Browse UBR7 in pancancer

Summary
SymbolUBR7
Nameubiquitin protein ligase E3 component n-recognin 7 (putative)
Aliases C14orf130; chromosome 14 open reading frame 130; N-recognin-7; Putative E3 ubiquitin-protein ligase UBR7
Location14q32.12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Domain, Function and Classification
> Gene Ontology
> KEGG and Reactome Pathway
> Domain, Function and Classification
 
Domain PF02207 Putative zinc finger in N-recognin (UBR box)
Function

E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.

Classification
Class Modification Substrate Product PubMed
DNA modification cofactor DNA methylation # # 21745816
> Gene Ontology
 
Biological Process -
Molecular Function GO:0016874 ligase activity
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolUBR7
Nameubiquitin protein ligase E3 component n-recognin 7 (putative)
Aliases C14orf130; chromosome 14 open reading frame 130; N-recognin-7; Putative E3 ubiquitin-protein ligase UBR7
Location14q32.12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Mutation landscape in primary tumor tissue from TCGA
> Mutation landscape in cancer cell line from CCLE
> All mutations from COSMIC database V81
> Variations from text mining
> The Cancer Genome Atlas (TCGA)
 
> Cancer Cell Line Encyclopedia (CCLE)
 
There is no record.
> Catalogue of Somatic Mutations in Cancer (COSMIC)
 
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COSMIC ID
CDS change
AA change
Mutation Type
Anatomical Site
COSM958930c.379A>Gp.N127DSubstitution - MissenseEndometrium
COSM4738967c.960+1G>Ap.?UnknownLarge_intestine
COSM5905972c.805C>Tp.L269FSubstitution - MissenseSkin
COSM699054c.162G>Ap.K54KSubstitution - coding silentLung
COSM2252223c.292C>Tp.R98CSubstitution - MissenseBreast
COSM3499056c.918C>Gp.P306PSubstitution - coding silentSkin
COSM958938c.1047G>Tp.Q349HSubstitution - MissenseEndometrium
COSM2252223c.292C>Tp.R98CSubstitution - MissenseSkin
COSM958931c.473G>Ap.C158YSubstitution - MissenseEndometrium
COSM1749023c.788C>Gp.S263CSubstitution - MissenseUrinary_tract
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> Text Mining based Variations
 
There is no record for UBR7.
Summary
SymbolUBR7
Nameubiquitin protein ligase E3 component n-recognin 7 (putative)
Aliases C14orf130; chromosome 14 open reading frame 130; N-recognin-7; Putative E3 ubiquitin-protein ligase UBR7
Location14q32.12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Post-translational modification (PTM)
> Post-translational modification (PTM)
 
 Filter By:
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Uniprot ID
Position
Amino Acid
Description
Upstream Enzyme
Amino Acid Sequence Variant
Q8N806354SPhosphoserine-None detected
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Summary
SymbolUBR7
Nameubiquitin protein ligase E3 component n-recognin 7 (putative)
Aliases C14orf130; chromosome 14 open reading frame 130; N-recognin-7; Putative E3 ubiquitin-protein ligase UBR7
Location14q32.12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Expression analysis in primary tumor tissue from TCGA
> Expression level in cancer cell line from CCLE
> Expression level in human normal tissue from HPA
> Text mining based expression change
> The Cancer Genome Atlas (TCGA)
 


  Differential expression analysis for cancers with more than 10 normal samples
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Cancer
Full Name
# N
# T
Median (N)
Median (T)
LogFC
Adj. P
Status
BLCABladder urothelial carcinoma194085.4525.363-0.0910.578NS
BRCABreast invasive carcinoma11211005.8686.1630.3074.63e-08NS
CESCCervical and endocervical cancers33065.5396.065NANANA
COADColon adenocarcinoma414595.7755.436-0.4122.77e-08NS
ESCAEsophageal carcinoma111855.5825.466-0.1140.582NS
GBMGlioblastoma multiforme51666.246.483NANANA
HNSCHead and Neck squamous cell carcinoma445225.3415.4410.1340.0757NS
KIRCKidney renal clear cell carcinoma725345.7695.9950.1170.0254NS
KIRPKidney renal papillary cell carcinoma322915.5785.7570.1240.142NS
LAMLAcute Myeloid Leukemia0173NA6.122NANANA
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> Cancer Cell Line Encyclopedia (CCLE)
 



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Tissue
Cell Line
Expression Level (Microarray)
Autonomic gangliaCHP12610.3
Autonomic gangliaCHP2129.7
Autonomic gangliaIMR3210.3
Autonomic gangliaKELLY9.8
Autonomic gangliaKPNRTBM110.3
Autonomic gangliaKPNSI9S9.2
Autonomic gangliaKPNYN10.3
Autonomic gangliaMHHNB118.3
Autonomic gangliaNB19.6
Autonomic gangliaNH69.9
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> The Human Protein Atlas (HPA)
 


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Tissue
Expression Level (TPM)
Adipose tissue7
Adrenal gland6.5
Appendix8.9
Bone marrow6.7
Breast11.3
Cerebral cortex19.5
Cervix, uterine12.8
Colon8.6
Duodenum6.1
Endometrium11.9
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> Text Mining based Expression
 
There is no record.
Summary
SymbolUBR7
Nameubiquitin protein ligase E3 component n-recognin 7 (putative)
Aliases C14orf130; chromosome 14 open reading frame 130; N-recognin-7; Putative E3 ubiquitin-protein ligase UBR7
Location14q32.12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Somatic copy number alteration in primary tomur tissue
> The Cancer Genome Atlas (TCGA)
 


  Correlation between expression and SCNA as well as percentage of patients in different status.
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Cancer
Full Name
# Sample
R
P
% Loss
% Neutral
% Gain
Status
BLCABladder urothelial carcinoma4040.6221.1e-4430.752.217.1Neutral
BRCABreast invasive carcinoma10750.5364.97e-813056.713.3Neutral
CESCCervical and endocervical cancers2920.72.25e-4416.466.117.5Neutral
COADColon adenocarcinoma4490.5576.25e-3833.459.57.1Loss
ESCAEsophageal carcinoma1830.6712.44e-2532.24126.8Neutral
GBMGlioblastoma multiforme1470.7014.37e-2333.361.25.4Neutral
HNSCHead and Neck squamous cell carcinoma5140.4744.32e-3013.655.331.1Neutral
KIRCKidney renal clear cell carcinoma5250.6114.25e-5542.554.53Loss
KIRPKidney renal papillary cell carcinoma2880.4582.28e-161781.91Neutral
LAMLAcute Myeloid Leukemia166-0.0220.783098.81.2Neutral
Showing 1 to 10 of 26 rows rows per page
Summary
SymbolUBR7
Nameubiquitin protein ligase E3 component n-recognin 7 (putative)
Aliases C14orf130; chromosome 14 open reading frame 130; N-recognin-7; Putative E3 ubiquitin-protein ligase UBR7
Location14q32.12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Methylation level in the promoter region of CR
> Methylation level in the promoter region of CR
 


  Correlation between expression and methylation as well as differential methylation analysis.
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Cancer
Full Name
R
P
# N
# T
Delta beta (T vs N)
P value (T vs N)
Status
BLCABladder urothelial carcinoma-0.2569.16e-0817408-0.2611.43e-07Decreased
BRCABreast invasive carcinoma-0.330837850.0013.23e-07NS/NA
CESCCervical and endocervical cancers-0.2537.26e-063306NANANS/NA
COADColon adenocarcinoma-0.2120.00015119297-0.0490.0249NS/NA
ESCAEsophageal carcinoma-0.1930.007249185NANANS/NA
GBMGlioblastoma multiforme-0.1660.186164NANANS/NA
HNSCHead and Neck squamous cell carcinoma-0.366020522-0.1391.89e-06NS/NA
KIRCKidney renal clear cell carcinoma-0.1750.00118243190.0022.3e-10NS/NA
KIRPKidney renal papillary cell carcinoma-0.1810.00174232750.0020.989NS/NA
LAMLAcute Myeloid Leukemia-0.0090.9040170NANANS/NA
Showing 1 to 10 of 26 rows rows per page
Summary
SymbolUBR7
Nameubiquitin protein ligase E3 component n-recognin 7 (putative)
Aliases C14orf130; chromosome 14 open reading frame 130; N-recognin-7; Putative E3 ubiquitin-protein ligase UBR7
Location14q32.12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Primary tumor tissue from TCGA
> Normal tumor tissue from HPA
>The Cancer Genome Atlas (TCGA)
 
There is no record.
> The Human Protein Atlas (HPA)
 


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Tissue
Level
Level Name
Adrenal gland2Medium
Appendix3High
Bone marrow3High
Breast2Medium
Bronchus3High
Caudate2Medium
Cerebellum2Medium
Cerebral cortex2Medium
Cervix, uterine2Medium
Colon2Medium
Showing 1 to 10 of 44 rows rows per page
Summary
SymbolUBR7
Nameubiquitin protein ligase E3 component n-recognin 7 (putative)
Aliases C14orf130; chromosome 14 open reading frame 130; N-recognin-7; Putative E3 ubiquitin-protein ligase UBR7
Location14q32.12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Association between expresson and subtype
> Overall survival analysis based on expression
> Association between expresson and stage
> Association between expresson and grade
> Subtype
 


  Association between expresson and subtype.
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Cancer
Full Name
# Patients
P Value (Kruskal-Wallis)
Association
Source
BLCABladder urothelial carcinoma1280.0103Significant24476821
BRCABreast invasive carcinoma5219.67e-15Significant23000897
COADColon adenocarcinoma1493.07e-05Significant22810696
GBMGlioblastoma multiforme1572.34e-05Significant26824661
HNSCHead and Neck squamous cell carcinoma2790.00866Significant25631445
KIRPKidney renal papillary cell carcinoma1610.973NS26536169
LGGBrain Lower Grade Glioma5136.57e-07Significant26824661
LUADLung adenocarcinoma2300.255NS25079552
LUSCLung squamous cell carcinoma1780.00219Significant22960745
OVOvarian serous cystadenocarcinoma2870.188NS21720365
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> Overall survival
 

  Overall survival analysis based on expression.
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Cancer
Full Name
# Patients
Hazard Ratio
P Value (Log Rank Test)
Association
BLCABladder urothelial carcinoma405 1.1110.622NS
BRCABreast invasive carcinoma1079 1.120.606NS
CESCCervical and endocervical cancers291 0.6750.285NS
COADColon adenocarcinoma439 0.6120.0821NS
ESCAEsophageal carcinoma184 0.9710.933NS
GBMGlioblastoma multiforme158 0.8450.504NS
HNSCHead and Neck squamous cell carcinoma518 1.1490.476NS
KIRCKidney renal clear cell carcinoma531 0.4430.000118Longer
KIRPKidney renal papillary cell carcinoma287 0.3550.0156Longer
LAMLAcute Myeloid Leukemia149 0.9650.907NS
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> Stage
 

  Association between expresson and stage.
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Cancer
Full Name
# Patients
R Value (Spearman)
P Value (Spearman)
Association
BLCABladder urothelial carcinoma406 -0.0010.98NS
BRCABreast invasive carcinoma1071 0.0050.859NS
CESCCervical and endocervical cancers167 0.0260.737NS
COADColon adenocarcinoma445 -0.1580.00083Lower
ESCAEsophageal carcinoma162 -0.0460.563NS
HNSCHead and Neck squamous cell carcinoma448 -0.0080.87NS
KIRCKidney renal clear cell carcinoma531 -0.1520.000435Lower
KIRPKidney renal papillary cell carcinoma260 0.0040.95NS
LIHCLiver hepatocellular carcinoma347 0.1050.0517NS
LUADLung adenocarcinoma507 0.0050.917NS
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> Grade
 

  Association between expresson and grade.
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Cancer
Full Name
# Patients
R Value (Spearman)
P Value (Spearman)
Association
CESCCervical and endocervical cancers272 -0.1150.0588NS
HNSCHead and Neck squamous cell carcinoma498 0.140.0017Higher
KIRCKidney renal clear cell carcinoma525 -0.2184.83e-07Lower
LGGBrain Lower Grade Glioma514 0.0030.947NS
LIHCLiver hepatocellular carcinoma366 -0.0870.0977NS
OVOvarian serous cystadenocarcinoma296 -0.0290.624NS
PAADPancreatic adenocarcinoma176 -0.1410.0624NS
STADStomach adenocarcinoma406 -0.0510.303NS
UCECUterine Corpus Endometrial Carcinoma534 0.1974.32e-06Higher
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Summary
SymbolUBR7
Nameubiquitin protein ligase E3 component n-recognin 7 (putative)
Aliases C14orf130; chromosome 14 open reading frame 130; N-recognin-7; Putative E3 ubiquitin-protein ligase UBR7
Location14q32.12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Targets inferred by reverse engineering method
> Targets identified by ChIP-seq data
> Targets inferred by reverse engineering method
 
> Targets identified by ChIP-seq data
 
Summary
SymbolUBR7
Nameubiquitin protein ligase E3 component n-recognin 7 (putative)
Aliases C14orf130; chromosome 14 open reading frame 130; N-recognin-7; Putative E3 ubiquitin-protein ligase UBR7
Location14q32.12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Drugs from DrugBank database
> Drugs from DrugBank database
 
There is no record for UBR7.
Summary
SymbolUBR7
Nameubiquitin protein ligase E3 component n-recognin 7 (putative)
Aliases C14orf130; chromosome 14 open reading frame 130; N-recognin-7; Putative E3 ubiquitin-protein ligase UBR7
Location14q32.12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Protein-Protein Interaction Network
> miRNA Regulatory Relationship
> Interactions from Text Mining
> Protein-Protein Interaction Network
 
> miRNA Regulatory Relationship
 
> Interactions from Text Mining
 
There is no record for UBR7.