CR2Cancer

Summary
Symbol	TRIM33
Name	tripartite motif containing 33
Aliases	TIF1GAMMA; FLJ11429; KIAA1113; TIFGAMMA; RFG7; TF1G; TIF1G; PTC7; transcriptional intermediary factor 1 gamm ......
Location	1p13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

[ TOP ]

Domain

PF00439 Bromodomain
PF00628 PHD-finger
PF00643 B-box zinc finger
PF13445 RING-type zinc-finger

Function

Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade).

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification read	#	H3K9me3, H3K18ac	#	23926104

> Gene Ontology [ TOP ]
Biological Process	GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007179 transforming growth factor beta receptor signaling pathway GO:0017015 regulation of transforming growth factor beta receptor signaling pathway GO:0030509 BMP signaling pathway GO:0030510 regulation of BMP signaling pathway GO:0030514 negative regulation of BMP signaling pathway GO:0071559 response to transforming growth factor beta GO:0071560 cellular response to transforming growth factor beta stimulus GO:0071772 response to BMP GO:0071773 cellular response to BMP stimulus GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway GO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway GO:0090287 regulation of cellular response to growth factor stimulus GO:0090288 negative regulation of cellular response to growth factor stimulus GO:1903844 regulation of cellular response to transforming growth factor beta stimulus
Molecular Function	GO:0004842 ubiquitin-protein transferase activity GO:0016874 ligase activity GO:0019787 ubiquitin-like protein transferase activity GO:0046332 SMAD binding GO:0070410 co-SMAD binding GO:0070412 R-SMAD binding
Cellular Component	-

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-2173795: Downregulation of SMAD2/3 R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-162582: Signal Transduction R-HSA-170834: Signaling by TGF-beta Receptor Complex R-HSA-2173793: Transcriptional activity of SMAD2/SMAD3

Summary
Symbol	TRIM33
Name	tripartite motif containing 33
Aliases	TIF1GAMMA; FLJ11429; KIAA1113; TIFGAMMA; RFG7; TF1G; TIF1G; PTC7; transcriptional intermediary factor 1 gamm ......
Location	1p13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM133957	c.815G>A	p.R272H	Substitution - Missense	Large_intestine
COSM3704850	c.2927A>G	p.H976R	Substitution - Missense	Liver
COSM4736038	c.2986delA	p.I996fs*2	Deletion - Frameshift	Large_intestine
COSM3704850	c.2927A>G	p.H976R	Substitution - Missense	Liver
COSM894168	c.3322G>T	p.D1108Y	Substitution - Missense	Endometrium
COSM35460	c.3169A>T	p.K1057*	Substitution - Nonsense	Central_nervous_system
COSM4020868	c.1337G>A	p.R446Q	Substitution - Missense	Stomach
COSM1491616	c.1635T>A	p.T545T	Substitution - coding silent	Kidney
COSM4736046	c.2389_2390insA	p.T797fs*15	Insertion - Frameshift	Large_intestine
COSM462671	c.1619C>A	p.P540Q	Substitution - Missense	Kidney
COSM4020863	c.1466A>T	p.N489I	Substitution - Missense	Stomach
COSM3934018	c.1786G>T	p.A596S	Substitution - Missense	Oesophagus
COSM4736042	c.2612C>T	p.S871L	Substitution - Missense	Large_intestine
COSM4886924	c.490C>A	p.P164T	Substitution - Missense	Upper_aerodigestive_tract
COSM20449	c.3039_3040insA	p.H1014fs*10	Insertion - Frameshift	Large_intestine
COSM4383184	c.1249A>T	p.N417Y	Substitution - Missense	Large_intestine
COSM894176	c.2818G>T	p.E940*	Substitution - Nonsense	Endometrium
COSM242036	c.3271G>C	p.E1091Q	Substitution - Missense	Prostate
COSM5562858	c.2129C>T	p.P710L	Substitution - Missense	Prostate
COSM5904131	c.2746C>T	p.P916S	Substitution - Missense	Skin
COSM3984112	c.1887C>G	p.P629P	Substitution - coding silent	Kidney
COSM4020858	c.1931G>A	p.S644N	Substitution - Missense	Stomach
COSM2157079	c.1319G>A	p.R440H	Substitution - Missense	Central_nervous_system
COSM1600583	c.2768+10A>G	p.?	Unknown	Liver
COSM674239	c.2412T>G	p.A804A	Substitution - coding silent	Lung
COSM5037362	c.1339T>A	p.C447S	Substitution - Missense	Oesophagus
COSM5458196	c.1213C>A	p.L405I	Substitution - Missense	Large_intestine
COSM392615	c.1650_1651insA	p.Q551fs*5	Insertion - Frameshift	Lung
COSM1685148	c.2802T>C	p.I934I	Substitution - coding silent	Lung
COSM2177209	c.1932C>T	p.S644S	Substitution - coding silent	Skin
COSM4020872	c.1005T>G	p.N335K	Substitution - Missense	Stomach
COSM5678351	c.432C>T	p.P144P	Substitution - coding silent	Soft_tissue
COSM140953	c.2155C>T	p.P719S	Substitution - Missense	Upper_aerodigestive_tract
COSM360693	c.1267G>T	p.G423C	Substitution - Missense	Lung
COSM4765928	c.200_201insG	p.A68fs*70	Insertion - Frameshift	Stomach
COSM5732173	c.1109T>C	p.I370T	Substitution - Missense	Pancreas
COSM5019221	c.1303-10delT	p.?	Unknown	Soft_tissue
COSM3750243	c.1146A>G	p.Q382Q	Substitution - coding silent	Soft_tissue
COSM3788465	c.3121A>G	p.M1041V	Substitution - Missense	Urinary_tract
COSM5045484	c.2738G>T	p.C913F	Substitution - Missense	Oesophagus
COSM3667314	c.3047A>T	p.Q1016L	Substitution - Missense	Liver
COSM1332873	c.2864C>T	p.A955V	Substitution - Missense	Large_intestine
COSM323983	c.2245G>T	p.G749C	Substitution - Missense	Lung
COSM1491616	c.1635T>A	p.T545T	Substitution - coding silent	Kidney
COSM4736057	c.1631C>A	p.P544Q	Substitution - Missense	Large_intestine
COSM3788468	c.949C>G	p.Q317E	Substitution - Missense	Urinary_tract
COSM4998182	c.1241A>C	p.N414T	Substitution - Missense	Pancreas
COSM3750243	c.1146A>G	p.Q382Q	Substitution - coding silent	Soft_tissue
COSM3740552	c.2689G>T	p.G897*	Substitution - Nonsense	Liver
COSM894184	c.1782G>C	p.Q594H	Substitution - Missense	Endometrium
COSM1559267	c.157G>C	p.A53P	Substitution - Missense	Central_nervous_system
COSM21194	c.3255C>T	p.T1085T	Substitution - coding silent	Skin
COSM894180	c.2399G>A	p.G800D	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM2177239	c.1421G>A	p.G474D	Substitution - Missense	Large_intestine
COSM894181	c.2081G>A	p.S694N	Substitution - Missense	Endometrium
COSM1626323	c.2127A>T	p.L709L	Substitution - coding silent	Liver
COSM5052409	c.1819G>A	p.G607S	Substitution - Missense	Stomach
COSM5724594	c.2406G>T	p.R802S	Substitution - Missense	Skin
COSM1230319	c.1318C>T	p.R440C	Substitution - Missense	Large_intestine
COSM285940	c.2593C>T	p.R865*	Substitution - Nonsense	Large_intestine
COSM3687035	c.1029G>A	p.Q343Q	Substitution - coding silent	Large_intestine
COSM3801349	c.3190C>T	p.Q1064*	Substitution - Nonsense	Breast
COSM894172	c.3016G>A	p.V1006M	Substitution - Missense	Endometrium
COSM13373	c.2653C>T	p.P885S	Substitution - Missense	Central_nervous_system
COSM5562858	c.2129C>T	p.P710L	Substitution - Missense	Prostate
COSM4639322	c.982G>T	p.A328S	Substitution - Missense	Large_intestine
COSM12939	c.2431G>A	p.E811K	Substitution - Missense	Lung
COSM894177	c.2816T>A	p.V939D	Substitution - Missense	Endometrium
COSM1600584	c.915A>G	p.K305K	Substitution - coding silent	Liver
COSM1559266	c.1887C>A	p.P629P	Substitution - coding silent	Central_nervous_system
COSM371222	c.760C>G	p.H254D	Substitution - Missense	Lung
COSM894186	c.1172G>T	p.R391I	Substitution - Missense	Endometrium
COSM1332878	c.1035G>A	p.Q345Q	Substitution - coding silent	Large_intestine
COSM1559267	c.157G>C	p.A53P	Substitution - Missense	Central_nervous_system
COSM1560085	c.2900A>G	p.E967G	Substitution - Missense	Large_intestine
COSM2177142	c.3258C>T	p.F1086F	Substitution - coding silent	Oesophagus
COSM894174	c.2903G>A	p.R968H	Substitution - Missense	Endometrium
COSM1600583	c.2768+10A>G	p.?	Unknown	Liver
COSM4610892	c.1650_1651insACA	p.T550_Q551insT	Insertion - In frame	Large_intestine
COSM3750243	c.1146A>G	p.Q382Q	Substitution - coding silent	Soft_tissue
COSM2177184	c.2579G>A	p.G860E	Substitution - Missense	Large_intestine
COSM3801351	c.2929G>T	p.E977*	Substitution - Nonsense	Breast
COSM4736044	c.2455_2456delTC	p.S819fs*8	Deletion - Frameshift	Large_intestine
COSM1491616	c.1635T>A	p.T545T	Substitution - coding silent	Kidney
COSM334171	c.2902C>G	p.R968G	Substitution - Missense	Lung
COSM894178	c.2710A>C	p.K904Q	Substitution - Missense	Endometrium
COSM1626324	c.2074G>T	p.G692C	Substitution - Missense	Liver
COSM5966210	c.2128C>T	p.P710S	Substitution - Missense	Adrenal_gland
COSM894182	c.2037G>A	p.S679S	Substitution - coding silent	Endometrium
COSM674237	c.1227G>A	p.V409V	Substitution - coding silent	Lung
COSM894187	c.1053A>G	p.V351V	Substitution - coding silent	Endometrium
COSM1559267	c.157G>C	p.A53P	Substitution - Missense	Central_nervous_system
COSM3750243	c.1146A>G	p.Q382Q	Substitution - coding silent	Soft_tissue
COSM5477504	c.1544G>A	p.R515Q	Substitution - Missense	Large_intestine
COSM5019221	c.1303-10delT	p.?	Unknown	Soft_tissue
COSM894169	c.3281A>G	p.Q1094R	Substitution - Missense	Endometrium
COSM3471570	c.3265T>C	p.L1089L	Substitution - coding silent	Skin
COSM5886111	c.1040+1G>A	p.?	Unknown	Skin
COSM2177186	c.2554T>A	p.S852T	Substitution - Missense	Large_intestine
COSM4565225	c.1885_1886CC>TT	p.P629F	Substitution - Missense	Skin
COSM5965726	c.3235G>A	p.E1079K	Substitution - Missense	Breast
COSM5802651	c.3297T>A	p.G1099G	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM285940	c.2593C>T	p.R865*	Substitution - Nonsense	Endometrium
COSM674238	c.1364G>C	p.G455A	Substitution - Missense	Lung
COSM3750243	c.1146A>G	p.Q382Q	Substitution - coding silent	Soft_tissue
COSM4760395	c.701G>A	p.G234E	Substitution - Missense	Stomach
COSM5461936	c.833T>C	p.V278A	Substitution - Missense	Large_intestine
COSM3750243	c.1146A>G	p.Q382Q	Substitution - coding silent	Soft_tissue
COSM3750243	c.1146A>G	p.Q382Q	Substitution - coding silent	Soft_tissue
COSM1332871	c.2981A>G	p.Y994C	Substitution - Missense	Large_intestine
COSM2177191	c.2414G>A	p.C805Y	Substitution - Missense	Upper_aerodigestive_tract
COSM3688905	c.2896T>C	p.C966R	Substitution - Missense	Large_intestine
COSM12939	c.2431G>A	p.E811K	Substitution - Missense	Lung
COSM5377262	c.2278A>G	p.T760A	Substitution - Missense	Skin
COSM4957872	c.1417T>G	p.L473V	Substitution - Missense	Liver
COSM894185	c.1285C>T	p.L429L	Substitution - coding silent	Endometrium
COSM13372	c.1740G>A	p.M580I	Substitution - Missense	Central_nervous_system
COSM5023821	c.857delT	p.F287fs*8	Deletion - Frameshift	Bone
COSM4020866	c.1372C>T	p.R458C	Substitution - Missense	Stomach
COSM265245	c.809G>C	p.G270A	Substitution - Missense	Large_intestine
COSM13372	c.1740G>A	p.M580I	Substitution - Missense	Central_nervous_system
COSM4408161	c.983C>T	p.A328V	Substitution - Missense	Pancreas
COSM5560583	c.2150T>G	p.M717R	Substitution - Missense	Prostate
COSM3667314	c.3047A>T	p.Q1016L	Substitution - Missense	Liver
COSM894175	c.2865G>A	p.A955A	Substitution - coding silent	Endometrium
COSM894173	c.2966C>T	p.S989L	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM894189	c.820G>A	p.V274I	Substitution - Missense	Endometrium
COSM4736052	c.1928C>T	p.T643M	Substitution - Missense	Large_intestine
COSM4606748	c.1652A>G	p.Q551R	Substitution - Missense	Adrenal_gland
COSM1600585	c.267T>C	p.V89V	Substitution - coding silent	Liver
COSM3801353	c.1338G>A	p.R446R	Substitution - coding silent	Breast
COSM3471582	c.768C>T	p.I256I	Substitution - coding silent	Skin
COSM133957	c.815G>A	p.R272H	Substitution - Missense	Skin
COSM4020876	c.539G>A	p.R180Q	Substitution - Missense	Stomach
COSM894171	c.3099G>T	p.K1033N	Substitution - Missense	Endometrium
COSM4538012	c.2493G>A	p.L831L	Substitution - coding silent	Skin
COSM3750243	c.1146A>G	p.Q382Q	Substitution - coding silent	Soft_tissue
COSM285940	c.2593C>T	p.R865*	Substitution - Nonsense	Large_intestine
COSM6188	c.2968-1G>C	p.?	Unknown	Breast
COSM2157079	c.1319G>A	p.R440H	Substitution - Missense	Central_nervous_system
COSM4020854	c.3225T>C	p.D1075D	Substitution - coding silent	Stomach
COSM95404	c.379G>A	p.V127M	Substitution - Missense	Lung
COSM894173	c.2966C>T	p.S989L	Substitution - Missense	Endometrium
COSM5667895	c.120G>T	p.A40A	Substitution - coding silent	Soft_tissue
COSM5575966	c.817C>A	p.P273T	Substitution - Missense	Stomach
COSM5562858	c.2129C>T	p.P710L	Substitution - Missense	Prostate
COSM4004714	c.1028A>C	p.Q343P	Substitution - Missense	Ovary
COSM165131	c.1329G>C	p.L443F	Substitution - Missense	Breast
COSM1559268	c.157G>T	p.A53S	Substitution - Missense	Central_nervous_system
COSM894174	c.2903G>A	p.R968H	Substitution - Missense	Oesophagus
COSM5377267	c.972G>A	p.E324E	Substitution - coding silent	Skin
COSM258629	c.1002_1004delGAA	p.K334delK	Deletion - In frame	Large_intestine
COSM1315894	c.1675C>A	p.P559T	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3750243	c.1146A>G	p.Q382Q	Substitution - coding silent	Large_intestine
COSM894170	c.3233C>T	p.T1078I	Substitution - Missense	Endometrium
COSM894188	c.984G>A	p.A328A	Substitution - coding silent	Large_intestine
COSM4769480	c.3123G>A	p.M1041I	Substitution - Missense	Biliary_tract
COSM1626325	c.868A>C	p.T290P	Substitution - Missense	Liver
COSM1268530	c.2676C>G	p.V892V	Substitution - coding silent	Oesophagus
COSM1127464	c.861C>T	p.F287F	Substitution - coding silent	Prostate
COSM12939	c.2431G>A	p.E811K	Substitution - Missense	Lung
COSM5019221	c.1303-10delT	p.?	Unknown	Soft_tissue
COSM3700459	c.2988T>C	p.I996I	Substitution - coding silent	Liver
COSM894179	c.2605C>T	p.H869Y	Substitution - Missense	Kidney
COSM5019221	c.1303-10delT	p.?	Unknown	Soft_tissue
COSM1315893	c.1676C>A	p.P559H	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3471575	c.2098C>T	p.L700L	Substitution - coding silent	Skin
COSM1600584	c.915A>G	p.K305K	Substitution - coding silent	Liver
COSM5742747	c.1924C>A	p.P642T	Substitution - Missense	Small_intestine
COSM1332873	c.2864C>T	p.A955V	Substitution - Missense	Large_intestine
COSM5547881	c.1155+2_1155+11delTATGGTTCAA	p.?	Unknown	Prostate
COSM5571723	c.1899A>T	p.V633V	Substitution - coding silent	Prostate
COSM4736062	c.1232A>G	p.H411R	Substitution - Missense	Large_intestine
COSM4453493	c.3032A>G	p.Q1011R	Substitution - Missense	Skin
COSM894180	c.2399G>A	p.G800D	Substitution - Missense	Endometrium
COSM1559266	c.1887C>A	p.P629P	Substitution - coding silent	Central_nervous_system
COSM4189106	c.2801T>C	p.I934T	Substitution - Missense	Kidney
COSM4020852	c.3232A>G	p.T1078A	Substitution - Missense	Stomach
COSM5019221	c.1303-10delT	p.?	Unknown	Soft_tissue
COSM285940	c.2593C>T	p.R865*	Substitution - Nonsense	Large_intestine
COSM1320121	c.2464C>G	p.L822V	Substitution - Missense	Ovary
COSM4593689	c.1136C>G	p.S379C	Substitution - Missense	Upper_aerodigestive_tract
COSM5622045	c.2201C>T	p.S734F	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1600585	c.267T>C	p.V89V	Substitution - coding silent	Liver
COSM1559266	c.1887C>A	p.P629P	Substitution - coding silent	Central_nervous_system
COSM1559266	c.1887C>A	p.P629P	Substitution - coding silent	Central_nervous_system
COSM894188	c.984G>A	p.A328A	Substitution - coding silent	Endometrium
COSM303448	c.1389C>A	p.P463P	Substitution - coding silent	Central_nervous_system
COSM3671353	c.3085C>T	p.R1029C	Substitution - Missense	Prostate
COSM6188	c.2968-1G>C	p.?	Unknown	Breast
COSM13373	c.2653C>T	p.P885S	Substitution - Missense	Central_nervous_system
COSM4957872	c.1417T>G	p.L473V	Substitution - Missense	Liver
COSM5562858	c.2129C>T	p.P710L	Substitution - Missense	Prostate
COSM367980	c.3086G>A	p.R1029H	Substitution - Missense	Lung
COSM3750243	c.1146A>G	p.Q382Q	Substitution - coding silent	Soft_tissue
COSM894182	c.2037G>A	p.S679S	Substitution - coding silent	Oesophagus
COSM3471580	c.1114G>T	p.E372*	Substitution - Nonsense	Skin
COSM4852043	c.1612C>A	p.Q538K	Substitution - Missense	Cervix
COSM5724594	c.2406G>T	p.R802S	Substitution - Missense	Skin
COSM4020870	c.1143A>G	p.L381L	Substitution - coding silent	Stomach
COSM5789663	c.3337C>T	p.R1113C	Substitution - Missense	Breast
COSM5016740	c.3160_3161insA	p.I1054fs*2	Insertion - Frameshift	Kidney
COSM3801356	c.570G>T	p.Q190H	Substitution - Missense	Breast
COSM2177142	c.3258C>T	p.F1086F	Substitution - coding silent	Stomach
COSM4616417	c.1837A>G	p.M613V	Substitution - Missense	Large_intestine
COSM1472437	c.2923T>C	p.C975R	Substitution - Missense	Breast
COSM894183	c.1870C>T	p.P624S	Substitution - Missense	Endometrium
COSM5672443	c.100G>T	p.A34S	Substitution - Missense	Soft_tissue
COSM4410460	c.1041-8T>G	p.?	Unknown	Oesophagus
COSM4020856	c.2184G>T	p.P728P	Substitution - coding silent	Stomach
COSM3750243	c.1146A>G	p.Q382Q	Substitution - coding silent	Soft_tissue
COSM1332873	c.2864C>T	p.A955V	Substitution - Missense	Liver
COSM5575609	c.1231C>T	p.H411Y	Substitution - Missense	Stomach
COSM3750243	c.1146A>G	p.Q382Q	Substitution - coding silent	Soft_tissue
COSM3471573	c.3084C>T	p.V1028V	Substitution - coding silent	Skin
COSM95403	c.1812G>T	p.R604S	Substitution - Missense	Lung
COSM5003014	c.2714G>T	p.C905F	Substitution - Missense	Pancreas
COSM3471577	c.1963C>G	p.R655G	Substitution - Missense	Skin
COSM12939	c.2431G>A	p.E811K	Substitution - Missense	Lung
COSM222542	c.847C>T	p.Q283*	Substitution - Nonsense	Skin
COSM3385047	c.2525C>T	p.P842L	Substitution - Missense	Pancreas
COSM4819243	c.3363G>C	p.E1121D	Substitution - Missense	Cervix
COSM4020860	c.1696-1G>A	p.?	Unknown	Stomach
COSM5745704	c.3304A>G	p.T1102A	Substitution - Missense	Pancreas
COSM4654659	c.1842G>A	p.Q614Q	Substitution - coding silent	Large_intestine
COSM5019221	c.1303-10delT	p.?	Unknown	Soft_tissue
COSM4458645	c.1094C>T	p.A365V	Substitution - Missense	Skin
COSM894179	c.2605C>T	p.H869Y	Substitution - Missense	Endometrium
COSM5377265	c.1537C>T	p.Q513*	Substitution - Nonsense	Skin
COSM1626323	c.2127A>T	p.L709L	Substitution - coding silent	Liver
COSM1728870	c.493A>T	p.I165F	Substitution - Missense	Liver
COSM4736049	c.2132delC	p.P711fs*7	Deletion - Frameshift	Large_intestine
COSM4486392	c.3046C>A	p.Q1016K	Substitution - Missense	Skin
COSM21194	c.3255C>T	p.T1085T	Substitution - coding silent	Skin
COSM20449	c.3039_3040insA	p.H1014fs*10	Insertion - Frameshift	Large_intestine
COSM1491617	c.2419-2A>T	p.?	Unknown	Kidney
COSM78697	c.1807C>T	p.P603S	Substitution - Missense	Ovary
COSM21194	c.3255C>T	p.T1085T	Substitution - coding silent	Skin
COSM2177186	c.2554T>A	p.S852T	Substitution - Missense	Large_intestine
COSM674236	c.1218C>T	p.S406S	Substitution - coding silent	Lung
COSM1667835	c.2654C>T	p.P885L	Substitution - Missense	Large_intestine
COSM1727638	c.1384G>A	p.D462N	Substitution - Missense	Liver
COSM5724594	c.2406G>T	p.R802S	Substitution - Missense	Skin
COSM4736054	c.1903G>A	p.V635I	Substitution - Missense	Large_intestine
COSM303449	c.2958delT	p.P987fs*11	Deletion - Frameshift	Central_nervous_system
COSM4565351	c.2005_2006CC>TT	p.P669F	Substitution - Missense	Skin
COSM4736060	c.1239G>T	p.M413I	Substitution - Missense	Large_intestine
COSM4020874	c.554G>A	p.R185H	Substitution - Missense	Stomach
COSM4637610	c.2959C>G	p.P987A	Substitution - Missense	Large_intestine

> Text Mining based Variations [ TOP ]
There is no record for TRIM33.

Summary
Symbol	TRIM33
Name	tripartite motif containing 33
Aliases	TIF1GAMMA; FLJ11429; KIAA1113; TIFGAMMA; RFG7; TF1G; TIF1G; PTC7; transcriptional intermediary factor 1 gamm ......
Location	1p13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

[ TOP ]

Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
Q9UPN9	515	R	Omega-N-methylarginine	-	No	None detected
Q9UPN9	535	R	Omega-N-methylarginine	-	No	None detected
Q9UPN9	577	R	Asymmetric dimethylarginine	-	No	None detected
Q9UPN9	591	R	Asymmetric dimethylarginine	-	No	None detected
Q9UPN9	591	R	Omega-N-methylarginine	-	No	None detected
Q9UPN9	598	R	Asymmetric dimethylarginine	-	No	None detected
Q9UPN9	604	R	Asymmetric dimethylarginine	-	No	None detected
Q9UPN9	763	K	N6-acetyllysine	-	No	None detected
Q9UPN9	769	K	N6-acetyllysine	-	No	None detected
Q9UPN9	793	K	N6-acetyllysine	-	No	None detected
Q9UPN9	803	S	Phosphoserine	-	No	None detected
Q9UPN9	815	T	Phosphothreonine	-	No	None detected
Q9UPN9	862	S	Phosphoserine	-	No	None detected
Q9UPN9	951	K	N6-acetyllysine	-	No	None detected
Q9UPN9	953	K	N6-acetyllysine	-	No	None detected
Q9UPN9	1051	T	Phosphothreonine	-	No	None detected
Q9UPN9	1102	T	Phosphothreonine	-	No	None detected
Q9UPN9	1105	S	Phosphoserine	-	No	None detected
Q9UPN9	1119	S	Phosphoserine	-	No	None detected

Summary
Symbol	TRIM33
Name	tripartite motif containing 33
Aliases	TIF1GAMMA; FLJ11429; KIAA1113; TIFGAMMA; RFG7; TF1G; TIF1G; PTC7; transcriptional intermediary factor 1 gamm ......
Location	1p13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	5.891	5.802	-0.088	0.633	NS
BRCA	Breast invasive carcinoma	112	1100	6.175	6.095	-0.01	0.876	NS
CESC	Cervical and endocervical cancers	3	306	5.712	5.675	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	5.24	5.359	-0.003	0.979	NS
ESCA	Esophageal carcinoma	11	185	6.631	6.509	-0.13	0.518	NS
GBM	Glioblastoma multiforme	5	166	6.244	5.551	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	5.527	5.259	-0.337	0.000225	NS
KIRC	Kidney renal clear cell carcinoma	72	534	6.173	5.647	-0.497	3.11e-22	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	5.864	5.276	-0.546	6.54e-08	NS
LAML	Acute Myeloid Leukemia	0	173	NA	7.495	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	5.89	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	4.594	4.49	-0.05	0.596	NS
LUAD	Lung adenocarcinoma	59	517	5.782	5.678	-0.033	0.668	NS
LUSC	Lung squamous cell carcinoma	51	501	5.527	5.479	-0.066	0.383	NS
OV	Ovarian serous cystadenocarcinoma	0	307	NA	6.215	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	5.547	5.289	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	4.981	4.766	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	5.996	6.079	0.079	0.367	NS
READ	Rectum adenocarcinoma	10	167	5.367	5.29	-0.073	0.789	NS
SARC	Sarcoma	2	263	5.096	5.027	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	5.587	5.528	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	5.898	6.441	0.372	6.14e-05	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	5.874	NA	NA	NA
THCA	Thyroid carcinoma	59	509	5.982	5.807	-0.114	0.0245	NS
THYM	Thymoma	2	120	5.926	5.29	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	5.88	5.524	-0.331	0.00574	NS

> Cancer Cell Line Encyclopedia (CCLE)

[ TOP ]

Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	9.4
Autonomic ganglia	CHP212	8.7
Autonomic ganglia	IMR32	10
Autonomic ganglia	KELLY	9.7
Autonomic ganglia	KPNRTBM1	9.6
Autonomic ganglia	KPNSI9S	8.4
Autonomic ganglia	KPNYN	9.5
Autonomic ganglia	MHHNB11	10
Autonomic ganglia	NB1	9.8
Autonomic ganglia	NH6	9
Autonomic ganglia	SHSY5Y	9.1
Autonomic ganglia	SIMA	9.4
Autonomic ganglia	SKNAS	8.6
Autonomic ganglia	SKNBE2	8.5
Autonomic ganglia	SKNDZ	9.2
Autonomic ganglia	SKNFI	8.8
Autonomic ganglia	SKNSH	8.3
Biliary tract	HUCCT1	8.8
Biliary tract	HUH28	9
Biliary tract	SNU1079	9.9
Biliary tract	SNU1196	8.5
Biliary tract	SNU245	8.8
Biliary tract	SNU308	9.7
Biliary tract	SNU478	9.2
Bone	143B	10
Bone	A673	9.1
Bone	CADOES1	9.4
Bone	CAL78	8.3
Bone	G292CLONEA141B1	8.8
Bone	HOS	8.7
Bone	HS706T	8
Bone	HS737T	8
Bone	HS819T	7.7
Bone	HS821T	8.2
Bone	HS822T	7.8
Bone	HS863T	8.1
Bone	HS870T	8.1
Bone	HS888T	8.6
Bone	MG63	8.8
Bone	MHHES1	9.8
Bone	OUMS27	8
Bone	RDES	10.3
Bone	SJSA1	8.4
Bone	SKES1	10.1
Bone	SKNMC	9.6
Bone	SW1353	8.5
Bone	T173	8
Bone	TC71	8.7
Bone	U2OS	9.3
Breast	AU565	9.8
Breast	BT20	10.7
Breast	BT474	9.2
Breast	BT483	9.5
Breast	BT549	8.7
Breast	CAL120	8.9
Breast	CAL148	9.4
Breast	CAL51	9.6
Breast	CAL851	8.7
Breast	CAMA1	9.2
Breast	DU4475	9.3
Breast	EFM192A	9.3
Breast	EFM19	9.2
Breast	EVSAT	9
Breast	HCC1143	9.1
Breast	HCC1187	8.5
Breast	HCC1395	8.1
Breast	HCC1419	9.3
Breast	HCC1428	10
Breast	HCC1500	8.7
Breast	HCC1569	8.5
Breast	HCC1599	9.7
Breast	HCC1806	8.7
Breast	HCC1937	9.5
Breast	HCC1954	8.8
Breast	HCC202	9
Breast	HCC2157	9.1
Breast	HCC2218	8.8
Breast	HCC38	9
Breast	HCC70	9.5
Breast	HDQP1	9.1
Breast	HMC18	8.6
Breast	HS274T	8.3
Breast	HS281T	8.4
Breast	HS343T	8.3
Breast	HS578T	8.3
Breast	HS606T	8
Breast	HS739T	8.3
Breast	HS742T	8
Breast	JIMT1	7.9
Breast	KPL1	11.9
Breast	MCF7	10.7
Breast	MDAMB134VI	9.4
Breast	MDAMB157	8.4
Breast	MDAMB175VII	8.3
Breast	MDAMB231	8.9
Breast	MDAMB361	8.7
Breast	MDAMB415	8.9
Breast	MDAMB436	8.6
Breast	MDAMB453	9.1
Breast	MDAMB468	9.5
Breast	SKBR3	9.6
Breast	T47D	8.5
Breast	UACC812	9
Breast	UACC893	8
Breast	YMB1	8.5
Breast	ZR751	8.3
Breast	ZR7530	9.5
Central nervous system	1321N1	8.7
Central nervous system	42MGBA	8.9
Central nervous system	8MGBA	9.2
Central nervous system	A172	8.2
Central nervous system	AM38	8.5
Central nervous system	BECKER	8
Central nervous system	CAS1	8.2
Central nervous system	CCFSTTG1	8.2
Central nervous system	D283MED	9
Central nervous system	D341MED	9.2
Central nervous system	DAOY	9.4
Central nervous system	DBTRG05MG	8
Central nervous system	DKMG	8.3
Central nervous system	GAMG	8.6
Central nervous system	GB1	9.5
Central nervous system	GI1	8.9
Central nervous system	GMS10	8.5
Central nervous system	GOS3	8.5
Central nervous system	H4	7.7
Central nervous system	HS683	8.6
Central nervous system	KALS1	9
Central nervous system	KG1C	8
Central nervous system	KNS42	9
Central nervous system	KNS60	8.5
Central nervous system	KNS81	8.7
Central nervous system	KS1	8.4
Central nervous system	LN18	8.1
Central nervous system	LN229	8.1
Central nervous system	M059K	8.4
Central nervous system	MOGGCCM	8.6
Central nervous system	MOGGUVW	8.5
Central nervous system	NMCG1	8.5
Central nervous system	ONS76	9.2
Central nervous system	SF126	8.1
Central nervous system	SF295	8.1
Central nervous system	SNB19	8.5
Central nervous system	SNU1105	8.7
Central nervous system	SNU201	8.4
Central nervous system	SNU466	8
Central nervous system	SNU489	8.3
Central nervous system	SNU626	8.7
Central nervous system	SNU738	9.4
Central nervous system	SW1088	8.6
Central nervous system	SW1783	8.2
Central nervous system	T98G	8.7
Central nervous system	TM31	9.1
Central nervous system	U118MG	8.8
Central nervous system	U138MG	8
Central nervous system	U251MG	8.7
Central nervous system	U87MG	8.8
Central nervous system	YH13	8.6
Central nervous system	YKG1	8.8
Endometrium	AN3CA	8.9
Endometrium	COLO684	9
Endometrium	EFE184	9.2
Endometrium	EN	8.8
Endometrium	ESS1	8.8
Endometrium	HEC108	8.8
Endometrium	HEC151	8.7
Endometrium	HEC1A	8.9
Endometrium	HEC1B	9.4
Endometrium	HEC251	9.6
Endometrium	HEC265	8.3
Endometrium	HEC50B	8.8
Endometrium	HEC59	9.6
Endometrium	HEC6	9.2
Endometrium	ISHIKAWAHERAKLIO02ER	9.3
Endometrium	JHUEM1	9.1
Endometrium	JHUEM2	9.3
Endometrium	JHUEM3	9
Endometrium	KLE	7.7
Endometrium	MFE280	9.5
Endometrium	MFE296	8.8
Endometrium	MFE319	9.2
Endometrium	RL952	9
Endometrium	SNGM	9
Endometrium	SNU1077	9.2
Endometrium	SNU685	9.3
Endometrium	TEN	8.9
Haematopoietic and lymphoid	697	9.9
Haematopoietic and lymphoid	A3KAW	8.9
Haematopoietic and lymphoid	A4FUK	9
Haematopoietic and lymphoid	ALLSIL	9.6
Haematopoietic and lymphoid	AML193	9
Haematopoietic and lymphoid	AMO1	7.5
Haematopoietic and lymphoid	BCP1	8.2
Haematopoietic and lymphoid	BDCM	8.7
Haematopoietic and lymphoid	BL41	9.3
Haematopoietic and lymphoid	BL70	9.3
Haematopoietic and lymphoid	BV173	9.9
Haematopoietic and lymphoid	CA46	9.1
Haematopoietic and lymphoid	CI1	9.4
Haematopoietic and lymphoid	CMK115	9.3
Haematopoietic and lymphoid	CMK86	9.9
Haematopoietic and lymphoid	CMK	9.5
Haematopoietic and lymphoid	CMLT1	9.8
Haematopoietic and lymphoid	COLO775	8.6
Haematopoietic and lymphoid	DAUDI	9.6
Haematopoietic and lymphoid	DB	9.6
Haematopoietic and lymphoid	DEL	8.5
Haematopoietic and lymphoid	DND41	9.4
Haematopoietic and lymphoid	DOHH2	9.5
Haematopoietic and lymphoid	EB1	9.4
Haematopoietic and lymphoid	EB2	9.6
Haematopoietic and lymphoid	EHEB	9.4
Haematopoietic and lymphoid	EJM	9.2
Haematopoietic and lymphoid	EM2	9.1
Haematopoietic and lymphoid	EOL1	9.4
Haematopoietic and lymphoid	F36P	9.7
Haematopoietic and lymphoid	GA10	9.4
Haematopoietic and lymphoid	GDM1	9.4
Haematopoietic and lymphoid	GRANTA519	8.2
Haematopoietic and lymphoid	HDLM2	9.3
Haematopoietic and lymphoid	HDMYZ	8.5
Haematopoietic and lymphoid	HEL9217	9.3
Haematopoietic and lymphoid	HEL	9.2
Haematopoietic and lymphoid	HH	10
Haematopoietic and lymphoid	HL60	9.6
Haematopoietic and lymphoid	HPBALL	9.5
Haematopoietic and lymphoid	HS604T	8.4
Haematopoietic and lymphoid	HS611T	8.8
Haematopoietic and lymphoid	HS616T	8.1
Haematopoietic and lymphoid	HS751T	8.1
Haematopoietic and lymphoid	HT	9.4
Haematopoietic and lymphoid	HTK	9.7
Haematopoietic and lymphoid	HUNS1	8.7
Haematopoietic and lymphoid	HUT102	8.7
Haematopoietic and lymphoid	HUT78	9.1
Haematopoietic and lymphoid	JEKO1	8.9
Haematopoietic and lymphoid	JK1	10.1
Haematopoietic and lymphoid	JM1	9.4
Haematopoietic and lymphoid	JURKAT	9.6
Haematopoietic and lymphoid	JURLMK1	9.2
Haematopoietic and lymphoid	JVM2	9.1
Haematopoietic and lymphoid	JVM3	9
Haematopoietic and lymphoid	K562	9.3
Haematopoietic and lymphoid	KARPAS299	8.8
Haematopoietic and lymphoid	KARPAS422	9.6
Haematopoietic and lymphoid	KARPAS620	8.8
Haematopoietic and lymphoid	KASUMI1	9.2
Haematopoietic and lymphoid	KASUMI2	9.6
Haematopoietic and lymphoid	KASUMI6	9.3
Haematopoietic and lymphoid	KCL22	9.1
Haematopoietic and lymphoid	KE37	10
Haematopoietic and lymphoid	KE97	9
Haematopoietic and lymphoid	KG1	9.1
Haematopoietic and lymphoid	KHM1B	8.5
Haematopoietic and lymphoid	KIJK	8.5
Haematopoietic and lymphoid	KMH2	9.3
Haematopoietic and lymphoid	KMM1	8.1
Haematopoietic and lymphoid	KMS11	8.5
Haematopoietic and lymphoid	KMS12BM	8.9
Haematopoietic and lymphoid	KMS18	9.4
Haematopoietic and lymphoid	KMS20	8.7
Haematopoietic and lymphoid	KMS21BM	8.6
Haematopoietic and lymphoid	KMS26	8.2
Haematopoietic and lymphoid	KMS27	8.7
Haematopoietic and lymphoid	KMS28BM	8.1
Haematopoietic and lymphoid	KMS34	8.8
Haematopoietic and lymphoid	KO52	9.9
Haematopoietic and lymphoid	KOPN8	9.2
Haematopoietic and lymphoid	KU812	10.3
Haematopoietic and lymphoid	KYO1	9.3
Haematopoietic and lymphoid	L1236	9.3
Haematopoietic and lymphoid	L363	9.8
Haematopoietic and lymphoid	L428	10.4
Haematopoietic and lymphoid	L540	8.7
Haematopoietic and lymphoid	LAMA84	9.5
Haematopoietic and lymphoid	LOUCY	9.5
Haematopoietic and lymphoid	LP1	8.5
Haematopoietic and lymphoid	M07E	10.3
Haematopoietic and lymphoid	MC116	9.4
Haematopoietic and lymphoid	ME1	8.3
Haematopoietic and lymphoid	MEC1	9.5
Haematopoietic and lymphoid	MEC2	9.2
Haematopoietic and lymphoid	MEG01	9.5
Haematopoietic and lymphoid	MHHCALL2	9.7
Haematopoietic and lymphoid	MHHCALL3	9.8
Haematopoietic and lymphoid	MHHCALL4	9.7
Haematopoietic and lymphoid	MINO	9.6
Haematopoietic and lymphoid	MJ	9.4
Haematopoietic and lymphoid	MM1S	7.9
Haematopoietic and lymphoid	MOLM13	9.2
Haematopoietic and lymphoid	MOLM16	10.1
Haematopoietic and lymphoid	MOLM6	9.8
Haematopoietic and lymphoid	MOLP2	8
Haematopoietic and lymphoid	MOLP8	9.3
Haematopoietic and lymphoid	MOLT13	10.1
Haematopoietic and lymphoid	MOLT16	9.9
Haematopoietic and lymphoid	MOLT4	9.5
Haematopoietic and lymphoid	MONOMAC1	9.1
Haematopoietic and lymphoid	MONOMAC6	9.3
Haematopoietic and lymphoid	MOTN1	9.1
Haematopoietic and lymphoid	MUTZ5	9.4
Haematopoietic and lymphoid	MV411	9.2
Haematopoietic and lymphoid	NALM19	9.3
Haematopoietic and lymphoid	NALM1	9.9
Haematopoietic and lymphoid	NALM6	9.4
Haematopoietic and lymphoid	NAMALWA	9.6
Haematopoietic and lymphoid	NB4	9.3
Haematopoietic and lymphoid	NCIH929	8.2
Haematopoietic and lymphoid	NCO2	9.7
Haematopoietic and lymphoid	NOMO1	9
Haematopoietic and lymphoid	NUDHL1	8.8
Haematopoietic and lymphoid	NUDUL1	9.9
Haematopoietic and lymphoid	OCIAML2	9.4
Haematopoietic and lymphoid	OCIAML3	8.9
Haematopoietic and lymphoid	OCIAML5	9.3
Haematopoietic and lymphoid	OCILY10	9.5
Haematopoietic and lymphoid	OCILY19	9.7
Haematopoietic and lymphoid	OCILY3	8.6
Haematopoietic and lymphoid	OCIM1	10.3
Haematopoietic and lymphoid	OPM2	7.5
Haematopoietic and lymphoid	P12ICHIKAWA	10
Haematopoietic and lymphoid	P31FUJ	8.7
Haematopoietic and lymphoid	P3HR1	9.2
Haematopoietic and lymphoid	PCM6	8.8
Haematopoietic and lymphoid	PEER	9.6
Haematopoietic and lymphoid	PF382	10.1
Haematopoietic and lymphoid	PFEIFFER	9.3
Haematopoietic and lymphoid	PL21	9.4
Haematopoietic and lymphoid	RAJI	9.3
Haematopoietic and lymphoid	RCHACV	9.7
Haematopoietic and lymphoid	REC1	9.5
Haematopoietic and lymphoid	REH	9.5
Haematopoietic and lymphoid	RI1	8.7
Haematopoietic and lymphoid	RL	9.3
Haematopoietic and lymphoid	RPMI8226	8
Haematopoietic and lymphoid	RPMI8402	10.1
Haematopoietic and lymphoid	RS411	9.3
Haematopoietic and lymphoid	SEM	9.6
Haematopoietic and lymphoid	SET2	9.6
Haematopoietic and lymphoid	SIGM5	9.2
Haematopoietic and lymphoid	SKM1	8.7
Haematopoietic and lymphoid	SKMM2	9.4
Haematopoietic and lymphoid	SR786	8.9
Haematopoietic and lymphoid	ST486	9.2
Haematopoietic and lymphoid	SUDHL10	9.4
Haematopoietic and lymphoid	SUDHL1	8.5
Haematopoietic and lymphoid	SUDHL4	8.9
Haematopoietic and lymphoid	SUDHL5	9.5
Haematopoietic and lymphoid	SUDHL6	9.8
Haematopoietic and lymphoid	SUDHL8	9.1
Haematopoietic and lymphoid	SUPB15	8.7
Haematopoietic and lymphoid	SUPHD1	8.9
Haematopoietic and lymphoid	SUPM2	8.5
Haematopoietic and lymphoid	SUPT11	9.6
Haematopoietic and lymphoid	SUPT1	9.6
Haematopoietic and lymphoid	TALL1	10
Haematopoietic and lymphoid	TF1	9.4
Haematopoietic and lymphoid	THP1	9.1
Haematopoietic and lymphoid	TO175T	8.2
Haematopoietic and lymphoid	TOLEDO	9.1
Haematopoietic and lymphoid	U266B1	8.7
Haematopoietic and lymphoid	U937	9.3
Haematopoietic and lymphoid	UT7	10.2
Haematopoietic and lymphoid	WSUDLCL2	9.4
Kidney	769P	8.9
Kidney	786O	8.7
Kidney	A498	8.5
Kidney	A704	8.7
Kidney	ACHN	8.5
Kidney	BFTC909	8.1
Kidney	CAKI1	8.5
Kidney	CAKI2	8.4
Kidney	CAL54	8.6
Kidney	KMRC1	8.8
Kidney	KMRC20	8.8
Kidney	KMRC2	8.9
Kidney	KMRC3	8.6
Kidney	OSRC2	8.4
Kidney	RCC10RGB	8.5
Kidney	SNU1272	8.8
Kidney	SNU349	7.8
Kidney	TUHR10TKB	8.8
Kidney	TUHR14TKB	9.2
Kidney	TUHR4TKB	8.8
Kidney	VMRCRCW	8.4
Kidney	VMRCRCZ	9
Large intestine	C2BBE1	8.1
Large intestine	CCK81	8.3
Large intestine	CL11	9.4
Large intestine	CL14	9.3
Large intestine	CL34	9.4
Large intestine	CL40	8.9
Large intestine	COLO205	8.3
Large intestine	COLO320	9.5
Large intestine	COLO678	9.4
Large intestine	CW2	9.1
Large intestine	DLD1	9.1
Large intestine	GP2D	9.7
Large intestine	HCC56	8.3
Large intestine	HCT116	9.1
Large intestine	HCT15	9.2
Large intestine	HS675T	7.9
Large intestine	HS698T	8.5
Large intestine	HT115	8.9
Large intestine	HT29	9.1
Large intestine	HT55	9.6
Large intestine	KM12	9.2
Large intestine	LOVO	8.8
Large intestine	LS1034	8.9
Large intestine	LS123	8.9
Large intestine	LS180	8.4
Large intestine	LS411N	8.9
Large intestine	LS513	8.7
Large intestine	MDST8	7.4
Large intestine	NCIH508	8.6
Large intestine	NCIH716	8.8
Large intestine	NCIH747	8.3
Large intestine	OUMS23	10
Large intestine	RCM1	8.9
Large intestine	RKO	8.9
Large intestine	SKCO1	9.7
Large intestine	SNU1040	9.5
Large intestine	SNU1197	8.8
Large intestine	SNU175	9.3
Large intestine	SNU283	9.1
Large intestine	SNU407	9.4
Large intestine	SNU503	7.9
Large intestine	SNU61	8.6
Large intestine	SNU81	9.5
Large intestine	SNUC1	9.1
Large intestine	SNUC2A	8.1
Large intestine	SNUC4	7
Large intestine	SNUC5	9.3
Large intestine	SW1116	8.6
Large intestine	SW1417	8.3
Large intestine	SW1463	9.1
Large intestine	SW403	9.2
Large intestine	SW480	8.5
Large intestine	SW48	9.8
Large intestine	SW620	9.2
Large intestine	SW837	8.5
Large intestine	SW948	8.9
Large intestine	T84	9.1
Liver	ALEXANDERCELLS	8.1
Liver	C3A	8.8
Liver	HEP3B217	9.1
Liver	HEPG2	9.4
Liver	HLE	8.7
Liver	HLF	8.3
Liver	HUH1	8.3
Liver	HUH6	9.3
Liver	HUH7	8.7
Liver	JHH1	8.2
Liver	JHH2	8.4
Liver	JHH4	8.8
Liver	JHH5	9
Liver	JHH6	8.8
Liver	JHH7	9
Liver	LI7	8.3
Liver	PLCPRF5	8.2
Liver	SKHEP1	8.6
Liver	SNU182	8.5
Liver	SNU387	9.1
Liver	SNU398	9.2
Liver	SNU423	8.6
Liver	SNU449	8.2
Liver	SNU475	8.8
Liver	SNU761	9
Liver	SNU878	8.3
Liver	SNU886	9.2
Lung	A549	7.8
Lung	ABC1	8.7
Lung	BEN	8.3
Lung	CAL12T	8.4
Lung	CALU1	8.6
Lung	CALU3	9.1
Lung	CALU6	8.5
Lung	CHAGOK1	7.7
Lung	COLO668	9.4
Lung	COLO699	9.5
Lung	CORL105	9.2
Lung	CORL23	9
Lung	CORL24	9.7
Lung	CORL279	9.6
Lung	CORL311	9.6
Lung	CORL47	8.7
Lung	CORL51	9.3
Lung	CORL88	9.5
Lung	CORL95	9
Lung	CPCN	8.9
Lung	DMS114	9.4
Lung	DMS153	9
Lung	DMS273	9.1
Lung	DMS454	8.4
Lung	DMS53	8.9
Lung	DMS79	9.9
Lung	DV90	9.2
Lung	EBC1	8.6
Lung	EPLC272H	7.9
Lung	HARA	8.7
Lung	HCC1171	8.6
Lung	HCC1195	10.8
Lung	HCC15	8.7
Lung	HCC2279	8.8
Lung	HCC2935	8.8
Lung	HCC33	9.8
Lung	HCC366	9.3
Lung	HCC4006	8.8
Lung	HCC44	8.9
Lung	HCC78	8.9
Lung	HCC827	9.4
Lung	HCC95	7.6
Lung	HLC1	9.1
Lung	HLFA	8.1
Lung	HS229T	8.3
Lung	HS618T	8
Lung	IALM	9.1
Lung	KNS62	8.3
Lung	LC1F	9.6
Lung	LC1SQSF	9
Lung	LCLC103H	8.9
Lung	LCLC97TM1	9.3
Lung	LK2	9
Lung	LOUNH91	8.6
Lung	LU65	8.3
Lung	LU99	9.2
Lung	LUDLU1	8
Lung	LXF289	8.4
Lung	MORCPR	8.9
Lung	NCIH1048	9.3
Lung	NCIH1092	9.5
Lung	NCIH1105	10.4
Lung	NCIH1155	9
Lung	NCIH1184	9
Lung	NCIH1299	8.6
Lung	NCIH1339	9.2
Lung	NCIH1341	9.3
Lung	NCIH1355	8.7
Lung	NCIH1373	8.5
Lung	NCIH1385	9.3
Lung	NCIH1395	8.1
Lung	NCIH1435	9.3
Lung	NCIH1436	9.4
Lung	NCIH1437	9.4
Lung	NCIH146	8.7
Lung	NCIH1563	8.3
Lung	NCIH1568	9.6
Lung	NCIH1573	8.7
Lung	NCIH1581	9.5
Lung	NCIH1618	9.7
Lung	NCIH1623	9.3
Lung	NCIH1648	8.6
Lung	NCIH1650	9.1
Lung	NCIH1651	8.2
Lung	NCIH1666	9
Lung	NCIH1693	6.9
Lung	NCIH1694	10
Lung	NCIH1703	8.4
Lung	NCIH1734	8
Lung	NCIH1755	8.2
Lung	NCIH1781	8.7
Lung	NCIH1792	8.4
Lung	NCIH1793	8.7
Lung	NCIH1836	9.3
Lung	NCIH1838	8.4
Lung	NCIH1869	9.8
Lung	NCIH1876	10.1
Lung	NCIH1915	9.3
Lung	NCIH1930	9
Lung	NCIH1944	8.7
Lung	NCIH1963	9.9
Lung	NCIH196	8.5
Lung	NCIH1975	8.6
Lung	NCIH2009	9
Lung	NCIH2023	8.5
Lung	NCIH2029	8.9
Lung	NCIH2030	7.8
Lung	NCIH2066	8.7
Lung	NCIH2081	8.5
Lung	NCIH2085	8.7
Lung	NCIH2087	9.3
Lung	NCIH209	9.4
Lung	NCIH2106	10
Lung	NCIH2110	8.7
Lung	NCIH211	9.3
Lung	NCIH2122	8.3
Lung	NCIH2126	8.2
Lung	NCIH2141	9.4
Lung	NCIH2170	12.4
Lung	NCIH2171	9.5
Lung	NCIH2172	8.6
Lung	NCIH2196	9.3
Lung	NCIH2227	9.9
Lung	NCIH2228	8.5
Lung	NCIH226	8.7
Lung	NCIH2286	9
Lung	NCIH2291	9
Lung	NCIH2342	9.2
Lung	NCIH2347	8.4
Lung	NCIH23	10
Lung	NCIH2405	9
Lung	NCIH2444	8.6
Lung	NCIH292	8.9
Lung	NCIH322	8.6
Lung	NCIH3255	8.7
Lung	NCIH358	9.5
Lung	NCIH441	8.5
Lung	NCIH446	9.3
Lung	NCIH460	8
Lung	NCIH510	9.4
Lung	NCIH520	8.7
Lung	NCIH522	9.5
Lung	NCIH524	8.9
Lung	NCIH526	10.1
Lung	NCIH596	8.4
Lung	NCIH647	9
Lung	NCIH650	8.5
Lung	NCIH661	8.9
Lung	NCIH69	8.2
Lung	NCIH727	7.7
Lung	NCIH810	9.4
Lung	NCIH82	9.3
Lung	NCIH838	9.8
Lung	NCIH841	9.4
Lung	NCIH854	7.8
Lung	NCIH889	9.4
Lung	PC14	8.7
Lung	RERFLCAD1	8.8
Lung	RERFLCAD2	8.7
Lung	RERFLCAI	8.3
Lung	RERFLCKJ	9.4
Lung	RERFLCMS	8.7
Lung	RERFLCSQ1	8.1
Lung	SBC5	8.5
Lung	SCLC21H	9.6
Lung	SHP77	9.1
Lung	SKLU1	8.5
Lung	SKMES1	8.4
Lung	SQ1	8.8
Lung	SW1271	8.5
Lung	SW1573	9.3
Lung	SW900	8.6
Lung	VMRCLCD	8.9
Lung	VMRCLCP	9.4
Oesophagus	COLO680N	8.8
Oesophagus	ECGI10	8.2
Oesophagus	KYSE140	8.8
Oesophagus	KYSE150	9.1
Oesophagus	KYSE180	9.2
Oesophagus	KYSE270	9.5
Oesophagus	KYSE30	9.4
Oesophagus	KYSE410	8
Oesophagus	KYSE450	8.3
Oesophagus	KYSE510	8.6
Oesophagus	KYSE520	8.3
Oesophagus	KYSE70	8.7
Oesophagus	OE19	8.5
Oesophagus	OE33	10
Oesophagus	TE10	8.5
Oesophagus	TE11	8.8
Oesophagus	TE14	9
Oesophagus	TE15	8.9
Oesophagus	TE1	9.1
Oesophagus	TE4	8.6
Oesophagus	TE5	8.3
Oesophagus	TE6	10.3
Oesophagus	TE8	8.7
Oesophagus	TE9	8.2
Oesophagus	TT	11
Ovary	59M	9.4
Ovary	A2780	9.3
Ovary	CAOV3	8.7
Ovary	CAOV4	8.5
Ovary	COLO704	9.2
Ovary	COV318	9.3
Ovary	COV362	8.4
Ovary	COV434	8.8
Ovary	COV504	8.4
Ovary	COV644	9.1
Ovary	EFO21	9.3
Ovary	EFO27	8.9
Ovary	ES2	8.8
Ovary	FUOV1	9.1
Ovary	HEYA8	8.4
Ovary	HS571T	8.1
Ovary	IGROV1	9
Ovary	JHOC5	9.4
Ovary	JHOM1	8.8
Ovary	JHOM2B	9.4
Ovary	JHOS2	8.7
Ovary	JHOS4	8.8
Ovary	KURAMOCHI	9.8
Ovary	MCAS	9.3
Ovary	NIHOVCAR3	8.9
Ovary	OAW28	9.5
Ovary	OAW42	8.9
Ovary	OC314	8.7
Ovary	OC316	8.7
Ovary	ONCODG1	9.2
Ovary	OV56	8.4
Ovary	OV7	8.6
Ovary	OV90	9
Ovary	OVCAR4	8.3
Ovary	OVCAR8	9.4
Ovary	OVISE	9.1
Ovary	OVK18	8.5
Ovary	OVKATE	8.7
Ovary	OVMANA	9.7
Ovary	OVSAHO	9.4
Ovary	OVTOKO	8.5
Ovary	RMGI	8.2
Ovary	RMUGS	8.2
Ovary	SKOV3	9.4
Ovary	SNU119	10.2
Ovary	SNU840	9.4
Ovary	SNU8	8.9
Ovary	TOV112D	9.1
Ovary	TOV21G	9.2
Ovary	TYKNU	8.7
Pancreas	ASPC1	8.6
Pancreas	BXPC3	9.2
Pancreas	CAPAN1	9.3
Pancreas	CAPAN2	8.1
Pancreas	CFPAC1	8.2
Pancreas	DANG	8.5
Pancreas	HPAC	9.8
Pancreas	HPAFII	9.1
Pancreas	HS766T	9
Pancreas	HUPT3	9.1
Pancreas	HUPT4	9.5
Pancreas	KCIMOH1	9.3
Pancreas	KLM1	8.8
Pancreas	KP2	9.8
Pancreas	KP3	8.5
Pancreas	KP4	9
Pancreas	L33	8.5
Pancreas	MIAPACA2	9.2
Pancreas	PANC0203	9.3
Pancreas	PANC0213	9.4
Pancreas	PANC0327	8.9
Pancreas	PANC0403	8.8
Pancreas	PANC0504	8.8
Pancreas	PANC0813	8.6
Pancreas	PANC1005	9.9
Pancreas	PANC1	8.1
Pancreas	PATU8902	8.5
Pancreas	PATU8988S	8.4
Pancreas	PATU8988T	8.5
Pancreas	PK1	8.7
Pancreas	PK45H	7.6
Pancreas	PK59	8.9
Pancreas	PL45	9.7
Pancreas	PSN1	9.4
Pancreas	QGP1	9.4
Pancreas	SNU213	9.2
Pancreas	SNU324	9.2
Pancreas	SNU410	8.4
Pancreas	SU8686	8.9
Pancreas	SUIT2	9
Pancreas	SW1990	8.3
Pancreas	T3M4	8.8
Pancreas	TCCPAN2	7.9
Pancreas	YAPC	8.7
Pleura	ACCMESO1	8.6
Pleura	DM3	8
Pleura	ISTMES1	8.8
Pleura	ISTMES2	9.2
Pleura	JL1	8.7
Pleura	MPP89	9.2
Pleura	MSTO211H	8.8
Pleura	NCIH2052	8.1
Pleura	NCIH2452	7.9
Pleura	NCIH28	9.2
Prostate	22RV1	8.8
Prostate	DU145	8.2
Prostate	LNCAPCLONEFGC	9
Prostate	MDAPCA2B	9.3
Prostate	NCIH660	9.4
Prostate	PC3	8.5
Prostate	VCAP	9.5
Salivary gland	A253	8.9
Salivary gland	YD15	9
Skin	A101D	9.5
Skin	A2058	9.5
Skin	A375	9
Skin	C32	8.9
Skin	CHL1	9
Skin	CJM	9.5
Skin	COLO679	9.2
Skin	COLO741	9.2
Skin	COLO783	9.1
Skin	COLO792	8
Skin	COLO800	9.1
Skin	COLO818	8.4
Skin	COLO829	9.2
Skin	COLO849	10
Skin	G361	9.2
Skin	GRM	9
Skin	HMCB	8.8
Skin	HS294T	8.6
Skin	HS600T	7.9
Skin	HS688AT	7.7
Skin	HS695T	7.7
Skin	HS839T	7.7
Skin	HS852T	8.8
Skin	HS895T	7.9
Skin	HS934T	8.3
Skin	HS936T	8.8
Skin	HS939T	8.4
Skin	HS940T	8.1
Skin	HS944T	9.2
Skin	HT144	8.2
Skin	IGR1	9.1
Skin	IGR37	9.2
Skin	IGR39	8.6
Skin	IPC298	10
Skin	K029AX	10.2
Skin	LOXIMVI	8.5
Skin	MALME3M	8.5
Skin	MDAMB435S	8.4
Skin	MELHO	10.1
Skin	MELJUSO	9
Skin	MEWO	10
Skin	RPMI7951	8.5
Skin	RVH421	8.5
Skin	SH4	9.7
Skin	SKMEL1	8.2
Skin	SKMEL24	7.7
Skin	SKMEL28	10.3
Skin	SKMEL2	10.3
Skin	SKMEL30	9.7
Skin	SKMEL31	8.8
Skin	SKMEL3	9
Skin	SKMEL5	9.2
Skin	UACC257	9
Skin	UACC62	9.6
Skin	WM115	9.9
Skin	WM1799	8.8
Skin	WM2664	9.8
Skin	WM793	8.6
Skin	WM88	9.7
Skin	WM983B	8.9
Small intestine	HUTU80	9
Soft tissue	A204	8.6
Soft tissue	G401	9
Soft tissue	G402	8.5
Soft tissue	GCT	8.9
Soft tissue	HS729	8.6
Soft tissue	HT1080	8.6
Soft tissue	KYM1	8.6
Soft tissue	MESSA	9.1
Soft tissue	RD	9.2
Soft tissue	RH30	9.5
Soft tissue	RH41	9.1
Soft tissue	RKN	8
Soft tissue	S117	9.2
Soft tissue	SJRH30	8.9
Soft tissue	SKLMS1	8
Soft tissue	SKUT1	8.8
Soft tissue	TE125T	8.3
Soft tissue	TE159T	8.1
Soft tissue	TE441T	9
Soft tissue	TE617T	8.7
Stomach	2313287	8.4
Stomach	AGS	9.1
Stomach	AZ521	9.1
Stomach	ECC10	9.5
Stomach	ECC12	8.9
Stomach	FU97	8.5
Stomach	GCIY	9.5
Stomach	GSS	8.9
Stomach	GSU	9
Stomach	HGC27	8.7
Stomach	HS746T	8.2
Stomach	HUG1N	9
Stomach	IM95	9.1
Stomach	KATOIII	8.4
Stomach	KE39	9.3
Stomach	LMSU	9.1
Stomach	MKN1	8.6
Stomach	MKN45	8.6
Stomach	MKN74	9.2
Stomach	MKN7	8.4
Stomach	NCCSTCK140	9
Stomach	NCIN87	9.3
Stomach	NUGC2	7.9
Stomach	NUGC3	9
Stomach	NUGC4	9.3
Stomach	OCUM1	9.2
Stomach	RERFGC1B	9.2
Stomach	SH10TC	8.4
Stomach	SNU16	9.2
Stomach	SNU1	9.2
Stomach	SNU216	9.1
Stomach	SNU520	9.3
Stomach	SNU5	8.7
Stomach	SNU601	9.5
Stomach	SNU620	9.1
Stomach	SNU668	9.7
Stomach	SNU719	10
Stomach	TGBC11TKB	9.8
Thyroid	8305C	8.2
Thyroid	8505C	9
Thyroid	BCPAP	8.6
Thyroid	BHT101	9.6
Thyroid	CAL62	8.9
Thyroid	CGTHW1	7.9
Thyroid	FTC133	8.3
Thyroid	FTC238	8.6
Thyroid	ML1	9.1
Thyroid	SW579	8.3
Thyroid	TT2609C02	8.7
Thyroid	TT	8.1
Upper aerodigestive tract	BHY	8.3
Upper aerodigestive tract	BICR16	7.6
Upper aerodigestive tract	BICR18	8.1
Upper aerodigestive tract	BICR22	8.9
Upper aerodigestive tract	BICR31	7.2
Upper aerodigestive tract	BICR56	9.3
Upper aerodigestive tract	BICR6	9.1
Upper aerodigestive tract	CAL27	9
Upper aerodigestive tract	CAL33	8.8
Upper aerodigestive tract	DETROIT562	8.1
Upper aerodigestive tract	FADU	9.6
Upper aerodigestive tract	HS840T	8.2
Upper aerodigestive tract	HSC2	8.8
Upper aerodigestive tract	HSC3	8.8
Upper aerodigestive tract	HSC4	9.6
Upper aerodigestive tract	PECAPJ15	9.2
Upper aerodigestive tract	PECAPJ34CLONEC12	8.7
Upper aerodigestive tract	PECAPJ41CLONED2	8.8
Upper aerodigestive tract	PECAPJ49	7.6
Upper aerodigestive tract	SCC15	8.7
Upper aerodigestive tract	SCC25	8.7
Upper aerodigestive tract	SCC4	8.8
Upper aerodigestive tract	SCC9	8.6
Upper aerodigestive tract	SNU1076	8.6
Upper aerodigestive tract	SNU1214	8.2
Upper aerodigestive tract	SNU46	8.4
Upper aerodigestive tract	SNU899	8.4
Upper aerodigestive tract	YD10B	8.7
Upper aerodigestive tract	YD38	8.8
Upper aerodigestive tract	YD8	9.4
Urinary tract	5637	8.3
Urinary tract	639V	9.3
Urinary tract	647V	9.4
Urinary tract	BC3C	8.7
Urinary tract	BFTC905	9.3
Urinary tract	CAL29	8.9
Urinary tract	HS172T	8.2
Urinary tract	HT1197	9
Urinary tract	HT1376	8.8
Urinary tract	J82	8.6
Urinary tract	JMSU1	9.2
Urinary tract	KMBC2	9
Urinary tract	KU1919	10.4
Urinary tract	RT11284	9.2
Urinary tract	RT112	8.8
Urinary tract	RT4	9.4
Urinary tract	SCABER	8.8
Urinary tract	SW1710	9.2
Urinary tract	SW780	9.2
Urinary tract	T24	8.7
Urinary tract	TCCSUP	8.6
Urinary tract	UMUC1	8.2
Urinary tract	UMUC3	8.6
Urinary tract	VMCUB1	9.3

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	9.8
Adrenal gland	10.8
Appendix	14.9
Bone marrow	16.3
Breast	16.7
Cerebral cortex	19
Cervix, uterine	19.2
Colon	9.1
Duodenum	9
Endometrium	25.1
Epididymis	35.9
Esophagus	13
Fallopian tube	14.8
Gallbladder	17.4
Heart muscle	5.8
Kidney	14.5
Liver	6.3
Lung	16.4
Lymph node	15.8
Ovary	17.7
Pancreas	2.5
Parathyroid gland	26.6
Placenta	22.7
Prostate	20.1
Rectum	11.3
Salivary gland	4.5
Seminal vesicle	15.3
Skeletal muscle	2.4
Skin	17.7
Small intestine	9.4
Smooth muscle	17.4
Spleen	17.9
Stomach	10.6
Testis	46
Thyroid gland	23.8
Tonsil	12.3
Urinary bladder	12.5

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
27430247	underexpression	Bladder Carcinoma	TIF1γ, which catalyzes the SUMOylation of SnoN, was downregulated in BC tissues.
25381221	underexpression	Clear Cell Renal Cell Carcinoma	In clinical ccRCC specimens, downregulation of TRIM33 was observed with the association of both pathologic stages and grades.
24954480	underexpression	Hepatocellular Carcinoma	Reduced expression of TIF1γ was detected in HCC, especially in advanced HCC tissues, compared to adjacent noncancerous tissues.
23676978	underexpression	Non-Small Cell Lung Carcinoma	Both mRNA and protein expression of TIF1γ were found significantly decreased in A549 and 95C compared with those in HBE (P<0.05).
22469842	underexpression	Pancreatic Neoplasm	TIF1γ expression is markedly down-regulated in human pancreatic tumors, and Pdx1-driven Tif1γ inactivation cooperates with the Kras(G12D) oncogene in the mouse pancreas to induce intraductal papillary mucinous neoplasms.
22046087	overexpression	Colorectal Carcinoma	Overexpression of TIF1γ was detected in 5/26 (19%) HP; however, it was seen in a significantly higher proportion of neoplasms, 15/25 (60%) TAs and 24/51 (47%) CRCs (P < 0.05).
19629168	underexpression	Pancreatic Neoplasm	Finally, we report that TIF1gamma expression is markedly down-regulated in human pancreatic tumors by quantitative RT-PCR and immunohistochemistry supporting the relevance of these findings to human malignancy.

Summary
Symbol	TRIM33
Name	tripartite motif containing 33
Aliases	TIF1GAMMA; FLJ11429; KIAA1113; TIFGAMMA; RFG7; TF1G; TIF1G; PTC7; transcriptional intermediary factor 1 gamm ......
Location	1p13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.34	2.31e-12	12.6	63.6	23.8	Neutral
BRCA	Breast invasive carcinoma	1075	0.474	1.93e-61	26.9	55.2	18	Neutral
CESC	Cervical and endocervical cancers	292	0.55	1.81e-24	11	63.4	25.7	Neutral
COAD	Colon adenocarcinoma	449	0.318	5.39e-12	27.2	68.6	4.2	Neutral
ESCA	Esophageal carcinoma	183	0.693	1.52e-27	33.9	45.9	20.2	Loss
GBM	Glioblastoma multiforme	147	0.28	0.000605	4.8	80.3	15	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.456	1.06e-27	25.7	67.5	6.8	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.294	6.06e-12	12	84.2	3.8	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.357	4.16e-10	12.5	85.8	1.7	Neutral
LAML	Acute Myeloid Leukemia	166	0.176	0.023	0.6	98.2	1.2	Neutral
LGG	Brain Lower Grade Glioma	513	0.53	1.92e-38	35.9	60.8	3.3	Loss
LIHC	Liver hepatocellular carcinoma	364	0.374	1.48e-13	22.3	63.5	14.3	Neutral
LUAD	Lung adenocarcinoma	512	0.474	5.08e-30	29.7	47.1	23.2	Neutral
LUSC	Lung squamous cell carcinoma	498	0.529	2.92e-37	43.8	44	12.2	Loss
OV	Ovarian serous cystadenocarcinoma	300	0.657	2.14e-38	16.3	53	30.7	Neutral
PAAD	Pancreatic adenocarcinoma	177	0.406	2.16e-08	23.2	70.1	6.8	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.589	1.66e-16	72.8	26.5	0.6	Loss
PRAD	Prostate adenocarcinoma	491	0.206	4.02e-06	6.7	91.4	1.8	Neutral
READ	Rectum adenocarcinoma	164	0.377	6.34e-07	32.9	60.4	6.7	Neutral
SARC	Sarcoma	255	0.386	1.82e-10	18.8	60	21.2	Neutral
SKCM	Skin Cutaneous Melanoma	367	0.537	9.31e-29	20.7	54.5	24.8	Neutral
STAD	Stomach adenocarcinoma	413	0.455	1.58e-22	21.1	67.3	11.6	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.286	0.000381	12	57.3	30.7	Neutral
THCA	Thyroid carcinoma	497	0.183	4.05e-05	0.8	98.4	0.8	Neutral
THYM	Thymoma	119	0.286	0.00162	5	90.8	4.2	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.277	5.99e-11	6.3	83.4	10.2	Neutral

Summary
Symbol	TRIM33
Name	tripartite motif containing 33
Aliases	TIF1GAMMA; FLJ11429; KIAA1113; TIFGAMMA; RFG7; TF1G; TIF1G; PTC7; transcriptional intermediary factor 1 gamm ......
Location	1p13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.215	7.82e-06	17	408	-0.236	6.35e-13	Decreased
BRCA	Breast invasive carcinoma	-0.213	2.36e-10	83	785	0.001	0.229	NS/NA
CESC	Cervical and endocervical cancers	-0.294	1.57e-07	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.194	0.000532	19	297	-0.013	0.732	NS/NA
ESCA	Esophageal carcinoma	-0.458	2.31e-11	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.197	0.115	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.26	9.46e-10	20	522	0.004	0.00937	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.051	0.346	24	319	0.007	0.00178	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.217	0.00016	23	275	0.011	0.000166	NS/NA
LAML	Acute Myeloid Leukemia	-0.088	0.253	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.422	0	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.18	0.000244	41	373	0.006	0.00754	NS/NA
LUAD	Lung adenocarcinoma	-0.362	3e-16	21	456	-0.121	4.81e-10	NS/NA
LUSC	Lung squamous cell carcinoma	-0.296	5.28e-09	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.65	0.0666	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.304	3.11e-05	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.461	3.97e-11	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.146	0.000717	35	498	0.008	1.34e-05	NS/NA
READ	Rectum adenocarcinoma	-0.38	0.000101	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.294	1.4e-06	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.382	0	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.307	1.72e-09	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.263	0.000924	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.052	0.223	50	509	0	0.453	NS/NA
THYM	Thymoma	-0.241	0.00757	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.212	4.15e-06	34	431	-0.001	0.463	NS/NA

Summary
Symbol	TRIM33
Name	tripartite motif containing 33
Aliases	TIF1GAMMA; FLJ11429; KIAA1113; TIFGAMMA; RFG7; TF1G; TIF1G; PTC7; transcriptional intermediary factor 1 gamm ......
Location	1p13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	3	High
Appendix	2	Medium
Bone marrow	3	High
Breast	2	Medium
Bronchus	2	Medium
Caudate	2	Medium
Cerebellum	3	High
Cerebral cortex	3	High
Cervix, uterine	2	Medium
Colon	2	Medium
Duodenum	2	Medium
Endometrium	3	High
Epididymis	2	Medium
Esophagus	2	Medium
Fallopian tube	2	Medium
Gallbladder	3	High
Heart muscle	1	Low
Hippocampus	3	High
Kidney	2	Medium
Liver	1	Low
Lung	2	Medium
Lymph node	2	Medium
Nasopharynx	2	Medium
Oral mucosa	2	Medium
Ovary	2	Medium
Pancreas	3	High
Parathyroid gland	2	Medium
Placenta	3	High
Prostate	2	Medium
Rectum	2	Medium
Salivary gland	2	Medium
Seminal vesicle	1	Low
Skeletal muscle	1	Low
Skin	3	High
Small intestine	2	Medium
Smooth muscle	1	Low
Soft tissue	2	Medium
Spleen	1	Low
Stomach	2	Medium
Testis	2	Medium
Thyroid gland	3	High
Tonsil	3	High
Urinary bladder	3	High
Vagina	2	Medium

Summary
Symbol	TRIM33
Name	tripartite motif containing 33
Aliases	TIF1GAMMA; FLJ11429; KIAA1113; TIFGAMMA; RFG7; TF1G; TIF1G; PTC7; transcriptional intermediary factor 1 gamm ......
Location	1p13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.0171	Significant	24476821
BRCA	Breast invasive carcinoma	521	0.0202	Significant	23000897
COAD	Colon adenocarcinoma	149	0.0262	Significant	22810696
GBM	Glioblastoma multiforme	157	0.0024	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	1.28e-06	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.46	NS	26536169
LGG	Brain Lower Grade Glioma	513	3.43e-36	Significant	26824661
LUAD	Lung adenocarcinoma	230	0.537	NS	25079552
LUSC	Lung squamous cell carcinoma	178	0.0178	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.000603	Significant	21720365
PRAD	Prostate adenocarcinoma	333	2.31e-05	Significant	26544944
READ	Rectum adenocarcinoma	67	0.141	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	6.71e-07	Significant	26091043
STAD	Stomach adenocarcinoma	277	0.00663	Significant	25079317
THCA	Thyroid carcinoma	391	0.697	NS	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.619	NS	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	0.872	0.512	NS
BRCA	Breast invasive carcinoma	1079	0.905	0.647	NS
CESC	Cervical and endocervical cancers	291	0.934	0.841	NS
COAD	Colon adenocarcinoma	439	0.593	0.0944	NS
ESCA	Esophageal carcinoma	184	0.837	0.593	NS
GBM	Glioblastoma multiforme	158	0.647	0.0868	NS
HNSC	Head and Neck squamous cell carcinoma	518	0.618	0.0163	Longer
KIRC	Kidney renal clear cell carcinoma	531	0.646	0.0473	Longer
KIRP	Kidney renal papillary cell carcinoma	287	1.793	0.168	NS
LAML	Acute Myeloid Leukemia	149	0.632	0.095	NS
LGG	Brain Lower Grade Glioma	511	1.47	0.17	NS
LIHC	Liver hepatocellular carcinoma	365	1.31	0.267	NS
LUAD	Lung adenocarcinoma	502	1.37	0.117	NS
LUSC	Lung squamous cell carcinoma	494	0.753	0.148	NS
OV	Ovarian serous cystadenocarcinoma	303	1.116	0.607	NS
PAAD	Pancreatic adenocarcinoma	177	1.363	0.258	NS
PCPG	Pheochromocytoma and Paraganglioma	179	1.853	0.609	NS
PRAD	Prostate adenocarcinoma	497	0.512	0.569	NS
READ	Rectum adenocarcinoma	159	0.539	0.288	NS
SARC	Sarcoma	259	2.257	0.00706	Shorter
SKCM	Skin Cutaneous Melanoma	459	0.971	0.875	NS
STAD	Stomach adenocarcinoma	388	0.813	0.371	NS
TGCT	Testicular Germ Cell Tumors	134	0.609	0.735	NS
THCA	Thyroid carcinoma	500	1.844	0.38	NS
THYM	Thymoma	119	0.271	0.232	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	1.86	0.0253	Shorter

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	-0.074	0.135	NS
BRCA	Breast invasive carcinoma	1071	-0.071	0.0196	Lower
CESC	Cervical and endocervical cancers	167	0.075	0.334	NS
COAD	Colon adenocarcinoma	445	-0.057	0.228	NS
ESCA	Esophageal carcinoma	162	0.003	0.966	NS
HNSC	Head and Neck squamous cell carcinoma	448	-0.088	0.0638	NS
KIRC	Kidney renal clear cell carcinoma	531	-0.055	0.21	NS
KIRP	Kidney renal papillary cell carcinoma	260	-0.054	0.387	NS
LIHC	Liver hepatocellular carcinoma	347	0.066	0.221	NS
LUAD	Lung adenocarcinoma	507	-0.022	0.618	NS
LUSC	Lung squamous cell carcinoma	497	-0.029	0.514	NS
OV	Ovarian serous cystadenocarcinoma	302	-0.067	0.246	NS
PAAD	Pancreatic adenocarcinoma	176	0.063	0.406	NS
READ	Rectum adenocarcinoma	156	0.037	0.65	NS
SKCM	Skin Cutaneous Melanoma	410	-0.02	0.689	NS
STAD	Stomach adenocarcinoma	392	0.004	0.942	NS
TGCT	Testicular Germ Cell Tumors	81	0.066	0.557	NS
THCA	Thyroid carcinoma	499	-0.077	0.0849	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.077	0.0852	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	0.021	0.728	NS
HNSC	Head and Neck squamous cell carcinoma	498	-0.028	0.53	NS
KIRC	Kidney renal clear cell carcinoma	525	-0.095	0.0297	Lower
LGG	Brain Lower Grade Glioma	514	-0.013	0.764	NS
LIHC	Liver hepatocellular carcinoma	366	-0.058	0.269	NS
OV	Ovarian serous cystadenocarcinoma	296	0.053	0.361	NS
PAAD	Pancreatic adenocarcinoma	176	-0.072	0.341	NS
STAD	Stomach adenocarcinoma	406	-0.043	0.389	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.21	9.68e-07	Higher

Summary
Symbol	TRIM33
Name	tripartite motif containing 33
Aliases	TIF1GAMMA; FLJ11429; KIAA1113; TIFGAMMA; RFG7; TF1G; TIF1G; PTC7; transcriptional intermediary factor 1 gamm ......
Location	1p13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	TRIM33
Name	tripartite motif containing 33
Aliases	TIF1GAMMA; FLJ11429; KIAA1113; TIFGAMMA; RFG7; TF1G; TIF1G; PTC7; transcriptional intermediary factor 1 gamm ......
Location	1p13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for TRIM33.

Summary
Symbol	TRIM33
Name	tripartite motif containing 33
Aliases	TIF1GAMMA; FLJ11429; KIAA1113; TIFGAMMA; RFG7; TF1G; TIF1G; PTC7; transcriptional intermediary factor 1 gamm ......
Location	1p13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
27430247	Bladder Carcinoma	downstream	SnoN	positive regulation	Overexpression of TIF1γ restored the ability of SnoN to suppress the TGF-β pathway.
25381221	Clear Cell Renal Cell Carcinoma	upstream	miR-629	negative regulation	The miR-629 inhibitor significantly suppressed TGFβ-induced Smad activation by upregulating TRIM33 expression and subsequently inhibited the association of Smad2/3 and Smad4.
22046087	Colorectal Carcinoma	partner	Smad4	negative correlation	Furthermore, there was a correlation between TIF1γ overexpression and Smad4 loss in CRC (Kendall tau rank correlation value = 0.35, P < 0.05).