Browse STK31 in pancancer

Summary
Symbol	STK31
Name	serine/threonine kinase 31
Aliases	TDRD8; SgK396; serine/threonine-protein kinase NYD-SPK; sugen kinase 396; tudor domain containing 8; Serine/ ......
Location	7p15.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

Domain

PF00069 Protein kinase domain
PF00567 Tudor domain

Function

-

Classification

Class	Modification	Substrate	Product	PubMed
#	#	#	#	#

> Gene Ontology [ TOP ]
Biological Process	GO:0006401 RNA catabolic process GO:0019439 aromatic compound catabolic process GO:0034655 nucleobase-containing compound catabolic process GO:0044270 cellular nitrogen compound catabolic process GO:0046700 heterocycle catabolic process GO:0090305 nucleic acid phosphodiester bond hydrolysis GO:1901361 organic cyclic compound catabolic process
Molecular Function	GO:0004518 nuclease activity GO:0004674 protein serine/threonine kinase activity
Cellular Component	GO:0001669 acrosomal vesicle GO:0030141 secretory granule GO:0097223 sperm part GO:0099503 secretory vesicle

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	-

Summary
Symbol	STK31
Name	serine/threonine kinase 31
Aliases	TDRD8; SgK396; serine/threonine-protein kinase NYD-SPK; sugen kinase 396; tudor domain containing 8; Serine/ ......
Location	7p15.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]

> Catalogue of Somatic Mutations in Cancer (COSMIC)

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM1329892	c.2786A>G	p.E929G	Substitution - Missense	Ovary
COSM3923411	c.1893C>T	p.S631S	Substitution - coding silent	Skin
COSM150251	c.1417-10C>A	p.?	Unknown	Large_intestine
COSM485218	c.1399C>T	p.R467C	Substitution - Missense	Central_nervous_system
COSM3723731	c.2108T>C	p.L703P	Substitution - Missense	Upper_aerodigestive_tract
COSM3663115	c.2729A>T	p.D910V	Substitution - Missense	Liver
COSM3923408	c.1463G>A	p.G488E	Substitution - Missense	Skin
COSM306066	c.1140C>T	p.V380V	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM5737884	c.335G>T	p.R112M	Substitution - Missense	Small_intestine
COSM452874	c.150+1G>T	p.?	Unknown	Breast
COSM1686020	c.2179G>A	p.E727K	Substitution - Missense	Skin
COSM3637560	c.2483C>T	p.S828L	Substitution - Missense	Oesophagus
COSM4654235	c.2170A>G	p.M724V	Substitution - Missense	Liver
COSM4550356	c.499G>A	p.G167R	Substitution - Missense	Skin
COSM3637559	c.2425G>A	p.V809I	Substitution - Missense	Skin
COSM5812645	c.1179T>A	p.A393A	Substitution - coding silent	Liver
COSM134163	c.2629A>T	p.K877*	Substitution - Nonsense	Skin
COSM746380	c.1298A>T	p.E433V	Substitution - Missense	Lung
COSM1088624	c.955G>A	p.A319T	Substitution - Missense	Endometrium
COSM4451696	c.135A>G	p.V45V	Substitution - coding silent	Skin
COSM1088632	c.1322G>T	p.R441I	Substitution - Missense	Endometrium
COSM4975924	c.2661G>C	p.M887I	Substitution - Missense	Oesophagus
COSM4004435	c.1229G>A	p.G410E	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3923412	c.2375C>T	p.P792L	Substitution - Missense	Skin
COSM1227878	c.936A>C	p.K312N	Substitution - Missense	Large_intestine
COSM1622714	c.733C>T	p.H245Y	Substitution - Missense	Liver
COSM600550	c.2324C>T	p.A775V	Substitution - Missense	Liver
COSM5723872	c.948G>A	p.E316E	Substitution - coding silent	Skin
COSM5407251	c.620G>A	p.G207E	Substitution - Missense	Skin
COSM3715731	c.1965+2T>C	p.?	Unknown	Upper_aerodigestive_tract
COSM5407254	c.2561C>T	p.S854L	Substitution - Missense	Skin
COSM1227877	c.2916C>A	p.F972L	Substitution - Missense	Large_intestine
COSM1622714	c.733C>T	p.H245Y	Substitution - Missense	Liver
COSM1488481	c.1141G>T	p.D381Y	Substitution - Missense	Breast
COSM98824	c.1015C>A	p.Q339K	Substitution - Missense	Stomach
COSM1720580	c.902A>G	p.K301R	Substitution - Missense	Skin
COSM1088658	c.2652G>A	p.S884S	Substitution - coding silent	Endometrium
COSM485220	c.2577T>C	p.N859N	Substitution - coding silent	Kidney
COSM1698424	c.2005G>A	p.E669K	Substitution - Missense	Skin
COSM6012637	c.2853C>T	p.L951L	Substitution - coding silent	Skin
COSM1488482	c.1673C>G	p.T558S	Substitution - Missense	Breast
COSM5644415	c.1493T>A	p.F498Y	Substitution - Missense	Oesophagus
COSM1698419	c.729G>A	p.W243*	Substitution - Nonsense	Skin
COSM5695820	c.1442T>A	p.V481E	Substitution - Missense	Soft_tissue
COSM1088622	c.630G>A	p.E210E	Substitution - coding silent	Endometrium
COSM3637540	c.1198G>A	p.G400R	Substitution - Missense	Skin
COSM3026299	c.1484T>C	p.L495P	Substitution - Missense	Bone
COSM233509	c.1092G>A	p.M364I	Substitution - Missense	Skin
COSM306066	c.1140C>T	p.V380V	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM1159236	c.1900A>G	p.K634E	Substitution - Missense	Pancreas
COSM1450076	c.1236G>T	p.E412D	Substitution - Missense	Large_intestine
COSM3736437	c.781G>A	p.E261K	Substitution - Missense	Thyroid
COSM3637558	c.2407C>T	p.P803S	Substitution - Missense	Skin
COSM3715731	c.1965+2T>C	p.?	Unknown	Upper_aerodigestive_tract
COSM3637533	c.371G>A	p.R124Q	Substitution - Missense	Skin
COSM106988	c.2248G>A	p.V750I	Substitution - Missense	Skin
COSM3736438	c.804G>T	p.K268N	Substitution - Missense	Skin
COSM1450071	c.7G>A	p.V3I	Substitution - Missense	Large_intestine
COSM452877	c.2240G>C	p.R747P	Substitution - Missense	Breast
COSM3394690	c.231G>T	p.G77G	Substitution - coding silent	Pancreas
COSM1488480	c.1045A>G	p.T349A	Substitution - Missense	Breast
COSM3923410	c.1662C>T	p.I554I	Substitution - coding silent	Skin
COSM1622716	c.977C>T	p.A326V	Substitution - Missense	Liver
COSM4528079	c.150G>A	p.Q50Q	Substitution - coding silent	Skin
COSM4902510	c.2879C>T	p.S960L	Substitution - Missense	Skin
COSM5789492	c.452C>T	p.P151L	Substitution - Missense	Breast
COSM5820742	c.1297G>A	p.E433K	Substitution - Missense	Liver
COSM1227875	c.2183G>A	p.R728Q	Substitution - Missense	Large_intestine
COSM1698425	c.2119C>T	p.H707Y	Substitution - Missense	Skin
COSM4730573	c.3003G>T	p.E1001D	Substitution - Missense	Large_intestine
COSM76621	c.1756A>G	p.S586G	Substitution - Missense	Ovary
COSM233509	c.1092G>A	p.M364I	Substitution - Missense	Skin
COSM1088650	c.2086G>A	p.A696T	Substitution - Missense	Endometrium
COSM3637562	c.2488G>A	p.E830K	Substitution - Missense	Skin
COSM3637547	c.1714G>A	p.D572N	Substitution - Missense	Skin
COSM1698427	c.2765C>T	p.S922F	Substitution - Missense	Skin
COSM1450081	c.2024G>A	p.R675H	Substitution - Missense	Large_intestine
COSM746382	c.1180A>C	p.I394L	Substitution - Missense	Lung
COSM3923414	c.2916C>T	p.F972F	Substitution - coding silent	Skin
COSM3637533	c.371G>A	p.R124Q	Substitution - Missense	Skin
COSM3374597	c.2929G>C	p.E977Q	Substitution - Missense	Thyroid
COSM3394690	c.231G>T	p.G77G	Substitution - coding silent	Pancreas
COSM485218	c.1399C>T	p.R467C	Substitution - Missense	Kidney
COSM109203	c.2308G>A	p.V770M	Substitution - Missense	Skin
COSM4004435	c.1229G>A	p.G410E	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3637544	c.1610C>T	p.S537F	Substitution - Missense	Skin
COSM3637562	c.2488G>A	p.E830K	Substitution - Missense	Skin
COSM326577	c.2172G>T	p.M724I	Substitution - Missense	Lung
COSM3637539	c.1172C>T	p.S391L	Substitution - Missense	Skin
COSM3637549	c.1786G>A	p.E596K	Substitution - Missense	Skin
COSM4902510	c.2879C>T	p.S960L	Substitution - Missense	Skin
COSM335729	c.68A>C	p.Q23P	Substitution - Missense	Lung
COSM3832538	c.2309T>G	p.V770G	Substitution - Missense	Breast
COSM3637534	c.451C>T	p.P151S	Substitution - Missense	Skin
COSM3026306	c.1639G>A	p.A547T	Substitution - Missense	Large_intestine
COSM3394691	c.2116C>T	p.L706F	Substitution - Missense	Pancreas
COSM3637560	c.2483C>T	p.S828L	Substitution - Missense	Skin
COSM3923406	c.844G>A	p.E282K	Substitution - Missense	Skin
COSM3026300	c.1490A>C	p.K497T	Substitution - Missense	Large_intestine
COSM233509	c.1092G>A	p.M364I	Substitution - Missense	Skin
COSM3374596	c.1133+1G>A	p.?	Unknown	Thyroid
COSM4529814	c.1644G>A	p.M548I	Substitution - Missense	Skin
COSM5746703	c.2053_2054delGA	p.E687fs*3	Deletion - Frameshift	Pancreas
COSM1088613	c.91G>A	p.D31N	Substitution - Missense	Endometrium
COSM3728604	c.2157T>C	p.G719G	Substitution - coding silent	Stomach
COSM3637566	c.2807C>T	p.P936L	Substitution - Missense	Skin
COSM238253	c.1713+9C>T	p.?	Unknown	Prostate
COSM1698421	c.1076A>G	p.Y359C	Substitution - Missense	Skin
COSM3366676	c.2005G>T	p.E669*	Substitution - Nonsense	Kidney
COSM3637551	c.2091G>A	p.Q697Q	Substitution - coding silent	Skin
COSM746389	c.203T>A	p.V68D	Substitution - Missense	Lung
COSM5778789	c.1965+3A>C	p.?	Unknown	Breast
COSM1088652	c.2182C>T	p.R728*	Substitution - Nonsense	Endometrium
COSM1698420	c.730G>A	p.G244R	Substitution - Missense	Skin
COSM1450086	c.2761-1G>A	p.?	Unknown	Skin
COSM5987248	c.1745C>T	p.S582L	Substitution - Missense	Salivary_gland
COSM5781496	c.480T>A	p.D160E	Substitution - Missense	Breast
COSM4558491	c.769G>A	p.G257R	Substitution - Missense	Skin
COSM4395086	c.20C>T	p.S7F	Substitution - Missense	Skin
COSM3637552	c.2163C>T	p.L721L	Substitution - coding silent	Skin
COSM746388	c.279G>T	p.Q93H	Substitution - Missense	Lung
COSM4419685	c.69A>G	p.Q23Q	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM150251	c.1417-10C>A	p.?	Unknown	Stomach
COSM746379	c.1509T>G	p.C503W	Substitution - Missense	Lung
COSM1698423	c.1975C>T	p.P659S	Substitution - Missense	Skin
COSM1312983	c.1993G>C	p.E665Q	Substitution - Missense	Urinary_tract
COSM1243644	c.2550A>G	p.I850M	Substitution - Missense	Oesophagus
COSM3637568	c.2968A>G	p.T990A	Substitution - Missense	Skin
COSM12927	c.2050C>T	p.H684Y	Substitution - Missense	Skin
COSM1450079	c.1486A>T	p.K496*	Substitution - Nonsense	Large_intestine
COSM1088654	c.2277C>T	p.G759G	Substitution - coding silent	Endometrium
COSM5723872	c.948G>A	p.E316E	Substitution - coding silent	Skin
COSM3723732	c.2328C>G	p.T776T	Substitution - coding silent	Upper_aerodigestive_tract
COSM3637535	c.507G>A	p.L169L	Substitution - coding silent	Skin
COSM4388390	c.1279A>G	p.T427A	Substitution - Missense	Pancreas
COSM5663510	c.1426G>T	p.V476F	Substitution - Missense	Soft_tissue
COSM3026278	c.580T>G	p.Y194D	Substitution - Missense	Large_intestine
COSM3026307	c.1713+10G>A	p.?	Unknown	Large_intestine
COSM3880293	c.33C>T	p.S11S	Substitution - coding silent	Stomach
COSM3880294	c.61A>T	p.I21F	Substitution - Missense	Stomach
COSM299530	c.1833+7T>A	p.?	Unknown	Large_intestine
COSM3880299	c.2875A>C	p.S959R	Substitution - Missense	Stomach
COSM4164268	c.968G>A	p.S323N	Substitution - Missense	Ovary
COSM3637552	c.2163C>T	p.L721L	Substitution - coding silent	Skin
COSM600550	c.2324C>T	p.A775V	Substitution - Missense	Liver
COSM3736439	c.1863T>G	p.N621K	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3923410	c.1662C>T	p.I554I	Substitution - coding silent	Skin
COSM3880296	c.1870C>T	p.P624S	Substitution - Missense	Stomach
COSM452878	c.2505G>T	p.M835I	Substitution - Missense	Breast
COSM263892	c.1960G>A	p.E654K	Substitution - Missense	Large_intestine
COSM1242892	c.668delA	p.K225fs*35	Deletion - Frameshift	Large_intestine
COSM3637567	c.2950G>A	p.E984K	Substitution - Missense	Skin
COSM3637556	c.2231C>T	p.P744L	Substitution - Missense	Skin
COSM3698041	c.324+1G>A	p.?	Unknown	Large_intestine
COSM233509	c.1092G>A	p.M364I	Substitution - Missense	Skin
COSM3637553	c.2172G>A	p.M724I	Substitution - Missense	Skin
COSM3923405	c.514G>A	p.E172K	Substitution - Missense	Skin
COSM381066	c.2692G>C	p.E898Q	Substitution - Missense	Lung
COSM5407250	c.601G>A	p.E201K	Substitution - Missense	Skin
COSM3637558	c.2407C>T	p.P803S	Substitution - Missense	Skin
COSM3637563	c.2657A>G	p.N886S	Substitution - Missense	Skin
COSM1698422	c.1645G>A	p.D549N	Substitution - Missense	Skin
COSM3026334	c.3032G>A	p.R1011K	Substitution - Missense	Skin
COSM12927	c.2050C>T	p.H684Y	Substitution - Missense	Lung
COSM4535395	c.2185G>C	p.D729H	Substitution - Missense	Skin
COSM3026265	c.40G>T	p.E14*	Substitution - Nonsense	Stomach
COSM1698418	c.391C>T	p.P131S	Substitution - Missense	Skin
COSM1088644	c.1888C>A	p.L630I	Substitution - Missense	Endometrium
COSM5407253	c.1578G>A	p.W526*	Substitution - Nonsense	Skin
COSM3637546	c.1686C>T	p.V562V	Substitution - coding silent	Skin
COSM3411944	c.2597A>G	p.E866G	Substitution - Missense	Central_nervous_system
COSM4616643	c.2546A>G	p.D849G	Substitution - Missense	Large_intestine
COSM1720580	c.902A>G	p.K301R	Substitution - Missense	Skin
COSM3637557	c.2331C>T	p.Y777Y	Substitution - coding silent	Skin
COSM3778336	c.1759C>T	p.Q587*	Substitution - Nonsense	Urinary_tract
COSM3637545	c.1666G>A	p.E556K	Substitution - Missense	Skin
COSM3637550	c.1952G>A	p.S651N	Substitution - Missense	Skin
COSM3637541	c.1477G>A	p.E493K	Substitution - Missense	Skin
COSM1488483	c.2593C>T	p.R865C	Substitution - Missense	Breast
COSM485217	c.668A>T	p.E223V	Substitution - Missense	Kidney
COSM3637562	c.2488G>A	p.E830K	Substitution - Missense	Skin
COSM1698426	c.2188C>T	p.L730F	Substitution - Missense	Skin
COSM1242892	c.668delA	p.K225fs*35	Deletion - Frameshift	Oesophagus
COSM5821320	c.2430A>T	p.P810P	Substitution - coding silent	Liver
COSM1242892	c.668delA	p.K225fs*35	Deletion - Frameshift	Biliary_tract
COSM1088660	c.2883G>T	p.M961I	Substitution - Missense	Endometrium
COSM1622715	c.777A>T	p.L259F	Substitution - Missense	Liver
COSM3637542	c.1517G>A	p.R506K	Substitution - Missense	Skin
COSM5626941	c.1558C>G	p.L520V	Substitution - Missense	Oesophagus
COSM3394690	c.231G>T	p.G77G	Substitution - coding silent	Pancreas
COSM5407255	c.2633C>T	p.S878F	Substitution - Missense	Skin
COSM233509	c.1092G>A	p.M364I	Substitution - Missense	Skin
COSM226595	c.814G>A	p.D272N	Substitution - Missense	Skin
COSM3736440	c.1868G>T	p.S623I	Substitution - Missense	Large_intestine
COSM3736439	c.1863T>G	p.N621K	Substitution - Missense	Skin
COSM1088628	c.1134G>A	p.R378R	Substitution - coding silent	Endometrium
COSM3637536	c.702G>A	p.R234R	Substitution - coding silent	Skin
COSM1088652	c.2182C>T	p.R728*	Substitution - Nonsense	Central_nervous_system
COSM3950357	c.1371G>C	p.L457L	Substitution - coding silent	Lung
COSM3736437	c.781G>A	p.E261K	Substitution - Missense	Large_intestine
COSM4522481	c.1165G>A	p.D389N	Substitution - Missense	Skin
COSM485219	c.2412G>A	p.M804I	Substitution - Missense	Kidney
COSM1241790	c.2456C>T	p.A819V	Substitution - Missense	Oesophagus
COSM1088618	c.559A>G	p.T187A	Substitution - Missense	Endometrium
COSM1088613	c.91G>A	p.D31N	Substitution - Missense	Endometrium
COSM5723872	c.948G>A	p.E316E	Substitution - coding silent	Skin
COSM1088626	c.1034C>A	p.A345D	Substitution - Missense	Endometrium
COSM1088615	c.463G>T	p.E155*	Substitution - Nonsense	Endometrium
COSM1242892	c.668delA	p.K225fs*35	Deletion - Frameshift	Large_intestine
COSM1088638	c.1586G>T	p.R529I	Substitution - Missense	Endometrium
COSM3637532	c.350G>A	p.G117E	Substitution - Missense	Skin
COSM3923409	c.1606C>T	p.L536L	Substitution - coding silent	Skin
COSM323642	c.1577G>T	p.W526L	Substitution - Missense	Lung
COSM3637555	c.2212G>A	p.E738K	Substitution - Missense	Skin
COSM1450078	c.1405A>C	p.K469Q	Substitution - Missense	Large_intestine
COSM4556078	c.678G>A	p.L226L	Substitution - coding silent	Skin
COSM346896	c.536T>G	p.I179S	Substitution - Missense	Lung
COSM746384	c.860G>A	p.G287D	Substitution - Missense	Lung
COSM5358342	c.2804T>C	p.I935T	Substitution - Missense	Large_intestine
COSM3637538	c.1004C>T	p.A335V	Substitution - Missense	Skin
COSM3923407	c.1051C>T	p.H351Y	Substitution - Missense	Skin
COSM12927	c.2050C>T	p.H684Y	Substitution - Missense	Lung
COSM1686020	c.2179G>A	p.E727K	Substitution - Missense	Skin
COSM3637548	c.1717C>T	p.Q573*	Substitution - Nonsense	Skin
COSM4730572	c.2549T>C	p.I850T	Substitution - Missense	Large_intestine
COSM5031232	c.2594G>A	p.R865H	Substitution - Missense	Pancreas
COSM323643	c.1612G>T	p.V538L	Substitution - Missense	Lung
COSM4730573	c.3003G>T	p.E1001D	Substitution - Missense	Large_intestine
COSM1088654	c.2277C>T	p.G759G	Substitution - coding silent	Large_intestine
COSM1227873	c.2259G>T	p.Q753H	Substitution - Missense	Large_intestine
COSM1088620	c.630G>T	p.E210D	Substitution - Missense	Endometrium
COSM4541006	c.2929G>A	p.E977K	Substitution - Missense	Skin
COSM5623541	c.2279A>G	p.Y760C	Substitution - Missense	Oesophagus
COSM3923413	c.2566C>T	p.H856Y	Substitution - Missense	Skin
COSM5013911	c.2608G>A	p.V870I	Substitution - Missense	Kidney
COSM1227875	c.2183G>A	p.R728Q	Substitution - Missense	Skin
COSM265861	c.1524G>C	p.E508D	Substitution - Missense	Large_intestine
COSM3928980	c.3018T>A	p.C1006*	Substitution - Nonsense	Central_nervous_system
COSM1720580	c.902A>G	p.K301R	Substitution - Missense	Skin
COSM1242892	c.668delA	p.K225fs*35	Deletion - Frameshift	Skin
COSM3637532	c.350G>A	p.G117E	Substitution - Missense	Skin
COSM3832539	c.2535G>T	p.L845F	Substitution - Missense	Breast
COSM4730574	c.3027G>T	p.K1009N	Substitution - Missense	Large_intestine
COSM746378	c.2827C>G	p.L943V	Substitution - Missense	Lung
COSM3637570	c.3047A>G	p.N1016S	Substitution - Missense	Skin
COSM1673058	c.1741A>C	p.I581L	Substitution - Missense	Large_intestine
COSM1159236	c.1900A>G	p.K634E	Substitution - Missense	Pancreas
COSM1088642	c.1850T>C	p.I617T	Substitution - Missense	Endometrium
COSM421492	c.1767G>T	p.L589L	Substitution - coding silent	Urinary_tract
COSM3762594	c.213G>C	p.Q71H	Substitution - Missense	Large_intestine
COSM3394690	c.231G>T	p.G77G	Substitution - coding silent	Pancreas
COSM5018500	c.2070G>A	p.E690E	Substitution - coding silent	Soft_tissue
COSM1312982	c.1300G>A	p.G434R	Substitution - Missense	Urinary_tract
COSM3736439	c.1863T>G	p.N621K	Substitution - Missense	Pancreas
COSM1664381	c.1963G>C	p.E655Q	Substitution - Missense	Kidney
COSM3637561	c.2485G>A	p.E829K	Substitution - Missense	Skin
COSM258104	c.2873G>C	p.R958T	Substitution - Missense	Large_intestine
COSM3411945	c.2644C>T	p.R882*	Substitution - Nonsense	Central_nervous_system
COSM1088656	c.2320G>A	p.A774T	Substitution - Missense	Endometrium
COSM5660154	c.2227C>A	p.R743S	Substitution - Missense	Soft_tissue
COSM21124	c.2578G>T	p.V860L	Substitution - Missense	Lung
COSM5932152	c.1245G>A	p.W415*	Substitution - Nonsense	Skin
COSM1755223	c.1708C>T	p.L570L	Substitution - coding silent	Urinary_tract
COSM394047	c.1163A>G	p.K388R	Substitution - Missense	Lung
COSM1450085	c.2719C>T	p.P907S	Substitution - Missense	Large_intestine
COSM1686531	c.2068-1G>A	p.?	Unknown	Skin
COSM1088652	c.2182C>T	p.R728*	Substitution - Nonsense	Central_nervous_system
COSM3637554	c.2198C>T	p.A733V	Substitution - Missense	Skin
COSM76620	c.548C>G	p.S183C	Substitution - Missense	Ovary
COSM3026293	c.1254C>A	p.Y418*	Substitution - Nonsense	Pancreas
COSM5447756	c.1243T>C	p.W415R	Substitution - Missense	Large_intestine
COSM12927	c.2050C>T	p.H684Y	Substitution - Missense	Skin
COSM1643316	c.1457_1459delAAG	p.E487delE	Deletion - In frame	Stomach
COSM1088636	c.1434A>G	p.L478L	Substitution - coding silent	Endometrium
COSM5554611	c.485G>C	p.G162A	Substitution - Missense	Prostate
COSM1582718	c.344A>G	p.D115G	Substitution - Missense	Stomach
COSM4730571	c.1489A>C	p.K497Q	Substitution - Missense	Large_intestine
COSM3768326	c.291A>G	p.R97R	Substitution - coding silent	Liver
COSM21124	c.2578G>T	p.V860L	Substitution - Missense	Lung
COSM1227876	c.2791A>C	p.N931H	Substitution - Missense	Large_intestine
COSM4484741	c.2847C>T	p.S949S	Substitution - coding silent	Skin
COSM3026275	c.370C>T	p.R124*	Substitution - Nonsense	Large_intestine
COSM3637569	c.3040G>A	p.E1014K	Substitution - Missense	Skin
COSM1450072	c.118C>G	p.H40D	Substitution - Missense	Large_intestine
COSM1242892	c.668delA	p.K225fs*35	Deletion - Frameshift	Large_intestine
COSM5817640	c.127G>T	p.D43Y	Substitution - Missense	Liver
COSM4394233	c.2327C>T	p.T776I	Substitution - Missense	Skin
COSM1088634	c.1360G>T	p.D454Y	Substitution - Missense	Endometrium
COSM3762594	c.213G>C	p.Q71H	Substitution - Missense	Pancreas
COSM4004435	c.1229G>A	p.G410E	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1227875	c.2183G>A	p.R728Q	Substitution - Missense	Large_intestine
COSM1088630	c.1141G>A	p.D381N	Substitution - Missense	Large_intestine
COSM3637537	c.722C>T	p.P241L	Substitution - Missense	Skin
COSM1088648	c.2043A>C	p.E681D	Substitution - Missense	Endometrium
COSM3637541	c.1477G>A	p.E493K	Substitution - Missense	Skin
COSM1088640	c.1773G>T	p.K591N	Substitution - Missense	Endometrium
COSM3832540	c.3052G>C	p.D1018H	Substitution - Missense	Breast
COSM3736440	c.1868G>T	p.S623I	Substitution - Missense	Skin
COSM5656881	c.876G>T	p.G292G	Substitution - coding silent	Soft_tissue
COSM4004435	c.1229G>A	p.G410E	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1088630	c.1141G>A	p.D381N	Substitution - Missense	Breast
COSM5407256	c.2682G>A	p.L894L	Substitution - coding silent	Skin
COSM1755223	c.1708C>T	p.L570L	Substitution - coding silent	Urinary_tract
COSM1088630	c.1141G>A	p.D381N	Substitution - Missense	Endometrium
COSM746390	c.151-2A>G	p.?	Unknown	Lung
COSM1730221	c.2149-1G>T	p.?	Unknown	Liver
COSM1088646	c.1899G>T	p.K633N	Substitution - Missense	Endometrium
COSM3663115	c.2729A>T	p.D910V	Substitution - Missense	Liver
COSM5802594	c.794_795delTT	p.L265fs*5	Deletion - Frameshift	Breast
COSM3880292	c.33C>G	p.S11S	Substitution - coding silent	Stomach
COSM4924783	c.269C>T	p.S90F	Substitution - Missense	Liver
COSM452876	c.1622C>T	p.S541L	Substitution - Missense	Breast
COSM4401043	c.1401C>T	p.R467R	Substitution - coding silent	Skin
COSM3950358	c.1372G>T	p.E458*	Substitution - Nonsense	Lung
COSM121965	c.135A>T	p.V45V	Substitution - coding silent	Upper_aerodigestive_tract
COSM4587330	c.2863A>T	p.I955L	Substitution - Missense	Bone
COSM1227874	c.1760A>G	p.Q587R	Substitution - Missense	Large_intestine
COSM1450086	c.2761-1G>A	p.?	Unknown	Large_intestine
COSM3431514	c.135A>C	p.V45V	Substitution - coding silent	Large_intestine
COSM1088613	c.91G>A	p.D31N	Substitution - Missense	Endometrium
COSM3880295	c.1638C>T	p.D546D	Substitution - coding silent	Stomach
COSM1635255	c.86A>C	p.H29P	Substitution - Missense	Liver
COSM4626000	c.855T>A	p.A285A	Substitution - coding silent	Large_intestine
COSM485218	c.1399C>T	p.R467C	Substitution - Missense	Large_intestine
COSM3431515	c.174C>A	p.I58I	Substitution - coding silent	Large_intestine
COSM3637543	c.1581C>T	p.F527F	Substitution - coding silent	Skin
COSM5457325	c.1292T>C	p.V431A	Substitution - Missense	Large_intestine
COSM1088652	c.2182C>T	p.R728*	Substitution - Nonsense	Stomach
COSM346896	c.536T>G	p.I179S	Substitution - Missense	Endometrium
COSM1622716	c.977C>T	p.A326V	Substitution - Missense	Liver
COSM3736439	c.1863T>G	p.N621K	Substitution - Missense	Large_intestine
COSM1329893	c.1228G>T	p.G410*	Substitution - Nonsense	Ovary
COSM5407257	c.2690C>T	p.P897L	Substitution - Missense	Skin
COSM1739318	c.1713+1G>T	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM4538488	c.2558G>A	p.G853E	Substitution - Missense	Skin
COSM1673057	c.1688G>C	p.C563S	Substitution - Missense	Prostate
COSM3762594	c.213G>C	p.Q71H	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1266934	c.1031C>A	p.A344D	Substitution - Missense	Oesophagus
COSM452875	c.290G>A	p.R97K	Substitution - Missense	Breast
COSM3736438	c.804G>T	p.K268N	Substitution - Missense	Large_intestine
COSM107550	c.2647G>A	p.A883T	Substitution - Missense	Skin
COSM4654235	c.2170A>G	p.M724V	Substitution - Missense	Large_intestine
COSM4844906	c.2314G>A	p.E772K	Substitution - Missense	Cervix
COSM746377	c.3026A>T	p.K1009M	Substitution - Missense	Lung
COSM3394690	c.231G>T	p.G77G	Substitution - coding silent	Pancreas
COSM3366677	c.2531C>G	p.T844R	Substitution - Missense	Kidney
COSM3026298	c.1452A>C	p.Q484H	Substitution - Missense	Large_intestine
COSM4902902	c.1833+2T>C	p.?	Unknown	Skin
COSM5407258	c.2820G>A	p.Q940Q	Substitution - coding silent	Skin
COSM746383	c.1071G>T	p.K357N	Substitution - Missense	Lung
COSM3880298	c.2277C>A	p.G759G	Substitution - coding silent	Stomach
COSM1568458	c.1401C>G	p.R467R	Substitution - coding silent	Large_intestine
COSM3784069	c.2475T>A	p.P825P	Substitution - coding silent	Prostate
COSM3637564	c.2728G>A	p.D910N	Substitution - Missense	Skin
COSM3637547	c.1714G>A	p.D572N	Substitution - Missense	Skin
COSM1227877	c.2916C>A	p.F972L	Substitution - Missense	Large_intestine
COSM746387	c.722C>A	p.P241H	Substitution - Missense	Lung
COSM3026275	c.370C>T	p.R124*	Substitution - Nonsense	Skin
COSM5723872	c.948G>A	p.E316E	Substitution - coding silent	Skin
COSM235444	c.2451G>A	p.L817L	Substitution - coding silent	Skin
COSM3637565	c.2800G>A	p.G934R	Substitution - Missense	Skin
COSM3880297	c.1879G>A	p.D627N	Substitution - Missense	Stomach
COSM5710503	c.2204C>A	p.P735H	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4569841	c.2098T>C	p.F700L	Substitution - Missense	Skin
COSM746381	c.1214C>A	p.P405Q	Substitution - Missense	Lung
COSM5512370	c.1552G>A	p.A518T	Substitution - Missense	Biliary_tract
COSM1450075	c.343G>T	p.D115Y	Substitution - Missense	Large_intestine
COSM3880298	c.2277C>A	p.G759G	Substitution - coding silent	Large_intestine
COSM746386	c.726G>T	p.L242F	Substitution - Missense	Lung
COSM3736437	c.781G>A	p.E261K	Substitution - Missense	Skin
COSM164653	c.2536C>T	p.H846Y	Substitution - Missense	Breast
COSM1088615	c.463G>T	p.E155*	Substitution - Nonsense	Endometrium
COSM5423372	c.1906T>C	p.L636L	Substitution - coding silent	Prostate
COSM99016	c.2831A>G	p.D944G	Substitution - Missense	Stomach
COSM5407252	c.1169T>G	p.L390R	Substitution - Missense	Skin
COSM1450077	c.1404delA	p.T470fs*9	Deletion - Frameshift	Large_intestine
COSM1732563	c.552A>C	p.E184D	Substitution - Missense	Soft_tissue
COSM352215	c.2692G>T	p.E898*	Substitution - Nonsense	Lung
COSM1673058	c.1741A>C	p.I581L	Substitution - Missense	Large_intestine
COSM1622715	c.777A>T	p.L259F	Substitution - Missense	Liver
COSM3637534	c.451C>T	p.P151S	Substitution - Missense	Cervix
COSM382454	c.762G>T	p.R254S	Substitution - Missense	Lung

> Text Mining based Variations

PMID	Variation	Cancer	Evidence
21097718	Mutation	Gastric Carcinoma	When applied to primary GCs, we identified somatic mutations in 8 kinases, 4 of which were recurrently altered in both primary tumors and cell lines (MAP3K6, STK31, FER, and CDKL5).
24755198	Mutation	Melanoma	Third, we identified 12 significantly mutated genes in pan-negative samples (ALK, STK31, DGKI, RAC1, EPHA4, ADAMTS18, EPHA7, ERBB4, TAF1L, NF1, SYK, and KDR), including five genes (RAC1, ADAMTS18, EPHA7, TAF1L, and NF1) with a recurrent mutation in at least two pan-negative tumor samples.

Summary
Symbol	STK31
Name	serine/threonine kinase 31
Aliases	TDRD8; SgK396; serine/threonine-protein kinase NYD-SPK; sugen kinase 396; tudor domain containing 8; Serine/ ......
Location	7p15.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM) [ TOP ]
There is no PTM data

Summary
Symbol	STK31
Name	serine/threonine kinase 31
Aliases	TDRD8; SgK396; serine/threonine-protein kinase NYD-SPK; sugen kinase 396; tudor domain containing 8; Serine/ ......
Location	7p15.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	-2.81	0.322	3.013	1.41e-08	Over
BRCA	Breast invasive carcinoma	112	1100	-3.066	-2.993	0.455	0.0428	NS
CESC	Cervical and endocervical cancers	3	306	-3.293	-0.449	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	-2.919	0.777	3.693	8.22e-31	Over
ESCA	Esophageal carcinoma	11	185	-1.416	1.57	2.891	0.000276	Over
HNSC	Head and Neck squamous cell carcinoma	44	522	-1.821	0.085	1.958	1.76e-07	Over
LUAD	Lung adenocarcinoma	59	517	-0.29	1.552	1.73	4.15e-12	Over
LUSC	Lung squamous cell carcinoma	51	501	-0.339	1.329	1.566	7.75e-12	Over
OV	Ovarian serous cystadenocarcinoma	0	307	NA	-1.337	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	-1.706	0.371	NA	NA	NA
READ	Rectum adenocarcinoma	10	167	-3.724	0.937	4.133	5.68e-10	Over
SARC	Sarcoma	2	263	-5.251	-3.832	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	-6.834	-4.973	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	-2.904	0.887	3.751	3.42e-15	Over
TGCT	Testicular Germ Cell Tumors	0	156	NA	2.442	NA	NA	NA
THYM	Thymoma	2	120	-1.089	-2.024	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	-2.606	-0.583	2.181	1.12e-10	Over

> Cancer Cell Line Encyclopedia (CCLE)

Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	3.7
Autonomic ganglia	CHP212	3.7
Autonomic ganglia	IMR32	4
Autonomic ganglia	KELLY	3.7
Autonomic ganglia	KPNRTBM1	4.3
Autonomic ganglia	KPNSI9S	4.7
Autonomic ganglia	KPNYN	3.8
Autonomic ganglia	MHHNB11	4.4
Autonomic ganglia	NB1	4.3
Autonomic ganglia	NH6	4.2
Autonomic ganglia	SHSY5Y	3.8
Autonomic ganglia	SIMA	3.7
Autonomic ganglia	SKNAS	4.1
Autonomic ganglia	SKNBE2	3.9
Autonomic ganglia	SKNDZ	4.2
Autonomic ganglia	SKNFI	3.7
Autonomic ganglia	SKNSH	3.9
Biliary tract	HUCCT1	4.2
Biliary tract	HUH28	4.3
Biliary tract	SNU1079	4.2
Biliary tract	SNU1196	4
Biliary tract	SNU245	5.8
Biliary tract	SNU308	6.1
Biliary tract	SNU478	4.7
Bone	143B	3.6
Bone	A673	4
Bone	CADOES1	3.8
Bone	CAL78	4.4
Bone	G292CLONEA141B1	4
Bone	HOS	4
Bone	HS706T	3.9
Bone	HS737T	3.6
Bone	HS819T	3.7
Bone	HS821T	3.5
Bone	HS822T	3.9
Bone	HS863T	3.8
Bone	HS870T	4.2
Bone	HS888T	3.7
Bone	MG63	3.9
Bone	MHHES1	3.6
Bone	OUMS27	4.2
Bone	RDES	4.2
Bone	SJSA1	4
Bone	SKES1	5.2
Bone	SKNMC	4
Bone	SW1353	4
Bone	T173	3.7
Bone	TC71	4.1
Bone	U2OS	4
Breast	AU565	4.4
Breast	BT20	3.7
Breast	BT474	4
Breast	BT483	5.4
Breast	BT549	3.8
Breast	CAL120	3.5
Breast	CAL148	4.2
Breast	CAL51	3.8
Breast	CAL851	3.8
Breast	CAMA1	4
Breast	DU4475	5
Breast	EFM192A	4
Breast	EFM19	4.6
Breast	EVSAT	3.6
Breast	HCC1143	3.7
Breast	HCC1187	4
Breast	HCC1395	4.1
Breast	HCC1419	3.7
Breast	HCC1428	4.3
Breast	HCC1500	4.1
Breast	HCC1569	4
Breast	HCC1599	3.7
Breast	HCC1806	4.6
Breast	HCC1937	5.4
Breast	HCC1954	4
Breast	HCC202	3.9
Breast	HCC2157	4.2
Breast	HCC2218	4.3
Breast	HCC38	3.8
Breast	HCC70	3.8
Breast	HDQP1	8.2
Breast	HMC18	4.1
Breast	HS274T	3.8
Breast	HS281T	3.8
Breast	HS343T	3.7
Breast	HS578T	3.8
Breast	HS606T	3.8
Breast	HS739T	3.7
Breast	HS742T	3.7
Breast	JIMT1	3.7
Breast	KPL1	3.8
Breast	MCF7	4
Breast	MDAMB134VI	3.8
Breast	MDAMB157	4.5
Breast	MDAMB175VII	4
Breast	MDAMB231	4.1
Breast	MDAMB361	3.7
Breast	MDAMB415	3.8
Breast	MDAMB436	3.8
Breast	MDAMB453	4.1
Breast	MDAMB468	4
Breast	SKBR3	5
Breast	T47D	4.1
Breast	UACC812	4
Breast	UACC893	4
Breast	YMB1	3.9
Breast	ZR751	4.4
Breast	ZR7530	3.8
Central nervous system	1321N1	3.9
Central nervous system	42MGBA	4
Central nervous system	8MGBA	4
Central nervous system	A172	3.7
Central nervous system	AM38	3.8
Central nervous system	BECKER	3.9
Central nervous system	CAS1	3.9
Central nervous system	CCFSTTG1	3.7
Central nervous system	D283MED	4
Central nervous system	D341MED	3.7
Central nervous system	DAOY	3.9
Central nervous system	DBTRG05MG	4.7
Central nervous system	DKMG	4.1
Central nervous system	GAMG	3.7
Central nervous system	GB1	3.7
Central nervous system	GI1	4.2
Central nervous system	GMS10	3.9
Central nervous system	GOS3	4.1
Central nervous system	H4	3.8
Central nervous system	HS683	4.3
Central nervous system	KALS1	3.8
Central nervous system	KG1C	4
Central nervous system	KNS42	3.7
Central nervous system	KNS60	4
Central nervous system	KNS81	4.3
Central nervous system	KS1	4
Central nervous system	LN18	4.3
Central nervous system	LN229	3.9
Central nervous system	M059K	3.7
Central nervous system	MOGGCCM	3.6
Central nervous system	MOGGUVW	4.5
Central nervous system	NMCG1	3.7
Central nervous system	ONS76	3.7
Central nervous system	SF126	3.8
Central nervous system	SF295	3.7
Central nervous system	SNB19	3.9
Central nervous system	SNU1105	3.7
Central nervous system	SNU201	4.1
Central nervous system	SNU466	3.9
Central nervous system	SNU489	3.6
Central nervous system	SNU626	4
Central nervous system	SNU738	4
Central nervous system	SW1088	3.9
Central nervous system	SW1783	3.7
Central nervous system	T98G	3.9
Central nervous system	TM31	3.9
Central nervous system	U118MG	3.6
Central nervous system	U138MG	3.6
Central nervous system	U251MG	3.9
Central nervous system	U87MG	3.9
Central nervous system	YH13	4
Central nervous system	YKG1	4
Endometrium	AN3CA	4.5
Endometrium	COLO684	3.9
Endometrium	EFE184	5.3
Endometrium	EN	3.7
Endometrium	ESS1	4.1
Endometrium	HEC108	4.9
Endometrium	HEC151	4.2
Endometrium	HEC1A	3.9
Endometrium	HEC1B	3.9
Endometrium	HEC251	7.3
Endometrium	HEC265	4
Endometrium	HEC50B	4
Endometrium	HEC59	4.7
Endometrium	HEC6	3.9
Endometrium	ISHIKAWAHERAKLIO02ER	7.7
Endometrium	JHUEM1	7.2
Endometrium	JHUEM2	3.7
Endometrium	JHUEM3	3.8
Endometrium	KLE	4
Endometrium	MFE280	3.9
Endometrium	MFE296	4.1
Endometrium	MFE319	4.4
Endometrium	RL952	3.7
Endometrium	SNGM	3.7
Endometrium	SNU1077	5
Endometrium	SNU685	3.6
Endometrium	TEN	4.2
Haematopoietic and lymphoid	697	4.1
Haematopoietic and lymphoid	A3KAW	3.7
Haematopoietic and lymphoid	A4FUK	4.2
Haematopoietic and lymphoid	ALLSIL	3.9
Haematopoietic and lymphoid	AML193	4.2
Haematopoietic and lymphoid	AMO1	3.7
Haematopoietic and lymphoid	BCP1	4.3
Haematopoietic and lymphoid	BDCM	4
Haematopoietic and lymphoid	BL41	3.4
Haematopoietic and lymphoid	BL70	4
Haematopoietic and lymphoid	BV173	3.9
Haematopoietic and lymphoid	CA46	3.9
Haematopoietic and lymphoid	CI1	4
Haematopoietic and lymphoid	CMK115	4
Haematopoietic and lymphoid	CMK86	3.8
Haematopoietic and lymphoid	CMK	3.8
Haematopoietic and lymphoid	CMLT1	4.1
Haematopoietic and lymphoid	COLO775	3.7
Haematopoietic and lymphoid	DAUDI	3.9
Haematopoietic and lymphoid	DB	4.1
Haematopoietic and lymphoid	DEL	3.7
Haematopoietic and lymphoid	DND41	3.9
Haematopoietic and lymphoid	DOHH2	3.9
Haematopoietic and lymphoid	EB1	4.3
Haematopoietic and lymphoid	EB2	3.9
Haematopoietic and lymphoid	EHEB	3.7
Haematopoietic and lymphoid	EJM	3.7
Haematopoietic and lymphoid	EM2	3.7
Haematopoietic and lymphoid	EOL1	3.8
Haematopoietic and lymphoid	F36P	4.1
Haematopoietic and lymphoid	GA10	4.5
Haematopoietic and lymphoid	GDM1	4.2
Haematopoietic and lymphoid	GRANTA519	3.5
Haematopoietic and lymphoid	HDLM2	3.9
Haematopoietic and lymphoid	HDMYZ	3.7
Haematopoietic and lymphoid	HEL9217	4.1
Haematopoietic and lymphoid	HEL	4.2
Haematopoietic and lymphoid	HH	4.3
Haematopoietic and lymphoid	HL60	4.3
Haematopoietic and lymphoid	HPBALL	4.2
Haematopoietic and lymphoid	HS604T	3.9
Haematopoietic and lymphoid	HS611T	3.8
Haematopoietic and lymphoid	HS616T	3.8
Haematopoietic and lymphoid	HS751T	4.1
Haematopoietic and lymphoid	HT	4.1
Haematopoietic and lymphoid	HTK	3.5
Haematopoietic and lymphoid	HUNS1	4.5
Haematopoietic and lymphoid	HUT102	4
Haematopoietic and lymphoid	HUT78	3.9
Haematopoietic and lymphoid	JEKO1	3.9
Haematopoietic and lymphoid	JK1	4.1
Haematopoietic and lymphoid	JM1	4.2
Haematopoietic and lymphoid	JURKAT	3.9
Haematopoietic and lymphoid	JURLMK1	4.1
Haematopoietic and lymphoid	JVM2	3.6
Haematopoietic and lymphoid	JVM3	4.1
Haematopoietic and lymphoid	K562	4.5
Haematopoietic and lymphoid	KARPAS299	4
Haematopoietic and lymphoid	KARPAS422	3.8
Haematopoietic and lymphoid	KARPAS620	3.8
Haematopoietic and lymphoid	KASUMI1	3.9
Haematopoietic and lymphoid	KASUMI2	3.9
Haematopoietic and lymphoid	KASUMI6	3.9
Haematopoietic and lymphoid	KCL22	3.6
Haematopoietic and lymphoid	KE37	4.5
Haematopoietic and lymphoid	KE97	8.8
Haematopoietic and lymphoid	KG1	3.7
Haematopoietic and lymphoid	KHM1B	4
Haematopoietic and lymphoid	KIJK	4
Haematopoietic and lymphoid	KMH2	3.8
Haematopoietic and lymphoid	KMM1	9.3
Haematopoietic and lymphoid	KMS11	4.1
Haematopoietic and lymphoid	KMS12BM	3.9
Haematopoietic and lymphoid	KMS18	7.9
Haematopoietic and lymphoid	KMS20	4.2
Haematopoietic and lymphoid	KMS21BM	3.8
Haematopoietic and lymphoid	KMS26	4.3
Haematopoietic and lymphoid	KMS27	3.8
Haematopoietic and lymphoid	KMS28BM	4.1
Haematopoietic and lymphoid	KMS34	3.7
Haematopoietic and lymphoid	KO52	3.9
Haematopoietic and lymphoid	KOPN8	3.6
Haematopoietic and lymphoid	KU812	4.1
Haematopoietic and lymphoid	KYO1	3.9
Haematopoietic and lymphoid	L1236	4.2
Haematopoietic and lymphoid	L363	4.1
Haematopoietic and lymphoid	L428	3.9
Haematopoietic and lymphoid	L540	3.8
Haematopoietic and lymphoid	LAMA84	3.7
Haematopoietic and lymphoid	LOUCY	4.2
Haematopoietic and lymphoid	LP1	3.8
Haematopoietic and lymphoid	M07E	3.9
Haematopoietic and lymphoid	MC116	4.1
Haematopoietic and lymphoid	ME1	3.7
Haematopoietic and lymphoid	MEC1	3.6
Haematopoietic and lymphoid	MEC2	3.8
Haematopoietic and lymphoid	MEG01	3.7
Haematopoietic and lymphoid	MHHCALL2	4
Haematopoietic and lymphoid	MHHCALL3	4.1
Haematopoietic and lymphoid	MHHCALL4	3.8
Haematopoietic and lymphoid	MINO	3.9
Haematopoietic and lymphoid	MJ	3.8
Haematopoietic and lymphoid	MM1S	3.7
Haematopoietic and lymphoid	MOLM13	3.9
Haematopoietic and lymphoid	MOLM16	4.1
Haematopoietic and lymphoid	MOLM6	3.5
Haematopoietic and lymphoid	MOLP2	5.5
Haematopoietic and lymphoid	MOLP8	4.9
Haematopoietic and lymphoid	MOLT13	3.9
Haematopoietic and lymphoid	MOLT16	3.5
Haematopoietic and lymphoid	MOLT4	4
Haematopoietic and lymphoid	MONOMAC1	3.8
Haematopoietic and lymphoid	MONOMAC6	3.9
Haematopoietic and lymphoid	MOTN1	3.8
Haematopoietic and lymphoid	MUTZ5	3.7
Haematopoietic and lymphoid	MV411	3.6
Haematopoietic and lymphoid	NALM19	3.6
Haematopoietic and lymphoid	NALM1	4
Haematopoietic and lymphoid	NALM6	4
Haematopoietic and lymphoid	NAMALWA	3.6
Haematopoietic and lymphoid	NB4	3.8
Haematopoietic and lymphoid	NCIH929	4.7
Haematopoietic and lymphoid	NCO2	4.3
Haematopoietic and lymphoid	NOMO1	3.8
Haematopoietic and lymphoid	NUDHL1	4
Haematopoietic and lymphoid	NUDUL1	4.2
Haematopoietic and lymphoid	OCIAML2	4.1
Haematopoietic and lymphoid	OCIAML3	3.7
Haematopoietic and lymphoid	OCIAML5	4.2
Haematopoietic and lymphoid	OCILY10	4.6
Haematopoietic and lymphoid	OCILY19	4.3
Haematopoietic and lymphoid	OCILY3	3.8
Haematopoietic and lymphoid	OCIM1	3.8
Haematopoietic and lymphoid	OPM2	3.6
Haematopoietic and lymphoid	P12ICHIKAWA	4.3
Haematopoietic and lymphoid	P31FUJ	3.9
Haematopoietic and lymphoid	P3HR1	4.2
Haematopoietic and lymphoid	PCM6	5.3
Haematopoietic and lymphoid	PEER	4.4
Haematopoietic and lymphoid	PF382	4.3
Haematopoietic and lymphoid	PFEIFFER	4.1
Haematopoietic and lymphoid	PL21	3.9
Haematopoietic and lymphoid	RAJI	4.3
Haematopoietic and lymphoid	RCHACV	4.1
Haematopoietic and lymphoid	REC1	3.7
Haematopoietic and lymphoid	REH	4.4
Haematopoietic and lymphoid	RI1	3.8
Haematopoietic and lymphoid	RL	3.6
Haematopoietic and lymphoid	RPMI8226	3.7
Haematopoietic and lymphoid	RPMI8402	4.3
Haematopoietic and lymphoid	RS411	4
Haematopoietic and lymphoid	SEM	3.9
Haematopoietic and lymphoid	SET2	4.3
Haematopoietic and lymphoid	SIGM5	3.5
Haematopoietic and lymphoid	SKM1	3.5
Haematopoietic and lymphoid	SKMM2	3.7
Haematopoietic and lymphoid	SR786	3.7
Haematopoietic and lymphoid	ST486	3.8
Haematopoietic and lymphoid	SUDHL10	4
Haematopoietic and lymphoid	SUDHL1	3.8
Haematopoietic and lymphoid	SUDHL4	3.9
Haematopoietic and lymphoid	SUDHL5	4.1
Haematopoietic and lymphoid	SUDHL6	3.9
Haematopoietic and lymphoid	SUDHL8	3.8
Haematopoietic and lymphoid	SUPB15	4.3
Haematopoietic and lymphoid	SUPHD1	4
Haematopoietic and lymphoid	SUPM2	3.6
Haematopoietic and lymphoid	SUPT11	4
Haematopoietic and lymphoid	SUPT1	4.5
Haematopoietic and lymphoid	TALL1	5.7
Haematopoietic and lymphoid	TF1	3.8
Haematopoietic and lymphoid	THP1	3.8
Haematopoietic and lymphoid	TO175T	3.7
Haematopoietic and lymphoid	TOLEDO	4.3
Haematopoietic and lymphoid	U266B1	3.6
Haematopoietic and lymphoid	U937	3.9
Haematopoietic and lymphoid	UT7	3.8
Haematopoietic and lymphoid	WSUDLCL2	3.8
Kidney	769P	4
Kidney	786O	3.9
Kidney	A498	3.6
Kidney	A704	4.1
Kidney	ACHN	3.7
Kidney	BFTC909	3.7
Kidney	CAKI1	4.6
Kidney	CAKI2	3.9
Kidney	CAL54	3.6
Kidney	KMRC1	3.6
Kidney	KMRC20	3.8
Kidney	KMRC2	3.7
Kidney	KMRC3	3.9
Kidney	OSRC2	3.6
Kidney	RCC10RGB	3.7
Kidney	SNU1272	3.6
Kidney	SNU349	3.5
Kidney	TUHR10TKB	4
Kidney	TUHR14TKB	3.9
Kidney	TUHR4TKB	3.9
Kidney	VMRCRCW	3.4
Kidney	VMRCRCZ	3.8
Large intestine	C2BBE1	8.9
Large intestine	CCK81	5.5
Large intestine	CL11	5.1
Large intestine	CL14	5.5
Large intestine	CL34	4.7
Large intestine	CL40	4
Large intestine	COLO205	4.4
Large intestine	COLO320	3.8
Large intestine	COLO678	3.6
Large intestine	CW2	4.6
Large intestine	DLD1	4
Large intestine	GP2D	6.1
Large intestine	HCC56	3.9
Large intestine	HCT116	4.2
Large intestine	HCT15	3.6
Large intestine	HS675T	3.7
Large intestine	HS698T	3.7
Large intestine	HT115	7
Large intestine	HT29	4.1
Large intestine	HT55	5.6
Large intestine	KM12	8.9
Large intestine	LOVO	4.8
Large intestine	LS1034	4.3
Large intestine	LS123	5.7
Large intestine	LS180	5
Large intestine	LS411N	6.8
Large intestine	LS513	4.7
Large intestine	MDST8	4.5
Large intestine	NCIH508	4.6
Large intestine	NCIH716	7.9
Large intestine	NCIH747	6.3
Large intestine	OUMS23	5.2
Large intestine	RCM1	4.8
Large intestine	RKO	3.7
Large intestine	SKCO1	3.9
Large intestine	SNU1040	3.8
Large intestine	SNU1197	6.7
Large intestine	SNU175	6.7
Large intestine	SNU283	4.2
Large intestine	SNU407	4
Large intestine	SNU503	5.1
Large intestine	SNU61	6.8
Large intestine	SNU81	4
Large intestine	SNUC1	4.4
Large intestine	SNUC2A	5.2
Large intestine	SNUC4	3.9
Large intestine	SNUC5	5.6
Large intestine	SW1116	5.3
Large intestine	SW1417	3.7
Large intestine	SW1463	4.4
Large intestine	SW403	4
Large intestine	SW480	4.6
Large intestine	SW48	4
Large intestine	SW620	4.1
Large intestine	SW837	6.6
Large intestine	SW948	6.8
Large intestine	T84	4.2
Liver	ALEXANDERCELLS	3.7
Liver	C3A	4
Liver	HEP3B217	3.9
Liver	HEPG2	3.9
Liver	HLE	4
Liver	HLF	3.8
Liver	HUH1	3.9
Liver	HUH6	4.2
Liver	HUH7	4.4
Liver	JHH1	7.9
Liver	JHH2	4
Liver	JHH4	3.8
Liver	JHH5	6.5
Liver	JHH6	4.3
Liver	JHH7	4.6
Liver	LI7	3.6
Liver	PLCPRF5	3.8
Liver	SKHEP1	3.6
Liver	SNU182	4.2
Liver	SNU387	4.2
Liver	SNU398	3.8
Liver	SNU423	4
Liver	SNU449	3.7
Liver	SNU475	3.8
Liver	SNU761	4.4
Liver	SNU878	4
Liver	SNU886	3.7
Lung	A549	4.5
Lung	ABC1	4.1
Lung	BEN	5
Lung	CAL12T	4.2
Lung	CALU1	4.4
Lung	CALU3	4.5
Lung	CALU6	4.1
Lung	CHAGOK1	3.7
Lung	COLO668	4.4
Lung	COLO699	3.7
Lung	CORL105	3.8
Lung	CORL23	3.8
Lung	CORL24	4.3
Lung	CORL279	3.9
Lung	CORL311	4.2
Lung	CORL47	4.7
Lung	CORL51	5
Lung	CORL88	6.1
Lung	CORL95	5.6
Lung	CPCN	3.9
Lung	DMS114	4.6
Lung	DMS153	4.4
Lung	DMS273	4.2
Lung	DMS454	6.1
Lung	DMS53	8.7
Lung	DMS79	4.1
Lung	DV90	9.4
Lung	EBC1	5.8
Lung	EPLC272H	4.2
Lung	HARA	4.3
Lung	HCC1171	3.8
Lung	HCC1195	8.3
Lung	HCC15	4.2
Lung	HCC2279	7.1
Lung	HCC2935	5.3
Lung	HCC33	4
Lung	HCC366	3.9
Lung	HCC4006	5.7
Lung	HCC44	4.7
Lung	HCC78	5.8
Lung	HCC827	8.4
Lung	HCC95	4
Lung	HLC1	3.7
Lung	HLFA	3.4
Lung	HS229T	3.7
Lung	HS618T	3.9
Lung	IALM	6.2
Lung	KNS62	6.3
Lung	LC1F	4.3
Lung	LC1SQSF	5
Lung	LCLC103H	3.9
Lung	LCLC97TM1	5.8
Lung	LK2	4.1
Lung	LOUNH91	4
Lung	LU65	7.7
Lung	LU99	4.1
Lung	LUDLU1	6.5
Lung	LXF289	6.9
Lung	MORCPR	5.2
Lung	NCIH1048	4.2
Lung	NCIH1092	4.6
Lung	NCIH1105	4.6
Lung	NCIH1155	3.9
Lung	NCIH1184	4.4
Lung	NCIH1299	3.7
Lung	NCIH1339	3.9
Lung	NCIH1341	4
Lung	NCIH1355	4.7
Lung	NCIH1373	4.1
Lung	NCIH1385	4.5
Lung	NCIH1395	5.2
Lung	NCIH1435	4.1
Lung	NCIH1436	4.4
Lung	NCIH1437	3.8
Lung	NCIH146	6.5
Lung	NCIH1563	3.9
Lung	NCIH1568	4.8
Lung	NCIH1573	4.3
Lung	NCIH1581	3.9
Lung	NCIH1618	3.7
Lung	NCIH1623	6.8
Lung	NCIH1648	5.5
Lung	NCIH1650	4.3
Lung	NCIH1651	7.3
Lung	NCIH1666	5.4
Lung	NCIH1693	8.1
Lung	NCIH1694	4.1
Lung	NCIH1703	3.8
Lung	NCIH1734	6.2
Lung	NCIH1755	3.9
Lung	NCIH1781	8.2
Lung	NCIH1792	3.9
Lung	NCIH1793	5.1
Lung	NCIH1836	4
Lung	NCIH1838	8.3
Lung	NCIH1869	4.5
Lung	NCIH1876	4.1
Lung	NCIH1915	4.9
Lung	NCIH1930	4.3
Lung	NCIH1944	5.2
Lung	NCIH1963	3.8
Lung	NCIH196	3.9
Lung	NCIH1975	5
Lung	NCIH2009	5.1
Lung	NCIH2023	5.5
Lung	NCIH2029	4.4
Lung	NCIH2030	8.2
Lung	NCIH2066	4.4
Lung	NCIH2081	4.4
Lung	NCIH2085	4.2
Lung	NCIH2087	8
Lung	NCIH209	4.4
Lung	NCIH2106	3.8
Lung	NCIH2110	8.3
Lung	NCIH211	4.2
Lung	NCIH2122	6.3
Lung	NCIH2126	6.9
Lung	NCIH2141	4.2
Lung	NCIH2170	6.6
Lung	NCIH2171	4.4
Lung	NCIH2172	4
Lung	NCIH2196	3.8
Lung	NCIH2227	3.9
Lung	NCIH2228	6.3
Lung	NCIH226	4.2
Lung	NCIH2286	4.1
Lung	NCIH2291	4.1
Lung	NCIH2342	4.4
Lung	NCIH2347	4.5
Lung	NCIH23	4.3
Lung	NCIH2405	5
Lung	NCIH2444	5.1
Lung	NCIH292	4
Lung	NCIH322	4.8
Lung	NCIH3255	7.9
Lung	NCIH358	4.7
Lung	NCIH441	6.9
Lung	NCIH446	3.9
Lung	NCIH460	4.2
Lung	NCIH510	4.8
Lung	NCIH520	4.4
Lung	NCIH522	5.5
Lung	NCIH524	3.8
Lung	NCIH526	4
Lung	NCIH596	5.4
Lung	NCIH647	4.2
Lung	NCIH650	4.4
Lung	NCIH661	10.1
Lung	NCIH69	4.8
Lung	NCIH727	5.1
Lung	NCIH810	4.8
Lung	NCIH82	4.1
Lung	NCIH838	5.5
Lung	NCIH841	4.3
Lung	NCIH854	3.8
Lung	NCIH889	4
Lung	PC14	3.9
Lung	RERFLCAD1	3.7
Lung	RERFLCAD2	5.7
Lung	RERFLCAI	6
Lung	RERFLCKJ	6.5
Lung	RERFLCMS	3.7
Lung	RERFLCSQ1	4.1
Lung	SBC5	3.9
Lung	SCLC21H	4.1
Lung	SHP77	4.1
Lung	SKLU1	5.6
Lung	SKMES1	7.7
Lung	SQ1	4.6
Lung	SW1271	4
Lung	SW1573	3.8
Lung	SW900	5.9
Lung	VMRCLCD	3.9
Lung	VMRCLCP	4.3
Oesophagus	COLO680N	6.9
Oesophagus	ECGI10	7
Oesophagus	KYSE140	6.2
Oesophagus	KYSE150	4.9
Oesophagus	KYSE180	4.1
Oesophagus	KYSE270	4.1
Oesophagus	KYSE30	3.8
Oesophagus	KYSE410	3.8
Oesophagus	KYSE450	5.9
Oesophagus	KYSE510	5
Oesophagus	KYSE520	5.9
Oesophagus	KYSE70	3.9
Oesophagus	OE19	3.8
Oesophagus	OE33	4.6
Oesophagus	TE10	3.8
Oesophagus	TE11	4.3
Oesophagus	TE14	4.7
Oesophagus	TE15	5.8
Oesophagus	TE1	5.9
Oesophagus	TE4	6.5
Oesophagus	TE5	5.5
Oesophagus	TE6	7.4
Oesophagus	TE8	3.5
Oesophagus	TE9	5.5
Oesophagus	TT	7.6
Ovary	59M	3.8
Ovary	A2780	3.7
Ovary	CAOV3	3.9
Ovary	CAOV4	4.6
Ovary	COLO704	3.9
Ovary	COV318	7.2
Ovary	COV362	4
Ovary	COV434	3.9
Ovary	COV504	4
Ovary	COV644	7.3
Ovary	EFO21	6.6
Ovary	EFO27	4
Ovary	ES2	3.8
Ovary	FUOV1	3.9
Ovary	HEYA8	4.1
Ovary	HS571T	3.8
Ovary	IGROV1	4.7
Ovary	JHOC5	4.8
Ovary	JHOM1	3.9
Ovary	JHOM2B	6.6
Ovary	JHOS2	4.3
Ovary	JHOS4	6.1
Ovary	KURAMOCHI	3.8
Ovary	MCAS	4.3
Ovary	NIHOVCAR3	5.7
Ovary	OAW28	3.9
Ovary	OAW42	4.4
Ovary	OC314	4.1
Ovary	OC316	4.4
Ovary	ONCODG1	6.1
Ovary	OV56	4.3
Ovary	OV7	3.8
Ovary	OV90	7.5
Ovary	OVCAR4	4.1
Ovary	OVCAR8	3.9
Ovary	OVISE	3.7
Ovary	OVK18	3.7
Ovary	OVKATE	4.5
Ovary	OVMANA	7.9
Ovary	OVSAHO	4.1
Ovary	OVTOKO	4.1
Ovary	RMGI	3.9
Ovary	RMUGS	4.8
Ovary	SKOV3	3.8
Ovary	SNU119	5
Ovary	SNU840	4
Ovary	SNU8	5.5
Ovary	TOV112D	3.8
Ovary	TOV21G	3.7
Ovary	TYKNU	3.8
Pancreas	ASPC1	6.7
Pancreas	BXPC3	4.2
Pancreas	CAPAN1	6.2
Pancreas	CAPAN2	5.8
Pancreas	CFPAC1	4.5
Pancreas	DANG	5.2
Pancreas	HPAC	4.7
Pancreas	HPAFII	4.6
Pancreas	HS766T	4.5
Pancreas	HUPT3	4.7
Pancreas	HUPT4	5.2
Pancreas	KCIMOH1	3.8
Pancreas	KLM1	4.6
Pancreas	KP2	3.8
Pancreas	KP3	5
Pancreas	KP4	4.3
Pancreas	L33	6.1
Pancreas	MIAPACA2	3.7
Pancreas	PANC0203	6.5
Pancreas	PANC0213	5.6
Pancreas	PANC0327	4.2
Pancreas	PANC0403	4.9
Pancreas	PANC0504	4.2
Pancreas	PANC0813	4.3
Pancreas	PANC1005	4.2
Pancreas	PANC1	4.9
Pancreas	PATU8902	3.8
Pancreas	PATU8988S	5.2
Pancreas	PATU8988T	4.1
Pancreas	PK1	3.8
Pancreas	PK45H	3.7
Pancreas	PK59	4.8
Pancreas	PL45	4.1
Pancreas	PSN1	3.8
Pancreas	QGP1	3.5
Pancreas	SNU213	5.2
Pancreas	SNU324	6.3
Pancreas	SNU410	5.5
Pancreas	SU8686	6.3
Pancreas	SUIT2	5.3
Pancreas	SW1990	4.3
Pancreas	T3M4	4.4
Pancreas	TCCPAN2	5.8
Pancreas	YAPC	6.9
Pleura	ACCMESO1	3.5
Pleura	DM3	3.8
Pleura	ISTMES1	3.7
Pleura	ISTMES2	3.6
Pleura	JL1	3.9
Pleura	MPP89	4
Pleura	MSTO211H	4.1
Pleura	NCIH2052	3.8
Pleura	NCIH2452	3.5
Pleura	NCIH28	3.9
Prostate	22RV1	4
Prostate	DU145	6.7
Prostate	LNCAPCLONEFGC	3.7
Prostate	MDAPCA2B	3.7
Prostate	NCIH660	3.9
Prostate	PC3	3.9
Prostate	VCAP	4.3
Salivary gland	A253	5.6
Salivary gland	YD15	3.8
Skin	A101D	4.1
Skin	A2058	3.7
Skin	A375	3.9
Skin	C32	3.8
Skin	CHL1	3.8
Skin	CJM	3.8
Skin	COLO679	3.9
Skin	COLO741	4.1
Skin	COLO783	4.1
Skin	COLO792	3.9
Skin	COLO800	4.1
Skin	COLO818	3.6
Skin	COLO829	4
Skin	COLO849	3.6
Skin	G361	3.5
Skin	GRM	3.7
Skin	HMCB	4.1
Skin	HS294T	4.3
Skin	HS600T	3.6
Skin	HS688AT	4
Skin	HS695T	3.9
Skin	HS839T	3.8
Skin	HS852T	3.6
Skin	HS895T	3.8
Skin	HS934T	3.6
Skin	HS936T	3.6
Skin	HS939T	3.3
Skin	HS940T	3.9
Skin	HS944T	4.1
Skin	HT144	3.6
Skin	IGR1	3.5
Skin	IGR37	3.6
Skin	IGR39	3.6
Skin	IPC298	4
Skin	K029AX	3.9
Skin	LOXIMVI	3.9
Skin	MALME3M	4
Skin	MDAMB435S	3.6
Skin	MELHO	3.7
Skin	MELJUSO	4
Skin	MEWO	4.1
Skin	RPMI7951	3.7
Skin	RVH421	3.7
Skin	SH4	3.6
Skin	SKMEL1	3.8
Skin	SKMEL24	4.1
Skin	SKMEL28	3.6
Skin	SKMEL2	3.6
Skin	SKMEL30	3.7
Skin	SKMEL31	3.9
Skin	SKMEL3	3.9
Skin	SKMEL5	3.9
Skin	UACC257	3.8
Skin	UACC62	3.7
Skin	WM115	3.8
Skin	WM1799	3.8
Skin	WM2664	3.4
Skin	WM793	3.7
Skin	WM88	3.9
Skin	WM983B	3.7
Small intestine	HUTU80	3.9
Soft tissue	A204	3.9
Soft tissue	G401	4.2
Soft tissue	G402	5
Soft tissue	GCT	3.6
Soft tissue	HS729	3.7
Soft tissue	HT1080	3.8
Soft tissue	KYM1	3.7
Soft tissue	MESSA	3.8
Soft tissue	RD	3.6
Soft tissue	RH30	3.5
Soft tissue	RH41	4
Soft tissue	RKN	4.1
Soft tissue	S117	4.1
Soft tissue	SJRH30	3.9
Soft tissue	SKLMS1	6.2
Soft tissue	SKUT1	4
Soft tissue	TE125T	3.5
Soft tissue	TE159T	4
Soft tissue	TE441T	3.7
Soft tissue	TE617T	4
Stomach	2313287	3.5
Stomach	AGS	3.8
Stomach	AZ521	4.3
Stomach	ECC10	3.6
Stomach	ECC12	6.3
Stomach	FU97	4.1
Stomach	GCIY	6.4
Stomach	GSS	3.7
Stomach	GSU	6.1
Stomach	HGC27	3.8
Stomach	HS746T	4.8
Stomach	HUG1N	4.8
Stomach	IM95	5.5
Stomach	KATOIII	4.2
Stomach	KE39	4.2
Stomach	LMSU	3.8
Stomach	MKN1	6.4
Stomach	MKN45	3.7
Stomach	MKN74	3.7
Stomach	MKN7	4.7
Stomach	NCCSTCK140	5.1
Stomach	NCIN87	5.1
Stomach	NUGC2	5.1
Stomach	NUGC3	3.5
Stomach	NUGC4	7.3
Stomach	OCUM1	6
Stomach	RERFGC1B	5
Stomach	SH10TC	3.9
Stomach	SNU16	8.4
Stomach	SNU1	4.3
Stomach	SNU216	3.9
Stomach	SNU520	7.5
Stomach	SNU5	3.7
Stomach	SNU601	7.7
Stomach	SNU620	3.9
Stomach	SNU668	3.7
Stomach	SNU719	3.9
Stomach	TGBC11TKB	4.3
Thyroid	8305C	3.6
Thyroid	8505C	3.8
Thyroid	BCPAP	4.2
Thyroid	BHT101	3.9
Thyroid	CAL62	4
Thyroid	CGTHW1	3.5
Thyroid	FTC133	5.7
Thyroid	FTC238	4.1
Thyroid	ML1	3.9
Thyroid	SW579	3.7
Thyroid	TT2609C02	3.7
Thyroid	TT	4.8
Upper aerodigestive tract	BHY	4.7
Upper aerodigestive tract	BICR16	4
Upper aerodigestive tract	BICR18	6
Upper aerodigestive tract	BICR22	3.9
Upper aerodigestive tract	BICR31	7
Upper aerodigestive tract	BICR56	4.3
Upper aerodigestive tract	BICR6	3.7
Upper aerodigestive tract	CAL27	5.4
Upper aerodigestive tract	CAL33	4.3
Upper aerodigestive tract	DETROIT562	4.2
Upper aerodigestive tract	FADU	5.4
Upper aerodigestive tract	HS840T	3.7
Upper aerodigestive tract	HSC2	4.9
Upper aerodigestive tract	HSC3	3.8
Upper aerodigestive tract	HSC4	6.9
Upper aerodigestive tract	PECAPJ15	4
Upper aerodigestive tract	PECAPJ34CLONEC12	4.6
Upper aerodigestive tract	PECAPJ41CLONED2	4.5
Upper aerodigestive tract	PECAPJ49	4.3
Upper aerodigestive tract	SCC15	4.5
Upper aerodigestive tract	SCC25	4.5
Upper aerodigestive tract	SCC4	4.3
Upper aerodigestive tract	SCC9	3.9
Upper aerodigestive tract	SNU1076	3.8
Upper aerodigestive tract	SNU1214	4.4
Upper aerodigestive tract	SNU46	5.4
Upper aerodigestive tract	SNU899	5.6
Upper aerodigestive tract	YD10B	3.6
Upper aerodigestive tract	YD38	3.7
Upper aerodigestive tract	YD8	5.7
Urinary tract	5637	4.8
Urinary tract	639V	3.8
Urinary tract	647V	3.5
Urinary tract	BC3C	3.8
Urinary tract	BFTC905	4.6
Urinary tract	CAL29	3.6
Urinary tract	HS172T	4
Urinary tract	HT1197	3.8
Urinary tract	HT1376	3.9
Urinary tract	J82	3.9
Urinary tract	JMSU1	3.7
Urinary tract	KMBC2	5.4
Urinary tract	KU1919	6.9
Urinary tract	RT11284	4
Urinary tract	RT112	4
Urinary tract	RT4	3.7
Urinary tract	SCABER	4.4
Urinary tract	SW1710	3.5
Urinary tract	SW780	4.1
Urinary tract	T24	4.1
Urinary tract	TCCSUP	3.6
Urinary tract	UMUC1	3.9
Urinary tract	UMUC3	3.8
Urinary tract	VMCUB1	5

> The Human Protein Atlas (HPA)

Tissue	Expression Level (TPM)
Adipose tissue	0
Adrenal gland	0
Appendix	0
Bone marrow	0
Breast	0
Cerebral cortex	0
Cervix, uterine	0
Colon	0
Duodenum	0.3
Endometrium	0
Epididymis	0
Esophagus	0.1
Fallopian tube	0
Gallbladder	0.1
Heart muscle	0
Kidney	0
Liver	0
Lung	0.3
Lymph node	0
Ovary	0
Pancreas	0
Parathyroid gland	0
Placenta	0
Prostate	0
Rectum	0
Salivary gland	0
Seminal vesicle	0
Skeletal muscle	0
Skin	0
Small intestine	0
Smooth muscle	0
Spleen	0
Stomach	0.1
Testis	111.9
Thyroid gland	0
Tonsil	0
Urinary bladder	0

> Text Mining based Expression

PMID	Expression	Cancer	Evidence
28422722	overexpression	Pancreatic Carcinoma	STK31 was confirmed as a CT gene in PC and its expression was significantly higher in patients with new neoplasm compared with patients without new neoplasm (P = 0.046) and in more advanced pathologic stages than in earlier stages (P = 0.002); methylation level correlated negatively with STK31 expression.
28412729	overexpression	Colorectal Carcinoma	STK31 expression levels in primary tumorous tissues of metastatic patients were significantly higher than in ANCTs and in lymph nodes samples, both at the RNA level and the protein level.
18281482	Overexpression	Colorectal Carcinoma	Reverse transcription-PCR analysis showed that STK31 gene expression levels in cancer samples were significantly higher (P < 0.0001) than those in normal samples.
24667656	Overexpression	Colorectal Carcinoma	Here, we demonstrate that STK31 is overexpressed in many human colorectal cancer cell lines and tissues.

Summary
Symbol	STK31
Name	serine/threonine kinase 31
Aliases	TDRD8; SgK396; serine/threonine-protein kinase NYD-SPK; sugen kinase 396; tudor domain containing 8; Serine/ ......
Location	7p15.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.192	0.000107	5.4	49.8	44.8	Gain
BRCA	Breast invasive carcinoma	1075	0.142	3.12e-06	11.1	56.7	32.3	Neutral
CESC	Cervical and endocervical cancers	292	0.117	0.0453	8.9	76	15.1	Neutral
COAD	Colon adenocarcinoma	449	0.377	1.32e-16	0.4	43	56.6	Gain
ESCA	Esophageal carcinoma	183	0.445	2.65e-10	4.4	27.9	67.8	Gain
HNSC	Head and Neck squamous cell carcinoma	514	0.29	1.98e-11	5.1	57.2	37.7	Gain
LUAD	Lung adenocarcinoma	512	0.39	5.27e-20	5.7	40.4	53.9	Gain
LUSC	Lung squamous cell carcinoma	498	0.185	3.4e-05	12.2	37.1	50.6	Gain
OV	Ovarian serous cystadenocarcinoma	300	0.28	8.13e-07	34.7	39	26.3	Loss
PAAD	Pancreatic adenocarcinoma	177	0.095	0.207	1.7	70.1	28.2	Neutral
READ	Rectum adenocarcinoma	164	0.327	1.93e-05	0.6	35.4	64	Gain
SARC	Sarcoma	255	0.235	0.000147	11.8	52.5	35.7	Gain
SKCM	Skin Cutaneous Melanoma	367	0.147	0.00472	6	38.4	55.6	Gain
STAD	Stomach adenocarcinoma	413	0.359	5.07e-14	3.6	46.7	49.6	Gain
TGCT	Testicular Germ Cell Tumors	150	0.19	0.0198	1.3	15.3	83.3	Gain
THYM	Thymoma	119	-0.112	0.223	1.7	86.6	11.8	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.234	4.33e-08	9.3	76.2	14.5	Neutral

Summary
Symbol	STK31
Name	serine/threonine kinase 31
Aliases	TDRD8; SgK396; serine/threonine-protein kinase NYD-SPK; sugen kinase 396; tudor domain containing 8; Serine/ ......
Location	7p15.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.098	0.044	17	408	-0.019	0.00121	NS/NA
BRCA	Breast invasive carcinoma	-0.052	0.124	83	785	-0.005	2.97e-07	NS/NA
CESC	Cervical and endocervical cancers	-0.153	0.007	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.458	0	19	297	-0.036	1.97e-09	NS/NA
ESCA	Esophageal carcinoma	-0.543	0	9	185	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.114	0.00786	20	522	0.004	0.532	NS/NA
LUAD	Lung adenocarcinoma	-0.137	0.00265	21	456	-0.021	0.000134	NS/NA
LUSC	Lung squamous cell carcinoma	-0.025	0.627	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.183	0.644	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.651	0	4	179	NA	NA	NS/NA
READ	Rectum adenocarcinoma	-0.536	1.3e-08	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.089	0.152	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.13	0.0046	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.671	0	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.75	0	0	156	NA	NA	NS/NA
THYM	Thymoma	-0.125	0.17	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.103	0.0267	34	431	-0.002	0.000277	NS/NA

Summary
Symbol	STK31
Name	serine/threonine kinase 31
Aliases	TDRD8; SgK396; serine/threonine-protein kinase NYD-SPK; sugen kinase 396; tudor domain containing 8; Serine/ ......
Location	7p15.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

Tissue	Level	Level Name
Adrenal gland	0	Not detected
Appendix	0	Not detected
Bone marrow	0	Not detected
Breast	0	Not detected
Bronchus	0	Not detected
Caudate	0	Not detected
Cerebellum	0	Not detected
Cerebral cortex	0	Not detected
Cervix, uterine	0	Not detected
Colon	0	Not detected
Duodenum	0	Not detected
Endometrium	0	Not detected
Epididymis	0	Not detected
Esophagus	0	Not detected
Fallopian tube	0	Not detected
Gallbladder	0	Not detected
Heart muscle	0	Not detected
Hippocampus	0	Not detected
Kidney	0	Not detected
Liver	0	Not detected
Lung	0	Not detected
Lymph node	0	Not detected
Nasopharynx	0	Not detected
Oral mucosa	0	Not detected
Ovary	0	Not detected
Pancreas	0	Not detected
Parathyroid gland	0	Not detected
Placenta	0	Not detected
Prostate	0	Not detected
Rectum	0	Not detected
Salivary gland	0	Not detected
Seminal vesicle	0	Not detected
Skeletal muscle	0	Not detected
Skin	0	Not detected
Small intestine	0	Not detected
Smooth muscle	0	Not detected
Soft tissue	0	Not detected
Spleen	0	Not detected
Stomach	0	Not detected
Testis	3	High
Thyroid gland	0	Not detected
Tonsil	0	Not detected
Urinary bladder	0	Not detected
Vagina	0	Not detected

Summary
Symbol	STK31
Name	serine/threonine kinase 31
Aliases	TDRD8; SgK396; serine/threonine-protein kinase NYD-SPK; sugen kinase 396; tudor domain containing 8; Serine/ ......
Location	7p15.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.192	NS	24476821
BRCA	Breast invasive carcinoma	521	0.0197	Significant	23000897
COAD	Colon adenocarcinoma	149	0.0137	Significant	22810696
HNSC	Head and Neck squamous cell carcinoma	279	7.97e-05	Significant	25631445
LUAD	Lung adenocarcinoma	230	0.055	NS	25079552
LUSC	Lung squamous cell carcinoma	178	2.19e-05	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.014	Significant	21720365
READ	Rectum adenocarcinoma	67	0.201	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.000269	Significant	26091043
STAD	Stomach adenocarcinoma	277	3.2e-08	Significant	25079317
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.000444	Significant	23636398

> Overall survival

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	0.935	0.748	NS
BRCA	Breast invasive carcinoma	1079	1.377	0.134	NS
CESC	Cervical and endocervical cancers	291	1.408	0.32	NS
COAD	Colon adenocarcinoma	439	1.671	0.0556	NS
ESCA	Esophageal carcinoma	184	1.214	0.518	NS
HNSC	Head and Neck squamous cell carcinoma	518	1.16	0.424	NS
LUAD	Lung adenocarcinoma	502	1.51	0.0498	Shorter
LUSC	Lung squamous cell carcinoma	494	0.825	0.306	NS
OV	Ovarian serous cystadenocarcinoma	303	1.078	0.715	NS
PAAD	Pancreatic adenocarcinoma	177	2.017	0.0224	Shorter
READ	Rectum adenocarcinoma	159	0.735	0.565	NS
SARC	Sarcoma	259	0.946	0.847	NS
SKCM	Skin Cutaneous Melanoma	459	0.68	0.0474	Longer
STAD	Stomach adenocarcinoma	388	1.053	0.813	NS
TGCT	Testicular Germ Cell Tumors	134	0	0.0903	NS
THYM	Thymoma	119	0.53	0.46	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	1.244	0.435	NS

> Stage

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	0.044	0.373	NS
BRCA	Breast invasive carcinoma	1071	-0.026	0.387	NS
CESC	Cervical and endocervical cancers	167	-0.147	0.0579	NS
COAD	Colon adenocarcinoma	445	0.139	0.00333	Higher
ESCA	Esophageal carcinoma	162	0.103	0.191	NS
HNSC	Head and Neck squamous cell carcinoma	448	0.076	0.109	NS
LUAD	Lung adenocarcinoma	507	0.04	0.369	NS
LUSC	Lung squamous cell carcinoma	497	0.008	0.859	NS
OV	Ovarian serous cystadenocarcinoma	302	0	0.993	NS
PAAD	Pancreatic adenocarcinoma	176	0.166	0.0273	Higher
READ	Rectum adenocarcinoma	156	0.049	0.545	NS
SKCM	Skin Cutaneous Melanoma	410	0.034	0.493	NS
STAD	Stomach adenocarcinoma	392	0.091	0.0708	NS
TGCT	Testicular Germ Cell Tumors	81	-0.411	0.000138	Lower
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.102	0.0228	Higher

> Grade

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	-0.097	0.112	NS
HNSC	Head and Neck squamous cell carcinoma	498	-0.098	0.0281	Lower
OV	Ovarian serous cystadenocarcinoma	296	0.037	0.526	NS
PAAD	Pancreatic adenocarcinoma	176	0.266	0.000354	Higher
STAD	Stomach adenocarcinoma	406	-0.233	2.03e-06	Lower
UCEC	Uterine Corpus Endometrial Carcinoma	534	-0.053	0.219	NS

Summary
Symbol	STK31
Name	serine/threonine kinase 31
Aliases	TDRD8; SgK396; serine/threonine-protein kinase NYD-SPK; sugen kinase 396; tudor domain containing 8; Serine/ ......
Location	7p15.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	STK31
Name	serine/threonine kinase 31
Aliases	TDRD8; SgK396; serine/threonine-protein kinase NYD-SPK; sugen kinase 396; tudor domain containing 8; Serine/ ......
Location	7p15.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for STK31.

Summary
Symbol	STK31
Name	serine/threonine kinase 31
Aliases	TDRD8; SgK396; serine/threonine-protein kinase NYD-SPK; sugen kinase 396; tudor domain containing 8; Serine/ ......
Location	7p15.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]
There is no record for STK31.

> Interactions from Text Mining

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
24667656	Colorectal Carcinoma	partner	Pericentrin	Colocalization	STK31 co-localizes with pericentrin in the centrosomal region throughout all phases of the cell cycle.