CR2Cancer

Summary
Symbol	SUV39H1
Name	suppressor of variegation 3-9 homolog 1
Aliases	KMT1A; SUV39H; suppressor of variegation 3-9 (Drosophila) homolog 1; H3-K9-HMTase 1; MG44; Su(var)3-9 homolo ......
Location	Xp11.23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

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Domain

PF00385 Chromo (CHRromatin Organisation MOdifier) domain
PF05033 Pre-SET motif
PF00856 SET domain

Function

Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. Also weakly methylates histone H1 (in vitro). H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as repression of MYOD1-stimulated differentiation, regulation of the control switch for exiting the cell cycle and entering differentiation, repression by the PML-RARA fusion protein, BMP-induced repression, repression of switch recombination to IgA and regulation of telomere length. Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation.

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification write, Histone modification write	Histone methylation, Histone phosphorylation	H3S10, H3K9me1, H4	H3K9me3	10949293

> Gene Ontology [ TOP ]
Biological Process	GO:0000183 chromatin silencing at rDNA GO:0001666 response to hypoxia GO:0006342 chromatin silencing GO:0006364 rRNA processing GO:0006479 protein methylation GO:0007623 circadian rhythm GO:0008213 protein alkylation GO:0016072 rRNA metabolic process GO:0016458 gene silencing GO:0016570 histone modification GO:0016571 histone methylation GO:0018022 peptidyl-lysine methylation GO:0018023 peptidyl-lysine trimethylation GO:0018027 peptidyl-lysine dimethylation GO:0018205 peptidyl-lysine modification GO:0022613 ribonucleoprotein complex biogenesis GO:0032259 methylation GO:0034470 ncRNA processing GO:0034968 histone lysine methylation GO:0036123 histone H3-K9 dimethylation GO:0036124 histone H3-K9 trimethylation GO:0036293 response to decreased oxygen levels GO:0036294 cellular response to decreased oxygen levels GO:0040029 regulation of gene expression, epigenetic GO:0042254 ribosome biogenesis GO:0042752 regulation of circadian rhythm GO:0042754 negative regulation of circadian rhythm GO:0043414 macromolecule methylation GO:0045814 negative regulation of gene expression, epigenetic GO:0048511 rhythmic process GO:0051567 histone H3-K9 methylation GO:0061647 histone H3-K9 modification GO:0070482 response to oxygen levels GO:0071453 cellular response to oxygen levels GO:0071456 cellular response to hypoxia
Molecular Function	GO:0003682 chromatin binding GO:0008168 methyltransferase activity GO:0008170 N-methyltransferase activity GO:0008276 protein methyltransferase activity GO:0008757 S-adenosylmethionine-dependent methyltransferase activity GO:0016278 lysine N-methyltransferase activity GO:0016279 protein-lysine N-methyltransferase activity GO:0016741 transferase activity, transferring one-carbon groups GO:0018024 histone-lysine N-methyltransferase activity GO:0042054 histone methyltransferase activity GO:0046974 histone methyltransferase activity (H3-K9 specific) GO:0047485 protein N-terminus binding
Cellular Component	GO:0000775 chromosome, centromeric region GO:0000785 chromatin GO:0000792 heterochromatin GO:0000793 condensed chromosome GO:0000794 condensed nuclear chromosome GO:0005652 nuclear lamina GO:0005677 chromatin silencing complex GO:0017053 transcriptional repressor complex GO:0033553 rDNA heterochromatin GO:0034399 nuclear periphery GO:0090568 nuclear transcriptional repressor complex GO:0098687 chromosomal region

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa00310 Lysine degradation
Reactome	R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-212165: Epigenetic regulation of gene expression R-HSA-74160: Gene Expression R-HSA-5250941: Negative epigenetic regulation of rRNA expression R-HSA-3214841: PKMTs methylate histone lysines R-HSA-427359: SIRT1 negatively regulates rRNA Expression

Summary
Symbol	SUV39H1
Name	suppressor of variegation 3-9 homolog 1
Aliases	KMT1A; SUV39H; suppressor of variegation 3-9 (Drosophila) homolog 1; H3-K9-HMTase 1; MG44; Su(var)3-9 homolo ......
Location	Xp11.23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

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COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM4972276	c.284G>A	p.R95K	Substitution - Missense	Thyroid
COSM6005349	c.1162C>T	p.L388F	Substitution - Missense	Prostate
COSM3668741	c.301C>T	p.H101Y	Substitution - Missense	Liver
COSM1122153	c.706G>A	p.V236M	Substitution - Missense	Endometrium
COSM1195681	c.85T>C	p.S29P	Substitution - Missense	Lung
COSM3406419	c.1074C>T	p.G358G	Substitution - coding silent	Central_nervous_system
COSM356258	c.742T>G	p.F248V	Substitution - Missense	Lung
COSM4883645	c.704G>T	p.R235L	Substitution - Missense	Upper_aerodigestive_tract
COSM1122145	c.159G>T	p.K53N	Substitution - Missense	Endometrium
COSM1625939	c.1065C>T	p.I355I	Substitution - coding silent	Liver
COSM1267057	c.703C>T	p.R235C	Substitution - Missense	Oesophagus
COSM5726682	c.1035C>T	p.P345P	Substitution - coding silent	Skin
COSM5412744	c.480C>T	p.F160F	Substitution - coding silent	Skin
COSM1122151	c.448G>A	p.E150K	Substitution - Missense	Endometrium
COSM6005349	c.1162C>T	p.L388F	Substitution - Missense	Prostate
COSM6005349	c.1162C>T	p.L388F	Substitution - Missense	Prostate
COSM1122143	c.69C>T	p.C23C	Substitution - coding silent	Endometrium
COSM3973698	c.717G>C	p.K239N	Substitution - Missense	Central_nervous_system
COSM757134	c.614A>G	p.Y205C	Substitution - Missense	Lung
COSM372494	c.1153C>G	p.L385V	Substitution - Missense	Lung
COSM5519869	c.1037G>A	p.R346H	Substitution - Missense	Biliary_tract
COSM4109784	c.772G>A	p.V258I	Substitution - Missense	Stomach
COSM5104363	c.1105+3delG	p.?	Unknown	Large_intestine
COSM488404	c.135C>A	p.V45V	Substitution - coding silent	Kidney
COSM5412745	c.775C>A	p.R259S	Substitution - Missense	Skin
COSM4884240	c.1133G>T	p.R378L	Substitution - Missense	Upper_aerodigestive_tract
COSM4931967	c.259A>T	p.K87*	Substitution - Nonsense	Liver
COSM757133	c.856C>T	p.R286W	Substitution - Missense	Lung
COSM2966525	c.139T>C	p.Y47H	Substitution - Missense	Large_intestine
COSM5896503	c.469C>T	p.P157S	Substitution - Missense	Skin
COSM5963888	c.590G>C	p.G197A	Substitution - Missense	Breast
COSM241808	c.875G>A	p.R292H	Substitution - Missense	Prostate
COSM1468237	c.634C>T	p.R212W	Substitution - Missense	Large_intestine
COSM1122161	c.1183C>T	p.R395W	Substitution - Missense	Endometrium
COSM4109785	c.773T>A	p.V258D	Substitution - Missense	Stomach
COSM5742266	c.872A>G	p.D291G	Substitution - Missense	Small_intestine
COSM4391571	c.133G>T	p.V45F	Substitution - Missense	Breast
COSM5366943	c.750G>A	p.T250T	Substitution - coding silent	Large_intestine
COSM4884035	c.464G>T	p.G155V	Substitution - Missense	Upper_aerodigestive_tract
COSM5366943	c.750G>A	p.T250T	Substitution - coding silent	Large_intestine
COSM1228036	c.657C>G	p.I219M	Substitution - Missense	Large_intestine
COSM5367200	c.297G>A	p.R99R	Substitution - coding silent	Large_intestine
COSM129509	c.1114G>A	p.V372M	Substitution - Missense	Upper_aerodigestive_tract
COSM1122147	c.171G>T	p.Q57H	Substitution - Missense	Endometrium
COSM4109786	c.871G>T	p.D291Y	Substitution - Missense	Stomach
COSM1122141	c.21C>A	p.G7G	Substitution - coding silent	Endometrium
COSM6005349	c.1162C>T	p.L388F	Substitution - Missense	Prostate
COSM5064714	c.603C>T	p.H201H	Substitution - coding silent	Stomach
COSM1228035	c.1138G>A	p.D380N	Substitution - Missense	Large_intestine
COSM1582830	c.1133G>A	p.R378H	Substitution - Missense	Stomach
COSM4521651	c.1122G>A	p.M374I	Substitution - Missense	Skin
COSM3561965	c.385C>T	p.R129C	Substitution - Missense	Skin
COSM1625939	c.1065C>T	p.I355I	Substitution - coding silent	Liver
COSM4889973	c.672C>G	p.S224S	Substitution - coding silent	Upper_aerodigestive_tract
COSM1122159	c.882C>T	p.G294G	Substitution - coding silent	Endometrium
COSM1228036	c.657C>G	p.I219M	Substitution - Missense	Large_intestine
COSM2966524	c.135C>T	p.V45V	Substitution - coding silent	Large_intestine
COSM1468238	c.1042G>A	p.A348T	Substitution - Missense	Large_intestine
COSM1756600	c.939C>A	p.A313A	Substitution - coding silent	Urinary_tract
COSM5017123	c.733C>A	p.L245I	Substitution - Missense	Kidney
COSM5698683	c.66G>T	p.L22L	Substitution - coding silent	Soft_tissue
COSM5718276	c.91C>T	p.P31S	Substitution - Missense	Skin
COSM1122157	c.864G>T	p.Q288H	Substitution - Missense	Endometrium
COSM3940010	c.875G>C	p.R292P	Substitution - Missense	Oesophagus
COSM1122155	c.771C>T	p.G257G	Substitution - coding silent	Endometrium
COSM1468235	c.57G>A	p.L19L	Substitution - coding silent	Large_intestine
COSM1756600	c.939C>A	p.A313A	Substitution - coding silent	Urinary_tract
COSM1756601	c.1164C>T	p.L388L	Substitution - coding silent	Urinary_tract
COSM5696753	c.532G>A	p.A178T	Substitution - Missense	Soft_tissue
COSM1122149	c.273G>A	p.K91K	Substitution - coding silent	Endometrium
COSM3668741	c.301C>T	p.H101Y	Substitution - Missense	Liver
COSM1468236	c.588delG	p.A198fs*140	Deletion - Frameshift	Large_intestine
COSM4109783	c.646G>A	p.G216R	Substitution - Missense	Stomach
COSM4754634	c.174A>C	p.E58D	Substitution - Missense	Stomach
COSM4820115	c.397C>A	p.Q133K	Substitution - Missense	Cervix
COSM1756601	c.1164C>T	p.L388L	Substitution - coding silent	Urinary_tract
COSM4109782	c.431G>A	p.R144H	Substitution - Missense	Stomach
COSM2966531	c.673C>T	p.R225C	Substitution - Missense	Stomach
COSM3844849	c.308G>A	p.R103Q	Substitution - Missense	Breast
COSM5422866	c.917A>G	p.D306G	Substitution - Missense	Pleura
COSM3844850	c.1224C>T	p.R408R	Substitution - coding silent	Breast
COSM1163566	c.593C>T	p.A198V	Substitution - Missense	Pancreas
COSM4389815	c.6G>A	p.A2A	Substitution - coding silent	Pancreas

> Text Mining based Variations [ TOP ]
There is no record for SUV39H1.

Summary
Symbol	SUV39H1
Name	suppressor of variegation 3-9 homolog 1
Aliases	KMT1A; SUV39H; suppressor of variegation 3-9 (Drosophila) homolog 1; H3-K9-HMTase 1; MG44; Su(var)3-9 homolo ......
Location	Xp11.23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

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Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
O43463	391	S	Phosphoserine	-	No	None detected

Summary
Symbol	SUV39H1
Name	suppressor of variegation 3-9 homolog 1
Aliases	KMT1A; SUV39H; suppressor of variegation 3-9 (Drosophila) homolog 1; H3-K9-HMTase 1; MG44; Su(var)3-9 homolo ......
Location	Xp11.23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

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Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	3.236	4.192	0.923	1.77e-06	Over
BRCA	Breast invasive carcinoma	112	1100	3.262	3.894	0.678	7.09e-29	Over
CESC	Cervical and endocervical cancers	3	306	3.52	4.862	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	3.465	4.499	1.102	1.27e-23	Over
ESCA	Esophageal carcinoma	11	185	2.92	4.169	1.002	0.000264	Over
GBM	Glioblastoma multiforme	5	166	3.891	4.291	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	3.431	4.03	0.622	6.93e-07	Over
KIRC	Kidney renal clear cell carcinoma	72	534	2.777	3.257	0.545	2.64e-19	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	3.03	3.103	0.187	0.0728	NS
LAML	Acute Myeloid Leukemia	0	173	NA	4.634	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	3.847	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	3.069	3.929	0.812	3.9e-13	Over
LUAD	Lung adenocarcinoma	59	517	3.065	3.547	0.55	4.52e-09	NS
LUSC	Lung squamous cell carcinoma	51	501	2.907	4.3	1.308	1.86e-38	Over
OV	Ovarian serous cystadenocarcinoma	0	307	NA	4.391	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	2.722	3.124	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	2.082	3.747	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	3.046	3.113	0.064	0.311	NS
READ	Rectum adenocarcinoma	10	167	3.352	4.699	1.285	2.08e-07	Over
SARC	Sarcoma	2	263	3.033	4.213	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	3.991	4.281	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	3.515	4.128	0.679	6.49e-07	Over
TGCT	Testicular Germ Cell Tumors	0	156	NA	4.534	NA	NA	NA
THCA	Thyroid carcinoma	59	509	2.898	2.747	-0.129	0.0133	NS
THYM	Thymoma	2	120	4.421	4.736	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	3.377	4.161	0.858	2.93e-11	Over

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

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Tissue	Expression Level (TPM)
Adipose tissue	3.3
Adrenal gland	1.8
Appendix	5.5
Bone marrow	8
Breast	3.3
Cerebral cortex	6.5
Cervix, uterine	2.9
Colon	3
Duodenum	3
Endometrium	3.9
Epididymis	14.3
Esophagus	3.5
Fallopian tube	4.7
Gallbladder	2.5
Heart muscle	2.4
Kidney	2
Liver	2.2
Lung	4
Lymph node	8.3
Ovary	4.4
Pancreas	0.3
Parathyroid gland	3
Placenta	4.5
Prostate	3.2
Rectum	3.4
Salivary gland	0.9
Seminal vesicle	4
Skeletal muscle	1.4
Skin	4.9
Small intestine	3
Smooth muscle	3.6
Spleen	4.9
Stomach	2.1
Testis	5.5
Thyroid gland	3.4
Tonsil	6.3
Urinary bladder	3

> Text Mining based Expression

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PMID	Expression	Cancer	Evidence
25602259	aberrant expression	Brain Glioblastoma	SETDB1 and cytoplasmic SUV39H1 levels increased from normal brain through low-grade to high-grade tumors, nuclear SUV39H1 correlating inversely with grade.
24844570	overexpression	Hepatocellular Carcinoma	Real-time polymerase chain reaction analysis indicated high levels of SUV39H1 expression in 24 of 42 (57.1%) HCC surgical samples compared with corresponding nontumor tissues.
24737085	overexpression	Gastric Carcinoma	We found that the expression of Suv39H1 and tri-methylated H3K9 in gastric carcinoma was higher than that in benign gastric diseases (p<0.05).
24564251	overexpression	Non-Small Cell Lung Carcinoma	Our results suggest that overexpression of HMGA1, E2F6, IRF1, and TFDP1 and downregulation or no expression of SUV39H1, RBL1, and HNRPD in blood is suitable for diagnosis of lung adenocarcinoma and squamous cell carcinoma sub-types of NSCLC.
23943221	overexpression	Glioma	Our results indicate overexpression of SETDB1 and SUV39H1 in gliomas.
22991213	overexpression	Hepatocellular Carcinoma	In this study, we found that SUV39H1 was frequently up-regulated in human HCCs and was significantly associated with increased Ki67 expression (P < 0.001) and the presence of venous invasion (P = 0.017).
17657744	overexpression	Colorectal Carcinoma	The mRNA levels of SUV39H1 and DNMT1 were elevated in 25% and 42% of 219 colorectal cancers, respectively.

Summary
Symbol	SUV39H1
Name	suppressor of variegation 3-9 homolog 1
Aliases	KMT1A; SUV39H; suppressor of variegation 3-9 (Drosophila) homolog 1; H3-K9-HMTase 1; MG44; Su(var)3-9 homolo ......
Location	Xp11.23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

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Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.198	6.41e-05	20.3	62.4	17.3	Neutral
BRCA	Breast invasive carcinoma	1075	0.202	2.5e-11	16.7	66.8	16.5	Neutral
CESC	Cervical and endocervical cancers	292	0.271	2.56e-06	23.6	63	13.4	Neutral
COAD	Colon adenocarcinoma	449	0.053	0.263	15.8	68.8	15.4	Neutral
ESCA	Esophageal carcinoma	183	0.237	0.00123	36.6	50.8	12.6	Loss
GBM	Glioblastoma multiforme	147	0.008	0.927	24.5	72.8	2.7	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.19	1.5e-05	28.2	63.4	8.4	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.283	3.75e-11	9	85.3	5.7	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	-0.277	1.73e-06	11.5	55.9	32.6	Neutral
LAML	Acute Myeloid Leukemia	166	-0.093	0.231	3	95.8	1.2	Neutral
LGG	Brain Lower Grade Glioma	513	0.105	0.0178	18.9	76.2	4.9	Neutral
LIHC	Liver hepatocellular carcinoma	364	-0.086	0.103	27.2	62.4	10.4	Neutral
LUAD	Lung adenocarcinoma	512	0.383	2.74e-19	20.1	67.8	12.1	Neutral
LUSC	Lung squamous cell carcinoma	498	0.247	2.25e-08	26.7	59.2	14.1	Neutral
OV	Ovarian serous cystadenocarcinoma	300	0.54	4.32e-24	43.3	28.7	28	Loss
PAAD	Pancreatic adenocarcinoma	177	0.247	0.000934	14.7	80.2	5.1	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	-0.091	0.247	27.2	67.9	4.9	Neutral
PRAD	Prostate adenocarcinoma	491	0.184	3.95e-05	5.5	90.8	3.7	Neutral
READ	Rectum adenocarcinoma	164	0.12	0.125	18.3	63.4	18.3	Neutral
SARC	Sarcoma	255	0.401	2.97e-11	20.4	45.1	34.5	Gain
SKCM	Skin Cutaneous Melanoma	367	0.132	0.0114	23.2	62.1	14.7	Neutral
STAD	Stomach adenocarcinoma	413	0.22	6.52e-06	14.8	72.2	13.1	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.189	0.0206	18.7	63.3	18	Neutral
THCA	Thyroid carcinoma	497	0.022	0.632	0.8	97.6	1.6	Neutral
THYM	Thymoma	119	0.109	0.237	6.7	91.6	1.7	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.25	4.38e-09	11.4	72.1	16.6	Neutral

Summary
Symbol	SUV39H1
Name	suppressor of variegation 3-9 homolog 1
Aliases	KMT1A; SUV39H; suppressor of variegation 3-9 (Drosophila) homolog 1; H3-K9-HMTase 1; MG44; Su(var)3-9 homolo ......
Location	Xp11.23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

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Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.101	0.038	17	408	-0.01	0.0418	NS/NA
BRCA	Breast invasive carcinoma	-0.127	0.000188	83	785	0.02	0.231	NS/NA
CESC	Cervical and endocervical cancers	-0.17	0.00273	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.105	0.0619	19	297	0.011	0.58	NS/NA
ESCA	Esophageal carcinoma	-0.235	0.00098	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	0.151	0.23	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.203	1.96e-06	20	522	0	0.879	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.053	0.33	24	319	-0.001	0.0851	NS/NA
KIRP	Kidney renal papillary cell carcinoma	0.059	0.311	23	275	-0.02	0.187	NS/NA
LAML	Acute Myeloid Leukemia	-0.189	0.0137	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.087	0.0451	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.157	0.00136	41	373	-0.003	0.0246	NS/NA
LUAD	Lung adenocarcinoma	-0.252	2.86e-08	21	456	-0.005	0.252	NS/NA
LUSC	Lung squamous cell carcinoma	-0.171	0.000857	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	0.067	0.88	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	0.02	0.79	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.084	0.255	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.153	0.000405	35	498	-0.009	0.00441	NS/NA
READ	Rectum adenocarcinoma	-0.134	0.181	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.024	0.702	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.082	0.0768	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.134	0.00954	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.221	0.00571	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.071	0.0936	50	509	-0.043	0.103	NS/NA
THYM	Thymoma	-0.066	0.47	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.111	0.0171	34	431	0.024	0.9	NS/NA

Summary
Symbol	SUV39H1
Name	suppressor of variegation 3-9 homolog 1
Aliases	KMT1A; SUV39H; suppressor of variegation 3-9 (Drosophila) homolog 1; H3-K9-HMTase 1; MG44; Su(var)3-9 homolo ......
Location	Xp11.23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA) [ TOP ]
There is no antibody staining data.

Summary
Symbol	SUV39H1
Name	suppressor of variegation 3-9 homolog 1
Aliases	KMT1A; SUV39H; suppressor of variegation 3-9 (Drosophila) homolog 1; H3-K9-HMTase 1; MG44; Su(var)3-9 homolo ......
Location	Xp11.23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.551	NS	24476821
BRCA	Breast invasive carcinoma	521	1.13e-31	Significant	23000897
COAD	Colon adenocarcinoma	149	0.0454	Significant	22810696
GBM	Glioblastoma multiforme	157	0.322	NS	26824661
HNSC	Head and Neck squamous cell carcinoma	279	0.000307	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.0728	NS	26536169
LGG	Brain Lower Grade Glioma	513	4.06e-13	Significant	26824661
LUAD	Lung adenocarcinoma	230	4.3e-09	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	1.39e-07	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	9.83e-05	Significant	21720365
PRAD	Prostate adenocarcinoma	333	0.0138	Significant	26544944
READ	Rectum adenocarcinoma	67	0.258	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.109	NS	26091043
STAD	Stomach adenocarcinoma	277	1.83e-06	Significant	25079317
THCA	Thyroid carcinoma	391	0.028	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	4.42e-15	Significant	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	0.906	0.636	NS
BRCA	Breast invasive carcinoma	1079	1.061	0.789	NS
CESC	Cervical and endocervical cancers	291	0.423	0.0127	Longer
COAD	Colon adenocarcinoma	439	0.946	0.843	NS
ESCA	Esophageal carcinoma	184	1.927	0.0462	Shorter
GBM	Glioblastoma multiforme	158	1.006	0.985	NS
HNSC	Head and Neck squamous cell carcinoma	518	0.821	0.339	NS
KIRC	Kidney renal clear cell carcinoma	531	1.734	0.0122	Shorter
KIRP	Kidney renal papillary cell carcinoma	287	1.325	0.467	NS
LAML	Acute Myeloid Leukemia	149	1.406	0.231	NS
LGG	Brain Lower Grade Glioma	511	1.18	0.528	NS
LIHC	Liver hepatocellular carcinoma	365	1.211	0.457	NS
LUAD	Lung adenocarcinoma	502	1.679	0.0177	Shorter
LUSC	Lung squamous cell carcinoma	494	0.842	0.367	NS
OV	Ovarian serous cystadenocarcinoma	303	1.04	0.853	NS
PAAD	Pancreatic adenocarcinoma	177	0.945	0.854	NS
PCPG	Pheochromocytoma and Paraganglioma	179	2.185	0.513	NS
PRAD	Prostate adenocarcinoma	497	2.978	0.324	NS
READ	Rectum adenocarcinoma	159	2.204	0.212	NS
SARC	Sarcoma	259	0.823	0.472	NS
SKCM	Skin Cutaneous Melanoma	459	1.807	0.00192	Shorter
STAD	Stomach adenocarcinoma	388	0.814	0.336	NS
TGCT	Testicular Germ Cell Tumors	134	0	0.0937	NS
THCA	Thyroid carcinoma	500	0.951	0.931	NS
THYM	Thymoma	119	0.175	0.0833	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	1.806	0.0463	Shorter

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	-0.038	0.444	NS
BRCA	Breast invasive carcinoma	1071	0.071	0.02	Higher
CESC	Cervical and endocervical cancers	167	0.015	0.843	NS
COAD	Colon adenocarcinoma	445	-0.075	0.113	NS
ESCA	Esophageal carcinoma	162	-0.048	0.544	NS
HNSC	Head and Neck squamous cell carcinoma	448	0.009	0.857	NS
KIRC	Kidney renal clear cell carcinoma	531	0.21	1.01e-06	Higher
KIRP	Kidney renal papillary cell carcinoma	260	0.219	0.000375	Higher
LIHC	Liver hepatocellular carcinoma	347	0.057	0.288	NS
LUAD	Lung adenocarcinoma	507	0.123	0.00572	Higher
LUSC	Lung squamous cell carcinoma	497	0.078	0.0843	NS
OV	Ovarian serous cystadenocarcinoma	302	-0.063	0.278	NS
PAAD	Pancreatic adenocarcinoma	176	-0.172	0.0222	Lower
READ	Rectum adenocarcinoma	156	-0.061	0.449	NS
SKCM	Skin Cutaneous Melanoma	410	-0.045	0.366	NS
STAD	Stomach adenocarcinoma	392	-0.074	0.144	NS
TGCT	Testicular Germ Cell Tumors	81	-0.148	0.186	NS
THCA	Thyroid carcinoma	499	0.137	0.00213	Higher
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.09	0.0431	Higher

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	0.044	0.472	NS
HNSC	Head and Neck squamous cell carcinoma	498	0.226	3.26e-07	Higher
KIRC	Kidney renal clear cell carcinoma	525	0.189	1.33e-05	Higher
LGG	Brain Lower Grade Glioma	514	0.031	0.486	NS
LIHC	Liver hepatocellular carcinoma	366	0.081	0.12	NS
OV	Ovarian serous cystadenocarcinoma	296	0.169	0.00345	Higher
PAAD	Pancreatic adenocarcinoma	176	-0.037	0.626	NS
STAD	Stomach adenocarcinoma	406	-0.084	0.09	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.358	1.36e-17	Higher

Summary
Symbol	SUV39H1
Name	suppressor of variegation 3-9 homolog 1
Aliases	KMT1A; SUV39H; suppressor of variegation 3-9 (Drosophila) homolog 1; H3-K9-HMTase 1; MG44; Su(var)3-9 homolo ......
Location	Xp11.23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	SUV39H1
Name	suppressor of variegation 3-9 homolog 1
Aliases	KMT1A; SUV39H; suppressor of variegation 3-9 (Drosophila) homolog 1; H3-K9-HMTase 1; MG44; Su(var)3-9 homolo ......
Location	Xp11.23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for SUV39H1.

Summary
Symbol	SUV39H1
Name	suppressor of variegation 3-9 homolog 1
Aliases	KMT1A; SUV39H; suppressor of variegation 3-9 (Drosophila) homolog 1; H3-K9-HMTase 1; MG44; Su(var)3-9 homolo ......
Location	Xp11.23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
24844570	Hepatocellular Carcinoma	partner	H3K9me3	correlation	Expression levels of SUV39H1 but not those of ESET were significantly correlated with H3K9me3 levels.
22991213	Hepatocellular Carcinoma	upstream	miR-125b	negative regulation	We also identified microRNA-125b (miR-125b) as a post-transcriptional regulator of SUV39H1. Our observations suggested that miR-125b down-regulation may account for the aberrant SUV39H1 level in HCC.
17657744	Colorectal Carcinoma	partner	DNMT1	positive correlation	Patients with elevated mRNA levels of SUV39H1 showed a higher prevalence of DNMT1 elevation than those without (61 vs. 35%, p = 0.0008).