CR2Cancer

Summary
Symbol	SCML2
Name	sex comb on midleg like 2 (Drosophila)
Aliases	sex comb on midleg (Drosophila)-like 2; Sex comb on midleg-like protein 2
Location	Xp22.13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

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Domain

PF02820 mbt repeat
PF17208 RNA binding Region
PF00536 SAM domain (Sterile alpha motif)
PF12140 SLED domain

Function

Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development (By similarity).

Classification

Class	Modification	Substrate	Product	PubMed
Polycomb group (PcG) protein	#	#	#	24727478

> Gene Ontology [ TOP ]
Biological Process	-
Molecular Function	-
Cellular Component	GO:0031519 PcG protein complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	-

Summary
Symbol	SCML2
Name	sex comb on midleg like 2 (Drosophila)
Aliases	sex comb on midleg (Drosophila)-like 2; Sex comb on midleg-like protein 2
Location	Xp22.13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM3560211	c.891G>A	p.R297R	Substitution - coding silent	Skin
COSM3560215	c.475T>A	p.L159I	Substitution - Missense	Skin
COSM1264946	c.905A>C	p.K302T	Substitution - Missense	Oesophagus
COSM3035796	c.782G>T	p.S261I	Substitution - Missense	Large_intestine
COSM1720336	c.332A>T	p.D111V	Substitution - Missense	Skin
COSM3560203	c.1998C>T	p.F666F	Substitution - coding silent	Skin
COSM1264947	c.1954G>A	p.A652T	Substitution - Missense	Oesophagus
COSM1467076	c.1928C>T	p.T643I	Substitution - Missense	Large_intestine
COSM164201	c.93T>C	p.D31D	Substitution - coding silent	Breast
COSM3759441	c.342C>T	p.D114D	Substitution - coding silent	Central_nervous_system
COSM247199	c.581T>C	p.I194T	Substitution - Missense	Prostate
COSM170536	c.1723C>T	p.R575*	Substitution - Nonsense	Large_intestine
COSM3560216	c.462G>A	p.M154I	Substitution - Missense	Skin
COSM4399235	c.1117C>T	p.P373S	Substitution - Missense	Skin
COSM5988781	c.1117C>A	p.P373T	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5885002	c.1253G>A	p.R418H	Substitution - Missense	Large_intestine
COSM3390546	c.943A>G	p.K315E	Substitution - Missense	Pancreas
COSM1737806	c.1717T>A	p.F573I	Substitution - Missense	Central_nervous_system
COSM4515409	c.1093_1094GG>AA	p.G365K	Substitution - Missense	Skin
COSM3747400	c.1068A>G	p.T356T	Substitution - coding silent	Liver
COSM3939902	c.845G>C	p.R282T	Substitution - Missense	Oesophagus
COSM4723975	c.1523T>C	p.V508A	Substitution - Missense	Large_intestine
COSM1319466	c.139G>T	p.A47S	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4108455	c.1842A>G	p.V614V	Substitution - coding silent	Stomach
COSM4723977	c.1288_1289insG	p.E430fs*21	Insertion - Frameshift	Large_intestine
COSM5791660	c.148G>C	p.E50Q	Substitution - Missense	Breast
COSM164202	c.330C>T	p.V110V	Substitution - coding silent	Skin
COSM3406210	c.90G>A	p.R30R	Substitution - coding silent	Central_nervous_system
COSM5927976	c.201G>A	p.M67I	Substitution - Missense	Skin
COSM3560210	c.931C>T	p.P311S	Substitution - Missense	Skin
COSM1118755	c.1850C>A	p.P617H	Substitution - Missense	Endometrium
COSM1224804	c.166C>G	p.Q56E	Substitution - Missense	Large_intestine
COSM164201	c.93T>C	p.D31D	Substitution - coding silent	Breast
COSM5807586	c.281G>C	p.R94P	Substitution - Missense	Liver
COSM488225	c.6A>G	p.G2G	Substitution - coding silent	Kidney
COSM270870	c.1412G>T	p.R471M	Substitution - Missense	Large_intestine
COSM3560217	c.94G>A	p.D32N	Substitution - Missense	Skin
COSM164202	c.330C>T	p.V110V	Substitution - coding silent	Breast
COSM1319467	c.1764C>T	p.D588D	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM3035776	c.1938G>A	p.Q646Q	Substitution - coding silent	Skin
COSM1714702	c.1714G>A	p.D572N	Substitution - Missense	Skin
COSM4949762	c.23-2A>T	p.?	Unknown	Liver
COSM3560213	c.733C>T	p.P245S	Substitution - Missense	Skin
COSM315007	c.2031G>T	p.M677I	Substitution - Missense	Lung
COSM1467077	c.1493G>T	p.R498L	Substitution - Missense	Large_intestine
COSM1636457	c.971G>T	p.C324F	Substitution - Missense	Liver
COSM5692276	c.1277C>T	p.S426F	Substitution - Missense	Soft_tissue
COSM4400687	c.494C>T	p.P165L	Substitution - Missense	Skin
COSM1625756	c.94delG	p.D32fs*8	Deletion - Frameshift	Liver
COSM1490761	c.256A>G	p.I86V	Substitution - Missense	Breast
COSM3035793	c.918A>T	p.P306P	Substitution - coding silent	Large_intestine
COSM1756492	c.1155G>A	p.P385P	Substitution - coding silent	Urinary_tract
COSM273750	c.1951_1952insC	p.L651fs*9	Insertion - Frameshift	Large_intestine
COSM1467079	c.308G>T	p.R103I	Substitution - Missense	Large_intestine
COSM3844242	c.1031A>G	p.D344G	Substitution - Missense	Breast
COSM1118770	c.140C>A	p.A47D	Substitution - Missense	Endometrium
COSM3747399	c.1890C>G	p.T630T	Substitution - coding silent	Liver
COSM3844243	c.685T>G	p.W229G	Substitution - Missense	Breast
COSM2149741	c.1883C>A	p.P628H	Substitution - Missense	Central_nervous_system
COSM315007	c.2031G>T	p.M677I	Substitution - Missense	Soft_tissue
COSM5723289	c.607C>T	p.H203Y	Substitution - Missense	Skin
COSM212431	c.224G>A	p.R75H	Substitution - Missense	Breast
COSM284811	c.1094G>T	p.G365V	Substitution - Missense	Large_intestine
COSM356396	c.364G>A	p.E122K	Substitution - Missense	Lung
COSM3560206	c.1669C>T	p.P557S	Substitution - Missense	Skin
COSM235316	c.675C>T	p.F225F	Substitution - coding silent	Skin
COSM1720336	c.332A>T	p.D111V	Substitution - Missense	Skin
COSM4750651	c.108G>T	p.E36D	Substitution - Missense	Stomach
COSM5723289	c.607C>T	p.H203Y	Substitution - Missense	Skin
COSM1163564	c.319_320insT	p.W107fs*16	Insertion - Frameshift	Pancreas
COSM4472733	c.1801C>T	p.Q601*	Substitution - Nonsense	Skin
COSM3560214	c.555C>T	p.N185N	Substitution - coding silent	Skin
COSM3560208	c.1128C>T	p.I376I	Substitution - coding silent	Skin
COSM1467078	c.1256G>A	p.G419E	Substitution - Missense	Large_intestine
COSM3844240	c.1670C>T	p.P557L	Substitution - Missense	Breast
COSM1331942	c.1623A>G	p.S541S	Substitution - coding silent	Ovary
COSM5366858	c.310A>C	p.N104H	Substitution - Missense	Large_intestine
COSM357787	c.1430C>T	p.S477F	Substitution - Missense	Lung
COSM1118754	c.1878G>T	p.K626N	Substitution - Missense	Endometrium
COSM4564375	c.1153_1154CC>TT	p.P385L	Substitution - Missense	Skin
COSM1264945	c.1036G>A	p.A346T	Substitution - Missense	Stomach
COSM3844241	c.1163T>G	p.V388G	Substitution - Missense	Breast
COSM4108457	c.10A>C	p.T4P	Substitution - Missense	Stomach
COSM5662356	c.1672G>C	p.A558P	Substitution - Missense	Soft_tissue
COSM121800	c.339A>G	p.P113P	Substitution - coding silent	Upper_aerodigestive_tract
COSM1118760	c.1575A>G	p.E525E	Substitution - coding silent	Endometrium
COSM5814437	c.1578A>G	p.P526P	Substitution - coding silent	Liver
COSM4883178	c.1044G>T	p.G348G	Substitution - coding silent	Upper_aerodigestive_tract
COSM3035796	c.782G>T	p.S261I	Substitution - Missense	Large_intestine
COSM1118767	c.427A>G	p.M143V	Substitution - Missense	Endometrium
COSM4108456	c.1012C>T	p.R338C	Substitution - Missense	Stomach
COSM5711570	c.552_553insA	p.N185fs*14	Insertion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM5412401	c.1665G>A	p.L555L	Substitution - coding silent	Skin
COSM4169834	c.277T>A	p.L93I	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4796874	c.1305G>A	p.Q435Q	Substitution - coding silent	Liver
COSM1118763	c.1159C>A	p.P387T	Substitution - Missense	Endometrium
COSM3719354	c.1079A>G	p.Y360C	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3913729	c.1655G>A	p.G552E	Substitution - Missense	Skin
COSM5723289	c.607C>T	p.H203Y	Substitution - Missense	Skin
COSM1118756	c.1776G>A	p.K592K	Substitution - coding silent	Endometrium
COSM211501	c.1354T>A	p.F452I	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4108456	c.1012C>T	p.R338C	Substitution - Missense	Stomach
COSM1636457	c.971G>T	p.C324F	Substitution - Missense	Liver
COSM301062	c.444A>G	p.T148T	Substitution - coding silent	Large_intestine
COSM3560209	c.998C>T	p.S333L	Substitution - Missense	Skin
COSM5437523	c.277T>G	p.L93V	Substitution - Missense	Oesophagus
COSM756632	c.640G>C	p.D214H	Substitution - Missense	Lung
COSM4773897	c.487-1G>A	p.?	Unknown	Stomach
COSM756635	c.1647A>T	p.L549L	Substitution - coding silent	Lung
COSM1118759	c.1614G>T	p.E538D	Substitution - Missense	Endometrium
COSM4569371	c.170T>C	p.I57T	Substitution - Missense	Skin
COSM756634	c.883C>G	p.P295A	Substitution - Missense	Lung
COSM1118761	c.1533_1534delTC	p.P512fs*1	Deletion - Frameshift	Endometrium
COSM5723289	c.607C>T	p.H203Y	Substitution - Missense	Skin
COSM1118758	c.1705G>T	p.V569F	Substitution - Missense	Endometrium
COSM1315404	c.764C>T	p.S255F	Substitution - Missense	Urinary_tract
COSM756636	c.1995G>T	p.L665L	Substitution - coding silent	Lung
COSM3035786	c.1385delT	p.L462fs*1	Deletion - Frameshift	Large_intestine
COSM5777739	c.162+10G>A	p.?	Unknown	Breast
COSM4796874	c.1305G>A	p.Q435Q	Substitution - coding silent	Liver
COSM1726423	c.199A>G	p.M67V	Substitution - Missense	Liver
COSM1118768	c.426G>A	p.P142P	Substitution - coding silent	Endometrium
COSM3759441	c.342C>T	p.D114D	Substitution - coding silent	Large_intestine
COSM1118762	c.1457-2A>T	p.?	Unknown	Endometrium
COSM4333259	c.947A>G	p.K316R	Substitution - Missense	Biliary_tract
COSM4643400	c.623G>A	p.G208D	Substitution - Missense	Large_intestine
COSM1714702	c.1714G>A	p.D572N	Substitution - Missense	Skin
COSM3670278	c.774C>T	p.S258S	Substitution - coding silent	Central_nervous_system
COSM4826526	c.921G>C	p.R307S	Substitution - Missense	Cervix
COSM1714701	c.2099G>A	p.S700N	Substitution - Missense	Skin
COSM3035796	c.782G>T	p.S261I	Substitution - Missense	Large_intestine
COSM4723976	c.1446A>C	p.K482N	Substitution - Missense	Large_intestine
COSM1118766	c.441G>T	p.K147N	Substitution - Missense	Endometrium
COSM3560207	c.1542C>T	p.L514L	Substitution - coding silent	Skin
COSM1118765	c.483G>T	p.K161N	Substitution - Missense	Endometrium
COSM4418844	c.342C>A	p.D114E	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1118769	c.251C>T	p.T84M	Substitution - Missense	Endometrium
COSM4935916	c.835C>G	p.Q279E	Substitution - Missense	Liver
COSM3560212	c.840C>T	p.V280V	Substitution - coding silent	Skin
COSM4977126	c.528G>A	p.M176I	Substitution - Missense	Oesophagus
COSM1557353	c.1360C>T	p.H454Y	Substitution - Missense	Central_nervous_system
COSM1756492	c.1155G>A	p.P385P	Substitution - coding silent	Urinary_tract
COSM5519850	c.1154C>T	p.P385L	Substitution - Missense	Biliary_tract
COSM1682427	c.1906G>A	p.V636M	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1118757	c.1736G>A	p.G579D	Substitution - Missense	Endometrium
COSM5921950	c.764C>A	p.S255Y	Substitution - Missense	Skin
COSM488224	c.91G>C	p.D31H	Substitution - Missense	Kidney
COSM4951716	c.430T>G	p.F144V	Substitution - Missense	Liver
COSM164201	c.93T>C	p.D31D	Substitution - coding silent	Breast
COSM3560202	c.2090G>A	p.G697E	Substitution - Missense	Skin
COSM5799798	c.1327T>G	p.S443A	Substitution - Missense	Breast
COSM3035784	c.1406C>A	p.S469Y	Substitution - Missense	Large_intestine
COSM5588884	c.1724G>A	p.R575Q	Substitution - Missense	Skin
COSM5430246	c.1665G>C	p.L555F	Substitution - Missense	Oesophagus
COSM1118764	c.980C>A	p.S327Y	Substitution - Missense	Endometrium
COSM4005062	c.1789G>T	p.E597*	Substitution - Nonsense	Urinary_tract
COSM1714702	c.1714G>A	p.D572N	Substitution - Missense	Skin
COSM323214	c.1892G>T	p.W631L	Substitution - Missense	Lung
COSM3560204	c.1962C>T	p.L654L	Substitution - coding silent	Skin
COSM4888165	c.1438C>A	p.H480N	Substitution - Missense	Upper_aerodigestive_tract
COSM1472234	c.1313C>T	p.P438L	Substitution - Missense	Prostate
COSM3844243	c.685T>G	p.W229G	Substitution - Missense	Breast
COSM4951716	c.430T>G	p.F144V	Substitution - Missense	Liver
COSM5368051	c.1823-8_1823-7insC	p.?	Unknown	Large_intestine
COSM1664052	c.1501C>T	p.Q501*	Substitution - Nonsense	Kidney
COSM3560205	c.1880A>C	p.D627A	Substitution - Missense	Skin
COSM4949762	c.23-2A>T	p.?	Unknown	Liver
COSM756637	c.2063G>T	p.C688F	Substitution - Missense	Lung
COSM756633	c.779C>A	p.A260E	Substitution - Missense	Lung

> Text Mining based Variations [ TOP ]
There is no record for SCML2.

Summary
Symbol	SCML2
Name	sex comb on midleg like 2 (Drosophila)
Aliases	sex comb on midleg (Drosophila)-like 2; Sex comb on midleg-like protein 2
Location	Xp22.13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

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Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
Q9UQR0	261	S	Phosphoserine	-	No	None detected
Q9UQR0	267	S	Phosphoserine	-	No	None detected
Q9UQR0	299	S	Phosphoserine	-	No	None detected
Q9UQR0	300	S	Phosphoserine	-	No	None detected
Q9UQR0	305	T	Phosphothreonine	-	No	None detected
Q9UQR0	499	S	Phosphoserine	-	No	None detected
Q9UQR0	503	T	Phosphothreonine	-	Yes	p.T503P (cancer: COAD)
Q9UQR0	511	S	Phosphoserine	-	No	None detected
Q9UQR0	522	S	Phosphoserine	-	No	None detected
Q9UQR0	570	S	Phosphoserine	-	No	None detected
Q9UQR0	583	S	Phosphoserine	-	No	None detected
Q9UQR0	590	S	Phosphoserine	-	No	None detected
Q9UQR0	594	S	Phosphoserine	-	No	None detected

Summary
Symbol	SCML2
Name	sex comb on midleg like 2 (Drosophila)
Aliases	sex comb on midleg (Drosophila)-like 2; Sex comb on midleg-like protein 2
Location	Xp22.13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

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Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	0.654	-0.489	-0.932	0.0995	NS
BRCA	Breast invasive carcinoma	112	1100	1.297	1.228	-0.079	0.63	NS
CESC	Cervical and endocervical cancers	3	306	1.97	1.593	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	0.883	1.694	0.6	0.0201	Over
ESCA	Esophageal carcinoma	11	185	0.55	1.269	0.273	0.771	NS
GBM	Glioblastoma multiforme	5	166	0.737	1.532	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	0.486	0.132	-0.376	0.205	NS
KIRC	Kidney renal clear cell carcinoma	72	534	0.431	-0.37	-0.793	2.32e-09	Under
KIRP	Kidney renal papillary cell carcinoma	32	291	0.255	-0.05	-0.334	0.191	NS
LAML	Acute Myeloid Leukemia	0	173	NA	5.005	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	1.638	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	0.09	1.187	1.104	3.8e-09	Over
LUAD	Lung adenocarcinoma	59	517	-0.394	-0.132	0.538	0.00676	NS
LUSC	Lung squamous cell carcinoma	51	501	-0.321	1.594	1.604	1.95e-09	Over
OV	Ovarian serous cystadenocarcinoma	0	307	NA	2.196	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	-0.022	-0.672	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	3.527	1.914	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	0.755	0.794	0.115	0.265	NS
READ	Rectum adenocarcinoma	10	167	1.222	1.687	0.302	0.593	NS
SARC	Sarcoma	2	263	0.978	2.877	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	-1.107	0.928	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	0.681	0.979	0.189	0.642	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	4.056	NA	NA	NA
THCA	Thyroid carcinoma	59	509	2.086	0.422	-1.534	6.26e-28	Under
THYM	Thymoma	2	120	2.372	2.386	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	1.852	0.628	-1.274	7.91e-06	Under

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	1.5
Adrenal gland	5
Appendix	1.7
Bone marrow	3.7
Breast	2.1
Cerebral cortex	1.7
Cervix, uterine	1.8
Colon	1
Duodenum	1.2
Endometrium	4.1
Epididymis	1.2
Esophagus	1
Fallopian tube	1.7
Gallbladder	1
Heart muscle	0.4
Kidney	0.7
Liver	0.5
Lung	0.7
Lymph node	1.3
Ovary	6.2
Pancreas	0.1
Parathyroid gland	2.7
Placenta	2.4
Prostate	1.7
Rectum	1.4
Salivary gland	2.6
Seminal vesicle	1.4
Skeletal muscle	0.3
Skin	2.3
Small intestine	0.9
Smooth muscle	3.4
Spleen	1.6
Stomach	0.3
Testis	19.1
Thyroid gland	3.7
Tonsil	1.1
Urinary bladder	1.1

> Text Mining based Expression

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PMID	Expression	Cancer	Evidence
18410541	Overexpression	Acute Myeloid Leukemia	To analyse the role of deregulated PcG genes in acute myeloid leukaemia (AML), we determined by RQ-PCR the expression of the PcG genes BMI-1, MEL18, SCML2, YY1 and EZH2, and the downstream PcG targets HOXA4, HOXA9 and MEIS1 in diagnostic bone marrow samples from 126 AML patients.; There was a general overexpression of the genes in AML patients compared to 20 healthy donors, except of HOXA4 and MEL18, which both displayed a wide range of expression levels within the AML subgroups. inv(16) positive patients showed significantly different expression of SCML2, BMI-1, YY1, HOXA9 and MEIS1 (P < or = 0.01).

Summary
Symbol	SCML2
Name	sex comb on midleg like 2 (Drosophila)
Aliases	sex comb on midleg (Drosophila)-like 2; Sex comb on midleg-like protein 2
Location	Xp22.13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.053	0.292	19.3	62.1	18.6	Neutral
BRCA	Breast invasive carcinoma	1075	0.105	0.000576	17.9	65.2	16.9	Neutral
CESC	Cervical and endocervical cancers	292	0.038	0.513	21.6	61	17.5	Neutral
COAD	Colon adenocarcinoma	449	-0.012	0.806	15.4	67.5	17.1	Neutral
ESCA	Esophageal carcinoma	183	0.024	0.748	35	50.3	14.8	Loss
GBM	Glioblastoma multiforme	147	0.161	0.0516	25.2	69.4	5.4	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.055	0.215	29.2	61.7	9.1	Neutral
KIRC	Kidney renal clear cell carcinoma	525	-0.11	0.0114	9.9	84.6	5.5	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	-0.105	0.0748	11.5	57.3	31.2	Neutral
LAML	Acute Myeloid Leukemia	166	-0.049	0.527	3	95.8	1.2	Neutral
LGG	Brain Lower Grade Glioma	513	0.067	0.131	20.5	74.5	5.1	Neutral
LIHC	Liver hepatocellular carcinoma	364	-0.068	0.195	29.7	60.2	10.2	Neutral
LUAD	Lung adenocarcinoma	512	-0.014	0.749	26	63.7	10.4	Neutral
LUSC	Lung squamous cell carcinoma	498	0.093	0.039	29.1	55.6	15.3	Neutral
OV	Ovarian serous cystadenocarcinoma	300	0.158	0.00596	56.3	26.7	17	Loss
PAAD	Pancreatic adenocarcinoma	177	0.344	2.75e-06	14.1	80.8	5.1	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.122	0.122	27.8	67.9	4.3	Neutral
PRAD	Prostate adenocarcinoma	491	0.185	3.81e-05	5.3	89.6	5.1	Neutral
READ	Rectum adenocarcinoma	164	0.157	0.0441	16.5	64	19.5	Neutral
SARC	Sarcoma	255	0.154	0.014	24.3	42.4	33.3	Neutral
SKCM	Skin Cutaneous Melanoma	367	0.068	0.196	22.9	62.1	15	Neutral
STAD	Stomach adenocarcinoma	413	0.104	0.0348	15.7	70	14.3	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.136	0.0963	18	62.7	19.3	Neutral
THCA	Thyroid carcinoma	497	0.086	0.0568	0.6	97.6	1.8	Neutral
THYM	Thymoma	119	0.112	0.224	6.7	91.6	1.7	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	-0.03	0.494	15.1	70.6	14.3	Neutral

Summary
Symbol	SCML2
Name	sex comb on midleg like 2 (Drosophila)
Aliases	sex comb on midleg (Drosophila)-like 2; Sex comb on midleg-like protein 2
Location	Xp22.13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.2	3.34e-05	17	408	-0.013	0.25	NS/NA
BRCA	Breast invasive carcinoma	-0.274	2.45e-16	83	785	0.001	0.00184	NS/NA
CESC	Cervical and endocervical cancers	-0.302	7.5e-08	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.273	8.95e-07	19	297	0.033	0.904	NS/NA
ESCA	Esophageal carcinoma	-0.499	0	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.197	0.115	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.363	0	20	522	0.012	0.589	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.054	0.317	24	319	0.003	0.0334	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.079	0.176	23	275	-0.01	0.362	NS/NA
LAML	Acute Myeloid Leukemia	-0.274	0.000316	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.077	0.0753	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.26	9.47e-08	41	373	-0.062	0.00108	NS/NA
LUAD	Lung adenocarcinoma	-0.224	8.39e-07	21	456	0.098	0.745	NS/NA
LUSC	Lung squamous cell carcinoma	-0.262	2.53e-07	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.567	0.121	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.191	0.00971	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.312	1.5e-05	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.11	0.0112	35	498	0	0.644	NS/NA
READ	Rectum adenocarcinoma	-0.322	0.00107	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.123	0.0468	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.147	0.00138	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.31	1.26e-09	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.309	9.13e-05	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.084	0.0483	50	509	-0.047	0.64	NS/NA
THYM	Thymoma	-0.418	2.06e-06	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.368	1.8e-16	34	431	-0.001	0.00013	NS/NA

Summary
Symbol	SCML2
Name	sex comb on midleg like 2 (Drosophila)
Aliases	sex comb on midleg (Drosophila)-like 2; Sex comb on midleg-like protein 2
Location	Xp22.13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	0	Not detected
Appendix	0	Not detected
Bone marrow	0	Not detected
Breast	1	Low
Bronchus	1	Low
Caudate	0	Not detected
Cerebellum	0	Not detected
Cerebral cortex	0	Not detected
Cervix, uterine	2	Medium
Colon	2	Medium
Duodenum	0	Not detected
Endometrium	0	Not detected
Epididymis	0	Not detected
Esophagus	2	Medium
Fallopian tube	1	Low
Gallbladder	0	Not detected
Heart muscle	0	Not detected
Hippocampus	0	Not detected
Kidney	1	Low
Liver	0	Not detected
Lung	1	Low
Lymph node	0	Not detected
Nasopharynx	0	Not detected
Oral mucosa	2	Medium
Ovary	0	Not detected
Pancreas	0	Not detected
Parathyroid gland	0	Not detected
Placenta	0	Not detected
Prostate	0	Not detected
Rectum	2	Medium
Salivary gland	0	Not detected
Seminal vesicle	0	Not detected
Skeletal muscle	0	Not detected
Skin	0	Not detected
Small intestine	1	Low
Smooth muscle	0	Not detected
Soft tissue	0	Not detected
Spleen	0	Not detected
Stomach	0	Not detected
Testis	2	Medium
Thyroid gland	2	Medium
Tonsil	0	Not detected
Urinary bladder	0	Not detected
Vagina	2	Medium

Summary
Symbol	SCML2
Name	sex comb on midleg like 2 (Drosophila)
Aliases	sex comb on midleg (Drosophila)-like 2; Sex comb on midleg-like protein 2
Location	Xp22.13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.0688	NS	24476821
BRCA	Breast invasive carcinoma	521	8.2e-25	Significant	23000897
COAD	Colon adenocarcinoma	149	0.0052	Significant	22810696
GBM	Glioblastoma multiforme	157	4.98e-06	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	8.41e-17	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	6.34e-05	Significant	26536169
LGG	Brain Lower Grade Glioma	513	1.33e-41	Significant	26824661
LUAD	Lung adenocarcinoma	230	9.16e-08	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	4.67e-10	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	9.27e-09	Significant	21720365
PRAD	Prostate adenocarcinoma	333	0.314	NS	26544944
READ	Rectum adenocarcinoma	67	0.00232	Significant	22810696
SKCM	Skin Cutaneous Melanoma	315	0.145	NS	26091043
STAD	Stomach adenocarcinoma	277	5.79e-07	Significant	25079317
THCA	Thyroid carcinoma	391	2.43e-25	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	3.71e-06	Significant	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	1.608	0.0395	Shorter
BRCA	Breast invasive carcinoma	1079	0.761	0.238	NS
CESC	Cervical and endocervical cancers	291	0.593	0.116	NS
COAD	Colon adenocarcinoma	439	1.244	0.469	NS
ESCA	Esophageal carcinoma	184	1.531	0.149	NS
GBM	Glioblastoma multiforme	158	0.715	0.181	NS
HNSC	Head and Neck squamous cell carcinoma	518	0.7	0.0651	NS
KIRC	Kidney renal clear cell carcinoma	531	1.525	0.0398	Shorter
KIRP	Kidney renal papillary cell carcinoma	287	2.722	0.0144	Shorter
LAML	Acute Myeloid Leukemia	149	1.025	0.923	NS
LGG	Brain Lower Grade Glioma	511	0.621	0.0707	NS
LIHC	Liver hepatocellular carcinoma	365	1.913	0.00701	Shorter
LUAD	Lung adenocarcinoma	502	1.398	0.111	NS
LUSC	Lung squamous cell carcinoma	494	0.727	0.0941	NS
OV	Ovarian serous cystadenocarcinoma	303	1.233	0.321	NS
PAAD	Pancreatic adenocarcinoma	177	0.336	0.000785	Longer
PCPG	Pheochromocytoma and Paraganglioma	179	2.622	0.42	NS
PRAD	Prostate adenocarcinoma	497	0.872	0.86	NS
READ	Rectum adenocarcinoma	159	0.824	0.72	NS
SARC	Sarcoma	259	1.588	0.0984	NS
SKCM	Skin Cutaneous Melanoma	459	1.001	0.995	NS
STAD	Stomach adenocarcinoma	388	1.077	0.747	NS
TGCT	Testicular Germ Cell Tumors	134	0	0.283	NS
THCA	Thyroid carcinoma	500	1.411	0.556	NS
THYM	Thymoma	119	0	0.011	Longer
UCEC	Uterine Corpus Endometrial Carcinoma	543	2.221	0.00822	Shorter

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	0.187	0.000151	Higher
BRCA	Breast invasive carcinoma	1071	-0.025	0.406	NS
CESC	Cervical and endocervical cancers	167	0.053	0.499	NS
COAD	Colon adenocarcinoma	445	0.042	0.373	NS
ESCA	Esophageal carcinoma	162	-0.04	0.616	NS
HNSC	Head and Neck squamous cell carcinoma	448	0.071	0.134	NS
KIRC	Kidney renal clear cell carcinoma	531	0.118	0.0067	Higher
KIRP	Kidney renal papillary cell carcinoma	260	0.236	0.000118	Higher
LIHC	Liver hepatocellular carcinoma	347	0.032	0.554	NS
LUAD	Lung adenocarcinoma	507	0.047	0.294	NS
LUSC	Lung squamous cell carcinoma	497	0.095	0.035	Higher
OV	Ovarian serous cystadenocarcinoma	302	-0.015	0.8	NS
PAAD	Pancreatic adenocarcinoma	176	-0.254	0.000655	Lower
READ	Rectum adenocarcinoma	156	0.113	0.158	NS
SKCM	Skin Cutaneous Melanoma	410	-0.056	0.259	NS
STAD	Stomach adenocarcinoma	392	-0.014	0.781	NS
TGCT	Testicular Germ Cell Tumors	81	0.151	0.177	NS
THCA	Thyroid carcinoma	499	-0.167	0.000178	Lower
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.178	5.91e-05	Higher

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	0.051	0.4	NS
HNSC	Head and Neck squamous cell carcinoma	498	0.154	0.000551	Higher
KIRC	Kidney renal clear cell carcinoma	525	0.098	0.024	Higher
LGG	Brain Lower Grade Glioma	514	-0.017	0.704	NS
LIHC	Liver hepatocellular carcinoma	366	0.162	0.00193	Higher
OV	Ovarian serous cystadenocarcinoma	296	0.114	0.051	NS
PAAD	Pancreatic adenocarcinoma	176	-0.179	0.0175	Lower
STAD	Stomach adenocarcinoma	406	-0.079	0.114	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.309	2.71e-13	Higher

Summary
Symbol	SCML2
Name	sex comb on midleg like 2 (Drosophila)
Aliases	sex comb on midleg (Drosophila)-like 2; Sex comb on midleg-like protein 2
Location	Xp22.13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	SCML2
Name	sex comb on midleg like 2 (Drosophila)
Aliases	sex comb on midleg (Drosophila)-like 2; Sex comb on midleg-like protein 2
Location	Xp22.13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for SCML2.

Summary
Symbol	SCML2
Name	sex comb on midleg like 2 (Drosophila)
Aliases	sex comb on midleg (Drosophila)-like 2; Sex comb on midleg-like protein 2
Location	Xp22.13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining [ TOP ]
There is no record for SCML2.