CR2Cancer

Summary
Symbol	SMARCA1
Name	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
Aliases	NURF140; SWI; hSNF2L; SNF2L1; SNF2L; SNF2LT; ATP-dependent helicase SMARCA1; SNF2-like 1; nucleosome-remodel ......
Location	Xq25-q26.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

[ TOP ]

Domain

PF13892 DNA-binding domain
PF09110 HAND
PF00271 Helicase conserved C-terminal domain
PF09111 SLIDE
PF00176 SNF2 family N-terminal domain

Function

Energy-transducing component of NURF (nucleosome-remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes. Both complexes facilitate the perturbation of chromatin structure in an ATP-dependent manner. Potentiates neurite outgrowth. May be involved in brain development by regulating En-1 and En-2 expression. May be involved in the development of luteal cells.

Classification

Class	Modification	Substrate	Product	PubMed
Chromatin remodelling, Histone modification erase	#, Histone acetylation	#	#	15310751

> Gene Ontology [ TOP ]
Biological Process	GO:0000733 DNA strand renaturation GO:0006338 chromatin remodeling GO:0043044 ATP-dependent chromatin remodeling
Molecular Function	GO:0003682 chromatin binding GO:0004386 helicase activity GO:0008094 DNA-dependent ATPase activity GO:0016887 ATPase activity GO:0031491 nucleosome binding GO:0036310 annealing helicase activity GO:0042623 ATPase activity, coupled GO:0070615 nucleosome-dependent ATPase activity GO:0097617 annealing activity
Cellular Component	GO:0016589 NURF complex GO:0031010 ISWI-type complex GO:0070603 SWI/SNF superfamily-type complex GO:0090537 CERF complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	-

Summary
Symbol	SMARCA1
Name	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
Aliases	NURF140; SWI; hSNF2L; SNF2L1; SNF2L; SNF2LT; ATP-dependent helicase SMARCA1; SNF2-like 1; nucleosome-remodel ......
Location	Xq25-q26.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM4728264	c.1702T>A	p.F568I	Substitution - Missense	Large_intestine
COSM3390403	c.2565-4C>T	p.?	Unknown	Pancreas
COSM3396412	c.1505-3T>G	p.?	Unknown	Prostate
COSM5367013	c.399T>C	p.D133D	Substitution - coding silent	Large_intestine
COSM4392338	c.3030+1G>A	p.?	Unknown	Prostate
COSM4436949	c.3055C>G	p.L1019V	Substitution - Missense	Oesophagus
COSM1331261	c.1860C>G	p.F620L	Substitution - Missense	Ovary
COSM1114785	c.2147G>T	p.R716I	Substitution - Missense	Endometrium
COSM5177205	c.1127delA	p.N376fs*16	Deletion - Frameshift	Large_intestine
COSM2725347	c.3043C>T	p.R1015C	Substitution - Missense	Cervix
COSM118080	c.2412T>C	p.I804I	Substitution - coding silent	Ovary
COSM1114787	c.1852C>T	p.R618C	Substitution - Missense	Endometrium
COSM308155	c.1594C>A	p.L532M	Substitution - Missense	Biliary_tract
COSM4728262	c.3105_3106delAG	p.R1035fs*9	Deletion - Frameshift	Large_intestine
COSM258058	c.443G>A	p.R148H	Substitution - Missense	Large_intestine
COSM1114781	c.2557C>G	p.L853V	Substitution - Missense	Endometrium
COSM1756379	c.837G>T	p.M279I	Substitution - Missense	Urinary_tract
COSM5435199	c.2246C>T	p.P749L	Substitution - Missense	Oesophagus
COSM4106534	c.2743A>C	p.I915L	Substitution - Missense	Stomach
COSM1132410	c.2829C>A	p.Y943*	Substitution - Nonsense	Prostate
COSM456720	c.1384C>G	p.H462D	Substitution - Missense	Skin
COSM3973224	c.1300G>C	p.D434H	Substitution - Missense	Central_nervous_system
COSM1664265	c.2185T>G	p.F729V	Substitution - Missense	Kidney
COSM755440	c.1530G>T	p.Q510H	Substitution - Missense	Lung
COSM1114824	c.149C>T	p.T50M	Substitution - Missense	Endometrium
COSM3713854	c.824G>T	p.R275L	Substitution - Missense	Upper_aerodigestive_tract
COSM4386755	c.548T>G	p.L183R	Substitution - Missense	Lung
COSM3557677	c.2587C>T	p.R863*	Substitution - Nonsense	Skin
COSM456720	c.1384C>G	p.H462D	Substitution - Missense	Breast
COSM5750531	c.929T>C	p.I310T	Substitution - Missense	Stomach
COSM1114801	c.1299A>C	p.K433N	Substitution - Missense	Endometrium
COSM3396412	c.1505-3T>G	p.?	Unknown	Prostate
COSM5959316	c.139A>G	p.T47A	Substitution - Missense	Thyroid
COSM5005415	c.1190G>A	p.R397H	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM755442	c.2818-2A>C	p.?	Unknown	Lung
COSM1114817	c.468G>A	p.E156E	Substitution - coding silent	Endometrium
COSM1490467	c.1455T>A	p.S485R	Substitution - Missense	Breast
COSM2725355	c.2618A>T	p.E873V	Substitution - Missense	Large_intestine
COSM251142	c.478G>A	p.E160K	Substitution - Missense	Liver
COSM3723639	c.2769A>C	p.E923D	Substitution - Missense	Upper_aerodigestive_tract
COSM369386	c.2226G>T	p.M742I	Substitution - Missense	Lung
COSM5552876	c.459A>T	p.E153D	Substitution - Missense	Prostate
COSM1114797	c.1497_1498insA	p.E500fs*29	Insertion - Frameshift	Endometrium
COSM1556051	c.1029G>A	p.L343L	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM5577753	c.538G>A	p.G180R	Substitution - Missense	Skin
COSM3725137	c.912C>G	p.H304Q	Substitution - Missense	Lung
COSM3557681	c.1816-1G>A	p.?	Unknown	Skin
COSM1637190	c.530-1G>A	p.?	Unknown	Bone
COSM3424447	c.1531A>G	p.M511V	Substitution - Missense	Large_intestine
COSM1114824	c.149C>T	p.T50M	Substitution - Missense	Large_intestine
COSM4156575	c.174G>A	p.E58E	Substitution - coding silent	Thyroid
COSM1114826	c.78C>T	p.D26D	Substitution - coding silent	Endometrium
COSM1114803	c.1242G>T	p.K414N	Substitution - Missense	Endometrium
COSM82374	c.585C>A	p.I195I	Substitution - coding silent	Ovary
COSM755437	c.446C>T	p.T149I	Substitution - Missense	Lung
COSM253100	c.2128delA	p.M710fs*6	Deletion - Frameshift	Large_intestine
COSM4393506	c.2978G>C	p.R993P	Substitution - Missense	Prostate
COSM5749641	c.1109C>T	p.S370F	Substitution - Missense	Genital_tract
COSM4792252	c.319C>G	p.H107D	Substitution - Missense	Liver
COSM1756379	c.837G>T	p.M279I	Substitution - Missense	Urinary_tract
COSM3800393	c.2752C>G	p.Q918E	Substitution - Missense	Urinary_tract
COSM755436	c.417T>G	p.I139M	Substitution - Missense	Lung
COSM5000569	c.2314C>G	p.P772A	Substitution - Missense	Pancreas
COSM253100	c.2128delA	p.M710fs*6	Deletion - Frameshift	Ovary
COSM1114791	c.1639G>T	p.E547*	Substitution - Nonsense	Endometrium
COSM1114773	c.2685C>A	p.V895V	Substitution - coding silent	Endometrium
COSM79057	c.757C>T	p.R253*	Substitution - Nonsense	Ovary
COSM487922	c.272G>A	p.R91Q	Substitution - Missense	Kidney
COSM1643943	c.2896G>A	p.E966K	Substitution - Missense	Stomach
COSM1665759	c.1462delA	p.M488fs*2	Deletion - Frameshift	Kidney
COSM255810	c.1714C>T	p.L572L	Substitution - coding silent	Central_nervous_system
COSM1114795	c.1498G>T	p.E500*	Substitution - Nonsense	Endometrium
COSM3372054	c.534G>C	p.V178V	Substitution - coding silent	Thyroid
COSM5064355	c.917G>A	p.R306Q	Substitution - Missense	Stomach
COSM1569706	c.2351C>G	p.P784R	Substitution - Missense	Large_intestine
COSM1465512	c.794G>T	p.G265V	Substitution - Missense	Large_intestine
COSM1114763	c.3044G>A	p.R1015H	Substitution - Missense	Endometrium
COSM1625488	c.2954A>G	p.Y985C	Substitution - Missense	Liver
COSM1114805	c.1109C>A	p.S370Y	Substitution - Missense	Endometrium
COSM5450622	c.1551T>G	p.I517M	Substitution - Missense	Large_intestine
COSM3843511	c.1319C>T	p.S440F	Substitution - Missense	Breast
COSM5467813	c.2127A>C	p.K709N	Substitution - Missense	Large_intestine
COSM1114799	c.1458T>A	p.G486G	Substitution - coding silent	Endometrium
COSM5812439	c.546A>T	p.P182P	Substitution - coding silent	Liver
COSM3800394	c.2359C>T	p.Q787*	Substitution - Nonsense	Urinary_tract
COSM1114803	c.1242G>T	p.K414N	Substitution - Missense	Large_intestine
COSM1490468	c.962C>A	p.S321Y	Substitution - Missense	Breast
COSM5016708	c.2236_2242delATTGAAC	p.I746fs*64	Deletion - Frameshift	Kidney
COSM3770673	c.1254delG	p.L419fs*1	Deletion - Frameshift	Soft_tissue
COSM1490471	c.126G>A	p.A42A	Substitution - coding silent	Thyroid
COSM1465508	c.2257C>T	p.R753C	Substitution - Missense	Large_intestine
COSM1114819	c.460G>T	p.D154Y	Substitution - Missense	Endometrium
COSM392049	c.175-1delG	p.?	Unknown	Lung
COSM3713854	c.824G>T	p.R275L	Substitution - Missense	Upper_aerodigestive_tract
COSM3964684	c.2851C>A	p.R951S	Substitution - Missense	Lung
COSM4728263	c.2958A>G	p.E986E	Substitution - coding silent	Large_intestine
COSM1625488	c.2954A>G	p.Y985C	Substitution - Missense	Liver
COSM4938389	c.889A>T	p.K297*	Substitution - Nonsense	Liver
COSM367812	c.619G>T	p.A207S	Substitution - Missense	Lung
COSM362721	c.2506G>A	p.D836N	Substitution - Missense	Lung
COSM755435	c.103C>G	p.Q35E	Substitution - Missense	Lung
COSM5347923	c.1986delA	p.E663fs*6	Deletion - Frameshift	Liver
COSM4106536	c.2116C>T	p.R706C	Substitution - Missense	Stomach
COSM487921	c.1084T>C	p.F362L	Substitution - Missense	Kidney
COSM3557680	c.1819C>T	p.R607*	Substitution - Nonsense	Skin
COSM5775127	c.103C>T	p.Q35*	Substitution - Nonsense	Breast
COSM4728265	c.1611G>A	p.P537P	Substitution - coding silent	Large_intestine
COSM4535459	c.2194G>A	p.E732K	Substitution - Missense	Skin
COSM5655920	c.1922G>C	p.R641T	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM2725387	c.858C>T	p.C286C	Substitution - coding silent	Biliary_tract
COSM1490471	c.126G>A	p.A42A	Substitution - coding silent	Breast
COSM3424448	c.705C>A	p.H235Q	Substitution - Missense	Large_intestine
COSM3557679	c.2424G>A	p.R808R	Substitution - coding silent	Skin
COSM5647979	c.2251C>T	p.R751*	Substitution - Nonsense	Oesophagus
COSM1114765	c.2996G>T	p.R999I	Substitution - Missense	Endometrium
COSM5433242	c.1384C>T	p.H462Y	Substitution - Missense	Oesophagus
COSM1465521	c.169_171delAAG	p.K57delK	Deletion - In frame	Large_intestine
COSM5005567	c.811-2A>G	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM1114785	c.2147G>T	p.R716I	Substitution - Missense	Endometrium
COSM78542	c.1574G>A	p.R525H	Substitution - Missense	Ovary
COSM144478	c.1004G>A	p.R335H	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4792252	c.319C>G	p.H107D	Substitution - Missense	Liver
COSM203615	c.386G>A	p.R129Q	Substitution - Missense	Endometrium
COSM5411960	c.2863G>A	p.G955R	Substitution - Missense	Skin
COSM2152834	c.123C>T	p.A41A	Substitution - coding silent	Central_nervous_system
COSM1465508	c.2257C>T	p.R753C	Substitution - Missense	Stomach
COSM1569707	c.2761C>T	p.R921C	Substitution - Missense	Large_intestine
COSM3405946	c.2172A>C	p.Q724H	Substitution - Missense	Central_nervous_system
COSM5002573	c.1093G>T	p.A365S	Substitution - Missense	Pancreas
COSM5665456	c.421G>C	p.A141P	Substitution - Missense	Soft_tissue
COSM2152834	c.123C>T	p.A41A	Substitution - coding silent	Central_nervous_system
COSM4728267	c.393G>T	p.K131N	Substitution - Missense	Large_intestine
COSM1114783	c.2475T>C	p.A825A	Substitution - coding silent	Endometrium
COSM1266206	c.2213A>T	p.Q738L	Substitution - Missense	Oesophagus
COSM5438788	c.844G>T	p.E282*	Substitution - Nonsense	Oesophagus
COSM1715512	c.1675G>A	p.A559T	Substitution - Missense	Skin
COSM1465507	c.2716T>C	p.C906R	Substitution - Missense	Large_intestine
COSM1114767	c.2978G>A	p.R993Q	Substitution - Missense	Endometrium
COSM1114815	c.524C>A	p.P175H	Substitution - Missense	Endometrium
COSM5029010	c.962C>G	p.S321C	Substitution - Missense	Breast
COSM1114789	c.1794A>T	p.P598P	Substitution - coding silent	Endometrium
COSM1114787	c.1852C>T	p.R618C	Substitution - Missense	Large_intestine
COSM298514	c.2713C>T	p.R905C	Substitution - Missense	Large_intestine
COSM1114809	c.886G>T	p.E296*	Substitution - Nonsense	Endometrium
COSM1114828	c.2T>C	p.M1T	Substitution - Missense	Endometrium
COSM3708428	c.530-4C>T	p.?	Unknown	Liver
COSM4487072	c.3137C>T	p.P1046L	Substitution - Missense	Skin
COSM277375	c.2535G>A	p.E845E	Substitution - coding silent	Large_intestine
COSM1114807	c.1050G>A	p.L350L	Substitution - coding silent	Endometrium
COSM5366854	c.2825G>T	p.R942I	Substitution - Missense	Large_intestine
COSM5435200	c.793G>A	p.G265R	Substitution - Missense	Oesophagus
COSM3843512	c.1149C>T	p.L383L	Substitution - coding silent	Breast
COSM4568086	c.2781_2782AC>TT	p.Q927_R928>H*	Complex - compound substitution	Skin
COSM1465521	c.169_171delAAG	p.K57delK	Deletion - In frame	Oesophagus
COSM5588982	c.1904G>A	p.R635K	Substitution - Missense	Skin
COSM2725355	c.2618A>T	p.E873V	Substitution - Missense	Large_intestine
COSM5064356	c.859G>A	p.V287I	Substitution - Missense	Stomach
COSM1114813	c.668G>A	p.G223D	Substitution - Missense	Stomach
COSM1331262	c.2580G>C	p.W860C	Substitution - Missense	Ovary
COSM21740	c.1815+1G>A	p.?	Unknown	Skin
COSM1114793	c.1497_1500delAGAA	p.K499fs*12	Deletion - Frameshift	Endometrium
COSM5903299	c.823C>T	p.R275C	Substitution - Missense	Skin
COSM1490469	c.433C>T	p.R145C	Substitution - Missense	Breast
COSM4449547	c.262-1G>A	p.?	Unknown	Skin
COSM4635777	c.2921T>C	p.L974S	Substitution - Missense	Large_intestine
COSM2725393	c.172G>A	p.E58K	Substitution - Missense	Thyroid
COSM456719	c.2359delC	p.Q787fs*25	Deletion - Frameshift	Breast
COSM4807444	c.1793C>T	p.P598L	Substitution - Missense	Pancreas
COSM1465508	c.2257C>T	p.R753C	Substitution - Missense	Large_intestine
COSM1465509	c.983G>A	p.R328H	Substitution - Missense	Large_intestine
COSM3557683	c.514G>T	p.E172*	Substitution - Nonsense	Skin
COSM1465521	c.169_171delAAG	p.K57delK	Deletion - In frame	Large_intestine
COSM4728266	c.1134T>C	p.L378L	Substitution - coding silent	Large_intestine
COSM2725382	c.1370G>A	p.R457Q	Substitution - Missense	Large_intestine
COSM405234	c.3030_3030+1insTG	p.E1011fs*10	Unknown	Lung
COSM3939781	c.271C>T	p.R91*	Substitution - Nonsense	Oesophagus
COSM5910094	c.2722G>A	p.E908K	Substitution - Missense	Skin
COSM1114822	c.177A>C	p.K59N	Substitution - Missense	Large_intestine
COSM5007579	c.3109G>T	p.E1037*	Substitution - Nonsense	Large_intestine
COSM1114811	c.829G>T	p.E277*	Substitution - Nonsense	Endometrium
COSM1114769	c.2875G>T	p.G959*	Substitution - Nonsense	Endometrium
COSM3708428	c.530-4C>T	p.?	Unknown	Liver
COSM3557682	c.719C>A	p.P240Q	Substitution - Missense	Skin
COSM1465510	c.891_892insA	p.S298fs*14	Insertion - Frameshift	Large_intestine
COSM1114822	c.177A>C	p.K59N	Substitution - Missense	Endometrium
COSM255810	c.1714C>T	p.L572L	Substitution - coding silent	Central_nervous_system
COSM1569705	c.608A>G	p.N203S	Substitution - Missense	Large_intestine
COSM4589172	c.2013T>G	p.H671Q	Substitution - Missense	Bone
COSM5681062	c.2710G>A	p.E904K	Substitution - Missense	Soft_tissue
COSM363027	c.2754A>T	p.Q918H	Substitution - Missense	Lung
COSM5421036	c.1997_1998insA	p.Q667fs*14	Insertion - Frameshift	Prostate
COSM1114785	c.2147G>T	p.R716I	Substitution - Missense	Kidney
COSM1114787	c.1852C>T	p.R618C	Substitution - Missense	Endometrium
COSM4770921	c.705C>T	p.H235H	Substitution - coding silent	Pleura
COSM3738180	c.1449C>A	p.S483R	Substitution - Missense	Soft_tissue
COSM1465521	c.169_171delAAG	p.K57delK	Deletion - In frame	Biliary_tract
COSM367813	c.149C>A	p.T50K	Substitution - Missense	Lung
COSM3973225	c.1270C>T	p.R424*	Substitution - Nonsense	Central_nervous_system
COSM4892745	c.955G>A	p.E319K	Substitution - Missense	Skin
COSM1114767	c.2978G>A	p.R993Q	Substitution - Missense	Skin
COSM1465506	c.2783G>A	p.R928Q	Substitution - Missense	Large_intestine
COSM5951052	c.193C>T	p.Q65*	Substitution - Nonsense	Prostate
COSM2725350	c.2852G>A	p.R951H	Substitution - Missense	Large_intestine
COSM3701800	c.2443-6T>G	p.?	Unknown	Liver
COSM4901049	c.3076G>A	p.E1026K	Substitution - Missense	Skin
COSM3843510	c.2542G>C	p.E848Q	Substitution - Missense	Breast
COSM1756380	c.92C>G	p.P31R	Substitution - Missense	Urinary_tract
COSM1114767	c.2978G>A	p.R993Q	Substitution - Missense	Stomach
COSM4954000	c.95C>A	p.S32Y	Substitution - Missense	Liver
COSM4106535	c.2384G>A	p.R795H	Substitution - Missense	Stomach
COSM21740	c.1815+1G>A	p.?	Unknown	Skin
COSM1114775	c.2673C>A	p.S891S	Substitution - coding silent	Endometrium
COSM5617513	c.3129T>G	p.T1043T	Substitution - coding silent	Lung
COSM1490466	c.2665G>T	p.G889C	Substitution - Missense	Breast
COSM1756380	c.92C>G	p.P31R	Substitution - Missense	Urinary_tract
COSM3557678	c.2490A>G	p.E830E	Substitution - coding silent	Skin
COSM4106532	c.2774G>A	p.R925K	Substitution - Missense	Stomach
COSM3800395	c.1099-2A>G	p.?	Unknown	Urinary_tract
COSM755438	c.513T>A	p.F171L	Substitution - Missense	Lung
COSM1569705	c.608A>G	p.N203S	Substitution - Missense	Liver
COSM4106537	c.2038A>T	p.K680*	Substitution - Nonsense	Stomach
COSM2725377	c.1690A>G	p.N564D	Substitution - Missense	Large_intestine
COSM1114779	c.2590G>A	p.D864N	Substitution - Missense	Endometrium
COSM1114777	c.2654G>A	p.R885Q	Substitution - Missense	Endometrium
COSM4106533	c.2773A>G	p.R925G	Substitution - Missense	Stomach
COSM1114771	c.2867C>A	p.T956N	Substitution - Missense	Endometrium
COSM1569705	c.608A>G	p.N203S	Substitution - Missense	Liver
COSM251142	c.478G>A	p.E160K	Substitution - Missense	Liver
COSM4954000	c.95C>A	p.S32Y	Substitution - Missense	Liver
COSM755441	c.1957A>T	p.I653F	Substitution - Missense	Lung
COSM1114787	c.1852C>T	p.R618C	Substitution - Missense	Endometrium
COSM5411961	c.886G>A	p.E296K	Substitution - Missense	Skin
COSM4411470	c.1971_1972insTT	p.N658fs*12	Insertion - Frameshift	Kidney
COSM21740	c.1815+1G>A	p.?	Unknown	Skin
COSM755439	c.639G>T	p.G213G	Substitution - coding silent	Lung
COSM4486317	c.3036C>T	p.F1012F	Substitution - coding silent	Skin
COSM1727831	c.2427G>T	p.K809N	Substitution - Missense	Liver
COSM1465509	c.983G>A	p.R328H	Substitution - Missense	Large_intestine
COSM1490470	c.262-1G>C	p.?	Unknown	Breast
COSM5367013	c.399T>C	p.D133D	Substitution - coding silent	Large_intestine
COSM5700284	c.2010G>A	p.R670R	Substitution - coding silent	Soft_tissue
COSM1114813	c.668G>A	p.G223D	Substitution - Missense	Endometrium
COSM1190630	c.2312A>G	p.E771G	Substitution - Missense	Lung

> Text Mining based Variations [ TOP ]
There is no record for SMARCA1.

Summary
Symbol	SMARCA1
Name	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
Aliases	NURF140; SWI; hSNF2L; SNF2L1; SNF2L; SNF2LT; ATP-dependent helicase SMARCA1; SNF2-like 1; nucleosome-remodel ......
Location	Xq25-q26.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

[ TOP ]

Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
P28370	119	S	Phosphoserine	-	No	None detected
P28370	954	Y	Phosphotyrosine	-	No	None detected

Summary
Symbol	SMARCA1
Name	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
Aliases	NURF140; SWI; hSNF2L; SNF2L1; SNF2L; SNF2LT; ATP-dependent helicase SMARCA1; SNF2-like 1; nucleosome-remodel ......
Location	Xq25-q26.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	6.688	5.754	-0.905	0.00208	Under
BRCA	Breast invasive carcinoma	112	1100	6.353	5.674	-0.773	1.35e-10	Under
CESC	Cervical and endocervical cancers	3	306	6.624	4.563	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	3.544	2.707	-1.029	5.88e-06	Under
ESCA	Esophageal carcinoma	11	185	5.596	4.869	-0.951	0.0386	Under
GBM	Glioblastoma multiforme	5	166	6.082	6.213	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	4.558	4.573	-0.359	0.0911	NS
KIRC	Kidney renal clear cell carcinoma	72	534	6.422	5.744	-0.752	4.58e-22	Under
KIRP	Kidney renal papillary cell carcinoma	32	291	6.081	6.011	-0.251	0.0835	NS
LAML	Acute Myeloid Leukemia	0	173	NA	-1.388	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	6.49	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	6.454	6.134	-0.281	0.0497	NS
LUAD	Lung adenocarcinoma	59	517	5.785	6.154	0.389	0.00259	NS
LUSC	Lung squamous cell carcinoma	51	501	5.623	5.317	-0.395	0.00488	NS
OV	Ovarian serous cystadenocarcinoma	0	307	NA	5.111	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	5.935	5.718	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	7.663	6.984	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	6.783	6.534	-0.341	0.00393	NS
READ	Rectum adenocarcinoma	10	167	4.776	2.887	-1.672	0.000249	Under
SARC	Sarcoma	2	263	6.345	5.812	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	5.737	5.991	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	4.858	4.545	-0.627	0.00825	Under
TGCT	Testicular Germ Cell Tumors	0	156	NA	4.362	NA	NA	NA
THCA	Thyroid carcinoma	59	509	7.159	6.631	-0.472	1.4e-10	NS
THYM	Thymoma	2	120	4.826	5.464	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	6.203	5.631	-0.88	5.67e-06	Under

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	22.5
Adrenal gland	106.9
Appendix	13.2
Bone marrow	0.2
Breast	26.6
Cerebral cortex	34.2
Cervix, uterine	44.8
Colon	7.4
Duodenum	7.1
Endometrium	47.7
Epididymis	42.1
Esophagus	13.4
Fallopian tube	34.5
Gallbladder	36
Heart muscle	17.6
Kidney	26.8
Liver	33.6
Lung	25.7
Lymph node	5.4
Ovary	92.4
Pancreas	3.5
Parathyroid gland	98.4
Placenta	57.1
Prostate	59.7
Rectum	8.2
Salivary gland	8.2
Seminal vesicle	52
Skeletal muscle	6.3
Skin	10
Small intestine	7.2
Smooth muscle	39.2
Spleen	13
Stomach	17.2
Testis	112.7
Thyroid gland	80.2
Tonsil	4.3
Urinary bladder	29.6

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
27340867	Loss of Expression	Ovarian Carcinoma	Cases which lack at least one SWI/SNF complex component exhibited significantly more advanced stages, faster growth and stronger nuclear atypia compared with SWI/SNF-positive samples (p<0.05).
26345631	Loss of expression	Non-Small Cell Lung Cancer	Collectively, these results indicate that the loss of the SWI/SNF complex was related to dedifferentiation in NSCLC.
26126041	Loss of expression	Endometrial Carcinoma	Abnormal SWI/SNF subunit expression was detected in four dedifferentiated carcinomas including three with loss of BRG1 staining limited to the undifferentiated tumour component and one case with loss of INI1 expression in both low- and high-grade elements; the latter case also showed BAF250a deficiency in the undifferentiated tumour cells.
27339451	Aberrant expression	Urothelial Carcinoma	Our results are in line with recent studies reporting involvement of the SWI/SNF complex in the dedifferentiation process of a variety of epithelial neoplasms in different organs, including the urinary tract, and association with aggressive clinical course.
27984237	Loss of expression	Renal Cell Carcinoma	Variable loss of at least 1 SWI/SNF complex subunit was noted in the undifferentiated/rhabdoid component of 21/32 cases (65%) compared with intact or reduced expression in the differentiated component.

Summary
Symbol	SMARCA1
Name	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
Aliases	NURF140; SWI; hSNF2L; SNF2L1; SNF2L; SNF2LT; ATP-dependent helicase SMARCA1; SNF2-like 1; nucleosome-remodel ......
Location	Xq25-q26.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.151	0.0023	20.5	64.6	14.9	Neutral
BRCA	Breast invasive carcinoma	1075	0.021	0.484	17.9	67.6	14.5	Neutral
CESC	Cervical and endocervical cancers	292	0.156	0.00738	19.2	62.3	18.5	Neutral
COAD	Colon adenocarcinoma	449	-0.039	0.415	11.1	69.9	18.9	Neutral
ESCA	Esophageal carcinoma	183	0.083	0.263	14.2	52.5	33.3	Neutral
GBM	Glioblastoma multiforme	147	0.264	0.00125	25.2	70.1	4.8	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.155	0.000434	11.7	64.4	23.9	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.232	7.79e-08	10.1	84.8	5.1	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.172	0.00344	10.1	58	31.9	Neutral
LAML	Acute Myeloid Leukemia	166	0.121	0.122	3.6	95.8	0.6	Neutral
LGG	Brain Lower Grade Glioma	513	0.101	0.0217	15	76.4	8.6	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.087	0.096	17.6	61.8	20.6	Neutral
LUAD	Lung adenocarcinoma	512	0.081	0.0656	10.5	64.1	25.4	Neutral
LUSC	Lung squamous cell carcinoma	498	0.179	5.79e-05	21.1	58	20.9	Neutral
OV	Ovarian serous cystadenocarcinoma	300	0.161	0.00532	40.3	29.7	30	Loss
PAAD	Pancreatic adenocarcinoma	177	0.162	0.0314	10.7	79.7	9.6	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.034	0.671	31.5	65.4	3.1	Neutral
PRAD	Prostate adenocarcinoma	491	0.032	0.477	6.5	90.4	3.1	Neutral
READ	Rectum adenocarcinoma	164	-0.108	0.168	15.2	64	20.7	Neutral
SARC	Sarcoma	255	0.295	1.68e-06	50.6	40.8	8.6	Loss
SKCM	Skin Cutaneous Melanoma	367	0.163	0.00177	25.3	61.3	13.4	Neutral
STAD	Stomach adenocarcinoma	413	-0.052	0.288	10.9	71.4	17.7	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.125	0.127	19.3	64.7	16	Neutral
THCA	Thyroid carcinoma	497	-0.011	0.807	0.8	97.6	1.6	Neutral
THYM	Thymoma	119	0.241	0.00841	4.2	90.8	5	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.171	6.55e-05	14.2	71.9	14	Neutral

Summary
Symbol	SMARCA1
Name	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
Aliases	NURF140; SWI; hSNF2L; SNF2L1; SNF2L; SNF2LT; ATP-dependent helicase SMARCA1; SNF2-like 1; nucleosome-remodel ......
Location	Xq25-q26.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.459	0	17	408	0.173	0.000335	NS/NA
BRCA	Breast invasive carcinoma	-0.388	0	83	785	0.069	3.79e-16	NS/NA
CESC	Cervical and endocervical cancers	-0.428	0	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.317	1.02e-08	19	297	0.287	0.00121	Increased
ESCA	Esophageal carcinoma	-0.541	0	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.157	0.21	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.451	0	20	522	0.189	7.6e-10	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.291	4.52e-08	24	319	0.244	3.9e-14	Increased
KIRP	Kidney renal papillary cell carcinoma	-0.278	1.2e-06	23	275	0.064	1.58e-06	NS/NA
LAML	Acute Myeloid Leukemia	-0.594	0	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.122	0.00486	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.238	1.04e-06	41	373	-0.07	0.0355	NS/NA
LUAD	Lung adenocarcinoma	-0.46	0	21	456	0.067	0.000235	NS/NA
LUSC	Lung squamous cell carcinoma	-0.47	0	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.467	0.213	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.353	1.16e-06	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	0	1	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.298	2.59e-12	35	498	0.276	2.25e-37	Increased
READ	Rectum adenocarcinoma	-0.417	1.76e-05	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.411	5.04e-12	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.461	0	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.524	0	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.426	3.93e-08	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.154	0.000272	50	509	0.032	0.00472	NS/NA
THYM	Thymoma	-0.735	0	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.363	6.58e-16	34	431	0.123	3.58e-20	NS/NA

Summary
Symbol	SMARCA1
Name	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
Aliases	NURF140; SWI; hSNF2L; SNF2L1; SNF2L; SNF2LT; ATP-dependent helicase SMARCA1; SNF2-like 1; nucleosome-remodel ......
Location	Xq25-q26.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	0	Not detected
Appendix	0	Not detected
Bone marrow	1	Low
Breast	2	Medium
Bronchus	0	Not detected
Caudate	2	Medium
Cerebellum	2	Medium
Cerebral cortex	2	Medium
Cervix, uterine	0	Not detected
Colon	0	Not detected
Duodenum	1	Low
Endometrium	0	Not detected
Epididymis	0	Not detected
Esophagus	1	Low
Fallopian tube	0	Not detected
Gallbladder	0	Not detected
Heart muscle	1	Low
Hippocampus	2	Medium
Kidney	0	Not detected
Liver	0	Not detected
Lung	2	Medium
Lymph node	0	Not detected
Nasopharynx	0	Not detected
Oral mucosa	0	Not detected
Ovary	0	Not detected
Pancreas	1	Low
Parathyroid gland	1	Low
Placenta	0	Not detected
Prostate	1	Low
Rectum	0	Not detected
Salivary gland	0	Not detected
Skeletal muscle	0	Not detected
Skin	1	Low
Small intestine	1	Low
Smooth muscle	0	Not detected
Soft tissue	0	Not detected
Spleen	0	Not detected
Stomach	1	Low
Testis	2	Medium
Thyroid gland	0	Not detected
Tonsil	0	Not detected
Urinary bladder	0	Not detected
Vagina	0	Not detected

Summary
Symbol	SMARCA1
Name	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
Aliases	NURF140; SWI; hSNF2L; SNF2L1; SNF2L; SNF2LT; ATP-dependent helicase SMARCA1; SNF2-like 1; nucleosome-remodel ......
Location	Xq25-q26.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.136	NS	24476821
BRCA	Breast invasive carcinoma	521	0.016	Significant	23000897
COAD	Colon adenocarcinoma	149	0.132	NS	22810696
GBM	Glioblastoma multiforme	157	0.0777	NS	26824661
HNSC	Head and Neck squamous cell carcinoma	279	1.55e-07	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.151	NS	26536169
LGG	Brain Lower Grade Glioma	513	1.26e-18	Significant	26824661
LUAD	Lung adenocarcinoma	230	7.63e-07	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	0.164	NS	22960745
OV	Ovarian serous cystadenocarcinoma	287	2.33e-10	Significant	21720365
PRAD	Prostate adenocarcinoma	333	0.00548	Significant	26544944
READ	Rectum adenocarcinoma	67	0.733	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.0478	Significant	26091043
STAD	Stomach adenocarcinoma	277	1.29e-09	Significant	25079317
THCA	Thyroid carcinoma	391	4.6e-17	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.00163	Significant	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	1.447	0.0901	NS
BRCA	Breast invasive carcinoma	1079	1.193	0.45	NS
CESC	Cervical and endocervical cancers	291	2.508	0.0092	Shorter
COAD	Colon adenocarcinoma	439	1.239	0.444	NS
ESCA	Esophageal carcinoma	184	0.875	0.655	NS
GBM	Glioblastoma multiforme	158	0.824	0.452	NS
HNSC	Head and Neck squamous cell carcinoma	518	1.237	0.254	NS
KIRC	Kidney renal clear cell carcinoma	531	0.477	0.000569	Longer
KIRP	Kidney renal papillary cell carcinoma	287	0.66	0.336	NS
LAML	Acute Myeloid Leukemia	149	0.905	0.748	NS
LGG	Brain Lower Grade Glioma	511	1.505	0.126	NS
LIHC	Liver hepatocellular carcinoma	365	1.007	0.977	NS
LUAD	Lung adenocarcinoma	502	1.473	0.0691	NS
LUSC	Lung squamous cell carcinoma	494	0.958	0.83	NS
OV	Ovarian serous cystadenocarcinoma	303	1.173	0.449	NS
PAAD	Pancreatic adenocarcinoma	177	0.698	0.209	NS
PCPG	Pheochromocytoma and Paraganglioma	179	5.015	0.124	NS
PRAD	Prostate adenocarcinoma	497	1.753	0.535	NS
READ	Rectum adenocarcinoma	159	0.733	0.611	NS
SARC	Sarcoma	259	1.509	0.129	NS
SKCM	Skin Cutaneous Melanoma	459	0.926	0.693	NS
STAD	Stomach adenocarcinoma	388	2.525	0.000103	Shorter
TGCT	Testicular Germ Cell Tumors	134	0	0.27	NS
THCA	Thyroid carcinoma	500	0.672	0.536	NS
THYM	Thymoma	119	2.091	0.375	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	1.528	0.172	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	0.074	0.134	NS
BRCA	Breast invasive carcinoma	1071	-0.075	0.0146	Lower
CESC	Cervical and endocervical cancers	167	-0.12	0.122	NS
COAD	Colon adenocarcinoma	445	0.135	0.00425	Higher
ESCA	Esophageal carcinoma	162	0.017	0.833	NS
HNSC	Head and Neck squamous cell carcinoma	448	0.043	0.366	NS
KIRC	Kidney renal clear cell carcinoma	531	-0.209	1.19e-06	Lower
KIRP	Kidney renal papillary cell carcinoma	260	-0.166	0.00732	Lower
LIHC	Liver hepatocellular carcinoma	347	-0.033	0.536	NS
LUAD	Lung adenocarcinoma	507	0.083	0.0634	NS
LUSC	Lung squamous cell carcinoma	497	0.065	0.148	NS
OV	Ovarian serous cystadenocarcinoma	302	-0.073	0.207	NS
PAAD	Pancreatic adenocarcinoma	176	-0.127	0.0919	NS
READ	Rectum adenocarcinoma	156	0.178	0.0264	Higher
SKCM	Skin Cutaneous Melanoma	410	-0.013	0.795	NS
STAD	Stomach adenocarcinoma	392	0.093	0.0662	NS
TGCT	Testicular Germ Cell Tumors	81	0.333	0.00238	Higher
THCA	Thyroid carcinoma	499	-0.153	0.000594	Lower
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.038	0.396	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	0.035	0.566	NS
HNSC	Head and Neck squamous cell carcinoma	498	0.118	0.00845	Higher
KIRC	Kidney renal clear cell carcinoma	525	-0.259	1.79e-09	Lower
LGG	Brain Lower Grade Glioma	514	0.022	0.624	NS
LIHC	Liver hepatocellular carcinoma	366	0.013	0.807	NS
OV	Ovarian serous cystadenocarcinoma	296	-0.061	0.297	NS
PAAD	Pancreatic adenocarcinoma	176	-0.026	0.733	NS
STAD	Stomach adenocarcinoma	406	0.019	0.697	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.087	0.0438	Higher

Summary
Symbol	SMARCA1
Name	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
Aliases	NURF140; SWI; hSNF2L; SNF2L1; SNF2L; SNF2LT; ATP-dependent helicase SMARCA1; SNF2-like 1; nucleosome-remodel ......
Location	Xq25-q26.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	SMARCA1
Name	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
Aliases	NURF140; SWI; hSNF2L; SNF2L1; SNF2L; SNF2LT; ATP-dependent helicase SMARCA1; SNF2-like 1; nucleosome-remodel ......
Location	Xq25-q26.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for SMARCA1.

Summary
Symbol	SMARCA1
Name	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
Aliases	NURF140; SWI; hSNF2L; SNF2L1; SNF2L; SNF2LT; ATP-dependent helicase SMARCA1; SNF2-like 1; nucleosome-remodel ......
Location	Xq25-q26.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
27340867	Ovarian Carcinoma	partner	SNF	Complex formation	Cases which lack at least one SWI/SNF complex component exhibited significantly more advanced stages, faster growth and stronger nuclear atypia compared with SWI/SNF-positive samples (p<0.05).
26812616	Oesophagal Squamous Cell Carcinoma	partner	SNF	Complex formation	These results showed that genetic and epigenetic alterations of the SWI/SNF complex are present in ESCCs, and suggested that genetic alterations are induced at an early stage of esophageal squamous cell carcinogenesis.
26345631	Non-Small Cell Lung Cancer	partner	SNF	Complex formation	Collectively, these results indicate that the loss of the SWI/SNF complex was related to dedifferentiation in NSCLC.
26126041	Endometrial Carcinoma	partner	SNF	Complex formation	Abnormal SWI/SNF subunit expression was detected in four dedifferentiated carcinomas including three with loss of BRG1 staining limited to the undifferentiated tumour component and one case with loss of INI1 expression in both low- and high-grade elements; the latter case also showed BAF250a deficiency in the undifferentiated tumour cells.
27339451	Urothelial Carcinoma	partner	SNF	Complex formation	Our results are in line with recent studies reporting involvement of the SWI/SNF complex in the dedifferentiation process of a variety of epithelial neoplasms in different organs, including the urinary tract, and association with aggressive clinical course.