CR2Cancer

Summary
Symbol	TRIM24
Name	tripartite motif containing 24
Aliases	hTIF1; Tif1a; RNF82; TIF1; transcriptional intermediary factor 1; tripartite motif-containing 24; PTC6; TF1A ......
Location	7q33-q34
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

[ TOP ]

Domain

PF00439 Bromodomain
PF00628 PHD-finger
PF00643 B-box zinc finger

Function

Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity).

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification read	#	H3K4, H3K23ac	#	22464331

> Gene Ontology [ TOP ]
Biological Process	GO:0007584 response to nutrient GO:0009991 response to extracellular stimulus GO:0018108 peptidyl-tyrosine phosphorylation GO:0018212 peptidyl-tyrosine modification GO:0030522 intracellular receptor signaling pathway GO:0031647 regulation of protein stability GO:0031667 response to nutrient levels GO:0031668 cellular response to extracellular stimulus GO:0031669 cellular response to nutrient levels GO:0031670 cellular response to nutrient GO:0032104 regulation of response to extracellular stimulus GO:0032107 regulation of response to nutrient levels GO:0033273 response to vitamin GO:0033280 response to vitamin D GO:0043434 response to peptide hormone GO:0043627 response to estrogen GO:0046777 protein autophosphorylation GO:0055074 calcium ion homeostasis GO:0070561 vitamin D receptor signaling pathway GO:0070562 regulation of vitamin D receptor signaling pathway GO:0071295 cellular response to vitamin GO:0071305 cellular response to vitamin D GO:0071391 cellular response to estrogen stimulus GO:0071396 cellular response to lipid GO:0071407 cellular response to organic cyclic compound GO:0071496 cellular response to external stimulus GO:0072331 signal transduction by p53 class mediator GO:0072507 divalent inorganic cation homeostasis GO:1901652 response to peptide GO:1901796 regulation of signal transduction by p53 class mediator
Molecular Function	GO:0002039 p53 binding GO:0003682 chromatin binding GO:0003713 transcription coactivator activity GO:0004713 protein tyrosine kinase activity GO:0004842 ubiquitin-protein transferase activity GO:0016874 ligase activity GO:0016922 ligand-dependent nuclear receptor binding GO:0019787 ubiquitin-like protein transferase activity GO:0034056 estrogen response element binding GO:0042393 histone binding GO:0061630 ubiquitin protein ligase activity GO:0061659 ubiquitin-like protein ligase activity GO:0070577 lysine-acetylated histone binding
Cellular Component	GO:0000785 chromatin GO:0000790 nuclear chromatin GO:0000791 euchromatin GO:0005719 nuclear euchromatin GO:0005726 perichromatin fibrils GO:0044454 nuclear chromosome part

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-1643685: Disease R-HSA-5663202: Diseases of signal transduction R-HSA-1839124: FGFR1 mutant receptor activation R-HSA-6802957: Oncogenic MAPK signaling R-HSA-6802952: Signaling by BRAF and RAF fusions R-HSA-1226099: Signaling by FGFR in disease R-HSA-5655302: Signaling by FGFR1 in disease R-HSA-1839117: Signaling by cytosolic FGFR1 fusion mutants

Summary
Symbol	TRIM24
Name	tripartite motif containing 24
Aliases	hTIF1; Tif1a; RNF82; TIF1; transcriptional intermediary factor 1; tripartite motif-containing 24; PTC6; TF1A ......
Location	7q33-q34
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM3633863	c.2280G>A	p.Q760Q	Substitution - coding silent	Skin
COSM5904303	c.1085T>A	p.F362Y	Substitution - Missense	Skin
COSM452425	c.831G>A	p.L277L	Substitution - coding silent	Breast
COSM1448359	c.1171C>T	p.R391C	Substitution - Missense	Skin
COSM2859923	c.2549C>A	p.A850D	Substitution - Missense	Large_intestine
COSM5807417	c.2637A>G	p.L879L	Substitution - coding silent	Liver
COSM2859871	c.1466G>A	p.S489N	Substitution - Missense	Large_intestine
COSM5997289	c.1522C>A	p.P508T	Substitution - Missense	Prostate
COSM1448372	c.1339C>T	p.P447S	Substitution - Missense	Large_intestine
COSM5805777	c.1434G>A	p.P478P	Substitution - coding silent	Liver
COSM2859783	c.258G>A	p.Q86Q	Substitution - coding silent	Large_intestine
COSM1699412	c.1315C>T	p.P439S	Substitution - Missense	Skin
COSM1699408	c.1248T>A	p.N416K	Substitution - Missense	Skin
COSM168758	c.2059C>T	p.R687*	Substitution - Nonsense	Large_intestine
COSM99027	c.1597C>T	p.P533S	Substitution - Missense	Stomach
COSM3662942	c.1995G>A	p.V665V	Substitution - coding silent	Liver
COSM166851	c.2626C>T	p.R876C	Substitution - Missense	Pancreas
COSM745476	c.1874C>T	p.P625L	Substitution - Missense	Large_intestine
COSM4654196	c.1489A>G	p.R497G	Substitution - Missense	Large_intestine
COSM2859925	c.2567delA	p.K858fs*9	Deletion - Frameshift	Large_intestine
COSM745470	c.2683G>A	p.E895K	Substitution - Missense	Lung
COSM12998	c.1208C>A	p.T403N	Substitution - Missense	Lung
COSM5582850	c.2423C>T	p.S808F	Substitution - Missense	Skin
COSM1699411	c.1315C>T	p.P439S	Substitution - Missense	Skin
COSM4155427	c.1742T>A	p.V581E	Substitution - Missense	Kidney
COSM1622397	c.2110G>A	p.A704T	Substitution - Missense	Liver
COSM3633857	c.2125G>A	p.E709K	Substitution - Missense	Skin
COSM1622393	c.329C>T	p.S110L	Substitution - Missense	Liver
COSM3922782	c.1251C>T	p.I417I	Substitution - coding silent	Skin
COSM166852	c.2728C>T	p.R910C	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4547901	c.433G>T	p.V145L	Substitution - Missense	Skin
COSM4992836	c.1803G>A	p.L601L	Substitution - coding silent	Skin
COSM5816925	c.368G>A	p.G123E	Substitution - Missense	Liver
COSM1568609	c.2053C>T	p.P685S	Substitution - Missense	Large_intestine
COSM1733224	c.2756_2758delAAG	p.E920delE	Deletion - In frame	Pancreas
COSM3662945	c.2479C>G	p.P827A	Substitution - Missense	Liver
COSM20649	c.959T>C	p.I320T	Substitution - Missense	Ovary
COSM5576172	c.706G>C	p.E236Q	Substitution - Missense	Stomach
COSM5786129	c.457A>T	p.S153C	Substitution - Missense	Breast
COSM1086002	c.2212A>G	p.T738A	Substitution - Missense	Endometrium
COSM373316	c.732A>T	p.R244R	Substitution - coding silent	Lung
COSM3633865	c.2288C>T	p.S763F	Substitution - Missense	Skin
COSM4735984	c.508G>A	p.A170T	Substitution - Missense	Large_intestine
COSM5428708	c.276C>A	p.P92P	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM5020670	c.2164C>T	p.P722S	Substitution - Missense	Skin
COSM4735989	c.1265C>A	p.S422Y	Substitution - Missense	Large_intestine
COSM5459295	c.1842A>G	p.P614P	Substitution - coding silent	Large_intestine
COSM1622394	c.329C>T	p.S110L	Substitution - Missense	Liver
COSM3762397	c.2589A>G	p.G863G	Substitution - coding silent	Soft_tissue
COSM4153870	c.833T>A	p.M278K	Substitution - Missense	Ovary
COSM3374505	c.1898C>T	p.S633F	Substitution - Missense	Thyroid
COSM4735994	c.3019_3020insA	p.R1009fs*10	Insertion - Frameshift	Large_intestine
COSM4992837	c.2760G>C	p.M920I	Substitution - Missense	Skin
COSM5904304	c.1085T>A	p.F362Y	Substitution - Missense	Skin
COSM108000	c.2676G>A	p.K892K	Substitution - coding silent	Skin
COSM3878493	c.2551C>T	p.P851S	Substitution - Missense	Stomach
COSM1471941	c.117G>A	p.P39P	Substitution - coding silent	Prostate
COSM3950012	c.1481C>G	p.P494R	Substitution - Missense	Lung
COSM2859913	c.2197A>G	p.S733G	Substitution - Missense	Large_intestine
COSM5820729	c.1872C>G	p.V624V	Substitution - coding silent	Liver
COSM5416901	c.662T>C	p.V221A	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5019655	c.2925C>T	p.N975N	Substitution - coding silent	Soft_tissue
COSM4992829	c.1594C>T	p.P532S	Substitution - Missense	Skin
COSM4637510	c.1349G>T	p.G450V	Substitution - Missense	Large_intestine
COSM4981121	c.1082A>G	p.H361R	Substitution - Missense	Oesophagus
COSM1230307	c.623T>C	p.V208A	Substitution - Missense	Large_intestine
COSM1622395	c.1912_1913insT	p.V639fs*6	Insertion - Frameshift	Liver
COSM3878483	c.819A>G	p.L273L	Substitution - coding silent	Stomach
COSM3366797	c.3141G>C	p.Q1047H	Substitution - Missense	Kidney
COSM2859922	c.2651C>A	p.A884D	Substitution - Missense	Large_intestine
COSM3762398	c.2487A>G	p.G829G	Substitution - coding silent	Soft_tissue
COSM1673581	c.2906T>G	p.F969C	Substitution - Missense	Large_intestine
COSM3942054	c.2087G>A	p.S696N	Substitution - Missense	Oesophagus
COSM5006101	c.507_508insA	p.A170fs*12	Insertion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM4587150	c.2568A>G	p.E856E	Substitution - coding silent	Bone
COSM3662941	c.1777-2A>T	p.?	Unknown	Liver
COSM5922658	c.1669C>T	p.P557S	Substitution - Missense	Skin
COSM3878477	c.194G>A	p.S65N	Substitution - Missense	Stomach
COSM1448356	c.1015C>T	p.R339C	Substitution - Missense	Large_intestine
COSM2859789	c.365-5C>T	p.?	Unknown	Skin
COSM452422	c.652C>T	p.Q218*	Substitution - Nonsense	Breast
COSM1622398	c.2008G>A	p.A670T	Substitution - Missense	Liver
COSM1673581	c.2906T>G	p.F969C	Substitution - Missense	Large_intestine
COSM1664677	c.475T>A	p.S159T	Substitution - Missense	Kidney
COSM1086000	c.1948C>T	p.R650C	Substitution - Missense	Endometrium
COSM1699412	c.1315C>T	p.P439S	Substitution - Missense	Skin
COSM452418	c.404C>G	p.A135G	Substitution - Missense	Breast
COSM452421	c.652C>T	p.Q218*	Substitution - Nonsense	Breast
COSM1330046	c.2037A>C	p.V679V	Substitution - coding silent	Ovary
COSM3633858	c.2285C>T	p.S762F	Substitution - Missense	Skin
COSM2859837	c.1152C>T	p.Y384Y	Substitution - coding silent	Large_intestine
COSM4508252	c.769C>T	p.Q257*	Substitution - Nonsense	Skin
COSM5767157	c.102G>C	p.E34D	Substitution - Missense	Breast
COSM1699409	c.1248T>A	p.N416K	Substitution - Missense	Skin
COSM24028	c.2871C>T	p.S957S	Substitution - coding silent	Breast
COSM5997288	c.1624C>A	p.P542T	Substitution - Missense	Prostate
COSM452419	c.404C>G	p.A135G	Substitution - Missense	Breast
COSM5575639	c.1927A>G	p.T643A	Substitution - Missense	Stomach
COSM1471942	c.117G>A	p.P39P	Substitution - coding silent	Prostate
COSM3662943	c.1893G>A	p.V631V	Substitution - coding silent	Liver
COSM5575640	c.1825A>G	p.T609A	Substitution - Missense	Stomach
COSM5518799	c.2537A>G	p.K846R	Substitution - Missense	Biliary_tract
COSM3878479	c.390C>T	p.C130C	Substitution - coding silent	Stomach
COSM745475	c.1887A>G	p.S629S	Substitution - coding silent	Lung
COSM1448354	c.655C>T	p.R219*	Substitution - Nonsense	Large_intestine
COSM1699411	c.1315C>T	p.P439S	Substitution - Missense	Skin
COSM4631180	c.2508C>T	p.C836C	Substitution - coding silent	Large_intestine
COSM5666745	c.517A>C	p.N173H	Substitution - Missense	Soft_tissue
COSM3715610	c.2717G>A	p.R906K	Substitution - Missense	Upper_aerodigestive_tract
COSM5020977	c.2616C>G	p.D872E	Substitution - Missense	Soft_tissue
COSM2859906	c.2252delA	p.N752fs*14	Deletion - Frameshift	Large_intestine
COSM4637167	c.1426C>T	p.Q476*	Substitution - Nonsense	Large_intestine
COSM1496503	c.2835G>C	p.L945F	Substitution - Missense	Kidney
COSM3374504	c.2000C>T	p.S667F	Substitution - Missense	Thyroid
COSM5818667	c.2859A>G	p.Q953Q	Substitution - coding silent	Liver
COSM3633862	c.2382G>A	p.Q794Q	Substitution - coding silent	Skin
COSM3922783	c.1251C>T	p.I417I	Substitution - coding silent	Skin
COSM5020669	c.2266C>T	p.P756S	Substitution - Missense	Skin
COSM4433139	c.2428T>C	p.C810R	Substitution - Missense	Oesophagus
COSM3878494	c.2995G>A	p.E999K	Substitution - Missense	Stomach
COSM745476	c.1874C>T	p.P625L	Substitution - Missense	Lung
COSM5767156	c.102G>C	p.E34D	Substitution - Missense	Breast
COSM166851	c.2626C>T	p.R876C	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3633856	c.2227G>A	p.E743K	Substitution - Missense	Skin
COSM3762398	c.2487A>G	p.G829G	Substitution - coding silent	Soft_tissue
COSM3831977	c.794A>T	p.N265I	Substitution - Missense	Breast
COSM5820728	c.1974C>G	p.V658V	Substitution - coding silent	Liver
COSM22381	c.2769C>T	p.S923S	Substitution - coding silent	Breast
COSM1173292	c.1616G>T	p.S539I	Substitution - Missense	Oesophagus
COSM4433138	c.2530T>C	p.C844R	Substitution - Missense	Oesophagus
COSM1448353	c.655C>T	p.R219*	Substitution - Nonsense	Large_intestine
COSM5560509	c.1494G>T	p.M498I	Substitution - Missense	Prostate
COSM5428708	c.276C>A	p.P92P	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM3662940	c.1879-2A>T	p.?	Unknown	Liver
COSM1230306	c.623T>C	p.V208A	Substitution - Missense	Large_intestine
COSM4735987	c.835_836insA	p.T281fs*17	Insertion - Frameshift	Large_intestine
COSM1448357	c.1015C>T	p.R339C	Substitution - Missense	Large_intestine
COSM2859867	c.1535C>T	p.P512L	Substitution - Missense	Large_intestine
COSM22381	c.2769C>T	p.S923S	Substitution - coding silent	Breast
COSM5020669	c.2266C>T	p.P756S	Substitution - Missense	Soft_tissue
COSM4735994	c.3019_3020insA	p.R1009fs*10	Insertion - Frameshift	Large_intestine
COSM5816926	c.368G>A	p.G123E	Substitution - Missense	Liver
COSM168759	c.2161C>T	p.R721*	Substitution - Nonsense	Endometrium
COSM3381814	c.1413G>C	p.Q471H	Substitution - Missense	Pancreas
COSM316131	c.2458G>C	p.V820L	Substitution - Missense	Lung
COSM22381	c.2769C>T	p.S923S	Substitution - coding silent	Skin
COSM484897	c.1559A>C	p.N520T	Substitution - Missense	Oesophagus
COSM3878492	c.2653C>T	p.P885S	Substitution - Missense	Stomach
COSM168758	c.2059C>T	p.R687*	Substitution - Nonsense	Large_intestine
COSM1085994	c.1406G>A	p.R469Q	Substitution - Missense	Endometrium
COSM216041	c.2024C>T	p.T675I	Substitution - Missense	Central_nervous_system
COSM5997291	c.1657C>A	p.P553T	Substitution - Missense	Prostate
COSM1699418	c.1981G>A	p.G661R	Substitution - Missense	Skin
COSM484900	c.2485G>T	p.G829*	Substitution - Nonsense	Kidney
COSM168758	c.2059C>T	p.R687*	Substitution - Nonsense	Large_intestine
COSM3878478	c.194G>A	p.S65N	Substitution - Missense	Stomach
COSM4161824	c.26T>G	p.V9G	Substitution - Missense	Thyroid
COSM377296	c.2719-1G>C	p.?	Unknown	Lung
COSM3662943	c.1893G>A	p.V631V	Substitution - coding silent	Biliary_tract
COSM20649	c.959T>C	p.I320T	Substitution - Missense	Ovary
COSM1622398	c.2008G>A	p.A670T	Substitution - Missense	Liver
COSM2859870	c.1568G>A	p.S523N	Substitution - Missense	Large_intestine
COSM4393846	c.1191C>T	p.S397S	Substitution - coding silent	Skin
COSM88015	c.2925G>T	p.R975S	Substitution - Missense	Central_nervous_system
COSM1622396	c.1810_1811insT	p.V605fs*6	Insertion - Frameshift	Liver
COSM316131	c.2458G>C	p.V820L	Substitution - Missense	Soft_tissue
COSM1085995	c.1406G>A	p.R469Q	Substitution - Missense	Endometrium
COSM5358111	c.767A>G	p.Y256C	Substitution - Missense	Large_intestine
COSM373315	c.732A>T	p.R244R	Substitution - coding silent	Lung
COSM2859838	c.1152C>T	p.Y384Y	Substitution - coding silent	Large_intestine
COSM484896	c.1661A>C	p.N554T	Substitution - Missense	Oesophagus
COSM5416902	c.662T>C	p.V221A	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1330047	c.1935A>C	p.V645V	Substitution - coding silent	Ovary
COSM377297	c.2617-1G>C	p.?	Unknown	Lung
COSM3927846	c.1588C>A	p.Q530K	Substitution - Missense	Prostate
COSM5787756	c.1603-10G>A	p.?	Unknown	Breast
COSM484901	c.2596A>C	p.I866L	Substitution - Missense	Kidney
COSM334759	c.676C>G	p.H226D	Substitution - Missense	Lung
COSM1448360	c.1171C>T	p.R391C	Substitution - Missense	Skin
COSM3633867	c.3004C>T	p.R1002W	Substitution - Missense	Skin
COSM129890	c.3029T>G	p.F1010C	Substitution - Missense	Upper_aerodigestive_tract
COSM166851	c.2626C>T	p.R876C	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM249224	c.2965A>C	p.K989Q	Substitution - Missense	Kidney
COSM484899	c.2587G>T	p.G863*	Substitution - Nonsense	Kidney
COSM5976233	c.1289G>A	p.S430N	Substitution - Missense	Upper_aerodigestive_tract
COSM249225	c.3067A>C	p.K1023Q	Substitution - Missense	Kidney
COSM3715611	c.2615G>A	p.R872K	Substitution - Missense	Upper_aerodigestive_tract
COSM1699417	c.2083G>A	p.G695R	Substitution - Missense	Skin
COSM5576260	c.3115C>T	p.R1039C	Substitution - Missense	Stomach
COSM166852	c.2728C>T	p.R910C	Substitution - Missense	Large_intestine
COSM1085991	c.1296A>G	p.P432P	Substitution - coding silent	Endometrium
COSM1085992	c.1296A>G	p.P432P	Substitution - coding silent	Endometrium
COSM1179206	c.2502C>T	p.N834N	Substitution - coding silent	Prostate
COSM3633860	c.2312C>T	p.S771F	Substitution - Missense	Skin
COSM4974440	c.2866G>A	p.G956S	Substitution - Missense	Oesophagus
COSM3878480	c.390C>T	p.C130C	Substitution - coding silent	Stomach
COSM3831978	c.794A>T	p.N265I	Substitution - Missense	Breast
COSM3662944	c.2581C>G	p.P861A	Substitution - Missense	Liver
COSM3633859	c.2183C>T	p.S728F	Substitution - Missense	Skin
COSM3662944	c.2581C>G	p.P861A	Substitution - Missense	Liver
COSM4992833	c.1562C>T	p.P521L	Substitution - Missense	Skin
COSM2859782	c.258G>A	p.Q86Q	Substitution - coding silent	Large_intestine
COSM5734045	c.2986G>A	p.D996N	Substitution - Missense	Pancreas
COSM377732	c.532G>C	p.E178Q	Substitution - Missense	Lung
COSM136636	c.574C>T	p.Q192*	Substitution - Nonsense	Skin
COSM3633849	c.1377C>T	p.F459F	Substitution - coding silent	Skin
COSM5666744	c.517A>C	p.N173H	Substitution - Missense	Soft_tissue
COSM5818668	c.2757A>G	p.Q919Q	Substitution - coding silent	Liver
COSM1166732	c.2754T>A	p.H918Q	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3878497	c.3035G>A	p.R1012H	Substitution - Missense	Stomach
COSM5020978	c.2514C>G	p.D838E	Substitution - Missense	Soft_tissue
COSM5476733	c.2082A>G	p.R694R	Substitution - coding silent	Large_intestine
COSM2150337	c.1172G>A	p.R391H	Substitution - Missense	Central_nervous_system
COSM2859907	c.2150delA	p.N718fs*14	Deletion - Frameshift	Large_intestine
COSM2859912	c.2299A>G	p.S767G	Substitution - Missense	Large_intestine
COSM5976232	c.1289G>A	p.S430N	Substitution - Missense	Upper_aerodigestive_tract
COSM287591	c.3104C>T	p.P1035L	Substitution - Missense	Large_intestine
COSM1622393	c.329C>T	p.S110L	Substitution - Missense	Liver
COSM3831985	c.3127A>G	p.I1043V	Substitution - Missense	Breast
COSM3633845	c.436A>C	p.K146Q	Substitution - Missense	Skin
COSM5005771	c.1056C>G	p.L352L	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM4806625	c.733G>T	p.D245Y	Substitution - Missense	Pancreas
COSM2859865	c.1492A>C	p.M498L	Substitution - Missense	Upper_aerodigestive_tract
COSM4554358	c.619G>A	p.E207K	Substitution - Missense	Skin
COSM1448371	c.1339C>T	p.P447S	Substitution - Missense	Large_intestine
COSM5428709	c.276C>A	p.P92P	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM216042	c.2126C>T	p.T709I	Substitution - Missense	Central_nervous_system
COSM3762397	c.2589A>G	p.G863G	Substitution - coding silent	Soft_tissue
COSM166852	c.2728C>T	p.R910C	Substitution - Missense	Pancreas
COSM484896	c.1661A>C	p.N554T	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3633852	c.1378C>T	p.P460S	Substitution - Missense	Skin
COSM1496504	c.2733G>C	p.L911F	Substitution - Missense	Kidney
COSM4587147	c.1601A>G	p.Q534R	Substitution - Missense	Bone
COSM4928462	c.1457G>A	p.R486Q	Substitution - Missense	Liver
COSM129887	c.2218G>C	p.E740Q	Substitution - Missense	Upper_aerodigestive_tract
COSM4992830	c.1492C>T	p.P498S	Substitution - Missense	Skin
COSM2859868	c.1433C>T	p.P478L	Substitution - Missense	Skin
COSM5637706	c.1429-1G>T	p.?	Unknown	Oesophagus
COSM3831983	c.3001C>G	p.L1001V	Substitution - Missense	Breast
COSM1085999	c.2050C>T	p.R684C	Substitution - Missense	Endometrium
COSM4974439	c.2968G>A	p.G990S	Substitution - Missense	Oesophagus
COSM4992829	c.1594C>T	p.P532S	Substitution - Missense	Skin
COSM3633846	c.436A>C	p.K146Q	Substitution - Missense	Skin
COSM165125	c.2505C>G	p.F835L	Substitution - Missense	Breast
COSM3762397	c.2589A>G	p.G863G	Substitution - coding silent	Soft_tissue
COSM1448368	c.1275C>T	p.I425I	Substitution - coding silent	Large_intestine
COSM3366798	c.3039G>C	p.Q1013H	Substitution - Missense	Kidney
COSM76814	c.3006G>C	p.K1002N	Substitution - Missense	Ovary
COSM277800	c.376C>T	p.R126C	Substitution - Missense	Skin
COSM1448360	c.1171C>T	p.R391C	Substitution - Missense	Skin
COSM5787755	c.1705-10G>A	p.?	Unknown	Breast
COSM271571	c.2531G>A	p.C844Y	Substitution - Missense	Large_intestine
COSM3878485	c.1016G>A	p.R339H	Substitution - Missense	Stomach
COSM4393845	c.1191C>T	p.S397S	Substitution - coding silent	Skin
COSM1744615	c.903T>C	p.N301N	Substitution - coding silent	Biliary_tract
COSM1179207	c.2400C>T	p.N800N	Substitution - coding silent	Prostate
COSM2859868	c.1433C>T	p.P478L	Substitution - Missense	Large_intestine
COSM5605178	c.2571G>A	p.L857L	Substitution - coding silent	Skin
COSM4735990	c.1265C>A	p.S422Y	Substitution - Missense	Large_intestine
COSM5358111	c.767A>G	p.Y256C	Substitution - Missense	Large_intestine
COSM277801	c.376C>T	p.R126C	Substitution - Missense	Large_intestine
COSM316132	c.2560G>C	p.V854L	Substitution - Missense	Soft_tissue
COSM4768836	c.3003C>T	p.P1001P	Substitution - coding silent	Biliary_tract
COSM277801	c.376C>T	p.R126C	Substitution - Missense	Skin
COSM76813	c.2904G>C	p.K968N	Substitution - Missense	Ovary
COSM3831980	c.1598C>A	p.P533H	Substitution - Missense	Breast
COSM2150337	c.1172G>A	p.R391H	Substitution - Missense	Central_nervous_system
COSM3927845	c.1690C>A	p.Q564K	Substitution - Missense	Prostate
COSM3762398	c.2487A>G	p.G829G	Substitution - coding silent	Soft_tissue
COSM372007	c.1583G>A	p.G528E	Substitution - Missense	Lung
COSM4153870	c.833T>A	p.M278K	Substitution - Missense	Ovary
COSM5786128	c.457A>T	p.S153C	Substitution - Missense	Breast
COSM1699414	c.1334C>T	p.S445L	Substitution - Missense	Skin
COSM484897	c.1559A>C	p.N520T	Substitution - Missense	Kidney
COSM484902	c.2494A>C	p.I832L	Substitution - Missense	Kidney
COSM303446	c.1461G>C	p.R487S	Substitution - Missense	Central_nervous_system
COSM3633854	c.1754C>T	p.S585F	Substitution - Missense	Skin
COSM745477	c.1772C>T	p.P591L	Substitution - Missense	Large_intestine
COSM1699415	c.1334C>T	p.S445L	Substitution - Missense	Skin
COSM5637705	c.1531-1G>T	p.?	Unknown	Oesophagus
COSM3878486	c.1016G>A	p.R339H	Substitution - Missense	Stomach
COSM745477	c.1772C>T	p.P591L	Substitution - Missense	Lung
COSM1448350	c.641G>T	p.G214V	Substitution - Missense	Large_intestine
COSM2859907	c.2150delA	p.N718fs*14	Deletion - Frameshift	Large_intestine
COSM88016	c.3027G>T	p.R1009S	Substitution - Missense	Central_nervous_system
COSM3633866	c.3106C>T	p.R1036W	Substitution - Missense	Skin
COSM165126	c.2607C>G	p.F869L	Substitution - Missense	Breast
COSM2859874	c.1494T>A	p.P498P	Substitution - coding silent	Large_intestine
COSM4735993	c.1509G>C	p.Q503H	Substitution - Missense	Large_intestine
COSM5487572	c.2627G>T	p.R876L	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3762397	c.2589A>G	p.G863G	Substitution - coding silent	Soft_tissue
COSM12998	c.1208C>A	p.T403N	Substitution - Missense	Lung
COSM5922657	c.1771C>T	p.P591S	Substitution - Missense	Skin
COSM1673582	c.2804T>G	p.F935C	Substitution - Missense	Large_intestine
COSM1181036	c.2531_2532insC	p.K846fs*30	Insertion - Frameshift	Large_intestine
COSM326753	c.706G>A	p.E236K	Substitution - Missense	Lung
COSM5487571	c.2729G>T	p.R910L	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1085997	c.1775C>T	p.T592M	Substitution - Missense	Endometrium
COSM5019656	c.2823C>T	p.N941N	Substitution - coding silent	Soft_tissue
COSM5734044	c.3088G>A	p.D1030N	Substitution - Missense	Pancreas
COSM3662945	c.2479C>G	p.P827A	Substitution - Missense	Liver
COSM1622394	c.329C>T	p.S110L	Substitution - Missense	Liver
COSM5430871	c.2478G>A	p.E826E	Substitution - coding silent	Oesophagus
COSM1733223	c.2858_2860delAAG	p.E954delE	Deletion - In frame	Pancreas
COSM3633851	c.1378C>T	p.P460S	Substitution - Missense	Skin
COSM452424	c.831G>A	p.L277L	Substitution - coding silent	Breast
COSM3878486	c.1016G>A	p.R339H	Substitution - Missense	Large_intestine
COSM4777803	c.1213_1214insC	p.Q405fs*5	Insertion - Frameshift	Prostate
COSM4587146	c.1703A>G	p.Q568R	Substitution - Missense	Bone
COSM129885	c.808A>G	p.I270V	Substitution - Missense	Upper_aerodigestive_tract
COSM4547900	c.433G>T	p.V145L	Substitution - Missense	Skin
COSM4807122	c.374T>C	p.I125T	Substitution - Missense	Pancreas
COSM168759	c.2161C>T	p.R721*	Substitution - Nonsense	Large_intestine
COSM5593574	c.2603C>T	p.P868L	Substitution - Missense	Skin
COSM2859924	c.2669delA	p.K892fs*9	Deletion - Frameshift	Large_intestine
COSM3878488	c.1500G>A	p.G500G	Substitution - coding silent	Stomach
COSM5422922	c.2764T>G	p.Y922D	Substitution - Missense	Prostate
COSM3831984	c.2899C>G	p.L967V	Substitution - Missense	Breast
COSM4538130	c.2504G>A	p.G835E	Substitution - Missense	Skin
COSM5582851	c.2321C>T	p.S774F	Substitution - Missense	Skin
COSM4161823	c.26T>G	p.V9G	Substitution - Missense	Thyroid
COSM3762397	c.2589A>G	p.G863G	Substitution - coding silent	Soft_tissue
COSM107999	c.2574G>A	p.K858K	Substitution - coding silent	Skin
COSM2859906	c.2252delA	p.N752fs*14	Deletion - Frameshift	Large_intestine
COSM4992839	c.2940T>C	p.N980N	Substitution - coding silent	Skin
COSM2859867	c.1535C>T	p.P512L	Substitution - Missense	Skin
COSM3662940	c.1879-2A>T	p.?	Unknown	Liver
COSM166852	c.2728C>T	p.R910C	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3995373	c.141G>A	p.A47A	Substitution - coding silent	Kidney
COSM129886	c.808A>G	p.I270V	Substitution - Missense	Upper_aerodigestive_tract
COSM4992838	c.2658G>C	p.M886I	Substitution - Missense	Skin
COSM5593573	c.2705C>T	p.P902L	Substitution - Missense	Skin
COSM484897	c.1559A>C	p.N520T	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3381815	c.1413G>C	p.Q471H	Substitution - Missense	Pancreas
COSM5777256	c.1416T>C	p.H472H	Substitution - coding silent	Breast
COSM277800	c.376C>T	p.R126C	Substitution - Missense	Large_intestine
COSM3662943	c.1893G>A	p.V631V	Substitution - coding silent	Liver
COSM5576261	c.3013C>T	p.R1005C	Substitution - Missense	Stomach
COSM3831981	c.1496C>A	p.P499H	Substitution - Missense	Breast
COSM334758	c.676C>G	p.H226D	Substitution - Missense	Lung
COSM166851	c.2626C>T	p.R876C	Substitution - Missense	Large_intestine
COSM5805776	c.1536G>A	p.P512P	Substitution - coding silent	Liver
COSM249225	c.3067A>C	p.K1023Q	Substitution - Missense	Kidney
COSM3762397	c.2589A>G	p.G863G	Substitution - coding silent	Large_intestine
COSM136637	c.574C>T	p.Q192*	Substitution - Nonsense	Skin
COSM376122	c.2078G>T	p.S693I	Substitution - Missense	Lung
COSM5422921	c.2866T>G	p.Y956D	Substitution - Missense	Prostate
COSM316132	c.2560G>C	p.V854L	Substitution - Missense	Lung
COSM5605179	c.2469G>A	p.L823L	Substitution - coding silent	Skin
COSM3633852	c.1378C>T	p.P460S	Substitution - Missense	Skin
COSM1448359	c.1171C>T	p.R391C	Substitution - Missense	Skin
COSM4981122	c.1082A>G	p.H361R	Substitution - Missense	Oesophagus
COSM5006100	c.507_508insA	p.A170fs*12	Insertion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM1622397	c.2110G>A	p.A704T	Substitution - Missense	Liver
COSM4777804	c.1213_1214insC	p.Q405fs*5	Insertion - Frameshift	Prostate
COSM1664676	c.475T>A	p.S159T	Substitution - Missense	Kidney
COSM5020670	c.2164C>T	p.P722S	Substitution - Missense	Soft_tissue
COSM3633864	c.2390C>T	p.S797F	Substitution - Missense	Skin
COSM4992832	c.1664C>T	p.P555L	Substitution - Missense	Skin
COSM5688139	c.1646G>T	p.S549I	Substitution - Missense	Soft_tissue
COSM4735983	c.508G>A	p.A170T	Substitution - Missense	Large_intestine
COSM168759	c.2161C>T	p.R721*	Substitution - Nonsense	Large_intestine
COSM5518800	c.2435A>G	p.K812R	Substitution - Missense	Biliary_tract
COSM5997292	c.1555C>A	p.P519T	Substitution - Missense	Prostate
COSM5005770	c.1056C>G	p.L352L	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM5358112	c.767A>G	p.Y256C	Substitution - Missense	Large_intestine
COSM3662942	c.1995G>A	p.V665V	Substitution - coding silent	Biliary_tract
COSM4992835	c.1905G>A	p.L635L	Substitution - coding silent	Skin
COSM4153871	c.833T>A	p.M278K	Substitution - Missense	Ovary
COSM5576173	c.706G>C	p.E236Q	Substitution - Missense	Stomach
COSM168759	c.2161C>T	p.R721*	Substitution - Nonsense	Large_intestine
COSM1744614	c.903T>C	p.N301N	Substitution - coding silent	Biliary_tract
COSM24028	c.2871C>T	p.S957S	Substitution - coding silent	Skin
COSM3878485	c.1016G>A	p.R339H	Substitution - Missense	Large_intestine
COSM745471	c.2581G>A	p.E861K	Substitution - Missense	Lung
COSM35821	c.1172G>A	p.R391H	Substitution - Missense	Central_nervous_system
COSM745474	c.1989A>G	p.S663S	Substitution - coding silent	Lung
COSM2859780	c.150C>G	p.L50L	Substitution - coding silent	Bone
COSM3995374	c.141G>A	p.A47A	Substitution - coding silent	Kidney
COSM745477	c.1772C>T	p.P591L	Substitution - Missense	Skin
COSM3878496	c.3137G>A	p.R1046H	Substitution - Missense	Stomach
COSM3878482	c.819A>G	p.L273L	Substitution - coding silent	Stomach
COSM4155426	c.1844T>A	p.V615E	Substitution - Missense	Kidney
COSM5430872	c.2376G>A	p.E792E	Substitution - coding silent	Oesophagus
COSM5358112	c.767A>G	p.Y256C	Substitution - Missense	Large_intestine
COSM4770775	c.3055_3058delTCAG	p.S1019fs*>31	Deletion - Frameshift	Pleura
COSM5476734	c.1980A>G	p.R660R	Substitution - coding silent	Large_intestine
COSM4992830	c.1492C>T	p.P498S	Substitution - Missense	Skin
COSM5428709	c.276C>A	p.P92P	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM4637168	c.1426C>T	p.Q476*	Substitution - Nonsense	Large_intestine
COSM1173291	c.1718G>T	p.S573I	Substitution - Missense	Oesophagus
COSM484896	c.1661A>C	p.N554T	Substitution - Missense	Kidney
COSM372008	c.1481G>A	p.G494E	Substitution - Missense	Lung
COSM271570	c.2429G>A	p.C810Y	Substitution - Missense	Large_intestine
COSM3633861	c.2210C>T	p.S737F	Substitution - Missense	Skin
COSM4153871	c.833T>A	p.M278K	Substitution - Missense	Ovary
COSM5688138	c.1748G>T	p.S583I	Substitution - Missense	Soft_tissue
COSM22381	c.2769C>T	p.S923S	Substitution - coding silent	Breast
COSM326754	c.706G>A	p.E236K	Substitution - Missense	Lung
COSM3633848	c.1377C>T	p.F459F	Substitution - coding silent	Skin
COSM3928840	c.2830G>A	p.E944K	Substitution - Missense	Central_nervous_system
COSM3715610	c.2717G>A	p.R906K	Substitution - Missense	Upper_aerodigestive_tract
COSM1673582	c.2804T>G	p.F935C	Substitution - Missense	Large_intestine
COSM377731	c.532G>C	p.E178Q	Substitution - Missense	Lung
COSM3928839	c.2932G>A	p.E978K	Substitution - Missense	Central_nervous_system
COSM35821	c.1172G>A	p.R391H	Substitution - Missense	Central_nervous_system
COSM2859781	c.150C>G	p.L50L	Substitution - coding silent	Bone
COSM5738178	c.2507G>A	p.C836Y	Substitution - Missense	Small_intestine
COSM745476	c.1874C>T	p.P625L	Substitution - Missense	Skin
COSM5406605	c.632-1G>A	p.?	Unknown	Skin
COSM3662941	c.1777-2A>T	p.?	Unknown	Liver
COSM95398	c.2017G>C	p.D673H	Substitution - Missense	Ovary
COSM3831986	c.3025A>G	p.I1009V	Substitution - Missense	Breast
COSM5487571	c.2729G>T	p.R910L	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3633851	c.1378C>T	p.P460S	Substitution - Missense	Skin
COSM287590	c.3002C>T	p.P1001L	Substitution - Missense	Large_intestine
COSM129888	c.2320G>C	p.E774Q	Substitution - Missense	Upper_aerodigestive_tract
COSM5777255	c.1416T>C	p.H472H	Substitution - coding silent	Breast
COSM2859873	c.1596T>A	p.P532P	Substitution - coding silent	Large_intestine
COSM249224	c.2965A>C	p.K989Q	Substitution - Missense	Kidney
COSM4807121	c.374T>C	p.I125T	Substitution - Missense	Pancreas
COSM168758	c.2059C>T	p.R687*	Substitution - Nonsense	Endometrium
COSM5406606	c.632-1G>A	p.?	Unknown	Skin
COSM4637511	c.1349G>T	p.G450V	Substitution - Missense	Large_intestine
COSM5459296	c.1740A>G	p.P580P	Substitution - coding silent	Large_intestine
COSM4770776	c.2953_2956delTCAG	p.S985fs*>31	Deletion - Frameshift	Pleura
COSM3878490	c.1574C>T	p.A525V	Substitution - Missense	Stomach
COSM3762398	c.2487A>G	p.G829G	Substitution - coding silent	Soft_tissue
COSM3942055	c.1985G>A	p.S662N	Substitution - Missense	Oesophagus
COSM4902487	c.1476T>C	p.G492G	Substitution - coding silent	Skin
COSM3762397	c.2589A>G	p.G863G	Substitution - coding silent	Soft_tissue
COSM3762398	c.2487A>G	p.G829G	Substitution - coding silent	Large_intestine
COSM4735986	c.835_836insA	p.T281fs*17	Insertion - Frameshift	Large_intestine
COSM1085998	c.1673C>T	p.T558M	Substitution - Missense	Endometrium
COSM4735995	c.2917_2918insA	p.R975fs*10	Insertion - Frameshift	Large_intestine
COSM5807416	c.2739A>G	p.L913L	Substitution - coding silent	Liver
COSM5487572	c.2627G>T	p.R876L	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3878495	c.2893G>A	p.E965K	Substitution - Missense	Stomach
COSM4735992	c.1455A>G	p.Q485Q	Substitution - coding silent	Large_intestine
COSM3715611	c.2615G>A	p.R872K	Substitution - Missense	Upper_aerodigestive_tract
COSM376123	c.1976G>T	p.S659I	Substitution - Missense	Lung
COSM3762398	c.2487A>G	p.G829G	Substitution - coding silent	Soft_tissue
COSM1448369	c.1275C>T	p.I425I	Substitution - coding silent	Large_intestine
COSM4587149	c.2670A>G	p.E890E	Substitution - coding silent	Bone
COSM3762397	c.2589A>G	p.G863G	Substitution - coding silent	Soft_tissue
COSM3878489	c.1676C>T	p.A559V	Substitution - Missense	Stomach
COSM5738177	c.2609G>A	p.C870Y	Substitution - Missense	Small_intestine
COSM3633855	c.1652C>T	p.S551F	Substitution - Missense	Skin
COSM4538131	c.2402G>A	p.G801E	Substitution - Missense	Skin
COSM1448351	c.641G>T	p.G214V	Substitution - Missense	Large_intestine
COSM95399	c.2119G>C	p.D707H	Substitution - Missense	Ovary
COSM129889	c.2927T>G	p.F976C	Substitution - Missense	Upper_aerodigestive_tract
COSM4508253	c.769C>T	p.Q257*	Substitution - Nonsense	Skin
COSM3662942	c.1995G>A	p.V665V	Substitution - coding silent	Liver
COSM4631179	c.2610C>T	p.C870C	Substitution - coding silent	Large_intestine
COSM3762398	c.2487A>G	p.G829G	Substitution - coding silent	Soft_tissue
COSM4806626	c.733G>T	p.D245Y	Substitution - Missense	Pancreas
COSM1166733	c.2652T>A	p.H884Q	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4768835	c.3105C>T	p.P1035P	Substitution - coding silent	Biliary_tract
COSM2859790	c.365-5C>T	p.?	Unknown	Skin
COSM4735995	c.2917_2918insA	p.R975fs*10	Insertion - Frameshift	Large_intestine
COSM4554357	c.619G>A	p.E207K	Substitution - Missense	Skin
COSM1568608	c.2155C>T	p.P719S	Substitution - Missense	Large_intestine
COSM99026	c.1495C>T	p.P499S	Substitution - Missense	Stomach
COSM4992840	c.2838T>C	p.N946N	Substitution - coding silent	Skin
COSM1086001	c.2314A>G	p.T772A	Substitution - Missense	Endometrium
COSM1181037	c.2429_2430insC	p.K812fs*30	Insertion - Frameshift	Large_intestine
COSM3762398	c.2487A>G	p.G829G	Substitution - coding silent	Soft_tissue

> Text Mining based Variations

[ TOP ]

PMID	Variation	Cancer	Evidence
24345920	mutation	Melanoma	NGS data analysis of 51 additional melanomas revealed a second BRAF fusion (TRIM24-BRAF) in a pan-negative sample; MAPK signaling induced by TRIM24-BRAF was also MEK inhibitor sensitive.

Summary
Symbol	TRIM24
Name	tripartite motif containing 24
Aliases	hTIF1; Tif1a; RNF82; TIF1; transcriptional intermediary factor 1; tripartite motif-containing 24; PTC6; TF1A ......
Location	7q33-q34
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

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Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
O15164	110	S	Phosphoserine	-	No	None detected
O15164	469	R	Omega-N-methylarginine	-	Yes	p.R469W (cancer: PAAD); p.R469Q (cancer: UCEC)
O15164	654	S	Phosphoserine	-	No	None detected
O15164	660	S	Phosphoserine	-	No	None detected
O15164	667	S	Phosphoserine	-	Yes	p.S667F (cancer: THCA)
O15164	744	S	Phosphoserine	-	No	None detected
O15164	768	S	Phosphoserine	-	No	None detected
O15164	808	S	Phosphoserine	-	No	None detected
O15164	811	S	Phosphoserine	-	No	None detected
O15164	818	T	Phosphothreonine	-	No	None detected
O15164	1019	S	Phosphoserine	-	No	None detected
O15164	1025	S	Phosphoserine	-	No	None detected
O15164	1028	S	Phosphoserine	-	No	None detected
O15164	1042	S	Phosphoserine	-	No	None detected

Summary
Symbol	TRIM24
Name	tripartite motif containing 24
Aliases	hTIF1; Tif1a; RNF82; TIF1; transcriptional intermediary factor 1; tripartite motif-containing 24; PTC6; TF1A ......
Location	7q33-q34
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

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Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	5.155	5.91	0.774	0.0075	Over
BRCA	Breast invasive carcinoma	112	1100	5.127	5.519	0.453	2.96e-14	NS
CESC	Cervical and endocervical cancers	3	306	4.334	4.898	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	4.737	5.426	0.603	6.76e-10	Over
ESCA	Esophageal carcinoma	11	185	5.584	5.37	-0.101	0.765	NS
GBM	Glioblastoma multiforme	5	166	4.947	6.189	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	4.91	4.324	-0.507	3.57e-05	NS
KIRC	Kidney renal clear cell carcinoma	72	534	4.881	4.603	-0.271	4.44e-07	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	4.599	4.695	0.128	0.317	NS
LAML	Acute Myeloid Leukemia	0	173	NA	6.77	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	5.869	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	4.995	5.369	0.409	0.000406	NS
LUAD	Lung adenocarcinoma	59	517	5.061	5.483	0.464	1.66e-06	NS
LUSC	Lung squamous cell carcinoma	51	501	4.878	5.369	0.461	4.91e-05	NS
OV	Ovarian serous cystadenocarcinoma	0	307	NA	5.319	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	4.329	4.411	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	6.33	4.645	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	5.222	5.503	0.363	4.19e-06	NS
READ	Rectum adenocarcinoma	10	167	4.43	5.459	0.902	3.33e-05	Over
SARC	Sarcoma	2	263	4.226	4.721	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	4.347	4.761	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	5.238	5.749	0.587	0.000161	Over
TGCT	Testicular Germ Cell Tumors	0	156	NA	6.067	NA	NA	NA
THCA	Thyroid carcinoma	59	509	4.463	4.7	0.28	4.78e-06	NS
THYM	Thymoma	2	120	5.351	5.31	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	4.624	5.126	0.434	3.51e-05	NS

> Cancer Cell Line Encyclopedia (CCLE)

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Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	10.9
Autonomic ganglia	CHP212	10.5
Autonomic ganglia	IMR32	10.6
Autonomic ganglia	KELLY	11.4
Autonomic ganglia	KPNRTBM1	11.3
Autonomic ganglia	KPNSI9S	10.2
Autonomic ganglia	KPNYN	11.2
Autonomic ganglia	MHHNB11	10.3
Autonomic ganglia	NB1	10.4
Autonomic ganglia	NH6	11.2
Autonomic ganglia	SHSY5Y	11.3
Autonomic ganglia	SIMA	9.9
Autonomic ganglia	SKNAS	11.3
Autonomic ganglia	SKNBE2	11.5
Autonomic ganglia	SKNDZ	10.8
Autonomic ganglia	SKNFI	9.9
Autonomic ganglia	SKNSH	10.6
Biliary tract	HUCCT1	9.4
Biliary tract	HUH28	10
Biliary tract	SNU1079	9.1
Biliary tract	SNU1196	9.1
Biliary tract	SNU245	10.4
Biliary tract	SNU308	8.6
Biliary tract	SNU478	9.5
Bone	143B	8.6
Bone	A673	9.2
Bone	CADOES1	10.4
Bone	CAL78	8.9
Bone	G292CLONEA141B1	9.5
Bone	HOS	9.2
Bone	HS706T	9.2
Bone	HS737T	8
Bone	HS819T	7.9
Bone	HS821T	7.8
Bone	HS822T	7.7
Bone	HS863T	7.9
Bone	HS870T	8.3
Bone	HS888T	8.4
Bone	MG63	8.8
Bone	MHHES1	9.4
Bone	OUMS27	8.6
Bone	RDES	9.1
Bone	SJSA1	9.3
Bone	SKES1	9.6
Bone	SKNMC	8.8
Bone	SW1353	9.7
Bone	T173	8.2
Bone	TC71	8.9
Bone	U2OS	8.9
Breast	AU565	9.5
Breast	BT20	10
Breast	BT474	10.6
Breast	BT483	10.5
Breast	BT549	8.5
Breast	CAL120	8.4
Breast	CAL148	10.5
Breast	CAL51	9.4
Breast	CAL851	8.7
Breast	CAMA1	11.4
Breast	DU4475	11
Breast	EFM192A	9.7
Breast	EFM19	9.7
Breast	EVSAT	10.1
Breast	HCC1143	9.1
Breast	HCC1187	11.1
Breast	HCC1395	10.2
Breast	HCC1419	9
Breast	HCC1428	10.4
Breast	HCC1500	10.5
Breast	HCC1569	9.3
Breast	HCC1599	9.7
Breast	HCC1806	8.3
Breast	HCC1937	8.5
Breast	HCC1954	10.1
Breast	HCC202	11.1
Breast	HCC2157	9.8
Breast	HCC2218	10.4
Breast	HCC38	10.6
Breast	HCC70	9.2
Breast	HDQP1	8.9
Breast	HMC18	8.5
Breast	HS274T	7.9
Breast	HS281T	8.1
Breast	HS343T	8.2
Breast	HS578T	9
Breast	HS606T	8
Breast	HS739T	8.1
Breast	HS742T	7.3
Breast	JIMT1	9.2
Breast	KPL1	10.1
Breast	MCF7	10
Breast	MDAMB134VI	10.8
Breast	MDAMB157	10.1
Breast	MDAMB175VII	10
Breast	MDAMB231	9.8
Breast	MDAMB361	9
Breast	MDAMB415	9.3
Breast	MDAMB436	9.4
Breast	MDAMB453	9.5
Breast	MDAMB468	9.7
Breast	SKBR3	9.2
Breast	T47D	9.2
Breast	UACC812	9.7
Breast	UACC893	9.6
Breast	YMB1	9.6
Breast	ZR751	9.1
Breast	ZR7530	9.2
Central nervous system	1321N1	9.7
Central nervous system	42MGBA	8.5
Central nervous system	8MGBA	9.3
Central nervous system	A172	9.1
Central nervous system	AM38	9.3
Central nervous system	BECKER	9.5
Central nervous system	CAS1	8.8
Central nervous system	CCFSTTG1	9.9
Central nervous system	D283MED	8.6
Central nervous system	D341MED	9.7
Central nervous system	DAOY	8.7
Central nervous system	DBTRG05MG	9
Central nervous system	DKMG	9.4
Central nervous system	GAMG	9.7
Central nervous system	GB1	9.5
Central nervous system	GI1	9.6
Central nervous system	GMS10	8.5
Central nervous system	GOS3	9.2
Central nervous system	H4	9.1
Central nervous system	HS683	9.5
Central nervous system	KALS1	9.5
Central nervous system	KG1C	9.8
Central nervous system	KNS42	10
Central nervous system	KNS60	9.2
Central nervous system	KNS81	9.3
Central nervous system	KS1	9.3
Central nervous system	LN18	9.3
Central nervous system	LN229	9.6
Central nervous system	M059K	8.9
Central nervous system	MOGGCCM	9.6
Central nervous system	MOGGUVW	9.3
Central nervous system	NMCG1	9.2
Central nervous system	ONS76	9.2
Central nervous system	SF126	8.9
Central nervous system	SF295	9.5
Central nervous system	SNB19	10.2
Central nervous system	SNU1105	8.9
Central nervous system	SNU201	8.8
Central nervous system	SNU466	9.8
Central nervous system	SNU489	8.6
Central nervous system	SNU626	9.5
Central nervous system	SNU738	9.2
Central nervous system	SW1088	9.6
Central nervous system	SW1783	9.6
Central nervous system	T98G	8.7
Central nervous system	TM31	9.8
Central nervous system	U118MG	8
Central nervous system	U138MG	8.8
Central nervous system	U251MG	10.1
Central nervous system	U87MG	9
Central nervous system	YH13	8.8
Central nervous system	YKG1	10.2
Endometrium	AN3CA	10.3
Endometrium	COLO684	10.4
Endometrium	EFE184	8.1
Endometrium	EN	9.5
Endometrium	ESS1	7.6
Endometrium	HEC108	8.7
Endometrium	HEC151	9.1
Endometrium	HEC1A	9.2
Endometrium	HEC1B	9.3
Endometrium	HEC251	9.2
Endometrium	HEC265	8.9
Endometrium	HEC50B	10.6
Endometrium	HEC59	10.3
Endometrium	HEC6	10.1
Endometrium	ISHIKAWAHERAKLIO02ER	9.3
Endometrium	JHUEM1	8.5
Endometrium	JHUEM2	9.7
Endometrium	JHUEM3	8.8
Endometrium	KLE	9.3
Endometrium	MFE280	8.9
Endometrium	MFE296	9.6
Endometrium	MFE319	8.3
Endometrium	RL952	9.7
Endometrium	SNGM	9.9
Endometrium	SNU1077	9.3
Endometrium	SNU685	8.2
Endometrium	TEN	9.5
Haematopoietic and lymphoid	697	10.2
Haematopoietic and lymphoid	A3KAW	9.2
Haematopoietic and lymphoid	A4FUK	10.2
Haematopoietic and lymphoid	ALLSIL	10.4
Haematopoietic and lymphoid	AML193	9.8
Haematopoietic and lymphoid	AMO1	9.7
Haematopoietic and lymphoid	BCP1	9.3
Haematopoietic and lymphoid	BDCM	9
Haematopoietic and lymphoid	BL41	10.3
Haematopoietic and lymphoid	BL70	10.5
Haematopoietic and lymphoid	BV173	10.1
Haematopoietic and lymphoid	CA46	9.3
Haematopoietic and lymphoid	CI1	9.7
Haematopoietic and lymphoid	CMK115	11
Haematopoietic and lymphoid	CMK86	10.6
Haematopoietic and lymphoid	CMK	10.7
Haematopoietic and lymphoid	CMLT1	10.1
Haematopoietic and lymphoid	COLO775	9.8
Haematopoietic and lymphoid	DAUDI	9.5
Haematopoietic and lymphoid	DB	9.8
Haematopoietic and lymphoid	DEL	9.1
Haematopoietic and lymphoid	DND41	9.5
Haematopoietic and lymphoid	DOHH2	9.8
Haematopoietic and lymphoid	EB1	8.9
Haematopoietic and lymphoid	EB2	9.2
Haematopoietic and lymphoid	EHEB	8.8
Haematopoietic and lymphoid	EJM	9.5
Haematopoietic and lymphoid	EM2	10
Haematopoietic and lymphoid	EOL1	9.6
Haematopoietic and lymphoid	F36P	9.6
Haematopoietic and lymphoid	GA10	9.8
Haematopoietic and lymphoid	GDM1	10.6
Haematopoietic and lymphoid	GRANTA519	8.9
Haematopoietic and lymphoid	HDLM2	9.1
Haematopoietic and lymphoid	HDMYZ	9.4
Haematopoietic and lymphoid	HEL9217	10.5
Haematopoietic and lymphoid	HEL	10.5
Haematopoietic and lymphoid	HH	9.1
Haematopoietic and lymphoid	HL60	10.5
Haematopoietic and lymphoid	HPBALL	9.7
Haematopoietic and lymphoid	HS604T	8.2
Haematopoietic and lymphoid	HS611T	9.4
Haematopoietic and lymphoid	HS616T	7.9
Haematopoietic and lymphoid	HS751T	8.1
Haematopoietic and lymphoid	HT	9
Haematopoietic and lymphoid	HTK	8.2
Haematopoietic and lymphoid	HUNS1	8.8
Haematopoietic and lymphoid	HUT102	9.6
Haematopoietic and lymphoid	HUT78	10
Haematopoietic and lymphoid	JEKO1	8.7
Haematopoietic and lymphoid	JK1	11.4
Haematopoietic and lymphoid	JM1	10.4
Haematopoietic and lymphoid	JURKAT	9.4
Haematopoietic and lymphoid	JURLMK1	10.1
Haematopoietic and lymphoid	JVM2	9.6
Haematopoietic and lymphoid	JVM3	9.4
Haematopoietic and lymphoid	K562	10.7
Haematopoietic and lymphoid	KARPAS299	8.2
Haematopoietic and lymphoid	KARPAS422	9.1
Haematopoietic and lymphoid	KARPAS620	10.1
Haematopoietic and lymphoid	KASUMI1	11.4
Haematopoietic and lymphoid	KASUMI2	10.4
Haematopoietic and lymphoid	KASUMI6	10.5
Haematopoietic and lymphoid	KCL22	9.6
Haematopoietic and lymphoid	KE37	10.3
Haematopoietic and lymphoid	KE97	9.5
Haematopoietic and lymphoid	KG1	9.5
Haematopoietic and lymphoid	KHM1B	10.1
Haematopoietic and lymphoid	KIJK	9.4
Haematopoietic and lymphoid	KMH2	10.5
Haematopoietic and lymphoid	KMM1	10
Haematopoietic and lymphoid	KMS11	10.2
Haematopoietic and lymphoid	KMS12BM	10.7
Haematopoietic and lymphoid	KMS18	9.6
Haematopoietic and lymphoid	KMS20	9.9
Haematopoietic and lymphoid	KMS21BM	9.4
Haematopoietic and lymphoid	KMS26	9.2
Haematopoietic and lymphoid	KMS27	9.1
Haematopoietic and lymphoid	KMS28BM	10.5
Haematopoietic and lymphoid	KMS34	10.3
Haematopoietic and lymphoid	KO52	9.5
Haematopoietic and lymphoid	KOPN8	9.3
Haematopoietic and lymphoid	KU812	10.4
Haematopoietic and lymphoid	KYO1	10.1
Haematopoietic and lymphoid	L1236	9.2
Haematopoietic and lymphoid	L363	9.4
Haematopoietic and lymphoid	L428	9.8
Haematopoietic and lymphoid	L540	9.5
Haematopoietic and lymphoid	LAMA84	9.2
Haematopoietic and lymphoid	LOUCY	10.5
Haematopoietic and lymphoid	LP1	9.6
Haematopoietic and lymphoid	M07E	11.7
Haematopoietic and lymphoid	MC116	9
Haematopoietic and lymphoid	ME1	10.6
Haematopoietic and lymphoid	MEC1	9
Haematopoietic and lymphoid	MEC2	8.8
Haematopoietic and lymphoid	MEG01	9.9
Haematopoietic and lymphoid	MHHCALL2	9.8
Haematopoietic and lymphoid	MHHCALL3	10
Haematopoietic and lymphoid	MHHCALL4	9.8
Haematopoietic and lymphoid	MINO	10.1
Haematopoietic and lymphoid	MJ	9.4
Haematopoietic and lymphoid	MM1S	9.9
Haematopoietic and lymphoid	MOLM13	9.4
Haematopoietic and lymphoid	MOLM16	10.6
Haematopoietic and lymphoid	MOLM6	10.3
Haematopoietic and lymphoid	MOLP2	9.1
Haematopoietic and lymphoid	MOLP8	8.9
Haematopoietic and lymphoid	MOLT13	10.5
Haematopoietic and lymphoid	MOLT16	10.5
Haematopoietic and lymphoid	MOLT4	10.7
Haematopoietic and lymphoid	MONOMAC1	10.7
Haematopoietic and lymphoid	MONOMAC6	10.2
Haematopoietic and lymphoid	MOTN1	8.5
Haematopoietic and lymphoid	MUTZ5	10
Haematopoietic and lymphoid	MV411	10.1
Haematopoietic and lymphoid	NALM19	10
Haematopoietic and lymphoid	NALM1	10.2
Haematopoietic and lymphoid	NALM6	9.9
Haematopoietic and lymphoid	NAMALWA	9.7
Haematopoietic and lymphoid	NB4	10.6
Haematopoietic and lymphoid	NCIH929	8.4
Haematopoietic and lymphoid	NCO2	10.9
Haematopoietic and lymphoid	NOMO1	10.1
Haematopoietic and lymphoid	NUDHL1	8.9
Haematopoietic and lymphoid	NUDUL1	9.8
Haematopoietic and lymphoid	OCIAML2	10.2
Haematopoietic and lymphoid	OCIAML3	10
Haematopoietic and lymphoid	OCIAML5	10
Haematopoietic and lymphoid	OCILY10	9.8
Haematopoietic and lymphoid	OCILY19	10.1
Haematopoietic and lymphoid	OCILY3	9.6
Haematopoietic and lymphoid	OCIM1	9.7
Haematopoietic and lymphoid	OPM2	10
Haematopoietic and lymphoid	P12ICHIKAWA	10.3
Haematopoietic and lymphoid	P31FUJ	10.5
Haematopoietic and lymphoid	P3HR1	9.8
Haematopoietic and lymphoid	PCM6	10
Haematopoietic and lymphoid	PEER	11.2
Haematopoietic and lymphoid	PF382	10.7
Haematopoietic and lymphoid	PFEIFFER	9.4
Haematopoietic and lymphoid	PL21	9.7
Haematopoietic and lymphoid	RAJI	9.8
Haematopoietic and lymphoid	RCHACV	10.2
Haematopoietic and lymphoid	REC1	9.7
Haematopoietic and lymphoid	REH	11
Haematopoietic and lymphoid	RI1	10.1
Haematopoietic and lymphoid	RL	9.8
Haematopoietic and lymphoid	RPMI8226	9.5
Haematopoietic and lymphoid	RPMI8402	10
Haematopoietic and lymphoid	RS411	10.5
Haematopoietic and lymphoid	SEM	10.1
Haematopoietic and lymphoid	SET2	9.4
Haematopoietic and lymphoid	SIGM5	10.1
Haematopoietic and lymphoid	SKM1	9.9
Haematopoietic and lymphoid	SKMM2	9.5
Haematopoietic and lymphoid	SR786	8.8
Haematopoietic and lymphoid	ST486	10.6
Haematopoietic and lymphoid	SUDHL10	9.4
Haematopoietic and lymphoid	SUDHL1	8.4
Haematopoietic and lymphoid	SUDHL4	9.1
Haematopoietic and lymphoid	SUDHL5	9.4
Haematopoietic and lymphoid	SUDHL6	9.5
Haematopoietic and lymphoid	SUDHL8	10.1
Haematopoietic and lymphoid	SUPB15	10
Haematopoietic and lymphoid	SUPHD1	8.8
Haematopoietic and lymphoid	SUPM2	9.2
Haematopoietic and lymphoid	SUPT11	10.3
Haematopoietic and lymphoid	SUPT1	10.7
Haematopoietic and lymphoid	TALL1	10.4
Haematopoietic and lymphoid	TF1	10.9
Haematopoietic and lymphoid	THP1	10.3
Haematopoietic and lymphoid	TO175T	8
Haematopoietic and lymphoid	TOLEDO	10.8
Haematopoietic and lymphoid	U266B1	9.8
Haematopoietic and lymphoid	U937	10.4
Haematopoietic and lymphoid	UT7	10.6
Haematopoietic and lymphoid	WSUDLCL2	8.9
Kidney	769P	9.4
Kidney	786O	9.6
Kidney	A498	9
Kidney	A704	8.9
Kidney	ACHN	8.7
Kidney	BFTC909	9.4
Kidney	CAKI1	9.3
Kidney	CAKI2	8.8
Kidney	CAL54	9.5
Kidney	KMRC1	9.1
Kidney	KMRC20	10.5
Kidney	KMRC2	9.6
Kidney	KMRC3	8.6
Kidney	OSRC2	9.8
Kidney	RCC10RGB	9.1
Kidney	SNU1272	9.6
Kidney	SNU349	7.9
Kidney	TUHR10TKB	9.4
Kidney	TUHR14TKB	9.4
Kidney	TUHR4TKB	9.3
Kidney	VMRCRCW	8.8
Kidney	VMRCRCZ	9.2
Large intestine	C2BBE1	10.4
Large intestine	CCK81	10.8
Large intestine	CL11	9.6
Large intestine	CL14	9.6
Large intestine	CL34	9.6
Large intestine	CL40	8.9
Large intestine	COLO205	9.9
Large intestine	COLO320	9.9
Large intestine	COLO678	10.4
Large intestine	CW2	10.1
Large intestine	DLD1	9.5
Large intestine	GP2D	11.1
Large intestine	HCC56	10.2
Large intestine	HCT116	8.7
Large intestine	HCT15	9.9
Large intestine	HS675T	7.9
Large intestine	HS698T	7.9
Large intestine	HT115	9.3
Large intestine	HT29	9.5
Large intestine	HT55	10
Large intestine	KM12	8
Large intestine	LOVO	9.4
Large intestine	LS1034	9.2
Large intestine	LS123	9.2
Large intestine	LS180	9.2
Large intestine	LS411N	11
Large intestine	LS513	10.3
Large intestine	MDST8	9.1
Large intestine	NCIH508	10.5
Large intestine	NCIH716	10.3
Large intestine	NCIH747	9.5
Large intestine	OUMS23	11.3
Large intestine	RCM1	9.7
Large intestine	RKO	8.3
Large intestine	SKCO1	10.3
Large intestine	SNU1040	8.1
Large intestine	SNU1197	8.7
Large intestine	SNU175	10.1
Large intestine	SNU283	10.2
Large intestine	SNU407	10.1
Large intestine	SNU503	9.7
Large intestine	SNU61	10
Large intestine	SNU81	8.7
Large intestine	SNUC1	10.9
Large intestine	SNUC2A	8.7
Large intestine	SNUC4	10.5
Large intestine	SNUC5	8.4
Large intestine	SW1116	9.3
Large intestine	SW1417	10.4
Large intestine	SW1463	9.4
Large intestine	SW403	10.2
Large intestine	SW480	9.3
Large intestine	SW48	9.9
Large intestine	SW620	10.2
Large intestine	SW837	9.4
Large intestine	SW948	10.9
Large intestine	T84	9.3
Liver	ALEXANDERCELLS	11.1
Liver	C3A	10.9
Liver	HEP3B217	11
Liver	HEPG2	11.7
Liver	HLE	7.8
Liver	HLF	8.1
Liver	HUH1	10.8
Liver	HUH6	10.1
Liver	HUH7	11.6
Liver	JHH1	9.7
Liver	JHH2	10.3
Liver	JHH4	10.5
Liver	JHH5	10.7
Liver	JHH6	9.4
Liver	JHH7	10
Liver	LI7	8.8
Liver	PLCPRF5	10.4
Liver	SKHEP1	9.5
Liver	SNU182	9.6
Liver	SNU387	9
Liver	SNU398	9.9
Liver	SNU423	9
Liver	SNU449	10.1
Liver	SNU475	8.5
Liver	SNU761	10.3
Liver	SNU878	10.6
Liver	SNU886	9.4
Lung	A549	8.5
Lung	ABC1	10.1
Lung	BEN	8.3
Lung	CAL12T	9.2
Lung	CALU1	8.4
Lung	CALU3	9.1
Lung	CALU6	9.2
Lung	CHAGOK1	10.1
Lung	COLO668	9.9
Lung	COLO699	9.2
Lung	CORL105	10.2
Lung	CORL23	8.9
Lung	CORL24	10.9
Lung	CORL279	9.5
Lung	CORL311	10.8
Lung	CORL47	10.5
Lung	CORL51	10.9
Lung	CORL88	10.6
Lung	CORL95	10.3
Lung	CPCN	9.9
Lung	DMS114	9.8
Lung	DMS153	10.5
Lung	DMS273	9.6
Lung	DMS454	10.5
Lung	DMS53	10.2
Lung	DMS79	10.8
Lung	DV90	9.1
Lung	EBC1	9.2
Lung	EPLC272H	8
Lung	HARA	8.9
Lung	HCC1171	9.5
Lung	HCC1195	9.7
Lung	HCC15	9.7
Lung	HCC2279	8.3
Lung	HCC2935	10.2
Lung	HCC33	10.4
Lung	HCC366	9.3
Lung	HCC4006	8.9
Lung	HCC44	9.2
Lung	HCC78	8.5
Lung	HCC827	8.6
Lung	HCC95	9.5
Lung	HLC1	9.5
Lung	HLFA	8.6
Lung	HS229T	8.9
Lung	HS618T	8.7
Lung	IALM	9.3
Lung	KNS62	7.2
Lung	LC1F	9.9
Lung	LC1SQSF	10.2
Lung	LCLC103H	8.9
Lung	LCLC97TM1	8.2
Lung	LK2	9.8
Lung	LOUNH91	9.2
Lung	LU65	9.8
Lung	LU99	8.2
Lung	LUDLU1	9.3
Lung	LXF289	8.8
Lung	MORCPR	8.8
Lung	NCIH1048	10.3
Lung	NCIH1092	11.4
Lung	NCIH1105	11.3
Lung	NCIH1155	10.1
Lung	NCIH1184	11.2
Lung	NCIH1299	8.9
Lung	NCIH1339	8.2
Lung	NCIH1341	9.7
Lung	NCIH1355	8
Lung	NCIH1373	8.8
Lung	NCIH1385	9.9
Lung	NCIH1395	8.9
Lung	NCIH1435	9.5
Lung	NCIH1436	10.7
Lung	NCIH1437	8.7
Lung	NCIH146	10.2
Lung	NCIH1563	7.7
Lung	NCIH1568	9.9
Lung	NCIH1573	7.9
Lung	NCIH1581	10
Lung	NCIH1618	10.6
Lung	NCIH1623	8.3
Lung	NCIH1648	9.4
Lung	NCIH1650	9.2
Lung	NCIH1651	10.3
Lung	NCIH1666	9.7
Lung	NCIH1693	8.9
Lung	NCIH1694	11.2
Lung	NCIH1703	8.9
Lung	NCIH1734	10.4
Lung	NCIH1755	10.4
Lung	NCIH1781	10.4
Lung	NCIH1792	8.7
Lung	NCIH1793	8.6
Lung	NCIH1836	10.4
Lung	NCIH1838	9.4
Lung	NCIH1869	8.9
Lung	NCIH1876	10.6
Lung	NCIH1915	8.5
Lung	NCIH1930	11
Lung	NCIH1944	8.2
Lung	NCIH1963	10.5
Lung	NCIH196	8.9
Lung	NCIH1975	10.5
Lung	NCIH2009	10
Lung	NCIH2023	8.7
Lung	NCIH2029	10.7
Lung	NCIH2030	8.5
Lung	NCIH2066	10.4
Lung	NCIH2081	10.7
Lung	NCIH2085	10.6
Lung	NCIH2087	9.4
Lung	NCIH209	10.5
Lung	NCIH2106	10.9
Lung	NCIH2110	9.5
Lung	NCIH211	11.1
Lung	NCIH2122	8.3
Lung	NCIH2126	9.1
Lung	NCIH2141	10.8
Lung	NCIH2170	9.6
Lung	NCIH2171	10
Lung	NCIH2172	9.5
Lung	NCIH2196	9.2
Lung	NCIH2227	10.1
Lung	NCIH2228	8.4
Lung	NCIH226	9.3
Lung	NCIH2286	8.9
Lung	NCIH2291	9.7
Lung	NCIH2342	11.3
Lung	NCIH2347	9.1
Lung	NCIH23	9
Lung	NCIH2405	8.9
Lung	NCIH2444	9.2
Lung	NCIH292	8
Lung	NCIH322	7.7
Lung	NCIH3255	10.4
Lung	NCIH358	10
Lung	NCIH441	9.3
Lung	NCIH446	10
Lung	NCIH460	9.2
Lung	NCIH510	9.8
Lung	NCIH520	9.5
Lung	NCIH522	9.5
Lung	NCIH524	9.8
Lung	NCIH526	10.3
Lung	NCIH596	8.5
Lung	NCIH647	9.2
Lung	NCIH650	9
Lung	NCIH661	9.6
Lung	NCIH69	10.9
Lung	NCIH727	9.6
Lung	NCIH810	9.6
Lung	NCIH82	9.9
Lung	NCIH838	9.2
Lung	NCIH841	9.7
Lung	NCIH854	8.8
Lung	NCIH889	10.5
Lung	PC14	9.2
Lung	RERFLCAD1	9
Lung	RERFLCAD2	8.2
Lung	RERFLCAI	9.3
Lung	RERFLCKJ	9.3
Lung	RERFLCMS	9.2
Lung	RERFLCSQ1	8.8
Lung	SBC5	9.6
Lung	SCLC21H	10.5
Lung	SHP77	10.8
Lung	SKLU1	8.9
Lung	SKMES1	8.1
Lung	SQ1	8.1
Lung	SW1271	8.8
Lung	SW1573	10.1
Lung	SW900	8.8
Lung	VMRCLCD	9.7
Lung	VMRCLCP	9.5
Oesophagus	COLO680N	8.3
Oesophagus	ECGI10	7.6
Oesophagus	KYSE140	8.8
Oesophagus	KYSE150	8.7
Oesophagus	KYSE180	8.5
Oesophagus	KYSE270	8.4
Oesophagus	KYSE30	8.1
Oesophagus	KYSE410	9.4
Oesophagus	KYSE450	9.2
Oesophagus	KYSE510	7.9
Oesophagus	KYSE520	7.7
Oesophagus	KYSE70	9.8
Oesophagus	OE19	10.9
Oesophagus	OE33	9.3
Oesophagus	TE10	9.8
Oesophagus	TE11	8.4
Oesophagus	TE14	7.6
Oesophagus	TE15	8.3
Oesophagus	TE1	9.3
Oesophagus	TE4	8.9
Oesophagus	TE5	8.7
Oesophagus	TE6	9.6
Oesophagus	TE8	9.5
Oesophagus	TE9	7.8
Oesophagus	TT	8.2
Ovary	59M	8
Ovary	A2780	9.7
Ovary	CAOV3	9.2
Ovary	CAOV4	10
Ovary	COLO704	11
Ovary	COV318	9.8
Ovary	COV362	10
Ovary	COV434	9.2
Ovary	COV504	8.1
Ovary	COV644	8.4
Ovary	EFO21	9.3
Ovary	EFO27	8.2
Ovary	ES2	9.2
Ovary	FUOV1	10.2
Ovary	HEYA8	7.7
Ovary	HS571T	7.3
Ovary	IGROV1	9.3
Ovary	JHOC5	8.5
Ovary	JHOM1	9.5
Ovary	JHOM2B	9.4
Ovary	JHOS2	9.2
Ovary	JHOS4	9.1
Ovary	KURAMOCHI	9.1
Ovary	MCAS	7.8
Ovary	NIHOVCAR3	8.5
Ovary	OAW28	9.9
Ovary	OAW42	9.4
Ovary	OC314	9.5
Ovary	OC316	9.7
Ovary	ONCODG1	9.3
Ovary	OV56	9.2
Ovary	OV7	8.7
Ovary	OV90	11
Ovary	OVCAR4	10.1
Ovary	OVCAR8	9.4
Ovary	OVISE	8
Ovary	OVK18	9.8
Ovary	OVKATE	9.9
Ovary	OVMANA	7.5
Ovary	OVSAHO	9.7
Ovary	OVTOKO	8.6
Ovary	RMGI	8.2
Ovary	RMUGS	7.9
Ovary	SKOV3	8
Ovary	SNU119	8.7
Ovary	SNU840	8.4
Ovary	SNU8	9.4
Ovary	TOV112D	8.6
Ovary	TOV21G	9.2
Ovary	TYKNU	9.4
Pancreas	ASPC1	8
Pancreas	BXPC3	8.2
Pancreas	CAPAN1	8.7
Pancreas	CAPAN2	8.9
Pancreas	CFPAC1	8.4
Pancreas	DANG	9.1
Pancreas	HPAC	8
Pancreas	HPAFII	7.2
Pancreas	HS766T	8.2
Pancreas	HUPT3	8.8
Pancreas	HUPT4	9.5
Pancreas	KCIMOH1	8.3
Pancreas	KLM1	8.2
Pancreas	KP2	9.6
Pancreas	KP3	8.3
Pancreas	KP4	9.2
Pancreas	L33	7.2
Pancreas	MIAPACA2	9.6
Pancreas	PANC0203	8
Pancreas	PANC0213	8.9
Pancreas	PANC0327	8.7
Pancreas	PANC0403	9.3
Pancreas	PANC0504	8.6
Pancreas	PANC0813	8.6
Pancreas	PANC1005	8.8
Pancreas	PANC1	9.6
Pancreas	PATU8902	8.3
Pancreas	PATU8988S	10.1
Pancreas	PATU8988T	9
Pancreas	PK1	9
Pancreas	PK45H	9.6
Pancreas	PK59	8.6
Pancreas	PL45	9.2
Pancreas	PSN1	8.5
Pancreas	QGP1	10.2
Pancreas	SNU213	8.9
Pancreas	SNU324	9.9
Pancreas	SNU410	9.8
Pancreas	SU8686	8.5
Pancreas	SUIT2	9.1
Pancreas	SW1990	9.3
Pancreas	T3M4	8
Pancreas	TCCPAN2	8.6
Pancreas	YAPC	9.6
Pleura	ACCMESO1	10.1
Pleura	DM3	7.6
Pleura	ISTMES1	9.2
Pleura	ISTMES2	9.8
Pleura	JL1	11
Pleura	MPP89	10
Pleura	MSTO211H	8.5
Pleura	NCIH2052	7.7
Pleura	NCIH2452	10
Pleura	NCIH28	9.2
Prostate	22RV1	10.3
Prostate	DU145	8.9
Prostate	LNCAPCLONEFGC	9.8
Prostate	MDAPCA2B	10
Prostate	NCIH660	9.9
Prostate	PC3	8.3
Prostate	VCAP	10.1
Salivary gland	A253	8.6
Salivary gland	YD15	8.6
Skin	A101D	10.7
Skin	A2058	8.9
Skin	A375	8.9
Skin	C32	10.6
Skin	CHL1	9.8
Skin	CJM	7.6
Skin	COLO679	10.3
Skin	COLO741	9.1
Skin	COLO783	9.3
Skin	COLO792	8.3
Skin	COLO800	8.9
Skin	COLO818	8.7
Skin	COLO829	9.4
Skin	COLO849	9.7
Skin	G361	9.2
Skin	GRM	9.8
Skin	HMCB	10.6
Skin	HS294T	9.4
Skin	HS600T	7.5
Skin	HS688AT	8
Skin	HS695T	10
Skin	HS839T	8.1
Skin	HS852T	9.2
Skin	HS895T	7.6
Skin	HS934T	8.1
Skin	HS936T	9.5
Skin	HS939T	9.6
Skin	HS940T	8
Skin	HS944T	8.7
Skin	HT144	9.7
Skin	IGR1	9.6
Skin	IGR37	8.6
Skin	IGR39	8.9
Skin	IPC298	9
Skin	K029AX	9.2
Skin	LOXIMVI	8.2
Skin	MALME3M	9.8
Skin	MDAMB435S	9
Skin	MELHO	9
Skin	MELJUSO	9.4
Skin	MEWO	8.6
Skin	RPMI7951	9.5
Skin	RVH421	9.4
Skin	SH4	9.5
Skin	SKMEL1	9.9
Skin	SKMEL24	9.7
Skin	SKMEL28	8.7
Skin	SKMEL2	10.1
Skin	SKMEL30	9
Skin	SKMEL31	9.6
Skin	SKMEL3	9.2
Skin	SKMEL5	8.6
Skin	UACC257	8.5
Skin	UACC62	10.1
Skin	WM115	9.1
Skin	WM1799	9.3
Skin	WM2664	8.8
Skin	WM793	9.2
Skin	WM88	9.6
Skin	WM983B	9.7
Small intestine	HUTU80	9.6
Soft tissue	A204	9.4
Soft tissue	G401	9.3
Soft tissue	G402	9.2
Soft tissue	GCT	8.7
Soft tissue	HS729	9.5
Soft tissue	HT1080	9.6
Soft tissue	KYM1	11
Soft tissue	MESSA	9.9
Soft tissue	RD	9.3
Soft tissue	RH30	8.4
Soft tissue	RH41	9.2
Soft tissue	RKN	8.7
Soft tissue	S117	8.1
Soft tissue	SJRH30	9.7
Soft tissue	SKLMS1	9.5
Soft tissue	SKUT1	10
Soft tissue	TE125T	7.3
Soft tissue	TE159T	7.6
Soft tissue	TE441T	10.7
Soft tissue	TE617T	9.4
Stomach	2313287	8.2
Stomach	AGS	11.1
Stomach	AZ521	9.5
Stomach	ECC10	10
Stomach	ECC12	10.4
Stomach	FU97	10.5
Stomach	GCIY	9.6
Stomach	GSS	9.3
Stomach	GSU	11.2
Stomach	HGC27	9.7
Stomach	HS746T	9.5
Stomach	HUG1N	10.9
Stomach	IM95	11.3
Stomach	KATOIII	10.1
Stomach	KE39	11.2
Stomach	LMSU	8.5
Stomach	MKN1	10
Stomach	MKN45	8.1
Stomach	MKN74	9.3
Stomach	MKN7	9.7
Stomach	NCCSTCK140	10.3
Stomach	NCIN87	7.8
Stomach	NUGC2	8.8
Stomach	NUGC3	8.9
Stomach	NUGC4	10.2
Stomach	OCUM1	9.9
Stomach	RERFGC1B	10.2
Stomach	SH10TC	9.4
Stomach	SNU16	9.5
Stomach	SNU1	10.6
Stomach	SNU216	9.1
Stomach	SNU520	11.6
Stomach	SNU5	8.7
Stomach	SNU601	10
Stomach	SNU620	13.1
Stomach	SNU668	7.7
Stomach	SNU719	10
Stomach	TGBC11TKB	9.3
Thyroid	8305C	9.2
Thyroid	8505C	8.4
Thyroid	BCPAP	8.5
Thyroid	BHT101	9.1
Thyroid	CAL62	9
Thyroid	CGTHW1	9
Thyroid	FTC133	10.5
Thyroid	FTC238	9.4
Thyroid	ML1	9.6
Thyroid	SW579	8.3
Thyroid	TT2609C02	9.6
Thyroid	TT	9.8
Upper aerodigestive tract	BHY	8.1
Upper aerodigestive tract	BICR16	8.5
Upper aerodigestive tract	BICR18	8.2
Upper aerodigestive tract	BICR22	7.8
Upper aerodigestive tract	BICR31	8.6
Upper aerodigestive tract	BICR56	8.4
Upper aerodigestive tract	BICR6	8.6
Upper aerodigestive tract	CAL27	8.1
Upper aerodigestive tract	CAL33	7.9
Upper aerodigestive tract	DETROIT562	7.7
Upper aerodigestive tract	FADU	8.6
Upper aerodigestive tract	HS840T	8.5
Upper aerodigestive tract	HSC2	7.9
Upper aerodigestive tract	HSC3	7.5
Upper aerodigestive tract	HSC4	9.1
Upper aerodigestive tract	PECAPJ15	8.2
Upper aerodigestive tract	PECAPJ34CLONEC12	6.9
Upper aerodigestive tract	PECAPJ41CLONED2	8.2
Upper aerodigestive tract	PECAPJ49	7.7
Upper aerodigestive tract	SCC15	7.9
Upper aerodigestive tract	SCC25	7.8
Upper aerodigestive tract	SCC4	7.5
Upper aerodigestive tract	SCC9	7.5
Upper aerodigestive tract	SNU1076	8.6
Upper aerodigestive tract	SNU1214	8.8
Upper aerodigestive tract	SNU46	9
Upper aerodigestive tract	SNU899	8.7
Upper aerodigestive tract	YD10B	8
Upper aerodigestive tract	YD38	7.8
Upper aerodigestive tract	YD8	7.9
Urinary tract	5637	8.7
Urinary tract	639V	9
Urinary tract	647V	9
Urinary tract	BC3C	8
Urinary tract	BFTC905	8.7
Urinary tract	CAL29	9.7
Urinary tract	HS172T	7.3
Urinary tract	HT1197	9.9
Urinary tract	HT1376	9.9
Urinary tract	J82	8.5
Urinary tract	JMSU1	9
Urinary tract	KMBC2	9.9
Urinary tract	KU1919	9.2
Urinary tract	RT11284	9.7
Urinary tract	RT112	9.2
Urinary tract	RT4	10.1
Urinary tract	SCABER	7.8
Urinary tract	SW1710	9.7
Urinary tract	SW780	9.7
Urinary tract	T24	8.3
Urinary tract	TCCSUP	8.7
Urinary tract	UMUC1	8.8
Urinary tract	UMUC3	9.4
Urinary tract	VMCUB1	7.6

> The Human Protein Atlas (HPA)

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Tissue	Expression Level (TPM)
Adipose tissue	7.6
Adrenal gland	20.1
Appendix	9.5
Bone marrow	6.9
Breast	11.3
Cerebral cortex	17.7
Cervix, uterine	9.8
Colon	8.2
Duodenum	10.4
Endometrium	14.7
Epididymis	10.1
Esophagus	9.4
Fallopian tube	9.5
Gallbladder	8.6
Heart muscle	7
Kidney	8.7
Liver	11.9
Lung	17.2
Lymph node	9.4
Ovary	37.2
Pancreas	2.3
Parathyroid gland	33.3
Placenta	17.4
Prostate	18.8
Rectum	10.5
Salivary gland	3
Seminal vesicle	7.2
Skeletal muscle	3.8
Skin	10.2
Small intestine	10.9
Smooth muscle	11.5
Spleen	10.1
Stomach	10.8
Testis	49.5
Thyroid gland	15.2
Tonsil	7.4
Urinary bladder	9.7

> Text Mining based Expression

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PMID	Expression	Cancer	Evidence
27689360	underexpression	Esophageal Squamous Cell Carcinoma	Both mRNA and protein expression levels of TRIM24 were found to be significantly decreased in ESCC, as judged by qRT-PCR and western blot.
27238081	overexpression	Castration-Resistant Prostate Carcinoma	TRIM24 augments ARsignaling, and AR and TRIM24 co-activated genes are significantly upregulated in CRPC.
26805734	overexpression	Non-Small Cell Lung Carcinoma	Study found that TRIM24 was overexpressed in non-small cell lung cancer (NSCLC) tissues and regulate cell growth, cell cycle and apoptosis in lung cell lines.
25846736	overexpression	Bladder Carcinoma	We found that TRIM24 expression was upregulated in 39 of 95 (41.1 %) specimens compared with normal control.
25724180	overexpression	Gastric Carcinoma	TRIM24 upregulation positively correlated with clinical stage, local invasion, and poor patient prognosis.
25281858	overexpression	Hepatocellular Carcinoma	Aberrantly high expression of TRIM24 occurs in human cancers, including hepatocellular carcinoma.
24469053	aberrant expression	Malignant Glioma	We report here that TRIM24 expression is positively correlated with glioma malignancy and is negatively associated with prognosis of patients with newly diagnosed glioblastoma, which is the most malignant form of gliomas but displays highly heterogeneous clinical outcome.
24409330	overexpression	Hepatocellular Carcinoma	Elevated TRIM24 level was found in 61.4% HCC samples (51/83) correlating with AFP (P=0.036), poor differentiation (P=0.004), intrahepatic metastasis (P=0.004), recurrence (P=0.000006), and shorter tumor-free survival time (P=0.002).
23717505	overexpression	Head and Neck Squamous Cell Carcinoma	TRIM24 variants were up-regulated in 56 HNSCC samples (P<.001) and 9 HNSCC cell lines (P<.05).
22666376	overexpression	Non-Small Cell Lung Carcinoma	TRIM24 was found to be overexpressed in 81 of 113 (71.7%) human lung cancer samples and correlated with p-TNM stage (p = 0.0006), poor differentiation (p = 0.004), Ki67 index (p<0.0001), cyclin D1(p = 0.0096) and p-Rb expression (p = 0.0318).
28454326	Overexpression	Gastric Carcinoma	In the present study, it was found that TRIM24 was frequently overexpressed in GC cell lines and tissues compared with normal controls, as determined by western blotting and immunohistochemical staining. The high nuclear expression of TRIM24 was correlated with the depth of invasion (P=0.007), tumor-node-metastasis stage (P=0.005), and lymph node metastasis (P=0.027), and shorter overall survival rates (P=0.010) in patients with GC.
28337289	Overexpression	Cervical Carcinoma	In the present study, we showed that the expression of TRIM24 was markedly upregulated in cervical cancer cell lines and cancerous specimens at both transcriptional and translational levels. Statistical analysis suggested that TRIM24 expression was significantly correlated with clinical stage and (P=0.007) and lymphatic metastasis (P=0.001).
27638829	Overexpression	Breast Carcinoma	Our results demonstrated that TRIM24 expression is positively correlated with H3K23ac levels, and high levels of both TRIM24 and H3K23ac predict shorter overall survival of breast cancer patients.

Summary
Symbol	TRIM24
Name	tripartite motif containing 24
Aliases	hTIF1; Tif1a; RNF82; TIF1; transcriptional intermediary factor 1; tripartite motif-containing 24; PTC6; TF1A ......
Location	7q33-q34
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

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Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.327	1.62e-11	10.9	55.9	33.2	Neutral
BRCA	Breast invasive carcinoma	1075	0.439	6.96e-52	13.6	59.2	27.3	Neutral
CESC	Cervical and endocervical cancers	292	0.464	5.18e-17	19.2	68.2	12.7	Neutral
COAD	Colon adenocarcinoma	449	0.373	2.64e-16	1.1	49.4	49.4	Gain
ESCA	Esophageal carcinoma	183	0.415	5.18e-09	32.8	37.2	30.1	Neutral
GBM	Glioblastoma multiforme	147	0.469	2.03e-09	0	16.3	83.7	Gain
HNSC	Head and Neck squamous cell carcinoma	514	0.432	7.81e-25	23	59.1	17.9	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.408	1.67e-22	1.3	66.5	32.2	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.363	2.08e-10	0.3	38.9	60.8	Gain
LAML	Acute Myeloid Leukemia	166	0.343	6.05e-06	11.4	88.6	0	Neutral
LGG	Brain Lower Grade Glioma	513	0.411	2.49e-22	0.8	64.9	34.3	Gain
LIHC	Liver hepatocellular carcinoma	364	0.289	1.87e-08	8.8	59.9	31.3	Neutral
LUAD	Lung adenocarcinoma	512	0.379	5.92e-19	10.4	47.9	41.8	Gain
LUSC	Lung squamous cell carcinoma	498	0.483	1.69e-30	17.3	40.4	42.4	Gain
OV	Ovarian serous cystadenocarcinoma	300	0.556	9.31e-26	12.7	38.7	48.7	Gain
PAAD	Pancreatic adenocarcinoma	177	0.277	0.000189	9	68.4	22.6	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.182	0.0203	4.9	82.1	13	Neutral
PRAD	Prostate adenocarcinoma	491	0.397	5.19e-20	2	78.8	19.1	Neutral
READ	Rectum adenocarcinoma	164	0.309	5.53e-05	1.8	45.1	53	Gain
SARC	Sarcoma	255	0.387	1.52e-10	16.5	54.1	29.4	Neutral
SKCM	Skin Cutaneous Melanoma	367	0.512	6.33e-26	4.4	34.6	61	Gain
STAD	Stomach adenocarcinoma	413	0.4	2.5e-17	18.2	49.6	32.2	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.434	2.99e-08	8	30	62	Gain
THCA	Thyroid carcinoma	497	0.327	7.76e-14	0	96	4	Neutral
THYM	Thymoma	119	-0.015	0.867	2.5	83.2	14.3	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.405	1.41e-22	10.8	74.5	14.7	Neutral

Summary
Symbol	TRIM24
Name	tripartite motif containing 24
Aliases	hTIF1; Tif1a; RNF82; TIF1; transcriptional intermediary factor 1; tripartite motif-containing 24; PTC6; TF1A ......
Location	7q33-q34
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.104	0.0322	17	408	-0.018	0.0176	NS/NA
BRCA	Breast invasive carcinoma	-0.222	4.22e-11	83	785	0.001	0.00564	NS/NA
CESC	Cervical and endocervical cancers	-0.231	4.19e-05	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.155	0.00587	19	297	0	0.468	NS/NA
ESCA	Esophageal carcinoma	-0.176	0.0141	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.309	0.0126	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.296	2.69e-12	20	522	0.002	0.00371	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.037	0.49	24	319	-0.003	0.00334	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.168	0.00366	23	275	0.001	0.773	NS/NA
LAML	Acute Myeloid Leukemia	-0.127	0.0979	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.136	0.00173	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.15	0.00223	41	373	0	0.011	NS/NA
LUAD	Lung adenocarcinoma	-0.025	0.586	21	456	0.002	0.681	NS/NA
LUSC	Lung squamous cell carcinoma	-0.158	0.00214	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.567	0.121	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.006	0.936	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.171	0.0195	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.099	0.0217	35	498	0	0.593	NS/NA
READ	Rectum adenocarcinoma	-0.105	0.295	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.158	0.0106	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.32	1.53e-12	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.109	0.035	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.527	0	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.102	0.016	50	509	0	0.721	NS/NA
THYM	Thymoma	-0.133	0.145	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.125	0.00683	34	431	-0.001	0.0238	NS/NA

Summary
Symbol	TRIM24
Name	tripartite motif containing 24
Aliases	hTIF1; Tif1a; RNF82; TIF1; transcriptional intermediary factor 1; tripartite motif-containing 24; PTC6; TF1A ......
Location	7q33-q34
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	0	Not detected
Appendix	1	Low
Breast	1	Low
Bronchus	0	Not detected
Caudate	1	Low
Cerebellum	0	Not detected
Cerebral cortex	0	Not detected
Cervix, uterine	0	Not detected
Colon	2	Medium
Duodenum	2	Medium
Endometrium	1	Low
Epididymis	0	Not detected
Esophagus	2	Medium
Fallopian tube	1	Low
Gallbladder	1	Low
Heart muscle	0	Not detected
Hippocampus	0	Not detected
Kidney	0	Not detected
Liver	0	Not detected
Lung	1	Low
Lymph node	1	Low
Nasopharynx	2	Medium
Oral mucosa	2	Medium
Ovary	2	Medium
Pancreas	0	Not detected
Parathyroid gland	1	Low
Placenta	2	Medium
Prostate	1	Low
Rectum	2	Medium
Salivary gland	1	Low
Seminal vesicle	0	Not detected
Skeletal muscle	1	Low
Skin	1	Low
Small intestine	2	Medium
Smooth muscle	1	Low
Soft tissue	0	Not detected
Spleen	0	Not detected
Stomach	1	Low
Testis	2	Medium
Thyroid gland	3	High
Tonsil	1	Low
Urinary bladder	2	Medium
Vagina	2	Medium

Summary
Symbol	TRIM24
Name	tripartite motif containing 24
Aliases	hTIF1; Tif1a; RNF82; TIF1; transcriptional intermediary factor 1; tripartite motif-containing 24; PTC6; TF1A ......
Location	7q33-q34
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.045	Significant	24476821
BRCA	Breast invasive carcinoma	521	5.86e-07	Significant	23000897
COAD	Colon adenocarcinoma	149	0.000383	Significant	22810696
GBM	Glioblastoma multiforme	157	0.00245	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	9.78e-13	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.073	NS	26536169
LGG	Brain Lower Grade Glioma	513	0.00109	Significant	26824661
LUAD	Lung adenocarcinoma	230	0.66	NS	25079552
LUSC	Lung squamous cell carcinoma	178	5.6e-06	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.0211	Significant	21720365
PRAD	Prostate adenocarcinoma	333	2.9e-05	Significant	26544944
READ	Rectum adenocarcinoma	67	0.000238	Significant	22810696
SKCM	Skin Cutaneous Melanoma	315	8.35e-06	Significant	26091043
STAD	Stomach adenocarcinoma	277	1.3e-10	Significant	25079317
THCA	Thyroid carcinoma	391	3.56e-13	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.0566	NS	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	0.874	0.527	NS
BRCA	Breast invasive carcinoma	1079	1.036	0.874	NS
CESC	Cervical and endocervical cancers	291	0.855	0.6	NS
COAD	Colon adenocarcinoma	439	0.978	0.942	NS
ESCA	Esophageal carcinoma	184	0.658	0.19	NS
GBM	Glioblastoma multiforme	158	1.285	0.329	NS
HNSC	Head and Neck squamous cell carcinoma	518	0.795	0.231	NS
KIRC	Kidney renal clear cell carcinoma	531	0.705	0.1	NS
KIRP	Kidney renal papillary cell carcinoma	287	0.995	0.989	NS
LAML	Acute Myeloid Leukemia	149	0.385	0.00149	Longer
LGG	Brain Lower Grade Glioma	511	1.621	0.0452	Shorter
LIHC	Liver hepatocellular carcinoma	365	1.747	0.0272	Shorter
LUAD	Lung adenocarcinoma	502	0.699	0.0745	NS
LUSC	Lung squamous cell carcinoma	494	0.743	0.136	NS
OV	Ovarian serous cystadenocarcinoma	303	0.883	0.558	NS
PAAD	Pancreatic adenocarcinoma	177	1.336	0.353	NS
PCPG	Pheochromocytoma and Paraganglioma	179	0.71	0.706	NS
PRAD	Prostate adenocarcinoma	497	1.511	0.649	NS
READ	Rectum adenocarcinoma	159	0.805	0.7	NS
SARC	Sarcoma	259	0.936	0.816	NS
SKCM	Skin Cutaneous Melanoma	459	0.824	0.33	NS
STAD	Stomach adenocarcinoma	388	0.814	0.342	NS
TGCT	Testicular Germ Cell Tumors	134	0.435	0.484	NS
THCA	Thyroid carcinoma	500	2.45	0.18	NS
THYM	Thymoma	119	0	0.0813	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	0.944	0.859	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	0.032	0.523	NS
BRCA	Breast invasive carcinoma	1071	0.03	0.331	NS
CESC	Cervical and endocervical cancers	167	0.121	0.12	NS
COAD	Colon adenocarcinoma	445	0.048	0.314	NS
ESCA	Esophageal carcinoma	162	-0.004	0.956	NS
HNSC	Head and Neck squamous cell carcinoma	448	-0.031	0.509	NS
KIRC	Kidney renal clear cell carcinoma	531	-0.088	0.0431	Lower
KIRP	Kidney renal papillary cell carcinoma	260	0.057	0.357	NS
LIHC	Liver hepatocellular carcinoma	347	0.088	0.102	NS
LUAD	Lung adenocarcinoma	507	-0.054	0.229	NS
LUSC	Lung squamous cell carcinoma	497	0.036	0.425	NS
OV	Ovarian serous cystadenocarcinoma	302	0.041	0.482	NS
PAAD	Pancreatic adenocarcinoma	176	-0.031	0.684	NS
READ	Rectum adenocarcinoma	156	0.071	0.378	NS
SKCM	Skin Cutaneous Melanoma	410	0.031	0.535	NS
STAD	Stomach adenocarcinoma	392	0.009	0.853	NS
TGCT	Testicular Germ Cell Tumors	81	0.083	0.462	NS
THCA	Thyroid carcinoma	499	-0.055	0.222	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.024	0.585	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	-0.005	0.932	NS
HNSC	Head and Neck squamous cell carcinoma	498	0.049	0.279	NS
KIRC	Kidney renal clear cell carcinoma	525	-0.072	0.102	NS
LGG	Brain Lower Grade Glioma	514	0.17	0.000108	Higher
LIHC	Liver hepatocellular carcinoma	366	0.113	0.031	Higher
OV	Ovarian serous cystadenocarcinoma	296	-0.037	0.53	NS
PAAD	Pancreatic adenocarcinoma	176	-0.073	0.335	NS
STAD	Stomach adenocarcinoma	406	-0.197	6.49e-05	Lower
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.063	0.145	NS

Summary
Symbol	TRIM24
Name	tripartite motif containing 24
Aliases	hTIF1; Tif1a; RNF82; TIF1; transcriptional intermediary factor 1; tripartite motif-containing 24; PTC6; TF1A ......
Location	7q33-q34
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	TRIM24
Name	tripartite motif containing 24
Aliases	hTIF1; Tif1a; RNF82; TIF1; transcriptional intermediary factor 1; tripartite motif-containing 24; PTC6; TF1A ......
Location	7q33-q34
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for TRIM24.

Summary
Symbol	TRIM24
Name	tripartite motif containing 24
Aliases	hTIF1; Tif1a; RNF82; TIF1; transcriptional intermediary factor 1; tripartite motif-containing 24; PTC6; TF1A ......
Location	7q33-q34
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
26805734	Non-Small Cell Lung Carcinoma	partner	p-BAD; Bcl-2	positive correlation	Down-regulated of endogenous TRIM24 and ShTRIM24 with Gifitinib could also reduce the protein related apoptosis, such as p-BAD and Bcl-2, and the protein PIK3CA related AKT signal path in A549 cell.
25846736	Bladder Carcinoma	downstream	CCND1; CCNE1; p-IκBα; p-AKT	positive regulation	Western blot analysis demonstrated that TRIM24 upregulated cyclin D1, cyclin E, p-IκBα, and p-AKT expression, suggesting TRIM24 activates NF-κB and AKT pathways.
25724180	Gastric Carcinoma	downstream	CCND1; Akt	regulation	Further analysis showed that TRIM24 overexpression upregulated cyclin D1 and Akt phosphorylation.
24409330	Hepatocellular Carcinoma	downstream	p53; Bax; CASP8; Bcl-2; BIRC5; CCND1; CDK4	negative regulation; negative regulation; negative regulation; positive regulation; positive regulation; positive regulation; positive regulation	Moreover, western blotting analysis revealed that knockdown of TRIM24 increased the protein levels of p53, Bax, and Caspase-8, and decreased Bcl-2, Survivin, Cyclin D1, and CDK4.
24345920	Melanoma	partner	BRAF	Fusion	NGS data analysis of 51 additional melanomas revealed a second BRAF fusion (TRIM24-BRAF) in a pan-negative sample; MAPK signaling induced by TRIM24-BRAF was also MEK inhibitor sensitive.
22666376	Non-Small Cell Lung Carcinoma	downstream	CCNA1; CCNB1; CCND1; CCNE1; p-Rb; P27	positive regulation; positive regulation; positive regulation; positive regulation; positive regulation; negative regulation	Western blotting analysis revealed that knockdown of TRIM24 decreased the protein levels of Cyclin A, Cyclin B, Cyclin D1, cyclin E and p-Rb and increased P27 expression.
27638829	Breast Carcinoma	partner	H3K23ac	correlation	Our results demonstrated that TRIM24 expression is positively correlated with H3K23ac levels, and high levels of both TRIM24 and H3K23ac predict shorter overall survival of breast cancer patients.