CR2Cancer

Summary
Symbol	SND1
Name	staphylococcal nuclease and tudor domain containing 1
Aliases	TDRD11; p100 EBNA2 co-activator; Tudor-SN; 100 kDa coactivator; EBNA-2 co-activator (100kD); EBNA2 coactivat ......
Location	7q32.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

[ TOP ]

Domain

PF00565 Staphylococcal nuclease homologue
PF00567 Tudor domain

Function

Functions as a bridging factor between STAT6 and the basal transcription factor. Plays a role in PIM1 regulation of MYB activity. Functions as a transcriptional coactivator for the Epstein-Barr virus nuclear antigen 2 (EBNA2).

Classification

Class	Modification	Substrate	Product	PubMed
#	#	#	#	#

> Gene Ontology [ TOP ]
Biological Process	GO:0001503 ossification GO:0001649 osteoblast differentiation GO:0006401 RNA catabolic process GO:0016458 gene silencing GO:0019439 aromatic compound catabolic process GO:0031047 gene silencing by RNA GO:0034655 nucleobase-containing compound catabolic process GO:0044270 cellular nitrogen compound catabolic process GO:0046700 heterocycle catabolic process GO:0090305 nucleic acid phosphodiester bond hydrolysis GO:1901361 organic cyclic compound catabolic process
Molecular Function	GO:0004518 nuclease activity GO:0045296 cadherin binding GO:0050839 cell adhesion molecule binding GO:0098631 protein binding involved in cell adhesion GO:0098632 protein binding involved in cell-cell adhesion GO:0098641 cadherin binding involved in cell-cell adhesion
Cellular Component	GO:0005913 cell-cell adherens junction GO:0016442 RISC complex GO:0031332 RNAi effector complex GO:0042470 melanosome GO:0048770 pigment granule GO:0097433 dense body

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-1643685: Disease R-HSA-5663202: Diseases of signal transduction R-HSA-6802957: Oncogenic MAPK signaling R-HSA-6802952: Signaling by BRAF and RAF fusions

Summary
Symbol	SND1
Name	staphylococcal nuclease and tudor domain containing 1
Aliases	TDRD11; p100 EBNA2 co-activator; Tudor-SN; 100 kDa coactivator; EBNA-2 co-activator (100kD); EBNA2 coactivat ......
Location	7q32.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM4628582	c.2143C>T	p.R715C	Substitution - Missense	Large_intestine
COSM744653	c.2403C>T	p.I801I	Substitution - coding silent	Lung
COSM1635110	c.2634C>G	p.Y878*	Substitution - Nonsense	Liver
COSM203452	c.2298C>T	p.Y766Y	Substitution - coding silent	Cervix
COSM5756966	c.1979A>G	p.H660R	Substitution - Missense	Large_intestine
COSM4791817	c.1847C>T	p.A616V	Substitution - Missense	Liver
COSM3877918	c.2304+1G>A	p.?	Unknown	Oesophagus
COSM3662909	c.1536A>G	p.Q512Q	Substitution - coding silent	Liver
COSM5607055	c.2198G>A	p.G733E	Substitution - Missense	Skin
COSM5818666	c.1715A>T	p.Q572L	Substitution - Missense	Liver
COSM1330096	c.969G>A	p.L323L	Substitution - coding silent	Ovary
COSM87952	c.6_7ins21	p.A2_S3insSSAQSGG	Insertion - In frame	Central_nervous_system
COSM5817286	c.2194A>T	p.R732W	Substitution - Missense	Liver
COSM744655	c.1585G>T	p.A529S	Substitution - Missense	Lung
COSM5607055	c.2198G>A	p.G733E	Substitution - Missense	Skin
COSM5764658	c.443G>A	p.R148Q	Substitution - Missense	Large_intestine
COSM203430	c.1171C>T	p.R391C	Substitution - Missense	Large_intestine
COSM4841908	c.241C>G	p.P81A	Substitution - Missense	Cervix
COSM5406433	c.163C>T	p.R55C	Substitution - Missense	Skin
COSM5746796	c.284T>C	p.V95A	Substitution - Missense	Pancreas
COSM3877922	c.2629G>A	p.E877K	Substitution - Missense	Stomach
COSM1447861	c.697C>T	p.R233W	Substitution - Missense	Large_intestine
COSM3877890	c.656T>C	p.V219A	Substitution - Missense	Stomach
COSM1085185	c.1774C>T	p.R592*	Substitution - Nonsense	Endometrium
COSM4587101	c.2178C>T	p.G726G	Substitution - coding silent	Bone
COSM3877893	c.1145A>G	p.N382S	Substitution - Missense	Stomach
COSM3877892	c.1120C>T	p.R374*	Substitution - Nonsense	Stomach
COSM1226966	c.1163A>G	p.K388R	Substitution - Missense	Large_intestine
COSM1622313	c.1959delG	p.E655fs*15	Deletion - Frameshift	Liver
COSM4643135	c.2134G>T	p.E712*	Substitution - Nonsense	Large_intestine
COSM5570072	c.1532C>G	p.T511S	Substitution - Missense	Prostate
COSM4825299	c.1164G>C	p.K388N	Substitution - Missense	Cervix
COSM1085183	c.1394A>G	p.Y465C	Substitution - Missense	Endometrium
COSM5810020	c.936G>T	p.R312S	Substitution - Missense	Liver
COSM3632989	c.1319G>T	p.C440F	Substitution - Missense	Skin
COSM5549257	c.742G>T	p.A248S	Substitution - Missense	Prostate
COSM5928983	c.974T>A	p.I325K	Substitution - Missense	Skin
COSM4922509	c.367A>G	p.I123V	Substitution - Missense	Liver
COSM1085173	c.13G>A	p.A5T	Substitution - Missense	Endometrium
COSM2768784	c.2163delC	p.P723fs*2	Deletion - Frameshift	Large_intestine
COSM1085177	c.522G>A	p.R174R	Substitution - coding silent	Endometrium
COSM3632985	c.722C>T	p.P241L	Substitution - Missense	Skin
COSM4779521	c.2110+1G>A	p.?	Unknown	Liver
COSM1240269	c.2680C>T	p.R894C	Substitution - Missense	Stomach
COSM3778081	c.1455-1G>A	p.?	Unknown	Urinary_tract
COSM5496161	c.44C>T	p.A15V	Substitution - Missense	Biliary_tract
COSM1085202	c.1900G>A	p.A634T	Substitution - Missense	Endometrium
COSM5710405	c.710G>A	p.G237D	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1085174	c.79-1G>T	p.?	Unknown	Endometrium
COSM3877921	c.2584A>G	p.M862V	Substitution - Missense	Stomach
COSM5549257	c.742G>T	p.A248S	Substitution - Missense	Prostate
COSM4425905	c.2395G>A	p.A799T	Substitution - Missense	Pancreas
COSM484771	c.513T>C	p.H171H	Substitution - coding silent	Kidney
COSM1240269	c.2680C>T	p.R894C	Substitution - Missense	Oesophagus
COSM4936630	c.1427A>G	p.Y476C	Substitution - Missense	Liver
COSM203430	c.1171C>T	p.R391C	Substitution - Missense	Stomach
COSM2768710	c.1288G>A	p.E430K	Substitution - Missense	Large_intestine
COSM5549257	c.742G>T	p.A248S	Substitution - Missense	Prostate
COSM331531	c.1026G>C	p.Q342H	Substitution - Missense	Lung
COSM4933954	c.1969G>C	p.V657L	Substitution - Missense	Liver
COSM1447860	c.645T>C	p.D215D	Substitution - coding silent	Large_intestine
COSM1085176	c.140G>A	p.R47Q	Substitution - Missense	Endometrium
COSM3877891	c.1116C>T	p.S372S	Substitution - coding silent	Stomach
COSM4161762	c.1744A>T	p.T582S	Substitution - Missense	Thyroid
COSM4531291	c.1775G>C	p.R592P	Substitution - Missense	Skin
COSM3715605	c.2098G>A	p.D700N	Substitution - Missense	Upper_aerodigestive_tract
COSM3877917	c.2283C>A	p.V761V	Substitution - coding silent	Stomach
COSM2768784	c.2163delC	p.P723fs*2	Deletion - Frameshift	Large_intestine
COSM3877918	c.2304+1G>A	p.?	Unknown	Stomach
COSM1085179	c.733G>T	p.A245S	Substitution - Missense	Endometrium
COSM1085181	c.922G>A	p.A308T	Substitution - Missense	Endometrium
COSM4480525	c.2428C>G	p.R810G	Substitution - Missense	Skin
COSM4951017	c.1175C>A	p.P392H	Substitution - Missense	Liver
COSM1622312	c.1780-8T>A	p.?	Unknown	Liver
COSM1742318	c.2473C>G	p.Q825E	Substitution - Missense	Urinary_tract
COSM4967655	c.1872G>T	p.E624D	Substitution - Missense	Pancreas
COSM82383	c.2382G>C	p.T794T	Substitution - coding silent	Ovary
COSM3831821	c.2149G>T	p.D717Y	Substitution - Missense	Breast
COSM3877887	c.119G>T	p.R40L	Substitution - Missense	Stomach
COSM5686810	c.1516G>T	p.D506Y	Substitution - Missense	Soft_tissue
COSM3632999	c.2180C>T	p.S727F	Substitution - Missense	Skin
COSM1622309	c.520C>T	p.R174W	Substitution - Missense	Liver
COSM1266342	c.417G>C	p.M139I	Substitution - Missense	Oesophagus
COSM1226967	c.2045A>G	p.Y682C	Substitution - Missense	Large_intestine
COSM452278	c.2661C>T	p.S887S	Substitution - coding silent	Breast
COSM1496527	c.313C>T	p.Q105*	Substitution - Nonsense	Kidney
COSM1447875	c.2382G>A	p.T794T	Substitution - coding silent	Lung
COSM421602	c.1956G>A	p.Q652Q	Substitution - coding silent	Urinary_tract
COSM1085178	c.663C>A	p.V221V	Substitution - coding silent	Endometrium
COSM4417219	c.2506G>A	p.G836S	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1755061	c.1685G>A	p.R562K	Substitution - Missense	Urinary_tract
COSM1673517	c.182G>A	p.R61H	Substitution - Missense	Large_intestine
COSM452276	c.118C>T	p.R40C	Substitution - Missense	Breast
COSM3632984	c.574C>T	p.Q192*	Substitution - Nonsense	Skin
COSM127193	c.2235-2A>C	p.?	Unknown	Upper_aerodigestive_tract
COSM744658	c.360G>T	p.G120G	Substitution - coding silent	Lung
COSM4830186	c.112C>G	p.Q38E	Substitution - Missense	Cervix
COSM5492302	c.2163_2164insC	p.V724fs*42	Insertion - Frameshift	Biliary_tract
COSM3632985	c.722C>T	p.P241L	Substitution - Missense	Skin
COSM1447864	c.1535delA	p.A514fs*156	Deletion - Frameshift	Large_intestine
COSM3698152	c.2239C>T	p.R747C	Substitution - Missense	Large_intestine
COSM5607055	c.2198G>A	p.G733E	Substitution - Missense	Skin
COSM5476729	c.1435C>T	p.L479L	Substitution - coding silent	Large_intestine
COSM4951017	c.1175C>A	p.P392H	Substitution - Missense	Liver
COSM1635109	c.1969-8A>T	p.?	Unknown	Liver
COSM3662910	c.1609G>A	p.G537S	Substitution - Missense	Liver
COSM1447863	c.1254G>A	p.T418T	Substitution - coding silent	Large_intestine
COSM4846678	c.835C>T	p.H279Y	Substitution - Missense	Cervix
COSM4153811	c.1878G>A	p.A626A	Substitution - coding silent	Ovary
COSM4587102	c.2326C>T	p.R776C	Substitution - Missense	Bone
COSM1622308	c.65G>T	p.G22V	Substitution - Missense	Liver
COSM1673518	c.298G>A	p.E100K	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3396669	c.1189C>A	p.P397T	Substitution - Missense	Prostate
COSM1226965	c.1879C>G	p.L627V	Substitution - Missense	Large_intestine
COSM4161764	c.2064T>C	p.T688T	Substitution - coding silent	Thyroid
COSM3662909	c.1536A>G	p.Q512Q	Substitution - coding silent	Liver
COSM1085182	c.981A>C	p.R327S	Substitution - Missense	Endometrium
COSM452278	c.2661C>T	p.S887S	Substitution - coding silent	Stomach
COSM3662910	c.1609G>A	p.G537S	Substitution - Missense	Liver
COSM1187427	c.631C>G	p.L211V	Substitution - Missense	Lung
COSM4981576	c.62delG	p.G22fs*69	Deletion - Frameshift	Oesophagus
COSM1085206	c.2471C>T	p.T824I	Substitution - Missense	Endometrium
COSM1085184	c.1675G>T	p.E559*	Substitution - Nonsense	Endometrium
COSM1755061	c.1685G>A	p.R562K	Substitution - Missense	Urinary_tract
COSM234305	c.2404C>T	p.Q802*	Substitution - Nonsense	Skin
COSM3632990	c.1555C>T	p.P519S	Substitution - Missense	Skin
COSM1288112	c.2449G>A	p.V817I	Substitution - Missense	Autonomic_ganglia
COSM346877	c.318G>A	p.G106G	Substitution - coding silent	Lung
COSM1699332	c.1219C>T	p.R407*	Substitution - Nonsense	Skin
COSM5582583	c.2254A>G	p.K752E	Substitution - Missense	Skin
COSM1266341	c.1973G>C	p.W658S	Substitution - Missense	Oesophagus
COSM3633000	c.2523C>T	p.T841T	Substitution - coding silent	Skin
COSM3745514	c.94G>A	p.A32T	Substitution - Missense	Liver
COSM5607055	c.2198G>A	p.G733E	Substitution - Missense	Skin
COSM1288111	c.1181A>G	p.Y394C	Substitution - Missense	Autonomic_ganglia
COSM4728660	c.1134G>A	p.L378L	Substitution - coding silent	Large_intestine
COSM1447872	c.1937C>T	p.A646V	Substitution - Missense	Large_intestine
COSM3669686	c.2477G>A	p.C826Y	Substitution - Missense	Liver
COSM5647724	c.373G>A	p.E125K	Substitution - Missense	Oesophagus
COSM6007392	c.1910G>C	p.S637T	Substitution - Missense	Prostate
COSM3632983	c.429-1G>T	p.?	Unknown	Skin
COSM4477879	c.2193C>A	p.R731R	Substitution - coding silent	Skin
COSM2768700	c.748delT	p.F251fs*39	Deletion - Frameshift	Breast
COSM4926722	c.938C>A	p.A313E	Substitution - Missense	Liver
COSM1226968	c.614G>A	p.G205D	Substitution - Missense	Large_intestine
COSM5782323	c.2067G>A	p.E689E	Substitution - coding silent	Breast
COSM4805577	c.423T>A	p.A141A	Substitution - coding silent	Liver
COSM3877920	c.2547C>T	p.G849G	Substitution - coding silent	Stomach
COSM348103	c.1158G>A	p.K386K	Substitution - coding silent	Lung
COSM3632998	c.1857C>T	p.S619S	Substitution - coding silent	Skin
COSM4830186	c.112C>G	p.Q38E	Substitution - Missense	Cervix
COSM421604	c.566C>G	p.S189*	Substitution - Nonsense	Urinary_tract
COSM5647725	c.832C>T	p.L278F	Substitution - Missense	Oesophagus
COSM1085208	c.2504C>T	p.A835V	Substitution - Missense	Endometrium
COSM1085180	c.852_858delCACAGAG	p.T285fs*3	Deletion - Frameshift	Endometrium
COSM4425905	c.2395G>A	p.A799T	Substitution - Missense	Pancreas
COSM5928984	c.973A>T	p.I325L	Substitution - Missense	Skin
COSM599068	c.2155G>T	p.A719S	Substitution - Missense	Central_nervous_system
COSM1085207	c.2482C>T	p.L828F	Substitution - Missense	Endometrium
COSM3669686	c.2477G>A	p.C826Y	Substitution - Missense	Liver
COSM5756966	c.1979A>G	p.H660R	Substitution - Missense	Large_intestine
COSM1085204	c.2240G>A	p.R747H	Substitution - Missense	Endometrium
COSM1622309	c.520C>T	p.R174W	Substitution - Missense	Liver
COSM3877920	c.2547C>T	p.G849G	Substitution - coding silent	Prostate
COSM5552562	c.2416G>C	p.D806H	Substitution - Missense	Prostate
COSM5816420	c.279G>A	p.K93K	Substitution - coding silent	Liver
COSM4791817	c.1847C>T	p.A616V	Substitution - Missense	Liver
COSM4805577	c.423T>A	p.A141A	Substitution - coding silent	Liver
COSM1622308	c.65G>T	p.G22V	Substitution - Missense	Liver
COSM2768710	c.1288G>A	p.E430K	Substitution - Missense	Large_intestine
COSM3698150	c.1616G>A	p.R539H	Substitution - Missense	Large_intestine
COSM4458448	c.1085C>T	p.S362L	Substitution - Missense	Skin
COSM5026821	c.856G>A	p.E286K	Substitution - Missense	Breast
COSM3632986	c.820C>G	p.L274V	Substitution - Missense	Skin
COSM5923793	c.685C>T	p.P229S	Substitution - Missense	Skin
COSM1635108	c.510A>T	p.S170S	Substitution - coding silent	Liver
COSM377727	c.377C>T	p.S126L	Substitution - Missense	Lung
COSM3877919	c.2505C>T	p.A835A	Substitution - coding silent	Stomach
COSM1085205	c.2391C>A	p.A797A	Substitution - coding silent	Endometrium
COSM1673517	c.182G>A	p.R61H	Substitution - Missense	Large_intestine
COSM1447864	c.1535delA	p.A514fs*156	Deletion - Frameshift	Pancreas
COSM5894445	c.122G>A	p.G41D	Substitution - Missense	Skin
COSM5729977	c.1856C>T	p.S619F	Substitution - Missense	Skin
COSM1085203	c.1982A>G	p.Y661C	Substitution - Missense	Endometrium
COSM3781259	c.93C>T	p.C31C	Substitution - coding silent	Pancreas
COSM4728659	c.1112C>G	p.S371C	Substitution - Missense	Large_intestine
COSM1643233	c.2657A>G	p.K886R	Substitution - Missense	Stomach
COSM4794483	c.2576G>A	p.G859E	Substitution - Missense	Liver
COSM387825	c.2133G>T	p.M711I	Substitution - Missense	Lung
COSM5593220	c.1576C>T	p.R526C	Substitution - Missense	Skin
COSM3715605	c.2098G>A	p.D700N	Substitution - Missense	Upper_aerodigestive_tract
COSM5607055	c.2198G>A	p.G733E	Substitution - Missense	Skin
COSM3877894	c.1170G>A	p.L390L	Substitution - coding silent	Stomach
COSM5406436	c.2663C>T	p.A888V	Substitution - Missense	Skin
COSM3632987	c.864C>T	p.L288L	Substitution - coding silent	Skin
COSM378816	c.2604G>T	p.E868D	Substitution - Missense	Lung
COSM5738141	c.623T>C	p.V208A	Substitution - Missense	Small_intestine
COSM5946117	c.?	p.S578N	Substitution - Missense	Pituitary
COSM2768793	c.2456G>A	p.R819Q	Substitution - Missense	Large_intestine
COSM3877889	c.403C>A	p.R135R	Substitution - coding silent	Stomach
COSM5495849	c.88delG	p.C31fs*60	Deletion - Frameshift	Biliary_tract
COSM5549257	c.742G>T	p.A248S	Substitution - Missense	Prostate
COSM1548348	c.2554G>T	p.G852W	Substitution - Missense	Biliary_tract
COSM4387838	c.39A>G	p.G13G	Substitution - coding silent	Pancreas
COSM400390	c.612C>A	p.D204E	Substitution - Missense	Lung
COSM3703125	c.315G>A	p.Q105Q	Substitution - coding silent	Liver
COSM4425905	c.2395G>A	p.A799T	Substitution - Missense	Oesophagus
COSM1622309	c.520C>T	p.R174W	Substitution - Missense	Pancreas
COSM3662908	c.527T>G	p.L176R	Substitution - Missense	Liver
COSM2768721	c.1599C>T	p.Y533Y	Substitution - coding silent	Large_intestine
COSM3922649	c.761C>T	p.S254L	Substitution - Missense	Skin
COSM5967644	c.2455C>T	p.R819W	Substitution - Missense	Autonomic_ganglia
COSM421603	c.943G>C	p.E315Q	Substitution - Missense	Urinary_tract
COSM3669687	c.2477G>T	p.C826F	Substitution - Missense	Liver
COSM1733075	c.782T>C	p.V261A	Substitution - Missense	Pancreas
COSM1447865	c.1577G>A	p.R526H	Substitution - Missense	Large_intestine
COSM2768778	c.1938C>T	p.A646A	Substitution - coding silent	Large_intestine
COSM452278	c.2661C>T	p.S887S	Substitution - coding silent	Endometrium
COSM5782323	c.2067G>A	p.E689E	Substitution - coding silent	Breast
COSM2768725	c.1694G>A	p.R565Q	Substitution - Missense	Central_nervous_system
COSM3877895	c.1174C>T	p.P392S	Substitution - Missense	Stomach
COSM1177808	c.1127C>T	p.P376L	Substitution - Missense	Endometrium
COSM3877915	c.1825G>A	p.G609S	Substitution - Missense	Stomach
COSM1085175	c.139C>T	p.R47W	Substitution - Missense	Endometrium
COSM5665331	c.2183A>T	p.Y728F	Substitution - Missense	Soft_tissue
COSM744657	c.1432G>C	p.E478Q	Substitution - Missense	Lung
COSM1447875	c.2382G>A	p.T794T	Substitution - coding silent	Prostate
COSM2768782	c.2052C>T	p.P684P	Substitution - coding silent	Large_intestine
COSM2768784	c.2163delC	p.P723fs*2	Deletion - Frameshift	Large_intestine
COSM1622309	c.520C>T	p.R174W	Substitution - Missense	Liver
COSM78552	c.1404T>A	p.D468E	Substitution - Missense	Ovary
COSM4436545	c.2245C>T	p.R749*	Substitution - Nonsense	Oesophagus
COSM3877916	c.2110G>A	p.G704S	Substitution - Missense	Stomach
COSM4794483	c.2576G>A	p.G859E	Substitution - Missense	Liver
COSM744656	c.1494A>G	p.E498E	Substitution - coding silent	Lung
COSM3632998	c.1857C>T	p.S619S	Substitution - coding silent	Skin
COSM4728661	c.2186delC	p.R731fs*11	Deletion - Frameshift	Large_intestine
COSM1447862	c.1172G>A	p.R391H	Substitution - Missense	Large_intestine
COSM285238	c.856G>T	p.E286*	Substitution - Nonsense	Large_intestine
COSM5549257	c.742G>T	p.A248S	Substitution - Missense	Prostate
COSM3632988	c.1270C>T	p.P424S	Substitution - Missense	Skin

> Text Mining based Variations

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PMID	Variation	Cancer	Evidence
27175596	mutation	Spindle Cell Oncocytoma of the Adenohypophysis	Other SCOs demonstrated mutations in SND1 and FAT1, which are associated with MAPK pathway activation.
25985019	mutation	Lung Adenocarcinoma	In addition to ALK fusions identified by IHC/FISH in four cases, two previously known fusions involving EZR- ROS1 and KIF5B-RET were identified by RNA-Seq as well as a third novel fusion transcript that was formed between exons 1-9 of SND1 and exons 2 to 3' end of BRAF.
25189356	mutation	Prostate Carcinoma	From this genome-wide approach, mutations were found in a series of genes with prostate cancer relevance, including AR, NCOR1, KDM3A, KDM4A, CHD1, SETD5, SETD7, INPP4B, RASGRP3, RASA1, TP53BP1, and CDH1, and a novel SND1:BRAF gene fusion.

Summary
Symbol	SND1
Name	staphylococcal nuclease and tudor domain containing 1
Aliases	TDRD11; p100 EBNA2 co-activator; Tudor-SN; 100 kDa coactivator; EBNA-2 co-activator (100kD); EBNA2 coactivat ......
Location	7q32.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

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Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
Q7KZF4	103	T	Phosphothreonine	-	No	None detected
Q7KZF4	193	K	N6-acetyllysine	-	No	None detected
Q7KZF4	240	T	Phosphothreonine	-	No	None detected
Q7KZF4	426	S	Phosphoserine	-	No	None detected
Q7KZF4	641	K	N6-acetyllysine	-	No	None detected
Q7KZF4	645	S	Phosphoserine	-	No	None detected
Q7KZF4	779	T	Phosphothreonine	-	No	None detected
Q7KZF4	781	S	Phosphoserine	-	No	None detected
Q7KZF4	785	S	Phosphoserine	-	No	None detected
Q7KZF4	909	S	Phosphoserine	-	No	None detected

Summary
Symbol	SND1
Name	staphylococcal nuclease and tudor domain containing 1
Aliases	TDRD11; p100 EBNA2 co-activator; Tudor-SN; 100 kDa coactivator; EBNA-2 co-activator (100kD); EBNA2 coactivat ......
Location	7q32.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

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Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	7.567	7.71	0.138	0.322	NS
BRCA	Breast invasive carcinoma	112	1100	7.55	7.867	0.36	8.2e-15	NS
CESC	Cervical and endocervical cancers	3	306	7.657	7.437	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	7.551	8.452	0.967	4.25e-30	Over
ESCA	Esophageal carcinoma	11	185	7.852	7.638	-0.191	0.426	NS
GBM	Glioblastoma multiforme	5	166	6.921	7.399	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	7.408	7.589	0.133	0.0841	NS
KIRC	Kidney renal clear cell carcinoma	72	534	7.242	7.702	0.496	8.37e-19	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	7.271	7.826	0.526	1.24e-11	NS
LAML	Acute Myeloid Leukemia	0	173	NA	7.798	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	7.334	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	7.362	7.705	0.325	1.27e-05	NS
LUAD	Lung adenocarcinoma	59	517	7.424	7.898	0.487	2.64e-14	NS
LUSC	Lung squamous cell carcinoma	51	501	7.337	7.797	0.417	7.79e-09	NS
OV	Ovarian serous cystadenocarcinoma	0	307	NA	8.116	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	7.505	7.725	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	7.895	8.106	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	8.164	8.769	0.591	1.06e-16	Over
READ	Rectum adenocarcinoma	10	167	7.51	8.454	1.13	5.72e-11	Over
SARC	Sarcoma	2	263	7.438	7.73	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	8.024	8.749	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	7.685	7.792	0.217	0.0278	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	8.359	NA	NA	NA
THCA	Thyroid carcinoma	59	509	7.547	7.641	0.083	0.0857	NS
THYM	Thymoma	2	120	7.592	8.079	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	8.05	8.272	0.215	0.0407	NS

> Cancer Cell Line Encyclopedia (CCLE)

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Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	11
Autonomic ganglia	CHP212	9.9
Autonomic ganglia	IMR32	9.8
Autonomic ganglia	KELLY	10.4
Autonomic ganglia	KPNRTBM1	10.1
Autonomic ganglia	KPNSI9S	10.3
Autonomic ganglia	KPNYN	9.8
Autonomic ganglia	MHHNB11	11.5
Autonomic ganglia	NB1	10.6
Autonomic ganglia	NH6	10.1
Autonomic ganglia	SHSY5Y	10.5
Autonomic ganglia	SIMA	10.1
Autonomic ganglia	SKNAS	9.5
Autonomic ganglia	SKNBE2	10.1
Autonomic ganglia	SKNDZ	9.8
Autonomic ganglia	SKNFI	9.2
Autonomic ganglia	SKNSH	10
Biliary tract	HUCCT1	9.7
Biliary tract	HUH28	9.6
Biliary tract	SNU1079	10
Biliary tract	SNU1196	9.9
Biliary tract	SNU245	11.1
Biliary tract	SNU308	10.2
Biliary tract	SNU478	10.8
Bone	143B	9.8
Bone	A673	9.8
Bone	CADOES1	10
Bone	CAL78	9.8
Bone	G292CLONEA141B1	9.6
Bone	HOS	10.2
Bone	HS706T	9.9
Bone	HS737T	10.2
Bone	HS819T	10
Bone	HS821T	10.4
Bone	HS822T	10
Bone	HS863T	10.1
Bone	HS870T	9.6
Bone	HS888T	10.4
Bone	MG63	9.8
Bone	MHHES1	10
Bone	OUMS27	10.4
Bone	RDES	9.7
Bone	SJSA1	9.9
Bone	SKES1	9.8
Bone	SKNMC	9.9
Bone	SW1353	10.7
Bone	T173	9.8
Bone	TC71	10.3
Bone	U2OS	9.3
Breast	AU565	12.5
Breast	BT20	9.9
Breast	BT474	9.8
Breast	BT483	9.7
Breast	BT549	10
Breast	CAL120	10.3
Breast	CAL148	10.4
Breast	CAL51	9.5
Breast	CAL851	10.3
Breast	CAMA1	10.2
Breast	DU4475	9.6
Breast	EFM192A	10
Breast	EFM19	9.4
Breast	EVSAT	10.3
Breast	HCC1143	9.2
Breast	HCC1187	10.3
Breast	HCC1395	10.5
Breast	HCC1419	9.5
Breast	HCC1428	9.9
Breast	HCC1500	9.5
Breast	HCC1569	10.3
Breast	HCC1599	9
Breast	HCC1806	10
Breast	HCC1937	9.3
Breast	HCC1954	10
Breast	HCC202	9.8
Breast	HCC2157	9.9
Breast	HCC2218	10.5
Breast	HCC38	10.1
Breast	HCC70	10
Breast	HDQP1	10.2
Breast	HMC18	9.8
Breast	HS274T	10.3
Breast	HS281T	10.2
Breast	HS343T	10.1
Breast	HS578T	10.2
Breast	HS606T	10.4
Breast	HS739T	10.2
Breast	HS742T	9.8
Breast	JIMT1	9.7
Breast	KPL1	10
Breast	MCF7	10.1
Breast	MDAMB134VI	9.5
Breast	MDAMB157	9.9
Breast	MDAMB175VII	9.8
Breast	MDAMB231	9.7
Breast	MDAMB361	9.9
Breast	MDAMB415	9.9
Breast	MDAMB436	9.8
Breast	MDAMB453	10.2
Breast	MDAMB468	9.8
Breast	SKBR3	11.4
Breast	T47D	9.2
Breast	UACC812	9.6
Breast	UACC893	9.9
Breast	YMB1	9.7
Breast	ZR751	9.2
Breast	ZR7530	9.1
Central nervous system	1321N1	9.6
Central nervous system	42MGBA	9.9
Central nervous system	8MGBA	9.7
Central nervous system	A172	9.1
Central nervous system	AM38	10.1
Central nervous system	BECKER	10.2
Central nervous system	CAS1	10.3
Central nervous system	CCFSTTG1	10.6
Central nervous system	D283MED	9.4
Central nervous system	D341MED	11.3
Central nervous system	DAOY	10.4
Central nervous system	DBTRG05MG	10.3
Central nervous system	DKMG	9.6
Central nervous system	GAMG	10.1
Central nervous system	GB1	9.8
Central nervous system	GI1	10.3
Central nervous system	GMS10	8.9
Central nervous system	GOS3	9.9
Central nervous system	H4	10.3
Central nervous system	HS683	10.6
Central nervous system	KALS1	10.1
Central nervous system	KG1C	10.1
Central nervous system	KNS42	9.4
Central nervous system	KNS60	10.1
Central nervous system	KNS81	10.3
Central nervous system	KS1	9.9
Central nervous system	LN18	10.1
Central nervous system	LN229	10.1
Central nervous system	M059K	9.8
Central nervous system	MOGGCCM	10.5
Central nervous system	MOGGUVW	10
Central nervous system	NMCG1	10.3
Central nervous system	ONS76	10.3
Central nervous system	SF126	10
Central nervous system	SF295	10.5
Central nervous system	SNB19	10.2
Central nervous system	SNU1105	10.8
Central nervous system	SNU201	10.3
Central nervous system	SNU466	11.8
Central nervous system	SNU489	10.7
Central nervous system	SNU626	10.2
Central nervous system	SNU738	10.3
Central nervous system	SW1088	10.5
Central nervous system	SW1783	10.4
Central nervous system	T98G	10.3
Central nervous system	TM31	9.6
Central nervous system	U118MG	10
Central nervous system	U138MG	10.3
Central nervous system	U251MG	10.3
Central nervous system	U87MG	10.8
Central nervous system	YH13	10.5
Central nervous system	YKG1	9.9
Endometrium	AN3CA	10.3
Endometrium	COLO684	9.9
Endometrium	EFE184	9.4
Endometrium	EN	10.2
Endometrium	ESS1	9.9
Endometrium	HEC108	9.8
Endometrium	HEC151	10
Endometrium	HEC1A	9.8
Endometrium	HEC1B	9.9
Endometrium	HEC251	9.9
Endometrium	HEC265	9.8
Endometrium	HEC50B	10.2
Endometrium	HEC59	9.7
Endometrium	HEC6	9.7
Endometrium	ISHIKAWAHERAKLIO02ER	9.5
Endometrium	JHUEM1	9.7
Endometrium	JHUEM2	10
Endometrium	JHUEM3	9.5
Endometrium	KLE	10.6
Endometrium	MFE280	9.2
Endometrium	MFE296	9.9
Endometrium	MFE319	9.6
Endometrium	RL952	9.7
Endometrium	SNGM	10.1
Endometrium	SNU1077	10.7
Endometrium	SNU685	10.4
Endometrium	TEN	10.1
Haematopoietic and lymphoid	697	10.1
Haematopoietic and lymphoid	A3KAW	10.6
Haematopoietic and lymphoid	A4FUK	11.1
Haematopoietic and lymphoid	ALLSIL	10.4
Haematopoietic and lymphoid	AML193	9.7
Haematopoietic and lymphoid	AMO1	11.5
Haematopoietic and lymphoid	BCP1	10.2
Haematopoietic and lymphoid	BDCM	10.8
Haematopoietic and lymphoid	BL41	11.1
Haematopoietic and lymphoid	BL70	10.7
Haematopoietic and lymphoid	BV173	10.8
Haematopoietic and lymphoid	CA46	10.8
Haematopoietic and lymphoid	CI1	10.1
Haematopoietic and lymphoid	CMK115	9.9
Haematopoietic and lymphoid	CMK86	10.6
Haematopoietic and lymphoid	CMK	10.1
Haematopoietic and lymphoid	CMLT1	10
Haematopoietic and lymphoid	COLO775	11.1
Haematopoietic and lymphoid	DAUDI	10.2
Haematopoietic and lymphoid	DB	10.7
Haematopoietic and lymphoid	DEL	10.9
Haematopoietic and lymphoid	DND41	10.3
Haematopoietic and lymphoid	DOHH2	10.8
Haematopoietic and lymphoid	EB1	10.2
Haematopoietic and lymphoid	EB2	11.2
Haematopoietic and lymphoid	EHEB	10.1
Haematopoietic and lymphoid	EJM	11.1
Haematopoietic and lymphoid	EM2	10
Haematopoietic and lymphoid	EOL1	10.3
Haematopoietic and lymphoid	F36P	10.9
Haematopoietic and lymphoid	GA10	10.1
Haematopoietic and lymphoid	GDM1	9.6
Haematopoietic and lymphoid	GRANTA519	11.1
Haematopoietic and lymphoid	HDLM2	9.9
Haematopoietic and lymphoid	HDMYZ	10.4
Haematopoietic and lymphoid	HEL9217	9.6
Haematopoietic and lymphoid	HEL	9.9
Haematopoietic and lymphoid	HH	10
Haematopoietic and lymphoid	HL60	11.2
Haematopoietic and lymphoid	HPBALL	10.5
Haematopoietic and lymphoid	HS604T	9.6
Haematopoietic and lymphoid	HS611T	10.3
Haematopoietic and lymphoid	HS616T	10.2
Haematopoietic and lymphoid	HS751T	9.6
Haematopoietic and lymphoid	HT	9.8
Haematopoietic and lymphoid	HTK	10.3
Haematopoietic and lymphoid	HUNS1	9.6
Haematopoietic and lymphoid	HUT102	10
Haematopoietic and lymphoid	HUT78	9.9
Haematopoietic and lymphoid	JEKO1	10.4
Haematopoietic and lymphoid	JK1	10.9
Haematopoietic and lymphoid	JM1	10
Haematopoietic and lymphoid	JURKAT	10
Haematopoietic and lymphoid	JURLMK1	10.5
Haematopoietic and lymphoid	JVM2	10.6
Haematopoietic and lymphoid	JVM3	10
Haematopoietic and lymphoid	K562	11
Haematopoietic and lymphoid	KARPAS299	9.6
Haematopoietic and lymphoid	KARPAS422	9.9
Haematopoietic and lymphoid	KARPAS620	11.6
Haematopoietic and lymphoid	KASUMI1	9.9
Haematopoietic and lymphoid	KASUMI2	10.5
Haematopoietic and lymphoid	KASUMI6	10.3
Haematopoietic and lymphoid	KCL22	10
Haematopoietic and lymphoid	KE37	10.3
Haematopoietic and lymphoid	KE97	9.9
Haematopoietic and lymphoid	KG1	9.2
Haematopoietic and lymphoid	KHM1B	11.1
Haematopoietic and lymphoid	KIJK	10.5
Haematopoietic and lymphoid	KMH2	9.1
Haematopoietic and lymphoid	KMM1	10.5
Haematopoietic and lymphoid	KMS11	10.7
Haematopoietic and lymphoid	KMS12BM	11.3
Haematopoietic and lymphoid	KMS18	10.4
Haematopoietic and lymphoid	KMS20	10.8
Haematopoietic and lymphoid	KMS21BM	10.3
Haematopoietic and lymphoid	KMS26	10.9
Haematopoietic and lymphoid	KMS27	10.8
Haematopoietic and lymphoid	KMS28BM	11.4
Haematopoietic and lymphoid	KMS34	11.3
Haematopoietic and lymphoid	KO52	9.7
Haematopoietic and lymphoid	KOPN8	10.4
Haematopoietic and lymphoid	KU812	10.2
Haematopoietic and lymphoid	KYO1	11.3
Haematopoietic and lymphoid	L1236	10.6
Haematopoietic and lymphoid	L363	10.1
Haematopoietic and lymphoid	L428	10.6
Haematopoietic and lymphoid	L540	10.5
Haematopoietic and lymphoid	LAMA84	10.3
Haematopoietic and lymphoid	LOUCY	9.9
Haematopoietic and lymphoid	LP1	11.8
Haematopoietic and lymphoid	M07E	10.1
Haematopoietic and lymphoid	MC116	10.2
Haematopoietic and lymphoid	ME1	10.9
Haematopoietic and lymphoid	MEC1	10.3
Haematopoietic and lymphoid	MEC2	10.7
Haematopoietic and lymphoid	MEG01	10
Haematopoietic and lymphoid	MHHCALL2	9.8
Haematopoietic and lymphoid	MHHCALL3	10.6
Haematopoietic and lymphoid	MHHCALL4	9.8
Haematopoietic and lymphoid	MINO	11
Haematopoietic and lymphoid	MJ	9.7
Haematopoietic and lymphoid	MM1S	11
Haematopoietic and lymphoid	MOLM13	10.3
Haematopoietic and lymphoid	MOLM16	10.7
Haematopoietic and lymphoid	MOLM6	10.7
Haematopoietic and lymphoid	MOLP2	11.8
Haematopoietic and lymphoid	MOLP8	11
Haematopoietic and lymphoid	MOLT13	10.1
Haematopoietic and lymphoid	MOLT16	10.6
Haematopoietic and lymphoid	MOLT4	10
Haematopoietic and lymphoid	MONOMAC1	10.5
Haematopoietic and lymphoid	MONOMAC6	10.2
Haematopoietic and lymphoid	MOTN1	9.8
Haematopoietic and lymphoid	MUTZ5	10.6
Haematopoietic and lymphoid	MV411	10.5
Haematopoietic and lymphoid	NALM19	10.2
Haematopoietic and lymphoid	NALM1	10.3
Haematopoietic and lymphoid	NALM6	10
Haematopoietic and lymphoid	NAMALWA	11.5
Haematopoietic and lymphoid	NB4	10.4
Haematopoietic and lymphoid	NCIH929	10.2
Haematopoietic and lymphoid	NCO2	10.2
Haematopoietic and lymphoid	NOMO1	9.7
Haematopoietic and lymphoid	NUDHL1	10.9
Haematopoietic and lymphoid	NUDUL1	10.2
Haematopoietic and lymphoid	OCIAML2	10.1
Haematopoietic and lymphoid	OCIAML3	11.1
Haematopoietic and lymphoid	OCIAML5	10.3
Haematopoietic and lymphoid	OCILY10	10.3
Haematopoietic and lymphoid	OCILY19	10.7
Haematopoietic and lymphoid	OCILY3	10.2
Haematopoietic and lymphoid	OCIM1	10.4
Haematopoietic and lymphoid	OPM2	11.2
Haematopoietic and lymphoid	P12ICHIKAWA	10.1
Haematopoietic and lymphoid	P31FUJ	10.1
Haematopoietic and lymphoid	P3HR1	10.2
Haematopoietic and lymphoid	PCM6	11.1
Haematopoietic and lymphoid	PEER	10.2
Haematopoietic and lymphoid	PF382	9.7
Haematopoietic and lymphoid	PFEIFFER	10.3
Haematopoietic and lymphoid	PL21	10.8
Haematopoietic and lymphoid	RAJI	10.7
Haematopoietic and lymphoid	RCHACV	10.1
Haematopoietic and lymphoid	REC1	10.4
Haematopoietic and lymphoid	REH	10.2
Haematopoietic and lymphoid	RI1	11
Haematopoietic and lymphoid	RL	10.5
Haematopoietic and lymphoid	RPMI8226	11.2
Haematopoietic and lymphoid	RPMI8402	10.1
Haematopoietic and lymphoid	RS411	10.1
Haematopoietic and lymphoid	SEM	10
Haematopoietic and lymphoid	SET2	9.4
Haematopoietic and lymphoid	SIGM5	10.2
Haematopoietic and lymphoid	SKM1	10.2
Haematopoietic and lymphoid	SKMM2	11.6
Haematopoietic and lymphoid	SR786	9.5
Haematopoietic and lymphoid	ST486	10.4
Haematopoietic and lymphoid	SUDHL10	11.4
Haematopoietic and lymphoid	SUDHL1	10.2
Haematopoietic and lymphoid	SUDHL4	11.2
Haematopoietic and lymphoid	SUDHL5	10.1
Haematopoietic and lymphoid	SUDHL6	10.5
Haematopoietic and lymphoid	SUDHL8	10.4
Haematopoietic and lymphoid	SUPB15	9.9
Haematopoietic and lymphoid	SUPHD1	10.9
Haematopoietic and lymphoid	SUPM2	9.3
Haematopoietic and lymphoid	SUPT11	9.8
Haematopoietic and lymphoid	SUPT1	9.7
Haematopoietic and lymphoid	TALL1	11
Haematopoietic and lymphoid	TF1	10.6
Haematopoietic and lymphoid	THP1	9.9
Haematopoietic and lymphoid	TO175T	9.9
Haematopoietic and lymphoid	TOLEDO	10.1
Haematopoietic and lymphoid	U266B1	10.4
Haematopoietic and lymphoid	U937	10.6
Haematopoietic and lymphoid	UT7	10.1
Haematopoietic and lymphoid	WSUDLCL2	10.9
Kidney	769P	9.9
Kidney	786O	11.2
Kidney	A498	10.7
Kidney	A704	8.6
Kidney	ACHN	10.3
Kidney	BFTC909	11.1
Kidney	CAKI1	10.8
Kidney	CAKI2	9.7
Kidney	CAL54	10.2
Kidney	KMRC1	10.6
Kidney	KMRC20	11
Kidney	KMRC2	10.3
Kidney	KMRC3	9.2
Kidney	OSRC2	10.4
Kidney	RCC10RGB	10.6
Kidney	SNU1272	10.4
Kidney	SNU349	9.3
Kidney	TUHR10TKB	10.3
Kidney	TUHR14TKB	10.8
Kidney	TUHR4TKB	10.1
Kidney	VMRCRCW	10.3
Kidney	VMRCRCZ	10.6
Large intestine	C2BBE1	10.2
Large intestine	CCK81	10.1
Large intestine	CL11	10.8
Large intestine	CL14	11.1
Large intestine	CL34	10.1
Large intestine	CL40	10.7
Large intestine	COLO205	10.2
Large intestine	COLO320	11.1
Large intestine	COLO678	9.9
Large intestine	CW2	10.6
Large intestine	DLD1	9.9
Large intestine	GP2D	9.5
Large intestine	HCC56	10.5
Large intestine	HCT116	9.1
Large intestine	HCT15	9.6
Large intestine	HS675T	9.9
Large intestine	HS698T	10.3
Large intestine	HT115	10.4
Large intestine	HT29	10.3
Large intestine	HT55	9.7
Large intestine	KM12	9.5
Large intestine	LOVO	10.4
Large intestine	LS1034	10
Large intestine	LS123	9.5
Large intestine	LS180	10.3
Large intestine	LS411N	10.6
Large intestine	LS513	9.1
Large intestine	MDST8	10.3
Large intestine	NCIH508	10.4
Large intestine	NCIH716	10.7
Large intestine	NCIH747	9.8
Large intestine	OUMS23	10.7
Large intestine	RCM1	10.3
Large intestine	RKO	9.3
Large intestine	SKCO1	10.9
Large intestine	SNU1040	10.6
Large intestine	SNU1197	10.5
Large intestine	SNU175	10.4
Large intestine	SNU283	10.3
Large intestine	SNU407	10.4
Large intestine	SNU503	9.7
Large intestine	SNU61	10.6
Large intestine	SNU81	10.7
Large intestine	SNUC1	10.5
Large intestine	SNUC2A	9.7
Large intestine	SNUC4	10.2
Large intestine	SNUC5	10.7
Large intestine	SW1116	10.5
Large intestine	SW1417	10.6
Large intestine	SW1463	10.1
Large intestine	SW403	10.1
Large intestine	SW480	9.8
Large intestine	SW48	10.9
Large intestine	SW620	10
Large intestine	SW837	9.5
Large intestine	SW948	10.4
Large intestine	T84	9.7
Liver	ALEXANDERCELLS	10.3
Liver	C3A	10.2
Liver	HEP3B217	10.2
Liver	HEPG2	10.2
Liver	HLE	9
Liver	HLF	9.4
Liver	HUH1	10.3
Liver	HUH6	10.6
Liver	HUH7	10.4
Liver	JHH1	10.5
Liver	JHH2	11.4
Liver	JHH4	9.8
Liver	JHH5	9.8
Liver	JHH6	9.6
Liver	JHH7	10.3
Liver	LI7	9.2
Liver	PLCPRF5	10.2
Liver	SKHEP1	9.7
Liver	SNU182	10.1
Liver	SNU387	10.5
Liver	SNU398	9.7
Liver	SNU423	9.8
Liver	SNU449	9.8
Liver	SNU475	10
Liver	SNU761	10.1
Liver	SNU878	9.6
Liver	SNU886	9.9
Lung	A549	9.7
Lung	ABC1	9.7
Lung	BEN	10.5
Lung	CAL12T	9.2
Lung	CALU1	9.9
Lung	CALU3	10.1
Lung	CALU6	9.9
Lung	CHAGOK1	9.2
Lung	COLO668	10.5
Lung	COLO699	10.8
Lung	CORL105	10.6
Lung	CORL23	10.3
Lung	CORL24	9.6
Lung	CORL279	10.7
Lung	CORL311	9.6
Lung	CORL47	8.8
Lung	CORL51	9.2
Lung	CORL88	9
Lung	CORL95	9.7
Lung	CPCN	9.8
Lung	DMS114	9.7
Lung	DMS153	9.9
Lung	DMS273	10.3
Lung	DMS454	8.8
Lung	DMS53	10.4
Lung	DMS79	10.5
Lung	DV90	9.9
Lung	EBC1	9.6
Lung	EPLC272H	9
Lung	HARA	9.8
Lung	HCC1171	9.8
Lung	HCC1195	9.4
Lung	HCC15	10
Lung	HCC2279	10.1
Lung	HCC2935	10.2
Lung	HCC33	9.9
Lung	HCC366	9.5
Lung	HCC4006	9.7
Lung	HCC44	10.4
Lung	HCC78	10.2
Lung	HCC827	10.1
Lung	HCC95	9.6
Lung	HLC1	10.1
Lung	HLFA	10.3
Lung	HS229T	9.8
Lung	HS618T	10.2
Lung	IALM	10.1
Lung	KNS62	9.5
Lung	LC1F	9.8
Lung	LC1SQSF	9.2
Lung	LCLC103H	10
Lung	LCLC97TM1	10.5
Lung	LK2	9.6
Lung	LOUNH91	10.6
Lung	LU65	10.3
Lung	LU99	8.6
Lung	LUDLU1	10.1
Lung	LXF289	10.2
Lung	MORCPR	9.9
Lung	NCIH1048	9.1
Lung	NCIH1092	8.6
Lung	NCIH1105	9.5
Lung	NCIH1155	9.7
Lung	NCIH1184	9.8
Lung	NCIH1299	9.5
Lung	NCIH1339	8.9
Lung	NCIH1341	10.2
Lung	NCIH1355	9
Lung	NCIH1373	9.4
Lung	NCIH1385	9.9
Lung	NCIH1395	10.5
Lung	NCIH1435	10.4
Lung	NCIH1436	9.1
Lung	NCIH1437	10.8
Lung	NCIH146	10.1
Lung	NCIH1563	8.9
Lung	NCIH1568	9.4
Lung	NCIH1573	9
Lung	NCIH1581	10.1
Lung	NCIH1618	9.7
Lung	NCIH1623	9.5
Lung	NCIH1648	9.9
Lung	NCIH1650	8.9
Lung	NCIH1651	10.1
Lung	NCIH1666	10
Lung	NCIH1693	8.9
Lung	NCIH1694	9.7
Lung	NCIH1703	9.4
Lung	NCIH1734	9.9
Lung	NCIH1755	10.8
Lung	NCIH1781	9.5
Lung	NCIH1792	9.8
Lung	NCIH1793	9.8
Lung	NCIH1836	9.5
Lung	NCIH1838	9.8
Lung	NCIH1869	10.3
Lung	NCIH1876	8.6
Lung	NCIH1915	8.8
Lung	NCIH1930	9.9
Lung	NCIH1944	9.2
Lung	NCIH1963	9
Lung	NCIH196	10.3
Lung	NCIH1975	10.2
Lung	NCIH2009	10.4
Lung	NCIH2023	9.9
Lung	NCIH2029	9.8
Lung	NCIH2030	9.7
Lung	NCIH2066	10.2
Lung	NCIH2081	9.3
Lung	NCIH2085	10.2
Lung	NCIH2087	10.2
Lung	NCIH209	9.8
Lung	NCIH2106	10.3
Lung	NCIH2110	9.1
Lung	NCIH211	9.7
Lung	NCIH2122	10
Lung	NCIH2126	10.8
Lung	NCIH2141	10.2
Lung	NCIH2170	10.5
Lung	NCIH2171	10.1
Lung	NCIH2172	9.1
Lung	NCIH2196	9.1
Lung	NCIH2227	10.3
Lung	NCIH2228	8.9
Lung	NCIH226	10.3
Lung	NCIH2286	9.7
Lung	NCIH2291	10.1
Lung	NCIH2342	9.6
Lung	NCIH2347	9.7
Lung	NCIH23	9.8
Lung	NCIH2405	10.1
Lung	NCIH2444	10.9
Lung	NCIH292	9.7
Lung	NCIH322	8.6
Lung	NCIH3255	10.5
Lung	NCIH358	9.5
Lung	NCIH441	10.7
Lung	NCIH446	9.7
Lung	NCIH460	10
Lung	NCIH510	9.1
Lung	NCIH520	9.1
Lung	NCIH522	9.9
Lung	NCIH524	10.1
Lung	NCIH526	9.8
Lung	NCIH596	9.3
Lung	NCIH647	10.1
Lung	NCIH650	9.7
Lung	NCIH661	10.3
Lung	NCIH69	10.1
Lung	NCIH727	10
Lung	NCIH810	9.2
Lung	NCIH82	10.2
Lung	NCIH838	9.3
Lung	NCIH841	10.4
Lung	NCIH854	10.7
Lung	NCIH889	10.2
Lung	PC14	9.9
Lung	RERFLCAD1	10
Lung	RERFLCAD2	9.4
Lung	RERFLCAI	9.9
Lung	RERFLCKJ	10.1
Lung	RERFLCMS	9.9
Lung	RERFLCSQ1	9.6
Lung	SBC5	10
Lung	SCLC21H	10.9
Lung	SHP77	10.3
Lung	SKLU1	9.9
Lung	SKMES1	9.2
Lung	SQ1	9.2
Lung	SW1271	9.8
Lung	SW1573	9
Lung	SW900	9.8
Lung	VMRCLCD	9.8
Lung	VMRCLCP	9.7
Oesophagus	COLO680N	9.8
Oesophagus	ECGI10	9.6
Oesophagus	KYSE140	9.6
Oesophagus	KYSE150	9.3
Oesophagus	KYSE180	9.3
Oesophagus	KYSE270	9.4
Oesophagus	KYSE30	9.8
Oesophagus	KYSE410	9.3
Oesophagus	KYSE450	10.7
Oesophagus	KYSE510	9.9
Oesophagus	KYSE520	9.6
Oesophagus	KYSE70	10.2
Oesophagus	OE19	10.1
Oesophagus	OE33	9.3
Oesophagus	TE10	9.8
Oesophagus	TE11	9.4
Oesophagus	TE14	9.5
Oesophagus	TE15	9.5
Oesophagus	TE1	10
Oesophagus	TE4	9.7
Oesophagus	TE5	8.9
Oesophagus	TE6	9.9
Oesophagus	TE8	10.2
Oesophagus	TE9	9.2
Oesophagus	TT	9.4
Ovary	59M	10.9
Ovary	A2780	10
Ovary	CAOV3	10.3
Ovary	CAOV4	9.9
Ovary	COLO704	9.8
Ovary	COV318	10.8
Ovary	COV362	9.4
Ovary	COV434	9.4
Ovary	COV504	10.4
Ovary	COV644	9.3
Ovary	EFO21	9.6
Ovary	EFO27	9.9
Ovary	ES2	10.1
Ovary	FUOV1	10.4
Ovary	HEYA8	9.1
Ovary	HS571T	9.9
Ovary	IGROV1	9.9
Ovary	JHOC5	10.1
Ovary	JHOM1	9.9
Ovary	JHOM2B	10.1
Ovary	JHOS2	8.9
Ovary	JHOS4	9.3
Ovary	KURAMOCHI	10.8
Ovary	MCAS	10
Ovary	NIHOVCAR3	9
Ovary	OAW28	9.1
Ovary	OAW42	9.6
Ovary	OC314	10.7
Ovary	OC316	10.6
Ovary	ONCODG1	9.6
Ovary	OV56	10.5
Ovary	OV7	10.3
Ovary	OV90	10.8
Ovary	OVCAR4	10.4
Ovary	OVCAR8	8.2
Ovary	OVISE	9.7
Ovary	OVK18	10.3
Ovary	OVKATE	9.5
Ovary	OVMANA	9
Ovary	OVSAHO	11.6
Ovary	OVTOKO	9.6
Ovary	RMGI	10.3
Ovary	RMUGS	9.3
Ovary	SKOV3	8.7
Ovary	SNU119	10.4
Ovary	SNU840	9.4
Ovary	SNU8	10.4
Ovary	TOV112D	9.5
Ovary	TOV21G	9.7
Ovary	TYKNU	10.6
Pancreas	ASPC1	10.1
Pancreas	BXPC3	10.2
Pancreas	CAPAN1	10.5
Pancreas	CAPAN2	9.7
Pancreas	CFPAC1	9.6
Pancreas	DANG	10.9
Pancreas	HPAC	9.8
Pancreas	HPAFII	9.4
Pancreas	HS766T	10.5
Pancreas	HUPT3	10.2
Pancreas	HUPT4	9.9
Pancreas	KCIMOH1	9.9
Pancreas	KLM1	9.9
Pancreas	KP2	9.9
Pancreas	KP3	9.2
Pancreas	KP4	10
Pancreas	L33	9.6
Pancreas	MIAPACA2	10.2
Pancreas	PANC0203	9.1
Pancreas	PANC0213	10.4
Pancreas	PANC0327	9.7
Pancreas	PANC0403	9.9
Pancreas	PANC0504	10
Pancreas	PANC0813	9.4
Pancreas	PANC1005	9.6
Pancreas	PANC1	9.5
Pancreas	PATU8902	9.3
Pancreas	PATU8988S	10
Pancreas	PATU8988T	9.6
Pancreas	PK1	9.8
Pancreas	PK45H	9.7
Pancreas	PK59	10.2
Pancreas	PL45	9.7
Pancreas	PSN1	10.1
Pancreas	QGP1	10.7
Pancreas	SNU213	9.6
Pancreas	SNU324	10.2
Pancreas	SNU410	10.2
Pancreas	SU8686	10.4
Pancreas	SUIT2	9.3
Pancreas	SW1990	9.7
Pancreas	T3M4	9.1
Pancreas	TCCPAN2	10.2
Pancreas	YAPC	9.9
Pleura	ACCMESO1	9
Pleura	DM3	10.8
Pleura	ISTMES1	10.3
Pleura	ISTMES2	10.3
Pleura	JL1	11.3
Pleura	MPP89	9.4
Pleura	MSTO211H	10.3
Pleura	NCIH2052	9.5
Pleura	NCIH2452	10.7
Pleura	NCIH28	9.9
Prostate	22RV1	10.1
Prostate	DU145	9.4
Prostate	LNCAPCLONEFGC	10
Prostate	MDAPCA2B	10.2
Prostate	NCIH660	8.9
Prostate	PC3	9.9
Prostate	VCAP	10
Salivary gland	A253	9.2
Salivary gland	YD15	10.2
Skin	A101D	11
Skin	A2058	10.3
Skin	A375	9.9
Skin	C32	10.7
Skin	CHL1	10.6
Skin	CJM	10.6
Skin	COLO679	10.9
Skin	COLO741	11
Skin	COLO783	10.4
Skin	COLO792	10
Skin	COLO800	10.4
Skin	COLO818	10.8
Skin	COLO829	11.9
Skin	COLO849	12
Skin	G361	11.1
Skin	GRM	11.1
Skin	HMCB	11
Skin	HS294T	10.9
Skin	HS600T	10
Skin	HS688AT	10.2
Skin	HS695T	10.8
Skin	HS839T	9.9
Skin	HS852T	10.1
Skin	HS895T	9.6
Skin	HS934T	10.4
Skin	HS936T	10.4
Skin	HS939T	10.6
Skin	HS940T	10.2
Skin	HS944T	10.1
Skin	HT144	10.6
Skin	IGR1	10.1
Skin	IGR37	11.1
Skin	IGR39	10.3
Skin	IPC298	10.5
Skin	K029AX	11.1
Skin	LOXIMVI	10.1
Skin	MALME3M	11.1
Skin	MDAMB435S	9.6
Skin	MELHO	10.7
Skin	MELJUSO	10.6
Skin	MEWO	9.5
Skin	RPMI7951	9.6
Skin	RVH421	10.7
Skin	SH4	10.6
Skin	SKMEL1	10.3
Skin	SKMEL24	11.4
Skin	SKMEL28	10.6
Skin	SKMEL2	10.8
Skin	SKMEL30	10.2
Skin	SKMEL31	11.7
Skin	SKMEL3	10.5
Skin	SKMEL5	10.2
Skin	UACC257	10.3
Skin	UACC62	10.6
Skin	WM115	10.6
Skin	WM1799	10
Skin	WM2664	10.9
Skin	WM793	11.4
Skin	WM88	10
Skin	WM983B	9.1
Small intestine	HUTU80	9.8
Soft tissue	A204	10.1
Soft tissue	G401	9.6
Soft tissue	G402	10.2
Soft tissue	GCT	9.7
Soft tissue	HS729	10.1
Soft tissue	HT1080	10
Soft tissue	KYM1	10
Soft tissue	MESSA	9.5
Soft tissue	RD	10.6
Soft tissue	RH30	10
Soft tissue	RH41	10.4
Soft tissue	RKN	9.8
Soft tissue	S117	10.4
Soft tissue	SJRH30	9.9
Soft tissue	SKLMS1	10.4
Soft tissue	SKUT1	9.8
Soft tissue	TE125T	10
Soft tissue	TE159T	10.1
Soft tissue	TE441T	9.7
Soft tissue	TE617T	9.9
Stomach	2313287	10.5
Stomach	AGS	9.9
Stomach	AZ521	10
Stomach	ECC10	10
Stomach	ECC12	10.1
Stomach	FU97	10.1
Stomach	GCIY	10
Stomach	GSS	10.2
Stomach	GSU	10.5
Stomach	HGC27	10.1
Stomach	HS746T	10.1
Stomach	HUG1N	10.5
Stomach	IM95	10.5
Stomach	KATOIII	10
Stomach	KE39	10.3
Stomach	LMSU	10.1
Stomach	MKN1	9.9
Stomach	MKN45	9.3
Stomach	MKN74	9.9
Stomach	MKN7	9.6
Stomach	NCCSTCK140	9.3
Stomach	NCIN87	8.9
Stomach	NUGC2	9.9
Stomach	NUGC3	9.4
Stomach	NUGC4	10.3
Stomach	OCUM1	9.9
Stomach	RERFGC1B	9.4
Stomach	SH10TC	10.4
Stomach	SNU16	10.5
Stomach	SNU1	10.2
Stomach	SNU216	10.1
Stomach	SNU520	11.4
Stomach	SNU5	9.3
Stomach	SNU601	10
Stomach	SNU620	10
Stomach	SNU668	9.8
Stomach	SNU719	10.3
Stomach	TGBC11TKB	10.2
Thyroid	8305C	10.8
Thyroid	8505C	9.7
Thyroid	BCPAP	10.2
Thyroid	BHT101	11.1
Thyroid	CAL62	10.2
Thyroid	CGTHW1	10.4
Thyroid	FTC133	10.9
Thyroid	FTC238	9.6
Thyroid	ML1	10.6
Thyroid	SW579	10.1
Thyroid	TT2609C02	10.4
Thyroid	TT	10.1
Upper aerodigestive tract	BHY	10
Upper aerodigestive tract	BICR16	10
Upper aerodigestive tract	BICR18	9.2
Upper aerodigestive tract	BICR22	9.9
Upper aerodigestive tract	BICR31	9.5
Upper aerodigestive tract	BICR56	9.9
Upper aerodigestive tract	BICR6	9.4
Upper aerodigestive tract	CAL27	10.1
Upper aerodigestive tract	CAL33	10.3
Upper aerodigestive tract	DETROIT562	9.1
Upper aerodigestive tract	FADU	9.7
Upper aerodigestive tract	HS840T	10.3
Upper aerodigestive tract	HSC2	10.2
Upper aerodigestive tract	HSC3	9.3
Upper aerodigestive tract	HSC4	9.8
Upper aerodigestive tract	PECAPJ15	9.5
Upper aerodigestive tract	PECAPJ34CLONEC12	9.2
Upper aerodigestive tract	PECAPJ41CLONED2	9.7
Upper aerodigestive tract	PECAPJ49	9.2
Upper aerodigestive tract	SCC15	9.9
Upper aerodigestive tract	SCC25	10.1
Upper aerodigestive tract	SCC4	9.9
Upper aerodigestive tract	SCC9	9.9
Upper aerodigestive tract	SNU1076	9.8
Upper aerodigestive tract	SNU1214	10.2
Upper aerodigestive tract	SNU46	10.4
Upper aerodigestive tract	SNU899	10.4
Upper aerodigestive tract	YD10B	9.9
Upper aerodigestive tract	YD38	10.1
Upper aerodigestive tract	YD8	10
Urinary tract	5637	10.2
Urinary tract	639V	10.4
Urinary tract	647V	10
Urinary tract	BC3C	9.2
Urinary tract	BFTC905	10.2
Urinary tract	CAL29	9.9
Urinary tract	HS172T	8.9
Urinary tract	HT1197	9.7
Urinary tract	HT1376	9.8
Urinary tract	J82	9.7
Urinary tract	JMSU1	10.9
Urinary tract	KMBC2	9.6
Urinary tract	KU1919	10.2
Urinary tract	RT11284	9.4
Urinary tract	RT112	9.6
Urinary tract	RT4	9.5
Urinary tract	SCABER	9.9
Urinary tract	SW1710	10.8
Urinary tract	SW780	9.1
Urinary tract	T24	9.4
Urinary tract	TCCSUP	9.6
Urinary tract	UMUC1	10.4
Urinary tract	UMUC3	10.3
Urinary tract	VMCUB1	10.3

> The Human Protein Atlas (HPA)

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Tissue	Expression Level (TPM)
Adipose tissue	55.2
Adrenal gland	59.5
Appendix	79.4
Bone marrow	41.3
Breast	68.7
Cerebral cortex	50.9
Cervix, uterine	116.1
Colon	51.4
Duodenum	55.6
Endometrium	94
Epididymis	108.7
Esophagus	47
Fallopian tube	103.2
Gallbladder	58.3
Heart muscle	29.3
Kidney	36
Liver	35.1
Lung	62.4
Lymph node	60.7
Ovary	105.9
Pancreas	36.6
Parathyroid gland	82.9
Placenta	121.5
Prostate	92.9
Rectum	54.9
Salivary gland	42.4
Seminal vesicle	79.7
Skeletal muscle	10.1
Skin	47
Small intestine	50.6
Smooth muscle	95.9
Spleen	63.4
Stomach	54
Testis	72.7
Thyroid gland	108.6
Tonsil	61.5
Urinary bladder	54.6

> Text Mining based Expression

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PMID	Expression	Cancer	Evidence
26997225	overexpression	Hepatocellular Carcinoma	Staphylococcal nuclease and tudor domain containing 1 (SND1) is overexpressed in multiple cancers, including hepatocellular carcinoma (HCC), and functions as an oncogene.
26351803	overexpression	Glioma	To elucidate the role of MDTH and SND1 in the pathogenesis of glioma, we examined the expression of MTDH and SND1 in primary glioma tissues and found that both MTDH and SND1 were highly expressed, with similar expression patterns.
25596283	overexpression	Breast Carcinoma	SND1 was upregulated in breast cancer tissues, in particular in primary invasive ductal carcinomas.
25494629	overexpression	Hepatocellular Carcinoma	Promoter activity of the cell growth- and RNA-protection associated SND1 gene is up-regulated by ER stress in human hepatoma cells.
25216670	overexpression	Glioma	SND1 is highly expressed in human glioma tissue and inversely correlated with miR-184 expression.
24918049	overexpression	Hepatocellular Carcinoma	Staphylococcal nuclease domain containing-1 (SND1) is overexpressed in human hepatocellular carcinoma (HCC) patients and promotes tumorigenesis by human HCC cells.
24155205	overexpression	Breast Carcinoma	Interestingly, we found Tudor-SN as a miRNA regulator according to microarray analysis, and further identified that Tudor-SN negatively regulated the expression of miR-127, and consequently increased the expression of the proto-oncogene BCL6 which was a convincing target of miR-127.
23995791	overexpression	Prostate Carcinoma	We found that both SAM68 and SND1 are upregulated in PCa cells with respect to benign prostate cells.
23878061	overexpression	Hepatocellular Carcinoma	Immunohistochemistry analysis revealed that the expression level of SND1 was higher in HCC tissues than in adjacent nontumor tissues.
23065261	overexpression	Colon Carcinoma	Positive expression of MTDH and SND1 were both increased in colon cancer tissues compared to paired non-cancerous colon tissues.
21520169	overexpression	Hepatocellular Carcinoma	In 109 human HCC samples SND1 was overexpressed in ≈74% cases compared to normal liver.
20883704	overexpression	Colon Carcinoma	Staphylococcal nuclease homology domain containing 1 (SND1), a component of RISC, is frequently up-regulated in human colon cancers and also chemically induced colon cancers in animals.
19435788	overexpression	Hormone-Resistant Prostate Cancer	Using high molecular-weight proteomic analysis, we previously showed that Staphylococcal nuclease domain-containing protein 1 (SND1) is highly expressed in recurrent androgen-insensitive prostate cancer tissues.
18348187	underexpression	Clear Cell Renal Cell Carcinoma	Lower levels of expression of SIN3B, TRIP3, SYNJ2BP and NDE1 (P < 0.02), and of intronic transcripts derived from SND1 and ACTN4 loci (P < 0.05), were confirmed in clear cell RCC by Real-time RT-PCR.
17909068	overexpression	Colon Carcinoma	SND1, also called Tudor-SN and p100 and recently reported to be a component of RISC, is among the list of highly expressed genes in human colon cancers.
28263968	overexpression	Breast Carcinoma	In this study, we discovered that SND1 was upregulated in breast cancer tissues, particularly the tissues from patients with distant metastases.
28403887	overexpression	Prostate Carcinoma	We then ran a factorial discriminant analysis (FDA) and compared the enriched genes in prostate-tumor biopsies and normal biopsies using ANOVA to identify significantly differentially-enriched genes. The analysis identified ALG5, EXOSC8, CBX1, GRID2, GRIN3B, ING3, MYO1D, NPHP3-AS1, MSH6, FBXO11, SND1, SPATS2, TENM4 and TRA2A genes.

Summary
Symbol	SND1
Name	staphylococcal nuclease and tudor domain containing 1
Aliases	TDRD11; p100 EBNA2 co-activator; Tudor-SN; 100 kDa coactivator; EBNA-2 co-activator (100kD); EBNA2 coactivat ......
Location	7q32.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

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Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.538	1.26e-31	12.9	54.2	32.9	Neutral
BRCA	Breast invasive carcinoma	1075	0.426	1.04e-48	14.4	58.8	26.8	Neutral
CESC	Cervical and endocervical cancers	292	0.572	9.12e-27	18.5	68.8	12.7	Neutral
COAD	Colon adenocarcinoma	449	0.524	4.67e-33	1.3	50.1	48.6	Gain
ESCA	Esophageal carcinoma	183	0.606	9.21e-20	33.9	33.9	32.2	Loss
GBM	Glioblastoma multiforme	147	0.516	2.24e-11	0	17.7	82.3	Gain
HNSC	Head and Neck squamous cell carcinoma	514	0.576	9.37e-47	22.2	59.7	18.1	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.461	6.1e-29	1.3	66.3	32.4	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.061	0.302	0.7	38.5	60.8	Gain
LAML	Acute Myeloid Leukemia	166	0.551	1.45e-14	12	88	0	Neutral
LGG	Brain Lower Grade Glioma	513	0.353	1.86e-16	0.8	64.5	34.7	Gain
LIHC	Liver hepatocellular carcinoma	364	0.514	6.89e-26	9.9	59.1	31	Neutral
LUAD	Lung adenocarcinoma	512	0.475	3.94e-30	12.5	47.1	40.4	Gain
LUSC	Lung squamous cell carcinoma	498	0.512	1.36e-34	17.9	40.2	42	Gain
OV	Ovarian serous cystadenocarcinoma	300	0.516	8.19e-22	14	42.7	43.3	Gain
PAAD	Pancreatic adenocarcinoma	177	0.536	1.49e-14	8.5	68.9	22.6	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.516	2.21e-12	5.6	81.5	13	Neutral
PRAD	Prostate adenocarcinoma	491	0.4	2.94e-20	4.5	76	19.6	Neutral
READ	Rectum adenocarcinoma	164	0.593	6.14e-17	3.7	45.1	51.2	Gain
SARC	Sarcoma	255	0.471	1.73e-15	14.9	56.1	29	Neutral
SKCM	Skin Cutaneous Melanoma	367	0.452	7.06e-20	4.1	36	59.9	Gain
STAD	Stomach adenocarcinoma	413	0.514	3.3e-29	18.6	48.7	32.7	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.633	3.59e-18	6.7	28	65.3	Gain
THCA	Thyroid carcinoma	497	0.404	6.3e-21	0	96	4	Neutral
THYM	Thymoma	119	0.191	0.0374	2.5	83.2	14.3	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.353	3.37e-17	11.4	74.5	14.2	Neutral

Summary
Symbol	SND1
Name	staphylococcal nuclease and tudor domain containing 1
Aliases	TDRD11; p100 EBNA2 co-activator; Tudor-SN; 100 kDa coactivator; EBNA-2 co-activator (100kD); EBNA2 coactivat ......
Location	7q32.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.137	0.00475	17	408	-0.001	0.0631	NS/NA
BRCA	Breast invasive carcinoma	-0.185	4.43e-08	83	785	0.133	1.03e-19	NS/NA
CESC	Cervical and endocervical cancers	-0.277	8.47e-07	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.242	1.39e-05	19	297	-0.068	0.0846	NS/NA
ESCA	Esophageal carcinoma	-0.332	2.68e-06	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.345	0.00507	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.169	7.85e-05	20	522	0.008	0.0112	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.147	0.00645	24	319	0.013	5.86e-06	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.125	0.0311	23	275	0.004	0.449	NS/NA
LAML	Acute Myeloid Leukemia	-0.329	1.33e-05	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.165	0.000145	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.202	3.69e-05	41	373	-0.001	0.000326	NS/NA
LUAD	Lung adenocarcinoma	-0.195	1.77e-05	21	456	-0.021	0.141	NS/NA
LUSC	Lung squamous cell carcinoma	-0.235	4.1e-06	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.517	0.162	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.149	0.0441	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.135	0.0646	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.092	0.0328	35	498	0.001	0.0252	NS/NA
READ	Rectum adenocarcinoma	-0.308	0.00179	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.186	0.00247	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.276	1.29e-09	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.128	0.0138	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.449	5.84e-09	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.078	0.0646	50	509	-0.003	0.283	NS/NA
THYM	Thymoma	-0.184	0.0422	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.127	0.00615	34	431	-0.004	0.0163	NS/NA

Summary
Symbol	SND1
Name	staphylococcal nuclease and tudor domain containing 1
Aliases	TDRD11; p100 EBNA2 co-activator; Tudor-SN; 100 kDa coactivator; EBNA-2 co-activator (100kD); EBNA2 coactivat ......
Location	7q32.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	2	Medium
Appendix	2	Medium
Bone marrow	3	High
Breast	2	Medium
Bronchus	2	Medium
Caudate	2	Medium
Cerebellum	3	High
Cerebral cortex	3	High
Cervix, uterine	2	Medium
Colon	2	Medium
Duodenum	2	Medium
Endometrium	3	High
Epididymis	2	Medium
Esophagus	2	Medium
Fallopian tube	2	Medium
Gallbladder	3	High
Heart muscle	0	Not detected
Hippocampus	2	Medium
Kidney	2	Medium
Liver	1	Low
Lung	2	Medium
Lymph node	2	Medium
Nasopharynx	2	Medium
Oral mucosa	1	Low
Ovary	2	Medium
Pancreas	3	High
Parathyroid gland	2	Medium
Placenta	3	High
Prostate	2	Medium
Rectum	2	Medium
Salivary gland	3	High
Seminal vesicle	2	Medium
Skeletal muscle	0	Not detected
Skin	2	Medium
Small intestine	2	Medium
Smooth muscle	1	Low
Soft tissue	0	Not detected
Spleen	2	Medium
Stomach	3	High
Testis	2	Medium
Thyroid gland	2	Medium
Tonsil	3	High
Urinary bladder	2	Medium
Vagina	1	Low

Summary
Symbol	SND1
Name	staphylococcal nuclease and tudor domain containing 1
Aliases	TDRD11; p100 EBNA2 co-activator; Tudor-SN; 100 kDa coactivator; EBNA-2 co-activator (100kD); EBNA2 coactivat ......
Location	7q32.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.202	NS	24476821
BRCA	Breast invasive carcinoma	521	2.93e-06	Significant	23000897
COAD	Colon adenocarcinoma	149	0.00852	Significant	22810696
GBM	Glioblastoma multiforme	157	0.00444	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	5.02e-07	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.0384	Significant	26536169
LGG	Brain Lower Grade Glioma	513	0.00955	Significant	26824661
LUAD	Lung adenocarcinoma	230	0.0477	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	0.349	NS	22960745
OV	Ovarian serous cystadenocarcinoma	287	4.35e-06	Significant	21720365
PRAD	Prostate adenocarcinoma	333	0.00443	Significant	26544944
READ	Rectum adenocarcinoma	67	0.0397	Significant	22810696
SKCM	Skin Cutaneous Melanoma	315	0.00014	Significant	26091043
STAD	Stomach adenocarcinoma	277	0.00653	Significant	25079317
THCA	Thyroid carcinoma	391	9.33e-05	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	7.43e-05	Significant	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	1.825	0.00722	Shorter
BRCA	Breast invasive carcinoma	1079	1.129	0.577	NS
CESC	Cervical and endocervical cancers	291	1.785	0.0755	NS
COAD	Colon adenocarcinoma	439	1.126	0.695	NS
ESCA	Esophageal carcinoma	184	0.767	0.451	NS
GBM	Glioblastoma multiforme	158	1.755	0.0238	Shorter
HNSC	Head and Neck squamous cell carcinoma	518	1.146	0.483	NS
KIRC	Kidney renal clear cell carcinoma	531	0.748	0.158	NS
KIRP	Kidney renal papillary cell carcinoma	287	1.653	0.215	NS
LAML	Acute Myeloid Leukemia	149	0.781	0.399	NS
LGG	Brain Lower Grade Glioma	511	0.591	0.0428	Longer
LIHC	Liver hepatocellular carcinoma	365	0.906	0.704	NS
LUAD	Lung adenocarcinoma	502	1.066	0.778	NS
LUSC	Lung squamous cell carcinoma	494	1.03	0.882	NS
OV	Ovarian serous cystadenocarcinoma	303	1.029	0.892	NS
PAAD	Pancreatic adenocarcinoma	177	1.249	0.48	NS
PCPG	Pheochromocytoma and Paraganglioma	179	0.884	0.902	NS
PRAD	Prostate adenocarcinoma	497	0.945	0.955	NS
READ	Rectum adenocarcinoma	159	0.972	0.966	NS
SARC	Sarcoma	259	1.593	0.0842	NS
SKCM	Skin Cutaneous Melanoma	459	1.235	0.265	NS
STAD	Stomach adenocarcinoma	388	0.722	0.159	NS
TGCT	Testicular Germ Cell Tumors	134	946949227.087	0.48	NS
THCA	Thyroid carcinoma	500	0.887	0.866	NS
THYM	Thymoma	119	0.366	0.215	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	0.503	0.0131	Longer

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	0.174	0.000413	Higher
BRCA	Breast invasive carcinoma	1071	-0.013	0.665	NS
CESC	Cervical and endocervical cancers	167	0.055	0.483	NS
COAD	Colon adenocarcinoma	445	0.043	0.369	NS
ESCA	Esophageal carcinoma	162	-0.157	0.0458	Lower
HNSC	Head and Neck squamous cell carcinoma	448	0.009	0.841	NS
KIRC	Kidney renal clear cell carcinoma	531	0.104	0.0162	Higher
KIRP	Kidney renal papillary cell carcinoma	260	0.141	0.0232	Higher
LIHC	Liver hepatocellular carcinoma	347	0.012	0.824	NS
LUAD	Lung adenocarcinoma	507	0.188	1.99e-05	Higher
LUSC	Lung squamous cell carcinoma	497	0.038	0.395	NS
OV	Ovarian serous cystadenocarcinoma	302	0.039	0.503	NS
PAAD	Pancreatic adenocarcinoma	176	-0.079	0.298	NS
READ	Rectum adenocarcinoma	156	0.106	0.189	NS
SKCM	Skin Cutaneous Melanoma	410	0.088	0.0752	NS
STAD	Stomach adenocarcinoma	392	-0.063	0.212	NS
TGCT	Testicular Germ Cell Tumors	81	-0.051	0.649	NS
THCA	Thyroid carcinoma	499	0.03	0.498	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	-0.145	0.00112	Lower

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	0.114	0.0607	NS
HNSC	Head and Neck squamous cell carcinoma	498	-0.033	0.467	NS
KIRC	Kidney renal clear cell carcinoma	525	0.205	2.15e-06	Higher
LGG	Brain Lower Grade Glioma	514	-0.04	0.37	NS
LIHC	Liver hepatocellular carcinoma	366	-0.012	0.813	NS
OV	Ovarian serous cystadenocarcinoma	296	0.026	0.658	NS
PAAD	Pancreatic adenocarcinoma	176	-0.059	0.434	NS
STAD	Stomach adenocarcinoma	406	-0.201	4.52e-05	Lower
UCEC	Uterine Corpus Endometrial Carcinoma	534	-0.278	6.12e-11	Lower

Summary
Symbol	SND1
Name	staphylococcal nuclease and tudor domain containing 1
Aliases	TDRD11; p100 EBNA2 co-activator; Tudor-SN; 100 kDa coactivator; EBNA-2 co-activator (100kD); EBNA2 coactivat ......
Location	7q32.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	SND1
Name	staphylococcal nuclease and tudor domain containing 1
Aliases	TDRD11; p100 EBNA2 co-activator; Tudor-SN; 100 kDa coactivator; EBNA-2 co-activator (100kD); EBNA2 coactivat ......
Location	7q32.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for SND1.

Summary
Symbol	SND1
Name	staphylococcal nuclease and tudor domain containing 1
Aliases	TDRD11; p100 EBNA2 co-activator; Tudor-SN; 100 kDa coactivator; EBNA-2 co-activator (100kD); EBNA2 coactivat ......
Location	7q32.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
26997225	Hepatocellular Carcinoma	partner	MGLL	negative correlation	Interaction of SND1 with MGLL resulted in ubiquitination and proteosomal degradation of MGLL. An inverse correlation between SND1 and MGLL levels was identified in a human HCC tissue microarray as well as in the TCGA database.
26351803	Glioma	partner	MTDH	positive correlation	Co-expression of MTDH and SND1 was associated with advanced glioma grades.
25985019	Lung Adenocarcinoma	partner	miR-361-5p	feedback loop	SND1 was identified as a target of miR-361-5p using bioinformatics analysis and in vitro luciferase reporter assays. In turn, SND1 bound to pre-miR-361-5p and suppressed the expression of miR-361-5p, thus exerting a feedback loop.
25596283	Breast Carcinoma	downstream	Smurf1	positive regulation	We found that SND1 promoted expression of the E3 ubiquitin ligase Smurf1, leading to RhoA ubiquitination and degradation.
25216670	Glioma	partner	miR-184	negative correlation	SND1 is highly expressed in human glioma tissue and inversely correlated with miR-184 expression.
24918049	Hepatocellular Carcinoma	downstream	AT1R	positive regulation	We now document that SND1 increases angiotensin II type 1 receptor (AT1R) levels by increasing AT1R mRNA stability. A positive correlation was observed between SND1 and AT1R expression levels in human HCC patients.
24155205	Breast Carcinoma	downstream	miR-127; BCL6	negative regulation; positive regulation	Interestingly, we found Tudor-SN as a miRNA regulator according to microarray analysis, and further identified that Tudor-SN negatively regulated the expression of miR-127, and consequently increased the expression of the proto-oncogene BCL6 which was a convincing target of miR-127.
23995791	Prostate Carcinoma	partner	SAM68	synergic effect	Upregulation of SND1 exerts a synergic effect with SAM68 on exon v5 inclusion in the CD44 mRNA.
23995791	Prostate Carcinoma	downstream	CD44	regulation	The effect of SND1 on CD44 splicing required SAM68, as it was compromised after knockdown of this protein or mutation of the SAM68-binding sites in the CD44 pre-mRNA.
23878061	Hepatocellular Carcinoma	downstream	IGFBP3; IGF signaling pathway	negative regulation; positive regulation	Screening of gene expression levels of the IGF pathway, using real-time PCR, revealed that a decrease in SND1 expression could increase the expression of IGF-binding protein 3 (IGFBP3), which can negatively regulate activation of the IGF pathway by restricting interactions between IGF and IGF receptors. Therefore, we concluded that SND1 could affect SMMC-7721 cells proliferation by regulating IGFBP3 expression and IGF signaling pathway.
23065261	Colon Carcinoma	partner	MTDH	positive correlation	There was a positive correlation between MTDH and SND1 expression in colon cancer tissues (r = 0.86, p < 0.001).
21520169	Hepatocellular Carcinoma	downstream	RISC	positive regulation	We unravel a novel mechanism that overexpression of AEG-1 and SND1 leading to increased RISC activity might contribute to hepatocarcinogenesis.
20883704	Colon Carcinoma	downstream	APC	negative regulation	We here showed that SDN1 is involved in miRNA-mediated gene suppression and overexpression of SND1 in colon cancer cells causes down-regulation of APC without altering APC mRNA levels.