CR2Cancer

Summary
Symbol	RSF1
Name	remodeling and spacing factor 1
Aliases	XAP8; RSF-1; p325; HBXAP; hepatitis B virus x associated protein; HBV pX associated protein-8; HBV pX-associ ......
Location	11q14.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

[ TOP ]

Domain

PF00628 PHD-finger
PF15612 WSTF

Function

Required for assembly of regular nucleosome arrays by the RSF chromatin-remodeling complex (PubMed:12972596). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11944984, PubMed:11788598).

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification read	#	#	#	12972596

> Gene Ontology [ TOP ]
Biological Process	GO:0006323 DNA packaging GO:0006333 chromatin assembly or disassembly GO:0006334 nucleosome assembly GO:0006336 DNA replication-independent nucleosome assembly GO:0006338 chromatin remodeling GO:0006352 DNA-templated transcription, initiation GO:0016584 nucleosome positioning GO:0019058 viral life cycle GO:0019080 viral gene expression GO:0019083 viral transcription GO:0031055 chromatin remodeling at centromere GO:0031497 chromatin assembly GO:0034080 CENP-A containing nucleosome assembly GO:0034508 centromere complex assembly GO:0034724 DNA replication-independent nucleosome organization GO:0034728 nucleosome organization GO:0043044 ATP-dependent chromatin remodeling GO:0043392 negative regulation of DNA binding GO:0043486 histone exchange GO:0043900 regulation of multi-organism process GO:0043902 positive regulation of multi-organism process GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism GO:0044033 multi-organism metabolic process GO:0046782 regulation of viral transcription GO:0048524 positive regulation of viral process GO:0050434 positive regulation of viral transcription GO:0050792 regulation of viral process GO:0051098 regulation of binding GO:0051100 negative regulation of binding GO:0051101 regulation of DNA binding GO:0061641 CENP-A containing chromatin organization GO:0065004 protein-DNA complex assembly GO:0071103 DNA conformation change GO:0071824 protein-DNA complex subunit organization GO:1903900 regulation of viral life cycle GO:1903902 positive regulation of viral life cycle
Molecular Function	GO:0042393 histone binding
Cellular Component	GO:0031010 ISWI-type complex GO:0031213 RSF complex GO:0070603 SWI/SNF superfamily-type complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-1640170: Cell Cycle R-HSA-73886: Chromosome Maintenance R-HSA-606279: Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-774815: Nucleosome assembly

Summary
Symbol	RSF1
Name	remodeling and spacing factor 1
Aliases	XAP8; RSF-1; p325; HBXAP; hepatitis B virus x associated protein; HBV pX associated protein-8; HBV pX-associ ......
Location	11q14.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM1357130	c.603T>C	p.T201T	Substitution - coding silent	Large_intestine
COSM196570	c.3805C>T	p.R1269W	Substitution - Missense	Large_intestine
COSM4415873	c.3783T>C	p.D1261D	Substitution - coding silent	Skin
COSM3416255	c.216G>T	p.L72F	Substitution - Missense	Large_intestine
COSM4004513	c.3251G>A	p.R1084Q	Substitution - Missense	Ovary
COSM2019073	c.1446G>A	p.T482T	Substitution - coding silent	Large_intestine
COSM5673073	c.1306C>T	p.H436Y	Substitution - Missense	Soft_tissue
COSM3810476	c.3947G>C	p.G1316A	Substitution - Missense	Breast
COSM690576	c.1821A>G	p.P607P	Substitution - coding silent	Lung
COSM1663996	c.3658G>A	p.D1220N	Substitution - Missense	Kidney
COSM4768238	c.222G>A	p.L74L	Substitution - coding silent	Biliary_tract
COSM932190	c.4143G>A	p.E1381E	Substitution - coding silent	Endometrium
COSM429903	c.1989A>C	p.K663N	Substitution - Missense	Breast
COSM5623327	c.718G>T	p.E240*	Substitution - Nonsense	Oesophagus
COSM1357124	c.2199C>T	p.I733I	Substitution - coding silent	Large_intestine
COSM1224335	c.1786C>A	p.L596I	Substitution - Missense	Large_intestine
COSM932196	c.3156C>T	p.I1052I	Substitution - coding silent	Endometrium
COSM4491907	c.3884C>T	p.P1295L	Substitution - Missense	Skin
COSM1704418	c.1202G>A	p.G401E	Substitution - Missense	Skin
COSM196570	c.3805C>T	p.R1269W	Substitution - Missense	Endometrium
COSM1704418	c.1202G>A	p.G401E	Substitution - Missense	Liver
COSM4972516	c.787G>C	p.E263Q	Substitution - Missense	Oesophagus
COSM5927649	c.3336T>G	p.S1112R	Substitution - Missense	Skin
COSM3453564	c.306G>A	p.W102*	Substitution - Nonsense	Skin
COSM1746595	c.1509G>C	p.E503D	Substitution - Missense	Urinary_tract
COSM378980	c.822T>C	p.T274T	Substitution - coding silent	Lung
COSM1735411	c.2398delA	p.R800fs*24	Deletion - Frameshift	Stomach
COSM4798619	c.2712G>A	p.E904E	Substitution - coding silent	Liver
COSM3416254	c.262G>A	p.E88K	Substitution - Missense	Large_intestine
COSM690577	c.1992A>G	p.V664V	Substitution - coding silent	Lung
COSM3739301	c.3021G>T	p.L1007F	Substitution - Missense	Liver
COSM4036885	c.2143G>T	p.E715*	Substitution - Nonsense	Stomach
COSM4036888	c.1475C>A	p.S492Y	Substitution - Missense	Stomach
COSM4036877	c.3141C>T	p.G1047G	Substitution - coding silent	Stomach
COSM1605259	c.2334T>G	p.S778S	Substitution - coding silent	Liver
COSM5702177	c.2040_2041GG>TC	p.M680_D681>IH	Complex - compound substitution	Soft_tissue
COSM932199	c.2585G>A	p.S862N	Substitution - Missense	Endometrium
COSM1605260	c.1415A>G	p.Y472C	Substitution - Missense	Liver
COSM263463	c.3814C>T	p.R1272*	Substitution - Nonsense	Large_intestine
COSM1357118	c.3691C>T	p.R1231*	Substitution - Nonsense	Large_intestine
COSM2019052	c.2887C>T	p.R963C	Substitution - Missense	Large_intestine
COSM1224334	c.3124G>A	p.D1042N	Substitution - Missense	Large_intestine
COSM299484	c.267delA	p.K89fs*3	Deletion - Frameshift	Large_intestine
COSM5739392	c.268T>C	p.Y90H	Substitution - Missense	Small_intestine
COSM362862	c.3303T>A	p.D1101E	Substitution - Missense	Lung
COSM4036878	c.3129A>G	p.G1043G	Substitution - coding silent	Stomach
COSM5953346	c.1352T>C	p.V451A	Substitution - Missense	Oesophagus
COSM4036879	c.2994A>G	p.K998K	Substitution - coding silent	Stomach
COSM3453559	c.1364T>A	p.F455Y	Substitution - Missense	Soft_tissue
COSM5954763	c.1114G>A	p.E372K	Substitution - Missense	Upper_aerodigestive_tract
COSM247140	c.3967C>T	p.R1323C	Substitution - Missense	Prostate
COSM2019080	c.768G>T	p.E256D	Substitution - Missense	Large_intestine
COSM2019079	c.806A>G	p.N269S	Substitution - Missense	Central_nervous_system
COSM3953825	c.632C>A	p.P211H	Substitution - Missense	Lung
COSM1298644	c.2377G>A	p.D793N	Substitution - Missense	Urinary_tract
COSM3453556	c.1832C>T	p.P611L	Substitution - Missense	Skin
COSM3453546	c.3889C>T	p.R1297C	Substitution - Missense	Skin
COSM5428786	c.2088G>C	p.E696D	Substitution - Missense	Oesophagus
COSM3453548	c.3678C>T	p.S1226S	Substitution - coding silent	Skin
COSM690579	c.2813G>T	p.C938F	Substitution - Missense	Lung
COSM1676321	c.3643A>G	p.I1215V	Substitution - Missense	Skin
COSM5373651	c.1038G>A	p.Q346Q	Substitution - coding silent	Skin
COSM1663997	c.1111A>G	p.T371A	Substitution - Missense	Kidney
COSM3967850	c.3347A>G	p.Q1116R	Substitution - Missense	Central_nervous_system
COSM4454490	c.506A>G	p.Q169R	Substitution - Missense	Skin
COSM3368576	c.1430A>G	p.D477G	Substitution - Missense	Thyroid
COSM1638979	c.1158delA	p.K386fs*6	Deletion - Frameshift	Large_intestine
COSM196575	c.2530C>T	p.R844*	Substitution - Nonsense	Skin
COSM196570	c.3805C>T	p.R1269W	Substitution - Missense	Large_intestine
COSM3453555	c.2003C>T	p.T668I	Substitution - Missense	Skin
COSM5697745	c.2164A>G	p.T722A	Substitution - Missense	Soft_tissue
COSM5970389	c.3965C>T	p.A1322V	Substitution - Missense	Upper_aerodigestive_tract
COSM4400044	c.2398A>T	p.R800*	Substitution - Nonsense	Skin
COSM4927224	c.3849A>G	p.E1283E	Substitution - coding silent	Liver
COSM4849885	c.289G>C	p.E97Q	Substitution - Missense	Cervix
COSM932198	c.2829C>T	p.L943L	Substitution - coding silent	Endometrium
COSM5739390	c.3558C>A	p.D1186E	Substitution - Missense	Small_intestine
COSM213951	c.2908C>T	p.R970C	Substitution - Missense	Breast
COSM467449	c.1614A>C	p.E538D	Substitution - Missense	Kidney
COSM1628235	c.677A>G	p.E226G	Substitution - Missense	Liver
COSM932203	c.1608A>C	p.E536D	Substitution - Missense	Endometrium
COSM1357119	c.3624G>A	p.R1208R	Substitution - coding silent	Large_intestine
COSM932200	c.2552G>A	p.R851H	Substitution - Missense	Endometrium
COSM284709	c.3448C>T	p.R1150*	Substitution - Nonsense	Large_intestine
COSM1162976	c.1392T>C	p.F464F	Substitution - coding silent	Pancreas
COSM5016367	c.2475delA	p.K825fs*10	Deletion - Frameshift	Kidney
COSM314915	c.2587G>T	p.E863*	Substitution - Nonsense	Soft_tissue
COSM1704417	c.1606G>A	p.E536K	Substitution - Missense	Skin
COSM1728997	c.3656A>G	p.E1219G	Substitution - Missense	Liver
COSM4647467	c.3782A>G	p.D1261G	Substitution - Missense	Large_intestine
COSM1638979	c.1158delA	p.K386fs*6	Deletion - Frameshift	Stomach
COSM3453554	c.2621C>T	p.S874L	Substitution - Missense	Skin
COSM5687310	c.962C>T	p.P321L	Substitution - Missense	Soft_tissue
COSM196575	c.2530C>T	p.R844*	Substitution - Nonsense	Skin
COSM5602219	c.2246C>T	p.P749L	Substitution - Missense	Skin
COSM4998773	c.466C>T	p.R156*	Substitution - Nonsense	Pancreas
COSM5999588	c.3481C>T	p.R1161C	Substitution - Missense	Prostate
COSM4613277	c.1930delG	p.E644fs*5	Deletion - Frameshift	Large_intestine
COSM3453547	c.3827G>A	p.R1276Q	Substitution - Missense	Skin
COSM4647468	c.1083C>T	p.H361H	Substitution - coding silent	Large_intestine
COSM4036881	c.2598C>T	p.G866G	Substitution - coding silent	Stomach
COSM5999588	c.3481C>T	p.R1161C	Substitution - Missense	Prostate
COSM219710	c.3925_3927delGAG	p.E1309delE	Deletion - In frame	Breast
COSM932207	c.479G>A	p.G160D	Substitution - Missense	Endometrium
COSM231256	c.3458C>T	p.S1153F	Substitution - Missense	Skin
COSM5046522	c.313G>A	p.E105K	Substitution - Missense	Oesophagus
COSM5739391	c.840_841insA	p.E281fs*3	Insertion - Frameshift	Small_intestine
COSM5373650	c.2387C>T	p.A796V	Substitution - Missense	Skin
COSM2019037	c.3862G>A	p.E1288K	Substitution - Missense	Upper_aerodigestive_tract
COSM213881	c.3695G>A	p.R1232H	Substitution - Missense	Breast
COSM4415044	c.2679A>G	p.P893P	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM3810477	c.2775G>C	p.L925L	Substitution - coding silent	Breast
COSM1637080	c.3005A>T	p.K1002I	Substitution - Missense	Bone
COSM4036875	c.3398C>T	p.P1133L	Substitution - Missense	Stomach
COSM4036870	c.4205C>A	p.A1402E	Substitution - Missense	Stomach
COSM3359410	c.3919G>A	p.E1307K	Substitution - Missense	Kidney
COSM4757791	c.578+2T>C	p.?	Unknown	Stomach
COSM1357121	c.2988G>T	p.K996N	Substitution - Missense	Large_intestine
COSM4722919	c.2849A>G	p.Q950R	Substitution - Missense	Large_intestine
COSM40169	c.3519T>C	p.D1173D	Substitution - coding silent	Central_nervous_system
COSM1357126	c.1989_1990insA	p.V664fs*11	Insertion - Frameshift	Large_intestine
COSM1638979	c.1158delA	p.K386fs*6	Deletion - Frameshift	Stomach
COSM932202	c.1645G>T	p.D549Y	Substitution - Missense	Endometrium
COSM4036873	c.3437G>A	p.R1146H	Substitution - Missense	Stomach
COSM1605259	c.2334T>G	p.S778S	Substitution - coding silent	Liver
COSM4036880	c.2702A>C	p.N901T	Substitution - Missense	Stomach
COSM1605258	c.3016A>G	p.N1006D	Substitution - Missense	Liver
COSM932204	c.1451G>A	p.G484E	Substitution - Missense	Endometrium
COSM370724	c.3435C>T	p.S1145S	Substitution - coding silent	Lung
COSM5683520	c.3617G>T	p.R1206L	Substitution - Missense	Soft_tissue
COSM219710	c.3925_3927delGAG	p.E1309delE	Deletion - In frame	Breast
COSM4722921	c.1652C>G	p.S551C	Substitution - Missense	Large_intestine
COSM3453546	c.3889C>T	p.R1297C	Substitution - Missense	Skin
COSM3735426	c.2612C>T	p.S871F	Substitution - Missense	Skin
COSM3953824	c.1138G>T	p.A380S	Substitution - Missense	Lung
COSM4415873	c.3783T>C	p.D1261D	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM3453550	c.3158C>T	p.S1053F	Substitution - Missense	Skin
COSM3752752	c.1628C>T	p.S543F	Substitution - Missense	Large_intestine
COSM3453557	c.1743C>T	p.I581I	Substitution - coding silent	Skin
COSM1264619	c.2968delT	p.S990fs*30	Deletion - Frameshift	Oesophagus
COSM467448	c.1914T>A	p.C638*	Substitution - Nonsense	Kidney
COSM1746595	c.1509G>C	p.E503D	Substitution - Missense	Urinary_tract
COSM4401671	c.2158G>A	p.E720K	Substitution - Missense	Skin
COSM1704416	c.1612G>A	p.E538K	Substitution - Missense	Skin
COSM5962260	c.2224C>T	p.R742W	Substitution - Missense	Breast
COSM80471	c.378C>T	p.L126L	Substitution - coding silent	Ovary
COSM1605258	c.3016A>G	p.N1006D	Substitution - Missense	Liver
COSM3453560	c.1249G>A	p.E417K	Substitution - Missense	Skin
COSM5428097	c.279+8G>A	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM4036876	c.3223A>G	p.K1075E	Substitution - Missense	Stomach
COSM3453549	c.3192T>A	p.S1064S	Substitution - coding silent	Skin
COSM3453559	c.1364T>A	p.F455Y	Substitution - Missense	Skin
COSM3453553	c.2892C>T	p.A964A	Substitution - coding silent	Skin
COSM4574818	c.2537C>T	p.T846I	Substitution - Missense	Bone
COSM121775	c.3474G>A	p.Q1158Q	Substitution - coding silent	Upper_aerodigestive_tract
COSM1746594	c.2069G>A	p.G690D	Substitution - Missense	Urinary_tract
COSM3739300	c.3471G>T	p.R1157S	Substitution - Missense	Liver
COSM196575	c.2530C>T	p.R844*	Substitution - Nonsense	Skin
COSM4036872	c.3610C>T	p.R1204*	Substitution - Nonsense	Stomach
COSM5715132	c.4188C>A	p.D1396E	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3453547	c.3827G>A	p.R1276Q	Substitution - Missense	Lung
COSM4845211	c.3800C>G	p.S1267*	Substitution - Nonsense	Skin
COSM4826867	c.1429G>A	p.D477N	Substitution - Missense	Cervix
COSM2019080	c.768G>T	p.E256D	Substitution - Missense	Large_intestine
COSM1676322	c.2584A>T	p.S862C	Substitution - Missense	Large_intestine
COSM5811672	c.3996A>T	p.S1332S	Substitution - coding silent	Liver
COSM1605260	c.1415A>G	p.Y472C	Substitution - Missense	Liver
COSM4036884	c.2410G>A	p.E804K	Substitution - Missense	Stomach
COSM4036874	c.3436C>T	p.R1146C	Substitution - Missense	Stomach
COSM4617221	c.439G>A	p.D147N	Substitution - Missense	Large_intestine
COSM1735411	c.2398delA	p.R800fs*24	Deletion - Frameshift	Prostate
COSM4036886	c.2105A>G	p.Q702R	Substitution - Missense	Stomach
COSM3687657	c.10G>A	p.A4T	Substitution - Missense	Large_intestine
COSM4911081	c.1677C>A	p.T559T	Substitution - coding silent	Liver
COSM1735411	c.2398delA	p.R800fs*24	Deletion - Frameshift	Pancreas
COSM1638979	c.1158delA	p.K386fs*6	Deletion - Frameshift	Large_intestine
COSM4598309	c.2837A>G	p.K946R	Substitution - Missense	Upper_aerodigestive_tract
COSM3375957	c.1084G>A	p.E362K	Substitution - Missense	Pancreas
COSM4963170	c.273G>C	p.L91F	Substitution - Missense	Pancreas
COSM3453562	c.483C>A	p.L161L	Substitution - coding silent	Skin
COSM314915	c.2587G>T	p.E863*	Substitution - Nonsense	Lung
COSM1357125	c.2004C>A	p.T668T	Substitution - coding silent	Large_intestine
COSM4619974	c.1705A>C	p.K569Q	Substitution - Missense	Large_intestine
COSM932192	c.3820C>T	p.R1274W	Substitution - Missense	Endometrium
COSM4534314	c.2074G>A	p.E692K	Substitution - Missense	Skin
COSM1676322	c.2584A>T	p.S862C	Substitution - Missense	Large_intestine
COSM932191	c.3835G>T	p.D1279Y	Substitution - Missense	Endometrium
COSM5999588	c.3481C>T	p.R1161C	Substitution - Missense	Prostate
COSM1676322	c.2584A>T	p.S862C	Substitution - Missense	Large_intestine
COSM4979434	c.1242G>C	p.L414F	Substitution - Missense	Oesophagus
COSM932205	c.627T>C	p.I209I	Substitution - coding silent	Endometrium
COSM5048978	c.1172T>A	p.L391Q	Substitution - Missense	Oesophagus
COSM2019080	c.768G>T	p.E256D	Substitution - Missense	Large_intestine
COSM3453561	c.583C>T	p.R195*	Substitution - Nonsense	Skin
COSM147293	c.3900A>G	p.L1300L	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM5970390	c.2901A>G	p.R967R	Substitution - coding silent	Upper_aerodigestive_tract
COSM1638978	c.1980T>C	p.S660S	Substitution - coding silent	Stomach
COSM4036871	c.3940G>A	p.A1314T	Substitution - Missense	Stomach
COSM3710445	c.1773C>T	p.S591S	Substitution - coding silent	Upper_aerodigestive_tract
COSM2019071	c.1673C>T	p.S558F	Substitution - Missense	Skin
COSM3769454	c.112G>T	p.D38Y	Substitution - Missense	Pancreas
COSM467447	c.3984G>A	p.R1328R	Substitution - coding silent	Kidney
COSM5360570	c.1003G>C	p.D335H	Substitution - Missense	Large_intestine
COSM263463	c.3814C>T	p.R1272*	Substitution - Nonsense	Large_intestine
COSM196575	c.2530C>T	p.R844*	Substitution - Nonsense	Skin
COSM5361085	c.3269G>A	p.R1090Q	Substitution - Missense	Large_intestine
COSM5049339	c.751G>A	p.E251K	Substitution - Missense	Oesophagus
COSM1224333	c.4019C>T	p.P1340L	Substitution - Missense	Large_intestine
COSM1704416	c.1612G>A	p.E538K	Substitution - Missense	Skin
COSM1357128	c.1053C>T	p.I351I	Substitution - coding silent	Large_intestine
COSM241480	c.3607_3608insGGCGAA	p.R1206_S1207insRR	Insertion - In frame	Prostate
COSM5373652	c.942C>T	p.S314S	Substitution - coding silent	Skin
COSM1659280	c.2320A>G	p.T774A	Substitution - Missense	Kidney
COSM4641562	c.2506A>G	p.K836E	Substitution - Missense	Large_intestine
COSM213881	c.3695G>A	p.R1232H	Substitution - Missense	Biliary_tract
COSM932195	c.3263G>A	p.R1088H	Substitution - Missense	Endometrium
COSM4574819	c.1039G>A	p.E347K	Substitution - Missense	Bone
COSM1179724	c.2598C>A	p.G866G	Substitution - coding silent	Prostate
COSM1298643	c.4250C>G	p.A1417G	Substitution - Missense	Urinary_tract
COSM72499	c.4100A>G	p.D1367G	Substitution - Missense	Ovary
COSM1638979	c.1158delA	p.K386fs*6	Deletion - Frameshift	Large_intestine
COSM4467040	c.1467C>T	p.S489S	Substitution - coding silent	Skin
COSM5613457	c.1760A>T	p.K587M	Substitution - Missense	Lung
COSM690575	c.1783T>C	p.F595L	Substitution - Missense	Lung
COSM4798619	c.2712G>A	p.E904E	Substitution - coding silent	Liver
COSM932206	c.550G>T	p.D184Y	Substitution - Missense	Endometrium
COSM690581	c.3425A>G	p.D1142G	Substitution - Missense	Lung
COSM4474213	c.1902C>T	p.I634I	Substitution - coding silent	Skin
COSM196570	c.3805C>T	p.R1269W	Substitution - Missense	Large_intestine
COSM3416253	c.1648C>A	p.L550I	Substitution - Missense	Large_intestine
COSM3453563	c.481C>T	p.L161F	Substitution - Missense	Skin
COSM932193	c.3692G>A	p.R1231Q	Substitution - Missense	Endometrium
COSM3953823	c.4079C>A	p.P1360Q	Substitution - Missense	Lung
COSM5360570	c.1003G>C	p.D335H	Substitution - Missense	Large_intestine
COSM1264620	c.948G>T	p.K316N	Substitution - Missense	Stomach
COSM4722920	c.2536A>G	p.T846A	Substitution - Missense	Large_intestine
COSM4854718	c.579-1G>C	p.?	Unknown	Cervix
COSM3710445	c.1773C>T	p.S591S	Substitution - coding silent	Upper_aerodigestive_tract
COSM5051155	c.343A>C	p.S115R	Substitution - Missense	Stomach
COSM147293	c.3900A>G	p.L1300L	Substitution - coding silent	Stomach
COSM223482	c.847G>A	p.E283K	Substitution - Missense	Skin
COSM1746594	c.2069G>A	p.G690D	Substitution - Missense	Urinary_tract
COSM3453558	c.1404G>A	p.K468K	Substitution - coding silent	Skin
COSM5728840	c.1580C>T	p.A527V	Substitution - Missense	Skin
COSM4036889	c.1444A>C	p.T482P	Substitution - Missense	Stomach
COSM4845211	c.3800C>G	p.S1267*	Substitution - Nonsense	Cervix
COSM1357131	c.53G>A	p.G18D	Substitution - Missense	Large_intestine
COSM4427561	c.2209A>T	p.I737F	Substitution - Missense	Oesophagus
COSM1162975	c.3155T>A	p.I1052N	Substitution - Missense	Pancreas
COSM3375957	c.1084G>A	p.E362K	Substitution - Missense	Pancreas
COSM5810029	c.729A>T	p.K243N	Substitution - Missense	Liver
COSM2019071	c.1673C>T	p.S558F	Substitution - Missense	Skin
COSM386450	c.2558G>T	p.R853I	Substitution - Missense	Lung
COSM3375957	c.1084G>A	p.E362K	Substitution - Missense	Pancreas
COSM1735411	c.2398delA	p.R800fs*24	Deletion - Frameshift	Large_intestine
COSM4596859	c.3269G>T	p.R1090L	Substitution - Missense	Upper_aerodigestive_tract
COSM5477819	c.918G>A	p.K306K	Substitution - coding silent	Large_intestine
COSM196575	c.2530C>T	p.R844*	Substitution - Nonsense	Large_intestine
COSM3870259	c.2646T>A	p.S882R	Substitution - Missense	Skin
COSM1357122	c.2827C>T	p.L943F	Substitution - Missense	Large_intestine
COSM40170	c.749G>A	p.S250N	Substitution - Missense	Central_nervous_system
COSM932194	c.3488G>A	p.R1163Q	Substitution - Missense	Endometrium
COSM3931446	c.1377A>C	p.P459P	Substitution - coding silent	Urinary_tract
COSM4036887	c.1955G>A	p.S652N	Substitution - Missense	Stomach

> Text Mining based Variations [ TOP ]
There is no record for RSF1.

Summary
Symbol	RSF1
Name	remodeling and spacing factor 1
Aliases	XAP8; RSF-1; p325; HBXAP; hepatitis B virus x associated protein; HBV pX associated protein-8; HBV pX-associ ......
Location	11q14.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

[ TOP ]

Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
Q96T23	392	S	Phosphoserine	-	No	None detected
Q96T23	397	S	Phosphoserine	-	No	None detected
Q96T23	429	S	Phosphoserine	-	No	None detected
Q96T23	473	S	Phosphoserine	-	No	None detected
Q96T23	524	S	Phosphoserine	-	No	None detected
Q96T23	570	S	Phosphoserine	-	No	None detected
Q96T23	604	S	Phosphoserine	-	No	None detected
Q96T23	622	S	Phosphoserine	-	No	None detected
Q96T23	628	T	Phosphothreonine	-	No	None detected
Q96T23	629	S	Phosphoserine	-	No	None detected
Q96T23	748	S	Phosphoserine	-	No	None detected
Q96T23	882	S	Phosphoserine	-	Yes	p.S882R (cancer: SKCM)
Q96T23	1050	K	N6-acetyllysine	-	No	None detected
Q96T23	1096	S	Phosphoserine	-	No	None detected
Q96T23	1098	S	Phosphoserine	-	No	None detected
Q96T23	1105	S	Phosphoserine	-	No	None detected
Q96T23	1221	S	Phosphoserine	-	No	None detected
Q96T23	1223	S	Phosphoserine	-	No	None detected
Q96T23	1226	S	Phosphoserine	-	No	None detected
Q96T23	1258	S	Phosphoserine	-	No	None detected
Q96T23	1277	S	Phosphoserine	-	No	None detected
Q96T23	1278	T	Phosphothreonine	-	No	None detected
Q96T23	1305	T	Phosphothreonine	-	No	None detected
Q96T23	1325	S	Phosphoserine	-	No	None detected
Q96T23	1336	S	Phosphoserine	-	No	None detected
Q96T23	1339	K	N6-acetyllysine	-	No	None detected
Q96T23	1345	S	Phosphoserine	-	No	None detected
Q96T23	1359	S	Phosphoserine	-	No	None detected
Q96T23	1375	S	Phosphoserine	-	No	None detected

Summary
Symbol	RSF1
Name	remodeling and spacing factor 1
Aliases	XAP8; RSF-1; p325; HBXAP; hepatitis B virus x associated protein; HBV pX associated protein-8; HBV pX-associ ......
Location	11q14.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	5.347	4.703	-0.429	0.0123	NS
BRCA	Breast invasive carcinoma	112	1100	5.621	5.455	-0.067	0.466	NS
CESC	Cervical and endocervical cancers	3	306	5.227	4.69	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	4.682	4.546	-0.278	0.00996	NS
ESCA	Esophageal carcinoma	11	185	6.376	5.9	-0.347	0.0625	NS
GBM	Glioblastoma multiforme	5	166	5.211	4.727	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	4.652	4.755	0.126	0.33	NS
KIRC	Kidney renal clear cell carcinoma	72	534	5.405	5.095	-0.378	9.47e-08	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	4.977	4.358	-0.584	6.65e-05	Under
LAML	Acute Myeloid Leukemia	0	173	NA	6.495	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	5.74	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	3.659	3.293	-0.422	4.92e-05	NS
LUAD	Lung adenocarcinoma	59	517	5.082	5.049	0.068	0.457	NS
LUSC	Lung squamous cell carcinoma	51	501	5.025	5.018	0.049	0.608	NS
OV	Ovarian serous cystadenocarcinoma	0	307	NA	5.432	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	4.854	4.923	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	5.578	4.769	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	5.308	4.963	-0.357	7.1e-05	NS
READ	Rectum adenocarcinoma	10	167	4.757	4.483	-0.441	0.112	NS
SARC	Sarcoma	2	263	4.41	4.78	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	4.606	4.822	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	5.477	5.846	0.269	0.00551	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	4.767	NA	NA	NA
THCA	Thyroid carcinoma	59	509	5.462	5.23	-0.205	0.00866	NS
THYM	Thymoma	2	120	5.171	4.765	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	5.072	4.596	-0.481	5.09e-05	NS

> Cancer Cell Line Encyclopedia (CCLE)

[ TOP ]

Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	7.6
Autonomic ganglia	CHP212	8.1
Autonomic ganglia	IMR32	8.5
Autonomic ganglia	KELLY	8.5
Autonomic ganglia	KPNRTBM1	8.7
Autonomic ganglia	KPNSI9S	7.6
Autonomic ganglia	KPNYN	8.6
Autonomic ganglia	MHHNB11	8.7
Autonomic ganglia	NB1	9
Autonomic ganglia	NH6	8.2
Autonomic ganglia	SHSY5Y	9.2
Autonomic ganglia	SIMA	8.9
Autonomic ganglia	SKNAS	7.4
Autonomic ganglia	SKNBE2	8.8
Autonomic ganglia	SKNDZ	8.4
Autonomic ganglia	SKNFI	8
Autonomic ganglia	SKNSH	8
Biliary tract	HUCCT1	8
Biliary tract	HUH28	7.6
Biliary tract	SNU1079	9.6
Biliary tract	SNU1196	6.4
Biliary tract	SNU245	7
Biliary tract	SNU308	7.6
Biliary tract	SNU478	7.9
Bone	143B	7.8
Bone	A673	8.5
Bone	CADOES1	8.5
Bone	CAL78	6.8
Bone	G292CLONEA141B1	7.9
Bone	HOS	7.9
Bone	HS706T	7.3
Bone	HS737T	7.5
Bone	HS819T	7.4
Bone	HS821T	8.1
Bone	HS822T	7.8
Bone	HS863T	8.1
Bone	HS870T	7.3
Bone	HS888T	8.1
Bone	MG63	7.6
Bone	MHHES1	9.4
Bone	OUMS27	7.7
Bone	RDES	8.5
Bone	SJSA1	7
Bone	SKES1	8
Bone	SKNMC	8
Bone	SW1353	7.3
Bone	T173	7.4
Bone	TC71	7.6
Bone	U2OS	8.1
Breast	AU565	7.6
Breast	BT20	8.2
Breast	BT474	7.6
Breast	BT483	8.3
Breast	BT549	7.5
Breast	CAL120	8.5
Breast	CAL148	7.6
Breast	CAL51	8.6
Breast	CAL851	7.1
Breast	CAMA1	7
Breast	DU4475	7.7
Breast	EFM192A	7.2
Breast	EFM19	7.6
Breast	EVSAT	7.6
Breast	HCC1143	8.4
Breast	HCC1187	8.8
Breast	HCC1395	6.9
Breast	HCC1419	7.7
Breast	HCC1428	8.4
Breast	HCC1500	8.6
Breast	HCC1569	8.2
Breast	HCC1599	7.3
Breast	HCC1806	8.7
Breast	HCC1937	8
Breast	HCC1954	8
Breast	HCC202	7.7
Breast	HCC2157	7.6
Breast	HCC2218	7.5
Breast	HCC38	8.1
Breast	HCC70	7.9
Breast	HDQP1	7.7
Breast	HMC18	8.4
Breast	HS274T	8.3
Breast	HS281T	8
Breast	HS343T	8
Breast	HS578T	8
Breast	HS606T	7.4
Breast	HS739T	7.5
Breast	HS742T	7.8
Breast	JIMT1	7.8
Breast	KPL1	8.4
Breast	MCF7	8.1
Breast	MDAMB134VI	11.1
Breast	MDAMB157	7.4
Breast	MDAMB175VII	9.1
Breast	MDAMB231	7.9
Breast	MDAMB361	7.4
Breast	MDAMB415	6.7
Breast	MDAMB436	7
Breast	MDAMB453	8.8
Breast	MDAMB468	8.3
Breast	SKBR3	7.6
Breast	T47D	7.8
Breast	UACC812	7.8
Breast	UACC893	7.8
Breast	YMB1	7.2
Breast	ZR751	7.7
Breast	ZR7530	7.5
Central nervous system	1321N1	7.8
Central nervous system	42MGBA	8.4
Central nervous system	8MGBA	8.5
Central nervous system	A172	8.1
Central nervous system	AM38	7.6
Central nervous system	BECKER	7.6
Central nervous system	CAS1	7.8
Central nervous system	CCFSTTG1	7.8
Central nervous system	D283MED	8.1
Central nervous system	D341MED	8.7
Central nervous system	DAOY	7.6
Central nervous system	DBTRG05MG	8
Central nervous system	DKMG	8.4
Central nervous system	GAMG	7.8
Central nervous system	GB1	7.3
Central nervous system	GI1	7.9
Central nervous system	GMS10	8.2
Central nervous system	GOS3	8.2
Central nervous system	H4	7.5
Central nervous system	HS683	7.9
Central nervous system	KALS1	7.3
Central nervous system	KG1C	7.7
Central nervous system	KNS42	8.2
Central nervous system	KNS60	7.8
Central nervous system	KNS81	7.9
Central nervous system	KS1	7.9
Central nervous system	LN18	8.3
Central nervous system	LN229	8.3
Central nervous system	M059K	7.9
Central nervous system	MOGGCCM	7.5
Central nervous system	MOGGUVW	7.6
Central nervous system	NMCG1	7.4
Central nervous system	ONS76	8.1
Central nervous system	SF126	8
Central nervous system	SF295	7
Central nervous system	SNB19	7.5
Central nervous system	SNU1105	7.4
Central nervous system	SNU201	7.3
Central nervous system	SNU466	6.8
Central nervous system	SNU489	6.8
Central nervous system	SNU626	7.7
Central nervous system	SNU738	7.3
Central nervous system	SW1088	7.5
Central nervous system	SW1783	7.4
Central nervous system	T98G	8
Central nervous system	TM31	8.5
Central nervous system	U118MG	7.8
Central nervous system	U138MG	8.2
Central nervous system	U251MG	7.1
Central nervous system	U87MG	6.7
Central nervous system	YH13	7.9
Central nervous system	YKG1	7.6
Endometrium	AN3CA	7.7
Endometrium	COLO684	7.3
Endometrium	EFE184	7.6
Endometrium	EN	8.6
Endometrium	ESS1	8.1
Endometrium	HEC108	8.2
Endometrium	HEC151	7.6
Endometrium	HEC1A	8
Endometrium	HEC1B	8.1
Endometrium	HEC251	8
Endometrium	HEC265	7.6
Endometrium	HEC50B	8
Endometrium	HEC59	7.7
Endometrium	HEC6	8.1
Endometrium	ISHIKAWAHERAKLIO02ER	7.8
Endometrium	JHUEM1	7.6
Endometrium	JHUEM2	8.1
Endometrium	JHUEM3	11.1
Endometrium	KLE	6.6
Endometrium	MFE280	7.9
Endometrium	MFE296	7.9
Endometrium	MFE319	7.7
Endometrium	RL952	7.9
Endometrium	SNGM	8
Endometrium	SNU1077	8.7
Endometrium	SNU685	7.7
Endometrium	TEN	8
Haematopoietic and lymphoid	697	8.2
Haematopoietic and lymphoid	A3KAW	7.7
Haematopoietic and lymphoid	A4FUK	7.7
Haematopoietic and lymphoid	ALLSIL	8.1
Haematopoietic and lymphoid	AML193	7.8
Haematopoietic and lymphoid	AMO1	7.5
Haematopoietic and lymphoid	BCP1	6.4
Haematopoietic and lymphoid	BDCM	7.8
Haematopoietic and lymphoid	BL41	8.1
Haematopoietic and lymphoid	BL70	7.9
Haematopoietic and lymphoid	BV173	8.5
Haematopoietic and lymphoid	CA46	8.2
Haematopoietic and lymphoid	CI1	8.1
Haematopoietic and lymphoid	CMK115	8.7
Haematopoietic and lymphoid	CMK86	8.2
Haematopoietic and lymphoid	CMK	8.5
Haematopoietic and lymphoid	CMLT1	8
Haematopoietic and lymphoid	COLO775	7.2
Haematopoietic and lymphoid	DAUDI	8.1
Haematopoietic and lymphoid	DB	8.6
Haematopoietic and lymphoid	DEL	8
Haematopoietic and lymphoid	DND41	7.4
Haematopoietic and lymphoid	DOHH2	7.9
Haematopoietic and lymphoid	EB1	8.3
Haematopoietic and lymphoid	EB2	8
Haematopoietic and lymphoid	EHEB	7.8
Haematopoietic and lymphoid	EJM	8.1
Haematopoietic and lymphoid	EM2	8.5
Haematopoietic and lymphoid	EOL1	7.5
Haematopoietic and lymphoid	F36P	8
Haematopoietic and lymphoid	GA10	7.8
Haematopoietic and lymphoid	GDM1	7.9
Haematopoietic and lymphoid	GRANTA519	7.8
Haematopoietic and lymphoid	HDLM2	7.4
Haematopoietic and lymphoid	HDMYZ	8
Haematopoietic and lymphoid	HEL9217	7.9
Haematopoietic and lymphoid	HEL	7.9
Haematopoietic and lymphoid	HH	7.6
Haematopoietic and lymphoid	HL60	8.6
Haematopoietic and lymphoid	HPBALL	7.5
Haematopoietic and lymphoid	HS604T	7.8
Haematopoietic and lymphoid	HS611T	7.7
Haematopoietic and lymphoid	HS616T	7.9
Haematopoietic and lymphoid	HS751T	7.9
Haematopoietic and lymphoid	HT	7.7
Haematopoietic and lymphoid	HTK	7.1
Haematopoietic and lymphoid	HUNS1	7.5
Haematopoietic and lymphoid	HUT102	7.7
Haematopoietic and lymphoid	HUT78	7.7
Haematopoietic and lymphoid	JEKO1	8
Haematopoietic and lymphoid	JK1	7.6
Haematopoietic and lymphoid	JM1	7.5
Haematopoietic and lymphoid	JURKAT	7.8
Haematopoietic and lymphoid	JURLMK1	7.7
Haematopoietic and lymphoid	JVM2	8.2
Haematopoietic and lymphoid	JVM3	8.2
Haematopoietic and lymphoid	K562	7.7
Haematopoietic and lymphoid	KARPAS299	7.6
Haematopoietic and lymphoid	KARPAS422	8.3
Haematopoietic and lymphoid	KARPAS620	8.7
Haematopoietic and lymphoid	KASUMI1	8.7
Haematopoietic and lymphoid	KASUMI2	7.2
Haematopoietic and lymphoid	KASUMI6	7.8
Haematopoietic and lymphoid	KCL22	8.1
Haematopoietic and lymphoid	KE37	7.5
Haematopoietic and lymphoid	KE97	7.4
Haematopoietic and lymphoid	KG1	8.8
Haematopoietic and lymphoid	KHM1B	7.8
Haematopoietic and lymphoid	KIJK	7.3
Haematopoietic and lymphoid	KMH2	8
Haematopoietic and lymphoid	KMM1	7.3
Haematopoietic and lymphoid	KMS11	8.1
Haematopoietic and lymphoid	KMS12BM	8.6
Haematopoietic and lymphoid	KMS18	8
Haematopoietic and lymphoid	KMS20	7.1
Haematopoietic and lymphoid	KMS21BM	7.5
Haematopoietic and lymphoid	KMS26	7.9
Haematopoietic and lymphoid	KMS27	7.8
Haematopoietic and lymphoid	KMS28BM	8.3
Haematopoietic and lymphoid	KMS34	7.9
Haematopoietic and lymphoid	KO52	8.2
Haematopoietic and lymphoid	KOPN8	7
Haematopoietic and lymphoid	KU812	8.9
Haematopoietic and lymphoid	KYO1	7.9
Haematopoietic and lymphoid	L1236	7.8
Haematopoietic and lymphoid	L363	8.7
Haematopoietic and lymphoid	L428	7.7
Haematopoietic and lymphoid	L540	7.7
Haematopoietic and lymphoid	LAMA84	8.2
Haematopoietic and lymphoid	LOUCY	8.4
Haematopoietic and lymphoid	LP1	7.3
Haematopoietic and lymphoid	M07E	8.6
Haematopoietic and lymphoid	MC116	7.8
Haematopoietic and lymphoid	ME1	7.5
Haematopoietic and lymphoid	MEC1	8.9
Haematopoietic and lymphoid	MEC2	8.6
Haematopoietic and lymphoid	MEG01	8.4
Haematopoietic and lymphoid	MHHCALL2	8.4
Haematopoietic and lymphoid	MHHCALL3	7.8
Haematopoietic and lymphoid	MHHCALL4	8.2
Haematopoietic and lymphoid	MINO	7.8
Haematopoietic and lymphoid	MJ	7.6
Haematopoietic and lymphoid	MM1S	7.8
Haematopoietic and lymphoid	MOLM13	7.7
Haematopoietic and lymphoid	MOLM16	8.5
Haematopoietic and lymphoid	MOLM6	7.3
Haematopoietic and lymphoid	MOLP2	7.4
Haematopoietic and lymphoid	MOLP8	8
Haematopoietic and lymphoid	MOLT13	8.3
Haematopoietic and lymphoid	MOLT16	8.2
Haematopoietic and lymphoid	MOLT4	8
Haematopoietic and lymphoid	MONOMAC1	7.6
Haematopoietic and lymphoid	MONOMAC6	8
Haematopoietic and lymphoid	MOTN1	7.1
Haematopoietic and lymphoid	MUTZ5	7.8
Haematopoietic and lymphoid	MV411	8
Haematopoietic and lymphoid	NALM19	7.4
Haematopoietic and lymphoid	NALM1	7.8
Haematopoietic and lymphoid	NALM6	7.8
Haematopoietic and lymphoid	NAMALWA	8.4
Haematopoietic and lymphoid	NB4	8.8
Haematopoietic and lymphoid	NCIH929	7.3
Haematopoietic and lymphoid	NCO2	9.1
Haematopoietic and lymphoid	NOMO1	8.3
Haematopoietic and lymphoid	NUDHL1	7
Haematopoietic and lymphoid	NUDUL1	8.5
Haematopoietic and lymphoid	OCIAML2	7.7
Haematopoietic and lymphoid	OCIAML3	7.7
Haematopoietic and lymphoid	OCIAML5	7.4
Haematopoietic and lymphoid	OCILY10	7.9
Haematopoietic and lymphoid	OCILY19	8
Haematopoietic and lymphoid	OCILY3	8.3
Haematopoietic and lymphoid	OCIM1	10.4
Haematopoietic and lymphoid	OPM2	9.1
Haematopoietic and lymphoid	P12ICHIKAWA	8.7
Haematopoietic and lymphoid	P31FUJ	7.6
Haematopoietic and lymphoid	P3HR1	7.9
Haematopoietic and lymphoid	PCM6	7.2
Haematopoietic and lymphoid	PEER	8.1
Haematopoietic and lymphoid	PF382	8
Haematopoietic and lymphoid	PFEIFFER	8.8
Haematopoietic and lymphoid	PL21	7.2
Haematopoietic and lymphoid	RAJI	7.6
Haematopoietic and lymphoid	RCHACV	8.1
Haematopoietic and lymphoid	REC1	8.8
Haematopoietic and lymphoid	REH	8.4
Haematopoietic and lymphoid	RI1	6.7
Haematopoietic and lymphoid	RL	8.7
Haematopoietic and lymphoid	RPMI8226	8.2
Haematopoietic and lymphoid	RPMI8402	8.4
Haematopoietic and lymphoid	RS411	8
Haematopoietic and lymphoid	SEM	8
Haematopoietic and lymphoid	SET2	8.4
Haematopoietic and lymphoid	SIGM5	8.2
Haematopoietic and lymphoid	SKM1	7.9
Haematopoietic and lymphoid	SKMM2	8.1
Haematopoietic and lymphoid	SR786	8.1
Haematopoietic and lymphoid	ST486	7.9
Haematopoietic and lymphoid	SUDHL10	7.3
Haematopoietic and lymphoid	SUDHL1	7.8
Haematopoietic and lymphoid	SUDHL4	7.2
Haematopoietic and lymphoid	SUDHL5	8.1
Haematopoietic and lymphoid	SUDHL6	8.6
Haematopoietic and lymphoid	SUDHL8	8.3
Haematopoietic and lymphoid	SUPB15	7.7
Haematopoietic and lymphoid	SUPHD1	7.4
Haematopoietic and lymphoid	SUPM2	8.1
Haematopoietic and lymphoid	SUPT11	8.3
Haematopoietic and lymphoid	SUPT1	7.8
Haematopoietic and lymphoid	TALL1	8.7
Haematopoietic and lymphoid	TF1	8.3
Haematopoietic and lymphoid	THP1	8
Haematopoietic and lymphoid	TO175T	7.7
Haematopoietic and lymphoid	TOLEDO	8.6
Haematopoietic and lymphoid	U266B1	7.5
Haematopoietic and lymphoid	U937	7.9
Haematopoietic and lymphoid	UT7	8.5
Haematopoietic and lymphoid	WSUDLCL2	8.2
Kidney	769P	8
Kidney	786O	7.2
Kidney	A498	6.8
Kidney	A704	7.5
Kidney	ACHN	6.7
Kidney	BFTC909	7.8
Kidney	CAKI1	8.1
Kidney	CAKI2	6.7
Kidney	CAL54	7
Kidney	KMRC1	8.1
Kidney	KMRC20	7.7
Kidney	KMRC2	7.6
Kidney	KMRC3	8.1
Kidney	OSRC2	7.8
Kidney	RCC10RGB	8.3
Kidney	SNU1272	7.8
Kidney	SNU349	6.7
Kidney	TUHR10TKB	7.4
Kidney	TUHR14TKB	7.9
Kidney	TUHR4TKB	7.4
Kidney	VMRCRCW	7.6
Kidney	VMRCRCZ	8.2
Large intestine	C2BBE1	8.2
Large intestine	CCK81	7.9
Large intestine	CL11	8.1
Large intestine	CL14	7.7
Large intestine	CL34	7.6
Large intestine	CL40	6.7
Large intestine	COLO205	7
Large intestine	COLO320	8.4
Large intestine	COLO678	8.4
Large intestine	CW2	7.6
Large intestine	DLD1	8
Large intestine	GP2D	8
Large intestine	HCC56	7.3
Large intestine	HCT116	7.7
Large intestine	HCT15	7.9
Large intestine	HS675T	7.5
Large intestine	HS698T	7.2
Large intestine	HT115	7.8
Large intestine	HT29	8.3
Large intestine	HT55	8.1
Large intestine	KM12	7.8
Large intestine	LOVO	7.5
Large intestine	LS1034	7.9
Large intestine	LS123	9
Large intestine	LS180	7.6
Large intestine	LS411N	8.1
Large intestine	LS513	7.6
Large intestine	MDST8	7.5
Large intestine	NCIH508	7.8
Large intestine	NCIH716	7.4
Large intestine	NCIH747	8.5
Large intestine	OUMS23	8
Large intestine	RCM1	7.5
Large intestine	RKO	7.6
Large intestine	SKCO1	7.9
Large intestine	SNU1040	7.2
Large intestine	SNU1197	7.9
Large intestine	SNU175	8.1
Large intestine	SNU283	7.1
Large intestine	SNU407	8
Large intestine	SNU503	7.7
Large intestine	SNU61	7.8
Large intestine	SNU81	7.1
Large intestine	SNUC1	6.9
Large intestine	SNUC2A	8.2
Large intestine	SNUC4	7.2
Large intestine	SNUC5	8.1
Large intestine	SW1116	7.7
Large intestine	SW1417	7.8
Large intestine	SW1463	7.8
Large intestine	SW403	7.7
Large intestine	SW480	8
Large intestine	SW48	7.8
Large intestine	SW620	8.1
Large intestine	SW837	8.7
Large intestine	SW948	7.7
Large intestine	T84	7.8
Liver	ALEXANDERCELLS	7.7
Liver	C3A	7.2
Liver	HEP3B217	7.5
Liver	HEPG2	7.4
Liver	HLE	8.3
Liver	HLF	8
Liver	HUH1	7.2
Liver	HUH6	7.1
Liver	HUH7	7.4
Liver	JHH1	8.2
Liver	JHH2	7.8
Liver	JHH4	8.5
Liver	JHH5	8.3
Liver	JHH6	8.1
Liver	JHH7	7.8
Liver	LI7	7.7
Liver	PLCPRF5	7.6
Liver	SKHEP1	7.9
Liver	SNU182	7.8
Liver	SNU387	7.9
Liver	SNU398	8.2
Liver	SNU423	7.8
Liver	SNU449	7.5
Liver	SNU475	7.8
Liver	SNU761	8.4
Liver	SNU878	6.4
Liver	SNU886	6.5
Lung	A549	7.6
Lung	ABC1	7.7
Lung	BEN	8.2
Lung	CAL12T	7.4
Lung	CALU1	7.8
Lung	CALU3	8.4
Lung	CALU6	8.4
Lung	CHAGOK1	7.8
Lung	COLO668	7.4
Lung	COLO699	7.5
Lung	CORL105	7.9
Lung	CORL23	8.7
Lung	CORL24	9
Lung	CORL279	8.3
Lung	CORL311	8.8
Lung	CORL47	8.1
Lung	CORL51	8.9
Lung	CORL88	8.7
Lung	CORL95	8.5
Lung	CPCN	8.1
Lung	DMS114	8
Lung	DMS153	8.6
Lung	DMS273	7.4
Lung	DMS454	7.9
Lung	DMS53	8.6
Lung	DMS79	9
Lung	DV90	7.7
Lung	EBC1	8.1
Lung	EPLC272H	8.3
Lung	HARA	7
Lung	HCC1171	8.1
Lung	HCC1195	7.8
Lung	HCC15	7.8
Lung	HCC2279	7.8
Lung	HCC2935	8.5
Lung	HCC33	9
Lung	HCC366	9.3
Lung	HCC4006	8.8
Lung	HCC44	7.7
Lung	HCC78	8.2
Lung	HCC827	7.9
Lung	HCC95	7.4
Lung	HLC1	7.4
Lung	HLFA	7.9
Lung	HS229T	7.6
Lung	HS618T	7.5
Lung	IALM	8.5
Lung	KNS62	7
Lung	LC1F	8.1
Lung	LC1SQSF	7.8
Lung	LCLC103H	7.9
Lung	LCLC97TM1	8.3
Lung	LK2	8
Lung	LOUNH91	7.6
Lung	LU65	7.4
Lung	LU99	7.6
Lung	LUDLU1	7.8
Lung	LXF289	7.4
Lung	MORCPR	7.5
Lung	NCIH1048	8.2
Lung	NCIH1092	9.5
Lung	NCIH1105	9
Lung	NCIH1155	8.1
Lung	NCIH1184	8.7
Lung	NCIH1299	7.8
Lung	NCIH1339	8.4
Lung	NCIH1341	7.5
Lung	NCIH1355	7.6
Lung	NCIH1373	8.1
Lung	NCIH1385	7.4
Lung	NCIH1395	8.5
Lung	NCIH1435	11
Lung	NCIH1436	9
Lung	NCIH1437	7.5
Lung	NCIH146	7.6
Lung	NCIH1563	7.4
Lung	NCIH1568	7.8
Lung	NCIH1573	7.9
Lung	NCIH1581	8.6
Lung	NCIH1618	9.2
Lung	NCIH1623	7.4
Lung	NCIH1648	8.4
Lung	NCIH1650	8.1
Lung	NCIH1651	7.6
Lung	NCIH1666	7.2
Lung	NCIH1693	8.5
Lung	NCIH1694	8.1
Lung	NCIH1703	8.2
Lung	NCIH1734	8
Lung	NCIH1755	7.5
Lung	NCIH1781	8.3
Lung	NCIH1792	6.9
Lung	NCIH1793	7.3
Lung	NCIH1836	8.3
Lung	NCIH1838	7.8
Lung	NCIH1869	8.1
Lung	NCIH1876	9.2
Lung	NCIH1915	8.4
Lung	NCIH1930	7.9
Lung	NCIH1944	6.8
Lung	NCIH1963	9.1
Lung	NCIH196	8
Lung	NCIH1975	7.9
Lung	NCIH2009	8.6
Lung	NCIH2023	7.3
Lung	NCIH2029	8.3
Lung	NCIH2030	7.9
Lung	NCIH2066	7.6
Lung	NCIH2081	8.9
Lung	NCIH2085	7.8
Lung	NCIH2087	8.1
Lung	NCIH209	8.5
Lung	NCIH2106	6.4
Lung	NCIH2110	8.6
Lung	NCIH211	8.9
Lung	NCIH2122	6.9
Lung	NCIH2126	7.7
Lung	NCIH2141	8.7
Lung	NCIH2170	7.5
Lung	NCIH2171	9.4
Lung	NCIH2172	7.8
Lung	NCIH2196	8.7
Lung	NCIH2227	8.5
Lung	NCIH2228	7.9
Lung	NCIH226	8
Lung	NCIH2286	8.6
Lung	NCIH2291	7.4
Lung	NCIH2342	8.3
Lung	NCIH2347	7.6
Lung	NCIH23	8.8
Lung	NCIH2405	8.4
Lung	NCIH2444	7.4
Lung	NCIH292	7.8
Lung	NCIH322	8.8
Lung	NCIH3255	7.7
Lung	NCIH358	8.6
Lung	NCIH441	9.3
Lung	NCIH446	8.9
Lung	NCIH460	6.9
Lung	NCIH510	8.1
Lung	NCIH520	8.4
Lung	NCIH522	8.4
Lung	NCIH524	8.1
Lung	NCIH526	8.4
Lung	NCIH596	8.5
Lung	NCIH647	7.7
Lung	NCIH650	9.4
Lung	NCIH661	8.1
Lung	NCIH69	7.8
Lung	NCIH727	9.1
Lung	NCIH810	8.2
Lung	NCIH82	7.9
Lung	NCIH838	8.7
Lung	NCIH841	9.1
Lung	NCIH854	8.2
Lung	NCIH889	8.6
Lung	PC14	8.7
Lung	RERFLCAD1	8.8
Lung	RERFLCAD2	9.2
Lung	RERFLCAI	7.9
Lung	RERFLCKJ	7.9
Lung	RERFLCMS	7.5
Lung	RERFLCSQ1	7.9
Lung	SBC5	7.8
Lung	SCLC21H	9.3
Lung	SHP77	8.5
Lung	SKLU1	8.1
Lung	SKMES1	8.4
Lung	SQ1	8
Lung	SW1271	8.5
Lung	SW1573	7.8
Lung	SW900	8.5
Lung	VMRCLCD	7.5
Lung	VMRCLCP	7.8
Oesophagus	COLO680N	8.5
Oesophagus	ECGI10	8.1
Oesophagus	KYSE140	8.8
Oesophagus	KYSE150	8.3
Oesophagus	KYSE180	8.1
Oesophagus	KYSE270	7.6
Oesophagus	KYSE30	8.4
Oesophagus	KYSE410	8
Oesophagus	KYSE450	8.8
Oesophagus	KYSE510	7.9
Oesophagus	KYSE520	8.3
Oesophagus	KYSE70	7.8
Oesophagus	OE19	8.6
Oesophagus	OE33	8.7
Oesophagus	TE10	7.2
Oesophagus	TE11	7.8
Oesophagus	TE14	8.1
Oesophagus	TE15	9.3
Oesophagus	TE1	8.1
Oesophagus	TE4	8.4
Oesophagus	TE5	6.3
Oesophagus	TE6	7.7
Oesophagus	TE8	8
Oesophagus	TE9	6.7
Oesophagus	TT	7.6
Ovary	59M	7.4
Ovary	A2780	8.9
Ovary	CAOV3	8
Ovary	CAOV4	7.6
Ovary	COLO704	8
Ovary	COV318	8.4
Ovary	COV362	9
Ovary	COV434	8.7
Ovary	COV504	7.7
Ovary	COV644	7.8
Ovary	EFO21	8.2
Ovary	EFO27	7.8
Ovary	ES2	7.7
Ovary	FUOV1	8.1
Ovary	HEYA8	8.8
Ovary	HS571T	7.6
Ovary	IGROV1	7.7
Ovary	JHOC5	8.1
Ovary	JHOM1	7.8
Ovary	JHOM2B	8.2
Ovary	JHOS2	8.3
Ovary	JHOS4	8.8
Ovary	KURAMOCHI	8.4
Ovary	MCAS	7.8
Ovary	NIHOVCAR3	11
Ovary	OAW28	8.4
Ovary	OAW42	6.9
Ovary	OC314	7.4
Ovary	OC316	7.4
Ovary	ONCODG1	10.7
Ovary	OV56	8
Ovary	OV7	7.4
Ovary	OV90	8.2
Ovary	OVCAR4	7.6
Ovary	OVCAR8	8.4
Ovary	OVISE	7.2
Ovary	OVK18	7
Ovary	OVKATE	8.9
Ovary	OVMANA	8.1
Ovary	OVSAHO	8
Ovary	OVTOKO	8.4
Ovary	RMGI	6.8
Ovary	RMUGS	6.9
Ovary	SKOV3	7.6
Ovary	SNU119	8.3
Ovary	SNU840	7.7
Ovary	SNU8	7.6
Ovary	TOV112D	7.9
Ovary	TOV21G	8.1
Ovary	TYKNU	8.4
Pancreas	ASPC1	8.3
Pancreas	BXPC3	7.6
Pancreas	CAPAN1	8.2
Pancreas	CAPAN2	8.2
Pancreas	CFPAC1	8.4
Pancreas	DANG	8.5
Pancreas	HPAC	8
Pancreas	HPAFII	7.9
Pancreas	HS766T	7.7
Pancreas	HUPT3	8
Pancreas	HUPT4	8.3
Pancreas	KCIMOH1	8.2
Pancreas	KLM1	6.4
Pancreas	KP2	8.7
Pancreas	KP3	8.4
Pancreas	KP4	8.6
Pancreas	L33	8.4
Pancreas	MIAPACA2	8.5
Pancreas	PANC0203	8.7
Pancreas	PANC0213	8.2
Pancreas	PANC0327	8.2
Pancreas	PANC0403	8.2
Pancreas	PANC0504	7.5
Pancreas	PANC0813	8.4
Pancreas	PANC1005	8.4
Pancreas	PANC1	8.3
Pancreas	PATU8902	8.9
Pancreas	PATU8988S	8
Pancreas	PATU8988T	7.9
Pancreas	PK1	7.6
Pancreas	PK45H	8
Pancreas	PK59	7.5
Pancreas	PL45	8.3
Pancreas	PSN1	7.9
Pancreas	QGP1	8.8
Pancreas	SNU213	8.6
Pancreas	SNU324	7.7
Pancreas	SNU410	7.4
Pancreas	SU8686	8.3
Pancreas	SUIT2	8.6
Pancreas	SW1990	8.1
Pancreas	T3M4	8.4
Pancreas	TCCPAN2	7.2
Pancreas	YAPC	8.7
Pleura	ACCMESO1	7
Pleura	DM3	7.1
Pleura	ISTMES1	7.9
Pleura	ISTMES2	8
Pleura	JL1	7.8
Pleura	MPP89	6.7
Pleura	MSTO211H	7.8
Pleura	NCIH2052	7.8
Pleura	NCIH2452	7.8
Pleura	NCIH28	7.4
Prostate	22RV1	6.5
Prostate	DU145	7.9
Prostate	LNCAPCLONEFGC	8.1
Prostate	MDAPCA2B	7.7
Prostate	NCIH660	8.1
Prostate	PC3	7.4
Prostate	VCAP	7.9
Salivary gland	A253	7.3
Salivary gland	YD15	8.3
Skin	A101D	6.7
Skin	A2058	6.9
Skin	A375	7.7
Skin	C32	7.9
Skin	CHL1	8
Skin	CJM	7.8
Skin	COLO679	7.7
Skin	COLO741	7.6
Skin	COLO783	8.1
Skin	COLO792	5.8
Skin	COLO800	7.6
Skin	COLO818	7.6
Skin	COLO829	7.9
Skin	COLO849	7.8
Skin	G361	7.6
Skin	GRM	7.1
Skin	HMCB	7.8
Skin	HS294T	7.2
Skin	HS600T	7.6
Skin	HS688AT	7.6
Skin	HS695T	7.5
Skin	HS839T	7.3
Skin	HS852T	10.3
Skin	HS895T	7.8
Skin	HS934T	7.8
Skin	HS936T	6.4
Skin	HS939T	7.4
Skin	HS940T	7.8
Skin	HS944T	6.6
Skin	HT144	7.1
Skin	IGR1	7
Skin	IGR37	6.4
Skin	IGR39	7.7
Skin	IPC298	7.6
Skin	K029AX	7.2
Skin	LOXIMVI	8.2
Skin	MALME3M	6.6
Skin	MDAMB435S	8.3
Skin	MELHO	6.7
Skin	MELJUSO	7.2
Skin	MEWO	9.1
Skin	RPMI7951	8.1
Skin	RVH421	8.4
Skin	SH4	7.4
Skin	SKMEL1	7.4
Skin	SKMEL24	7.5
Skin	SKMEL28	6.9
Skin	SKMEL2	6.2
Skin	SKMEL30	7.1
Skin	SKMEL31	7.4
Skin	SKMEL3	8.1
Skin	SKMEL5	6.3
Skin	UACC257	7.3
Skin	UACC62	7.6
Skin	WM115	8
Skin	WM1799	7.4
Skin	WM2664	7.4
Skin	WM793	7.7
Skin	WM88	7.5
Skin	WM983B	7.7
Small intestine	HUTU80	8.3
Soft tissue	A204	8.2
Soft tissue	G401	8.2
Soft tissue	G402	7.5
Soft tissue	GCT	8.3
Soft tissue	HS729	7.9
Soft tissue	HT1080	7.6
Soft tissue	KYM1	8.9
Soft tissue	MESSA	8.3
Soft tissue	RD	8
Soft tissue	RH30	7.8
Soft tissue	RH41	7
Soft tissue	RKN	7.4
Soft tissue	S117	6.9
Soft tissue	SJRH30	8.1
Soft tissue	SKLMS1	8.1
Soft tissue	SKUT1	8.4
Soft tissue	TE125T	7.9
Soft tissue	TE159T	7.6
Soft tissue	TE441T	9.6
Soft tissue	TE617T	8.3
Stomach	2313287	8.2
Stomach	AGS	7.9
Stomach	AZ521	8.5
Stomach	ECC10	8.9
Stomach	ECC12	8.3
Stomach	FU97	7.8
Stomach	GCIY	7.4
Stomach	GSS	8.4
Stomach	GSU	7.9
Stomach	HGC27	7.9
Stomach	HS746T	8.5
Stomach	HUG1N	7.6
Stomach	IM95	7.5
Stomach	KATOIII	8.1
Stomach	KE39	8.6
Stomach	LMSU	7.4
Stomach	MKN1	7.9
Stomach	MKN45	8.7
Stomach	MKN74	9.2
Stomach	MKN7	8.6
Stomach	NCCSTCK140	7.6
Stomach	NCIN87	8
Stomach	NUGC2	7
Stomach	NUGC3	8.3
Stomach	NUGC4	8.1
Stomach	OCUM1	7.8
Stomach	RERFGC1B	8.5
Stomach	SH10TC	7.5
Stomach	SNU16	7.7
Stomach	SNU1	8.1
Stomach	SNU216	8.8
Stomach	SNU520	7.5
Stomach	SNU5	7.4
Stomach	SNU601	7.4
Stomach	SNU620	7.7
Stomach	SNU668	9.5
Stomach	SNU719	7.5
Stomach	TGBC11TKB	8.5
Thyroid	8305C	7.5
Thyroid	8505C	8.6
Thyroid	BCPAP	8.2
Thyroid	BHT101	8.4
Thyroid	CAL62	8.2
Thyroid	CGTHW1	7.8
Thyroid	FTC133	7.2
Thyroid	FTC238	7.5
Thyroid	ML1	7.6
Thyroid	SW579	7.6
Thyroid	TT2609C02	7.9
Thyroid	TT	9.2
Upper aerodigestive tract	BHY	10
Upper aerodigestive tract	BICR16	7.6
Upper aerodigestive tract	BICR18	8
Upper aerodigestive tract	BICR22	7.1
Upper aerodigestive tract	BICR31	8.9
Upper aerodigestive tract	BICR56	8.7
Upper aerodigestive tract	BICR6	7.3
Upper aerodigestive tract	CAL27	8.2
Upper aerodigestive tract	CAL33	7.6
Upper aerodigestive tract	DETROIT562	8.8
Upper aerodigestive tract	FADU	7.3
Upper aerodigestive tract	HS840T	7.6
Upper aerodigestive tract	HSC2	8.3
Upper aerodigestive tract	HSC3	7.1
Upper aerodigestive tract	HSC4	9.4
Upper aerodigestive tract	PECAPJ15	7.4
Upper aerodigestive tract	PECAPJ34CLONEC12	6.9
Upper aerodigestive tract	PECAPJ41CLONED2	9.2
Upper aerodigestive tract	PECAPJ49	7.8
Upper aerodigestive tract	SCC15	7.3
Upper aerodigestive tract	SCC25	6.7
Upper aerodigestive tract	SCC4	7.2
Upper aerodigestive tract	SCC9	7.5
Upper aerodigestive tract	SNU1076	8
Upper aerodigestive tract	SNU1214	7.9
Upper aerodigestive tract	SNU46	8.3
Upper aerodigestive tract	SNU899	8.4
Upper aerodigestive tract	YD10B	8.2
Upper aerodigestive tract	YD38	8.5
Upper aerodigestive tract	YD8	7.9
Urinary tract	5637	7.8
Urinary tract	639V	8.3
Urinary tract	647V	8.4
Urinary tract	BC3C	7.3
Urinary tract	BFTC905	7.6
Urinary tract	CAL29	6.8
Urinary tract	HS172T	7.6
Urinary tract	HT1197	7.5
Urinary tract	HT1376	7.8
Urinary tract	J82	7.9
Urinary tract	JMSU1	8
Urinary tract	KMBC2	8.1
Urinary tract	KU1919	7.5
Urinary tract	RT11284	8
Urinary tract	RT112	7.4
Urinary tract	RT4	7.7
Urinary tract	SCABER	9
Urinary tract	SW1710	7.4
Urinary tract	SW780	7.8
Urinary tract	T24	8.1
Urinary tract	TCCSUP	6.5
Urinary tract	UMUC1	7.1
Urinary tract	UMUC3	8
Urinary tract	VMCUB1	8.3

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	14.1
Adrenal gland	24
Appendix	23.2
Bone marrow	16.7
Breast	18.6
Cerebral cortex	33.8
Cervix, uterine	26.4
Colon	12.9
Duodenum	9.8
Endometrium	33.5
Epididymis	10.9
Esophagus	15.7
Fallopian tube	23.7
Gallbladder	26.5
Heart muscle	9
Kidney	15.7
Liver	6.1
Lung	19.9
Lymph node	18.4
Ovary	32.5
Pancreas	3.5
Parathyroid gland	40.9
Placenta	26.4
Prostate	23.8
Rectum	14.3
Salivary gland	4.3
Seminal vesicle	18.6
Skeletal muscle	3
Skin	11.1
Small intestine	12.1
Smooth muscle	25.7
Spleen	22.9
Stomach	12.9
Testis	44.2
Thyroid gland	37.3
Tonsil	13.4
Urinary bladder	22.3

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
28289901	overexpression	Lung Carcinoma	In the present study, we found that there was a significant association between Rsf-1 overexpression and poor overall survival (p=0.028) in lung cancer.
28261335	overexpression	Nasopharyngeal Carcinoma	Results: Our present study demonstrated that both mRNA and protein expressions of RSF1 were increased and correlated with advanced NPC clinical stage.
25337201	Overexpression	Breast Carcinoma	Overexpression of Rsf-1 correlates with pathological type, p53 status and survival in primary breast cancer.
24798976	Overexpression	Hepatocellular Carcinoma	In the present study, we analyzed the expression pattern of Rsf-1 in human HCC tissues and found that Rsf-1 was overexpressed in 41.1 % of HCC specimens.
24584698	Overexpression	Prostate Carcinoma	Rsf-1 overexpression in human prostate cancer, implication as a prognostic marker. In conclusion, Rsf-1 is overexpressed in human prostate cancers and serves as a novel prognostic marker.
24566868	Overexpression; copy number gain	Ovarian Carcinoma	Overexpression or amplification of the RSF1 gene has been associated with poor prognosis in various human cancers, including ovarian cancer. In previous work, RSF1 was identified as an amplified gene that facilitated the development of paclitaxel-resistant ovarian cancer.
22977663	Overexpression	Gastric Adenocarcinoma	Immunohistochemical staining indicated that RSF-1 is highly expressed in 52.6% of gastric adenocarcinomas. Kaplan-Meier survival analysis showed that high RSF-1 expression exhibited a significant correlation with poor prognosis for gastric adenocarcinoma patients.
22685262	Overexpression	Bladder Urothelial Carcinoma	Rsf-1/HBXAP overexpression is independent of gene amplification and is associated with poor outcome in patients with urinary bladder urothelial carcinoma. Rsf-1 overexpression was demonstrated in 101 cases (34.2%), and was significantly associated with advanced primary tumour (p<0.001), nodal metastasis (p=0.004), higher histological grades (p=0.001) and frequent mitoses (p<0.001). Overexpression of Rsf-1 is associated with higher tumour stage and poorer clinical outcome.
22569540	Overexpression	Rectal Carcinoma	Present in 82 cases (47.7%), high-expression of Rsf-1 was associated with advanced pre-treatment tumour status (T3, T4, p=0.020), advanced post-treatment tumour status (T3, T4, p<0.001) and inferior tumour regression grade (p=0.028). High-expression of Rsf-1 is associated with poor therapeutic response and adverse outcome in rectal cancer patients treated with neoadjuvant CRT, which confers tumour aggressiveness and therapeutic resistance through chromatin remodelling and represents a potential prognostic biomarker in rectal cancer.
22528946	Overexpression	Colon Carcinoma	Rsf-1 overexpression correlates with poor prognosis and cell proliferation in colon cancer. Furthermore, Rsf-1 overexpression correlated with a poor prognosis in colon cancer patients (p = 0.0011).
22387541	Overexpression	Non-small Cell Lung Carcinoma	Rsf-1 is overexpressed in non-small cell lung cancers and regulates cyclinD1 expression and ERK activity. In the present study, we analyzed the expression pattern of Rsf-1 in NSCLC tissues and found that Rsf-1 was overexpressed at both the mRNA and protein levels.
22081787	Overexpression	Nasopharyngeal Carcinoma	Associations of Rsf-1 overexpression with poor therapeutic response and worse survival in patients with nasopharyngeal carcinoma. Present in 49 cases (45%), Rsf-1 overexpression was associated with N(2,3) status (p=0.016), American Joint Committee on Cancer stage 3, 4 (p=0.004), and incomplete therapeutic response (p=0.041).
22028712	Overexpression	Ovarian Serous Adenocarcinoma	DNA Damage Response is Prominent in Ovarian High-Grade Serous Carcinomas, Especially Those with Rsf-1 (HBXAP) Overexpression.
21995635	Overexpression	Gallbladder Carcinoma	Rsf-1/HBXAP overexpression is associated with disease-specific survival of patients with gallbladder carcinoma. The Rsf-1 overexpression, present in 61 cases (69.3%), was significantly associated with higher histological grades (p=0.002) and vascular invasion (p=0.037) and marginally with non-papillary histotypes (p=0.058). Our findings indicate that Rsf-1 overexpression is common and associated with adverse prognosticators in gallbladder carcinomas.
21514451	Overexpression	Oral Cavity Squamous Cell Carcinoma	Overexpression of a chromatin remodeling factor, RSF-1/HBXAP, correlates with aggressive oral squamous cell carcinoma. Univariate and multivariate analyses showed a significant association of RSF-1 overexpression and worse overall survival in OSCC patients. Taken together, our results suggest that RSF-1 up-regulation is associated with several clinicopathological features of disease aggressiveness in OSCC patients, and RSF-1 plays an important role in maintaining cellular growth and survival in OSCC.
21131837	Overexpression	Borderline Ovarian Clear Cell Adenofibroma with Intraepithelial Carcinoma	In conclusion, a higher expression level of Rsf-1 is associated with advanced clinical stage and lymph node metastasis in CCC.
20923775	Overexpression (copy number gain)	Ovarian Serous Adenocarcinoma	Rsf-1 (HBXAP) has been reported as an amplified gene in human cancer, including the highly aggressive ovarian serous carcinoma. The above findings suggest that increased Rsf-1 expression and thus excessive RSF activity, which occurs in tumors harboring Rsf-1 amplification, can induce chromosomal instability likely through DDR.
20228782	Overexpression	Serous Tubal Intraepithelial Carcinoma	Increased Rsf-1 and FASN immunoreactivity occurred in 63%, and 62% of STICs, respectively, compared with adjacent normal-appearing tubal epithelium. These results suggest that overexpression of Rsf-1, cyclin E and FASN occurs early in tumor progression.
19190325	Overexpression	Ovarian Carcinoma	We found that Rsf-1 was up-regulated in paclitaxel-resistant ovarian cancer cell lines, and Rsf-1 immunoreactivity in primary ovarian carcinoma tissues correlated with in vitro paclitaxel resistance.
18519663	Overexpression	Ovarian Carcinoma	Based on immunohistochemistry, we found that Rsf-1 and hSNF2H were co-upregulated in ovarian cancer tissues.
16938522	Overexpression (copy number gain)	Ovarian Serous Adenocarcinoma	Our previous study showed that Rsf-1 was an amplified gene that participated in the development of ovarian serous carcinoma. Thus, overexpression of Rsf-1 was significantly associated with high-grade ovarian serous carcinoma (P < .05), as compared with other types of ovarian tumors and breast carcinomas. Rsf-1 is frequently expressed and upregulated in ovarian carcinoma cells in effusions and is a novel prognostic marker for patients with post-chemotherapy recurrent disease.
18289639	Overexpression (copy number gain)	Ovarian Serous Adenocarcinoma	We recently identified Rsf-1, a chromatin-remodeling gene, as a potential oncogene that is frequently amplified and overexpressed in ovarian serous carcinoma, and demonstrated that its expression in carcinoma cells in effusions is associated with poor prognosis.
16844205	Overexpression	Ovarian Carcinoma	Rsf-1 is frequently expressed and upregulated in ovarian carcinoma cells in effusions and is a novel prognostic marker for patients with post-chemotherapy recurrent disease.

Summary
Symbol	RSF1
Name	remodeling and spacing factor 1
Aliases	XAP8; RSF-1; p325; HBXAP; hepatitis B virus x associated protein; HBV pX associated protein-8; HBV pX-associ ......
Location	11q14.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

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Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.54	5.31e-32	25	53.2	21.8	Neutral
BRCA	Breast invasive carcinoma	1075	0.702	2.89e-160	22.3	52.8	24.8	Neutral
CESC	Cervical and endocervical cancers	292	0.492	3.48e-19	30.1	58.9	11	Neutral
COAD	Colon adenocarcinoma	449	0.229	9.63e-07	14	73.9	12	Neutral
ESCA	Esophageal carcinoma	183	0.611	4.34e-20	29.5	44.3	26.2	Neutral
GBM	Glioblastoma multiforme	147	0.3	0.000221	16.3	81	2.7	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.563	2.66e-44	30.4	46.9	22.8	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.165	0.000152	3.8	90.1	6.1	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.081	0.169	6.6	89.9	3.5	Neutral
LAML	Acute Myeloid Leukemia	166	0.404	6.61e-08	0	95.8	4.2	Neutral
LGG	Brain Lower Grade Glioma	513	0.248	1.31e-08	3.7	85.6	10.7	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.325	2.26e-10	19	73.1	8	Neutral
LUAD	Lung adenocarcinoma	512	0.492	1.35e-32	12.5	55.3	32.2	Neutral
LUSC	Lung squamous cell carcinoma	498	0.534	4.33e-38	25.5	48.6	25.9	Neutral
OV	Ovarian serous cystadenocarcinoma	300	0.763	1.94e-58	13.3	39.3	47.3	Gain
PAAD	Pancreatic adenocarcinoma	177	0.375	2.8e-07	7.9	83.6	8.5	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.517	1.8e-12	25.3	71.6	3.1	Neutral
PRAD	Prostate adenocarcinoma	491	0.191	2.14e-05	0.6	90.6	8.8	Neutral
READ	Rectum adenocarcinoma	164	0.303	7.9e-05	18.9	63.4	17.7	Neutral
SARC	Sarcoma	255	0.509	3.27e-18	27.8	55.3	16.9	Neutral
SKCM	Skin Cutaneous Melanoma	367	0.581	1.58e-34	31.9	51.2	16.9	Neutral
STAD	Stomach adenocarcinoma	413	0.514	3.22e-29	11.9	64.4	23.7	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.361	5.85e-06	76	21.3	2.7	Loss
THCA	Thyroid carcinoma	497	0.157	0.000425	1.8	97.2	1	Neutral
THYM	Thymoma	119	0.313	0.000528	5.9	93.3	0.8	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.466	2.49e-30	10.1	79.3	10.6	Neutral

Summary
Symbol	RSF1
Name	remodeling and spacing factor 1
Aliases	XAP8; RSF-1; p325; HBXAP; hepatitis B virus x associated protein; HBV pX associated protein-8; HBV pX-associ ......
Location	11q14.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

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Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.255	1.06e-07	17	408	0.049	3.7e-06	NS/NA
BRCA	Breast invasive carcinoma	-0.386	0	83	785	0.001	0.816	NS/NA
CESC	Cervical and endocervical cancers	-0.369	2.74e-11	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.271	1.08e-06	19	297	0.002	0.0665	NS/NA
ESCA	Esophageal carcinoma	-0.431	5.04e-10	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.247	0.0476	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.53	0	20	522	0.003	0.00646	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.286	8.39e-08	24	319	0.016	0.381	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.367	8.26e-11	23	275	0.005	9.71e-06	NS/NA
LAML	Acute Myeloid Leukemia	-0.205	0.00734	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.199	3.95e-06	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.26	9e-08	41	373	0.004	0.000489	NS/NA
LUAD	Lung adenocarcinoma	-0.165	0.000313	21	456	0.001	0.06	NS/NA
LUSC	Lung squamous cell carcinoma	-0.24	2.51e-06	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.867	0.00451	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.277	0.000159	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.354	7.78e-07	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.384	0	35	498	0.013	0.0195	NS/NA
READ	Rectum adenocarcinoma	-0.355	0.000294	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.314	2.31e-07	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.429	0	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.417	0	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.211	0.00817	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.168	6.39e-05	50	509	0.018	0.0277	NS/NA
THYM	Thymoma	-0.145	0.111	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.148	0.0014	34	431	0	0.41	NS/NA

Summary
Symbol	RSF1
Name	remodeling and spacing factor 1
Aliases	XAP8; RSF-1; p325; HBXAP; hepatitis B virus x associated protein; HBV pX associated protein-8; HBV pX-associ ......
Location	11q14.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	2	Medium
Appendix	2	Medium
Bone marrow	2	Medium
Breast	2	Medium
Bronchus	2	Medium
Caudate	1	Low
Cerebellum	1	Low
Cerebral cortex	3	High
Cervix, uterine	2	Medium
Colon	2	Medium
Duodenum	2	Medium
Endometrium	2	Medium
Epididymis	2	Medium
Esophagus	3	High
Fallopian tube	2	Medium
Gallbladder	2	Medium
Heart muscle	1	Low
Hippocampus	2	Medium
Kidney	2	Medium
Liver	0	Not detected
Lung	3	High
Lymph node	1	Low
Nasopharynx	3	High
Oral mucosa	2	Medium
Ovary	2	Medium
Pancreas	2	Medium
Parathyroid gland	2	Medium
Placenta	3	High
Prostate	1	Low
Rectum	2	Medium
Salivary gland	2	Medium
Seminal vesicle	2	Medium
Skeletal muscle	1	Low
Skin	2	Medium
Small intestine	1	Low
Smooth muscle	2	Medium
Soft tissue	2	Medium
Spleen	3	High
Stomach	1	Low
Testis	2	Medium
Thyroid gland	3	High
Tonsil	2	Medium
Urinary bladder	2	Medium
Vagina	3	High

Summary
Symbol	RSF1
Name	remodeling and spacing factor 1
Aliases	XAP8; RSF-1; p325; HBXAP; hepatitis B virus x associated protein; HBV pX associated protein-8; HBV pX-associ ......
Location	11q14.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.534	NS	24476821
BRCA	Breast invasive carcinoma	521	0.0791	NS	23000897
COAD	Colon adenocarcinoma	149	0.958	NS	22810696
GBM	Glioblastoma multiforme	157	0.00366	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	0.629	NS	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.0454	Significant	26536169
LGG	Brain Lower Grade Glioma	513	1.1e-20	Significant	26824661
LUAD	Lung adenocarcinoma	230	0.277	NS	25079552
LUSC	Lung squamous cell carcinoma	178	0.0345	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.894	NS	21720365
PRAD	Prostate adenocarcinoma	333	0.000919	Significant	26544944
READ	Rectum adenocarcinoma	67	0.453	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.107	NS	26091043
STAD	Stomach adenocarcinoma	277	0.255	NS	25079317
THCA	Thyroid carcinoma	391	0.00121	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.000698	Significant	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	1.136	0.565	NS
BRCA	Breast invasive carcinoma	1079	0.899	0.658	NS
CESC	Cervical and endocervical cancers	291	1.611	0.175	NS
COAD	Colon adenocarcinoma	439	1.35	0.338	NS
ESCA	Esophageal carcinoma	184	0.759	0.411	NS
GBM	Glioblastoma multiforme	158	0.728	0.211	NS
HNSC	Head and Neck squamous cell carcinoma	518	0.774	0.187	NS
KIRC	Kidney renal clear cell carcinoma	531	0.333	1.7e-06	Longer
KIRP	Kidney renal papillary cell carcinoma	287	1.943	0.139	NS
LAML	Acute Myeloid Leukemia	149	0.959	0.885	NS
LGG	Brain Lower Grade Glioma	511	0.601	0.0261	Longer
LIHC	Liver hepatocellular carcinoma	365	1.031	0.903	NS
LUAD	Lung adenocarcinoma	502	1.225	0.349	NS
LUSC	Lung squamous cell carcinoma	494	0.974	0.892	NS
OV	Ovarian serous cystadenocarcinoma	303	1.03	0.889	NS
PAAD	Pancreatic adenocarcinoma	177	2.377	0.0038	Shorter
PCPG	Pheochromocytoma and Paraganglioma	179	2043348403.237	0.0289	Shorter
PRAD	Prostate adenocarcinoma	497	0.998	0.999	NS
READ	Rectum adenocarcinoma	159	0.601	0.479	NS
SARC	Sarcoma	259	0.969	0.912	NS
SKCM	Skin Cutaneous Melanoma	459	0.806	0.267	NS
STAD	Stomach adenocarcinoma	388	1.284	0.279	NS
TGCT	Testicular Germ Cell Tumors	134	0.891	0.935	NS
THCA	Thyroid carcinoma	500	0.609	0.513	NS
THYM	Thymoma	119	0.747	0.772	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	1.924	0.0296	Shorter

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	-0.014	0.773	NS
BRCA	Breast invasive carcinoma	1071	-0.009	0.775	NS
CESC	Cervical and endocervical cancers	167	-0.034	0.659	NS
COAD	Colon adenocarcinoma	445	0.066	0.168	NS
ESCA	Esophageal carcinoma	162	0.107	0.174	NS
HNSC	Head and Neck squamous cell carcinoma	448	-0.034	0.478	NS
KIRC	Kidney renal clear cell carcinoma	531	-0.173	6.01e-05	Lower
KIRP	Kidney renal papillary cell carcinoma	260	0.049	0.432	NS
LIHC	Liver hepatocellular carcinoma	347	-0.018	0.74	NS
LUAD	Lung adenocarcinoma	507	0.062	0.163	NS
LUSC	Lung squamous cell carcinoma	497	0.056	0.215	NS
OV	Ovarian serous cystadenocarcinoma	302	-0.014	0.806	NS
PAAD	Pancreatic adenocarcinoma	176	0.091	0.228	NS
READ	Rectum adenocarcinoma	156	0.094	0.243	NS
SKCM	Skin Cutaneous Melanoma	410	-0.061	0.218	NS
STAD	Stomach adenocarcinoma	392	0.067	0.183	NS
TGCT	Testicular Germ Cell Tumors	81	0.067	0.555	NS
THCA	Thyroid carcinoma	499	-0.059	0.189	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.121	0.00681	Higher

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	-0.011	0.856	NS
HNSC	Head and Neck squamous cell carcinoma	498	0.036	0.429	NS
KIRC	Kidney renal clear cell carcinoma	525	-0.182	2.79e-05	Lower
LGG	Brain Lower Grade Glioma	514	-0.041	0.35	NS
LIHC	Liver hepatocellular carcinoma	366	-0.044	0.404	NS
OV	Ovarian serous cystadenocarcinoma	296	0.004	0.95	NS
PAAD	Pancreatic adenocarcinoma	176	0.144	0.0565	NS
STAD	Stomach adenocarcinoma	406	0.062	0.211	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.264	5.91e-10	Higher

Summary
Symbol	RSF1
Name	remodeling and spacing factor 1
Aliases	XAP8; RSF-1; p325; HBXAP; hepatitis B virus x associated protein; HBV pX associated protein-8; HBV pX-associ ......
Location	11q14.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	RSF1
Name	remodeling and spacing factor 1
Aliases	XAP8; RSF-1; p325; HBXAP; hepatitis B virus x associated protein; HBV pX associated protein-8; HBV pX-associ ......
Location	11q14.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for RSF1.

Summary
Symbol	RSF1
Name	remodeling and spacing factor 1
Aliases	XAP8; RSF-1; p325; HBXAP; hepatitis B virus x associated protein; HBV pX associated protein-8; HBV pX-associ ......
Location	11q14.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
24566868	Ovarian Carcinoma	partner	NF-κB; CREBBP; hSNF2H	Binding	A coimmunoprecipitation assay revealed that RSF1 interacts with NF-κB and CREB-binding protein, a ubiquitous coactivator for NF-κB. Furthermore, hSNF2H, a well-known binding partner of RSF1, was partially involved in the interaction between RSF1 and NF-κB.
23378270	Ovarian Carcinoma	partner	Cyclin E1	Binding	The above findings suggest that Rsf-1 interacts and collaborates with cyclin E1 in neoplastic transformation and TP53 mutations are a prerequisite for tumour-promoting functions of the RSF/cyclin E1 complex.
22528946	Colon Carcinoma	downstream	Cyclin E1; Phospho-Rb	Positive regulation	Further analysis showed that Rsf-1 knockdown decreased cyclin E expression and phospho-Rb level. In conclusion, Rsf-1 is overexpressed in colon cancers and contributes to malignant cell growth by cyclin E and phospho-Rb modulation, which makes Rsf-1 a candidate therapeutic target in colon cancer.
22387541	Non-small Cell Lung Carcinoma	downstream	Cyclin D1; Phospho-ERK	Positive regulation	Further analysis showed that Rsf-1 knockdown decreased cyclin D1 expression and phospho-ERK levels. In conclusion, Rsf-1 is overexpressed in NSCLC and contributes to malignant cell growth by cyclin D1 and ERK modulation, which makes Rsf-1 a candidate therapeutic target in lung cancer.
20923775	Ovarian Serous Adenocarcinoma	partner	SNF2H	Binding	Rsf-1 protein interacts with SNF2H to form an ISWI chromatin remodeling complex, RSF.
19190325	Ovarian Carcinoma	partner	hSNF2H	Binding	Rsf-1 has been known to interact with hSNF2H to form an ISWI chromatin remodeling complex.
18519663	Ovarian Carcinoma	partner	hSNF2H	Binding; Co-upregulated	Rsf-1 interacts with human sucrose nonfermenting protein 2 homologue (hSNF2H) to form a chromatin remodeling complex that participates in several biological processes. Based on immunohistochemistry, we found that Rsf-1 and hSNF2H were co-upregulated in ovarian cancer tissues.