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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-140-5p ABCC9 0.84 4.0E-5 -2.76 0 miRanda -0.19 0.04837 NA
2 hsa-miR-140-5p ABLIM1 0.84 4.0E-5 -1.72 0 PITA; miRanda -0.24 0.00036 NA
3 hsa-miR-140-5p ACACA 0.84 4.0E-5 -0.16 0.29248 miRanda -0.17 0 NA
4 hsa-miR-140-5p ADAM10 0.84 4.0E-5 0.67 0.00766 MirTarget; PITA; miRanda -0.12 0.04176 NA
5 hsa-miR-140-5p ADAM9 0.84 4.0E-5 -0.2 0.40665 PITA; miRanda; miRNATAP -0.21 0.00023 NA
6 hsa-miR-140-5p AGAP1 0.84 4.0E-5 -0.4 0.01021 miRanda -0.12 0.00085 NA
7 hsa-miR-140-5p AKAP11 0.84 4.0E-5 -0.8 0 MirTarget; miRanda -0.18 1.0E-5 NA
8 hsa-miR-140-5p AKAP13 0.84 4.0E-5 -1.15 0 miRanda -0.16 1.0E-5 NA
9 hsa-miR-140-5p AKAP6 0.84 4.0E-5 -3.34 0 miRanda -0.44 3.0E-5 NA
10 hsa-miR-139-5p ALDH3B2 -1.53 0 2.64 1.0E-5 miRanda -0.23 0.03345 NA
11 hsa-miR-139-5p ALG11 -1.53 0 0.45 0.03472 miRanda -0.12 0.00188 NA
12 hsa-miR-139-5p AMMECR1 -1.53 0 0.72 0.00063 miRanda -0.17 1.0E-5 NA
13 hsa-miR-139-5p AMPD3 -1.53 0 0.05 0.81987 miRanda -0.12 0.00198 NA
14 hsa-miR-140-5p ANK3 0.84 4.0E-5 -0.29 0.31896 miRanda -0.2 0.00341 NA
15 hsa-miR-140-5p ANKRD12 0.84 4.0E-5 -0.64 0.00012 miRanda -0.13 0.00079 NA
16 hsa-miR-140-5p ANKRD17 0.84 4.0E-5 -0.09 0.56547 miRanda -0.12 0.00072 NA
17 hsa-miR-140-5p ANKRD34A 0.84 4.0E-5 -0.41 0.07282 miRanda -0.15 0.00586 NA
18 hsa-miR-140-5p ANKS1B 0.84 4.0E-5 -3.65 0 miRanda -0.26 0.03078 NA
19 hsa-miR-139-5p ANO1 -1.53 0 1.02 0.02235 miRanda -0.18 0.02021 NA
20 hsa-miR-140-5p ANO6 0.84 4.0E-5 -0.74 3.0E-5 miRanda -0.17 7.0E-5 NA
21 hsa-miR-139-5p APOOL -1.53 0 -0.23 0.29879 miRanda -0.14 0.00023 NA
22 hsa-miR-139-5p ARHGAP32 -1.53 0 0.68 0.00492 miRanda -0.13 0.00371 NA
23 hsa-miR-140-5p ARHGAP32 0.84 4.0E-5 0.68 0.00492 miRanda -0.16 0.00502 NA
24 hsa-miR-140-5p ARHGEF4 0.84 4.0E-5 -1.44 0.0131 miRanda -0.48 0.00046 NA
25 hsa-miR-140-5p ARIH1 0.84 4.0E-5 -0.41 0.00018 MirTarget; miRanda -0.12 1.0E-5 NA
26 hsa-miR-139-5p ARL6IP1 -1.53 0 0.96 0 miRanda -0.1 0.00066 NA
27 hsa-miR-139-5p ARL6IP6 -1.53 0 0.64 4.0E-5 miRanda -0.12 3.0E-5 NA
28 hsa-miR-140-5p ARMC9 0.84 4.0E-5 -0.17 0.43502 miRanda -0.13 0.01514 NA
29 hsa-miR-140-5p ARSK 0.84 4.0E-5 -0.17 0.31336 miRanda -0.1 0.01056 NA
30 hsa-miR-140-5p ASB5 0.84 4.0E-5 -6.18 0 miRanda -0.99 0 NA
31 hsa-miR-139-5p ASB7 -1.53 0 0.19 0.06556 PITA; miRanda -0.1 0 NA
32 hsa-miR-140-5p ASH1L 0.84 4.0E-5 -0.67 0.00016 miRanda -0.26 0 NA
33 hsa-miR-140-5p ASXL2 0.84 4.0E-5 -0.51 0.09339 mirMAP -0.16 0.02429 NA
34 hsa-miR-139-5p ATF7IP -1.53 0 -0 0.99785 miRanda -0.11 0.00026 NA
35 hsa-miR-139-5p ATL2 -1.53 0 -0.08 0.64926 MirTarget; miRanda; miRNATAP -0.12 6.0E-5 NA
36 hsa-miR-140-5p ATP9B 0.84 4.0E-5 -0.61 3.0E-5 miRanda -0.1 0.00301 NA
37 hsa-miR-140-5p BAG4 0.84 4.0E-5 0.14 0.55811 miRanda -0.16 0.00409 NA
38 hsa-miR-139-5p BARX2 -1.53 0 2.53 0.00089 miRanda -0.33 0.01546 NA
39 hsa-miR-139-5p BAZ1A -1.53 0 0.41 0.01012 miRanda -0.16 0 NA
40 hsa-miR-140-5p BAZ2B 0.84 4.0E-5 -0.74 3.0E-5 PITA; miRanda; miRNATAP -0.27 0 NA
41 hsa-miR-140-5p BBS4 0.84 4.0E-5 0.02 0.87409 miRanda -0.13 4.0E-5 NA
42 hsa-miR-140-5p BBS9 0.84 4.0E-5 -0.33 0.02266 miRanda -0.14 3.0E-5 NA
43 hsa-miR-140-5p BCHE 0.84 4.0E-5 -4.37 0 miRanda -0.52 0.00051 NA
44 hsa-miR-140-5p BCL2L2 0.84 4.0E-5 -1.27 0 PITA; miRanda; miRNATAP -0.2 0 NA
45 hsa-miR-140-5p BCL9 0.84 4.0E-5 0.12 0.4783 MirTarget; PITA; miRanda; miRNATAP -0.16 8.0E-5 NA
46 hsa-miR-139-5p BICD1 -1.53 0 0.12 0.64772 miRanda -0.11 0.02217 NA
47 hsa-miR-139-5p BLZF1 -1.53 0 -0.38 0.01298 miRanda -0.1 0.00018 NA
48 hsa-miR-140-5p BMPR1A 0.84 4.0E-5 -0.77 0 miRanda -0.2 0 NA
49 hsa-miR-140-5p BTBD7 0.84 4.0E-5 -0.3 0.03144 PITA -0.17 0 NA
50 hsa-miR-139-5p BUB1 -1.53 0 2.99 0 miRanda -0.25 0 NA
51 hsa-miR-140-5p CACNA1C 0.84 4.0E-5 -2.53 0 PITA; miRNATAP -0.34 0.00027 NA
52 hsa-miR-140-5p CAMK2N1 0.84 4.0E-5 0.6 0.15571 PITA; miRanda -0.35 0.00036 NA
53 hsa-miR-140-5p CASD1 0.84 4.0E-5 -0.65 0.0001 miRNAWalker2 validate -0.11 0.0058 NA
54 hsa-miR-139-5p CASP5 -1.53 0 0.89 0.08562 miRanda -0.2 0.02854 NA
55 hsa-miR-140-5p CAST 0.84 4.0E-5 -0.66 0.00074 miRanda -0.22 0 NA
56 hsa-miR-140-5p CBR4 0.84 4.0E-5 -0.14 0.45863 miRanda -0.11 0.01278 NA
57 hsa-miR-139-5p CCDC120 -1.53 0 0.85 1.0E-5 miRanda -0.12 0.00034 NA
58 hsa-miR-140-5p CCDC146 0.84 4.0E-5 -0.73 0.00616 miRanda -0.19 0.00226 NA
59 hsa-miR-139-5p CCL20 -1.53 0 0.33 0.64296 miRanda -0.3 0.01758 NA
60 hsa-miR-139-5p CCNB1 -1.53 0 2.59 0 miRanda -0.23 0 NA
61 hsa-miR-139-5p CCNF -1.53 0 1.96 0 miRanda -0.12 0.00179 NA
62 hsa-miR-139-5p CCT5 -1.53 0 0.96 0 miRanda -0.11 0.0002 NA
63 hsa-miR-139-5p CD274 -1.53 0 0.06 0.90454 miRanda -0.31 0.00052 NA
64 hsa-miR-139-5p CDCA7 -1.53 0 1.72 0 miRanda -0.21 0.00043 NA
65 hsa-miR-139-5p CDCA8 -1.53 0 3.31 0 miRanda -0.23 1.0E-5 NA
66 hsa-miR-139-5p CDH1 -1.53 0 2.71 0 PITA; miRanda -0.26 0.00181 NA
67 hsa-miR-140-5p CDH26 0.84 4.0E-5 0.92 0.14799 miRanda -0.3 0.04839 NA
68 hsa-miR-139-5p CDK1 -1.53 0 3.39 0 miRanda -0.24 0 NA
69 hsa-miR-140-5p CDK8 0.84 4.0E-5 -0.22 0.28192 miRanda -0.15 0.00247 NA
70 hsa-miR-140-5p CDKL5 0.84 4.0E-5 -0.88 0.05367 miRanda -0.25 0.01826 NA
71 hsa-miR-139-5p CELSR1 -1.53 0 0.45 0.27081 miRanda -0.14 0.04646 NA
72 hsa-miR-139-5p CENPF -1.53 0 3.04 0 miRanda -0.3 0 NA
73 hsa-miR-139-5p CENPW -1.53 0 1.45 0 miRanda -0.14 0.00288 NA
74 hsa-miR-140-5p CEP350 0.84 4.0E-5 -0.04 0.77047 MirTarget; miRanda -0.14 1.0E-5 NA
75 hsa-miR-139-5p CHAC2 -1.53 0 0.98 2.0E-5 miRanda -0.14 0.00096 NA
76 hsa-miR-140-5p CHD6 0.84 4.0E-5 -0.22 0.2394 miRanda -0.14 0.00233 NA
77 hsa-miR-139-5p CHD7 -1.53 0 0.67 0.00044 PITA; miRanda; miRNATAP -0.15 1.0E-5 NA
78 hsa-miR-139-5p CHEK1 -1.53 0 1.6 0 miRanda -0.12 0.0025 NA
79 hsa-miR-140-5p CHIC1 0.84 4.0E-5 -1.03 0 miRanda -0.2 1.0E-5 NA
80 hsa-miR-139-5p CIT -1.53 0 2.11 0 miRanda -0.21 1.0E-5 NA
81 hsa-miR-139-5p CKS2 -1.53 0 2.01 0 miRanda -0.14 0.00061 NA
82 hsa-miR-139-5p CLEC5A -1.53 0 2.07 1.0E-5 miRanda -0.31 0.0002 NA
83 hsa-miR-139-5p CNIH4 -1.53 0 0.54 0 miRanda -0.1 0 NA
84 hsa-miR-139-5p CNKSR1 -1.53 0 2.32 0 miRanda -0.24 4.0E-5 NA
85 hsa-miR-140-5p CNTN1 0.84 4.0E-5 -4.98 0 PITA; miRanda -0.87 1.0E-5 NA
86 hsa-miR-139-5p COL11A1 -1.53 0 4.69 0 miRanda -0.61 6.0E-5 NA
87 hsa-miR-139-5p CPA4 -1.53 0 3.23 2.0E-5 miRanda -0.47 0.00063 NA
88 hsa-miR-139-3p CPT1B -2.64 0 0.58 0.03827 PITA -0.2 1.0E-5 NA
89 hsa-miR-140-5p CRYAB 0.84 4.0E-5 -3.8 0 miRanda -0.34 0.00352 NA
90 hsa-miR-140-5p CRYBG3 0.84 4.0E-5 -1.11 5.0E-5 miRanda -0.13 0.0437 NA
91 hsa-miR-140-5p CSDE1 0.84 4.0E-5 -0.72 0 miRanda -0.18 0 NA
92 hsa-miR-140-5p CTNNA1 0.84 4.0E-5 -0.28 0.01517 miRanda -0.12 3.0E-5 NA
93 hsa-miR-140-5p CTNNA3 0.84 4.0E-5 -1.94 0.00013 miRanda -0.25 0.03981 NA
94 hsa-miR-139-5p CTSC -1.53 0 0.86 0.00468 miRanda -0.13 0.0146 NA
95 hsa-miR-140-5p CTSF 0.84 4.0E-5 -1.38 0 miRanda -0.15 0.02452 NA
96 hsa-miR-139-5p CTTN -1.53 0 0.37 0.06349 miRanda -0.1 0.00327 NA
97 hsa-miR-139-3p CTU1 -2.64 0 1.28 0 MirTarget -0.18 0 NA
98 hsa-miR-140-5p CUEDC1 0.84 4.0E-5 -1.01 2.0E-5 PITA; miRanda -0.2 0.00033 NA
99 hsa-miR-139-5p CXCL10 -1.53 0 1.86 0.00573 miRanda -0.41 0.00061 NA
100 hsa-miR-139-5p CXCL11 -1.53 0 2.31 0.00121 miRanda -0.46 0.00027 NA
101 hsa-miR-140-5p CYP3A7 0.84 4.0E-5 0.59 0.34318 miRanda -0.31 0.036 NA
102 hsa-miR-140-5p CYP4F12 0.84 4.0E-5 -1.43 0.08453 miRanda -0.61 0.00165 NA
103 hsa-miR-140-5p DAAM1 0.84 4.0E-5 -0.94 0.00028 miRanda -0.3 0 NA
104 hsa-miR-140-5p DACT3 0.84 4.0E-5 -3.55 0 miRanda -0.34 0.00204 NA
105 hsa-miR-140-5p DAG1 0.84 4.0E-5 0.32 0.05698 PITA; miRanda; miRNATAP -0.12 0.00204 NA
106 hsa-miR-139-5p DCAF4L1 -1.53 0 1.07 0.00091 miRanda -0.13 0.02199 NA
107 hsa-miR-139-5p DCBLD1 -1.53 0 1.15 0 miRanda -0.18 2.0E-5 NA
108 hsa-miR-140-5p DDHD2 0.84 4.0E-5 -0.57 0.00195 miRanda -0.15 0.00053 NA
109 hsa-miR-139-5p DDX11 -1.53 0 1.5 0 miRanda -0.12 0.00039 NA
110 hsa-miR-139-5p DDX58 -1.53 0 0.2 0.48431 miRanda; mirMAP -0.16 0.00241 NA
111 hsa-miR-139-5p DENND1B -1.53 0 0.36 0.11498 miRanda -0.12 0.00437 NA
112 hsa-miR-139-5p DEPDC1 -1.53 0 3.17 0 miRanda -0.28 0 NA
113 hsa-miR-140-5p DGKB 0.84 4.0E-5 -4.24 0 miRanda -0.51 0.00032 NA
114 hsa-miR-140-5p DIP2C 0.84 4.0E-5 -1.11 0 miRanda -0.19 0.00046 NA
115 hsa-miR-140-5p DIXDC1 0.84 4.0E-5 -3.01 0 miRanda -0.28 0.00062 NA
116 hsa-miR-140-5p DLG2 0.84 4.0E-5 -3.8 0 PITA; miRanda; miRNATAP -0.46 0.00014 NA
117 hsa-miR-140-5p DNAH7 0.84 4.0E-5 -0.49 0.13861 miRanda -0.22 0.0039 NA
118 hsa-miR-140-5p DNAJA4 0.84 4.0E-5 0.2 0.44006 miRanda -0.19 0.00203 NA
119 hsa-miR-140-5p DNAJC18 0.84 4.0E-5 -1.28 0 miRanda -0.12 0.01025 NA
120 hsa-miR-140-5p DNAJC27 0.84 4.0E-5 -0.9 0 miRanda -0.14 8.0E-5 NA
121 hsa-miR-140-5p DNMBP 0.84 4.0E-5 -0.9 0.00012 miRanda -0.17 0.00273 NA
122 hsa-miR-139-5p DOCK5 -1.53 0 -0.05 0.85865 miRanda -0.12 0.0187 NA
123 hsa-miR-140-5p DOK6 0.84 4.0E-5 -3.8 0 mirMAP -0.34 0.00148 NA
124 hsa-miR-139-5p DSC2 -1.53 0 1.52 0.00517 MirTarget; miRanda -0.29 0.00268 NA
125 hsa-miR-139-5p DSG1 -1.53 0 0.69 0.38732 miRanda -0.32 0.02598 NA
126 hsa-miR-140-5p DST 0.84 4.0E-5 -1.12 9.0E-5 mirMAP -0.2 0.00276 NA
127 hsa-miR-140-5p DTNA 0.84 4.0E-5 -4.06 0 PITA; miRanda -0.47 0.00082 NA
128 hsa-miR-139-5p DTX3L -1.53 0 0.74 6.0E-5 miRanda -0.15 0 NA
129 hsa-miR-140-5p DUOX2 0.84 4.0E-5 -0.88 0.1924 miRanda; miRNATAP -0.35 0.02786 NA
130 hsa-miR-139-5p E2F7 -1.53 0 2.72 0 miRanda -0.34 0 NA
131 hsa-miR-139-5p E2F8 -1.53 0 2.88 0 miRanda -0.18 0.00398 NA
132 hsa-miR-140-5p EDA 0.84 4.0E-5 -1.83 3.0E-5 miRanda -0.36 0.00059 NA
133 hsa-miR-140-5p EFCAB2 0.84 4.0E-5 -0.43 0.0619 miRanda -0.13 0.02091 NA
134 hsa-miR-140-5p EFHC2 0.84 4.0E-5 -2.73 0 miRanda -0.33 0.00983 NA
135 hsa-miR-140-5p EGFR 0.84 4.0E-5 -0.23 0.5939 miRanda -0.29 0.00422 NA
136 hsa-miR-140-5p EGLN3 0.84 4.0E-5 -0.29 0.4903 miRanda -0.4 5.0E-5 NA
137 hsa-miR-139-5p EIF2AK2 -1.53 0 0.89 1.0E-5 mirMAP -0.2 0 NA
138 hsa-miR-139-5p EME1 -1.53 0 3.13 0 MirTarget; miRanda -0.2 8.0E-5 NA
139 hsa-miR-140-5p ENPP5 0.84 4.0E-5 -1.2 0.02004 miRanda -0.4 0.00117 NA
140 hsa-miR-140-5p EP300 0.84 4.0E-5 -0.26 0.13065 miRNAWalker2 validate -0.12 0.00415 NA
141 hsa-miR-140-5p EPC2 0.84 4.0E-5 -0.52 9.0E-5 miRanda -0.17 0 NA
142 hsa-miR-140-5p EPHA6 0.84 4.0E-5 -3.76 0 miRanda -0.45 0.00049 NA
143 hsa-miR-140-5p EPN2 0.84 4.0E-5 -0.46 0.00302 miRanda -0.18 0 NA
144 hsa-miR-139-5p ERMP1 -1.53 0 0.59 0.04687 miRanda -0.12 0.02647 NA
145 hsa-miR-139-5p ETV7 -1.53 0 1.67 0 miRanda -0.24 0.00011 NA
146 hsa-miR-139-5p EZH2 -1.53 0 2.33 0 miRanda -0.19 3.0E-5 NA
147 hsa-miR-139-3p F8A1 -2.64 0 1.06 0 MirTarget -0.14 0 NA
148 hsa-miR-140-5p FAM131A 0.84 4.0E-5 -0.84 0.0002 miRanda -0.12 0.031 NA
149 hsa-miR-140-5p FAM172A 0.84 4.0E-5 -1.03 0 miRanda -0.18 0 NA
150 hsa-miR-140-5p FAM179B 0.84 4.0E-5 -0.42 0.00497 miRanda -0.13 0.00015 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 NEGATIVE REGULATION OF CELL CYCLE PROCESS 26 214 5.502e-10 9.833e-07
2 CELL CYCLE 78 1316 6.34e-10 9.833e-07
3 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 97 1784 4.226e-10 9.833e-07
4 CELL CYCLE PROCESS 65 1081 1.151e-08 1.339e-05
5 MITOTIC CELL CYCLE 50 766 5.238e-08 3.482e-05
6 GLAND DEVELOPMENT 33 395 4.222e-08 3.482e-05
7 CELL DEVELOPMENT 77 1426 4.764e-08 3.482e-05
8 NEGATIVE REGULATION OF MITOTIC CELL CYCLE 22 199 6.588e-08 3.832e-05
9 REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 23 220 9.358e-08 4.838e-05
10 NEGATIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 45 684 2.009e-07 9.346e-05
11 NEGATIVE REGULATION OF ORGANELLE ORGANIZATION 31 387 2.769e-07 0.0001171
12 REGULATION OF CELL CYCLE 55 949 5.438e-07 0.0002012
13 REGULATION OF PROTEIN LOCALIZATION 55 950 5.621e-07 0.0002012
14 REGULATION OF CELL CYCLE PROCESS 38 558 7.952e-07 0.0002643
15 NEGATIVE REGULATION OF CELL DIVISION 11 60 9.152e-07 0.0002818
16 TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 45 724 9.69e-07 0.0002818
17 NEGATIVE REGULATION OF CELL CYCLE 32 433 1.058e-06 0.0002896
18 CELL DIVISION 33 460 1.385e-06 0.0003391
19 REGULATION OF CYTOPLASMIC TRANSPORT 34 481 1.335e-06 0.0003391
20 TUBE DEVELOPMENT 37 552 1.619e-06 0.0003587
21 REGULATION OF CELLULAR PROTEIN LOCALIZATION 37 552 1.619e-06 0.0003587
22 REGULATION OF CELLULAR LOCALIZATION 66 1277 2.199e-06 0.0004547
23 TISSUE DEVELOPMENT 75 1518 2.248e-06 0.0004547
24 MITOTIC CELL CYCLE CHECKPOINT 16 139 2.388e-06 0.0004631
25 CELL CYCLE CHECKPOINT 19 194 3.248e-06 0.0006045
26 CHROMOSOME ORGANIZATION 55 1009 3.529e-06 0.000611
27 NEUROGENESIS 70 1402 3.545e-06 0.000611
28 NEGATIVE REGULATION OF MITOTIC NUCLEAR DIVISION 8 34 4.013e-06 0.0006669
29 EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING 36 554 4.523e-06 0.0006844
30 ORGAN MORPHOGENESIS 48 841 4.503e-06 0.0006844
31 NEGATIVE REGULATION OF CELL CYCLE PHASE TRANSITION 16 146 4.56e-06 0.0006844
32 NEGATIVE REGULATION OF NUCLEAR DIVISION 9 46 5.151e-06 0.0007489
33 NEGATIVE REGULATION OF CYTOSKELETON ORGANIZATION 20 221 6.036e-06 0.0008511
34 POSITIVE REGULATION OF GENE EXPRESSION 81 1733 7.037e-06 0.0009631
35 POSITIVE REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 14 121 9.535e-06 0.001268
36 CHROMATIN MODIFICATION 34 539 1.552e-05 0.00197
37 REGULATION OF INTRACELLULAR PROTEIN TRANSPORT 27 381 1.566e-05 0.00197
38 MITOTIC NUCLEAR DIVISION 26 361 1.697e-05 0.002078
39 MICROTUBULE BASED PROCESS 33 522 1.978e-05 0.002276
40 SYMPATHETIC NERVOUS SYSTEM DEVELOPMENT 6 21 2.005e-05 0.002276
41 REGULATION OF CELL CYCLE PHASE TRANSITION 24 321 1.94e-05 0.002276
42 EMBRYO DEVELOPMENT 48 894 2.231e-05 0.002337
43 REGULATION OF CELL CYCLE G1 S PHASE TRANSITION 15 147 2.135e-05 0.002337
44 REGULATION OF CYTOSKELETON ORGANIZATION 32 502 2.243e-05 0.002337
45 REGULATION OF EMBRYONIC DEVELOPMENT 13 114 2.31e-05 0.002337
46 REGULATION OF INTRACELLULAR TRANSPORT 37 621 2.301e-05 0.002337
47 REGULATION OF MICROTUBULE BASED PROCESS 20 243 2.443e-05 0.002419
48 MITOTIC SPINDLE ORGANIZATION 10 69 2.524e-05 0.002447
49 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 52 1004 2.662e-05 0.002528
50 REGULATION OF HYDROLASE ACTIVITY 64 1327 2.809e-05 0.002589
51 MITOTIC DNA INTEGRITY CHECKPOINT 12 100 2.838e-05 0.002589
52 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 50 957 3.055e-05 0.002734
53 REGULATION OF STEM CELL PROLIFERATION 11 88 4.151e-05 0.003644
54 ORGANELLE FISSION 31 496 4.365e-05 0.003761
55 EPITHELIUM DEVELOPMENT 49 945 4.448e-05 0.003763
56 INTRACELLULAR SIGNAL TRANSDUCTION 72 1572 4.655e-05 0.003868
57 REGULATION OF CANONICAL WNT SIGNALING PATHWAY 19 236 5.236e-05 0.004212
58 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 80 1805 5.25e-05 0.004212
59 ESTABLISHMENT OR MAINTENANCE OF CELL POLARITY 14 141 5.402e-05 0.00426
60 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 61 1275 5.514e-05 0.004276
61 CELL PROJECTION ORGANIZATION 47 902 5.673e-05 0.004327
62 REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 18 218 5.906e-05 0.004432
63 TUBE MORPHOGENESIS 23 323 6.124e-05 0.004514
64 SENSORY ORGAN MORPHOGENESIS 19 239 6.209e-05 0.004514
65 MICROTUBULE CYTOSKELETON ORGANIZATION 24 348 7.055e-05 0.00505
66 REGULATION OF PROTEIN IMPORT 16 183 7.651e-05 0.005394
67 DNA INTEGRITY CHECKPOINT 14 146 7.908e-05 0.005492
68 POSITIVE REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 13 129 8.501e-05 0.005817
69 REGULATION OF MITOTIC CELL CYCLE 29 468 8.895e-05 0.005998
70 CHROMATIN ORGANIZATION 37 663 9.056e-05 0.00602
71 REGULATION OF WNT SIGNALING PATHWAY 22 310 9.244e-05 0.006058
72 GLAND MORPHOGENESIS 11 97 0.0001024 0.006615
73 NEURON PROJECTION DEVELOPMENT 32 545 0.0001072 0.006831
74 CHROMOSOME SEGREGATION 20 272 0.0001182 0.007431
75 MUSCLE STRUCTURE DEVELOPMENT 27 432 0.0001342 0.008326
76 TISSUE MORPHOGENESIS 31 533 0.000162 0.009918
NumGOOverlapSizeP ValueAdj. P Value
1 NUCLEIC ACID BINDING TRANSCRIPTION FACTOR ACTIVITY 66 1199 2.428e-07 0.0002256
2 CYTOSKELETAL PROTEIN BINDING 49 819 9.497e-07 0.0003764
3 TUBULIN BINDING 24 273 1.215e-06 0.0003764
4 BETA CATENIN BINDING 12 84 4.622e-06 0.0006414
5 RNA POLYMERASE II TRANSCRIPTION FACTOR ACTIVITY SEQUENCE SPECIFIC DNA BINDING 39 629 5.523e-06 0.0006414
6 DOUBLE STRANDED DNA BINDING 45 764 4.035e-06 0.0006414
7 PROTEIN SERINE THREONINE KINASE ACTIVITY 31 445 5.266e-06 0.0006414
8 ADENYL NUCLEOTIDE BINDING 74 1514 3.902e-06 0.0006414
9 CALCIUM ION BINDING 41 697 1.127e-05 0.001163
10 ENZYME BINDING 80 1737 1.377e-05 0.00128
11 REGULATORY REGION NUCLEIC ACID BINDING 45 818 2.252e-05 0.001902
12 PROTEIN KINASE ACTIVITY 37 640 4.367e-05 0.003381
13 SEQUENCE SPECIFIC DNA BINDING 52 1037 6.188e-05 0.004422
14 KINASE BINDING 35 606 7.146e-05 0.00449
15 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 23 328 7.733e-05 0.00449
16 MACROMOLECULAR COMPLEX BINDING 65 1399 7.407e-05 0.00449
17 PROTEIN BINDING INVOLVED IN CELL ADHESION 5 17 8.746e-05 0.004779
18 RIBONUCLEOTIDE BINDING 80 1860 0.0001416 0.007099
19 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 49 992 0.0001452 0.007099
20 PROTEIN KINASE A BINDING 7 42 0.0001706 0.007923
21 KINASE ACTIVITY 43 842 0.0001825 0.008075
NumGOOverlapSizeP ValueAdj. P Value
1 CYTOSKELETON 102 1967 1.844e-09 1.077e-06
2 MICROTUBULE CYTOSKELETON 65 1068 7.214e-09 2.106e-06
3 CHROMOSOME 55 880 4.719e-08 9.186e-06
4 CYTOSKELETAL PART 75 1436 2.74e-07 4.001e-05
5 SPINDLE 24 289 3.305e-06 0.0003861
6 CELL JUNCTION 60 1151 5.077e-06 0.0004941
7 MICROTUBULE ORGANIZING CENTER 38 623 1.058e-05 0.0008823
8 ANCHORING JUNCTION 32 489 1.334e-05 0.0009736
9 APICAL JUNCTION COMPLEX 14 128 1.824e-05 0.001184
10 NEURON PROJECTION 50 942 2.027e-05 0.001184
11 MITOTIC SPINDLE 9 55 2.365e-05 0.001256
12 CHROMOSOMAL REGION 24 330 3.04e-05 0.001388
13 CENTROSOME 31 487 3.089e-05 0.001388
14 CHROMATIN 28 441 7.749e-05 0.003232
15 CELL CELL JUNCTION 25 383 0.0001205 0.004398
16 DENDRITE 28 451 0.0001135 0.004398
17 MEMBRANE REGION 54 1134 0.0001689 0.005802
18 EXCITATORY SYNAPSE 16 197 0.0001812 0.005879
19 POSTSYNAPSE 24 378 0.0002474 0.007291
20 NUCLEAR CHROMOSOME 30 523 0.0002605 0.007291
21 ORGANELLE SUBCOMPARTMENT 21 311 0.0002622 0.007291
22 CELL PROJECTION 76 1786 0.0002922 0.007757

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 Cell_cycle_hsa04110 14 124 1.267e-05 0.0006408
2 Adherens_junction_hsa04520 10 72 3.686e-05 0.0006408
3 Hippo_signaling_pathway_hsa04390 15 154 3.697e-05 0.0006408
4 Focal_adhesion_hsa04510 14 199 0.001821 0.02367
5 ECM_receptor_interaction_hsa04512 7 82 0.009034 0.081
6 Wnt_signaling_pathway_hsa04310 10 146 0.009347 0.081
7 FoxO_signaling_pathway_hsa04068 9 132 0.01368 0.1016
8 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 9 139 0.01859 0.1208
9 mTOR_signaling_pathway_hsa04150 9 151 0.02979 0.1721
10 Oocyte_meiosis_hsa04114 7 124 0.06549 0.3174
11 HIF_1_signaling_pathway_hsa04066 6 100 0.06714 0.3174
12 Regulation_of_actin_cytoskeleton_hsa04810 10 208 0.07642 0.3303
13 MAPK_signaling_pathway_hsa04010 13 295 0.08257 0.3303
14 Apelin_signaling_pathway_hsa04371 7 137 0.09858 0.3662
15 Gap_junction_hsa04540 5 88 0.1077 0.3734
16 Cell_adhesion_molecules_.CAMs._hsa04514 7 145 0.1228 0.3766
17 p53_signaling_pathway_hsa04115 4 68 0.13 0.3766
18 PI3K_Akt_signaling_pathway_hsa04151 14 352 0.1354 0.3766
19 Rap1_signaling_pathway_hsa04015 9 206 0.1376 0.3766
20 Cytokine_cytokine_receptor_interaction_hsa04060 11 270 0.153 0.3978
21 Cellular_senescence_hsa04218 7 160 0.1753 0.4341
22 Hippo_signaling_pathway_multiple_species_hsa04392 2 29 0.2008 0.4747
23 AMPK_signaling_pathway_hsa04152 5 121 0.2653 0.5998
24 Jak_STAT_signaling_pathway_hsa04630 6 162 0.3188 0.6722
25 Necroptosis_hsa04217 6 164 0.3288 0.6722
26 Ras_signaling_pathway_hsa04014 8 232 0.346 0.6722
27 Tight_junction_hsa04530 6 170 0.3593 0.6722
28 ABC_transporters_hsa02010 2 45 0.3701 0.6722
29 Hedgehog_signaling_pathway_hsa04340 2 47 0.3906 0.6722
30 Endocytosis_hsa04144 8 244 0.398 0.6722
31 Notch_signaling_pathway_hsa04330 2 48 0.4008 0.6722
32 TGF_beta_signaling_pathway_hsa04350 3 84 0.4326 0.6937
33 ErbB_signaling_pathway_hsa04012 3 85 0.4402 0.6937
34 Lysosome_hsa04142 4 123 0.4691 0.7175
35 cAMP_signaling_pathway_hsa04024 6 198 0.5009 0.7442
36 Apoptosis_hsa04210 4 138 0.5594 0.7867
37 Calcium_signaling_pathway_hsa04020 5 182 0.5986 0.7867
38 TNF_signaling_pathway_hsa04668 3 108 0.6005 0.7867
39 Phospholipase_D_signaling_pathway_hsa04072 4 146 0.604 0.7867
40 cGMP_PKG_signaling_pathway_hsa04022 4 163 0.6892 0.8741
41 Autophagy_animal_hsa04140 3 128 0.7129 0.8827
42 Phagosome_hsa04145 2 152 0.9342 1
43 Neuroactive_ligand_receptor_interaction_hsa04080 2 278 0.9972 1

Quest ID: a1d5e3530d89ba1da496f189348ba5d7