This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are
presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.
"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.
Num | microRNA | Gene | miRNA log2FC | miRNA pvalue | Gene log2FC | Gene pvalue | Interaction | Correlation beta | Correlation P-value | PMID | Reported in cancer studies |
---|---|---|---|---|---|---|---|---|---|---|---|
1 | hsa-miR-454-3p | ACSL1 | 1.4 | 0.00366 | -0.26 | 0.66804 | MirTarget | -0.21 | 0.00407 | NA | |
2 | hsa-miR-454-3p | ACSL4 | 1.4 | 0.00366 | -0.89 | 0.13062 | MirTarget; miRNATAP | -0.14 | 0.04315 | NA | |
3 | hsa-miR-454-3p | ACVR1 | 1.4 | 0.00366 | -0.76 | 0.04389 | MirTarget; miRNATAP | -0.12 | 0.00599 | NA | |
4 | hsa-miR-454-3p | AKAP11 | 1.4 | 0.00366 | -0.61 | 0.12508 | miRNATAP | -0.12 | 0.00898 | NA | |
5 | hsa-miR-454-3p | AMPD3 | 1.4 | 0.00366 | 1.34 | 0.01947 | MirTarget; miRNATAP | -0.28 | 3.0E-5 | NA | |
6 | hsa-miR-454-3p | ANKRD12 | 1.4 | 0.00366 | -0.49 | 0.18892 | MirTarget; miRNATAP | -0.11 | 0.01667 | NA | |
7 | hsa-miR-106a-5p | APCDD1 | 3.99 | 0 | -2.17 | 0.00459 | MirTarget | -0.15 | 0.00407 | NA | |
8 | hsa-miR-130b-3p | APCDD1 | 3.92 | 0 | -2.17 | 0.00459 | MirTarget | -0.18 | 0.0162 | NA | |
9 | hsa-miR-20b-5p | APCDD1 | 4.57 | 5.0E-5 | -2.17 | 0.00459 | MirTarget | -0.1 | 0.00797 | NA | |
10 | hsa-miR-330-5p | APCDD1 | 2.25 | 0.00028 | -2.17 | 0.00459 | miRanda | -0.14 | 0.04065 | NA | |
11 | hsa-miR-93-5p | APCDD1 | 2.66 | 0 | -2.17 | 0.00459 | MirTarget | -0.23 | 0.01143 | NA | |
12 | hsa-miR-454-3p | AR | 1.4 | 0.00366 | -4.57 | 0.00169 | mirMAP; miRNATAP | -0.47 | 0.00625 | NA | |
13 | hsa-miR-454-3p | ARAP2 | 1.4 | 0.00366 | 1.71 | 0.00222 | MirTarget | -0.2 | 0.00207 | NA | |
14 | hsa-miR-454-3p | ARHGAP21 | 1.4 | 0.00366 | -0.14 | 0.76187 | MirTarget; miRNATAP | -0.14 | 0.01042 | NA | |
15 | hsa-miR-454-3p | ARHGEF12 | 1.4 | 0.00366 | -0.4 | 0.28538 | MirTarget; miRNATAP | -0.16 | 0.0003 | NA | |
16 | hsa-miR-454-3p | ASPA | 1.4 | 0.00366 | -5.53 | 0 | mirMAP | -0.32 | 0.02559 | NA | |
17 | hsa-miR-454-3p | ASXL2 | 1.4 | 0.00366 | 0.95 | 0.22717 | MirTarget; miRNATAP | -0.2 | 0.03105 | NA | |
18 | hsa-miR-454-3p | ATP6V1B2 | 1.4 | 0.00366 | 0.23 | 0.47152 | MirTarget; miRNATAP | -0.1 | 0.00585 | NA | |
19 | hsa-miR-454-3p | ATXN1 | 1.4 | 0.00366 | -1.43 | 0.00387 | miRNATAP | -0.17 | 0.00303 | NA | |
20 | hsa-miR-454-3p | BBX | 1.4 | 0.00366 | -0.18 | 0.63612 | MirTarget; miRNATAP | -0.1 | 0.02182 | NA | |
21 | hsa-miR-454-3p | BCL9L | 1.4 | 0.00366 | -0.12 | 0.78985 | mirMAP | -0.14 | 0.00577 | NA | |
22 | hsa-miR-454-3p | BHLHE40 | 1.4 | 0.00366 | 0.96 | 0.11887 | miRNAWalker2 validate | -0.24 | 0.00086 | NA | |
23 | hsa-miR-454-3p | BRWD3 | 1.4 | 0.00366 | 2.22 | 0.00115 | MirTarget; miRNATAP | -0.2 | 0.01287 | NA | |
24 | hsa-miR-454-3p | BTBD10 | 1.4 | 0.00366 | 0.43 | 0.25557 | MirTarget | -0.18 | 3.0E-5 | NA | |
25 | hsa-miR-454-3p | BTG1 | 1.4 | 0.00366 | -0.9 | 0.02841 | miRNATAP | -0.11 | 0.02771 | NA | |
26 | hsa-miR-454-3p | C15orf52 | 1.4 | 0.00366 | -1.2 | 0.18499 | mirMAP | -0.36 | 0.00077 | NA | |
27 | hsa-miR-454-3p | C1S | 1.4 | 0.00366 | -2.07 | 0.01886 | MirTarget | -0.25 | 0.01612 | NA | |
28 | hsa-miR-454-3p | CD109 | 1.4 | 0.00366 | -0.13 | 0.90668 | mirMAP | -0.3 | 0.02391 | NA | |
29 | hsa-miR-454-3p | CD69 | 1.4 | 0.00366 | -0.72 | 0.42333 | miRNATAP | -0.25 | 0.01834 | NA | |
30 | hsa-miR-454-3p | CDH11 | 1.4 | 0.00366 | -2.72 | 0.00843 | mirMAP | -0.48 | 7.0E-5 | NA | |
31 | hsa-miR-454-3p | CHD9 | 1.4 | 0.00366 | -0.3 | 0.4758 | miRNATAP | -0.17 | 0.00054 | NA | |
32 | hsa-miR-454-3p | CLIP1 | 1.4 | 0.00366 | 0.26 | 0.56626 | MirTarget; miRNATAP | -0.21 | 7.0E-5 | NA | |
33 | hsa-miR-454-3p | CPEB2 | 1.4 | 0.00366 | -0.48 | 0.40022 | miRNATAP | -0.16 | 0.01428 | NA | |
34 | hsa-miR-454-3p | CPEB4 | 1.4 | 0.00366 | -0.65 | 0.23946 | miRNATAP | -0.16 | 0.01341 | NA | |
35 | hsa-miR-454-3p | CRISPLD1 | 1.4 | 0.00366 | -3 | 0.03284 | MirTarget | -0.4 | 0.01665 | NA | |
36 | hsa-miR-454-3p | CSF1 | 1.4 | 0.00366 | -1.1 | 0.12732 | MirTarget; miRNATAP | -0.2 | 0.02018 | NA | |
37 | hsa-miR-454-3p | CTSK | 1.4 | 0.00366 | -3.32 | 1.0E-5 | MirTarget | -0.47 | 0 | NA | |
38 | hsa-miR-454-3p | CYLD | 1.4 | 0.00366 | -0.05 | 0.90145 | miRNATAP | -0.12 | 0.0045 | 25824771 | MiR 454 prompts cell proliferation of human colorectal cancer cells by repressing CYLD expression; Bioinformatics analysis further revealed cylindromatosis CYLD a putative tumor suppressor as a potential target of miR-454; Data from luciferase reporter assays showed that miR-454 directly binds to the 3'-untranslated region 3'-UTR of CYLD mRNA and repressed expression at both transcriptional and translational levels; In sum our data provide compelling evidence that miR-454 functions as an onco-miRNA playing a crucial role in the promoting cell proliferation in CRC and its oncogenic effect is mediated chiefly through direct suppression of CYLD expression |
39 | hsa-miR-454-3p | CYP4F3 | 1.4 | 0.00366 | 5.4 | 0.001 | mirMAP | -0.39 | 0.04343 | NA | |
40 | hsa-miR-454-3p | DAAM1 | 1.4 | 0.00366 | 0.28 | 0.67526 | MirTarget; miRNATAP | -0.24 | 0.00186 | NA | |
41 | hsa-miR-454-3p | DLC1 | 1.4 | 0.00366 | -3.66 | 0 | miRNATAP | -0.3 | 0.00062 | NA | |
42 | hsa-miR-454-3p | DNM3 | 1.4 | 0.00366 | -2.57 | 0.00056 | mirMAP | -0.27 | 0.00193 | NA | |
43 | hsa-miR-454-3p | DYRK2 | 1.4 | 0.00366 | 0.06 | 0.87911 | mirMAP | -0.11 | 0.02274 | NA | |
44 | hsa-miR-454-3p | EEA1 | 1.4 | 0.00366 | -0.24 | 0.59857 | mirMAP | -0.23 | 2.0E-5 | NA | |
45 | hsa-miR-454-3p | ELK3 | 1.4 | 0.00366 | -0.79 | 0.2934 | MirTarget; miRNATAP | -0.42 | 0 | NA | |
46 | hsa-miR-454-3p | ENAH | 1.4 | 0.00366 | -0.27 | 0.60264 | miRNATAP | -0.13 | 0.03879 | NA | |
47 | hsa-miR-454-3p | ENDOD1 | 1.4 | 0.00366 | -1.15 | 0.01857 | MirTarget | -0.23 | 4.0E-5 | NA | |
48 | hsa-miR-454-3p | ESR1 | 1.4 | 0.00366 | -4.87 | 9.0E-5 | miRNATAP | -0.52 | 0.00045 | NA | |
49 | hsa-miR-454-3p | EVI5 | 1.4 | 0.00366 | -0.95 | 0.00393 | mirMAP | -0.1 | 0.00889 | NA | |
50 | hsa-miR-454-3p | FAM155A | 1.4 | 0.00366 | -3.09 | 0.00443 | MirTarget | -0.36 | 0.00573 | NA | |
51 | hsa-miR-454-3p | FAM179B | 1.4 | 0.00366 | -0.56 | 0.15244 | miRNATAP | -0.12 | 0.0124 | NA | |
52 | hsa-miR-454-3p | FAM46B | 1.4 | 0.00366 | 0.42 | 0.68311 | MirTarget; miRNATAP | -0.29 | 0.01569 | NA | |
53 | hsa-miR-454-3p | FIBIN | 1.4 | 0.00366 | -3.85 | 0.00528 | MirTarget | -0.66 | 4.0E-5 | NA | |
54 | hsa-miR-454-3p | FLNC | 1.4 | 0.00366 | -5.77 | 0 | miRNAWalker2 validate | -0.44 | 0.00361 | NA | |
55 | hsa-miR-454-3p | FMN1 | 1.4 | 0.00366 | 1.87 | 0.076 | mirMAP | -0.29 | 0.02163 | NA | |
56 | hsa-miR-454-3p | FOSL1 | 1.4 | 0.00366 | 2.1 | 0.0498 | MirTarget | -0.34 | 0.00737 | NA | |
57 | hsa-miR-454-3p | FRMD6 | 1.4 | 0.00366 | -1.61 | 0.08207 | MirTarget | -0.41 | 0.00018 | NA | |
58 | hsa-miR-454-3p | FRZB | 1.4 | 0.00366 | -4.07 | 5.0E-5 | MirTarget | -0.25 | 0.0365 | NA | |
59 | hsa-miR-454-3p | FZD6 | 1.4 | 0.00366 | 1.58 | 0.00919 | MirTarget | -0.15 | 0.04098 | NA | |
60 | hsa-miR-454-3p | G0S2 | 1.4 | 0.00366 | 0.4 | 0.71817 | MirTarget | -0.33 | 0.01043 | NA | |
61 | hsa-miR-454-3p | GADD45A | 1.4 | 0.00366 | -0.57 | 0.35686 | MirTarget; miRNATAP | -0.31 | 2.0E-5 | NA | |
62 | hsa-miR-454-3p | GBP4 | 1.4 | 0.00366 | 0.55 | 0.60015 | mirMAP | -0.28 | 0.02105 | NA | |
63 | hsa-miR-454-3p | GCLM | 1.4 | 0.00366 | 1.75 | 0.00401 | mirMAP | -0.17 | 0.01881 | NA | |
64 | hsa-miR-454-3p | GFOD1 | 1.4 | 0.00366 | 0.92 | 0.20897 | mirMAP | -0.19 | 0.02487 | NA | |
65 | hsa-miR-454-3p | GJA1 | 1.4 | 0.00366 | -1.39 | 0.17815 | MirTarget; miRNATAP | -0.29 | 0.01745 | NA | |
66 | hsa-miR-454-3p | GPR157 | 1.4 | 0.00366 | 2.04 | 0.0467 | mirMAP | -0.28 | 0.02172 | NA | |
67 | hsa-miR-454-3p | GPRC5A | 1.4 | 0.00366 | 1.52 | 0.16803 | mirMAP | -0.28 | 0.03169 | NA | |
68 | hsa-miR-454-3p | HECW2 | 1.4 | 0.00366 | -0.59 | 0.4122 | MirTarget | -0.3 | 0.00041 | NA | |
69 | hsa-miR-454-3p | HEG1 | 1.4 | 0.00366 | -1.11 | 0.15703 | miRNATAP | -0.38 | 3.0E-5 | NA | |
70 | hsa-miR-454-3p | HERC3 | 1.4 | 0.00366 | -0.31 | 0.56561 | MirTarget | -0.17 | 0.00587 | NA | |
71 | hsa-miR-454-3p | HES2 | 1.4 | 0.00366 | 6.53 | 1.0E-5 | mirMAP | -0.46 | 0.00885 | NA | |
72 | hsa-miR-454-3p | HIPK3 | 1.4 | 0.00366 | -0.3 | 0.74415 | MirTarget | -0.27 | 0.01549 | NA | |
73 | hsa-miR-454-3p | HIVEP2 | 1.4 | 0.00366 | 0.14 | 0.72176 | miRNATAP | -0.14 | 0.00237 | NA | |
74 | hsa-miR-454-3p | HRH1 | 1.4 | 0.00366 | -0.68 | 0.33264 | mirMAP | -0.25 | 0.00253 | NA | |
75 | hsa-miR-454-3p | IGF1 | 1.4 | 0.00366 | -4.48 | 0.00149 | MirTarget | -0.4 | 0.01817 | NA | |
76 | hsa-miR-454-3p | IL1RAP | 1.4 | 0.00366 | 1.81 | 0.02672 | MirTarget | -0.21 | 0.02802 | NA | |
77 | hsa-miR-454-3p | ITGA2 | 1.4 | 0.00366 | 2.49 | 0.01604 | mirMAP | -0.27 | 0.02766 | NA | |
78 | hsa-miR-454-3p | ITGA8 | 1.4 | 0.00366 | -4.42 | 0.00157 | mirMAP | -0.58 | 0.00047 | NA | |
79 | hsa-miR-454-3p | ITPR1 | 1.4 | 0.00366 | -3.7 | 0 | MirTarget; miRNATAP | -0.37 | 0 | NA | |
80 | hsa-miR-454-3p | JAM2 | 1.4 | 0.00366 | -5.56 | 0 | miRNATAP | -0.38 | 0.00044 | NA | |
81 | hsa-miR-454-3p | KCTD10 | 1.4 | 0.00366 | -1.32 | 0 | MirTarget | -0.13 | 4.0E-5 | NA | |
82 | hsa-miR-454-3p | KIAA1462 | 1.4 | 0.00366 | -4.22 | 0 | MirTarget | -0.23 | 0.00673 | NA | |
83 | hsa-miR-454-3p | KLF3 | 1.4 | 0.00366 | 0.06 | 0.86707 | miRNATAP | -0.13 | 0.00241 | NA | |
84 | hsa-miR-454-3p | KLF7 | 1.4 | 0.00366 | 0.14 | 0.86538 | MirTarget; miRNATAP | -0.23 | 0.02034 | NA | |
85 | hsa-miR-454-3p | KLHL20 | 1.4 | 0.00366 | -0.29 | 0.43362 | MirTarget; miRNATAP | -0.16 | 0.00028 | NA | |
86 | hsa-miR-454-3p | LDLR | 1.4 | 0.00366 | 0.07 | 0.90897 | miRNATAP | -0.18 | 0.01661 | NA | |
87 | hsa-miR-454-3p | LIPA | 1.4 | 0.00366 | -0.18 | 0.71748 | MirTarget | -0.12 | 0.04269 | NA | |
88 | hsa-miR-454-3p | LNPEP | 1.4 | 0.00366 | 1.08 | 0.04117 | MirTarget; miRNATAP | -0.13 | 0.03362 | NA | |
89 | hsa-miR-454-3p | LPP | 1.4 | 0.00366 | -1.15 | 0.02938 | mirMAP | -0.19 | 0.00183 | NA | |
90 | hsa-miR-454-3p | LRCH2 | 1.4 | 0.00366 | -5.17 | 0 | MirTarget; miRNATAP | -0.44 | 0.00017 | NA | |
91 | hsa-miR-454-3p | MAFB | 1.4 | 0.00366 | 0.68 | 0.42819 | miRNATAP | -0.26 | 0.00981 | NA | |
92 | hsa-miR-454-3p | MAP4 | 1.4 | 0.00366 | -0.73 | 0.032 | MirTarget | -0.1 | 0.01022 | NA | |
93 | hsa-miR-454-3p | MAPK10 | 1.4 | 0.00366 | -4.03 | 0.00046 | miRNATAP | -0.57 | 2.0E-5 | NA | |
94 | hsa-miR-454-3p | MBNL3 | 1.4 | 0.00366 | 1.26 | 0.12966 | MirTarget; mirMAP; miRNATAP | -0.21 | 0.02942 | NA | |
95 | hsa-miR-454-3p | MCC | 1.4 | 0.00366 | -0.68 | 0.46777 | MirTarget | -0.32 | 0.00382 | NA | |
96 | hsa-miR-454-3p | MDFIC | 1.4 | 0.00366 | -1.36 | 0.0449 | MirTarget; miRNATAP | -0.2 | 0.01345 | NA | |
97 | hsa-miR-454-3p | MED12 | 1.4 | 0.00366 | 0.15 | 0.67052 | miRNAWalker2 validate | -0.12 | 0.00404 | NA | |
98 | hsa-miR-454-3p | MEOX2 | 1.4 | 0.00366 | -6.19 | 0 | MirTarget; miRNATAP | -0.34 | 0.01532 | NA | |
99 | hsa-miR-454-3p | MID1IP1 | 1.4 | 0.00366 | 0.66 | 0.10505 | miRNATAP | -0.12 | 0.01561 | NA | |
100 | hsa-miR-454-3p | MMP16 | 1.4 | 0.00366 | -2.72 | 0.00811 | mirMAP | -0.32 | 0.00815 | NA | |
101 | hsa-miR-454-3p | MPPED2 | 1.4 | 0.00366 | -2.45 | 0.15823 | MirTarget | -0.6 | 0.00333 | NA | |
102 | hsa-miR-454-3p | MUC20 | 1.4 | 0.00366 | 1.73 | 0.20488 | mirMAP | -0.34 | 0.03626 | NA | |
103 | hsa-miR-454-3p | NAP1L3 | 1.4 | 0.00366 | -5.22 | 0 | MirTarget | -0.5 | 1.0E-5 | NA | |
104 | hsa-miR-454-3p | NAV1 | 1.4 | 0.00366 | 0.37 | 0.59295 | miRNATAP | -0.31 | 0.00012 | NA | |
105 | hsa-miR-454-3p | NFIA | 1.4 | 0.00366 | -0.82 | 0.18121 | miRNATAP | -0.22 | 0.00242 | NA | |
106 | hsa-miR-454-3p | NFIC | 1.4 | 0.00366 | -0.58 | 0.41726 | miRNATAP | -0.17 | 0.04248 | NA | |
107 | hsa-miR-454-3p | NHLH2 | 1.4 | 0.00366 | 2.73 | 0.13264 | MirTarget; miRNATAP | -0.55 | 0.01024 | NA | |
108 | hsa-miR-454-3p | NOX4 | 1.4 | 0.00366 | -2.45 | 0.00259 | MirTarget | -0.25 | 0.00813 | NA | |
109 | hsa-miR-454-3p | NPAT | 1.4 | 0.00366 | 0.09 | 0.81886 | MirTarget; miRNATAP | -0.12 | 0.00874 | NA | |
110 | hsa-miR-454-3p | PCDHB4 | 1.4 | 0.00366 | -4.44 | 0 | MirTarget | -0.41 | 0.00019 | NA | |
111 | hsa-miR-454-3p | PDCD1LG2 | 1.4 | 0.00366 | -0.81 | 0.39863 | MirTarget | -0.35 | 0.00234 | NA | |
112 | hsa-miR-454-3p | PDGFRA | 1.4 | 0.00366 | -4.32 | 1.0E-5 | MirTarget; miRNATAP | -0.46 | 8.0E-5 | NA | |
113 | hsa-miR-454-3p | PGM2L1 | 1.4 | 0.00366 | -1.68 | 0.03208 | MirTarget; miRNATAP | -0.2 | 0.02728 | NA | |
114 | hsa-miR-454-3p | PGR | 1.4 | 0.00366 | -7.62 | 0 | mirMAP | -0.66 | 0.00018 | NA | |
115 | hsa-miR-454-3p | PLCB1 | 1.4 | 0.00366 | -1.81 | 0.07239 | miRNATAP | -0.3 | 0.01148 | NA | |
116 | hsa-miR-454-3p | PMEPA1 | 1.4 | 0.00366 | -0.44 | 0.56222 | MirTarget; miRNATAP | -0.22 | 0.0153 | NA | |
117 | hsa-miR-454-3p | POLR2A | 1.4 | 0.00366 | 0.02 | 0.96289 | miRNAWalker2 validate | -0.12 | 0.00447 | NA | |
118 | hsa-miR-454-3p | PPP1R12B | 1.4 | 0.00366 | -4.65 | 0 | mirMAP | -0.37 | 1.0E-5 | NA | |
119 | hsa-miR-454-3p | PRKG1 | 1.4 | 0.00366 | -4.14 | 0.00035 | miRNATAP | -0.54 | 9.0E-5 | NA | |
120 | hsa-miR-454-3p | PSD | 1.4 | 0.00366 | -5.74 | 0 | miRNATAP | -0.27 | 0.00711 | NA | |
121 | hsa-miR-454-3p | PTGFRN | 1.4 | 0.00366 | 0.01 | 0.98805 | miRNATAP | -0.13 | 0.01288 | NA | |
122 | hsa-miR-454-3p | PXK | 1.4 | 0.00366 | -1.19 | 0.05304 | MirTarget | -0.17 | 0.02128 | NA | |
123 | hsa-miR-454-3p | RALGPS2 | 1.4 | 0.00366 | 1.31 | 0.01845 | MirTarget | -0.2 | 0.00201 | NA | |
124 | hsa-miR-454-3p | RAP2C | 1.4 | 0.00366 | -0.96 | 0.01088 | miRNAWalker2 validate; MirTarget; miRNATAP | -0.18 | 3.0E-5 | NA | |
125 | hsa-miR-454-3p | RAPGEF4 | 1.4 | 0.00366 | -2.71 | 0.0001 | MirTarget; miRNATAP | -0.18 | 0.03366 | NA | |
126 | hsa-miR-454-3p | RARB | 1.4 | 0.00366 | -1.23 | 0.24963 | miRNATAP | -0.51 | 5.0E-5 | NA | |
127 | hsa-miR-454-3p | RASL12 | 1.4 | 0.00366 | -5.24 | 0 | MirTarget | -0.31 | 0.00122 | NA | |
128 | hsa-miR-454-3p | RASSF6 | 1.4 | 0.00366 | 4.23 | 0.00014 | mirMAP | -0.27 | 0.03868 | NA | |
129 | hsa-miR-454-3p | RC3H2 | 1.4 | 0.00366 | 0.73 | 0.09436 | mirMAP | -0.1 | 0.0489 | NA | |
130 | hsa-miR-454-3p | RNF11 | 1.4 | 0.00366 | -0.85 | 0.01247 | miRNATAP | -0.14 | 0.00051 | NA | |
131 | hsa-miR-454-3p | ROBO1 | 1.4 | 0.00366 | 0.25 | 0.74813 | miRNATAP | -0.25 | 0.00697 | NA | |
132 | hsa-miR-454-3p | ROBO2 | 1.4 | 0.00366 | -1.5 | 0.3479 | miRNATAP | -0.5 | 0.00798 | NA | |
133 | hsa-miR-454-3p | RUNX1T1 | 1.4 | 0.00366 | -4.61 | 4.0E-5 | miRNATAP | -0.54 | 5.0E-5 | NA | |
134 | hsa-miR-454-3p | RUNX2 | 1.4 | 0.00366 | 0.93 | 0.19285 | miRNATAP | -0.3 | 0.00038 | NA | |
135 | hsa-miR-454-3p | S1PR1 | 1.4 | 0.00366 | -4.01 | 0 | MirTarget; miRNATAP | -0.28 | 0.00027 | NA | |
136 | hsa-miR-454-3p | SAMHD1 | 1.4 | 0.00366 | 1.22 | 0.08415 | mirMAP | -0.17 | 0.04153 | NA | |
137 | hsa-miR-454-3p | SASH1 | 1.4 | 0.00366 | -1.01 | 0.06247 | MirTarget; miRNATAP | -0.15 | 0.01615 | NA | |
138 | hsa-miR-454-3p | SBF2 | 1.4 | 0.00366 | -0.78 | 0.06145 | MirTarget | -0.14 | 0.00328 | NA | |
139 | hsa-miR-454-3p | SCN3A | 1.4 | 0.00366 | -3.02 | 0.0067 | MirTarget | -0.3 | 0.0227 | NA | |
140 | hsa-miR-454-3p | SESN3 | 1.4 | 0.00366 | -0.38 | 0.69604 | mirMAP | -0.3 | 0.00906 | NA | |
141 | hsa-miR-454-3p | SETD7 | 1.4 | 0.00366 | -1.43 | 0.00158 | miRNATAP | -0.11 | 0.0386 | NA | |
142 | hsa-miR-454-3p | SH3D19 | 1.4 | 0.00366 | -1.17 | 0.00804 | MirTarget; miRNATAP | -0.22 | 2.0E-5 | NA | |
143 | hsa-miR-454-3p | SHROOM4 | 1.4 | 0.00366 | -2.05 | 0.01488 | mirMAP | -0.29 | 0.00335 | NA | |
144 | hsa-miR-454-3p | SIK3 | 1.4 | 0.00366 | -0.94 | 0.00631 | miRNAWalker2 validate | -0.16 | 0.0001 | NA | |
145 | hsa-miR-454-3p | SLC24A3 | 1.4 | 0.00366 | -4.25 | 0.00045 | MirTarget; miRNATAP | -0.46 | 0.00125 | NA | |
146 | hsa-miR-454-3p | SLC35D1 | 1.4 | 0.00366 | 0.16 | 0.71932 | MirTarget | -0.17 | 0.00137 | NA | |
147 | hsa-miR-454-3p | SLC8A1 | 1.4 | 0.00366 | -4.53 | 0 | MirTarget | -0.35 | 0.00027 | NA | |
148 | hsa-miR-454-3p | SLIT3 | 1.4 | 0.00366 | -4.87 | 1.0E-5 | mirMAP | -0.38 | 0.00345 | NA | |
149 | hsa-miR-454-3p | SLMAP | 1.4 | 0.00366 | -1.88 | 0 | MirTarget | -0.19 | 1.0E-5 | NA | |
150 | hsa-miR-454-3p | SMOC2 | 1.4 | 0.00366 | -6.42 | 0 | miRNATAP | -0.33 | 0.00948 | NA |
Num | GO | Overlap | Size | P Value | Adj. P Value |
---|---|---|---|---|---|
1 | POSITIVE REGULATION OF BIOSYNTHETIC PROCESS | 42 | 1805 | 3.215e-08 | 0.0001496 |
2 | SKELETAL SYSTEM DEVELOPMENT | 18 | 455 | 3.434e-07 | 0.0005227 |
3 | EMBRYONIC ORGAN MORPHOGENESIS | 14 | 279 | 4.494e-07 | 0.0005227 |
4 | ORGAN MORPHOGENESIS | 25 | 841 | 3.94e-07 | 0.0005227 |
5 | DEVELOPMENTAL GROWTH | 15 | 333 | 6.814e-07 | 0.0006335 |
6 | NEGATIVE REGULATION OF CELL PROLIFERATION | 21 | 643 | 8.169e-07 | 0.0006335 |
7 | TUBE DEVELOPMENT | 19 | 552 | 1.305e-06 | 0.0008675 |
8 | POSITIVE REGULATION OF MOLECULAR FUNCTION | 38 | 1791 | 1.673e-06 | 0.0009369 |
9 | GROWTH | 16 | 410 | 1.893e-06 | 0.0009369 |
10 | TISSUE DEVELOPMENT | 34 | 1518 | 2.014e-06 | 0.0009369 |
11 | CENTRAL NERVOUS SYSTEM DEVELOPMENT | 24 | 872 | 2.644e-06 | 0.001118 |
12 | EMBRYO DEVELOPMENT | 24 | 894 | 4.048e-06 | 0.00157 |
13 | EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING | 18 | 554 | 5.601e-06 | 0.001861 |
14 | POSITIVE REGULATION OF GENE EXPRESSION | 36 | 1733 | 5.367e-06 | 0.001861 |
15 | REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT | 35 | 1672 | 6.292e-06 | 0.001894 |
16 | DEVELOPMENTAL GROWTH INVOLVED IN MORPHOGENESIS | 8 | 104 | 6.514e-06 | 0.001894 |
17 | CARDIAC MUSCLE TISSUE DEVELOPMENT | 9 | 140 | 7.506e-06 | 0.002003 |
18 | EMBRYONIC ORGAN DEVELOPMENT | 15 | 406 | 7.75e-06 | 0.002003 |
19 | EPITHELIUM DEVELOPMENT | 24 | 945 | 1.027e-05 | 0.002186 |
20 | CELLULAR RESPONSE TO ENDOGENOUS STIMULUS | 25 | 1008 | 9.921e-06 | 0.002186 |
21 | POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER | 25 | 1004 | 9.269e-06 | 0.002186 |
22 | REGULATION OF RAS PROTEIN SIGNAL TRANSDUCTION | 10 | 184 | 1.033e-05 | 0.002186 |
23 | MUSCLE TISSUE DEVELOPMENT | 12 | 275 | 1.263e-05 | 0.002257 |
24 | TISSUE MORPHOGENESIS | 17 | 533 | 1.31e-05 | 0.002257 |
25 | REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS | 25 | 1021 | 1.234e-05 | 0.002257 |
26 | TUBE MORPHOGENESIS | 13 | 323 | 1.297e-05 | 0.002257 |
27 | POSITIVE REGULATION OF CELL DIFFERENTIATION | 22 | 823 | 1.127e-05 | 0.002257 |
28 | POSITIVE REGULATION OF CATALYTIC ACTIVITY | 32 | 1518 | 1.462e-05 | 0.002427 |
29 | EMBRYONIC MORPHOGENESIS | 17 | 539 | 1.512e-05 | 0.002427 |
30 | BONE DEVELOPMENT | 9 | 156 | 1.795e-05 | 0.002784 |
31 | EMBRYONIC SKELETAL SYSTEM DEVELOPMENT | 8 | 122 | 2.108e-05 | 0.003089 |
32 | NEUROGENESIS | 30 | 1402 | 2.124e-05 | 0.003089 |
33 | REGULATION OF CELL DIFFERENTIATION | 31 | 1492 | 2.684e-05 | 0.003785 |
34 | CELL DEVELOPMENT | 30 | 1426 | 2.923e-05 | 0.004001 |
35 | NEGATIVE REGULATION OF RESPONSE TO STIMULUS | 29 | 1360 | 3.164e-05 | 0.004206 |
36 | CARDIOCYTE DIFFERENTIATION | 7 | 96 | 3.532e-05 | 0.004565 |
37 | POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS | 24 | 1036 | 4.544e-05 | 0.005286 |
38 | POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS | 24 | 1036 | 4.544e-05 | 0.005286 |
39 | ORGAN GROWTH | 6 | 68 | 4.427e-05 | 0.005286 |
40 | HEAD DEVELOPMENT | 19 | 709 | 4.478e-05 | 0.005286 |
41 | NEGATIVE REGULATION OF CELL COMMUNICATION | 26 | 1192 | 5.857e-05 | 0.006647 |
42 | CELL JUNCTION ORGANIZATION | 9 | 185 | 6.841e-05 | 0.007398 |
43 | REGULATION OF SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION | 11 | 278 | 7.086e-05 | 0.007398 |
44 | CARDIAC MUSCLE CELL DIFFERENTIATION | 6 | 74 | 7.149e-05 | 0.007398 |
45 | EMBRYONIC CRANIAL SKELETON MORPHOGENESIS | 5 | 46 | 7.155e-05 | 0.007398 |
46 | POSITIVE REGULATION OF DEVELOPMENTAL PROCESS | 25 | 1142 | 7.772e-05 | 0.007862 |
47 | CARTILAGE DEVELOPMENT | 8 | 147 | 7.981e-05 | 0.007902 |
48 | RESPONSE TO ENDOGENOUS STIMULUS | 29 | 1450 | 9.918e-05 | 0.009418 |
49 | CONNECTIVE TISSUE DEVELOPMENT | 9 | 194 | 9.847e-05 | 0.009418 |
50 | TRANSCRIPTION INITIATION FROM RNA POLYMERASE II PROMOTER | 8 | 153 | 0.0001056 | 0.009825 |
Num | GO | Overlap | Size | P Value | Adj. P Value |
---|---|---|---|---|---|
1 | REGULATORY REGION NUCLEIC ACID BINDING | 23 | 818 | 3.054e-06 | 0.0009456 |
2 | TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING | 14 | 328 | 3.044e-06 | 0.0009456 |
3 | TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING | 12 | 226 | 1.696e-06 | 0.0009456 |
4 | TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING | 13 | 315 | 9.932e-06 | 0.001845 |
5 | RNA POLYMERASE II TRANSCRIPTION FACTOR ACTIVITY SEQUENCE SPECIFIC DNA BINDING | 19 | 629 | 8.615e-06 | 0.001845 |
6 | NUCLEIC ACID BINDING TRANSCRIPTION FACTOR ACTIVITY | 27 | 1199 | 2.393e-05 | 0.003706 |
7 | TRANSCRIPTION FACTOR BINDING | 16 | 524 | 4.01e-05 | 0.005321 |
8 | CORE PROMOTER PROXIMAL REGION DNA BINDING | 13 | 371 | 5.472e-05 | 0.006354 |
Num | GO | Overlap | Size | P Value | Adj. P Value |
---|
Num | Pathway | Pathview | Overlap | Size | P Value | Adj. P Value |
---|---|---|---|---|---|---|
1 | MAPK_signaling_pathway_hsa04010 | 12 | 295 | 2.531e-05 | 0.0009672 | |
2 | FoxO_signaling_pathway_hsa04068 | 8 | 132 | 3.72e-05 | 0.0009672 | |
3 | Gap_junction_hsa04540 | 6 | 88 | 0.0001875 | 0.00325 | |
4 | Endocytosis_hsa04144 | 9 | 244 | 0.0005392 | 0.005762 | |
5 | Focal_adhesion_hsa04510 | 8 | 199 | 0.0006256 | 0.005762 | |
6 | Hippo_signaling_pathway_hsa04390 | 7 | 154 | 0.0006649 | 0.005762 | |
7 | Oocyte_meiosis_hsa04114 | 6 | 124 | 0.001168 | 0.008677 | |
8 | Hippo_signaling_pathway_multiple_species_hsa04392 | 3 | 29 | 0.002533 | 0.01546 | |
9 | Wnt_signaling_pathway_hsa04310 | 6 | 146 | 0.002675 | 0.01546 | |
10 | mTOR_signaling_pathway_hsa04150 | 6 | 151 | 0.003161 | 0.01644 | |
11 | Regulation_of_actin_cytoskeleton_hsa04810 | 7 | 208 | 0.003699 | 0.01702 | |
12 | p53_signaling_pathway_hsa04115 | 4 | 68 | 0.003928 | 0.01702 | |
13 | Ferroptosis_hsa04216 | 3 | 40 | 0.006347 | 0.02539 | |
14 | TGF_beta_signaling_pathway_hsa04350 | 4 | 84 | 0.008284 | 0.03077 | |
15 | Phospholipase_D_signaling_pathway_hsa04072 | 5 | 146 | 0.01264 | 0.04383 | |
16 | Cellular_senescence_hsa04218 | 5 | 160 | 0.01811 | 0.05887 | |
17 | cGMP_PKG_signaling_pathway_hsa04022 | 5 | 163 | 0.01946 | 0.05952 | |
18 | Calcium_signaling_pathway_hsa04020 | 5 | 182 | 0.02952 | 0.08528 | |
19 | Apoptosis_hsa04210 | 4 | 138 | 0.04211 | 0.1079 | |
20 | Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 | 4 | 139 | 0.04305 | 0.1079 | |
21 | Cytokine_cytokine_receptor_interaction_hsa04060 | 6 | 270 | 0.04358 | 0.1079 | |
22 | Rap1_signaling_pathway_hsa04015 | 5 | 206 | 0.04624 | 0.1093 | |
23 | Phagosome_hsa04145 | 4 | 152 | 0.05634 | 0.1274 | |
24 | Ras_signaling_pathway_hsa04014 | 5 | 232 | 0.06962 | 0.1508 | |
25 | Sphingolipid_signaling_pathway_hsa04071 | 3 | 118 | 0.1012 | 0.2106 | |
26 | Lysosome_hsa04142 | 3 | 123 | 0.1111 | 0.2221 | |
27 | PI3K_Akt_signaling_pathway_hsa04151 | 6 | 352 | 0.1175 | 0.2263 | |
28 | Apelin_signaling_pathway_hsa04371 | 3 | 137 | 0.1403 | 0.2606 | |
29 | Cell_adhesion_molecules_.CAMs._hsa04514 | 3 | 145 | 0.1581 | 0.2835 | |
30 | ECM_receptor_interaction_hsa04512 | 2 | 82 | 0.1817 | 0.3104 | |
31 | Peroxisome_hsa04146 | 2 | 83 | 0.1851 | 0.3104 | |
32 | ErbB_signaling_pathway_hsa04012 | 2 | 85 | 0.1919 | 0.3118 | |
33 | Tight_junction_hsa04530 | 3 | 170 | 0.2174 | 0.3425 | |
34 | Phosphatidylinositol_signaling_system_hsa04070 | 2 | 99 | 0.2404 | 0.3676 | |
35 | TNF_signaling_pathway_hsa04668 | 2 | 108 | 0.2719 | 0.3927 | |
36 | Cell_cycle_hsa04110 | 2 | 124 | 0.3276 | 0.4605 | |
37 | Autophagy_animal_hsa04140 | 2 | 128 | 0.3414 | 0.4672 | |
38 | Jak_STAT_signaling_pathway_hsa04630 | 2 | 162 | 0.454 | 0.5848 | |
39 | Necroptosis_hsa04217 | 2 | 164 | 0.4603 | 0.5848 | |
40 | cAMP_signaling_pathway_hsa04024 | 2 | 198 | 0.5604 | 0.6777 | |
41 | Neuroactive_ligand_receptor_interaction_hsa04080 | 2 | 278 | 0.7414 | 0.8381 |