CR2Cancer

Summary
Symbol	RBBP7
Name	RB binding protein 7, chromatin remodeling factor
Aliases	RbAp46; G1/S transition control protein-binding protein RbAp46; retinoblastoma-binding protein 7; retinoblas ......
Location	Xp22.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

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Domain

PF12265 Histone-binding protein RBBP4 or subunit C of CAF1 complex
PF00400 WD domain

Function

Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.

Classification

Class	Modification	Substrate	Product	PubMed
Histone chaperone	#	H4	#	18571423

> Gene Ontology [ TOP ]
Biological Process	GO:0001558 regulation of cell growth GO:0006260 DNA replication GO:0006323 DNA packaging GO:0006333 chromatin assembly or disassembly GO:0006334 nucleosome assembly GO:0006336 DNA replication-independent nucleosome assembly GO:0006338 chromatin remodeling GO:0006476 protein deacetylation GO:0009266 response to temperature stimulus GO:0009408 response to heat GO:0010286 heat acclimation GO:0016049 cell growth GO:0016570 histone modification GO:0016575 histone deacetylation GO:0030308 negative regulation of cell growth GO:0031055 chromatin remodeling at centromere GO:0031497 chromatin assembly GO:0034080 CENP-A containing nucleosome assembly GO:0034508 centromere complex assembly GO:0034605 cellular response to heat GO:0034724 DNA replication-independent nucleosome organization GO:0034728 nucleosome organization GO:0035601 protein deacylation GO:0040029 regulation of gene expression, epigenetic GO:0043044 ATP-dependent chromatin remodeling GO:0043486 histone exchange GO:0045814 negative regulation of gene expression, epigenetic GO:0045926 negative regulation of growth GO:0048545 response to steroid hormone GO:0061641 CENP-A containing chromatin organization GO:0065004 protein-DNA complex assembly GO:0070370 cellular heat acclimation GO:0071103 DNA conformation change GO:0071824 protein-DNA complex subunit organization GO:0072331 signal transduction by p53 class mediator GO:0098732 macromolecule deacylation GO:1901796 regulation of signal transduction by p53 class mediator
Molecular Function	GO:0004407 histone deacetylase activity GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides GO:0019213 deacetylase activity GO:0033558 protein deacetylase activity
Cellular Component	GO:0000118 histone deacetylase complex GO:0016581 NuRD complex GO:0017053 transcriptional repressor complex GO:0031519 PcG protein complex GO:0034708 methyltransferase complex GO:0035097 histone methyltransferase complex GO:0035098 ESC/E(Z) complex GO:0070603 SWI/SNF superfamily-type complex GO:0090545 CHD-type complex GO:0090568 nuclear transcriptional repressor complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-5619507: Activation of HOX genes during differentiation R-HSA-5617472: Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-1640170: Cell Cycle R-HSA-2559583: Cellular Senescence R-HSA-2262752: Cellular responses to stress R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-73886: Chromosome Maintenance R-HSA-606279: Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-1266738: Developmental Biology R-HSA-427389: ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-212165: Epigenetic regulation of gene expression R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-3214847: HATs acetylate histones R-HSA-3214815: HDACs deacetylate histones R-HSA-774815: Nucleosome assembly R-HSA-2559580: Oxidative Stress Induced Senescence R-HSA-3214841: PKMTs methylate histone lysines R-HSA-212300: PRC2 methylates histones and DNA R-HSA-5250913: Positive epigenetic regulation of rRNA expression R-HSA-3214858: RMTs methylate histone arginines R-HSA-73854: RNA Polymerase I Promoter Clearance R-HSA-73864: RNA Polymerase I Transcription R-HSA-73762: RNA Polymerase I Transcription Initiation R-HSA-504046: RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription R-HSA-5633007: Regulation of TP53 Activity R-HSA-6804758: Regulation of TP53 Activity through Acetylation R-HSA-3700989: Transcriptional Regulation by TP53

> KEGG and Reactome Pathway

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KEGG

Reactome

R-HSA-5619507: Activation of HOX genes during differentiation
R-HSA-5617472: Activation of anterior HOX genes in hindbrain development during early embryogenesis
R-HSA-1640170: Cell Cycle
R-HSA-2559583: Cellular Senescence
R-HSA-2262752: Cellular responses to stress
R-HSA-3247509: Chromatin modifying enzymes
R-HSA-4839726: Chromatin organization
R-HSA-73886: Chromosome Maintenance
R-HSA-606279: Deposition of new CENPA-containing nucleosomes at the centromere
R-HSA-1266738: Developmental Biology
R-HSA-427389: ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
R-HSA-212165: Epigenetic regulation of gene expression
R-HSA-74160: Gene Expression
R-HSA-212436: Generic Transcription Pathway
R-HSA-3214847: HATs acetylate histones
R-HSA-3214815: HDACs deacetylate histones
R-HSA-774815: Nucleosome assembly
R-HSA-2559580: Oxidative Stress Induced Senescence
R-HSA-3214841: PKMTs methylate histone lysines
R-HSA-212300: PRC2 methylates histones and DNA
R-HSA-5250913: Positive epigenetic regulation of rRNA expression
R-HSA-3214858: RMTs methylate histone arginines
R-HSA-73854: RNA Polymerase I Promoter Clearance
R-HSA-73864: RNA Polymerase I Transcription
R-HSA-73762: RNA Polymerase I Transcription Initiation
R-HSA-504046: RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
R-HSA-5633007: Regulation of TP53 Activity
R-HSA-6804758: Regulation of TP53 Activity through Acetylation
R-HSA-3700989: Transcriptional Regulation by TP53

Summary
Symbol	RBBP7
Name	RB binding protein 7, chromatin remodeling factor
Aliases	RbAp46; G1/S transition control protein-binding protein RbAp46; retinoblastoma-binding protein 7; retinoblas ......
Location	Xp22.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

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COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM233236	c.592G>A	p.D198N	Substitution - Missense	Skin
COSM3424653	c.1222T>G	p.Y408D	Substitution - Missense	Large_intestine
COSM5345963	c.597+10G>A	p.?	Unknown	Large_intestine
COSM1118562	c.1024A>C	p.N342H	Substitution - Missense	Endometrium
COSM1118564	c.781A>C	p.T261P	Substitution - Missense	Endometrium
COSM1467015	c.958T>G	p.F320V	Substitution - Missense	Large_intestine
COSM3992427	c.1101T>C	p.F367F	Substitution - coding silent	Kidney
COSM314705	c.308-1G>T	p.?	Unknown	Soft_tissue
COSM296785	c.1247C>T	p.T416M	Substitution - Missense	Large_intestine
COSM181884	c.382C>T	p.R128C	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1467013	c.1159delT	p.W387fs*>39	Deletion - Frameshift	Large_intestine
COSM4772070	c.416T>C	p.I139T	Substitution - Missense	Stomach
COSM1118567	c.621C>T	p.N207N	Substitution - coding silent	Endometrium
COSM5366755	c.1073_1081delCAGAAGATG	p.A358_D360delAED	Deletion - In frame	Large_intestine
COSM4844483	c.949G>A	p.D317N	Substitution - Missense	Cervix
COSM1118561	c.1098+4C>T	p.?	Unknown	Endometrium
COSM4108374	c.1007G>A	p.G336D	Substitution - Missense	Stomach
COSM25323	c.827A>G	p.N276S	Substitution - Missense	Upper_aerodigestive_tract
COSM1118563	c.941C>A	p.S314Y	Substitution - Missense	Endometrium
COSM5617531	c.17-10C>T	p.?	Unknown	Lung
COSM5954082	c.759-1G>A	p.?	Unknown	Upper_aerodigestive_tract
COSM1625748	c.842A>G	p.N281S	Substitution - Missense	Liver
COSM1467019	c.43G>A	p.V15I	Substitution - Missense	Large_intestine
COSM3913711	c.943C>T	p.H315Y	Substitution - Missense	Skin
COSM5476906	c.1262A>C	p.E421A	Substitution - Missense	Large_intestine
COSM233236	c.592G>A	p.D198N	Substitution - Missense	Skin
COSM277022	c.820G>A	p.E274K	Substitution - Missense	Large_intestine
COSM117170	c.889G>T	p.V297L	Substitution - Missense	Ovary
COSM4650868	c.610T>C	p.W204R	Substitution - Missense	Large_intestine
COSM3035411	c.1254C>T	p.S418S	Substitution - coding silent	Large_intestine
COSM3390545	c.878C>T	p.A293V	Substitution - Missense	Pancreas
COSM3424654	c.1100T>G	p.F367C	Substitution - Missense	Large_intestine
COSM372335	c.652G>T	p.A218S	Substitution - Missense	Lung
COSM300111	c.1019G>A	p.R340H	Substitution - Missense	Large_intestine
COSM1118572	c.83C>T	p.P28L	Substitution - Missense	Endometrium
COSM1625749	c.142T>C	p.W48R	Substitution - Missense	Liver
COSM1490739	c.1209+1G>T	p.?	Unknown	Breast
COSM1625748	c.842A>G	p.N281S	Substitution - Missense	Liver
COSM246967	c.482-1G>C	p.?	Unknown	Prostate
COSM246966	c.1076A>G	p.E359G	Substitution - Missense	Prostate
COSM3414261	c.17-8A>G	p.?	Unknown	Oesophagus
COSM5412375	c.637G>A	p.G213S	Substitution - Missense	Skin
COSM5028854	c.1012G>A	p.D338N	Substitution - Missense	Breast
COSM5367497	c.923A>G	p.K308R	Substitution - Missense	Large_intestine
COSM1118571	c.367G>A	p.E123K	Substitution - Missense	Endometrium
COSM314705	c.308-1G>T	p.?	Unknown	Lung
COSM4108376	c.826A>C	p.N276H	Substitution - Missense	Stomach
COSM403537	c.520G>A	p.G174S	Substitution - Missense	Lung
COSM1118568	c.609G>A	p.L203L	Substitution - coding silent	Endometrium
COSM329698	c.959delT	p.F320fs*22	Deletion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM1756479	c.72G>A	p.K24K	Substitution - coding silent	Urinary_tract
COSM1490740	c.715G>C	p.E239Q	Substitution - Missense	Breast
COSM1118565	c.707T>C	p.L236P	Substitution - Missense	Endometrium
COSM5669839	c.545T>C	p.L182P	Substitution - Missense	Soft_tissue
COSM219021	c.908G>A	p.R303H	Substitution - Missense	Pancreas
COSM1756479	c.72G>A	p.K24K	Substitution - coding silent	Urinary_tract
COSM4434800	c.1202G>A	p.W401*	Substitution - Nonsense	Oesophagus
COSM4720586	c.506A>C	p.D169A	Substitution - Missense	Large_intestine
COSM1118570	c.501T>G	p.N167K	Substitution - Missense	Endometrium
COSM3035433	c.49A>G	p.N17D	Substitution - Missense	Large_intestine
COSM5628362	c.1111G>A	p.G371R	Substitution - Missense	Oesophagus
COSM25323	c.827A>G	p.N276S	Substitution - Missense	Upper_aerodigestive_tract
COSM1118566	c.634G>T	p.E212*	Substitution - Nonsense	Endometrium
COSM5730584	c.670G>A	p.G224S	Substitution - Missense	Breast
COSM1118571	c.367G>A	p.E123K	Substitution - Missense	Endometrium
COSM4629005	c.764A>G	p.D255G	Substitution - Missense	Large_intestine
COSM1467018	c.75_77delGAA	p.K25delK	Deletion - In frame	Large_intestine
COSM3913711	c.943C>T	p.H315Y	Substitution - Missense	Skin
COSM219021	c.908G>A	p.R303H	Substitution - Missense	Pancreas
COSM4544941	c.234G>C	p.L78L	Substitution - coding silent	Skin
COSM5823579	c.123G>C	p.W41C	Substitution - Missense	Liver
COSM246965	c.384T>C	p.R128R	Substitution - coding silent	Prostate
COSM1118569	c.539A>G	p.Y180C	Substitution - Missense	Endometrium
COSM308193	c.98_109del12	p.L33_T36delLVMT	Deletion - In frame	Biliary_tract
COSM219021	c.908G>A	p.R303H	Substitution - Missense	Large_intestine
COSM3965009	c.184C>T	p.L62F	Substitution - Missense	Lung
COSM4720587	c.212C>T	p.T71M	Substitution - Missense	Large_intestine
COSM5064568	c.590A>G	p.D197G	Substitution - Missense	Stomach
COSM277022	c.820G>A	p.E274K	Substitution - Missense	Large_intestine
COSM4720588	c.184C>A	p.L62I	Substitution - Missense	Large_intestine
COSM181884	c.382C>T	p.R128C	Substitution - Missense	Large_intestine
COSM300111	c.1019G>A	p.R340H	Substitution - Missense	Large_intestine
COSM4108375	c.831C>T	p.C277C	Substitution - coding silent	Stomach
COSM1467014	c.1015C>A	p.R339S	Substitution - Missense	Large_intestine
COSM300111	c.1019G>A	p.R340H	Substitution - Missense	Large_intestine
COSM5064567	c.853G>A	p.E285K	Substitution - Missense	Stomach
COSM488204	c.810G>A	p.A270A	Substitution - coding silent	Stomach
COSM181884	c.382C>T	p.R128C	Substitution - Missense	Stomach
COSM4654544	c.625G>T	p.G209*	Substitution - Nonsense	Large_intestine
COSM181884	c.382C>T	p.R128C	Substitution - Missense	Large_intestine
COSM3390544	c.1039A>T	p.S347C	Substitution - Missense	Pancreas
COSM5041931	c.1098+1G>A	p.?	Unknown	Liver
COSM300111	c.1019G>A	p.R340H	Substitution - Missense	Large_intestine
COSM277022	c.820G>A	p.E274K	Substitution - Missense	Large_intestine
COSM1118560	c.1132G>A	p.D378N	Substitution - Missense	Endometrium
COSM3844200	c.88C>A	p.L30I	Substitution - Missense	Breast
COSM80429	c.936C>T	p.F312F	Substitution - coding silent	Ovary
COSM3800514	c.1106A>T	p.H369L	Substitution - Missense	Urinary_tract
COSM1118573	c.25G>T	p.D9Y	Substitution - Missense	Endometrium
COSM3844199	c.1255G>A	p.E419K	Substitution - Missense	Breast
COSM1663847	c.151G>A	p.E51K	Substitution - Missense	Kidney
COSM488203	c.963+2T>C	p.?	Unknown	Kidney
COSM1625749	c.142T>C	p.W48R	Substitution - Missense	Liver
COSM756688	c.232C>T	p.L78L	Substitution - coding silent	Lung
COSM1467018	c.75_77delGAA	p.K25delK	Deletion - In frame	Biliary_tract
COSM5429009	c.87T>G	p.F29L	Substitution - Missense	Oesophagus
COSM4108377	c.414C>T	p.I138I	Substitution - coding silent	Stomach
COSM168298	c.937G>A	p.E313K	Substitution - Missense	Large_intestine

> Text Mining based Variations [ TOP ]
There is no record for RBBP7.

Summary
Symbol	RBBP7
Name	RB binding protein 7, chromatin remodeling factor
Aliases	RbAp46; G1/S transition control protein-binding protein RbAp46; retinoblastoma-binding protein 7; retinoblas ......
Location	Xp22.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

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Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
Q16576	3	S	Phosphoserine	-	No	None detected
Q16576	4	K	N6-acetyllysine	-	Yes	p.K4fs (cancer: LUAD)
Q16576	10	T	Phosphothreonine	-	No	None detected
Q16576	95	S	Phosphoserine	-	No	None detected
Q16576	119	K	N6-acetyllysine	-	No	None detected
Q16576	159	K	N6-acetyllysine	-	No	None detected
Q16576	354	S	Phosphoserine	-	Yes	p.S354* (cancer: LUAD)

Summary
Symbol	RBBP7
Name	RB binding protein 7, chromatin remodeling factor
Aliases	RbAp46; G1/S transition control protein-binding protein RbAp46; retinoblastoma-binding protein 7; retinoblas ......
Location	Xp22.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

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Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	7.083	7.127	0.04	0.797	NS
BRCA	Breast invasive carcinoma	112	1100	6.79	7.474	0.755	2.26e-29	Over
CESC	Cervical and endocervical cancers	3	306	7.533	7.739	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	6.791	7.398	0.576	8.73e-11	NS
ESCA	Esophageal carcinoma	11	185	6.759	6.962	0.093	0.717	NS
GBM	Glioblastoma multiforme	5	166	6.654	7.387	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	6.588	6.626	0.067	0.458	NS
KIRC	Kidney renal clear cell carcinoma	72	534	6.567	6.434	-0.114	0.00761	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	6.458	6.611	0.157	0.045	NS
LAML	Acute Myeloid Leukemia	0	173	NA	7.026	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	7.197	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	5.649	6.113	0.5	4.89e-12	NS
LUAD	Lung adenocarcinoma	59	517	6.325	6.752	0.431	4.16e-11	NS
LUSC	Lung squamous cell carcinoma	51	501	6.278	7.069	0.797	3.54e-21	Over
OV	Ovarian serous cystadenocarcinoma	0	307	NA	7.282	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	6.771	6.772	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	9.817	6.512	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	7.226	6.903	-0.5	6.3e-18	NS
READ	Rectum adenocarcinoma	10	167	7.057	7.43	0.433	0.0212	NS
SARC	Sarcoma	2	263	7.083	7.423	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	6.855	7.061	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	6.889	7.04	0.105	0.313	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	6.693	NA	NA	NA
THCA	Thyroid carcinoma	59	509	6.874	6.953	0.081	0.00571	NS
THYM	Thymoma	2	120	7.215	7.406	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	7.286	7.917	0.519	0.000568	NS

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	53.8
Adrenal gland	377.8
Appendix	79.8
Bone marrow	62.4
Breast	79.1
Cerebral cortex	80.6
Cervix, uterine	200.8
Colon	71.8
Duodenum	57.4
Endometrium	152.5
Epididymis	355.9
Esophagus	75.3
Fallopian tube	153.9
Gallbladder	79.4
Heart muscle	59.5
Kidney	65.2
Liver	29.4
Lung	64.8
Lymph node	106.3
Ovary	164.1
Pancreas	9.8
Parathyroid gland	297.4
Placenta	138
Prostate	134.8
Rectum	82.4
Salivary gland	27.1
Seminal vesicle	234.8
Skeletal muscle	31.8
Skin	73.2
Small intestine	65.3
Smooth muscle	148
Spleen	66.9
Stomach	49.7
Testis	177.9
Thyroid gland	97.3
Tonsil	101.6
Urinary bladder	66.1

> Text Mining based Expression

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PMID	Expression	Cancer	Evidence
25885317	overexpression	Bladder Carcinoma	High expression of Ras protein accompanied with high RbAp46 and low RECK expression were detected in 75% (3/4) of the clinical bladder cancer tumor tissues compared to the adjacent normal parts.
20920292	overexpression	Brain Neoplasm	For this purpose, we queried the Oncomine database and found that 4 PcG genes (EZH2, RBBP7, SUZ12, YY1) are specifically expressed in brain tumors.
20455597	aberrant expression	Chromophobe Renal Cell Carcinoma; Renal Cell Carcinoma	Of these, RBBP7 and HSP27 were highly expressed in the chromophobe subtype of RCC (3/3) but were absent from conventional RCC (0/3).
19655816	overexpression	Non-Small Cell Lung Carcinoma	Both of RbAp46 mRNA and protein levels were upregulated significantly in NSCLC cancer tissues.
17314274	overexpression	Breast Carcinoma	Reverse transcription-PCR data show high expression of putative tumor suppressor genes Rsk4 and RbAp46 in 47% and 79% of breast carcinoma cases, respectively, whereas Cldn2 was down-regulated in 52% of breast cancer cases compared with normal adjacent tissues.
16251025	overexpression	Leukemia	RbAp46 expression levels in ALs and CML-BC were strikingly higher than that in non-leukemias and CML-CP, and might participate in leukemogenesis.
14666671	underexpression	Breast Carcinoma	Here, we found that RbAp46 expression levels were decreased in five established breast cancer cell lines compared to a normal mammary gland epithelial cell line.
26254420	aberrant expression	Pleural Malignant Mesothelioma	In the Gordon Mesothelioma Study, 34 of them were assessed out of which SUMO1, UBC3, KIAA0101, HDAC2, DAXX, RBBP4, BBS1, NONO, RBBP7, HTRA2, and STUB1 were significantly overexpressed whereas TRAF6 and MTA2 were significantly underexpressed in MPM patients (network 2).

Summary
Symbol	RBBP7
Name	RB binding protein 7, chromatin remodeling factor
Aliases	RbAp46; G1/S transition control protein-binding protein RbAp46; retinoblastoma-binding protein 7; retinoblas ......
Location	Xp22.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.295	1.58e-09	19.6	61.9	18.6	Neutral
BRCA	Breast invasive carcinoma	1075	0.308	5.51e-25	17.7	65	17.3	Neutral
CESC	Cervical and endocervical cancers	292	0.278	1.41e-06	21.6	61.3	17.1	Neutral
COAD	Colon adenocarcinoma	449	0.303	5.11e-11	15.4	67.7	16.9	Neutral
ESCA	Esophageal carcinoma	183	0.472	1.51e-11	35.5	48.6	15.8	Loss
GBM	Glioblastoma multiforme	147	0.094	0.257	25.2	69.4	5.4	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.434	4.87e-25	29.2	61.5	9.3	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.249	7.46e-09	9.7	84.8	5.5	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	-0.252	1.5e-05	11.5	57.3	31.2	Neutral
LAML	Acute Myeloid Leukemia	166	0.266	0.000519	3	95.8	1.2	Neutral
LGG	Brain Lower Grade Glioma	513	0.162	0.000228	20.5	74.3	5.3	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.114	0.0291	29.9	59.9	10.2	Neutral
LUAD	Lung adenocarcinoma	512	0.318	1.8e-13	26.4	63.1	10.5	Neutral
LUSC	Lung squamous cell carcinoma	498	0.451	2.69e-26	28.7	55.2	16.1	Neutral
OV	Ovarian serous cystadenocarcinoma	300	0.305	7.19e-08	56	26.3	17.7	Loss
PAAD	Pancreatic adenocarcinoma	177	0.228	0.00226	14.7	79.7	5.6	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.27	0.000516	27.8	67.9	4.3	Neutral
PRAD	Prostate adenocarcinoma	491	0.355	5.06e-16	4.7	89.8	5.5	Neutral
READ	Rectum adenocarcinoma	164	0.412	4.1e-08	17.1	64	18.9	Neutral
SARC	Sarcoma	255	0.316	2.52e-07	24.3	42	33.7	Gain
SKCM	Skin Cutaneous Melanoma	367	0.154	0.00319	22.9	61.9	15.3	Neutral
STAD	Stomach adenocarcinoma	413	0.351	1.89e-13	15.7	68.8	15.5	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.119	0.147	18	62.7	19.3	Neutral
THCA	Thyroid carcinoma	497	0.142	0.00149	0.6	97.6	1.8	Neutral
THYM	Thymoma	119	0.164	0.075	6.7	91.6	1.7	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.261	8.49e-10	14.3	70.8	14.9	Neutral

Summary
Symbol	RBBP7
Name	RB binding protein 7, chromatin remodeling factor
Aliases	RbAp46; G1/S transition control protein-binding protein RbAp46; retinoblastoma-binding protein 7; retinoblas ......
Location	Xp22.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.241	5.17e-07	17	408	-0.002	0.0574	NS/NA
BRCA	Breast invasive carcinoma	-0.388	0	83	785	-0.052	5.04e-10	NS/NA
CESC	Cervical and endocervical cancers	-0.297	1.23e-07	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.316	1.16e-08	19	297	-0.003	0.0616	NS/NA
ESCA	Esophageal carcinoma	-0.454	4.03e-11	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.188	0.134	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.218	3.26e-07	20	522	0.003	0.00776	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.206	0.00013	24	319	0.006	6.92e-11	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.171	0.00315	23	275	0.002	0.0224	NS/NA
LAML	Acute Myeloid Leukemia	-0.139	0.0703	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.207	1.55e-06	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.224	4.52e-06	41	373	-0.009	2.7e-05	NS/NA
LUAD	Lung adenocarcinoma	-0.177	0.000102	21	456	0	1.55e-08	NS/NA
LUSC	Lung squamous cell carcinoma	-0.299	3.5e-09	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.85	0.00607	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.196	0.00785	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.153	0.0366	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.064	0.14	35	498	0.005	2.39e-07	NS/NA
READ	Rectum adenocarcinoma	-0.509	8.35e-08	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.393	5.62e-11	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.227	6.68e-07	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.363	7.28e-13	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.603	0	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.191	5.97e-06	50	509	-0.044	0.123	NS/NA
THYM	Thymoma	-0.065	0.477	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.222	1.41e-06	34	431	-0.111	4.38e-13	NS/NA

Summary
Symbol	RBBP7
Name	RB binding protein 7, chromatin remodeling factor
Aliases	RbAp46; G1/S transition control protein-binding protein RbAp46; retinoblastoma-binding protein 7; retinoblas ......
Location	Xp22.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	3	High
Appendix	3	High
Bone marrow	3	High
Breast	3	High
Bronchus	3	High
Caudate	3	High
Cerebellum	3	High
Cerebral cortex	3	High
Cervix, uterine	3	High
Colon	3	High
Duodenum	3	High
Endometrium	3	High
Epididymis	3	High
Esophagus	3	High
Fallopian tube	3	High
Gallbladder	3	High
Heart muscle	3	High
Hippocampus	3	High
Kidney	3	High
Liver	3	High
Lung	3	High
Lymph node	3	High
Nasopharynx	3	High
Oral mucosa	3	High
Ovary	3	High
Pancreas	3	High
Parathyroid gland	3	High
Placenta	3	High
Prostate	3	High
Rectum	3	High
Salivary gland	3	High
Seminal vesicle	3	High
Skeletal muscle	3	High
Skin	3	High
Small intestine	3	High
Smooth muscle	3	High
Soft tissue	3	High
Spleen	3	High
Stomach	3	High
Testis	3	High
Thyroid gland	3	High
Tonsil	3	High
Urinary bladder	3	High
Vagina	3	High

Summary
Symbol	RBBP7
Name	RB binding protein 7, chromatin remodeling factor
Aliases	RbAp46; G1/S transition control protein-binding protein RbAp46; retinoblastoma-binding protein 7; retinoblas ......
Location	Xp22.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.379	NS	24476821
BRCA	Breast invasive carcinoma	521	1.52e-05	Significant	23000897
COAD	Colon adenocarcinoma	149	0.00227	Significant	22810696
GBM	Glioblastoma multiforme	157	0.0533	NS	26824661
HNSC	Head and Neck squamous cell carcinoma	279	1.39e-05	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	1.16e-06	Significant	26536169
LGG	Brain Lower Grade Glioma	513	3.13e-20	Significant	26824661
LUAD	Lung adenocarcinoma	230	9.23e-06	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	7.33e-07	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	7.74e-07	Significant	21720365
PRAD	Prostate adenocarcinoma	333	7.01e-15	Significant	26544944
READ	Rectum adenocarcinoma	67	0.351	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.627	NS	26091043
STAD	Stomach adenocarcinoma	277	0.00114	Significant	25079317
THCA	Thyroid carcinoma	391	0.175	NS	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	6.35e-08	Significant	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	0.803	0.299	NS
BRCA	Breast invasive carcinoma	1079	0.915	0.695	NS
CESC	Cervical and endocervical cancers	291	0.868	0.665	NS
COAD	Colon adenocarcinoma	439	0.686	0.175	NS
ESCA	Esophageal carcinoma	184	2.669	0.00251	Shorter
GBM	Glioblastoma multiforme	158	0.858	0.552	NS
HNSC	Head and Neck squamous cell carcinoma	518	0.933	0.719	NS
KIRC	Kidney renal clear cell carcinoma	531	1.166	0.47	NS
KIRP	Kidney renal papillary cell carcinoma	287	2.336	0.0207	Shorter
LAML	Acute Myeloid Leukemia	149	1.235	0.449	NS
LGG	Brain Lower Grade Glioma	511	0.466	0.00235	Longer
LIHC	Liver hepatocellular carcinoma	365	1.818	0.0105	Shorter
LUAD	Lung adenocarcinoma	502	1.639	0.0219	Shorter
LUSC	Lung squamous cell carcinoma	494	0.708	0.0662	NS
OV	Ovarian serous cystadenocarcinoma	303	0.692	0.0781	NS
PAAD	Pancreatic adenocarcinoma	177	1.308	0.358	NS
PCPG	Pheochromocytoma and Paraganglioma	179	594299982.115	0.317	NS
PRAD	Prostate adenocarcinoma	497	1.702	0.556	NS
READ	Rectum adenocarcinoma	159	0.848	0.757	NS
SARC	Sarcoma	259	1.084	0.778	NS
SKCM	Skin Cutaneous Melanoma	459	1.101	0.615	NS
STAD	Stomach adenocarcinoma	388	0.837	0.44	NS
TGCT	Testicular Germ Cell Tumors	134	0	0.281	NS
THCA	Thyroid carcinoma	500	0.244	0.057	NS
THYM	Thymoma	119	0.605	0.621	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	0.629	0.103	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	0.038	0.44	NS
BRCA	Breast invasive carcinoma	1071	0.019	0.543	NS
CESC	Cervical and endocervical cancers	167	-0.098	0.208	NS
COAD	Colon adenocarcinoma	445	-0.015	0.746	NS
ESCA	Esophageal carcinoma	162	0.076	0.334	NS
HNSC	Head and Neck squamous cell carcinoma	448	-0.008	0.859	NS
KIRC	Kidney renal clear cell carcinoma	531	0.118	0.00651	Higher
KIRP	Kidney renal papillary cell carcinoma	260	0.224	0.000278	Higher
LIHC	Liver hepatocellular carcinoma	347	0.062	0.248	NS
LUAD	Lung adenocarcinoma	507	0.107	0.0156	Higher
LUSC	Lung squamous cell carcinoma	497	0.015	0.735	NS
OV	Ovarian serous cystadenocarcinoma	302	-0.031	0.591	NS
PAAD	Pancreatic adenocarcinoma	176	-0.062	0.413	NS
READ	Rectum adenocarcinoma	156	0.065	0.423	NS
SKCM	Skin Cutaneous Melanoma	410	-0.052	0.294	NS
STAD	Stomach adenocarcinoma	392	-0.07	0.166	NS
TGCT	Testicular Germ Cell Tumors	81	0.457	1.84e-05	Higher
THCA	Thyroid carcinoma	499	0.016	0.717	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	-0.138	0.00194	Lower

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	0.061	0.317	NS
HNSC	Head and Neck squamous cell carcinoma	498	0.208	2.86e-06	Higher
KIRC	Kidney renal clear cell carcinoma	525	0.096	0.0286	Higher
LGG	Brain Lower Grade Glioma	514	-0.081	0.0677	NS
LIHC	Liver hepatocellular carcinoma	366	0.154	0.00316	Higher
OV	Ovarian serous cystadenocarcinoma	296	0.136	0.0195	Higher
PAAD	Pancreatic adenocarcinoma	176	0.076	0.319	NS
STAD	Stomach adenocarcinoma	406	-0.016	0.749	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	-0.196	4.96e-06	Lower

Summary
Symbol	RBBP7
Name	RB binding protein 7, chromatin remodeling factor
Aliases	RbAp46; G1/S transition control protein-binding protein RbAp46; retinoblastoma-binding protein 7; retinoblas ......
Location	Xp22.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	RBBP7
Name	RB binding protein 7, chromatin remodeling factor
Aliases	RbAp46; G1/S transition control protein-binding protein RbAp46; retinoblastoma-binding protein 7; retinoblas ......
Location	Xp22.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for RBBP7.

Summary
Symbol	RBBP7
Name	RB binding protein 7, chromatin remodeling factor
Aliases	RbAp46; G1/S transition control protein-binding protein RbAp46; retinoblastoma-binding protein 7; retinoblas ......
Location	Xp22.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
25885317	Bladder Carcinoma	downstream	RECK	negative regulation	RbAp46 could bind with histone deacetylase (HDAC1) and Sp1, followed by binding to RECK promoter at the Sp1 site resulting in repression of RECK expression.