CR2Cancer

Summary
Symbol	SMARCC1
Name	SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1
Aliases	BAF155; SRG3; CRACC1; SWI3; BRG1-associated factor 155; SWI/SNF complex 155 kDa subunit; SWI/SNF-related mat ......
Location	3p21.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

[ TOP ]

Domain

PF00249 Myb-like DNA-binding domain
PF04433 SWIRM domain
PF16495 SWIRM-associated region 1
PF16496 SWIRM-associated domain at the N-terminal
PF16498 SWIRM-associated domain at the C-terminal

Function

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). May stimulate the ATPase activity of the catalytic subunit of the complex. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).

Classification

Class	Modification	Substrate	Product	PubMed
Chromatin remodelling cofactor	#	#	#	10078207

> Gene Ontology [ TOP ]
Biological Process	GO:0001655 urogenital system development GO:0006333 chromatin assembly or disassembly GO:0006337 nucleosome disassembly GO:0006338 chromatin remodeling GO:0008286 insulin receptor signaling pathway GO:0009894 regulation of catabolic process GO:0009895 negative regulation of catabolic process GO:0010498 proteasomal protein catabolic process GO:0030850 prostate gland development GO:0031329 regulation of cellular catabolic process GO:0031330 negative regulation of cellular catabolic process GO:0031498 chromatin disassembly GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032868 response to insulin GO:0032869 cellular response to insulin stimulus GO:0032984 macromolecular complex disassembly GO:0032986 protein-DNA complex disassembly GO:0034728 nucleosome organization GO:0042176 regulation of protein catabolic process GO:0042177 negative regulation of protein catabolic process GO:0043044 ATP-dependent chromatin remodeling GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043241 protein complex disassembly GO:0043434 response to peptide hormone GO:0045861 negative regulation of proteolysis GO:0048608 reproductive structure development GO:0048732 gland development GO:0061136 regulation of proteasomal protein catabolic process GO:0061458 reproductive system development GO:0071375 cellular response to peptide hormone stimulus GO:0071417 cellular response to organonitrogen compound GO:0071824 protein-DNA complex subunit organization GO:1901652 response to peptide GO:1901653 cellular response to peptide GO:1901799 negative regulation of proteasomal protein catabolic process GO:1903050 regulation of proteolysis involved in cellular protein catabolic process GO:1903051 negative regulation of proteolysis involved in cellular protein catabolic process GO:1903362 regulation of cellular protein catabolic process GO:1903363 negative regulation of cellular protein catabolic process
Molecular Function	GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000987 core promoter proximal region sequence-specific DNA binding GO:0001158 enhancer sequence-specific DNA binding GO:0001159 core promoter proximal region DNA binding GO:0003682 chromatin binding GO:0003713 transcription coactivator activity GO:0031490 chromatin DNA binding GO:0031491 nucleosome binding GO:0031492 nucleosomal DNA binding GO:0035326 enhancer binding GO:0043566 structure-specific DNA binding GO:0047485 protein N-terminus binding
Cellular Component	GO:0000785 chromatin GO:0000790 nuclear chromatin GO:0000803 sex chromosome GO:0001741 XY body GO:0016514 SWI/SNF complex GO:0044454 nuclear chromosome part GO:0070603 SWI/SNF superfamily-type complex GO:0071564 npBAF complex GO:0071565 nBAF complex GO:0090544 BAF-type complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-3214858: RMTs methylate histone arginines

Summary
Symbol	SMARCC1
Name	SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1
Aliases	BAF155; SRG3; CRACC1; SWI3; BRG1-associated factor 155; SWI/SNF complex 155 kDa subunit; SWI/SNF-related mat ......
Location	3p21.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM3069604	c.3067A>G	p.M1023V	Substitution - Missense	Breast
COSM3365204	c.1894C>G	p.L632V	Substitution - Missense	Kidney
COSM1423622	c.3131C>T	p.S1044F	Substitution - Missense	Large_intestine
COSM419977	c.850G>A	p.D284N	Substitution - Missense	Breast
COSM4118103	c.325T>C	p.F109L	Substitution - Missense	Stomach
COSM4118097	c.1496G>A	p.R499H	Substitution - Missense	Stomach
COSM1168999	c.2472G>A	p.V824V	Substitution - coding silent	Pancreas
COSM21744	c.1495C>T	p.R499C	Substitution - Missense	Large_intestine
COSM5030671	c.1783_1790delGATTTGCA	p.D595fs*7	Deletion - Frameshift	Bone
COSM1186275	c.3010C>T	p.H1004Y	Substitution - Missense	Lung
COSM1045656	c.2016G>T	p.E672D	Substitution - Missense	Endometrium
COSM446633	c.1561G>T	p.A521S	Substitution - Missense	Breast
COSM4524148	c.1256G>A	p.G419E	Substitution - Missense	Skin
COSM3069640	c.1586delT	p.L529fs*1	Deletion - Frameshift	Large_intestine
COSM392268	c.2441_2444delAAAA	p.K814fs*10	Deletion - Frameshift	Lung
COSM3380608	c.2051A>G	p.Q684R	Substitution - Missense	Pancreas
COSM4996349	c.2927G>C	p.G976A	Substitution - Missense	Upper_aerodigestive_tract
COSM3760136	c.1845A>G	p.K615K	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM235408	c.2175C>T	p.V725V	Substitution - coding silent	Large_intestine
COSM4754484	c.3302C>A	p.A1101D	Substitution - Missense	Stomach
COSM3069667	c.690A>G	p.L230L	Substitution - coding silent	Large_intestine
COSM3916182	c.2990C>T	p.P997L	Substitution - Missense	Skin
COSM4488365	c.3313C>T	p.P1105S	Substitution - Missense	Skin
COSM5447565	c.321G>A	p.K107K	Substitution - coding silent	Large_intestine
COSM396763	c.1141G>A	p.E381K	Substitution - Missense	Lung
COSM4653704	c.879T>C	p.P293P	Substitution - coding silent	Large_intestine
COSM1309203	c.2551G>A	p.D851N	Substitution - Missense	Urinary_tract
COSM1757091	c.3305C>T	p.S1102L	Substitution - Missense	Urinary_tract
COSM1734697	c.402-3delT	p.?	Unknown	Biliary_tract
COSM3824032	c.2506G>A	p.E836K	Substitution - Missense	Breast
COSM4885737	c.1593G>C	p.Q531H	Substitution - Missense	Upper_aerodigestive_tract
COSM5733656	c.1753T>A	p.F585I	Substitution - Missense	Pancreas
COSM3594791	c.3274C>T	p.P1092S	Substitution - Missense	Skin
COSM4486986	c.3128C>T	p.P1043L	Substitution - Missense	Skin
COSM1045668	c.1472G>A	p.R491Q	Substitution - Missense	Endometrium
COSM6010964	c.34A>G	p.T12A	Substitution - Missense	Skin
COSM4728322	c.3140G>A	p.G1047D	Substitution - Missense	Large_intestine
COSM4324744	c.1298G>C	p.R433P	Substitution - Missense	Upper_aerodigestive_tract
COSM5502694	c.1089G>A	p.E363E	Substitution - coding silent	Biliary_tract
COSM292606	c.2860G>A	p.A954T	Substitution - Missense	Skin
COSM1495556	c.2490A>G	p.S830S	Substitution - coding silent	Kidney
COSM3824033	c.2023G>A	p.D675N	Substitution - Missense	Breast
COSM4118098	c.1468T>C	p.Y490H	Substitution - Missense	Stomach
COSM1045674	c.1180G>T	p.D394Y	Substitution - Missense	Endometrium
COSM1045668	c.1472G>A	p.R491Q	Substitution - Missense	Central_nervous_system
COSM5813155	c.2433A>T	p.E811D	Substitution - Missense	Liver
COSM5742954	c.1672G>A	p.V558I	Substitution - Missense	Small_intestine
COSM4185646	c.1705C>A	p.L569M	Substitution - Missense	Kidney
COSM3069632	c.2211T>C	p.H737H	Substitution - coding silent	Bone
COSM357592	c.1176G>T	p.K392N	Substitution - Missense	Lung
COSM4754489	c.2356G>C	p.D786H	Substitution - Missense	Stomach
COSM4728324	c.1689delC	p.S564fs*20	Deletion - Frameshift	Large_intestine
COSM1045644	c.2840_2881del42	p.L947_Q960del14	Deletion - In frame	Endometrium
COSM1045678	c.852T>G	p.D284E	Substitution - Missense	Endometrium
COSM1045654	c.2518G>T	p.E840*	Substitution - Nonsense	Endometrium
COSM4996350	c.206C>T	p.A69V	Substitution - Missense	Upper_aerodigestive_tract
COSM4642780	c.1916A>G	p.K639R	Substitution - Missense	Large_intestine
COSM247464	c.3213C>T	p.N1071N	Substitution - coding silent	Prostate
COSM4459657	c.1134C>T	p.P378P	Substitution - coding silent	Skin
COSM4118095	c.2817C>T	p.R939R	Substitution - coding silent	Stomach
COSM446631	c.2607C>G	p.A869A	Substitution - coding silent	Breast
COSM3594803	c.250C>T	p.L84F	Substitution - Missense	Skin
COSM5025942	c.842_845delATGA	p.N281fs*13	Deletion - Frameshift	Breast
COSM308427	c.1840-3T>C	p.?	Unknown	Kidney
COSM4525429	c.132G>C	p.E44D	Substitution - Missense	Skin
COSM1728575	c.1198G>C	p.V400L	Substitution - Missense	Liver
COSM4118094	c.2857C>T	p.R953*	Substitution - Nonsense	Stomach
COSM4409072	c.3043+4A>T	p.?	Unknown	Oesophagus
COSM419976	c.760G>A	p.E254K	Substitution - Missense	Urinary_tract
COSM1423627	c.443A>T	p.N148I	Substitution - Missense	Large_intestine
COSM3594795	c.1310T>G	p.L437R	Substitution - Missense	Skin
COSM1734697	c.402-3delT	p.?	Unknown	Prostate
COSM1045664	c.1657A>G	p.T553A	Substitution - Missense	Endometrium
COSM4728325	c.498delC	p.R167fs*12	Deletion - Frameshift	Large_intestine
COSM5974817	c.348C>A	p.G116G	Substitution - coding silent	Upper_aerodigestive_tract
COSM4118096	c.1869G>A	p.W623*	Substitution - Nonsense	Stomach
COSM1642287	c.890G>A	p.R297H	Substitution - Missense	Stomach
COSM4118099	c.1348A>G	p.I450V	Substitution - Missense	Stomach
COSM4118101	c.1003A>G	p.T335A	Substitution - Missense	Stomach
COSM1045666	c.1535G>A	p.R512Q	Substitution - Missense	Endometrium
COSM1226782	c.1708C>T	p.H570Y	Substitution - Missense	Large_intestine
COSM5965471	c.1237G>A	p.E413K	Substitution - Missense	Breast
COSM446634	c.1554T>C	p.D518D	Substitution - coding silent	Breast
COSM730684	c.1108G>T	p.D370Y	Substitution - Missense	Lung
COSM3594792	c.3189C>T	p.P1063P	Substitution - coding silent	Skin
COSM21744	c.1495C>T	p.R499C	Substitution - Missense	Skin
COSM1670143	c.1696C>A	p.L566I	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4805931	c.1809T>C	p.T603T	Substitution - coding silent	Liver
COSM3760136	c.1845A>G	p.K615K	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM1617696	c.1385+4A>T	p.?	Unknown	Liver
COSM4118093	c.2877A>G	p.E959E	Substitution - coding silent	Stomach
COSM446632	c.2332G>C	p.E778Q	Substitution - Missense	Breast
COSM1226785	c.2090G>A	p.S697N	Substitution - Missense	Large_intestine
COSM1633206	c.1367C>G	p.S456*	Substitution - Nonsense	Liver
COSM4152464	c.2674A>G	p.I892V	Substitution - Missense	Kidney
COSM5736596	c.2176C>T	p.R726W	Substitution - Missense	Small_intestine
COSM1753242	c.3003G>C	p.L1001L	Substitution - coding silent	Urinary_tract
COSM1617695	c.1687C>T	p.P563S	Substitution - Missense	Liver
COSM25284	c.1928A>T	p.N643I	Substitution - Missense	Lung
COSM235408	c.2175C>T	p.V725V	Substitution - coding silent	Skin
COSM4584411	c.862G>A	p.D288N	Substitution - Missense	Bone
COSM419977	c.850G>A	p.D284N	Substitution - Missense	Urinary_tract
COSM3380608	c.2051A>G	p.Q684R	Substitution - Missense	Pancreas
COSM3945531	c.2889T>C	p.H963H	Substitution - coding silent	Lung
COSM4981088	c.2346A>C	p.E782D	Substitution - Missense	Oesophagus
COSM5437357	c.2398G>A	p.E800K	Substitution - Missense	Oesophagus
COSM121906	c.2301C>G	p.P767P	Substitution - coding silent	Oesophagus
COSM4158093	c.2426A>C	p.D809A	Substitution - Missense	Thyroid
COSM4791792	c.366T>A	p.L122L	Substitution - coding silent	Liver
COSM1753242	c.3003G>C	p.L1001L	Substitution - coding silent	Urinary_tract
COSM1692721	c.2168C>T	p.S723F	Substitution - Missense	Skin
COSM3069638	c.1804C>T	p.R602C	Substitution - Missense	Prostate
COSM1734697	c.402-3delT	p.?	Unknown	Pancreas
COSM5974817	c.348C>A	p.G116G	Substitution - coding silent	Upper_aerodigestive_tract
COSM1664273	c.439C>G	p.R147G	Substitution - Missense	Kidney
COSM3594798	c.788G>A	p.W263*	Substitution - Nonsense	Skin
COSM1045662	c.1714C>T	p.R572*	Substitution - Nonsense	Endometrium
COSM3594797	c.994C>T	p.P332S	Substitution - Missense	Skin
COSM4805931	c.1809T>C	p.T603T	Substitution - coding silent	Liver
COSM1734697	c.402-3delT	p.?	Unknown	Prostate
COSM21744	c.1495C>T	p.R499C	Substitution - Missense	Skin
COSM4805985	c.1816T>G	p.Y606D	Substitution - Missense	Liver
COSM5350991	c.1301C>T	p.S434L	Substitution - Missense	Lung
COSM1045682	c.569G>A	p.R190Q	Substitution - Missense	Endometrium
COSM4961307	c.3044-1G>A	p.?	Unknown	Liver
COSM1045652	c.2530A>G	p.T844A	Substitution - Missense	Endometrium
COSM4475291	c.1978C>T	p.H660Y	Substitution - Missense	Skin
COSM1266247	c.2531C>T	p.T844I	Substitution - Missense	Stomach
COSM4118102	c.440G>A	p.R147H	Substitution - Missense	Stomach
COSM1617695	c.1687C>T	p.P563S	Substitution - Missense	Liver
COSM3594794	c.1660C>T	p.P554S	Substitution - Missense	Skin
COSM1226784	c.2424A>C	p.Q808H	Substitution - Missense	Large_intestine
COSM5797680	c.1937C>G	p.S646W	Substitution - Missense	Breast
COSM1266246	c.3181T>G	p.L1061V	Substitution - Missense	Oesophagus
COSM1045660	c.1805G>A	p.R602H	Substitution - Missense	Endometrium
COSM4889444	c.1040G>T	p.G347V	Substitution - Missense	Upper_aerodigestive_tract
COSM5796593	c.2608G>C	p.A870P	Substitution - Missense	Breast
COSM730686	c.1205G>T	p.G402V	Substitution - Missense	Lung
COSM5885654	c.2562G>C	p.K854N	Substitution - Missense	Urinary_tract
COSM4962923	c.1264-4A>G	p.?	Unknown	Pancreas
COSM357339	c.772A>G	p.I258V	Substitution - Missense	Lung
COSM4931930	c.2870A>G	p.Q957R	Substitution - Missense	Liver
COSM25284	c.1928A>T	p.N643I	Substitution - Missense	Lung
COSM25284	c.1928A>T	p.N643I	Substitution - Missense	Lung
COSM1045672	c.1197T>C	p.P399P	Substitution - coding silent	Endometrium
COSM1045670	c.1371G>T	p.W457C	Substitution - Missense	Endometrium
COSM5763460	c.1386-8C>T	p.?	Unknown	Large_intestine
COSM1726404	c.1715G>A	p.R572Q	Substitution - Missense	Liver
COSM5746117	c.1436delA	p.N479fs*16	Deletion - Frameshift	Pancreas
COSM4406245	c.1199T>G	p.V400G	Substitution - Missense	Skin
COSM21744	c.1495C>T	p.R499C	Substitution - Missense	Large_intestine
COSM5795562	c.1165+10C>T	p.?	Unknown	Breast
COSM5912006	c.1840-5C>T	p.?	Unknown	Skin
COSM3408713	c.732C>T	p.V244V	Substitution - coding silent	Central_nervous_system
COSM3916183	c.2121C>T	p.D707D	Substitution - coding silent	Skin
COSM315437	c.2021C>T	p.S674L	Substitution - Missense	Soft_tissue
COSM109965	c.3147C>T	p.T1049T	Substitution - coding silent	Skin
COSM4961307	c.3044-1G>A	p.?	Unknown	Liver
COSM5202422	c.2105_2106insT	p.L702fs*34	Insertion - Frameshift	Breast
COSM5355181	c.1000C>T	p.P334S	Substitution - Missense	Large_intestine
COSM4391655	c.2171G>A	p.R724Q	Substitution - Missense	Breast
COSM1045648	c.2682C>T	p.S894S	Substitution - coding silent	Endometrium
COSM4908524	c.1672G>T	p.V558L	Substitution - Missense	Kidney
COSM4118100	c.1243A>G	p.T415A	Substitution - Missense	Stomach
COSM5570741	c.41T>G	p.V14G	Substitution - Missense	Prostate
COSM121906	c.2301C>G	p.P767P	Substitution - coding silent	Upper_aerodigestive_tract
COSM5437356	c.2407G>A	p.E803K	Substitution - Missense	Oesophagus
COSM730687	c.1926G>C	p.W642C	Substitution - Missense	Lung
COSM3380608	c.2051A>G	p.Q684R	Substitution - Missense	Pancreas
COSM4470713	c.1679C>T	p.A560V	Substitution - Missense	Skin
COSM1617696	c.1385+4A>T	p.?	Unknown	Liver
COSM1757092	c.2476G>A	p.E826K	Substitution - Missense	Urinary_tract
COSM3380607	c.2845T>C	p.Y949H	Substitution - Missense	Pancreas
COSM315437	c.2021C>T	p.S674L	Substitution - Missense	Lung
COSM5014335	c.2320+1G>T	p.?	Unknown	Kidney
COSM4728323	c.3077G>C	p.G1026A	Substitution - Missense	Large_intestine
COSM1328194	c.2242T>C	p.S748P	Substitution - Missense	Ovary
COSM1692722	c.2059_2060CC>TT	p.P687F	Substitution - Missense	Skin
COSM5399494	c.3127C>T	p.P1043S	Substitution - Missense	Skin
COSM1045654	c.2518G>T	p.E840*	Substitution - Nonsense	Large_intestine
COSM357592	c.1176G>T	p.K392N	Substitution - Missense	Stomach
COSM3069687	c.135C>T	p.S45S	Substitution - coding silent	Bone
COSM4791792	c.366T>A	p.L122L	Substitution - coding silent	Liver
COSM4118092	c.3252A>G	p.P1084P	Substitution - coding silent	Stomach
COSM1226781	c.1954C>T	p.R652C	Substitution - Missense	Large_intestine
COSM5399495	c.2988C>T	p.P996P	Substitution - coding silent	Skin
COSM4474080	c.1893C>T	p.L631L	Substitution - coding silent	Skin
COSM4158094	c.2425G>T	p.D809Y	Substitution - Missense	Thyroid
COSM3974444	c.1957A>G	p.T653A	Substitution - Missense	Central_nervous_system
COSM5399497	c.1120C>T	p.P374S	Substitution - Missense	Skin
COSM4805985	c.1816T>G	p.Y606D	Substitution - Missense	Liver
COSM1045668	c.1472G>A	p.R491Q	Substitution - Missense	Stomach
COSM3594802	c.539T>C	p.L180S	Substitution - Missense	Skin
COSM1757092	c.2476G>A	p.E826K	Substitution - Missense	Urinary_tract
COSM3594796	c.1250C>T	p.T417I	Substitution - Missense	Skin
COSM1757093	c.1276C>T	p.P426S	Substitution - Missense	Urinary_tract
COSM1045646	c.2759T>G	p.I920S	Substitution - Missense	Endometrium
COSM5344494	c.1406G>A	p.R469H	Substitution - Missense	Large_intestine
COSM3760136	c.1845A>G	p.K615K	Substitution - coding silent	Large_intestine
COSM4541643	c.3043G>A	p.G1015S	Substitution - Missense	Skin
COSM1045658	c.1847G>T	p.G616V	Substitution - Missense	Endometrium
COSM4152465	c.433A>T	p.M145L	Substitution - Missense	Kidney
COSM5399496	c.1581C>T	p.A527A	Substitution - coding silent	Skin
COSM1045642	c.2883G>A	p.Q961Q	Substitution - coding silent	Endometrium
COSM3069621	c.2444delA	p.N815fs*10	Deletion - Frameshift	Large_intestine
COSM1423626	c.823_824delAT	p.I275fs*3	Deletion - Frameshift	Large_intestine
COSM337119	c.2120A>T	p.D707V	Substitution - Missense	Lung
COSM5355181	c.1000C>T	p.P334S	Substitution - Missense	Large_intestine
COSM730685	c.1165+1G>T	p.?	Unknown	Lung
COSM292606	c.2860G>A	p.A954T	Substitution - Missense	Large_intestine
COSM5892924	c.2989C>T	p.P997S	Substitution - Missense	Skin
COSM5577754	c.2606C>T	p.A869V	Substitution - Missense	Skin
COSM4820696	c.1986G>C	p.L662F	Substitution - Missense	Cervix
COSM1757093	c.1276C>T	p.P426S	Substitution - Missense	Urinary_tract
COSM1226783	c.1075A>G	p.K359E	Substitution - Missense	Large_intestine
COSM3594793	c.2317C>G	p.L773V	Substitution - Missense	Skin
COSM5892924	c.2989C>T	p.P997S	Substitution - Missense	Skin
COSM1045650	c.2541A>G	p.E847E	Substitution - coding silent	Endometrium
COSM1161462	c.1545G>C	p.L515F	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3594792	c.3189C>T	p.P1063P	Substitution - coding silent	Skin
COSM1045660	c.1805G>A	p.R602H	Substitution - Missense	Stomach

> Text Mining based Variations

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PMID	Variation	Cancer	Evidence
22139574	loss of expression (mutation)	Ovarian Carcinoma	The SKOV3 cell line possesses a heterozygous 4bp deletion that results in an 855AA truncated protein, while the cause of the loss of BAF155 expression in the SNUC2B cell line appears due to a post-transcriptional error.
24916674	mutation	Malignant Mesothelioma	In one patient, homozygous germline variants were observed for SMARCC1 and SETD2 in chr3p22.1-3p14.2.
26812616	mutation	Esophageal Squamous Cell Carcinoma	Deep sequencing of components of the SWI/SNF complex using a bench-top next generation sequencer revealed that eight of 92 ESCCs (8.7%) had 11 somatic mutations of 7 genes, ARID1A, ARID2, ATRX, PBRM1, SMARCA4, SMARCAL1, and SMARCC1.
27834213	mutation (loss of function)	Malignant Mesothelioma	Combined high-density aCGH and tNGS revealed biallelic gene inactivation in SETD2 (9 of 33, 27%), BAP1 (16 of 33, 48%), PBRM1 (5 of 33, 15%), and SMARCC1 (2 of 33, 6%).

Summary
Symbol	SMARCC1
Name	SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1
Aliases	BAF155; SRG3; CRACC1; SWI3; BRG1-associated factor 155; SWI/SNF complex 155 kDa subunit; SWI/SNF-related mat ......
Location	3p21.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

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Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
Q92922	310	S	Phosphoserine	-	No	None detected
Q92922	328	S	Phosphoserine	-	No	None detected
Q92922	330	S	Phosphoserine	-	No	None detected
Q92922	335	T	Phosphothreonine	-	Yes	p.T335A (cancer: STAD)
Q92922	345	K	N6-acetyllysine	-	No	None detected
Q92922	346	K	N6-acetyllysine	-	No	None detected
Q92922	350	S	Phosphoserine	-	No	None detected
Q92922	354	K	N6-acetyllysine	-	No	None detected
Q92922	357	S	Phosphoserine	-	No	None detected
Q92922	359	K	N6-acetyllysine	-	No	None detected
Q92922	398	T	Phosphothreonine	-	No	None detected
Q92922	573	S	Phosphoserine	-	No	None detected
Q92922	822	S	Phosphoserine	-	No	None detected
Q92922	825	S	Phosphoserine	-	No	None detected
Q92922	948	K	N6-acetyllysine	-	No	None detected
Q92922	1064	R	Asymmetric dimethylarginine	-	No	None detected

Summary
Symbol	SMARCC1
Name	SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1
Aliases	BAF155; SRG3; CRACC1; SWI3; BRG1-associated factor 155; SWI/SNF complex 155 kDa subunit; SWI/SNF-related mat ......
Location	3p21.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

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Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	7.069	7.302	0.094	0.625	NS
BRCA	Breast invasive carcinoma	112	1100	7.142	7.534	0.457	4.51e-14	NS
CESC	Cervical and endocervical cancers	3	306	6.21	6.996	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	6.856	7.615	0.736	2.45e-23	Over
ESCA	Esophageal carcinoma	11	185	6.954	7.14	0.176	0.377	NS
GBM	Glioblastoma multiforme	5	166	5.027	6.363	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	6.878	6.694	-0.12	0.218	NS
KIRC	Kidney renal clear cell carcinoma	72	534	7.034	6.145	-0.898	4.63e-49	Under
KIRP	Kidney renal papillary cell carcinoma	32	291	6.85	6.56	-0.279	0.00587	NS
LAML	Acute Myeloid Leukemia	0	173	NA	8.046	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	6.499	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	5.304	5.683	0.452	9.05e-08	NS
LUAD	Lung adenocarcinoma	59	517	6.511	6.963	0.46	1.17e-09	NS
LUSC	Lung squamous cell carcinoma	51	501	6.474	7.017	0.564	5.28e-11	NS
OV	Ovarian serous cystadenocarcinoma	0	307	NA	7.521	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	6.826	6.608	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	5.394	5.3	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	7.167	7.499	0.323	5.13e-06	NS
READ	Rectum adenocarcinoma	10	167	7.018	7.739	0.65	0.000133	Over
SARC	Sarcoma	2	263	6.677	6.551	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	7.359	7.308	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	6.55	7.139	0.571	6.11e-09	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	7.671	NA	NA	NA
THCA	Thyroid carcinoma	59	509	6.762	6.769	0.033	0.555	NS
THYM	Thymoma	2	120	7.047	6.969	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	6.723	7.443	0.721	3.08e-12	Over

> Cancer Cell Line Encyclopedia (CCLE)

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Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	10
Autonomic ganglia	CHP212	9.8
Autonomic ganglia	IMR32	10.3
Autonomic ganglia	KELLY	10
Autonomic ganglia	KPNRTBM1	9.8
Autonomic ganglia	KPNSI9S	9
Autonomic ganglia	KPNYN	9.7
Autonomic ganglia	MHHNB11	10
Autonomic ganglia	NB1	10.7
Autonomic ganglia	NH6	9
Autonomic ganglia	SHSY5Y	9.8
Autonomic ganglia	SIMA	10.5
Autonomic ganglia	SKNAS	8.4
Autonomic ganglia	SKNBE2	9.1
Autonomic ganglia	SKNDZ	9.4
Autonomic ganglia	SKNFI	9.3
Autonomic ganglia	SKNSH	8.8
Biliary tract	HUCCT1	8.8
Biliary tract	HUH28	8.4
Biliary tract	SNU1079	8.8
Biliary tract	SNU1196	9.4
Biliary tract	SNU245	9.9
Biliary tract	SNU308	9.3
Biliary tract	SNU478	9.8
Bone	143B	9.2
Bone	A673	10.1
Bone	CADOES1	11.3
Bone	CAL78	8.5
Bone	G292CLONEA141B1	8.8
Bone	HOS	9.1
Bone	HS706T	7.8
Bone	HS737T	7.8
Bone	HS819T	7.4
Bone	HS821T	8.2
Bone	HS822T	7.4
Bone	HS863T	8.3
Bone	HS870T	7.6
Bone	HS888T	8.7
Bone	MG63	8.4
Bone	MHHES1	10.1
Bone	OUMS27	8.3
Bone	RDES	10.1
Bone	SJSA1	8.3
Bone	SKES1	9.9
Bone	SKNMC	9.8
Bone	SW1353	8.6
Bone	T173	7.6
Bone	TC71	10
Bone	U2OS	9.1
Breast	AU565	8.8
Breast	BT20	8.7
Breast	BT474	9.3
Breast	BT483	9.8
Breast	BT549	9.5
Breast	CAL120	10.1
Breast	CAL148	10.5
Breast	CAL51	10.3
Breast	CAL851	8.5
Breast	CAMA1	8.4
Breast	DU4475	9
Breast	EFM192A	8.7
Breast	EFM19	9.6
Breast	EVSAT	9.4
Breast	HCC1143	8.6
Breast	HCC1187	9.5
Breast	HCC1395	9.1
Breast	HCC1419	9.1
Breast	HCC1428	8.7
Breast	HCC1500	8.6
Breast	HCC1569	8.3
Breast	HCC1599	9.5
Breast	HCC1806	8.1
Breast	HCC1937	8.8
Breast	HCC1954	9
Breast	HCC202	8.6
Breast	HCC2157	9.3
Breast	HCC2218	8.5
Breast	HCC38	8.5
Breast	HCC70	8.6
Breast	HDQP1	8.9
Breast	HMC18	8.6
Breast	HS274T	8.1
Breast	HS281T	8.5
Breast	HS343T	8.6
Breast	HS578T	8.5
Breast	HS606T	8
Breast	HS739T	8
Breast	HS742T	8
Breast	JIMT1	9.6
Breast	KPL1	8.6
Breast	MCF7	7.9
Breast	MDAMB134VI	9.4
Breast	MDAMB157	7.9
Breast	MDAMB175VII	8.4
Breast	MDAMB231	8.4
Breast	MDAMB361	8.9
Breast	MDAMB415	7.3
Breast	MDAMB436	8.7
Breast	MDAMB453	8.9
Breast	MDAMB468	8.7
Breast	SKBR3	8.8
Breast	T47D	8.3
Breast	UACC812	9.1
Breast	UACC893	5.2
Breast	YMB1	8.4
Breast	ZR751	7.9
Breast	ZR7530	9.8
Central nervous system	1321N1	9.2
Central nervous system	42MGBA	9
Central nervous system	8MGBA	8.6
Central nervous system	A172	8.3
Central nervous system	AM38	8.4
Central nervous system	BECKER	7.9
Central nervous system	CAS1	8.4
Central nervous system	CCFSTTG1	6.9
Central nervous system	D283MED	9.7
Central nervous system	D341MED	9
Central nervous system	DAOY	8.9
Central nervous system	DBTRG05MG	7.8
Central nervous system	DKMG	8.4
Central nervous system	GAMG	8.2
Central nervous system	GB1	9.6
Central nervous system	GI1	9.4
Central nervous system	GMS10	8.8
Central nervous system	GOS3	8.2
Central nervous system	H4	7.8
Central nervous system	HS683	7.8
Central nervous system	KALS1	9
Central nervous system	KG1C	7.6
Central nervous system	KNS42	8.5
Central nervous system	KNS60	8.7
Central nervous system	KNS81	8.7
Central nervous system	KS1	8.3
Central nervous system	LN18	9.2
Central nervous system	LN229	8.4
Central nervous system	M059K	8.1
Central nervous system	MOGGCCM	8.7
Central nervous system	MOGGUVW	8.7
Central nervous system	NMCG1	7.7
Central nervous system	ONS76	8.6
Central nervous system	SF126	8.3
Central nervous system	SF295	8.4
Central nervous system	SNB19	8.7
Central nervous system	SNU1105	8.9
Central nervous system	SNU201	8.7
Central nervous system	SNU466	8.6
Central nervous system	SNU489	9.3
Central nervous system	SNU626	7.5
Central nervous system	SNU738	9.5
Central nervous system	SW1088	8.4
Central nervous system	SW1783	8.1
Central nervous system	T98G	9.1
Central nervous system	TM31	9.1
Central nervous system	U118MG	8.6
Central nervous system	U138MG	8.4
Central nervous system	U251MG	8.3
Central nervous system	U87MG	7.6
Central nervous system	YH13	8.8
Central nervous system	YKG1	8.6
Endometrium	AN3CA	9.1
Endometrium	COLO684	9.5
Endometrium	EFE184	8.9
Endometrium	EN	8.6
Endometrium	ESS1	8.7
Endometrium	HEC108	8.7
Endometrium	HEC151	8.8
Endometrium	HEC1A	9.6
Endometrium	HEC1B	10.1
Endometrium	HEC251	9.3
Endometrium	HEC265	8.9
Endometrium	HEC50B	8.5
Endometrium	HEC59	9.4
Endometrium	HEC6	8.7
Endometrium	ISHIKAWAHERAKLIO02ER	8.5
Endometrium	JHUEM1	9.2
Endometrium	JHUEM2	10
Endometrium	JHUEM3	8.9
Endometrium	KLE	8.2
Endometrium	MFE280	8.5
Endometrium	MFE296	9.2
Endometrium	MFE319	8.3
Endometrium	RL952	8.9
Endometrium	SNGM	9.5
Endometrium	SNU1077	9.2
Endometrium	SNU685	9.9
Endometrium	TEN	8.5
Haematopoietic and lymphoid	697	10.6
Haematopoietic and lymphoid	A3KAW	8.7
Haematopoietic and lymphoid	A4FUK	9.3
Haematopoietic and lymphoid	ALLSIL	10.3
Haematopoietic and lymphoid	AML193	9.7
Haematopoietic and lymphoid	AMO1	10
Haematopoietic and lymphoid	BCP1	9.1
Haematopoietic and lymphoid	BDCM	9.3
Haematopoietic and lymphoid	BL41	10.2
Haematopoietic and lymphoid	BL70	10
Haematopoietic and lymphoid	BV173	10.2
Haematopoietic and lymphoid	CA46	9.1
Haematopoietic and lymphoid	CI1	9.6
Haematopoietic and lymphoid	CMK115	10
Haematopoietic and lymphoid	CMK86	10.3
Haematopoietic and lymphoid	CMK	10.3
Haematopoietic and lymphoid	CMLT1	9.7
Haematopoietic and lymphoid	COLO775	10.1
Haematopoietic and lymphoid	DAUDI	9.2
Haematopoietic and lymphoid	DB	8.4
Haematopoietic and lymphoid	DEL	8.9
Haematopoietic and lymphoid	DND41	9.9
Haematopoietic and lymphoid	DOHH2	10
Haematopoietic and lymphoid	EB1	9.3
Haematopoietic and lymphoid	EB2	9.4
Haematopoietic and lymphoid	EHEB	9.4
Haematopoietic and lymphoid	EJM	8.9
Haematopoietic and lymphoid	EM2	10.2
Haematopoietic and lymphoid	EOL1	9.9
Haematopoietic and lymphoid	F36P	9.1
Haematopoietic and lymphoid	GA10	10
Haematopoietic and lymphoid	GDM1	9
Haematopoietic and lymphoid	GRANTA519	9.3
Haematopoietic and lymphoid	HDLM2	9.1
Haematopoietic and lymphoid	HDMYZ	8.8
Haematopoietic and lymphoid	HEL9217	9.9
Haematopoietic and lymphoid	HEL	10.1
Haematopoietic and lymphoid	HH	9.7
Haematopoietic and lymphoid	HL60	9.8
Haematopoietic and lymphoid	HPBALL	9.2
Haematopoietic and lymphoid	HS604T	7.8
Haematopoietic and lymphoid	HS611T	9
Haematopoietic and lymphoid	HS616T	7.9
Haematopoietic and lymphoid	HS751T	7.6
Haematopoietic and lymphoid	HT	9.9
Haematopoietic and lymphoid	HTK	9.8
Haematopoietic and lymphoid	HUNS1	9.2
Haematopoietic and lymphoid	HUT102	8.6
Haematopoietic and lymphoid	HUT78	9.2
Haematopoietic and lymphoid	JEKO1	10.4
Haematopoietic and lymphoid	JK1	9.5
Haematopoietic and lymphoid	JM1	10.1
Haematopoietic and lymphoid	JURKAT	10.1
Haematopoietic and lymphoid	JURLMK1	9.6
Haematopoietic and lymphoid	JVM2	8.9
Haematopoietic and lymphoid	JVM3	9.8
Haematopoietic and lymphoid	K562	9.5
Haematopoietic and lymphoid	KARPAS299	8.8
Haematopoietic and lymphoid	KARPAS422	9.5
Haematopoietic and lymphoid	KARPAS620	10.3
Haematopoietic and lymphoid	KASUMI1	9.8
Haematopoietic and lymphoid	KASUMI2	9.8
Haematopoietic and lymphoid	KASUMI6	9.5
Haematopoietic and lymphoid	KCL22	9.6
Haematopoietic and lymphoid	KE37	9.4
Haematopoietic and lymphoid	KE97	9.1
Haematopoietic and lymphoid	KG1	9.2
Haematopoietic and lymphoid	KHM1B	8.9
Haematopoietic and lymphoid	KIJK	9.2
Haematopoietic and lymphoid	KMH2	9.8
Haematopoietic and lymphoid	KMM1	9
Haematopoietic and lymphoid	KMS11	8.4
Haematopoietic and lymphoid	KMS12BM	10.4
Haematopoietic and lymphoid	KMS18	9.6
Haematopoietic and lymphoid	KMS20	9.7
Haematopoietic and lymphoid	KMS21BM	8.8
Haematopoietic and lymphoid	KMS26	8.5
Haematopoietic and lymphoid	KMS27	8.9
Haematopoietic and lymphoid	KMS28BM	8.4
Haematopoietic and lymphoid	KMS34	9.2
Haematopoietic and lymphoid	KO52	9.4
Haematopoietic and lymphoid	KOPN8	10.2
Haematopoietic and lymphoid	KU812	10.1
Haematopoietic and lymphoid	KYO1	10.1
Haematopoietic and lymphoid	L1236	8.8
Haematopoietic and lymphoid	L363	9
Haematopoietic and lymphoid	L428	9.5
Haematopoietic and lymphoid	L540	9.1
Haematopoietic and lymphoid	LAMA84	9.7
Haematopoietic and lymphoid	LOUCY	9.6
Haematopoietic and lymphoid	LP1	8.6
Haematopoietic and lymphoid	M07E	10.8
Haematopoietic and lymphoid	MC116	9.7
Haematopoietic and lymphoid	ME1	10.3
Haematopoietic and lymphoid	MEC1	10.1
Haematopoietic and lymphoid	MEC2	9.8
Haematopoietic and lymphoid	MEG01	9.4
Haematopoietic and lymphoid	MHHCALL2	10.1
Haematopoietic and lymphoid	MHHCALL3	9.8
Haematopoietic and lymphoid	MHHCALL4	10.1
Haematopoietic and lymphoid	MINO	10.3
Haematopoietic and lymphoid	MJ	9.6
Haematopoietic and lymphoid	MM1S	9.3
Haematopoietic and lymphoid	MOLM13	9.4
Haematopoietic and lymphoid	MOLM16	10.1
Haematopoietic and lymphoid	MOLM6	9.7
Haematopoietic and lymphoid	MOLP2	9.7
Haematopoietic and lymphoid	MOLP8	9.2
Haematopoietic and lymphoid	MOLT13	10.5
Haematopoietic and lymphoid	MOLT16	9.9
Haematopoietic and lymphoid	MOLT4	9.7
Haematopoietic and lymphoid	MONOMAC1	9.2
Haematopoietic and lymphoid	MONOMAC6	9.7
Haematopoietic and lymphoid	MOTN1	9.4
Haematopoietic and lymphoid	MUTZ5	9.9
Haematopoietic and lymphoid	MV411	9.8
Haematopoietic and lymphoid	NALM19	10
Haematopoietic and lymphoid	NALM1	9.9
Haematopoietic and lymphoid	NALM6	10
Haematopoietic and lymphoid	NAMALWA	9.3
Haematopoietic and lymphoid	NB4	10
Haematopoietic and lymphoid	NCIH929	8.2
Haematopoietic and lymphoid	NCO2	9.5
Haematopoietic and lymphoid	NOMO1	9.7
Haematopoietic and lymphoid	NUDHL1	9.7
Haematopoietic and lymphoid	NUDUL1	10.7
Haematopoietic and lymphoid	OCIAML2	9.5
Haematopoietic and lymphoid	OCIAML3	9.4
Haematopoietic and lymphoid	OCIAML5	9.6
Haematopoietic and lymphoid	OCILY10	9.5
Haematopoietic and lymphoid	OCILY19	10.2
Haematopoietic and lymphoid	OCILY3	9.8
Haematopoietic and lymphoid	OCIM1	10
Haematopoietic and lymphoid	OPM2	8.6
Haematopoietic and lymphoid	P12ICHIKAWA	10.4
Haematopoietic and lymphoid	P31FUJ	8.6
Haematopoietic and lymphoid	P3HR1	9.3
Haematopoietic and lymphoid	PCM6	8.5
Haematopoietic and lymphoid	PEER	9.9
Haematopoietic and lymphoid	PF382	9.6
Haematopoietic and lymphoid	PFEIFFER	10.9
Haematopoietic and lymphoid	PL21	9.6
Haematopoietic and lymphoid	RAJI	9.5
Haematopoietic and lymphoid	RCHACV	10.5
Haematopoietic and lymphoid	REC1	10.1
Haematopoietic and lymphoid	REH	8.7
Haematopoietic and lymphoid	RI1	10.3
Haematopoietic and lymphoid	RL	9.5
Haematopoietic and lymphoid	RPMI8226	9.5
Haematopoietic and lymphoid	RPMI8402	10.8
Haematopoietic and lymphoid	RS411	9.7
Haematopoietic and lymphoid	SEM	10
Haematopoietic and lymphoid	SET2	9.8
Haematopoietic and lymphoid	SIGM5	10.2
Haematopoietic and lymphoid	SKM1	9.1
Haematopoietic and lymphoid	SKMM2	9.6
Haematopoietic and lymphoid	SR786	9.2
Haematopoietic and lymphoid	ST486	9.3
Haematopoietic and lymphoid	SUDHL10	10.1
Haematopoietic and lymphoid	SUDHL1	9.8
Haematopoietic and lymphoid	SUDHL4	9.6
Haematopoietic and lymphoid	SUDHL5	10.2
Haematopoietic and lymphoid	SUDHL6	10.3
Haematopoietic and lymphoid	SUDHL8	10.1
Haematopoietic and lymphoid	SUPB15	9.6
Haematopoietic and lymphoid	SUPHD1	9.6
Haematopoietic and lymphoid	SUPM2	8.2
Haematopoietic and lymphoid	SUPT11	9.7
Haematopoietic and lymphoid	SUPT1	9.6
Haematopoietic and lymphoid	TALL1	9.7
Haematopoietic and lymphoid	TF1	9.7
Haematopoietic and lymphoid	THP1	8.9
Haematopoietic and lymphoid	TO175T	7.8
Haematopoietic and lymphoid	TOLEDO	9.5
Haematopoietic and lymphoid	U266B1	8.7
Haematopoietic and lymphoid	U937	9.5
Haematopoietic and lymphoid	UT7	8.9
Haematopoietic and lymphoid	WSUDLCL2	9.8
Kidney	769P	8.2
Kidney	786O	9
Kidney	A498	8
Kidney	A704	6.4
Kidney	ACHN	8.3
Kidney	BFTC909	9.2
Kidney	CAKI1	7.9
Kidney	CAKI2	8.1
Kidney	CAL54	9.1
Kidney	KMRC1	7.5
Kidney	KMRC20	7.5
Kidney	KMRC2	8
Kidney	KMRC3	7
Kidney	OSRC2	7.8
Kidney	RCC10RGB	7.9
Kidney	SNU1272	8.1
Kidney	SNU349	7.4
Kidney	TUHR10TKB	8.3
Kidney	TUHR14TKB	8.2
Kidney	TUHR4TKB	7.6
Kidney	VMRCRCW	8.2
Kidney	VMRCRCZ	8
Large intestine	C2BBE1	8.9
Large intestine	CCK81	9.8
Large intestine	CL11	9.6
Large intestine	CL14	9.1
Large intestine	CL34	9.5
Large intestine	CL40	9.4
Large intestine	COLO205	8.4
Large intestine	COLO320	9.8
Large intestine	COLO678	9.4
Large intestine	CW2	9.9
Large intestine	DLD1	9
Large intestine	GP2D	9.2
Large intestine	HCC56	9.2
Large intestine	HCT116	9.5
Large intestine	HCT15	9.5
Large intestine	HS675T	7.2
Large intestine	HS698T	8.2
Large intestine	HT115	9.4
Large intestine	HT29	8.8
Large intestine	HT55	9.1
Large intestine	KM12	8.7
Large intestine	LOVO	9.1
Large intestine	LS1034	9.4
Large intestine	LS123	9.3
Large intestine	LS180	9.2
Large intestine	LS411N	8.8
Large intestine	LS513	8.9
Large intestine	MDST8	8.3
Large intestine	NCIH508	9.1
Large intestine	NCIH716	8.3
Large intestine	NCIH747	8.5
Large intestine	OUMS23	8.9
Large intestine	RCM1	8.5
Large intestine	RKO	8.2
Large intestine	SKCO1	9.3
Large intestine	SNU1040	8.8
Large intestine	SNU1197	7.8
Large intestine	SNU175	9.2
Large intestine	SNU283	10.1
Large intestine	SNU407	10
Large intestine	SNU503	9.1
Large intestine	SNU61	8.9
Large intestine	SNU81	9
Large intestine	SNUC1	9.3
Large intestine	SNUC2A	5.5
Large intestine	SNUC4	9.6
Large intestine	SNUC5	9.2
Large intestine	SW1116	8.7
Large intestine	SW1417	9.6
Large intestine	SW1463	9.6
Large intestine	SW403	8.4
Large intestine	SW480	8.7
Large intestine	SW48	9.4
Large intestine	SW620	9.8
Large intestine	SW837	8
Large intestine	SW948	9.1
Large intestine	T84	9.1
Liver	ALEXANDERCELLS	8.6
Liver	C3A	8.7
Liver	HEP3B217	9.5
Liver	HEPG2	8.9
Liver	HLE	8.9
Liver	HLF	7.9
Liver	HUH1	9
Liver	HUH6	8.6
Liver	HUH7	9.4
Liver	JHH1	8.8
Liver	JHH2	8.2
Liver	JHH4	9.2
Liver	JHH5	9.3
Liver	JHH6	8.5
Liver	JHH7	9.1
Liver	LI7	8.5
Liver	PLCPRF5	8.1
Liver	SKHEP1	8.4
Liver	SNU182	8.8
Liver	SNU387	7.8
Liver	SNU398	9.4
Liver	SNU423	8.9
Liver	SNU449	8.9
Liver	SNU475	8.5
Liver	SNU761	8.9
Liver	SNU878	8.7
Liver	SNU886	9.4
Lung	A549	8
Lung	ABC1	8.8
Lung	BEN	8.5
Lung	CAL12T	8.2
Lung	CALU1	8
Lung	CALU3	9.4
Lung	CALU6	9.1
Lung	CHAGOK1	7.6
Lung	COLO668	9.6
Lung	COLO699	9.2
Lung	CORL105	8
Lung	CORL23	9
Lung	CORL24	8.6
Lung	CORL279	9.1
Lung	CORL311	9.2
Lung	CORL47	8.4
Lung	CORL51	8.4
Lung	CORL88	9.4
Lung	CORL95	8.7
Lung	CPCN	8
Lung	DMS114	9.4
Lung	DMS153	8.6
Lung	DMS273	9.4
Lung	DMS454	7.1
Lung	DMS53	7.5
Lung	DMS79	8.7
Lung	DV90	8.5
Lung	EBC1	8.2
Lung	EPLC272H	8.1
Lung	HARA	9
Lung	HCC1171	8.7
Lung	HCC1195	8.7
Lung	HCC15	8.3
Lung	HCC2279	8.2
Lung	HCC2935	7.9
Lung	HCC33	9.8
Lung	HCC366	7.9
Lung	HCC4006	8.6
Lung	HCC44	9.2
Lung	HCC78	8.7
Lung	HCC827	9.3
Lung	HCC95	8.4
Lung	HLC1	8.9
Lung	HLFA	7.7
Lung	HS229T	8.2
Lung	HS618T	7.9
Lung	IALM	9.3
Lung	KNS62	8.6
Lung	LC1F	8.5
Lung	LC1SQSF	7.5
Lung	LCLC103H	9.5
Lung	LCLC97TM1	10
Lung	LK2	10.1
Lung	LOUNH91	8.6
Lung	LU65	8.7
Lung	LU99	9.2
Lung	LUDLU1	7.9
Lung	LXF289	9.4
Lung	MORCPR	9.1
Lung	NCIH1048	9.2
Lung	NCIH1092	8.8
Lung	NCIH1105	9.2
Lung	NCIH1155	9
Lung	NCIH1184	9.3
Lung	NCIH1299	8.9
Lung	NCIH1339	8.9
Lung	NCIH1341	9
Lung	NCIH1355	8.2
Lung	NCIH1373	7.4
Lung	NCIH1385	7.9
Lung	NCIH1395	7.9
Lung	NCIH1435	8.7
Lung	NCIH1436	8.4
Lung	NCIH1437	8.3
Lung	NCIH146	9.3
Lung	NCIH1563	7.9
Lung	NCIH1568	9.1
Lung	NCIH1573	7.4
Lung	NCIH1581	9.5
Lung	NCIH1618	8.8
Lung	NCIH1623	8.3
Lung	NCIH1648	8.6
Lung	NCIH1650	8.8
Lung	NCIH1651	7.9
Lung	NCIH1666	8.5
Lung	NCIH1693	7.8
Lung	NCIH1694	8
Lung	NCIH1703	9.4
Lung	NCIH1734	8.5
Lung	NCIH1755	8.3
Lung	NCIH1781	8.8
Lung	NCIH1792	8.6
Lung	NCIH1793	8.5
Lung	NCIH1836	8.7
Lung	NCIH1838	8.1
Lung	NCIH1869	9.7
Lung	NCIH1876	9.5
Lung	NCIH1915	8.4
Lung	NCIH1930	9
Lung	NCIH1944	8.4
Lung	NCIH1963	9
Lung	NCIH196	8.3
Lung	NCIH1975	8.6
Lung	NCIH2009	9
Lung	NCIH2023	7.8
Lung	NCIH2029	10
Lung	NCIH2030	8.7
Lung	NCIH2066	7.6
Lung	NCIH2081	7.6
Lung	NCIH2085	8.5
Lung	NCIH2087	8.6
Lung	NCIH209	9
Lung	NCIH2106	9.4
Lung	NCIH2110	8.4
Lung	NCIH211	9.1
Lung	NCIH2122	8.5
Lung	NCIH2126	8.3
Lung	NCIH2141	9.7
Lung	NCIH2170	9.1
Lung	NCIH2171	8.9
Lung	NCIH2172	7.1
Lung	NCIH2196	7.5
Lung	NCIH2227	9.1
Lung	NCIH2228	7.8
Lung	NCIH226	8.3
Lung	NCIH2286	8.2
Lung	NCIH2291	8.5
Lung	NCIH2342	8.8
Lung	NCIH2347	8.7
Lung	NCIH23	8.6
Lung	NCIH2405	7.9
Lung	NCIH2444	7.7
Lung	NCIH292	8.7
Lung	NCIH322	8.2
Lung	NCIH3255	7.9
Lung	NCIH358	9.2
Lung	NCIH441	8.7
Lung	NCIH446	8.8
Lung	NCIH460	8.4
Lung	NCIH510	8.9
Lung	NCIH520	9
Lung	NCIH522	9.3
Lung	NCIH524	9.5
Lung	NCIH526	10.2
Lung	NCIH596	7.8
Lung	NCIH647	8.3
Lung	NCIH650	9
Lung	NCIH661	8.1
Lung	NCIH69	8.8
Lung	NCIH727	9.3
Lung	NCIH810	8.3
Lung	NCIH82	9.5
Lung	NCIH838	9.1
Lung	NCIH841	9.5
Lung	NCIH854	9.1
Lung	NCIH889	9.3
Lung	PC14	8.9
Lung	RERFLCAD1	8.1
Lung	RERFLCAD2	7.9
Lung	RERFLCAI	8.6
Lung	RERFLCKJ	7.8
Lung	RERFLCMS	8
Lung	RERFLCSQ1	8.1
Lung	SBC5	9
Lung	SCLC21H	9.5
Lung	SHP77	10.2
Lung	SKLU1	8
Lung	SKMES1	5.6
Lung	SQ1	9
Lung	SW1271	8.4
Lung	SW1573	8.5
Lung	SW900	7.8
Lung	VMRCLCD	8.9
Lung	VMRCLCP	8.8
Oesophagus	COLO680N	8.3
Oesophagus	ECGI10	8.3
Oesophagus	KYSE140	8.9
Oesophagus	KYSE150	8.9
Oesophagus	KYSE180	9
Oesophagus	KYSE270	8.6
Oesophagus	KYSE30	8.3
Oesophagus	KYSE410	9.1
Oesophagus	KYSE450	8.5
Oesophagus	KYSE510	9.2
Oesophagus	KYSE520	8.3
Oesophagus	KYSE70	8.8
Oesophagus	OE19	8.6
Oesophagus	OE33	8.8
Oesophagus	TE10	8.6
Oesophagus	TE11	8.6
Oesophagus	TE14	8.4
Oesophagus	TE15	8.2
Oesophagus	TE1	8.3
Oesophagus	TE4	9.4
Oesophagus	TE5	8.3
Oesophagus	TE6	9.2
Oesophagus	TE8	8.9
Oesophagus	TE9	8.3
Oesophagus	TT	8
Ovary	59M	9.2
Ovary	A2780	9.6
Ovary	CAOV3	7.8
Ovary	CAOV4	8.5
Ovary	COLO704	9.6
Ovary	COV318	8.7
Ovary	COV362	8.4
Ovary	COV434	8.7
Ovary	COV504	7.7
Ovary	COV644	8.4
Ovary	EFO21	8.6
Ovary	EFO27	8.8
Ovary	ES2	8.9
Ovary	FUOV1	8.9
Ovary	HEYA8	8.9
Ovary	HS571T	7.3
Ovary	IGROV1	9.2
Ovary	JHOC5	8.8
Ovary	JHOM1	8.9
Ovary	JHOM2B	9.7
Ovary	JHOS2	8.1
Ovary	JHOS4	8.3
Ovary	KURAMOCHI	9.3
Ovary	MCAS	8.6
Ovary	NIHOVCAR3	9.3
Ovary	OAW28	9.5
Ovary	OAW42	8.6
Ovary	OC314	8.7
Ovary	OC316	8.6
Ovary	ONCODG1	9.9
Ovary	OV56	7.8
Ovary	OV7	8.8
Ovary	OV90	8.3
Ovary	OVCAR4	9
Ovary	OVCAR8	9.2
Ovary	OVISE	8.4
Ovary	OVK18	9.3
Ovary	OVKATE	7.2
Ovary	OVMANA	7.9
Ovary	OVSAHO	8.8
Ovary	OVTOKO	8.1
Ovary	RMGI	8.6
Ovary	RMUGS	7.7
Ovary	SKOV3	4.9
Ovary	SNU119	9.4
Ovary	SNU840	9.4
Ovary	SNU8	9.2
Ovary	TOV112D	9.3
Ovary	TOV21G	8.8
Ovary	TYKNU	8.9
Pancreas	ASPC1	8.6
Pancreas	BXPC3	8.6
Pancreas	CAPAN1	9.9
Pancreas	CAPAN2	8.8
Pancreas	CFPAC1	7.7
Pancreas	DANG	8.5
Pancreas	HPAC	9.1
Pancreas	HPAFII	8.6
Pancreas	HS766T	8.1
Pancreas	HUPT3	8.7
Pancreas	HUPT4	8.9
Pancreas	KCIMOH1	9.5
Pancreas	KLM1	9.5
Pancreas	KP2	8.9
Pancreas	KP3	7.9
Pancreas	KP4	8.6
Pancreas	L33	8.3
Pancreas	MIAPACA2	9.7
Pancreas	PANC0203	7.7
Pancreas	PANC0213	8.5
Pancreas	PANC0327	8.8
Pancreas	PANC0403	8.1
Pancreas	PANC0504	8.3
Pancreas	PANC0813	8.9
Pancreas	PANC1005	8.5
Pancreas	PANC1	8.1
Pancreas	PATU8902	8.1
Pancreas	PATU8988S	8.6
Pancreas	PATU8988T	9.4
Pancreas	PK1	8.2
Pancreas	PK45H	9
Pancreas	PK59	8.8
Pancreas	PL45	7.9
Pancreas	PSN1	9.7
Pancreas	QGP1	9.1
Pancreas	SNU213	9.2
Pancreas	SNU324	9.3
Pancreas	SNU410	8.3
Pancreas	SU8686	7.6
Pancreas	SUIT2	8.8
Pancreas	SW1990	8.1
Pancreas	T3M4	8.2
Pancreas	TCCPAN2	7.3
Pancreas	YAPC	8.8
Pleura	ACCMESO1	8.2
Pleura	DM3	8.6
Pleura	ISTMES1	8
Pleura	ISTMES2	7.6
Pleura	JL1	9.7
Pleura	MPP89	8.5
Pleura	MSTO211H	8.6
Pleura	NCIH2052	7.9
Pleura	NCIH2452	7.9
Pleura	NCIH28	9.4
Prostate	22RV1	9
Prostate	DU145	8.4
Prostate	LNCAPCLONEFGC	8.2
Prostate	MDAPCA2B	9.5
Prostate	NCIH660	9.3
Prostate	PC3	8.7
Prostate	VCAP	9.2
Salivary gland	A253	8.2
Salivary gland	YD15	8.7
Skin	A101D	7.9
Skin	A2058	9.5
Skin	A375	9.6
Skin	C32	8.5
Skin	CHL1	9.3
Skin	CJM	8.7
Skin	COLO679	8.6
Skin	COLO741	9
Skin	COLO783	8.7
Skin	COLO792	8.2
Skin	COLO800	8.5
Skin	COLO818	7.4
Skin	COLO829	9.2
Skin	COLO849	9.5
Skin	G361	9.4
Skin	GRM	9.1
Skin	HMCB	9.6
Skin	HS294T	8.5
Skin	HS600T	7.5
Skin	HS688AT	7.7
Skin	HS695T	8.1
Skin	HS839T	7.7
Skin	HS852T	8.7
Skin	HS895T	7.7
Skin	HS934T	8.3
Skin	HS936T	8.1
Skin	HS939T	8.1
Skin	HS940T	8
Skin	HS944T	9.2
Skin	HT144	8.8
Skin	IGR1	8.5
Skin	IGR37	8.8
Skin	IGR39	8.8
Skin	IPC298	8.8
Skin	K029AX	8.9
Skin	LOXIMVI	9
Skin	MALME3M	8.5
Skin	MDAMB435S	7.9
Skin	MELHO	8.8
Skin	MELJUSO	8.9
Skin	MEWO	8.8
Skin	RPMI7951	8.5
Skin	RVH421	8.4
Skin	SH4	8.9
Skin	SKMEL1	8.3
Skin	SKMEL24	7.6
Skin	SKMEL28	8.7
Skin	SKMEL2	9.2
Skin	SKMEL30	9.1
Skin	SKMEL31	8.2
Skin	SKMEL3	8.6
Skin	SKMEL5	8.5
Skin	UACC257	8.2
Skin	UACC62	8.7
Skin	WM115	8.5
Skin	WM1799	8.7
Skin	WM2664	9.1
Skin	WM793	8.2
Skin	WM88	8.7
Skin	WM983B	7.8
Small intestine	HUTU80	9.3
Soft tissue	A204	8.6
Soft tissue	G401	9.3
Soft tissue	G402	9.2
Soft tissue	GCT	9
Soft tissue	HS729	8.3
Soft tissue	HT1080	9
Soft tissue	KYM1	9
Soft tissue	MESSA	9.4
Soft tissue	RD	9.7
Soft tissue	RH30	9.6
Soft tissue	RH41	9.3
Soft tissue	RKN	8.2
Soft tissue	S117	8.9
Soft tissue	SJRH30	9.5
Soft tissue	SKLMS1	8
Soft tissue	SKUT1	9.2
Soft tissue	TE125T	8.1
Soft tissue	TE159T	7.3
Soft tissue	TE441T	9.5
Soft tissue	TE617T	8.8
Stomach	2313287	8.7
Stomach	AGS	9.2
Stomach	AZ521	10
Stomach	ECC10	10.3
Stomach	ECC12	9.1
Stomach	FU97	9
Stomach	GCIY	9.2
Stomach	GSS	8.6
Stomach	GSU	9.5
Stomach	HGC27	8.9
Stomach	HS746T	8.3
Stomach	HUG1N	8.9
Stomach	IM95	8.6
Stomach	KATOIII	8.4
Stomach	KE39	8.6
Stomach	LMSU	9.1
Stomach	MKN1	9.2
Stomach	MKN45	10.3
Stomach	MKN74	7
Stomach	MKN7	9.2
Stomach	NCCSTCK140	9.7
Stomach	NCIN87	8.5
Stomach	NUGC2	8.4
Stomach	NUGC3	8.8
Stomach	NUGC4	8.7
Stomach	OCUM1	9.4
Stomach	RERFGC1B	9
Stomach	SH10TC	8.4
Stomach	SNU16	9.5
Stomach	SNU1	8.4
Stomach	SNU216	9.9
Stomach	SNU520	9.3
Stomach	SNU5	8.9
Stomach	SNU601	9.9
Stomach	SNU620	9.1
Stomach	SNU668	8.4
Stomach	SNU719	9.3
Stomach	TGBC11TKB	9.6
Thyroid	8305C	9
Thyroid	8505C	9.7
Thyroid	BCPAP	9.2
Thyroid	BHT101	9.9
Thyroid	CAL62	9.2
Thyroid	CGTHW1	8.8
Thyroid	FTC133	8.4
Thyroid	FTC238	8.4
Thyroid	ML1	8.2
Thyroid	SW579	8.6
Thyroid	TT2609C02	9.3
Thyroid	TT	7.9
Upper aerodigestive tract	BHY	8.5
Upper aerodigestive tract	BICR16	8
Upper aerodigestive tract	BICR18	6.9
Upper aerodigestive tract	BICR22	7.8
Upper aerodigestive tract	BICR31	7.5
Upper aerodigestive tract	BICR56	7.9
Upper aerodigestive tract	BICR6	8.2
Upper aerodigestive tract	CAL27	7.9
Upper aerodigestive tract	CAL33	7.8
Upper aerodigestive tract	DETROIT562	8.2
Upper aerodigestive tract	FADU	8.6
Upper aerodigestive tract	HS840T	8.1
Upper aerodigestive tract	HSC2	8.5
Upper aerodigestive tract	HSC3	8.1
Upper aerodigestive tract	HSC4	8.6
Upper aerodigestive tract	PECAPJ15	7.9
Upper aerodigestive tract	PECAPJ34CLONEC12	8.2
Upper aerodigestive tract	PECAPJ41CLONED2	7.9
Upper aerodigestive tract	PECAPJ49	7.6
Upper aerodigestive tract	SCC15	8.2
Upper aerodigestive tract	SCC25	7.8
Upper aerodigestive tract	SCC4	8.2
Upper aerodigestive tract	SCC9	7.4
Upper aerodigestive tract	SNU1076	8.6
Upper aerodigestive tract	SNU1214	7.8
Upper aerodigestive tract	SNU46	8.7
Upper aerodigestive tract	SNU899	8.7
Upper aerodigestive tract	YD10B	8.2
Upper aerodigestive tract	YD38	8.8
Upper aerodigestive tract	YD8	9
Urinary tract	5637	8.9
Urinary tract	639V	10.5
Urinary tract	647V	10.1
Urinary tract	BC3C	8.6
Urinary tract	BFTC905	9.4
Urinary tract	CAL29	8.4
Urinary tract	HS172T	7.7
Urinary tract	HT1197	7.6
Urinary tract	HT1376	9.5
Urinary tract	J82	9
Urinary tract	JMSU1	10.1
Urinary tract	KMBC2	8.2
Urinary tract	KU1919	8.9
Urinary tract	RT11284	8.5
Urinary tract	RT112	8.2
Urinary tract	RT4	9.1
Urinary tract	SCABER	8.3
Urinary tract	SW1710	9.7
Urinary tract	SW780	8.1
Urinary tract	T24	8.5
Urinary tract	TCCSUP	8.6
Urinary tract	UMUC1	8.9
Urinary tract	UMUC3	8.4
Urinary tract	VMCUB1	8.9

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	12.3
Adrenal gland	9.4
Appendix	25.5
Bone marrow	13.3
Breast	28.6
Cerebral cortex	13.6
Cervix, uterine	29.2
Colon	18.9
Duodenum	15.1
Endometrium	30.2
Epididymis	18.6
Esophagus	17.2
Fallopian tube	20.9
Gallbladder	18.4
Heart muscle	6.4
Kidney	20.9
Liver	7.1
Lung	19.4
Lymph node	25.9
Ovary	21.6
Pancreas	3.3
Parathyroid gland	26.4
Placenta	31.3
Prostate	35.6
Rectum	24.5
Salivary gland	6
Seminal vesicle	23.5
Skeletal muscle	4.2
Skin	26.8
Small intestine	17.6
Smooth muscle	23.7
Spleen	22.6
Stomach	15.6
Testis	28.9
Thyroid gland	29.3
Tonsil	28.5
Urinary bladder	20.3

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
22139574	loss of expression (mutation)	Ovarian Carcinoma	The SKOV3 cell line possesses a heterozygous 4bp deletion that results in an 855AA truncated protein, while the cause of the loss of BAF155 expression in the SNUC2B cell line appears due to a post-transcriptional error.
21087120	overexpression	Prostate Carcinoma	The Smarcc1 protein, a part of the intranuclear SWI/SNF complex, is up-regulated in PC, and has been suggested to be implicated in tumour dedifferentiation, progression and biochemical recurrence.
18581278	overexpression	Prostate Carcinoma	All benign specimens showed no or minimal staining for SMARCC1. In 31% of the patients with recurrent disease and in 31% of the patients with metastatic disease we found moderate to strong SMARCC1 immunostaining.
27339451	loss of expression	Urothelial Carcinoma	SMARCA2 was most frequently lost (six) followed by ARID1A (four), SMARCB1/INI1 (two), SMARCA4 (one), and SMARCC1 (one).

Summary
Symbol	SMARCC1
Name	SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1
Aliases	BAF155; SRG3; CRACC1; SWI3; BRG1-associated factor 155; SWI/SNF complex 155 kDa subunit; SWI/SNF-related mat ......
Location	3p21.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.491	7.25e-26	28	46.8	25.2	Neutral
BRCA	Breast invasive carcinoma	1075	0.392	9.69e-41	31.6	59.9	8.5	Neutral
CESC	Cervical and endocervical cancers	292	0.695	2.18e-43	39.4	49.7	11	Loss
COAD	Colon adenocarcinoma	449	0.451	6.31e-24	15.4	76.2	8.5	Neutral
ESCA	Esophageal carcinoma	183	0.484	3.97e-12	64.5	28.4	7.1	Loss
GBM	Glioblastoma multiforme	147	0.35	1.41e-05	9.5	76.2	14.3	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.444	2.9e-26	71.8	26.3	1.9	Loss
KIRC	Kidney renal clear cell carcinoma	525	0.448	2.61e-27	88	10.9	1.1	Loss
KIRP	Kidney renal papillary cell carcinoma	288	0.444	2.45e-15	8.7	66.3	25	Neutral
LAML	Acute Myeloid Leukemia	166	0.3	8.72e-05	3.6	95.8	0.6	Neutral
LGG	Brain Lower Grade Glioma	513	0.26	2.36e-09	9.7	88.1	2.1	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.355	3e-12	17	72.5	10.4	Neutral
LUAD	Lung adenocarcinoma	512	0.304	1.97e-12	47.5	46.7	5.9	Loss
LUSC	Lung squamous cell carcinoma	498	0.062	0.165	86.1	13.1	0.8	Loss
OV	Ovarian serous cystadenocarcinoma	300	0.581	1.75e-28	34	46.3	19.7	Loss
PAAD	Pancreatic adenocarcinoma	177	0.42	5.79e-09	27.1	69.5	3.4	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.463	5.77e-10	37.7	61.1	1.2	Loss
PRAD	Prostate adenocarcinoma	491	0.292	3.86e-11	4.9	87.6	7.5	Neutral
READ	Rectum adenocarcinoma	164	0.576	7.07e-16	15.2	69.5	15.2	Neutral
SARC	Sarcoma	255	0.51	2.74e-18	24.3	57.6	18	Neutral
SKCM	Skin Cutaneous Melanoma	367	0.396	3.03e-15	19.9	62.4	17.7	Neutral
STAD	Stomach adenocarcinoma	413	0.467	8.47e-24	32.2	62.2	5.6	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.341	1.95e-05	24.7	58.7	16.7	Neutral
THCA	Thyroid carcinoma	497	0.031	0.491	0.6	98.8	0.6	Neutral
THYM	Thymoma	119	0.449	3.11e-07	12.6	87.4	0	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.317	5.73e-14	12.3	77.1	10.6	Neutral

Summary
Symbol	SMARCC1
Name	SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1
Aliases	BAF155; SRG3; CRACC1; SWI3; BRG1-associated factor 155; SWI/SNF complex 155 kDa subunit; SWI/SNF-related mat ......
Location	3p21.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.282	3.98e-09	17	408	-0.005	0.922	NS/NA
BRCA	Breast invasive carcinoma	-0.179	1.1e-07	83	785	0.001	1.6e-13	NS/NA
CESC	Cervical and endocervical cancers	-0.539	0	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.302	5.02e-08	19	297	0.002	0.0165	NS/NA
ESCA	Esophageal carcinoma	-0.25	0.00046	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.209	0.0955	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.17	7.3e-05	20	522	0.006	0.156	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.319	1.85e-09	24	319	0.039	6.49e-37	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.359	2.16e-10	23	275	0.006	1.1e-06	NS/NA
LAML	Acute Myeloid Leukemia	-0.164	0.0331	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.13	0.00276	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.177	0.000304	41	373	-0.002	0.585	NS/NA
LUAD	Lung adenocarcinoma	-0.031	0.497	21	456	-0.004	0.545	NS/NA
LUSC	Lung squamous cell carcinoma	-0.053	0.3	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.667	0.0589	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.041	0.582	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.362	4.35e-07	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.184	2.06e-05	35	498	0.001	0.451	NS/NA
READ	Rectum adenocarcinoma	-0.233	0.0194	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.244	6.88e-05	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.242	1.1e-07	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.362	8.66e-13	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.326	3.6e-05	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.09	0.033	50	509	0	0.878	NS/NA
THYM	Thymoma	-0.285	0.00154	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.196	2.26e-05	34	431	-0.009	0.907	NS/NA

Summary
Symbol	SMARCC1
Name	SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1
Aliases	BAF155; SRG3; CRACC1; SWI3; BRG1-associated factor 155; SWI/SNF complex 155 kDa subunit; SWI/SNF-related mat ......
Location	3p21.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	0	Not detected
Appendix	3	High
Bone marrow	3	High
Breast	2	Medium
Bronchus	2	Medium
Caudate	1	Low
Cerebellum	2	Medium
Cerebral cortex	1	Low
Cervix, uterine	2	Medium
Colon	2	Medium
Duodenum	2	Medium
Endometrium	2	Medium
Epididymis	2	Medium
Esophagus	3	High
Fallopian tube	2	Medium
Gallbladder	2	Medium
Heart muscle	1	Low
Hippocampus	2	Medium
Kidney	2	Medium
Liver	1	Low
Lung	1	Low
Lymph node	3	High
Nasopharynx	2	Medium
Oral mucosa	3	High
Ovary	2	Medium
Pancreas	2	Medium
Parathyroid gland	2	Medium
Placenta	3	High
Prostate	2	Medium
Rectum	2	Medium
Salivary gland	0	Not detected
Seminal vesicle	1	Low
Skeletal muscle	1	Low
Skin	2	Medium
Small intestine	2	Medium
Smooth muscle	0	Not detected
Soft tissue	0	Not detected
Spleen	2	Medium
Stomach	2	Medium
Testis	3	High
Thyroid gland	2	Medium
Tonsil	3	High
Urinary bladder	2	Medium
Vagina	3	High

Summary
Symbol	SMARCC1
Name	SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1
Aliases	BAF155; SRG3; CRACC1; SWI3; BRG1-associated factor 155; SWI/SNF complex 155 kDa subunit; SWI/SNF-related mat ......
Location	3p21.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.247	NS	24476821
BRCA	Breast invasive carcinoma	521	3.56e-05	Significant	23000897
COAD	Colon adenocarcinoma	149	1.87e-07	Significant	22810696
GBM	Glioblastoma multiforme	157	2.95e-07	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	0.000235	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.867	NS	26536169
LGG	Brain Lower Grade Glioma	513	3e-12	Significant	26824661
LUAD	Lung adenocarcinoma	230	0.0426	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	0.000149	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	1.91e-08	Significant	21720365
PRAD	Prostate adenocarcinoma	333	0.25	NS	26544944
READ	Rectum adenocarcinoma	67	0.0088	Significant	22810696
SKCM	Skin Cutaneous Melanoma	315	0.000385	Significant	26091043
STAD	Stomach adenocarcinoma	277	0.00161	Significant	25079317
THCA	Thyroid carcinoma	391	2.86e-12	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.747	NS	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	1.004	0.984	NS
BRCA	Breast invasive carcinoma	1079	1.174	0.485	NS
CESC	Cervical and endocervical cancers	291	1.531	0.191	NS
COAD	Colon adenocarcinoma	439	0.541	0.0235	Longer
ESCA	Esophageal carcinoma	184	1.23	0.527	NS
GBM	Glioblastoma multiforme	158	0.811	0.414	NS
HNSC	Head and Neck squamous cell carcinoma	518	0.953	0.814	NS
KIRC	Kidney renal clear cell carcinoma	531	0.675	0.0629	NS
KIRP	Kidney renal papillary cell carcinoma	287	0.753	0.482	NS
LAML	Acute Myeloid Leukemia	149	0.427	0.00316	Longer
LGG	Brain Lower Grade Glioma	511	0.789	0.346	NS
LIHC	Liver hepatocellular carcinoma	365	1.802	0.0156	Shorter
LUAD	Lung adenocarcinoma	502	1.038	0.864	NS
LUSC	Lung squamous cell carcinoma	494	0.761	0.169	NS
OV	Ovarian serous cystadenocarcinoma	303	0.863	0.474	NS
PAAD	Pancreatic adenocarcinoma	177	1.238	0.458	NS
PCPG	Pheochromocytoma and Paraganglioma	179	3.353	0.266	NS
PRAD	Prostate adenocarcinoma	497	1658604105.204	0.152	NS
READ	Rectum adenocarcinoma	159	0.213	0.00416	Longer
SARC	Sarcoma	259	2.723	0.000752	Shorter
SKCM	Skin Cutaneous Melanoma	459	1.303	0.166	NS
STAD	Stomach adenocarcinoma	388	0.976	0.914	NS
TGCT	Testicular Germ Cell Tumors	134	0.482	0.543	NS
THCA	Thyroid carcinoma	500	6.232	0.0502	NS
THYM	Thymoma	119	0	0.00207	Longer
UCEC	Uterine Corpus Endometrial Carcinoma	543	1.208	0.527	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	-0.043	0.39	NS
BRCA	Breast invasive carcinoma	1071	-0.024	0.432	NS
CESC	Cervical and endocervical cancers	167	0.006	0.935	NS
COAD	Colon adenocarcinoma	445	-0.051	0.279	NS
ESCA	Esophageal carcinoma	162	-0.043	0.585	NS
HNSC	Head and Neck squamous cell carcinoma	448	0.01	0.84	NS
KIRC	Kidney renal clear cell carcinoma	531	-0.103	0.018	Lower
KIRP	Kidney renal papillary cell carcinoma	260	-0.036	0.567	NS
LIHC	Liver hepatocellular carcinoma	347	0.083	0.121	NS
LUAD	Lung adenocarcinoma	507	0.07	0.116	NS
LUSC	Lung squamous cell carcinoma	497	-0.028	0.534	NS
OV	Ovarian serous cystadenocarcinoma	302	-0.124	0.0312	Lower
PAAD	Pancreatic adenocarcinoma	176	0.1	0.186	NS
READ	Rectum adenocarcinoma	156	-0.013	0.869	NS
SKCM	Skin Cutaneous Melanoma	410	-0.054	0.278	NS
STAD	Stomach adenocarcinoma	392	0.009	0.853	NS
TGCT	Testicular Germ Cell Tumors	81	0.107	0.343	NS
THCA	Thyroid carcinoma	499	0.018	0.695	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.002	0.962	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	0.059	0.336	NS
HNSC	Head and Neck squamous cell carcinoma	498	0.073	0.105	NS
KIRC	Kidney renal clear cell carcinoma	525	-0.053	0.228	NS
LGG	Brain Lower Grade Glioma	514	0.061	0.164	NS
LIHC	Liver hepatocellular carcinoma	366	0.295	8.49e-09	Higher
OV	Ovarian serous cystadenocarcinoma	296	-0.06	0.306	NS
PAAD	Pancreatic adenocarcinoma	176	0.046	0.546	NS
STAD	Stomach adenocarcinoma	406	-0.121	0.0145	Lower
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.171	7.47e-05	Higher

Summary
Symbol	SMARCC1
Name	SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1
Aliases	BAF155; SRG3; CRACC1; SWI3; BRG1-associated factor 155; SWI/SNF complex 155 kDa subunit; SWI/SNF-related mat ......
Location	3p21.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	SMARCC1
Name	SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1
Aliases	BAF155; SRG3; CRACC1; SWI3; BRG1-associated factor 155; SWI/SNF complex 155 kDa subunit; SWI/SNF-related mat ......
Location	3p21.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for SMARCC1.

Summary
Symbol	SMARCC1
Name	SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1
Aliases	BAF155; SRG3; CRACC1; SWI3; BRG1-associated factor 155; SWI/SNF complex 155 kDa subunit; SWI/SNF-related mat ......
Location	3p21.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining [ TOP ]
There is no record for SMARCC1.