24C>T	p.V8V	Substitution - coding silent	Oesophagus
COSM3447088	c.1340C>T	p.S447F	Substitution - Missense	Skin
COSM1160983	c.628A>G	p.I210V	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM322974	c.1276G>T	p.D426Y	Substitution - Missense	Lung
COSM4396732	c.1471C>T	p.P491S	Substitution - Missense	Skin
COSM3447089	c.1278T>C	p.D426D	Substitution - coding silent	Skin
COSM5613357	c.1064C>A	p.T355N	Substitution - Missense	Lung
COSM926752	c.1163C>T	p.A388V	Substitution - Missense	Endometrium
COSM687401	c.286G>T	p.G96W	Substitution - Missense	Lung
COSM5483566	c.146A>C	p.D49A	Substitution - Missense	Large_intestine
COSM1978343	c.367C>T	p.R123C	Substitution - Missense	Upper_aerodigestive_tract
COSM1703819	c.1120G>A	p.D374N	Substitution - Missense	Skin
COSM4391895	c.492T>C	p.S164S	Substitution - coding silent	Prostate
COSM3869124	c.1506G>A	p.M502I	Substitution - Missense	Skin
COSM926754	c.1049G>A	p.C350Y	Substitution - Missense	Endometrium
COSM1978316	c.1329G>A	p.M443I	Substitution - Missense	Skin
COSM4920847	c.1260C>A	p.C420*	Substitution - Nonsense	Liver
COSM926751	c.1196T>G	p.F399C	Substitution - Missense	Endometrium
COSM1675949	c.704G>T	p.R235I	Substitution - Missense	Large_intestine
COSM1223039	c.443G>A	p.R148Q	Substitution - Missense	Large_intestine
COSM3979605	c.1502C>A	p.P501Q	Substitution - Missense	Lung
COSM3447091	c.892G>A	p.E298K	Substitution - Missense	Skin
COSM5372422	c.1511C>T	p.S504F	Substitution - Missense	Skin
COSM1720211	c.1118G>A	p.G373E	Substitution - Missense	Skin
COSM4720042	c.473G>A	p.G158E	Substitution - Missense	Large_intestine
COSM3979606	c.99A>T	p.Q33H	Substitution - Missense	Lung
COSM5922927	c.880G>A	p.D294N	Substitution - Missense	Skin
COSM3791466	c.1044G>C	p.L348F	Substitution - Missense	Cervix
COSM1353725	c.589C>T	p.L197F	Substitution - Missense	Large_intestine
COSM4752834	c.1388A>G	p.E463G	Substitution - Missense	Stomach
COSM3729513	c.67A>G	p.N23D	Substitution - Missense	Stomach
COSM365624	c.1335C>A	p.Y445*	Substitution - Nonsense	Lung
COSM106672	c.968G>A	p.G323E	Substitution - Missense	Skin
COSM687400	c.145G>C	p.D49H	Substitution - Missense	Lung
COSM3869124	c.1506G>A	p.M502I	Substitution - Missense	Skin
COSM1353724	c.1029C>A	p.F343L	Substitution - Missense	Large_intestine
COSM3869126	c.962A>G	p.N321S	Substitution - Missense	Skin
COSM1171779	c.406G>T	p.A136S	Substitution - Missense	Oesophagus
COSM78389	c.1153T>C	p.C385R	Substitution - Missense	Ovary
COSM926761	c.449A>G	p.K150R	Substitution - Missense	Endometrium
COSM1683446	c.508_509insA	p.W172fs*3	Insertion - Frameshift	Large_intestine
COSM314669	c.1246T>A	p.W416R	Substitution - Missense	Soft_tissue
COSM1978335	c.619C>T	p.H207Y	Substitution - Missense	Skin
COSM3447093	c.661G>A	p.G221R	Substitution - Missense	Skin
COSM380825	c.1485A>T	p.L495L	Substitution - coding silent	Lung
COSM3447098	c.446G>A	p.G149E	Substitution - Missense	Skin
COSM1703819	c.1120G>A	p.D374N	Substitution - Missense	Skin
COSM1978311	c.1429T>A	p.Y477N	Substitution - Missense	Large_intestine
COSM106324	c.684C>T	p.I228I	Substitution - coding silent	Skin
COSM4413071	c.882C>A	p.D294E	Substitution - Missense	Oesophagus
COSM4799861	c.99A>G	p.Q33Q	Substitution - coding silent	Liver
COSM3791466	c.1044G>C	p.L348F	Substitution - Missense	Urinary_tract
COSM314668	c.1496delA	p.K499fs*4	Deletion - Frameshift	Large_intestine
COSM1978343	c.367C>T	p.R123C	Substitution - Missense	Skin
COSM2149450	c.820G>T	p.V274F	Substitution - Missense	Central_nervous_system
COSM106672	c.968G>A	p.G323E	Substitution - Missense	Skin
COSM926757	c.812T>G	p.F271C	Substitution - Missense	Endometrium
COSM1223039	c.443G>A	p.R148Q	Substitution - Missense	Soft_tissue
COSM3967484	c.1473C>T	p.P491P	Substitution - coding silent	Central_nervous_system
COSM926748	c.1524A>G	p.K508K	Substitution - coding silent	Endometrium
COSM926753	c.1163C>A	p.A388E	Substitution - Missense	Endometrium
COSM4032630	c.841A>C	p.N281H	Substitution - Missense	Stomach
COSM3447103	c.153G>T	p.K51N	Substitution - Missense	Skin
COSM926762	c.362C>A	p.T121N	Substitution - Missense	Endometrium
COSM379565	c.342C>G	p.C114W	Substitution - Missense	Lung
COSM4032629	c.986T>G	p.L329R	Substitution - Missense	Stomach
COSM5372421	c.1560C>T	p.S520S	Substitution - coding silent	Skin

> Text Mining based Variations [ TOP ]
There is no record for RAG2.

Summary
Symbol	RAG2
Name	recombination activating 2
Aliases	RAG-2; V(D)J recombination-activating protein 2
Location	11p13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM) [ TOP ]
There is no PTM data

Summary
Symbol	RAG2
Name	recombination activating 2
Aliases	RAG-2; V(D)J recombination-activating protein 2
Location	11p13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
LAML	Acute Myeloid Leukemia	0	173	NA	-4.99	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	-6.209	-2.688	NA	NA	NA
THCA	Thyroid carcinoma	59	509	2.652	-5.356	-6.28	1.02e-31	Under
THYM	Thymoma	2	120	7.305	6.138	NA	NA	NA

> Cancer Cell Line Encyclopedia (CCLE)

[ TOP ]

Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	3.5
Autonomic ganglia	CHP212	3.4
Autonomic ganglia	IMR32	3.6
Autonomic ganglia	KELLY	3.3
Autonomic ganglia	KPNRTBM1	3.4
Autonomic ganglia	KPNSI9S	3.5
Autonomic ganglia	KPNYN	3.5
Autonomic ganglia	MHHNB11	3.6
Autonomic ganglia	NB1	3.5
Autonomic ganglia	NH6	3.5
Autonomic ganglia	SHSY5Y	4.4
Autonomic ganglia	SIMA	3.4
Autonomic ganglia	SKNAS	3.8
Autonomic ganglia	SKNBE2	4
Autonomic ganglia	SKNDZ	3.7
Autonomic ganglia	SKNFI	3.4
Autonomic ganglia	SKNSH	3.6
Biliary tract	HUCCT1	3.6
Biliary tract	HUH28	3.5
Biliary tract	SNU1079	3.8
Biliary tract	SNU1196	3.7
Biliary tract	SNU245	3.7
Biliary tract	SNU308	4.2
Biliary tract	SNU478	3.7
Bone	143B	3.4
Bone	A673	3.6
Bone	CADOES1	3.5
Bone	CAL78	3.4
Bone	G292CLONEA141B1	3.6
Bone	HOS	3.4
Bone	HS706T	3.7
Bone	HS737T	3.4
Bone	HS819T	3.6
Bone	HS821T	3.7
Bone	HS822T	3.5
Bone	HS863T	3.6
Bone	HS870T	3.8
Bone	HS888T	3.4
Bone	MG63	3.7
Bone	MHHES1	3.4
Bone	OUMS27	3.5
Bone	RDES	3.7
Bone	SJSA1	3.7
Bone	SKES1	3.7
Bone	SKNMC	3.6
Bone	SW1353	3.3
Bone	T173	3.5
Bone	TC71	3.7
Bone	U2OS	3.6
Breast	AU565	3.5
Breast	BT20	3.6
Breast	BT474	3.6
Breast	BT483	3.4
Breast	BT549	3.8
Breast	CAL120	3.6
Breast	CAL148	3.4
Breast	CAL51	3.3
Breast	CAL851	3.5
Breast	CAMA1	3.7
Breast	DU4475	3.7
Breast	EFM192A	3.6
Breast	EFM19	3.6
Breast	EVSAT	3.9
Breast	HCC1143	3.4
Breast	HCC1187	3.6
Breast	HCC1395	3.5
Breast	HCC1419	3.5
Breast	HCC1428	3.6
Breast	HCC1500	3.4
Breast	HCC1569	3.5
Breast	HCC1599	3.5
Breast	HCC1806	3.5
Breast	HCC1937	3.4
Breast	HCC1954	3.5
Breast	HCC202	3.9
Breast	HCC2157	3.6
Breast	HCC2218	3.3
Breast	HCC38	3.3
Breast	HCC70	3.6
Breast	HDQP1	3.5
Breast	HMC18	3.8
Breast	HS274T	3.5
Breast	HS281T	3.3
Breast	HS343T	3.6
Breast	HS578T	3.8
Breast	HS606T	3.5
Breast	HS739T	3.4
Breast	HS742T	3.5
Breast	JIMT1	3.5
Breast	KPL1	3.4
Breast	MCF7	3.5
Breast	MDAMB134VI	3.7
Breast	MDAMB157	3.3
Breast	MDAMB175VII	3.5
Breast	MDAMB231	3.4
Breast	MDAMB361	3.4
Breast	MDAMB415	3.4
Breast	MDAMB436	3.6
Breast	MDAMB453	3.5
Breast	MDAMB468	3.7
Breast	SKBR3	3.6
Breast	T47D	3.5
Breast	UACC812	3.6
Breast	UACC893	3.5
Breast	YMB1	3.4
Breast	ZR751	3.6
Breast	ZR7530	3.4
Central nervous system	1321N1	3.4
Central nervous system	42MGBA	3.4
Central nervous system	8MGBA	3.3
Central nervous system	A172	3.4
Central nervous system	AM38	3.6
Central nervous system	BECKER	3.4
Central nervous system	CAS1	3.6
Central nervous system	CCFSTTG1	3.4
Central nervous system	D283MED	3.8
Central nervous system	D341MED	3.7
Central nervous system	DAOY	3.3
Central nervous system	DBTRG05MG	3.5
Central nervous system	DKMG	3.4
Central nervous system	GAMG	3.5
Central nervous system	GB1	3.4
Central nervous system	GI1	3.7
Central nervous system	GMS10	3.5
Central nervous system	GOS3	3.5
Central nervous system	H4	3.5
Central nervous system	HS683	3.4
Central nervous system	KALS1	3.3
Central nervous system	KG1C	3.5
Central nervous system	KNS42	3.4
Central nervous system	KNS60	3.4
Central nervous system	KNS81	3.6
Central nervous system	KS1	3.3
Central nervous system	LN18	3.4
Central nervous system	LN229	3.7
Central nervous system	M059K	3.7
Central nervous system	MOGGCCM	3.6
Central nervous system	MOGGUVW	3.3
Central nervous system	NMCG1	3.3
Central nervous system	ONS76	3.8
Central nervous system	SF126	3.5
Central nervous system	SF295	3.3
Central nervous system	SNB19	3.6
Central nervous system	SNU1105	3.6
Central nervous system	SNU201	3.6
Central nervous system	SNU466	3.7
Central nervous system	SNU489	3.7
Central nervous system	SNU626	3.5
Central nervous system	SNU738	3.5
Central nervous system	SW1088	3.5
Central nervous system	SW1783	3.5
Central nervous system	T98G	3.5
Central nervous system	TM31	3.5
Central nervous system	U118MG	3.7
Central nervous system	U138MG	3.3
Central nervous system	U251MG	3.4
Central nervous system	U87MG	3.5
Central nervous system	YH13	3.6
Central nervous system	YKG1	3.4
Endometrium	AN3CA	3.7
Endometrium	COLO684	3.6
Endometrium	EFE184	3.5
Endometrium	EN	3.8
Endometrium	ESS1	3.4
Endometrium	HEC108	3.4
Endometrium	HEC151	3.8
Endometrium	HEC1A	3.3
Endometrium	HEC1B	3.4
Endometrium	HEC251	3.6
Endometrium	HEC265	3.6
Endometrium	HEC50B	3.7
Endometrium	HEC59	3.7
Endometrium	HEC6	3.6
Endometrium	ISHIKAWAHERAKLIO02ER	3.6
Endometrium	JHUEM1	3.5
Endometrium	JHUEM2	3.4
Endometrium	JHUEM3	3.5
Endometrium	KLE	3.6
Endometrium	MFE280	3.5
Endometrium	MFE296	3.5
Endometrium	MFE319	3.8
Endometrium	RL952	3.6
Endometrium	SNGM	3.5
Endometrium	SNU1077	3.6
Endometrium	SNU685	3.7
Endometrium	TEN	3.5
Haematopoietic and lymphoid	697	8.9
Haematopoietic and lymphoid	A3KAW	3.5
Haematopoietic and lymphoid	A4FUK	3.7
Haematopoietic and lymphoid	ALLSIL	6
Haematopoietic and lymphoid	AML193	3.4
Haematopoietic and lymphoid	AMO1	3.5
Haematopoietic and lymphoid	BCP1	3.6
Haematopoietic and lymphoid	BDCM	3.3
Haematopoietic and lymphoid	BL41	5.9
Haematopoietic and lymphoid	BL70	3.7
Haematopoietic and lymphoid	BV173	4.7
Haematopoietic and lymphoid	CA46	8.8
Haematopoietic and lymphoid	CI1	3.7
Haematopoietic and lymphoid	CMK115	3.5
Haematopoietic and lymphoid	CMK86	3.7
Haematopoietic and lymphoid	CMK	3.9
Haematopoietic and lymphoid	CMLT1	7.3
Haematopoietic and lymphoid	COLO775	3.9
Haematopoietic and lymphoid	DAUDI	4.2
Haematopoietic and lymphoid	DB	3.7
Haematopoietic and lymphoid	DEL	3.6
Haematopoietic and lymphoid	DND41	8.7
Haematopoietic and lymphoid	DOHH2	3.5
Haematopoietic and lymphoid	EB1	3.7
Haematopoietic and lymphoid	EB2	3.5
Haematopoietic and lymphoid	EHEB	3.4
Haematopoietic and lymphoid	EJM	3.6
Haematopoietic and lymphoid	EM2	3.4
Haematopoietic and lymphoid	EOL1	3.6
Haematopoietic and lymphoid	F36P	3.6
Haematopoietic and lymphoid	GA10	5.2
Haematopoietic and lymphoid	GDM1	3.4
Haematopoietic and lymphoid	GRANTA519	3.5
Haematopoietic and lymphoid	HDLM2	3.5
Haematopoietic and lymphoid	HDMYZ	3.4
Haematopoietic and lymphoid	HEL9217	3.2
Haematopoietic and lymphoid	HEL	3.6
Haematopoietic and lymphoid	HH	3.8
Haematopoietic and lymphoid	HL60	3.7
Haematopoietic and lymphoid	HPBALL	7.1
Haematopoietic and lymphoid	HS604T	3.6
Haematopoietic and lymphoid	HS611T	3.3
Haematopoietic and lymphoid	HS616T	3.7
Haematopoietic and lymphoid	HS751T	3.7
Haematopoietic and lymphoid	HT	3.5
Haematopoietic and lymphoid	HTK	3.5
Haematopoietic and lymphoid	HUNS1	3.9
Haematopoietic and lymphoid	HUT102	3.6
Haematopoietic and lymphoid	HUT78	3.6
Haematopoietic and lymphoid	JEKO1	3.6
Haematopoietic and lymphoid	JK1	3.5
Haematopoietic and lymphoid	JM1	6.9
Haematopoietic and lymphoid	JURKAT	8.1
Haematopoietic and lymphoid	JURLMK1	3.3
Haematopoietic and lymphoid	JVM2	3.6
Haematopoietic and lymphoid	JVM3	3.6
Haematopoietic and lymphoid	K562	3.6
Haematopoietic and lymphoid	KARPAS299	3.7
Haematopoietic and lymphoid	KARPAS422	3.6
Haematopoietic and lymphoid	KARPAS620	3.5
Haematopoietic and lymphoid	KASUMI1	3.6
Haematopoietic and lymphoid	KASUMI2	9.4
Haematopoietic and lymphoid	KASUMI6	3.6
Haematopoietic and lymphoid	KCL22	3.5
Haematopoietic and lymphoid	KE37	5.2
Haematopoietic and lymphoid	KE97	3.7
Haematopoietic and lymphoid	KG1	3.6
Haematopoietic and lymphoid	KHM1B	3.3
Haematopoietic and lymphoid	KIJK	3.6
Haematopoietic and lymphoid	KMH2	3.6
Haematopoietic and lymphoid	KMM1	3.6
Haematopoietic and lymphoid	KMS11	3.6
Haematopoietic and lymphoid	KMS12BM	3.7
Haematopoietic and lymphoid	KMS18	3.5
Haematopoietic and lymphoid	KMS20	3.8
Haematopoietic and lymphoid	KMS21BM	3.7
Haematopoietic and lymphoid	KMS26	3.7
Haematopoietic and lymphoid	KMS27	3.5
Haematopoietic and lymphoid	KMS28BM	3.8
Haematopoietic and lymphoid	KMS34	3.5
Haematopoietic and lymphoid	KO52	3.5
Haematopoietic and lymphoid	KOPN8	8.9
Haematopoietic and lymphoid	KU812	3.9
Haematopoietic and lymphoid	KYO1	3.7
Haematopoietic and lymphoid	L1236	3.4
Haematopoietic and lymphoid	L363	3.5
Haematopoietic and lymphoid	L428	3.5
Haematopoietic and lymphoid	L540	3.6
Haematopoietic and lymphoid	LAMA84	4.9
Haematopoietic and lymphoid	LOUCY	4.5
Haematopoietic and lymphoid	LP1	3.4
Haematopoietic and lymphoid	M07E	3.8
Haematopoietic and lymphoid	MC116	3.6
Haematopoietic and lymphoid	ME1	4.7
Haematopoietic and lymphoid	MEC1	3.5
Haematopoietic and lymphoid	MEC2	3.7
Haematopoietic and lymphoid	MEG01	3.7
Haematopoietic and lymphoid	MHHCALL2	8.3
Haematopoietic and lymphoid	MHHCALL3	9
Haematopoietic and lymphoid	MHHCALL4	8.5
Haematopoietic and lymphoid	MINO	3.6
Haematopoietic and lymphoid	MJ	3.7
Haematopoietic and lymphoid	MM1S	3.5
Haematopoietic and lymphoid	MOLM13	3.6
Haematopoietic and lymphoid	MOLM16	3.6
Haematopoietic and lymphoid	MOLM6	3.6
Haematopoietic and lymphoid	MOLP2	3.6
Haematopoietic and lymphoid	MOLP8	3.7
Haematopoietic and lymphoid	MOLT13	5.8
Haematopoietic and lymphoid	MOLT16	3.6
Haematopoietic and lymphoid	MOLT4	8.4
Haematopoietic and lymphoid	MONOMAC1	3.4
Haematopoietic and lymphoid	MONOMAC6	3.5
Haematopoietic and lymphoid	MOTN1	3.4
Haematopoietic and lymphoid	MUTZ5	8.5
Haematopoietic and lymphoid	MV411	3.7
Haematopoietic and lymphoid	NALM19	8.5
Haematopoietic and lymphoid	NALM1	8.3
Haematopoietic and lymphoid	NALM6	9.2
Haematopoietic and lymphoid	NAMALWA	7.8
Haematopoietic and lymphoid	NB4	3.5
Haematopoietic and lymphoid	NCIH929	3.6
Haematopoietic and lymphoid	NCO2	5.2
Haematopoietic and lymphoid	NOMO1	3.3
Haematopoietic and lymphoid	NUDHL1	3.6
Haematopoietic and lymphoid	NUDUL1	8.3
Haematopoietic and lymphoid	OCIAML2	3.7
Haematopoietic and lymphoid	OCIAML3	3.8
Haematopoietic and lymphoid	OCIAML5	3.4
Haematopoietic and lymphoid	OCILY10	3.7
Haematopoietic and lymphoid	OCILY19	8.2
Haematopoietic and lymphoid	OCILY3	3.6
Haematopoietic and lymphoid	OCIM1	3.5
Haematopoietic and lymphoid	OPM2	3.6
Haematopoietic and lymphoid	P12ICHIKAWA	6.6
Haematopoietic and lymphoid	P31FUJ	3.5
Haematopoietic and lymphoid	P3HR1	3.5
Haematopoietic and lymphoid	PCM6	3.9
Haematopoietic and lymphoid	PEER	3.8
Haematopoietic and lymphoid	PF382	6.2
Haematopoietic and lymphoid	PFEIFFER	3.6
Haematopoietic and lymphoid	PL21	3.3
Haematopoietic and lymphoid	RAJI	3.7
Haematopoietic and lymphoid	RCHACV	9.5
Haematopoietic and lymphoid	REC1	3.6
Haematopoietic and lymphoid	REH	10.3
Haematopoietic and lymphoid	RI1	3.7
Haematopoietic and lymphoid	RL	3.6
Haematopoietic and lymphoid	RPMI8226	3.4
Haematopoietic and lymphoid	RPMI8402	3.6
Haematopoietic and lymphoid	RS411	8.6
Haematopoietic and lymphoid	SEM	4
Haematopoietic and lymphoid	SET2	3.5
Haematopoietic and lymphoid	SIGM5	3.6
Haematopoietic and lymphoid	SKM1	3.5
Haematopoietic and lymphoid	SKMM2	3.4
Haematopoietic and lymphoid	SR786	3.4
Haematopoietic and lymphoid	ST486	9
Haematopoietic and lymphoid	SUDHL10	3.9
Haematopoietic and lymphoid	SUDHL1	3.5
Haematopoietic and lymphoid	SUDHL4	3.5
Haematopoietic and lymphoid	SUDHL5	3.6
Haematopoietic and lymphoid	SUDHL6	3.7
Haematopoietic and lymphoid	SUDHL8	10.3
Haematopoietic and lymphoid	SUPB15	7.8
Haematopoietic and lymphoid	SUPHD1	3.7
Haematopoietic and lymphoid	SUPM2	3.6
Haematopoietic and lymphoid	SUPT11	3.6
Haematopoietic and lymphoid	SUPT1	9.1
Haematopoietic and lymphoid	TALL1	3.4
Haematopoietic and lymphoid	TF1	3.6
Haematopoietic and lymphoid	THP1	3.4
Haematopoietic and lymphoid	TO175T	3.7
Haematopoietic and lymphoid	TOLEDO	7.8
Haematopoietic and lymphoid	U266B1	3.8
Haematopoietic and lymphoid	U937	3.5
Haematopoietic and lymphoid	UT7	3.7
Haematopoietic and lymphoid	WSUDLCL2	3.6
Kidney	769P	3.8
Kidney	786O	3.7
Kidney	A498	3.5
Kidney	A704	3.7
Kidney	ACHN	3.4
Kidney	BFTC909	3.3
Kidney	CAKI1	3.6
Kidney	CAKI2	3.9
Kidney	CAL54	3.5
Kidney	KMRC1	3.7
Kidney	KMRC20	3.6
Kidney	KMRC2	3.7
Kidney	KMRC3	3.5
Kidney	OSRC2	3.6
Kidney	RCC10RGB	3.6
Kidney	SNU1272	3.4
Kidney	SNU349	3.7
Kidney	TUHR10TKB	3.5
Kidney	TUHR14TKB	3.5
Kidney	TUHR4TKB	3.4
Kidney	VMRCRCW	3.7
Kidney	VMRCRCZ	3.6
Large intestine	C2BBE1	3.6
Large intestine	CCK81	3.5
Large intestine	CL11	3.5
Large intestine	CL14	3.5
Large intestine	CL34	3.5
Large intestine	CL40	3.6
Large intestine	COLO205	3.6
Large intestine	COLO320	3.6
Large intestine	COLO678	3.4
Large intestine	CW2	3.4
Large intestine	DLD1	3.5
Large intestine	GP2D	3.6
Large intestine	HCC56	3.7
Large intestine	HCT116	4
Large intestine	HCT15	3.8
Large intestine	HS675T	3.5
Large intestine	HS698T	3.5
Large intestine	HT115	3.4
Large intestine	HT29	3.6
Large intestine	HT55	3.6
Large intestine	KM12	3.4
Large intestine	LOVO	3.3
Large intestine	LS1034	3.4
Large intestine	LS123	3.5
Large intestine	LS180	3.5
Large intestine	LS411N	3.5
Large intestine	LS513	3.5
Large intestine	MDST8	3.4
Large intestine	NCIH508	3.9
Large intestine	NCIH716	3.5
Large intestine	NCIH747	3.5
Large intestine	OUMS23	3.4
Large intestine	RCM1	3.9
Large intestine	RKO	3.7
Large intestine	SKCO1	3.4
Large intestine	SNU1040	3.7
Large intestine	SNU1197	3.3
Large intestine	SNU175	3.6
Large intestine	SNU283	3.9
Large intestine	SNU407	3.6
Large intestine	SNU503	3.6
Large intestine	SNU61	3.8
Large intestine	SNU81	3.7
Large intestine	SNUC1	3.7
Large intestine	SNUC2A	3.4
Large intestine	SNUC4	3.6
Large intestine	SNUC5	3.4
Large intestine	SW1116	3.8
Large intestine	SW1417	3.4
Large intestine	SW1463	3.6
Large intestine	SW403	3.6
Large intestine	SW480	3.4
Large intestine	SW48	3.4
Large intestine	SW620	3.8
Large intestine	SW837	3.6
Large intestine	SW948	3.6
Large intestine	T84	3.5
Liver	ALEXANDERCELLS	3.5
Liver	C3A	3.7
Liver	HEP3B217	3.4
Liver	HEPG2	3.6
Liver	HLE	3.5
Liver	HLF	3.5
Liver	HUH1	3.7
Liver	HUH6	3.4
Liver	HUH7	3.5
Liver	JHH1	3.6
Liver	JHH2	3.3
Liver	JHH4	3.4
Liver	JHH5	3.9
Liver	JHH6	3.8
Liver	JHH7	3.6
Liver	LI7	3.5
Liver	PLCPRF5	3.4
Liver	SKHEP1	3.5
Liver	SNU182	3.5
Liver	SNU387	3.7
Liver	SNU398	3.5
Liver	SNU423	3.6
Liver	SNU449	3.8
Liver	SNU475	3.4
Liver	SNU761	3.5
Liver	SNU878	3.6
Liver	SNU886	3.7
Lung	A549	3.4
Lung	ABC1	3.5
Lung	BEN	3.5
Lung	CAL12T	3.6
Lung	CALU1	3.6
Lung	CALU3	3.5
Lung	CALU6	3.4
Lung	CHAGOK1	3.6
Lung	COLO668	3.6
Lung	COLO699	3.5
Lung	CORL105	3.5
Lung	CORL23	3.5
Lung	CORL24	3.5
Lung	CORL279	3.4
Lung	CORL311	3.6
Lung	CORL47	3.4
Lung	CORL51	3.6
Lung	CORL88	3.6
Lung	CORL95	3.6
Lung	CPCN	3.9
Lung	DMS114	3.7
Lung	DMS153	3.3
Lung	DMS273	3.7
Lung	DMS454	3.4
Lung	DMS53	3.5
Lung	DMS79	3.4
Lung	DV90	3.6
Lung	EBC1	3.5
Lung	EPLC272H	3.8
Lung	HARA	3.8
Lung	HCC1171	3.4
Lung	HCC1195	3.6
Lung	HCC15	3.4
Lung	HCC2279	3.3
Lung	HCC2935	3.3
Lung	HCC33	3.5
Lung	HCC366	3.5
Lung	HCC4006	3.4
Lung	HCC44	3.7
Lung	HCC78	3.4
Lung	HCC827	3.4
Lung	HCC95	3.5
Lung	HLC1	3.4
Lung	HLFA	3.4
Lung	HS229T	3.6
Lung	HS618T	3.5
Lung	IALM	3.4
Lung	KNS62	3.5
Lung	LC1F	3.4
Lung	LC1SQSF	3.5
Lung	LCLC103H	3.3
Lung	LCLC97TM1	3.7
Lung	LK2	3.5
Lung	LOUNH91	3.8
Lung	LU65	3.6
Lung	LU99	3.3
Lung	LUDLU1	3.5
Lung	LXF289	3.5
Lung	MORCPR	3.5
Lung	NCIH1048	3.5
Lung	NCIH1092	3.6
Lung	NCIH1105	3.6
Lung	NCIH1155	3.4
Lung	NCIH1184	3.4
Lung	NCIH1299	3.7
Lung	NCIH1339	3.6
Lung	NCIH1341	3.6
Lung	NCIH1355	3.6
Lung	NCIH1373	3.6
Lung	NCIH1385	3.6
Lung	NCIH1395	3.6
Lung	NCIH1435	3.5
Lung	NCIH1436	3.3
Lung	NCIH1437	3.5
Lung	NCIH146	3.4
Lung	NCIH1563	3.7
Lung	NCIH1568	3.5
Lung	NCIH1573	3.7
Lung	NCIH1581	3.3
Lung	NCIH1618	3.4
Lung	NCIH1623	3.7
Lung	NCIH1648	3.7
Lung	NCIH1650	3.6
Lung	NCIH1651	3.6
Lung	NCIH1666	3.6
Lung	NCIH1693	3.4
Lung	NCIH1694	3.5
Lung	NCIH1703	3.4
Lung	NCIH1734	3.4
Lung	NCIH1755	3.5
Lung	NCIH1781	3.5
Lung	NCIH1792	3.8
Lung	NCIH1793	3.7
Lung	NCIH1836	3.6
Lung	NCIH1838	3.9
Lung	NCIH1869	3.8
Lung	NCIH1876	3.6
Lung	NCIH1915	3.5
Lung	NCIH1930	3.5
Lung	NCIH1944	3.4
Lung	NCIH1963	3.5
Lung	NCIH196	3.6
Lung	NCIH1975	3.4
Lung	NCIH2009	3.7
Lung	NCIH2023	3.5
Lung	NCIH2029	3.7
Lung	NCIH2030	3.5
Lung	NCIH2066	3.7
Lung	NCIH2081	3.5
Lung	NCIH2085	3.5
Lung	NCIH2087	3.8
Lung	NCIH209	3.5
Lung	NCIH2106	3.5
Lung	NCIH2110	3.4
Lung	NCIH211	3.9
Lung	NCIH2122	3.7
Lung	NCIH2126	3.4
Lung	NCIH2141	3.6
Lung	NCIH2170	3.8
Lung	NCIH2171	3.5
Lung	NCIH2172	3.7
Lung	NCIH2196	3.4
Lung	NCIH2227	4.1
Lung	NCIH2228	3.6
Lung	NCIH226	3.5
Lung	NCIH2286	3.3
Lung	NCIH2291	3.6
Lung	NCIH2342	3.3
Lung	NCIH2347	3.6
Lung	NCIH23	3.6
Lung	NCIH2405	3.4
Lung	NCIH2444	3.4
Lung	NCIH292	3.6
Lung	NCIH322	3.6
Lung	NCIH3255	3.4
Lung	NCIH358	3.3
Lung	NCIH441	3.8
Lung	NCIH446	3.5
Lung	NCIH460	3.2
Lung	NCIH510	3.6
Lung	NCIH520	3.6
Lung	NCIH522	3.6
Lung	NCIH524	3.5
Lung	NCIH526	3.5
Lung	NCIH596	3.5
Lung	NCIH647	3.6
Lung	NCIH650	3.9
Lung	NCIH661	3.4
Lung	NCIH69	3.6
Lung	NCIH727	3.5
Lung	NCIH810	3.6
Lung	NCIH82	3.5
Lung	NCIH838	3.5
Lung	NCIH841	3.3
Lung	NCIH854	3.5
Lung	NCIH889	3.7
Lung	PC14	3.4
Lung	RERFLCAD1	3.2
Lung	RERFLCAD2	3.5
Lung	RERFLCAI	3.5
Lung	RERFLCKJ	3.7
Lung	RERFLCMS	3.2
Lung	RERFLCSQ1	3.6
Lung	SBC5	3.5
Lung	SCLC21H	3.3
Lung	SHP77	4
Lung	SKLU1	3.5
Lung	SKMES1	3.6
Lung	SQ1	3.6
Lung	SW1271	3.3
Lung	SW1573	3.4
Lung	SW900	3.6
Lung	VMRCLCD	3.5
Lung	VMRCLCP	3.4
Oesophagus	COLO680N	3.4
Oesophagus	ECGI10	3.3
Oesophagus	KYSE140	3.4
Oesophagus	KYSE150	3.5
Oesophagus	KYSE180	3.5
Oesophagus	KYSE270	3.5
Oesophagus	KYSE30	3.5
Oesophagus	KYSE410	3.5
Oesophagus	KYSE450	3.6
Oesophagus	KYSE510	3.5
Oesophagus	KYSE520	3.5
Oesophagus	KYSE70	3.8
Oesophagus	OE19	3.7
Oesophagus	OE33	3.5
Oesophagus	TE10	3.7
Oesophagus	TE11	3.6
Oesophagus	TE14	3.4
Oesophagus	TE15	3.6
Oesophagus	TE1	3.6
Oesophagus	TE4	3.3
Oesophagus	TE5	3.3
Oesophagus	TE6	3.4
Oesophagus	TE8	3.4
Oesophagus	TE9	3.6
Oesophagus	TT	3.4
Ovary	59M	3.5
Ovary	A2780	3.4
Ovary	CAOV3	3.7
Ovary	CAOV4	3.6
Ovary	COLO704	3.5
Ovary	COV318	3.7
Ovary	COV362	3.5
Ovary	COV434	3.6
Ovary	COV504	3.7
Ovary	COV644	3.6
Ovary	EFO21	3.5
Ovary	EFO27	3.5
Ovary	ES2	3.6
Ovary	FUOV1	3.5
Ovary	HEYA8	3.3
Ovary	HS571T	3.6
Ovary	IGROV1	3.5
Ovary	JHOC5	3.6
Ovary	JHOM1	3.9
Ovary	JHOM2B	3.4
Ovary	JHOS2	3.5
Ovary	JHOS4	3.7
Ovary	KURAMOCHI	3.7
Ovary	MCAS	3.7
Ovary	NIHOVCAR3	3.5
Ovary	OAW28	3.5
Ovary	OAW42	3.5
Ovary	OC314	3.7
Ovary	OC316	3.5
Ovary	ONCODG1	3.3
Ovary	OV56	3.7
Ovary	OV7	3.6
Ovary	OV90	3.5
Ovary	OVCAR4	3.4
Ovary	OVCAR8	3.6
Ovary	OVISE	3.8
Ovary	OVK18	3.6
Ovary	OVKATE	3.6
Ovary	OVMANA	3.6
Ovary	OVSAHO	3.8
Ovary	OVTOKO	3.8
Ovary	RMGI	3.5
Ovary	RMUGS	3.7
Ovary	SKOV3	3.7
Ovary	SNU119	3.3
Ovary	SNU840	3.5
Ovary	SNU8	3.6
Ovary	TOV112D	3.7
Ovary	TOV21G	3.6
Ovary	TYKNU	3.7
Pancreas	ASPC1	3.7
Pancreas	BXPC3	3.5
Pancreas	CAPAN1	3.7
Pancreas	CAPAN2	3.5
Pancreas	CFPAC1	3.6
Pancreas	DANG	3.5
Pancreas	HPAC	3.5
Pancreas	HPAFII	3.6
Pancreas	HS766T	3.5
Pancreas	HUPT3	3.6
Pancreas	HUPT4	3.7
Pancreas	KCIMOH1	3.9
Pancreas	KLM1	3.5
Pancreas	KP2	3.5
Pancreas	KP3	3.5
Pancreas	KP4	3.6
Pancreas	L33	3.6
Pancreas	MIAPACA2	3.4
Pancreas	PANC0203	3.5
Pancreas	PANC0213	3.7
Pancreas	PANC0327	3.5
Pancreas	PANC0403	3.7
Pancreas	PANC0504	3.5
Pancreas	PANC0813	3.8
Pancreas	PANC1005	3.4
Pancreas	PANC1	3.7
Pancreas	PATU8902	3.6
Pancreas	PATU8988S	3.6
Pancreas	PATU8988T	3.7
Pancreas	PK1	3.5
Pancreas	PK45H	3.4
Pancreas	PK59	3.3
Pancreas	PL45	3.9
Pancreas	PSN1	3.3
Pancreas	QGP1	3.7
Pancreas	SNU213	3.5
Pancreas	SNU324	3.6
Pancreas	SNU410	3.9
Pancreas	SU8686	3.5
Pancreas	SUIT2	3.5
Pancreas	SW1990	3.9
Pancreas	T3M4	3.4
Pancreas	TCCPAN2	3.8
Pancreas	YAPC	4.3
Pleura	ACCMESO1	3.5
Pleura	DM3	3.6
Pleura	ISTMES1	3.4
Pleura	ISTMES2	3.5
Pleura	JL1	3.7
Pleura	MPP89	3.5
Pleura	MSTO211H	3.5
Pleura	NCIH2052	3.4
Pleura	NCIH2452	3.4
Pleura	NCIH28	3.9
Prostate	22RV1	3.5
Prostate	DU145	3.7
Prostate	LNCAPCLONEFGC	3.2
Prostate	MDAPCA2B	3.4
Prostate	NCIH660	3.5
Prostate	PC3	3.4
Prostate	VCAP	3.6
Salivary gland	A253	3.4
Salivary gland	YD15	3.5
Skin	A101D	3.7
Skin	A2058	3.7
Skin	A375	3.5
Skin	C32	3.6
Skin	CHL1	3.4
Skin	CJM	3.4
Skin	COLO679	3.4
Skin	COLO741	3.5
Skin	COLO783	3.6
Skin	COLO792	3.4
Skin	COLO800	3.6
Skin	COLO818	3.4
Skin	COLO829	3.4
Skin	COLO849	3.5
Skin	G361	3.4
Skin	GRM	3.5
Skin	HMCB	3.2
Skin	HS294T	3.6
Skin	HS600T	3.7
Skin	HS688AT	3.4
Skin	HS695T	3.5
Skin	HS839T	3.5
Skin	HS852T	3.5
Skin	HS895T	3.6
Skin	HS934T	3.6
Skin	HS936T	3.9
Skin	HS939T	3.7
Skin	HS940T	3.4
Skin	HS944T	3.8
Skin	HT144	3.3
Skin	IGR1	3.5
Skin	IGR37	3.4
Skin	IGR39	3.7
Skin	IPC298	3.8
Skin	K029AX	3.6
Skin	LOXIMVI	3.5
Skin	MALME3M	3.6
Skin	MDAMB435S	3.5
Skin	MELHO	3.6
Skin	MELJUSO	3.3
Skin	MEWO	3.4
Skin	RPMI7951	3.6
Skin	RVH421	3.4
Skin	SH4	3.4
Skin	SKMEL1	3.7
Skin	SKMEL24	3.5
Skin	SKMEL28	3.4
Skin	SKMEL2	3.7
Skin	SKMEL30	3.4
Skin	SKMEL31	3.3
Skin	SKMEL3	3.5
Skin	SKMEL5	3.6
Skin	UACC257	3.6
Skin	UACC62	3.5
Skin	WM115	3.4
Skin	WM1799	3.5
Skin	WM2664	3.5
Skin	WM793	3.6
Skin	WM88	3.5
Skin	WM983B	3.5
Small intestine	HUTU80	3.6
Soft tissue	A204	3.5
Soft tissue	G401	3.6
Soft tissue	G402	3.4
Soft tissue	GCT	3.7
Soft tissue	HS729	3.6
Soft tissue	HT1080	3.4
Soft tissue	KYM1	3.5
Soft tissue	MESSA	3.6
Soft tissue	RD	3.5
Soft tissue	RH30	3.5
Soft tissue	RH41	3.5
Soft tissue	RKN	3.5
Soft tissue	S117	3.5
Soft tissue	SJRH30	3.7
Soft tissue	SKLMS1	3.4
Soft tissue	SKUT1	3.5
Soft tissue	TE125T	3.4
Soft tissue	TE159T	3.9
Soft tissue	TE441T	3.4
Soft tissue	TE617T	3.5
Stomach	2313287	3.5
Stomach	AGS	3.4
Stomach	AZ521	3.6
Stomach	ECC10	3.4
Stomach	ECC12	3.3
Stomach	FU97	3.6
Stomach	GCIY	3.5
Stomach	GSS	3.5
Stomach	GSU	3.5
Stomach	HGC27	3.3
Stomach	HS746T	3.4
Stomach	HUG1N	3.6
Stomach	IM95	3.5
Stomach	KATOIII	3.3
Stomach	KE39	3.6
Stomach	LMSU	5.5
Stomach	MKN1	3.3
Stomach	MKN45	3.5
Stomach	MKN74	3.4
Stomach	MKN7	3.3
Stomach	NCCSTCK140	3.4
Stomach	NCIN87	3.6
Stomach	NUGC2	3.4
Stomach	NUGC3	3.6
Stomach	NUGC4	3.3
Stomach	OCUM1	3.8
Stomach	RERFGC1B	3.3
Stomach	SH10TC	3.5
Stomach	SNU16	3.5
Stomach	SNU1	3.6
Stomach	SNU216	3.7
Stomach	SNU520	3.4
Stomach	SNU5	3.8
Stomach	SNU601	3.9
Stomach	SNU620	3.5
Stomach	SNU668	3.7
Stomach	SNU719	4.1
Stomach	TGBC11TKB	3.5
Thyroid	8305C	3.3
Thyroid	8505C	3.2
Thyroid	BCPAP	3.6
Thyroid	BHT101	3.6
Thyroid	CAL62	3.9
Thyroid	CGTHW1	3.4
Thyroid	FTC133	3.6
Thyroid	FTC238	3.3
Thyroid	ML1	3.5
Thyroid	SW579	3.5
Thyroid	TT2609C02	3.3
Thyroid	TT	3.4
Upper aerodigestive tract	BHY	3.5
Upper aerodigestive tract	BICR16	3.5
Upper aerodigestive tract	BICR18	3.4
Upper aerodigestive tract	BICR22	3.5
Upper aerodigestive tract	BICR31	3.3
Upper aerodigestive tract	BICR56	3.4
Upper aerodigestive tract	BICR6	3.6
Upper aerodigestive tract	CAL27	3.4
Upper aerodigestive tract	CAL33	3.6
Upper aerodigestive tract	DETROIT562	3.6
Upper aerodigestive tract	FADU	3.5
Upper aerodigestive tract	HS840T	3.7
Upper aerodigestive tract	HSC2	3.3
Upper aerodigestive tract	HSC3	3.3
Upper aerodigestive tract	HSC4	3.4
Upper aerodigestive tract	PECAPJ15	3.8
Upper aerodigestive tract	PECAPJ34CLONEC12	3.8
Upper aerodigestive tract	PECAPJ41CLONED2	3.8
Upper aerodigestive tract	PECAPJ49	3.5
Upper aerodigestive tract	SCC15	3.5
Upper aerodigestive tract	SCC25	3.5
Upper aerodigestive tract	SCC4	3.7
Upper aerodigestive tract	SCC9	3.6
Upper aerodigestive tract	SNU1076	3.6
Upper aerodigestive tract	SNU1214	3.7
Upper aerodigestive tract	SNU46	3.6
Upper aerodigestive tract	SNU899	3.7
Upper aerodigestive tract	YD10B	3.7
Upper aerodigestive tract	YD38	3.6
Upper aerodigestive tract	YD8	3.5
Urinary tract	5637	3.5
Urinary tract	639V	3.4
Urinary tract	647V	3.4
Urinary tract	BC3C	3.6
Urinary tract	BFTC905	3.5
Urinary tract	CAL29	3.4
Urinary tract	HS172T	3.6
Urinary tract	HT1197	3.6
Urinary tract	HT1376	3.7
Urinary tract	J82	3.5
Urinary tract	JMSU1	3.5
Urinary tract	KMBC2	3.5
Urinary tract	KU1919	3.6
Urinary tract	RT11284	3.5
Urinary tract	RT112	3.8
Urinary tract	RT4	3.4
Urinary tract	SCABER	3.6
Urinary tract	SW1710	3.5
Urinary tract	SW780	3.5
Urinary tract	T24	3.6
Urinary tract	TCCSUP	3.8
Urinary tract	UMUC1	3.8
Urinary tract	UMUC3	3.3
Urinary tract	VMCUB1	3.5

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	0
Adrenal gland	0
Appendix	0
Bone marrow	0.9
Breast	0
Cerebral cortex	0
Cervix, uterine	0
Colon	0
Duodenum	0
Endometrium	0
Epididymis	0.2
Esophagus	0
Fallopian tube	0
Gallbladder	0.2
Heart muscle	0
Kidney	0.3
Liver	0
Lung	0
Lymph node	0.1
Ovary	0
Pancreas	0
Parathyroid gland	0
Placenta	0
Prostate	0
Rectum	0
Salivary gland	0
Seminal vesicle	0
Skeletal muscle	0
Skin	0
Small intestine	0
Smooth muscle	0
Spleen	0
Stomach	0
Testis	1.8
Thyroid gland	40
Tonsil	0.4
Urinary bladder	0

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
27301862	overexpression	Waldenstrom Macroglobulinemia	Compared with healthy donors, WM patient samples showed greatly enhanced expression of the VDJ recombination genes DNTT, RAG1, and RAG2, but not AICDA Genes related to CXCR4 signaling were also upregulated and included CXCR4, CXCL12, and VCAM1 regardless of CXCR4 mutation status, indicating a potential role for CXCR4 signaling in all WM patients.
14521728	aberrant expression	Colon Adenocarcinoma	The human epithelial cancer cell line (SW480) positively expressed SNC73, RAG1, and RAG2.

Summary
Symbol	RAG2
Name	recombination activating 2
Aliases	RAG-2; V(D)J recombination-activating protein 2
Location	11p13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
LAML	Acute Myeloid Leukemia	166	0.136	0.0796	1.8	95.8	2.4	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.185	0.0182	32.7	64.8	2.5	Neutral
THCA	Thyroid carcinoma	497	-0.077	0.0871	1.4	97.4	1.2	Neutral
THYM	Thymoma	119	0.186	0.0428	7.6	91.6	0.8	Neutral

Summary
Symbol	RAG2
Name	recombination activating 2
Aliases	RAG-2; V(D)J recombination-activating protein 2
Location	11p13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
LAML	Acute Myeloid Leukemia	-0.344	5.03e-06	0	170	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.393	3.55e-08	3	184	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.217	2.36e-07	50	509	0.029	0.976	NS/NA
THYM	Thymoma	-0.865	0	2	120	NA	NA	NS/NA

Summary
Symbol	RAG2
Name	recombination activating 2
Aliases	RAG-2; V(D)J recombination-activating protein 2
Location	11p13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA) [ TOP ]
There is no antibody staining data.

Summary
Symbol	RAG2
Name	recombination activating 2
Aliases	RAG-2; V(D)J recombination-activating protein 2
Location	11p13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
THCA	Thyroid carcinoma	391	3.77e-25	Significant	25417114

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
LAML	Acute Myeloid Leukemia	149	0.761	0.349	NS
PCPG	Pheochromocytoma and Paraganglioma	179	2.045	0.551	NS
THCA	Thyroid carcinoma	500	2.195	0.176	NS
THYM	Thymoma	119	0	0.00902	Longer

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
THCA	Thyroid carcinoma	499	-0.062	0.168	NS

> Grade [ TOP ]
There is no data.

Summary
Symbol	RAG2
Name	recombination activating 2
Aliases	RAG-2; V(D)J recombination-activating protein 2
Location	11p13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	RAG2
Name	recombination activating 2
Aliases	RAG-2; V(D)J recombination-activating protein 2
Location	11p13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for RAG2.

Summary
Symbol	RAG2
Name	recombination activating 2
Aliases	RAG-2; V(D)J recombination-activating protein 2
Location	11p13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]
There is no record for RAG2.

> Interactions from Text Mining [ TOP ]
There is no record for RAG2.