CR2Cancer

Summary
Symbol	SIRT2
Name	sirtuin 2
Aliases	SIR2L; sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 2; sirtuin (silent matin ......
Location	19q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

[ TOP ]

Domain

PF02146 Sir2 family

Function

NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and alpha-tubulin as well as many other proteins such as key transcription factors. Participates in the modulation of multiple and diverse biological processes such as cell cycle control, genomic integrity, microtubule dynamics, cell differentiation, metabolic networks, and autophagy. Plays a major role in the control of cell cycle progression and genomic stability. Functions in the antephase checkpoint preventing precocious mitotic entry in response to microtubule stress agents, and hence allowing proper inheritance of chromosomes. Positively regulates the anaphase promoting complex/cyclosome (APC/C) ubiquitin ligase complex activity by deacetylating CDC20 and FZR1, then allowing progression through mitosis. Associates both with chromatin at transcriptional start sites (TSSs) and enhancers of active genes. Plays a role in cell cycle and chromatin compaction through epigenetic modulation of the regulation of histone H4 'Lys-20' methylation (H4K20me1) during early mitosis. Specifically deacetylates histone H4 at 'Lys-16' (H4K16ac) between the G2/M transition and metaphase enabling H4K20me1 deposition by KMT5A leading to ulterior levels of H4K20me2 and H4K20me3 deposition throughout cell cycle, and mitotic S-phase progression. Deacetylates KMT5A modulating KMT5A chromatin localization during the mitotic stress response. Deacetylates also histone H3 at 'Lys-57' (H3K56ac) during the mitotic G2/M transition. Upon bacterium Listeria monocytogenes infection, deacetylates 'Lys-18' of histone H3 in a receptor tyrosine kinase MET- and PI3K/Akt-dependent manner, thereby inhibiting transcriptional activity and promoting late stages of listeria infection. During oocyte meiosis progression, may deacetylate histone H4 at 'Lys-16' (H4K16ac) and alpha-tubulin, regulating spindle assembly and chromosome alignment by influencing microtubule dynamics and kinetochore function. Deacetylates alpha-tubulin at 'Lys-40' and hence controls neuronal motility, oligodendroglial cell arbor projection processes and proliferation of non-neuronal cells. Phosphorylation at Ser-368 by a G1/S-specific cyclin E-CDK2 complex inactivates SIRT2-mediated alpha-tubulin deacetylation, negatively regulating cell adhesion, cell migration and neurite outgrowth during neuronal differentiation. Deacetylates PARD3 and participates in the regulation of Schwann cell peripheral myelination formation during early postnatal development and during postinjury remyelination. Involved in several cellular metabolic pathways. Plays a role in the regulation of blood glucose homeostasis by deacetylating and stabilizing phosphoenolpyruvate carboxykinase PCK1 activity in response to low nutrient availability. Acts as a key regulator in the pentose phosphate pathway (PPP) by deacetylating and activating the glucose-6-phosphate G6PD enzyme, and therefore, stimulates the production of cytosolic NADPH to counteract oxidative damage. Maintains energy homeostasis in response to nutrient deprivation as well as energy expenditure by inhibiting adipogenesis and promoting lipolysis. Attenuates adipocyte differentiation by deacetylating and promoting FOXO1 interaction to PPARG and subsequent repression of PPARG-dependent transcriptional activity. Plays a role in the regulation of lysosome-mediated degradation of protein aggregates by autophagy in neuronal cells. Deacetylates FOXO1 in response to oxidative stress or serum deprivation, thereby negatively regulating FOXO1-mediated autophagy. Deacetylates a broad range of transcription factors and co-regulators regulating target gene expression. Deacetylates transcriptional factor FOXO3 stimulating the ubiquitin ligase SCF(SKP2)-mediated FOXO3 ubiquitination and degradation. Deacetylates HIF1A and therefore promotes HIF1A degradation and inhibition of HIF1A transcriptional activity in tumor cells in response to hypoxia. Deacetylates RELA in the cytoplasm inhibiting NF-kappaB-dependent transcription activation upon TNF-alpha stimulation. Inhibits transcriptional activation by deacetylating p53/TP53 and EP300. Deacetylates also EIF5A. Functions as a negative regulator on oxidative stress-tolerance in response to anoxia-reoxygenation conditions. Plays a role as tumor suppressor.; FUNCTION: Isoform 1: Deacetylates EP300, alpha-tubulin and histone H3 and H4.; FUNCTION: Isoform 2: Deacetylates EP300, alpha-tubulin and histone H3 and H4.; FUNCTION: Isoform 5: Lacks deacetylation activity.

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification erase, Histone modification write cofactor	Histone acetylation, Histone methylation	H3K18ac, H3K56ac, H4K16ac, H4K20me1	H3K18, H3K56, H4K16, H4K20me2, H4K20me3	11427894

> Gene Ontology [ TOP ]
Biological Process	GO:0000183 chromatin silencing at rDNA GO:0001556 oocyte maturation GO:0001666 response to hypoxia GO:0001933 negative regulation of protein phosphorylation GO:0002237 response to molecule of bacterial origin GO:0002831 regulation of response to biotic stimulus GO:0002832 negative regulation of response to biotic stimulus GO:0006342 chromatin silencing GO:0006348 chromatin silencing at telomere GO:0006471 protein ADP-ribosylation GO:0006476 protein deacetylation GO:0006486 protein glycosylation GO:0006914 autophagy GO:0006979 response to oxidative stress GO:0007059 chromosome segregation GO:0007067 mitotic nuclear division GO:0007088 regulation of mitotic nuclear division GO:0007096 regulation of exit from mitosis GO:0007126 meiotic nuclear division GO:0007272 ensheathment of neurons GO:0007281 germ cell development GO:0007292 female gamete generation GO:0007346 regulation of mitotic cell cycle GO:0007422 peripheral nervous system development GO:0007517 muscle organ development GO:0008366 axon ensheathment GO:0008608 attachment of spindle microtubules to kinetochore GO:0009100 glycoprotein metabolic process GO:0009101 glycoprotein biosynthetic process GO:0009894 regulation of catabolic process GO:0009895 negative regulation of catabolic process GO:0009896 positive regulation of catabolic process GO:0009991 response to extracellular stimulus GO:0009994 oocyte differentiation GO:0010001 glial cell differentiation GO:0010458 exit from mitosis GO:0010498 proteasomal protein catabolic process GO:0010506 regulation of autophagy GO:0010507 negative regulation of autophagy GO:0010720 positive regulation of cell development GO:0010721 negative regulation of cell development GO:0010799 regulation of peptidyl-threonine phosphorylation GO:0010801 negative regulation of peptidyl-threonine phosphorylation GO:0014013 regulation of gliogenesis GO:0014014 negative regulation of gliogenesis GO:0014037 Schwann cell differentiation GO:0014044 Schwann cell development GO:0014065 phosphatidylinositol 3-kinase signaling GO:0014706 striated muscle tissue development GO:0016042 lipid catabolic process GO:0016202 regulation of striated muscle tissue development GO:0016458 gene silencing GO:0016570 histone modification GO:0016575 histone deacetylation GO:0018107 peptidyl-threonine phosphorylation GO:0018205 peptidyl-lysine modification GO:0018210 peptidyl-threonine modification GO:0021700 developmental maturation GO:0021762 substantia nigra development GO:0021782 glial cell development GO:0022011 myelination in peripheral nervous system GO:0022412 cellular process involved in reproduction in multicellular organism GO:0030901 midbrain development GO:0031329 regulation of cellular catabolic process GO:0031331 positive regulation of cellular catabolic process GO:0031333 negative regulation of protein complex assembly GO:0031348 negative regulation of defense response GO:0031641 regulation of myelination GO:0031667 response to nutrient levels GO:0032102 negative regulation of response to external stimulus GO:0032292 peripheral nervous system axon ensheathment GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0034599 cellular response to oxidative stress GO:0034983 peptidyl-lysine deacetylation GO:0035601 protein deacylation GO:0035728 response to hepatocyte growth factor GO:0035729 cellular response to hepatocyte growth factor stimulus GO:0036293 response to decreased oxygen levels GO:0036294 cellular response to decreased oxygen levels GO:0040020 regulation of meiotic nuclear division GO:0040029 regulation of gene expression, epigenetic GO:0042063 gliogenesis GO:0042176 regulation of protein catabolic process GO:0042177 negative regulation of protein catabolic process GO:0042326 negative regulation of phosphorylation GO:0042552 myelination GO:0042742 defense response to bacterium GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043254 regulation of protein complex assembly GO:0043388 positive regulation of DNA binding GO:0043413 macromolecule glycosylation GO:0043491 protein kinase B signaling GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress GO:0043620 regulation of DNA-templated transcription in response to stress GO:0043900 regulation of multi-organism process GO:0043901 negative regulation of multi-organism process GO:0043902 positive regulation of multi-organism process GO:0044242 cellular lipid catabolic process GO:0044546 NLRP3 inflammasome complex assembly GO:0044770 cell cycle phase transition GO:0044772 mitotic cell cycle phase transition GO:0045444 fat cell differentiation GO:0045598 regulation of fat cell differentiation GO:0045599 negative regulation of fat cell differentiation GO:0045732 positive regulation of protein catabolic process GO:0045787 positive regulation of cell cycle GO:0045814 negative regulation of gene expression, epigenetic GO:0045836 positive regulation of meiotic nuclear division GO:0045843 negative regulation of striated muscle tissue development GO:0045862 positive regulation of proteolysis GO:0048012 hepatocyte growth factor receptor signaling pathway GO:0048015 phosphatidylinositol-mediated signaling GO:0048017 inositol lipid-mediated signaling GO:0048469 cell maturation GO:0048477 oogenesis GO:0048599 oocyte development GO:0048634 regulation of muscle organ development GO:0048635 negative regulation of muscle organ development GO:0048857 neural nucleus development GO:0050768 negative regulation of neurogenesis GO:0051098 regulation of binding GO:0051099 positive regulation of binding GO:0051101 regulation of DNA binding GO:0051302 regulation of cell division GO:0051321 meiotic cell cycle GO:0051445 regulation of meiotic cell cycle GO:0051446 positive regulation of meiotic cell cycle GO:0051775 response to redox state GO:0051781 positive regulation of cell division GO:0051783 regulation of nuclear division GO:0051785 positive regulation of nuclear division GO:0051961 negative regulation of nervous system development GO:0051983 regulation of chromosome segregation GO:0051984 positive regulation of chromosome segregation GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore GO:0051988 regulation of attachment of spindle microtubules to kinetochore GO:0060281 regulation of oocyte development GO:0060282 positive regulation of oocyte development GO:0060537 muscle tissue development GO:0061136 regulation of proteasomal protein catabolic process GO:0061351 neural precursor cell proliferation GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061428 negative regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061433 cellular response to caloric restriction GO:0061771 response to caloric restriction GO:0070085 glycosylation GO:0070265 necrotic cell death GO:0070266 necroptotic process GO:0070444 oligodendrocyte progenitor proliferation GO:0070445 regulation of oligodendrocyte progenitor proliferation GO:0070446 negative regulation of oligodendrocyte progenitor proliferation GO:0070482 response to oxygen levels GO:0070932 histone H3 deacetylation GO:0070933 histone H4 deacetylation GO:0071216 cellular response to biotic stimulus GO:0071219 cellular response to molecule of bacterial origin GO:0071407 cellular response to organic cyclic compound GO:0071417 cellular response to organonitrogen compound GO:0071453 cellular response to oxygen levels GO:0071456 cellular response to hypoxia GO:0071867 response to monoamine GO:0071868 cellular response to monoamine stimulus GO:0071869 response to catecholamine GO:0071870 cellular response to catecholamine stimulus GO:0071871 response to epinephrine GO:0071872 cellular response to epinephrine stimulus GO:0072593 reactive oxygen species metabolic process GO:0090042 tubulin deacetylation GO:0090068 positive regulation of cell cycle process GO:0097194 execution phase of apoptosis GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress GO:0097300 programmed necrotic cell death GO:0097343 ripoptosome assembly GO:0098542 defense response to other organism GO:0098732 macromolecule deacylation GO:0098813 nuclear chromosome segregation GO:1900117 regulation of execution phase of apoptosis GO:1900119 positive regulation of execution phase of apoptosis GO:1900193 regulation of oocyte maturation GO:1900195 positive regulation of oocyte maturation GO:1900225 regulation of NLRP3 inflammasome complex assembly GO:1900226 negative regulation of NLRP3 inflammasome complex assembly GO:1900424 regulation of defense response to bacterium GO:1900425 negative regulation of defense response to bacterium GO:1901026 ripoptosome assembly involved in necroptotic process GO:1901800 positive regulation of proteasomal protein catabolic process GO:1901861 regulation of muscle tissue development GO:1901862 negative regulation of muscle tissue development GO:1901987 regulation of cell cycle phase transition GO:1901990 regulation of mitotic cell cycle phase transition GO:1903046 meiotic cell cycle process GO:1903050 regulation of proteolysis involved in cellular protein catabolic process GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process GO:1903362 regulation of cellular protein catabolic process GO:1903364 positive regulation of cellular protein catabolic process GO:1903429 regulation of cell maturation GO:1903431 positive regulation of cell maturation GO:2000177 regulation of neural precursor cell proliferation GO:2000178 negative regulation of neural precursor cell proliferation GO:2000241 regulation of reproductive process GO:2000243 positive regulation of reproductive process GO:2000377 regulation of reactive oxygen species metabolic process GO:2000378 negative regulation of reactive oxygen species metabolic process GO:2000777 positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia
Molecular Function	GO:0003682 chromatin binding GO:0004407 histone deacetylase activity GO:0008134 transcription factor binding GO:0015631 tubulin binding GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides GO:0017136 NAD-dependent histone deacetylase activity GO:0019213 deacetylase activity GO:0032182 ubiquitin-like protein binding GO:0033558 protein deacetylase activity GO:0034739 histone deacetylase activity (H4-K16 specific) GO:0034979 NAD-dependent protein deacetylase activity GO:0035035 histone acetyltransferase binding GO:0042826 histone deacetylase binding GO:0042903 tubulin deacetylase activity GO:0043130 ubiquitin binding GO:0046970 NAD-dependent histone deacetylase activity (H4-K16 specific) GO:0048037 cofactor binding GO:0048487 beta-tubulin binding GO:0050662 coenzyme binding GO:0051287 NAD binding GO:0070403 NAD+ binding
Cellular Component	GO:0000781 chromosome, telomeric region GO:0000785 chromatin GO:0000790 nuclear chromatin GO:0000792 heterochromatin GO:0005677 chromatin silencing complex GO:0005720 nuclear heterochromatin GO:0005813 centrosome GO:0005814 centriole GO:0005819 spindle GO:0005874 microtubule GO:0017053 transcriptional repressor complex GO:0030424 axon GO:0030426 growth cone GO:0030427 site of polarized growth GO:0030496 midbody GO:0033010 paranodal junction GO:0033267 axon part GO:0033270 paranode region of axon GO:0043025 neuronal cell body GO:0043204 perikaryon GO:0043209 myelin sheath GO:0043218 compact myelin GO:0043219 lateral loop GO:0043220 Schmidt-Lanterman incisure GO:0044224 juxtaparanode region of axon GO:0044297 cell body GO:0044304 main axon GO:0044450 microtubule organizing center part GO:0044454 nuclear chromosome part GO:0072686 mitotic spindle GO:0072687 meiotic spindle GO:0090568 nuclear transcriptional repressor complex GO:0097386 glial cell projection GO:0098687 chromosomal region

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	-

Summary
Symbol	SIRT2
Name	sirtuin 2
Aliases	SIR2L; sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 2; sirtuin (silent matin ......
Location	19q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

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COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM5938435	c.748-8C>T	p.?	Unknown	Skin
COSM5389692	c.932_933CC>TT	p.S311F	Substitution - Missense	Skin
COSM292457	c.85G>A	p.G29R	Substitution - Missense	Large_intestine
COSM315203	c.654G>A	p.T218T	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM5950978	c.229C>T	p.R77C	Substitution - Missense	Prostate
COSM4077878	c.607G>A	p.E203K	Substitution - Missense	Stomach
COSM5914196	c.825-8C>T	p.?	Unknown	Skin
COSM996180	c.585C>T	p.C195C	Substitution - coding silent	Large_intestine
COSM1712249	c.803_804CC>TT	p.P268L	Substitution - Missense	Skin
COSM4077878	c.607G>A	p.E203K	Substitution - Missense	Biliary_tract
COSM5972926	c.768C>G	p.L256L	Substitution - coding silent	Upper_aerodigestive_tract
COSM3422784	c.1164C>A	p.P388P	Substitution - coding silent	Large_intestine
COSM439448	c.756G>A	p.L252L	Substitution - coding silent	Breast
COSM1393477	c.586G>A	p.V196I	Substitution - Missense	Large_intestine
COSM996178	c.951C>T	p.D317D	Substitution - coding silent	Endometrium
COSM5056619	c.601C>T	p.R201W	Substitution - Missense	Stomach
COSM4077880	c.397G>A	p.A133T	Substitution - Missense	Stomach
COSM4077880	c.397G>A	p.A133T	Substitution - Missense	Stomach
COSM3404205	c.705T>G	p.F235L	Substitution - Missense	Central_nervous_system
COSM5645185	c.416A>G	p.Y139C	Substitution - Missense	Oesophagus
COSM3707124	c.269-8T>A	p.?	Unknown	Liver
COSM389292	c.948-2A>T	p.?	Unknown	Lung
COSM4843633	c.911G>A	p.G304E	Substitution - Missense	Cervix
COSM3533597	c.120C>T	p.F40F	Substitution - coding silent	Skin
COSM5056621	c.384G>A	p.P128P	Substitution - coding silent	Stomach
COSM996177	c.1021C>A	p.L341M	Substitution - Missense	Endometrium
COSM4657196	c.725G>A	p.R242H	Substitution - Missense	Large_intestine
COSM4449026	c.16+1G>C	p.?	Unknown	Skin
COSM5923333	c.269-5C>T	p.?	Unknown	Skin
COSM996182	c.457C>T	p.R153C	Substitution - Missense	Large_intestine
COSM5150166	c.1143G>A	p.R381R	Substitution - coding silent	Large_intestine
COSM711534	c.125G>C	p.R42P	Substitution - Missense	Lung
COSM996182	c.457C>T	p.R153C	Substitution - Missense	Large_intestine
COSM1393476	c.1074G>A	p.A358A	Substitution - coding silent	Large_intestine
COSM5056620	c.591C>T	p.S197S	Substitution - coding silent	Stomach
COSM1180424	c.718C>A	p.P240T	Substitution - Missense	Prostate
COSM4581009	c.145C>A	p.L49I	Substitution - Missense	Bone
COSM4457848	c.1062C>T	p.A354A	Substitution - coding silent	Skin
COSM3223119	c.1073C>T	p.A358V	Substitution - Missense	Large_intestine
COSM5824872	c.1110G>T	p.K370N	Substitution - Missense	Pancreas
COSM5464567	c.169C>T	p.R57C	Substitution - Missense	Large_intestine
COSM996179	c.608A>G	p.E203G	Substitution - Missense	Endometrium
COSM3742938	c.454A>G	p.M152V	Substitution - Missense	Liver
COSM233368	c.697G>A	p.V233I	Substitution - Missense	Lung
COSM1612208	c.226+8C>T	p.?	Unknown	Liver
COSM4400092	c.753C>T	p.F251F	Substitution - coding silent	Skin
COSM996184	c.383C>T	p.P128L	Substitution - Missense	Large_intestine
COSM4393539	c.497C>T	p.T166M	Substitution - Missense	Prostate
COSM5563537	c.876G>T	p.Q292H	Substitution - Missense	Prostate
COSM1481025	c.1036C>T	p.R346W	Substitution - Missense	Breast
COSM5800026	c.738T>A	p.C246*	Substitution - Nonsense	Breast
COSM4929388	c.250G>A	p.G84R	Substitution - Missense	Liver
COSM711535	c.219C>A	p.S73R	Substitution - Missense	Lung
COSM996180	c.585C>T	p.C195C	Substitution - coding silent	Endometrium
COSM3533596	c.234A>G	p.R78R	Substitution - coding silent	Skin
COSM996185	c.94G>A	p.A32T	Substitution - Missense	Large_intestine
COSM996184	c.383C>T	p.P128L	Substitution - Missense	Endometrium
COSM4490439	c.363C>T	p.I121I	Substitution - coding silent	Skin
COSM4077879	c.402C>T	p.L134L	Substitution - coding silent	Stomach
COSM4077880	c.397G>A	p.A133T	Substitution - Missense	Stomach
COSM711536	c.529G>T	p.G177W	Substitution - Missense	Lung
COSM996183	c.419C>A	p.P140H	Substitution - Missense	Endometrium
COSM5113192	c.501+6C>T	p.?	Unknown	Large_intestine
COSM5188217	c.113-6G>A	p.?	Unknown	Large_intestine
COSM5780440	c.325A>C	p.K109Q	Substitution - Missense	Breast
COSM315203	c.654G>A	p.T218T	Substitution - coding silent	Lung
COSM4485748	c.296C>T	p.P99L	Substitution - Missense	Skin
COSM3707124	c.269-8T>A	p.?	Unknown	Liver
COSM1190035	c.1156G>T	p.E386*	Substitution - Nonsense	Lung
COSM996181	c.557C>T	p.A186V	Substitution - Missense	Endometrium
COSM996185	c.94G>A	p.A32T	Substitution - Missense	Large_intestine
COSM1612208	c.226+8C>T	p.?	Unknown	Liver
COSM4726196	c.906C>T	p.G302G	Substitution - coding silent	Large_intestine
COSM233368	c.697G>A	p.V233I	Substitution - Missense	Skin
COSM996185	c.94G>A	p.A32T	Substitution - Missense	Endometrium
COSM996182	c.457C>T	p.R153C	Substitution - Missense	Endometrium
COSM3533595	c.453C>T	p.F151F	Substitution - coding silent	Skin
COSM4726197	c.639C>G	p.I213M	Substitution - Missense	Large_intestine
COSM5056622	c.15C>T	p.D5D	Substitution - coding silent	Stomach
COSM5056618	c.1120C>T	p.P374S	Substitution - Missense	Stomach

> Text Mining based Variations [ TOP ]
There is no record for SIRT2.

Summary
Symbol	SIRT2
Name	sirtuin 2
Aliases	SIR2L; sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 2; sirtuin (silent matin ......
Location	19q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

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Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
Q8IXJ6	23	S	Phosphoserine	-	No	None detected
Q8IXJ6	25	S	Phosphoserine	-	No	None detected
Q8IXJ6	27	S	Phosphoserine	-	No	None detected
Q8IXJ6	53	S	Phosphoserine	-	No	None detected
Q8IXJ6	100	S	Phosphoserine	-	No	None detected
Q8IXJ6	207	S	Phosphoserine	-	No	None detected
Q8IXJ6	368	S	Phosphoserine	CDK2 and CDK5	No	None detected
Q8IXJ6	372	S	Phosphoserine	-	No	None detected

Summary
Symbol	SIRT2
Name	sirtuin 2
Aliases	SIR2L; sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 2; sirtuin (silent matin ......
Location	19q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

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Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	6.157	5.886	-0.144	0.375	NS
BRCA	Breast invasive carcinoma	112	1100	5.892	5.585	-0.32	9.18e-10	NS
CESC	Cervical and endocervical cancers	3	306	6.246	5.75	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	5.535	5.447	-0.17	0.0184	NS
ESCA	Esophageal carcinoma	11	185	5.74	5.481	-0.32	0.136	NS
GBM	Glioblastoma multiforme	5	166	7.715	7.487	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	6.069	5.577	-0.734	4.61e-16	Under
KIRC	Kidney renal clear cell carcinoma	72	534	5.647	6.1	0.476	5.49e-22	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	5.976	5.735	-0.157	0.087	NS
LAML	Acute Myeloid Leukemia	0	173	NA	5.433	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	8.145	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	5.595	5.55	-0.073	0.422	NS
LUAD	Lung adenocarcinoma	59	517	5.862	5.545	-0.348	1.12e-06	NS
LUSC	Lung squamous cell carcinoma	51	501	5.943	5.837	-0.068	0.46	NS
OV	Ovarian serous cystadenocarcinoma	0	307	NA	5.853	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	5.64	5.624	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	6.035	5.925	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	5.768	5.893	0.141	0.0103	NS
READ	Rectum adenocarcinoma	10	167	5.551	5.438	-0.077	0.678	NS
SARC	Sarcoma	2	263	6.449	6.289	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	6.074	6.226	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	6.187	5.489	-0.704	3.67e-12	Under
TGCT	Testicular Germ Cell Tumors	0	156	NA	4.794	NA	NA	NA
THCA	Thyroid carcinoma	59	509	5.786	5.973	0.208	0.000213	NS
THYM	Thymoma	2	120	5.776	6.026	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	5.995	5.519	-0.478	1.02e-06	NS

> Cancer Cell Line Encyclopedia (CCLE)

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Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	7.6
Autonomic ganglia	CHP212	7.1
Autonomic ganglia	IMR32	6.8
Autonomic ganglia	KELLY	7.6
Autonomic ganglia	KPNRTBM1	7.3
Autonomic ganglia	KPNSI9S	7.3
Autonomic ganglia	KPNYN	7.6
Autonomic ganglia	MHHNB11	7
Autonomic ganglia	NB1	7.8
Autonomic ganglia	NH6	7.7
Autonomic ganglia	SHSY5Y	7
Autonomic ganglia	SIMA	7.1
Autonomic ganglia	SKNAS	7.8
Autonomic ganglia	SKNBE2	6.9
Autonomic ganglia	SKNDZ	6.8
Autonomic ganglia	SKNFI	7.3
Autonomic ganglia	SKNSH	7.2
Biliary tract	HUCCT1	7.5
Biliary tract	HUH28	7.8
Biliary tract	SNU1079	7.9
Biliary tract	SNU1196	7
Biliary tract	SNU245	7.3
Biliary tract	SNU308	7.1
Biliary tract	SNU478	7.7
Bone	143B	6.9
Bone	A673	7.8
Bone	CADOES1	7.5
Bone	CAL78	8.5
Bone	G292CLONEA141B1	7.4
Bone	HOS	7.1
Bone	HS706T	7.6
Bone	HS737T	8.4
Bone	HS819T	7.9
Bone	HS821T	7.6
Bone	HS822T	8.2
Bone	HS863T	8
Bone	HS870T	8.1
Bone	HS888T	7.6
Bone	MG63	8.1
Bone	MHHES1	7.3
Bone	OUMS27	7.5
Bone	RDES	7
Bone	SJSA1	7.9
Bone	SKES1	7.4
Bone	SKNMC	7.5
Bone	SW1353	7.6
Bone	T173	8
Bone	TC71	7.5
Bone	U2OS	6.9
Breast	AU565	7.7
Breast	BT20	7.9
Breast	BT474	7.9
Breast	BT483	7.7
Breast	BT549	8.3
Breast	CAL120	7.5
Breast	CAL148	7.6
Breast	CAL51	7.1
Breast	CAL851	8.7
Breast	CAMA1	7.9
Breast	DU4475	7.1
Breast	EFM192A	8.6
Breast	EFM19	7.8
Breast	EVSAT	8.5
Breast	HCC1143	7.3
Breast	HCC1187	8
Breast	HCC1395	7.8
Breast	HCC1419	8.7
Breast	HCC1428	7.1
Breast	HCC1500	7.7
Breast	HCC1569	8.2
Breast	HCC1599	7.8
Breast	HCC1806	7.8
Breast	HCC1937	7.9
Breast	HCC1954	7.6
Breast	HCC202	8.1
Breast	HCC2157	7.5
Breast	HCC2218	8.2
Breast	HCC38	7.3
Breast	HCC70	8
Breast	HDQP1	6.9
Breast	HMC18	7.2
Breast	HS274T	7.6
Breast	HS281T	7.9
Breast	HS343T	7.8
Breast	HS578T	8.3
Breast	HS606T	7.8
Breast	HS739T	8.1
Breast	HS742T	7.7
Breast	JIMT1	7.9
Breast	KPL1	7.3
Breast	MCF7	7.7
Breast	MDAMB134VI	7.5
Breast	MDAMB157	8.7
Breast	MDAMB175VII	7.9
Breast	MDAMB231	8.1
Breast	MDAMB361	7.2
Breast	MDAMB415	8.1
Breast	MDAMB436	7.3
Breast	MDAMB453	7.9
Breast	MDAMB468	8
Breast	SKBR3	8.1
Breast	T47D	7.3
Breast	UACC812	8.4
Breast	UACC893	7.1
Breast	YMB1	7.7
Breast	ZR751	7.6
Breast	ZR7530	8.1
Central nervous system	1321N1	7.6
Central nervous system	42MGBA	7.6
Central nervous system	8MGBA	7.8
Central nervous system	A172	8
Central nervous system	AM38	7.4
Central nervous system	BECKER	7.8
Central nervous system	CAS1	8.3
Central nervous system	CCFSTTG1	8.1
Central nervous system	D283MED	7.4
Central nervous system	D341MED	7.8
Central nervous system	DAOY	6.8
Central nervous system	DBTRG05MG	7.8
Central nervous system	DKMG	6.9
Central nervous system	GAMG	7.1
Central nervous system	GB1	7.6
Central nervous system	GI1	7.9
Central nervous system	GMS10	7.2
Central nervous system	GOS3	8.5
Central nervous system	H4	7.4
Central nervous system	HS683	7.6
Central nervous system	KALS1	8.1
Central nervous system	KG1C	8.2
Central nervous system	KNS42	8.1
Central nervous system	KNS60	7.6
Central nervous system	KNS81	7.3
Central nervous system	KS1	7.3
Central nervous system	LN18	7.9
Central nervous system	LN229	7.1
Central nervous system	M059K	8.3
Central nervous system	MOGGCCM	8.6
Central nervous system	MOGGUVW	7
Central nervous system	NMCG1	7.3
Central nervous system	ONS76	7.7
Central nervous system	SF126	7.8
Central nervous system	SF295	8.3
Central nervous system	SNB19	9.1
Central nervous system	SNU1105	7.8
Central nervous system	SNU201	7.8
Central nervous system	SNU466	10.4
Central nervous system	SNU489	7.9
Central nervous system	SNU626	7.4
Central nervous system	SNU738	6.8
Central nervous system	SW1088	8
Central nervous system	SW1783	7.8
Central nervous system	T98G	7.8
Central nervous system	TM31	7.7
Central nervous system	U118MG	8
Central nervous system	U138MG	7.6
Central nervous system	U251MG	8.5
Central nervous system	U87MG	8
Central nervous system	YH13	8.9
Central nervous system	YKG1	7.6
Endometrium	AN3CA	8.4
Endometrium	COLO684	8.1
Endometrium	EFE184	7.7
Endometrium	EN	7.9
Endometrium	ESS1	7.3
Endometrium	HEC108	7.9
Endometrium	HEC151	7.3
Endometrium	HEC1A	7.6
Endometrium	HEC1B	8
Endometrium	HEC251	6.9
Endometrium	HEC265	7.4
Endometrium	HEC50B	6.7
Endometrium	HEC59	6.9
Endometrium	HEC6	7.5
Endometrium	ISHIKAWAHERAKLIO02ER	7
Endometrium	JHUEM1	7.5
Endometrium	JHUEM2	7.5
Endometrium	JHUEM3	7.1
Endometrium	KLE	10.8
Endometrium	MFE280	8.3
Endometrium	MFE296	8.2
Endometrium	MFE319	8.5
Endometrium	RL952	7.9
Endometrium	SNGM	7.5
Endometrium	SNU1077	8.2
Endometrium	SNU685	8.1
Endometrium	TEN	7.2
Haematopoietic and lymphoid	697	7.7
Haematopoietic and lymphoid	A3KAW	7.9
Haematopoietic and lymphoid	A4FUK	7.3
Haematopoietic and lymphoid	ALLSIL	7.6
Haematopoietic and lymphoid	AML193	7.4
Haematopoietic and lymphoid	AMO1	7.8
Haematopoietic and lymphoid	BCP1	8
Haematopoietic and lymphoid	BDCM	7.8
Haematopoietic and lymphoid	BL41	7.1
Haematopoietic and lymphoid	BL70	7.7
Haematopoietic and lymphoid	BV173	7.9
Haematopoietic and lymphoid	CA46	7.8
Haematopoietic and lymphoid	CI1	7.7
Haematopoietic and lymphoid	CMK115	7.7
Haematopoietic and lymphoid	CMK86	7.7
Haematopoietic and lymphoid	CMK	7.6
Haematopoietic and lymphoid	CMLT1	7.7
Haematopoietic and lymphoid	COLO775	8.3
Haematopoietic and lymphoid	DAUDI	7.4
Haematopoietic and lymphoid	DB	8.1
Haematopoietic and lymphoid	DEL	7.3
Haematopoietic and lymphoid	DND41	8.3
Haematopoietic and lymphoid	DOHH2	7.4
Haematopoietic and lymphoid	EB1	7.8
Haematopoietic and lymphoid	EB2	8.1
Haematopoietic and lymphoid	EHEB	7.2
Haematopoietic and lymphoid	EJM	8.3
Haematopoietic and lymphoid	EM2	8.1
Haematopoietic and lymphoid	EOL1	8.1
Haematopoietic and lymphoid	F36P	8.5
Haematopoietic and lymphoid	GA10	7.9
Haematopoietic and lymphoid	GDM1	7.7
Haematopoietic and lymphoid	GRANTA519	7
Haematopoietic and lymphoid	HDLM2	7.6
Haematopoietic and lymphoid	HDMYZ	8.1
Haematopoietic and lymphoid	HEL9217	7.4
Haematopoietic and lymphoid	HEL	7.2
Haematopoietic and lymphoid	HH	7.9
Haematopoietic and lymphoid	HL60	7.6
Haematopoietic and lymphoid	HPBALL	7.8
Haematopoietic and lymphoid	HS604T	8
Haematopoietic and lymphoid	HS611T	7.5
Haematopoietic and lymphoid	HS616T	7.8
Haematopoietic and lymphoid	HS751T	7.1
Haematopoietic and lymphoid	HT	7.5
Haematopoietic and lymphoid	HTK	7
Haematopoietic and lymphoid	HUNS1	7.8
Haematopoietic and lymphoid	HUT102	8.3
Haematopoietic and lymphoid	HUT78	7.7
Haematopoietic and lymphoid	JEKO1	7.3
Haematopoietic and lymphoid	JK1	7.6
Haematopoietic and lymphoid	JM1	8.1
Haematopoietic and lymphoid	JURKAT	7.8
Haematopoietic and lymphoid	JURLMK1	7.3
Haematopoietic and lymphoid	JVM2	7.3
Haematopoietic and lymphoid	JVM3	7.1
Haematopoietic and lymphoid	K562	8.3
Haematopoietic and lymphoid	KARPAS299	7.8
Haematopoietic and lymphoid	KARPAS422	6.8
Haematopoietic and lymphoid	KARPAS620	8
Haematopoietic and lymphoid	KASUMI1	6.9
Haematopoietic and lymphoid	KASUMI2	7.8
Haematopoietic and lymphoid	KASUMI6	7.4
Haematopoietic and lymphoid	KCL22	8
Haematopoietic and lymphoid	KE37	7.4
Haematopoietic and lymphoid	KE97	7.5
Haematopoietic and lymphoid	KG1	7.4
Haematopoietic and lymphoid	KHM1B	7.7
Haematopoietic and lymphoid	KIJK	7.8
Haematopoietic and lymphoid	KMH2	7.6
Haematopoietic and lymphoid	KMM1	8.6
Haematopoietic and lymphoid	KMS11	7.7
Haematopoietic and lymphoid	KMS12BM	8.2
Haematopoietic and lymphoid	KMS18	7.2
Haematopoietic and lymphoid	KMS20	6.4
Haematopoietic and lymphoid	KMS21BM	8.1
Haematopoietic and lymphoid	KMS26	8.2
Haematopoietic and lymphoid	KMS27	7.7
Haematopoietic and lymphoid	KMS28BM	7.4
Haematopoietic and lymphoid	KMS34	8
Haematopoietic and lymphoid	KO52	7.5
Haematopoietic and lymphoid	KOPN8	7.8
Haematopoietic and lymphoid	KU812	8
Haematopoietic and lymphoid	KYO1	8
Haematopoietic and lymphoid	L1236	8.1
Haematopoietic and lymphoid	L363	7.7
Haematopoietic and lymphoid	L428	7.7
Haematopoietic and lymphoid	L540	8
Haematopoietic and lymphoid	LAMA84	7.3
Haematopoietic and lymphoid	LOUCY	7.8
Haematopoietic and lymphoid	LP1	8
Haematopoietic and lymphoid	M07E	7.6
Haematopoietic and lymphoid	MC116	7.6
Haematopoietic and lymphoid	ME1	7.8
Haematopoietic and lymphoid	MEC1	7.1
Haematopoietic and lymphoid	MEC2	7.5
Haematopoietic and lymphoid	MEG01	8.1
Haematopoietic and lymphoid	MHHCALL2	6.9
Haematopoietic and lymphoid	MHHCALL3	7.7
Haematopoietic and lymphoid	MHHCALL4	7.6
Haematopoietic and lymphoid	MINO	7.3
Haematopoietic and lymphoid	MJ	8.1
Haematopoietic and lymphoid	MM1S	7.8
Haematopoietic and lymphoid	MOLM13	8
Haematopoietic and lymphoid	MOLM16	8
Haematopoietic and lymphoid	MOLM6	8
Haematopoietic and lymphoid	MOLP2	8
Haematopoietic and lymphoid	MOLP8	7.3
Haematopoietic and lymphoid	MOLT13	6.8
Haematopoietic and lymphoid	MOLT16	7.7
Haematopoietic and lymphoid	MOLT4	7.6
Haematopoietic and lymphoid	MONOMAC1	7.6
Haematopoietic and lymphoid	MONOMAC6	8
Haematopoietic and lymphoid	MOTN1	8.2
Haematopoietic and lymphoid	MUTZ5	7.7
Haematopoietic and lymphoid	MV411	8.5
Haematopoietic and lymphoid	NALM19	7.7
Haematopoietic and lymphoid	NALM1	7.6
Haematopoietic and lymphoid	NALM6	8.1
Haematopoietic and lymphoid	NAMALWA	7.7
Haematopoietic and lymphoid	NB4	6.7
Haematopoietic and lymphoid	NCIH929	8
Haematopoietic and lymphoid	NCO2	8
Haematopoietic and lymphoid	NOMO1	7.6
Haematopoietic and lymphoid	NUDHL1	8.4
Haematopoietic and lymphoid	NUDUL1	7.8
Haematopoietic and lymphoid	OCIAML2	7.7
Haematopoietic and lymphoid	OCIAML3	8.1
Haematopoietic and lymphoid	OCIAML5	7.4
Haematopoietic and lymphoid	OCILY10	7
Haematopoietic and lymphoid	OCILY19	7.8
Haematopoietic and lymphoid	OCILY3	7.5
Haematopoietic and lymphoid	OCIM1	8.1
Haematopoietic and lymphoid	OPM2	8.1
Haematopoietic and lymphoid	P12ICHIKAWA	7.5
Haematopoietic and lymphoid	P31FUJ	8.2
Haematopoietic and lymphoid	P3HR1	7.8
Haematopoietic and lymphoid	PCM6	8.5
Haematopoietic and lymphoid	PEER	8
Haematopoietic and lymphoid	PF382	7.4
Haematopoietic and lymphoid	PFEIFFER	7.3
Haematopoietic and lymphoid	PL21	7.9
Haematopoietic and lymphoid	RAJI	7.7
Haematopoietic and lymphoid	RCHACV	7.3
Haematopoietic and lymphoid	REC1	7.4
Haematopoietic and lymphoid	REH	7.9
Haematopoietic and lymphoid	RI1	8.5
Haematopoietic and lymphoid	RL	7.2
Haematopoietic and lymphoid	RPMI8226	7.6
Haematopoietic and lymphoid	RPMI8402	7.2
Haematopoietic and lymphoid	RS411	8.2
Haematopoietic and lymphoid	SEM	7.4
Haematopoietic and lymphoid	SET2	8.1
Haematopoietic and lymphoid	SIGM5	7.5
Haematopoietic and lymphoid	SKM1	8
Haematopoietic and lymphoid	SKMM2	7.8
Haematopoietic and lymphoid	SR786	7.5
Haematopoietic and lymphoid	ST486	8
Haematopoietic and lymphoid	SUDHL10	8
Haematopoietic and lymphoid	SUDHL1	8.3
Haematopoietic and lymphoid	SUDHL4	7.5
Haematopoietic and lymphoid	SUDHL5	6.8
Haematopoietic and lymphoid	SUDHL6	7.5
Haematopoietic and lymphoid	SUDHL8	7.5
Haematopoietic and lymphoid	SUPB15	7.7
Haematopoietic and lymphoid	SUPHD1	8
Haematopoietic and lymphoid	SUPM2	7
Haematopoietic and lymphoid	SUPT11	7.9
Haematopoietic and lymphoid	SUPT1	7.6
Haematopoietic and lymphoid	TALL1	7.4
Haematopoietic and lymphoid	TF1	7.9
Haematopoietic and lymphoid	THP1	7.7
Haematopoietic and lymphoid	TO175T	7.6
Haematopoietic and lymphoid	TOLEDO	7.4
Haematopoietic and lymphoid	U266B1	7.6
Haematopoietic and lymphoid	U937	8.8
Haematopoietic and lymphoid	UT7	8.1
Haematopoietic and lymphoid	WSUDLCL2	7.5
Kidney	769P	7.2
Kidney	786O	7.2
Kidney	A498	8.3
Kidney	A704	7.5
Kidney	ACHN	7.1
Kidney	BFTC909	6.9
Kidney	CAKI1	7.6
Kidney	CAKI2	8.2
Kidney	CAL54	6.9
Kidney	KMRC1	7.7
Kidney	KMRC20	8
Kidney	KMRC2	8
Kidney	KMRC3	8
Kidney	OSRC2	7.9
Kidney	RCC10RGB	7.5
Kidney	SNU1272	7.9
Kidney	SNU349	8.5
Kidney	TUHR10TKB	7.1
Kidney	TUHR14TKB	7.5
Kidney	TUHR4TKB	7.4
Kidney	VMRCRCW	7.8
Kidney	VMRCRCZ	7.6
Large intestine	C2BBE1	7.7
Large intestine	CCK81	7.4
Large intestine	CL11	6.8
Large intestine	CL14	7.1
Large intestine	CL34	7.4
Large intestine	CL40	7.6
Large intestine	COLO205	7.5
Large intestine	COLO320	6.9
Large intestine	COLO678	7
Large intestine	CW2	7.3
Large intestine	DLD1	6.8
Large intestine	GP2D	6.8
Large intestine	HCC56	7.7
Large intestine	HCT116	7.1
Large intestine	HCT15	7
Large intestine	HS675T	8
Large intestine	HS698T	7.7
Large intestine	HT115	7.5
Large intestine	HT29	8.3
Large intestine	HT55	7.7
Large intestine	KM12	7.6
Large intestine	LOVO	7.2
Large intestine	LS1034	7.1
Large intestine	LS123	7.9
Large intestine	LS180	7.3
Large intestine	LS411N	7.4
Large intestine	LS513	6.2
Large intestine	MDST8	8.2
Large intestine	NCIH508	7.5
Large intestine	NCIH716	7.8
Large intestine	NCIH747	7
Large intestine	OUMS23	7
Large intestine	RCM1	7.2
Large intestine	RKO	7.5
Large intestine	SKCO1	6.7
Large intestine	SNU1040	7.6
Large intestine	SNU1197	7.2
Large intestine	SNU175	7.1
Large intestine	SNU283	7.6
Large intestine	SNU407	7.1
Large intestine	SNU503	7.7
Large intestine	SNU61	7.2
Large intestine	SNU81	7.9
Large intestine	SNUC1	8.4
Large intestine	SNUC2A	7.4
Large intestine	SNUC4	7.4
Large intestine	SNUC5	7
Large intestine	SW1116	6.9
Large intestine	SW1417	7.4
Large intestine	SW1463	7.8
Large intestine	SW403	7.8
Large intestine	SW480	7.6
Large intestine	SW48	7.2
Large intestine	SW620	7.3
Large intestine	SW837	5.8
Large intestine	SW948	8.1
Large intestine	T84	7.7
Liver	ALEXANDERCELLS	6.9
Liver	C3A	7.5
Liver	HEP3B217	6.4
Liver	HEPG2	7.8
Liver	HLE	7.1
Liver	HLF	7.2
Liver	HUH1	7.9
Liver	HUH6	7
Liver	HUH7	7.1
Liver	JHH1	9
Liver	JHH2	8.3
Liver	JHH4	7.6
Liver	JHH5	7.9
Liver	JHH6	6.6
Liver	JHH7	7.4
Liver	LI7	8.8
Liver	PLCPRF5	7.7
Liver	SKHEP1	7.3
Liver	SNU182	8.8
Liver	SNU387	7.7
Liver	SNU398	8
Liver	SNU423	7.9
Liver	SNU449	8.2
Liver	SNU475	7.4
Liver	SNU761	7.9
Liver	SNU878	7.3
Liver	SNU886	7.9
Lung	A549	7.7
Lung	ABC1	7.7
Lung	BEN	9.1
Lung	CAL12T	7.4
Lung	CALU1	7.3
Lung	CALU3	7.9
Lung	CALU6	7.6
Lung	CHAGOK1	7.3
Lung	COLO668	7.4
Lung	COLO699	7.7
Lung	CORL105	7.8
Lung	CORL23	7
Lung	CORL24	7.4
Lung	CORL279	8
Lung	CORL311	7.3
Lung	CORL47	7.8
Lung	CORL51	7.8
Lung	CORL88	8.2
Lung	CORL95	7.7
Lung	CPCN	7.5
Lung	DMS114	8.4
Lung	DMS153	7.6
Lung	DMS273	7.9
Lung	DMS454	7.9
Lung	DMS53	8.3
Lung	DMS79	7.7
Lung	DV90	7.4
Lung	EBC1	7.5
Lung	EPLC272H	7.7
Lung	HARA	7.8
Lung	HCC1171	7.4
Lung	HCC1195	7.4
Lung	HCC15	7.8
Lung	HCC2279	8
Lung	HCC2935	7.2
Lung	HCC33	7.2
Lung	HCC366	6.6
Lung	HCC4006	7.1
Lung	HCC44	7.6
Lung	HCC78	7.5
Lung	HCC827	6.8
Lung	HCC95	6.7
Lung	HLC1	7.8
Lung	HLFA	8
Lung	HS229T	7.7
Lung	HS618T	8.2
Lung	IALM	7.6
Lung	KNS62	7.6
Lung	LC1F	7.2
Lung	LC1SQSF	6.8
Lung	LCLC103H	7
Lung	LCLC97TM1	6.7
Lung	LK2	6.6
Lung	LOUNH91	8.1
Lung	LU65	7.4
Lung	LU99	7.5
Lung	LUDLU1	7.4
Lung	LXF289	8.1
Lung	MORCPR	8.2
Lung	NCIH1048	7.5
Lung	NCIH1092	6.2
Lung	NCIH1105	7.2
Lung	NCIH1155	7.7
Lung	NCIH1184	7.3
Lung	NCIH1299	8.2
Lung	NCIH1339	7.5
Lung	NCIH1341	7.9
Lung	NCIH1355	7.7
Lung	NCIH1373	6.8
Lung	NCIH1385	8.7
Lung	NCIH1395	8.4
Lung	NCIH1435	7.1
Lung	NCIH1436	6.8
Lung	NCIH1437	7.3
Lung	NCIH146	8.1
Lung	NCIH1563	7.8
Lung	NCIH1568	7
Lung	NCIH1573	7.8
Lung	NCIH1581	6.9
Lung	NCIH1618	8
Lung	NCIH1623	8.5
Lung	NCIH1648	7.4
Lung	NCIH1650	7.7
Lung	NCIH1651	7.6
Lung	NCIH1666	8
Lung	NCIH1693	6.8
Lung	NCIH1694	7.9
Lung	NCIH1703	7.4
Lung	NCIH1734	8.1
Lung	NCIH1755	7.6
Lung	NCIH1781	7.5
Lung	NCIH1792	7.8
Lung	NCIH1793	8.5
Lung	NCIH1836	8
Lung	NCIH1838	7
Lung	NCIH1869	7.9
Lung	NCIH1876	7.2
Lung	NCIH1915	7.3
Lung	NCIH1930	7.2
Lung	NCIH1944	7.3
Lung	NCIH1963	7.9
Lung	NCIH196	7.7
Lung	NCIH1975	7.3
Lung	NCIH2009	7.1
Lung	NCIH2023	7.3
Lung	NCIH2029	8
Lung	NCIH2030	7.8
Lung	NCIH2066	7.6
Lung	NCIH2081	7.1
Lung	NCIH2085	8.2
Lung	NCIH2087	7.3
Lung	NCIH209	7.8
Lung	NCIH2106	9.4
Lung	NCIH2110	6
Lung	NCIH211	8.5
Lung	NCIH2122	7.8
Lung	NCIH2126	7.1
Lung	NCIH2141	7.3
Lung	NCIH2170	8.2
Lung	NCIH2171	7.7
Lung	NCIH2172	7.3
Lung	NCIH2196	8.3
Lung	NCIH2227	8.3
Lung	NCIH2228	7.7
Lung	NCIH226	8.1
Lung	NCIH2286	7.1
Lung	NCIH2291	7.1
Lung	NCIH2342	8
Lung	NCIH2347	7.1
Lung	NCIH23	7.7
Lung	NCIH2405	7
Lung	NCIH2444	8.2
Lung	NCIH292	8
Lung	NCIH322	7.5
Lung	NCIH3255	8
Lung	NCIH358	7
Lung	NCIH441	7.1
Lung	NCIH446	8.1
Lung	NCIH460	7.5
Lung	NCIH510	7.2
Lung	NCIH520	7.1
Lung	NCIH522	7.4
Lung	NCIH524	7.9
Lung	NCIH526	7.8
Lung	NCIH596	7.6
Lung	NCIH647	7.9
Lung	NCIH650	6.9
Lung	NCIH661	9.1
Lung	NCIH69	7.4
Lung	NCIH727	7
Lung	NCIH810	7.9
Lung	NCIH82	7.9
Lung	NCIH838	7.3
Lung	NCIH841	7.4
Lung	NCIH854	8.6
Lung	NCIH889	8.3
Lung	PC14	7.6
Lung	RERFLCAD1	6.8
Lung	RERFLCAD2	7.8
Lung	RERFLCAI	7.7
Lung	RERFLCKJ	7.8
Lung	RERFLCMS	7.3
Lung	RERFLCSQ1	8.4
Lung	SBC5	7.4
Lung	SCLC21H	8
Lung	SHP77	8.8
Lung	SKLU1	8.3
Lung	SKMES1	7.3
Lung	SQ1	8.1
Lung	SW1271	7.3
Lung	SW1573	7.2
Lung	SW900	8.2
Lung	VMRCLCD	7.9
Lung	VMRCLCP	7.4
Oesophagus	COLO680N	8.2
Oesophagus	ECGI10	6.6
Oesophagus	KYSE140	7.6
Oesophagus	KYSE150	7.7
Oesophagus	KYSE180	7.5
Oesophagus	KYSE270	7
Oesophagus	KYSE30	7.8
Oesophagus	KYSE410	7.8
Oesophagus	KYSE450	7.3
Oesophagus	KYSE510	6.9
Oesophagus	KYSE520	7.9
Oesophagus	KYSE70	7.7
Oesophagus	OE19	8.3
Oesophagus	OE33	7.2
Oesophagus	TE10	7.4
Oesophagus	TE11	7.4
Oesophagus	TE14	7.5
Oesophagus	TE15	6.9
Oesophagus	TE1	7.6
Oesophagus	TE4	6.6
Oesophagus	TE5	7.7
Oesophagus	TE6	7.3
Oesophagus	TE8	8.5
Oesophagus	TE9	7.6
Oesophagus	TT	7
Ovary	59M	8.3
Ovary	A2780	7.3
Ovary	CAOV3	8.4
Ovary	CAOV4	8.5
Ovary	COLO704	8.2
Ovary	COV318	7.5
Ovary	COV362	7.1
Ovary	COV434	7.6
Ovary	COV504	7.2
Ovary	COV644	8.4
Ovary	EFO21	7.9
Ovary	EFO27	8.3
Ovary	ES2	7.2
Ovary	FUOV1	10.5
Ovary	HEYA8	7.3
Ovary	HS571T	8.3
Ovary	IGROV1	8
Ovary	JHOC5	7.4
Ovary	JHOM1	7.3
Ovary	JHOM2B	7.2
Ovary	JHOS2	7.4
Ovary	JHOS4	8.5
Ovary	KURAMOCHI	8.3
Ovary	MCAS	6.9
Ovary	NIHOVCAR3	8.4
Ovary	OAW28	6.9
Ovary	OAW42	8.1
Ovary	OC314	8.3
Ovary	OC316	7.8
Ovary	ONCODG1	7.7
Ovary	OV56	7.7
Ovary	OV7	7.7
Ovary	OV90	8.1
Ovary	OVCAR4	8.2
Ovary	OVCAR8	6.4
Ovary	OVISE	8.4
Ovary	OVK18	8
Ovary	OVKATE	8.1
Ovary	OVMANA	7.7
Ovary	OVSAHO	8.7
Ovary	OVTOKO	7.8
Ovary	RMGI	8.2
Ovary	RMUGS	8.4
Ovary	SKOV3	7.6
Ovary	SNU119	7.4
Ovary	SNU840	7.5
Ovary	SNU8	7.5
Ovary	TOV112D	7.3
Ovary	TOV21G	7.5
Ovary	TYKNU	7.7
Pancreas	ASPC1	8.3
Pancreas	BXPC3	8.5
Pancreas	CAPAN1	7.4
Pancreas	CAPAN2	7.2
Pancreas	CFPAC1	7.8
Pancreas	DANG	7.6
Pancreas	HPAC	7.4
Pancreas	HPAFII	7.8
Pancreas	HS766T	7.7
Pancreas	HUPT3	7.4
Pancreas	HUPT4	7.7
Pancreas	KCIMOH1	7.4
Pancreas	KLM1	7.6
Pancreas	KP2	7.8
Pancreas	KP3	7.7
Pancreas	KP4	7.5
Pancreas	L33	7.8
Pancreas	MIAPACA2	7.8
Pancreas	PANC0203	7.2
Pancreas	PANC0213	7.7
Pancreas	PANC0327	7.5
Pancreas	PANC0403	7.2
Pancreas	PANC0504	7.6
Pancreas	PANC0813	7.3
Pancreas	PANC1005	7.4
Pancreas	PANC1	9
Pancreas	PATU8902	7
Pancreas	PATU8988S	8.2
Pancreas	PATU8988T	9.2
Pancreas	PK1	7.7
Pancreas	PK45H	7
Pancreas	PK59	8
Pancreas	PL45	7.1
Pancreas	PSN1	7.6
Pancreas	QGP1	9.9
Pancreas	SNU213	7.3
Pancreas	SNU324	7.4
Pancreas	SNU410	8.4
Pancreas	SU8686	9.3
Pancreas	SUIT2	6.5
Pancreas	SW1990	7.6
Pancreas	T3M4	6.9
Pancreas	TCCPAN2	8.4
Pancreas	YAPC	7.3
Pleura	ACCMESO1	6.9
Pleura	DM3	8.3
Pleura	ISTMES1	8.4
Pleura	ISTMES2	8.2
Pleura	JL1	7.5
Pleura	MPP89	8.6
Pleura	MSTO211H	6.7
Pleura	NCIH2052	8.2
Pleura	NCIH2452	6.8
Pleura	NCIH28	6.5
Prostate	22RV1	7.9
Prostate	DU145	7.2
Prostate	LNCAPCLONEFGC	8.2
Prostate	MDAPCA2B	8.5
Prostate	NCIH660	7
Prostate	PC3	7.7
Prostate	VCAP	7.4
Salivary gland	A253	7.4
Salivary gland	YD15	7.2
Skin	A101D	8.2
Skin	A2058	7.3
Skin	A375	7.6
Skin	C32	8
Skin	CHL1	9.6
Skin	CJM	6.9
Skin	COLO679	7.5
Skin	COLO741	8.2
Skin	COLO783	7.7
Skin	COLO792	7.2
Skin	COLO800	7.8
Skin	COLO818	7.4
Skin	COLO829	7.9
Skin	COLO849	7.7
Skin	G361	7.4
Skin	GRM	8
Skin	HMCB	8
Skin	HS294T	8.5
Skin	HS600T	8.1
Skin	HS688AT	8.2
Skin	HS695T	7.7
Skin	HS839T	8.2
Skin	HS852T	7.9
Skin	HS895T	8
Skin	HS934T	7.6
Skin	HS936T	8
Skin	HS939T	7.7
Skin	HS940T	7.6
Skin	HS944T	7.5
Skin	HT144	7.6
Skin	IGR1	7.3
Skin	IGR37	9.2
Skin	IGR39	8.1
Skin	IPC298	8.2
Skin	K029AX	8
Skin	LOXIMVI	7.2
Skin	MALME3M	8.3
Skin	MDAMB435S	7.1
Skin	MELHO	7.9
Skin	MELJUSO	7.9
Skin	MEWO	7.5
Skin	RPMI7951	7.6
Skin	RVH421	8
Skin	SH4	7.4
Skin	SKMEL1	8.2
Skin	SKMEL24	8.7
Skin	SKMEL28	7.9
Skin	SKMEL2	7.4
Skin	SKMEL30	7.5
Skin	SKMEL31	8.1
Skin	SKMEL3	8.7
Skin	SKMEL5	7.9
Skin	UACC257	8.1
Skin	UACC62	7.6
Skin	WM115	8
Skin	WM1799	7.3
Skin	WM2664	8.2
Skin	WM793	7
Skin	WM88	7.8
Skin	WM983B	6.8
Small intestine	HUTU80	7.8
Soft tissue	A204	7.4
Soft tissue	G401	8.1
Soft tissue	G402	8
Soft tissue	GCT	7.4
Soft tissue	HS729	7.3
Soft tissue	HT1080	7.2
Soft tissue	KYM1	7.4
Soft tissue	MESSA	8.1
Soft tissue	RD	8.7
Soft tissue	RH30	8.6
Soft tissue	RH41	9.1
Soft tissue	RKN	7.4
Soft tissue	S117	8.1
Soft tissue	SJRH30	8
Soft tissue	SKLMS1	7.8
Soft tissue	SKUT1	8
Soft tissue	TE125T	7.3
Soft tissue	TE159T	8
Soft tissue	TE441T	8.2
Soft tissue	TE617T	7.7
Stomach	2313287	6.8
Stomach	AGS	7.6
Stomach	AZ521	7.2
Stomach	ECC10	7.2
Stomach	ECC12	7.9
Stomach	FU97	8
Stomach	GCIY	8
Stomach	GSS	6.8
Stomach	GSU	7.3
Stomach	HGC27	7.7
Stomach	HS746T	7.3
Stomach	HUG1N	7.8
Stomach	IM95	7.5
Stomach	KATOIII	7.7
Stomach	KE39	7.2
Stomach	LMSU	7.2
Stomach	MKN1	7.8
Stomach	MKN45	7.5
Stomach	MKN74	7.7
Stomach	MKN7	7.7
Stomach	NCCSTCK140	9
Stomach	NCIN87	7.6
Stomach	NUGC2	8.6
Stomach	NUGC3	7.7
Stomach	NUGC4	7.5
Stomach	OCUM1	6.7
Stomach	RERFGC1B	8.4
Stomach	SH10TC	7.4
Stomach	SNU16	8.1
Stomach	SNU1	7.6
Stomach	SNU216	7.4
Stomach	SNU520	8.4
Stomach	SNU5	8.2
Stomach	SNU601	8.7
Stomach	SNU620	7.4
Stomach	SNU668	7.8
Stomach	SNU719	8.2
Stomach	TGBC11TKB	7.5
Thyroid	8305C	8.1
Thyroid	8505C	7.6
Thyroid	BCPAP	7.5
Thyroid	BHT101	6.3
Thyroid	CAL62	7.1
Thyroid	CGTHW1	7.5
Thyroid	FTC133	8.5
Thyroid	FTC238	7.2
Thyroid	ML1	7.5
Thyroid	SW579	7.9
Thyroid	TT2609C02	8
Thyroid	TT	7.6
Upper aerodigestive tract	BHY	7
Upper aerodigestive tract	BICR16	8
Upper aerodigestive tract	BICR18	7.3
Upper aerodigestive tract	BICR22	8
Upper aerodigestive tract	BICR31	6.5
Upper aerodigestive tract	BICR56	7.6
Upper aerodigestive tract	BICR6	8
Upper aerodigestive tract	CAL27	8.1
Upper aerodigestive tract	CAL33	7.9
Upper aerodigestive tract	DETROIT562	7.3
Upper aerodigestive tract	FADU	7.8
Upper aerodigestive tract	HS840T	8.1
Upper aerodigestive tract	HSC2	7.7
Upper aerodigestive tract	HSC3	7.7
Upper aerodigestive tract	HSC4	7.5
Upper aerodigestive tract	PECAPJ15	7.8
Upper aerodigestive tract	PECAPJ34CLONEC12	7.1
Upper aerodigestive tract	PECAPJ41CLONED2	7.6
Upper aerodigestive tract	PECAPJ49	7.9
Upper aerodigestive tract	SCC15	7.4
Upper aerodigestive tract	SCC25	7.6
Upper aerodigestive tract	SCC4	7.4
Upper aerodigestive tract	SCC9	7.5
Upper aerodigestive tract	SNU1076	7
Upper aerodigestive tract	SNU1214	7.4
Upper aerodigestive tract	SNU46	6.5
Upper aerodigestive tract	SNU899	7
Upper aerodigestive tract	YD10B	7.5
Upper aerodigestive tract	YD38	7.1
Upper aerodigestive tract	YD8	7.5
Urinary tract	5637	8
Urinary tract	639V	7.8
Urinary tract	647V	7.3
Urinary tract	BC3C	7.5
Urinary tract	BFTC905	6.7
Urinary tract	CAL29	7.7
Urinary tract	HS172T	8
Urinary tract	HT1197	6.8
Urinary tract	HT1376	7.1
Urinary tract	J82	8.2
Urinary tract	JMSU1	7
Urinary tract	KMBC2	7.3
Urinary tract	KU1919	7.5
Urinary tract	RT11284	7.8
Urinary tract	RT112	8.2
Urinary tract	RT4	8.1
Urinary tract	SCABER	7.9
Urinary tract	SW1710	7.6
Urinary tract	SW780	8
Urinary tract	T24	8
Urinary tract	TCCSUP	7.9
Urinary tract	UMUC1	8.4
Urinary tract	UMUC3	7.2
Urinary tract	VMCUB1	7

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	22.6
Adrenal gland	18.6
Appendix	15.4
Bone marrow	10.4
Breast	14.3
Cerebral cortex	84.2
Cervix, uterine	20.6
Colon	10.7
Duodenum	12.7
Endometrium	20.5
Epididymis	11
Esophagus	26
Fallopian tube	27.2
Gallbladder	22.3
Heart muscle	19.3
Kidney	12
Liver	8.5
Lung	21.9
Lymph node	14.8
Ovary	28.1
Pancreas	2.6
Parathyroid gland	19.8
Placenta	14.1
Prostate	19.1
Rectum	10.5
Salivary gland	9.3
Seminal vesicle	19.3
Skeletal muscle	63.3
Skin	22.5
Small intestine	14.1
Smooth muscle	24.9
Spleen	19.5
Stomach	11.3
Testis	19.6
Thyroid gland	22
Tonsil	11.4
Urinary bladder	17.4

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
27586085	Overexpression	Acute Myeloid Leukemia	Importantly, SIRT2 is overexpressed in clinical AML samples, while K403 acetylation is downregulated and G6PD catalytic activity is increased comparing to that of normal control.
27291931	Overexpression	Acute Myeloid Leukemia	High SIRT2 expression was associated with significantly shorter overall survival (OS; P=0.0005) and event-free survival (EFS; P=0.0002) than low SIRT2 expressio in a cohort of 167 patients with AML.
27171429	Overexpression	Melanoma	SIRT2 expression was higher in melanomas than in normal melanocytes of both tumor and donor eyes (p < 0.0001).
25915617	Overexpression	Non-Small Cell Lung Cancer	High SIRT1 and SIRT2 protein levels were found in NSCLC cell lines compared with non-tumor lung epithelial cells.
25794641	Overexpression	Cervical Carcinoma	A progressive increase in the expression of both SIRT2 and SIRT7 was noted during cancer progression in the following order: normal
25719312	Underexpression	Non-Small Cell Lung Cancer	In the present study, we identified that the SIRT2 as an anti-oncogenic protein in NSCLC was down-regulated.
24183459	Aberrant Expression	Breast Carcinoma	Our data suggest that SIRT2 is the sirtuin predominantly involved in breast tumourigenesis and prognosis.
23915912	Underexpression	Non-Small Cell Lung Cancer	In this study, we analyzed the expression pattern of SIRT2 in NSCLC tissues from clinical patients and in cell lines, and found that SIRT2 was significantly down-regulated at both the mRNA and protein levels in tumor than non-tumor tissues or cells, which were corroborated by the NSCLC tissue microarray results.
23348706	Overexpression	Hepatocellular Carcinoma	SIRT2 is up-regulated in HCC cell lines and in a subset of human HCC tissues (23/45). Up-regulations of SIRT2 in primary HCC tumors were significantly correlated with the presence of microscopic vascular invasion (P = 0.001), a more advanced tumor stage (P = 0.004), and shorter overall survival (P = 0.0499).
22166219	Underexpression	Glioma	Our studies, by conducting such assays as flow cytometry-based Annexin V assay and caspase-3 immunostaining, have indicated that decreased SIRT2 activity leads to apoptosis of C6 glioma cells by caspase-3-dependent pathway.
12963026	Underexpression	Glioma	We then focused on the cytoskeleton-related protein, SIRT2 (sirtuin homologue 2) tubulin deacetylase, which was down-regulated in gliomas.
23475622	Underexpression	Head and Neck Squamous Cell Carcinoma	Our results demonstrated that the expression levels of SIRT1, SIRT2, SIRT3, SIRT5, SIRT6, and SIRT7 were significantly downregulated in cancerous tissues compared with noncancerous tissues (all p<0.01).
28259910	Underexpression	Ovarian Carcinoma	It was observed that SIRT2 expression in SOC was significantly downregulated when compared with ovarian surface epithelium via western blot and immunohistochemistry.
28166441	Overexpression	Melanoma	Employing a tissue microarray containing benign nevi, primary melanomas, and lymph node metastases, we have found that the tissue from lymph node metastases appears to have a significant upregulation of SIRT2 relative to primary tumors across the nuclear, cytoplasmic, and whole cell data.
28088387	Underexpression	Colorectal Carcinoma	The results demonstrated that SIRT2 is downregulated in CRC biopsy samples (n=31) compared with the adjacent non-cancerous tissues (ANCT, n=26).
28073696	Overexpression	Non-Small Cell Lung Carcinoma	We also found that the levels of SPOP significantly decreased, while the levels of SIRT2 significantly increased in non-small cell lung cancer (NSCLC) cell lines, compared to normal bronchial epithelial cell line and NSCLC specimens, compared to the paired non-tumor lung tissue.
27783945	Copy Number Gain; Overexpression	Breast Carcinoma	Interestingly, SIRT2 is frequently amplified and highly expressed in BLBC.

Summary
Symbol	SIRT2
Name	sirtuin 2
Aliases	SIR2L; sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 2; sirtuin (silent matin ......
Location	19q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.633	1.16e-46	11.9	46.8	41.3	Gain
BRCA	Breast invasive carcinoma	1075	0.643	1.56e-126	15.7	60.2	24.1	Neutral
CESC	Cervical and endocervical cancers	292	0.662	3.15e-38	9.2	59.6	31.2	Neutral
COAD	Colon adenocarcinoma	449	0.448	1.37e-23	7.8	71.9	20.3	Neutral
ESCA	Esophageal carcinoma	183	0.361	5.07e-07	26.8	48.1	25.1	Neutral
GBM	Glioblastoma multiforme	147	0.193	0.0191	9.5	60.5	29.9	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.495	3.52e-33	17.1	67.3	15.6	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.223	2.42e-07	1	88.2	10.9	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.222	0.00015	5.9	92.4	1.7	Neutral
LAML	Acute Myeloid Leukemia	166	0.156	0.0449	1.8	95.2	3	Neutral
LGG	Brain Lower Grade Glioma	513	0.263	1.42e-09	43.5	50.5	6	Loss
LIHC	Liver hepatocellular carcinoma	364	0.363	9.3e-13	9.6	68.7	21.7	Neutral
LUAD	Lung adenocarcinoma	512	0.507	9.3e-35	25	49.8	25.2	Neutral
LUSC	Lung squamous cell carcinoma	498	0.644	1.39e-59	17.1	37.8	45.2	Gain
OV	Ovarian serous cystadenocarcinoma	300	0.716	1.6e-48	24.3	32.7	43	Gain
PAAD	Pancreatic adenocarcinoma	177	0.642	6.02e-22	4	70.6	25.4	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.358	2.92e-06	4.3	88.3	7.4	Neutral
PRAD	Prostate adenocarcinoma	491	0.266	2.2e-09	6.1	91.9	2	Neutral
READ	Rectum adenocarcinoma	164	0.444	2.64e-09	9.1	67.1	23.8	Neutral
SARC	Sarcoma	255	0.65	4.89e-32	23.5	48.6	27.8	Neutral
SKCM	Skin Cutaneous Melanoma	367	0.288	2e-08	19.3	64.6	16.1	Neutral
STAD	Stomach adenocarcinoma	413	0.506	2.75e-28	16	61.5	22.5	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.212	0.00922	36.7	44.7	18.7	Loss
THCA	Thyroid carcinoma	497	0.208	2.92e-06	0.2	97.8	2	Neutral
THYM	Thymoma	119	0.469	7.63e-08	2.5	95	2.5	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.459	2.4e-29	8.4	76.7	14.9	Neutral

Summary
Symbol	SIRT2
Name	sirtuin 2
Aliases	SIR2L; sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 2; sirtuin (silent matin ......
Location	19q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	0.154	0.00152	17	408	-0.01	0.00556	NS/NA
BRCA	Breast invasive carcinoma	-0.003	0.927	83	785	-0.007	0.0501	NS/NA
CESC	Cervical and endocervical cancers	0.196	0.000552	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.014	0.806	19	297	-0.006	0.243	NS/NA
ESCA	Esophageal carcinoma	-0.031	0.665	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	0.196	0.117	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	0.006	0.885	20	522	-0.006	0.1	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.122	0.0236	24	319	-0.002	0.412	NS/NA
KIRP	Kidney renal papillary cell carcinoma	0.066	0.254	23	275	-0.01	0.019	NS/NA
LAML	Acute Myeloid Leukemia	-0.068	0.379	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	0.077	0.0777	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.095	0.0528	41	373	-0.008	0.000381	NS/NA
LUAD	Lung adenocarcinoma	-0.069	0.132	21	456	-0.016	0.00765	NS/NA
LUSC	Lung squamous cell carcinoma	0.015	0.777	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.067	0.88	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	0.038	0.606	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	0.079	0.284	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.161	0.000198	35	498	-0.022	1.5e-10	NS/NA
READ	Rectum adenocarcinoma	-0.035	0.73	2	99	NA	NA	NS/NA
SARC	Sarcoma	0.077	0.215	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.07	0.126	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	0.321	2.76e-10	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.138	0.0856	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.088	0.0375	50	509	-0.009	0.128	NS/NA
THYM	Thymoma	0.029	0.75	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	0.164	0.00038	34	431	-0.006	0.0141	NS/NA

Summary
Symbol	SIRT2
Name	sirtuin 2
Aliases	SIR2L; sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 2; sirtuin (silent matin ......
Location	19q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

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Tissue	Level	Level Name
Adrenal gland	2	Medium
Appendix	0	Not detected
Bone marrow	0	Not detected
Breast	2	Medium
Bronchus	0	Not detected
Caudate	0	Not detected
Cerebellum	0	Not detected
Cerebral cortex	2	Medium
Cervix, uterine	0	Not detected
Colon	0	Not detected
Duodenum	2	Medium
Endometrium	0	Not detected
Epididymis	0	Not detected
Esophagus	0	Not detected
Fallopian tube	0	Not detected
Gallbladder	0	Not detected
Heart muscle	1	Low
Hippocampus	0	Not detected
Kidney	1	Low
Liver	0	Not detected
Lung	2	Medium
Lymph node	0	Not detected
Nasopharynx	0	Not detected
Oral mucosa	0	Not detected
Ovary	0	Not detected
Pancreas	0	Not detected
Parathyroid gland	0	Not detected
Placenta	0	Not detected
Prostate	0	Not detected
Rectum	2	Medium
Salivary gland	0	Not detected
Seminal vesicle	0	Not detected
Skeletal muscle	2	Medium
Skin	0	Not detected
Small intestine	2	Medium
Smooth muscle	3	High
Soft tissue	0	Not detected
Spleen	0	Not detected
Stomach	0	Not detected
Testis	2	Medium
Thyroid gland	0	Not detected
Tonsil	0	Not detected
Urinary bladder	0	Not detected
Vagina	0	Not detected

Summary
Symbol	SIRT2
Name	sirtuin 2
Aliases	SIR2L; sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 2; sirtuin (silent matin ......
Location	19q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

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Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.0114	Significant	24476821
BRCA	Breast invasive carcinoma	521	7.58e-07	Significant	23000897
COAD	Colon adenocarcinoma	149	0.00016	Significant	22810696
GBM	Glioblastoma multiforme	157	5.19e-09	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	0.0405	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.000157	Significant	26536169
LGG	Brain Lower Grade Glioma	513	9.31e-22	Significant	26824661
LUAD	Lung adenocarcinoma	230	0.000361	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	0.00522	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.201	NS	21720365
PRAD	Prostate adenocarcinoma	333	0.00228	Significant	26544944
READ	Rectum adenocarcinoma	67	0.0729	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.00225	Significant	26091043
STAD	Stomach adenocarcinoma	277	0.389	NS	25079317
THCA	Thyroid carcinoma	391	3.49e-22	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.000698	Significant	23636398

> Overall survival

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Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	1.288	0.234	NS
BRCA	Breast invasive carcinoma	1079	0.809	0.353	NS
CESC	Cervical and endocervical cancers	291	0.804	0.515	NS
COAD	Colon adenocarcinoma	439	0.944	0.848	NS
ESCA	Esophageal carcinoma	184	0.665	0.219	NS
GBM	Glioblastoma multiforme	158	0.546	0.0186	Longer
HNSC	Head and Neck squamous cell carcinoma	518	0.781	0.209	NS
KIRC	Kidney renal clear cell carcinoma	531	0.912	0.656	NS
KIRP	Kidney renal papillary cell carcinoma	287	1.122	0.779	NS
LAML	Acute Myeloid Leukemia	149	2.248	0.00508	Shorter
LGG	Brain Lower Grade Glioma	511	0.48	0.00231	Longer
LIHC	Liver hepatocellular carcinoma	365	1.063	0.8	NS
LUAD	Lung adenocarcinoma	502	0.703	0.0938	NS
LUSC	Lung squamous cell carcinoma	494	0.679	0.0549	NS
OV	Ovarian serous cystadenocarcinoma	303	1.045	0.839	NS
PAAD	Pancreatic adenocarcinoma	177	0.631	0.107	NS
PCPG	Pheochromocytoma and Paraganglioma	179	0.537	0.606	NS
PRAD	Prostate adenocarcinoma	497	2.833	0.341	NS
READ	Rectum adenocarcinoma	159	1.538	0.464	NS
SARC	Sarcoma	259	0.966	0.9	NS
SKCM	Skin Cutaneous Melanoma	459	1.86	0.00082	Shorter
STAD	Stomach adenocarcinoma	388	1.137	0.566	NS
TGCT	Testicular Germ Cell Tumors	134	663407841.738	0.292	NS
THCA	Thyroid carcinoma	500	0.394	0.239	NS
THYM	Thymoma	119	4.263	0.159	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	1.879	0.0144	Shorter

> Stage

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Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	0.06	0.227	NS
BRCA	Breast invasive carcinoma	1071	0.046	0.13	NS
CESC	Cervical and endocervical cancers	167	0.155	0.0459	Higher
COAD	Colon adenocarcinoma	445	0.047	0.327	NS
ESCA	Esophageal carcinoma	162	-0.184	0.0191	Lower
HNSC	Head and Neck squamous cell carcinoma	448	0.021	0.66	NS
KIRC	Kidney renal clear cell carcinoma	531	0.042	0.332	NS
KIRP	Kidney renal papillary cell carcinoma	260	0.136	0.0287	Higher
LIHC	Liver hepatocellular carcinoma	347	0.024	0.654	NS
LUAD	Lung adenocarcinoma	507	-0.093	0.0359	Lower
LUSC	Lung squamous cell carcinoma	497	0.061	0.177	NS
OV	Ovarian serous cystadenocarcinoma	302	0.071	0.218	NS
PAAD	Pancreatic adenocarcinoma	176	0.061	0.419	NS
READ	Rectum adenocarcinoma	156	0.048	0.556	NS
SKCM	Skin Cutaneous Melanoma	410	0.048	0.332	NS
STAD	Stomach adenocarcinoma	392	-0.091	0.0733	NS
TGCT	Testicular Germ Cell Tumors	81	-0.111	0.324	NS
THCA	Thyroid carcinoma	499	0.05	0.264	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.014	0.758	NS

> Grade

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Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	-0.079	0.196	NS
HNSC	Head and Neck squamous cell carcinoma	498	-0.166	2e-04	Lower
KIRC	Kidney renal clear cell carcinoma	525	0.021	0.628	NS
LGG	Brain Lower Grade Glioma	514	-0.101	0.0216	Lower
LIHC	Liver hepatocellular carcinoma	366	-0.065	0.211	NS
OV	Ovarian serous cystadenocarcinoma	296	-0.043	0.461	NS
PAAD	Pancreatic adenocarcinoma	176	-0.094	0.213	NS
STAD	Stomach adenocarcinoma	406	0.043	0.386	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.139	0.00125	Higher

Summary
Symbol	SIRT2
Name	sirtuin 2
Aliases	SIR2L; sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 2; sirtuin (silent matin ......
Location	19q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	SIRT2
Name	sirtuin 2
Aliases	SIR2L; sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 2; sirtuin (silent matin ......
Location	19q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for SIRT2.

Summary
Symbol	SIRT2
Name	sirtuin 2
Aliases	SIR2L; sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 2; sirtuin (silent matin ......
Location	19q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

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PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
25719312	Non-Small Cell Lung Cancer	downstream	JMJD2A	Negative regulation	JMJD2A as a target of SIRT2 was negatively correlated with SIRT2 level in NSCLC.
28088387	Colorectal Carcinoma	downstream	phospho-ERK	Negative regulation	The antitumor effects of shikonin on CRC seem to be mediated by SIRT2 upregulation via phospho-ERK inhibition.
28073696	Non-Small Cell Lung Carcinoma	upstream	SPOP	Negative regulation	Notably, mutations in NSCLC inhibit the abilities of SPOP to degrade SIRT2 and suppress NSCLC cell growth.
27783945	Breast Carcinoma	downstream	Slug	Positive regulation	SIRT2 inhibition rapidly destabilizes Slug, whereas SIRT2 overexpression extends Slug stability.